{ "name":"msim00001", "children":[ { "name":"09100 Metabolism", "children":[ { "name":"09101 Carbohydrate metabolism", "children":[ { "name":"00010 Glycolysis \/ Gluconeogenesis [PATH:msim00010]", "children":[ { "name":"MSIM_16360 sugar kinase\tK25026 glk; glucokinase [EC:2.7.1.2]" }, { "name":"MSIM_34670 pgi; glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]" }, { "name":"MSIM_08380 pfkA; ATP-dependent 6-phosphofructokinase\tK21071 pfk; ATP-dependent phosphofructokinase \/ diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90]" }, { "name":"MSIM_37350 glpX; fructose-1,6-bisphosphatase class 2\tK02446 glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]" }, { "name":"MSIM_12270 gpm2; phosphoglycerate mutase\tK28849 gpm2; fructose-bisphosphatase [EC:3.1.3.11]" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_18880 fba; fructose-bisphosphate aldolase\tK01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]" }, { "name":"MSIM_02390 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]" }, { "name":"MSIM_02410 gap; glyceraldehyde-3-phosphate dehydrogenase\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]" }, { "name":"MSIM_02400 pgk; phosphoglycerate kinase\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]" }, { "name":"MSIM_17650 gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]" }, { "name":"MSIM_36760 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"MSIM_00810 pykA; pyruvate kinase\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_06140 hypothetical protein\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_37650 ppdK; pyruvate, phosphate dikinase\tK01006 ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]" }, { "name":"MSIM_07830 pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45200 aceE; pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45660 hypothetical protein\tK00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_41720 korA; 2-oxoglutarate oxidoreductase subunit KorA\tK00174 korA; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_41730 korB; 2-oxoglutarate oxidoreductase subunit KorB\tK00175 korB; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_30180 adhB; alcohol dehydrogenase B\tK00121 frmA; S-(hydroxymethyl)glutathione dehydrogenase \/ alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]" }, { "name":"MSIM_09660 alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_51380 adhA; alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_08880 adhC; NADP-dependent alcohol dehydrogenase C\tK13979 yahK; alcohol dehydrogenase (NADP+) [EC:1.1.1.2]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_17940 putative aldehyde dehydrogenase\tK00138 aldB; aldehyde dehydrogenase [EC:1.2.1.-]" }, { "name":"MSIM_28060 acsA; acetyl-coenzyme A synthetase\tK01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]" }, { "name":"MSIM_19140 aldose 1-epimerase\tK01785 galM; aldose 1-epimerase [EC:5.1.3.3]" }, { "name":"MSIM_09910 pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific\tK01835 pgm; phosphoglucomutase [EC:5.4.2.2]" }, { "name":"MSIM_04990 ppgK; polyphosphate glucokinase\tK00886 ppgK; polyphosphate glucokinase [EC:2.7.1.63]" }, { "name":"MSIM_20740 pckG; phosphoenolpyruvate carboxykinase [GTP]\tK01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]" } ] }, { "name":"00020 Citrate cycle (TCA cycle) [PATH:msim00020]", "children":[ { "name":"MSIM_33050 citA; putative citrate synthase 2\tK01647 CS; citrate synthase [EC:2.3.3.1]" }, { "name":"MSIM_33080 gltA2; citrate synthase 1\tK01647 CS; citrate synthase [EC:2.3.3.1]" }, { "name":"MSIM_37720 prpC; 2-methylcitrate synthase\tK01659 prpC; 2-methylcitrate synthase [EC:2.3.3.5]" }, { "name":"MSIM_02070 acn; aconitate hydratase\tK27802 acnA; aconitate hydratase A \/ 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]" }, { "name":"MSIM_14170 icd2; isocitrate dehydrogenase, NADP-dependent\tK00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]" }, { "name":"MSIM_38900 kgd; multifunctional 2-oxoglutarate metabolism enzyme\tK01616 kgd; multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_41720 korA; 2-oxoglutarate oxidoreductase subunit KorA\tK00174 korA; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_41730 korB; 2-oxoglutarate oxidoreductase subunit KorB\tK00175 korB; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_08940 succinyl-CoA synthetase subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_34740 succinate--CoA ligase [ADP-forming] subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_08950 sucC_1; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_34730 sucC_2; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_14020 sdhA; succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_20190 succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_14030 sdhB; succinate dehydrogenase iron-sulphur protein subunit\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_20200 fumarate reductase\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_14000 sdhC; succinate dehydrogenase 2 membrane subunit SdhC\tK00241 sdhC; succinate dehydrogenase cytochrome b subunit" }, { "name":"MSIM_14010 sdhD; succinate dehydrogenase\tK00242 sdhD; succinate dehydrogenase membrane anchor subunit" }, { "name":"MSIM_37340 fumC; fumarate hydratase\tK01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]" }, { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" }, { "name":"MSIM_06450 mqo; putative malate:quinone oxidoreductase\tK00116 mqo; malate dehydrogenase (quinone) [EC:1.1.5.4]" }, { "name":"MSIM_07950 pca; pyruvate carboxylase\tK01958 PC; pyruvate carboxylase [EC:6.4.1.1]" }, { "name":"MSIM_20740 pckG; phosphoenolpyruvate carboxykinase [GTP]\tK01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]" }, { "name":"MSIM_07830 pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45200 aceE; pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45660 hypothetical protein\tK00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]" } ] }, { "name":"00030 Pentose phosphate pathway [PATH:msim00030]", "children":[ { "name":"MSIM_34670 pgi; glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]" }, { "name":"MSIM_02320 zwf2; glucose-6-phosphate 1-dehydrogenase 2\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_37580 zwf1; glucose-6-phosphate 1-dehydrogenase 1\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_49840 zwf; glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_02340 pgl; 6-phosphogluconolactonase\tK01057 PGLS; 6-phosphogluconolactonase [EC:3.1.1.31]" }, { "name":"MSIM_37590 gnd2; 6-phosphogluconate dehydrogenase (decarboxylating)\tK00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]" }, { "name":"MSIM_51680 gnd; 6-phosphogluconate dehydrogenase, decarboxylating\tK00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]" }, { "name":"MSIM_02620 rpe; ribulose-phosphate 3-epimerase\tK01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]" }, { "name":"MSIM_02300 tkt; transketolase\tK00615 E2.2.1.1; transketolase [EC:2.2.1.1]" }, { "name":"MSIM_02310 tal_1; transaldolase\tK00616 TALDO1; transaldolase [EC:2.2.1.2]" }, { "name":"MSIM_33410 tal_2; transaldolase\tK00616 TALDO1; transaldolase [EC:2.2.1.2]" }, { "name":"MSIM_41630 rpiB; ribose-5-phosphate isomerase B\tK01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]" }, { "name":"MSIM_51360 xfp; putative phosphoketolase\tK01621 xfp; xylulose-5-phosphate\/fructose-6-phosphate phosphoketolase [EC:4.1.2.9 4.1.2.22]" }, { "name":"MSIM_17750 deoC; deoxyribose-phosphate aldolase\tK01619 deoC; deoxyribose-phosphate aldolase [EC:4.1.2.4]" }, { "name":"MSIM_26750 rbsK_1; ribokinase\tK00852 rbsK; ribokinase [EC:2.7.1.15]" }, { "name":"MSIM_41990 rbsK_2; ribokinase\tK00852 rbsK; ribokinase [EC:2.7.1.15]" }, { "name":"MSIM_09910 pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific\tK01835 pgm; phosphoglucomutase [EC:5.4.2.2]" }, { "name":"MSIM_36670 prs; ribose-phosphate pyrophosphokinase\tK00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]" }, { "name":"MSIM_34020 hypothetical protein\tK01053 gnl; gluconolactonase [EC:3.1.1.17]" }, { "name":"MSIM_47880 aroK_2; gluconokinase\tK00851 idnK; gluconokinase [EC:2.7.1.12]" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_18880 fba; fructose-bisphosphate aldolase\tK01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]" }, { "name":"MSIM_37350 glpX; fructose-1,6-bisphosphatase class 2\tK02446 glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]" }, { "name":"MSIM_12270 gpm2; phosphoglycerate mutase\tK28849 gpm2; fructose-bisphosphatase [EC:3.1.3.11]" }, { "name":"MSIM_08380 pfkA; ATP-dependent 6-phosphofructokinase\tK21071 pfk; ATP-dependent phosphofructokinase \/ diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90]" } ] }, { "name":"00040 Pentose and glucuronate interconversions [PATH:msim00040]", "children":[ { "name":"MSIM_01680 ugd_1; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_11540 ugd_2; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_19380 udgA; UDP-glucose 6-dehydrogenase UdgA\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_36260 ugd_3; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_35000 galU; UDP-glucose pyrophosphorylase\tK00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]" }, { "name":"MSIM_02620 rpe; ribulose-phosphate 3-epimerase\tK01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]" }, { "name":"MSIM_15600 xylB; D-xylulose kinase\tK00854 xylB; xylulokinase [EC:2.7.1.17]" }, { "name":"MSIM_15640 carbohydrate kinase\tK00854 xylB; xylulokinase [EC:2.7.1.17]" }, { "name":"MSIM_03520 putative class II aldolase\tK01628 fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]" }, { "name":"MSIM_15620 fucA; fuculose phosphate aldolase\tK01628 fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]" } ] }, { "name":"00051 Fructose and mannose metabolism [PATH:msim00051]", "children":[ { "name":"MSIM_34510 fructokinase\tK00847 E2.7.1.4; fructokinase [EC:2.7.1.4]" }, { "name":"MSIM_13010 manA; mannose-6-phosphate isomerase, class I\tK01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]" }, { "name":"MSIM_13030 manB; phosphomannomutase\/phosphoglucomutase\tK01840 manB; phosphomannomutase [EC:5.4.2.8]" }, { "name":"MSIM_13860 pmmB; phosphomannomutase\tK01840 manB; phosphomannomutase [EC:5.4.2.8]" }, { "name":"MSIM_13120 rmlA2; GDP-mannose pyrophosphorylase\tK00966 GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]" }, { "name":"MSIM_01660 gmdA; GDP-mannose 4,6-dehydratase\tK01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47]" }, { "name":"MSIM_01650 epiA; GDP-L-fucose synthase\tK02377 TSTA3; GDP-L-fucose synthase [EC:1.1.1.271]" }, { "name":"MSIM_03520 putative class II aldolase\tK01628 fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]" }, { "name":"MSIM_15620 fucA; fuculose phosphate aldolase\tK01628 fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]" }, { "name":"MSIM_08380 pfkA; ATP-dependent 6-phosphofructokinase\tK21071 pfk; ATP-dependent phosphofructokinase \/ diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90]" }, { "name":"MSIM_37350 glpX; fructose-1,6-bisphosphatase class 2\tK02446 glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]" }, { "name":"MSIM_12270 gpm2; phosphoglycerate mutase\tK28849 gpm2; fructose-bisphosphatase [EC:3.1.3.11]" }, { "name":"MSIM_34520 mannitol 2-dehydrogenase\tK00045 mtlK; mannitol 2-dehydrogenase [EC:1.1.1.67]" }, { "name":"MSIM_34540 mtlD; mannitol dehydrogenase\tK00045 mtlK; mannitol 2-dehydrogenase [EC:1.1.1.67]" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_18880 fba; fructose-bisphosphate aldolase\tK01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]" }, { "name":"MSIM_02390 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]" }, { "name":"MSIM_41630 rpiB; ribose-5-phosphate isomerase B\tK01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]" }, { "name":"MSIM_43830 phosphatase\tK19270 hxpA; mannitol-1-\/sugar-\/sorbitol-6-phosphatase [EC:3.1.3.22 3.1.3.23 3.1.3.50]" } ] }, { "name":"00052 Galactose metabolism [PATH:msim00052]", "children":[ { "name":"MSIM_19140 aldose 1-epimerase\tK01785 galM; aldose 1-epimerase [EC:5.1.3.3]" }, { "name":"MSIM_16670 galK; galactokinase\tK00849 galK; galactokinase [EC:2.7.1.6]" }, { "name":"MSIM_16680 galT; galactose-1-phosphate uridylyltransferase\tK00965 galT; UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]" }, { "name":"MSIM_07300 hypothetical protein\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_17510 hypothetical protein\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_28310 galE1; UDP-glucose 4-epimerase\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_36290 NAD-dependent dehydratase\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_35000 galU; UDP-glucose pyrophosphorylase\tK00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]" }, { "name":"MSIM_09910 pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific\tK01835 pgm; phosphoglucomutase [EC:5.4.2.2]" }, { "name":"MSIM_16360 sugar kinase\tK25026 glk; glucokinase [EC:2.7.1.2]" }, { "name":"MSIM_25900 glf; UDP-galactopyranose mutase\tK01854 glf; UDP-galactopyranose mutase [EC:5.4.99.9]" }, { "name":"MSIM_08380 pfkA; ATP-dependent 6-phosphofructokinase\tK21071 pfk; ATP-dependent phosphofructokinase \/ diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90]" }, { "name":"MSIM_41560 aglA; alpha-glucosidase AglA\tK01187 malZ; alpha-glucosidase [EC:3.2.1.20]" } ] }, { "name":"00053 Ascorbate and aldarate metabolism [PATH:msim00053]", "children":[ { "name":"MSIM_01680 ugd_1; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_11540 ugd_2; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_19380 udgA; UDP-glucose 6-dehydrogenase UdgA\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_36260 ugd_3; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_34020 hypothetical protein\tK01053 gnl; gluconolactonase [EC:3.1.1.17]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" } ] }, { "name":"00500 Starch and sucrose metabolism [PATH:msim00500]", "children":[ { "name":"MSIM_41560 aglA; alpha-glucosidase AglA\tK01187 malZ; alpha-glucosidase [EC:3.2.1.20]" }, { "name":"MSIM_35000 galU; UDP-glucose pyrophosphorylase\tK00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]" }, { "name":"MSIM_21050 bglS; beta-glucosidase\tK05349 bglX; beta-glucosidase [EC:3.2.1.21]" }, { "name":"MSIM_23800 celA1; glucanase\tK01179 E3.2.1.4; endoglucanase [EC:3.2.1.4]" }, { "name":"MSIM_38630 glgC; glucose-1-phosphate adenylyltransferase\tK00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]" }, { "name":"MSIM_08570 transferase\tK16150 K16150; glycogen synthase [EC:2.4.1.11]" }, { "name":"MSIM_39910 glgB; 1,4-alpha-glucan branching enzyme GlgB\tK00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]" }, { "name":"MSIM_08560 putative 1,4-alpha-glucan branching enzyme\tK16149 K16149; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]" }, { "name":"MSIM_09670 alpha-1,4 glucan phosphorylase\tK00688 PYG; glycogen phosphorylase [EC:2.4.1.1]" }, { "name":"MSIM_39930 glgP; glycogen phosphorylase\tK00688 PYG; glycogen phosphorylase [EC:2.4.1.1]" }, { "name":"MSIM_22150 treS; trehalose synthase\/amylase TreS\tK05343 treS; maltose alpha-D-glucosyltransferase \/ alpha-amylase [EC:5.4.99.16 3.2.1.1]" }, { "name":"MSIM_51160 alpha-amylase\tK01208 cd; cyclomaltodextrinase \/ maltogenic alpha-amylase \/ neopullulanase [EC:3.2.1.54 3.2.1.133 3.2.1.135]" }, { "name":"MSIM_46930 malQ_1; 4-alpha-glucanotransferase\tK00705 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]" }, { "name":"MSIM_52220 malQ_2; 4-alpha-glucanotransferase\tK00705 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]" }, { "name":"MSIM_22140 mak; maltokinase\tK16146 pep2; maltokinase [EC:2.7.1.175]" }, { "name":"MSIM_39920 glgE; alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase\tK16147 glgE; starch synthase (maltosyl-transferring) [EC:2.4.99.16]" }, { "name":"MSIM_38620 glgA; capsular glucan synthase\tK16148 glgM; alpha-maltose-1-phosphate synthase [EC:2.4.1.342]" }, { "name":"MSIM_01220 glgX_1; glycogen operon protein GlgX homolog\tK01214 ISA; isoamylase [EC:3.2.1.68]" }, { "name":"MSIM_11660 glgX_2; glycogen operon protein GlgX homolog\tK01214 ISA; isoamylase [EC:3.2.1.68]" }, { "name":"MSIM_01230 treY; putative maltooligosyl trehalose synthase\tK06044 treY; (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase [EC:5.4.99.15]" }, { "name":"MSIM_01240 treZ; malto-oligosyltrehalose trehalohydrolase\tK01236 treZ; maltooligosyltrehalose trehalohydrolase [EC:3.2.1.141]" }, { "name":"MSIM_29830 otsA; trehalose-phosphate synthase\tK00697 otsA; trehalose 6-phosphate synthase [EC:2.4.1.15 2.4.1.347]" }, { "name":"MSIM_14450 otsB; trehalose-phosphate phosphatase\tK01087 otsB; trehalose 6-phosphate phosphatase [EC:3.1.3.12]" }, { "name":"MSIM_42340 trehalase\tK22934 E3.2.1.28; alpha,alpha-trehalase [EC:3.2.1.28]" }, { "name":"MSIM_09910 pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific\tK01835 pgm; phosphoglucomutase [EC:5.4.2.2]" }, { "name":"MSIM_16360 sugar kinase\tK25026 glk; glucokinase [EC:2.7.1.2]" }, { "name":"MSIM_34670 pgi; glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]" }, { "name":"MSIM_34510 fructokinase\tK00847 E2.7.1.4; fructokinase [EC:2.7.1.4]" } ] }, { "name":"00620 Pyruvate metabolism [PATH:msim00620]", "children":[ { "name":"MSIM_28060 acsA; acetyl-coenzyme A synthetase\tK01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]" }, { "name":"MSIM_41720 korA; 2-oxoglutarate oxidoreductase subunit KorA\tK00174 korA; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_41730 korB; 2-oxoglutarate oxidoreductase subunit KorB\tK00175 korB; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_07830 pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45200 aceE; pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45660 hypothetical protein\tK00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_29440 mhpF; acetaldehyde dehydrogenase 2\tK04073 mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10]" }, { "name":"MSIM_09660 alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_51380 adhA; alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_30180 adhB; alcohol dehydrogenase B\tK00121 frmA; S-(hydroxymethyl)glutathione dehydrogenase \/ alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]" }, { "name":"MSIM_08880 adhC; NADP-dependent alcohol dehydrogenase C\tK13979 yahK; alcohol dehydrogenase (NADP+) [EC:1.1.1.2]" }, { "name":"MSIM_18610 ackA; acetate kinase\tK00925 ackA; acetate kinase [EC:2.7.2.1]" }, { "name":"MSIM_18620 pta; phosphate acetyltransferase\tK13788 pta; phosphate acetyltransferase [EC:2.3.1.8]" }, { "name":"MSIM_08970 eutD; phosphate acetyltransferase\tK04020 eutD; phosphotransacetylase" }, { "name":"MSIM_00810 pykA; pyruvate kinase\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_06140 hypothetical protein\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_12340 biotinylated protein TB7.3\tK02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein" }, { "name":"MSIM_13640 acetyl-\/propionyl-CoA carboxylase subunit alpha\tK11263 bccA; acetyl-CoA\/propionyl-CoA\/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]" }, { "name":"MSIM_45140 accD6; putative propionyl-CoA carboxylase beta chain 6\tK18472 accD6; acetyl-CoA\/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]" }, { "name":"MSIM_07610 acyP; acylphosphatase\tK01512 acyP; acylphosphatase [EC:3.6.1.7]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_17940 putative aldehyde dehydrogenase\tK00138 aldB; aldehyde dehydrogenase [EC:1.2.1.-]" }, { "name":"MSIM_11570 poxB; thiamine pyrophosphate-requiring protein\tK00156 poxB; pyruvate dehydrogenase (quinone) [EC:1.2.5.1]" }, { "name":"MSIM_06990 lactate 2-monooxygenase\tK00467 E1.13.12.4; lactate 2-monooxygenase [EC:1.13.12.4]" }, { "name":"MSIM_46600 lactate 2-monooxygenase\tK00467 E1.13.12.4; lactate 2-monooxygenase [EC:1.13.12.4]" }, { "name":"MSIM_33950 hypothetical protein\tK01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5]" }, { "name":"MSIM_44800 glyoxalase\tK01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5]" }, { "name":"MSIM_03820 hypothetical protein\tK01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6]" }, { "name":"MSIM_38860 putative malate dehydrogenase\tK00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]" }, { "name":"MSIM_43140 mez; NAD-dependent malic enzyme\tK00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]" }, { "name":"MSIM_07950 pca; pyruvate carboxylase\tK01958 PC; pyruvate carboxylase [EC:6.4.1.1]" }, { "name":"MSIM_07450 hypothetical protein\tK29029 FAHD2; oxaloacetate tautomerase [EC:5.3.2.2]" }, { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" }, { "name":"MSIM_06450 mqo; putative malate:quinone oxidoreductase\tK00116 mqo; malate dehydrogenase (quinone) [EC:1.1.5.4]" }, { "name":"MSIM_37340 fumC; fumarate hydratase\tK01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]" }, { "name":"MSIM_02370 ppc; phosphoenolpyruvate carboxylase\tK01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]" }, { "name":"MSIM_20740 pckG; phosphoenolpyruvate carboxykinase [GTP]\tK01596 E4.1.1.32; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]" }, { "name":"MSIM_37650 ppdK; pyruvate, phosphate dikinase\tK01006 ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]" }, { "name":"MSIM_51720 glcB; malate synthase G\tK01638 aceB; malate synthase [EC:2.3.3.9]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_27370 leuA; 2-isopropylmalate synthase\tK01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]" }, { "name":"MSIM_51180 lldD; putative L-lactate dehydrogenase\tK29125" } ] }, { "name":"00630 Glyoxylate and dicarboxylate metabolism [PATH:msim00630]", "children":[ { "name":"MSIM_17840 aceA_1; isocitrate lyase\tK01637 ICL; isocitrate\/methylisocitrate lyase [EC:4.1.3.1 4.1.3.30]" }, { "name":"MSIM_50440 aceA_2; isocitrate lyase 2\tK01637 ICL; isocitrate\/methylisocitrate lyase [EC:4.1.3.1 4.1.3.30]" }, { "name":"MSIM_51720 glcB; malate synthase G\tK01638 aceB; malate synthase [EC:2.3.3.9]" }, { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" }, { "name":"MSIM_33050 citA; putative citrate synthase 2\tK01647 CS; citrate synthase [EC:2.3.3.1]" }, { "name":"MSIM_33080 gltA2; citrate synthase 1\tK01647 CS; citrate synthase [EC:2.3.3.1]" }, { "name":"MSIM_37720 prpC; 2-methylcitrate synthase\tK01659 prpC; 2-methylcitrate synthase [EC:2.3.3.5]" }, { "name":"MSIM_02070 acn; aconitate hydratase\tK27802 acnA; aconitate hydratase A \/ 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]" }, { "name":"MSIM_28060 acsA; acetyl-coenzyme A synthetase\tK01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39880 methylmalonyl-CoA epimerase\tK05606 MCEE; methylmalonyl-CoA\/ethylmalonyl-CoA epimerase [EC:5.1.99.1]" }, { "name":"MSIM_13640 acetyl-\/propionyl-CoA carboxylase subunit alpha\tK11263 bccA; acetyl-CoA\/propionyl-CoA\/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]" }, { "name":"MSIM_13590 accD5; putative propionyl-CoA carboxylase beta chain 5\tK27094 accD5; propionyl-CoA\/long-chain acyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.3 6.4.1.- 2.1.3.15]" }, { "name":"MSIM_13600 hypothetical protein\tK27095 accE5; acyl-CoA carboxylase epsilon subunit" }, { "name":"MSIM_45140 accD6; putative propionyl-CoA carboxylase beta chain 6\tK18472 accD6; acetyl-CoA\/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]" }, { "name":"MSIM_01870 mutB; putative methylmalonyl-CoA mutase large subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_01880 mutA; putative methylmalonyl-CoA mutase small subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_31330 methylmalonyl-CoA mutase\tK01849 E5.4.99.2B; methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_31320 methylmalonyl-CoA mutase\tK01848 E5.4.99.2A; methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_31170 FAD-binding protein\tK00104 glcD; glycolate dehydrogenase FAD-linked subunit [EC:1.1.99.14]" }, { "name":"MSIM_39000 oxidoreductase\tK00104 glcD; glycolate dehydrogenase FAD-linked subunit [EC:1.1.99.14]" }, { "name":"MSIM_44730 dehydrogenase\tK00104 glcD; glycolate dehydrogenase FAD-linked subunit [EC:1.1.99.14]" }, { "name":"MSIM_46610 FAD-binding protein\tK00104 glcD; glycolate dehydrogenase FAD-linked subunit [EC:1.1.99.14]" }, { "name":"MSIM_04380 srpA; catalase-related peroxidase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_23170 catalase-related peroxidase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_27440 katA; catalase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_45380 hypothetical protein\tK01091 gph; phosphoglycolate phosphatase [EC:3.1.3.18]" }, { "name":"MSIM_28420 glnT; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45490 glnA2; putative glutamine synthetase 2\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45600 glnA1; glutamine synthetase 1\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51050 glnA3; glutamine synthetase GlnA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51550 type III glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_53180 glnN; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_37280 glyA1; serine hydroxymethyltransferase 1\tK00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]" }, { "name":"MSIM_51750 gcvP; putative glycine dehydrogenase (decarboxylating)\tK00281 GLDC; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]" }, { "name":"MSIM_45730 gcvT; aminomethyltransferase\tK00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_46520 gcvH_1; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" }, { "name":"MSIM_51810 gcvH_2; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" }, { "name":"MSIM_06110 gcl; glyoxylate carboligase\tK01608 gcl; tartronate-semialdehyde synthase [EC:4.1.1.47]" }, { "name":"MSIM_06090 hydroxypyruvate isomerase\tK01816 hyi; hydroxypyruvate isomerase [EC:5.3.1.22]" }, { "name":"MSIM_06100 2-hydroxy-3-oxopropionate reductase\tK00042 garR; 2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60]" }, { "name":"MSIM_06080 glxK; glycerate kinase\tK00865 glxK; glycerate 2-kinase [EC:2.7.1.165]" }, { "name":"MSIM_45790 hypothetical protein\tK00865 glxK; glycerate 2-kinase [EC:2.7.1.165]" }, { "name":"MSIM_38900 kgd; multifunctional 2-oxoglutarate metabolism enzyme\tK01616 kgd; multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]" }, { "name":"MSIM_44390 cupin\tK01569 oxdD; oxalate decarboxylase [EC:4.1.1.2]" }, { "name":"MSIM_06190 formate dehydrogenase\tK00122 FDH; formate dehydrogenase [EC:1.17.1.9]" }, { "name":"MSIM_23350 formate dehydrogenase subunit alpha\tK00123 fdoG; formate dehydrogenase major subunit [EC:1.17.1.9]" }, { "name":"MSIM_23340 4Fe-4S ferredoxin\tK00124 fdoH; formate dehydrogenase iron-sulfur subunit" }, { "name":"MSIM_09890 formamidase\tK01455 fmdA; formamidase [EC:3.5.1.49]" }, { "name":"MSIM_06250 oxalyl-CoA decarboxylase\tK01577 oxc; oxalyl-CoA decarboxylase [EC:4.1.1.8]" }, { "name":"MSIM_22210 oxcA; oxalyl-CoA decarboxylase\tK01577 oxc; oxalyl-CoA decarboxylase [EC:4.1.1.8]" }, { "name":"MSIM_06220 frc_1; formyl-CoA:oxalate CoA-transferase\tK07749 frc; formyl-CoA transferase [EC:2.8.3.16]" }, { "name":"MSIM_06240 frc_2; formyl-CoA:oxalate CoA-transferase\tK07749 frc; formyl-CoA transferase [EC:2.8.3.16]" } ] }, { "name":"00640 Propanoate metabolism [PATH:msim00640]", "children":[ { "name":"MSIM_28060 acsA; acetyl-coenzyme A synthetase\tK01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]" }, { "name":"MSIM_18610 ackA; acetate kinase\tK00925 ackA; acetate kinase [EC:2.7.2.1]" }, { "name":"MSIM_18620 pta; phosphate acetyltransferase\tK13788 pta; phosphate acetyltransferase [EC:2.3.1.8]" }, { "name":"MSIM_34130 bkdA; 2-oxoisovalerate dehydrogenase E1\tK11381 bkdA; 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_43200 acyl-CoA oxidase\tK00232 ACOX1_3; acyl-CoA oxidase [EC:1.3.3.6]" }, { "name":"MSIM_10840 alcohol dehydrogenase\tK19745 acuI; acrylyl-CoA reductase (NADPH) [EC:1.3.1.-]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_12340 biotinylated protein TB7.3\tK02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein" }, { "name":"MSIM_13640 acetyl-\/propionyl-CoA carboxylase subunit alpha\tK11263 bccA; acetyl-CoA\/propionyl-CoA\/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]" }, { "name":"MSIM_45140 accD6; putative propionyl-CoA carboxylase beta chain 6\tK18472 accD6; acetyl-CoA\/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]" }, { "name":"MSIM_03910 gabT; 4-aminobutyrate aminotransferase\tK07250 gabT; 4-aminobutyrate aminotransferase \/ (S)-3-amino-2-methylpropionate transaminase \/ 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]" }, { "name":"MSIM_13590 accD5; putative propionyl-CoA carboxylase beta chain 5\tK27094 accD5; propionyl-CoA\/long-chain acyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.3 6.4.1.- 2.1.3.15]" }, { "name":"MSIM_13600 hypothetical protein\tK27095 accE5; acyl-CoA carboxylase epsilon subunit" }, { "name":"MSIM_39880 methylmalonyl-CoA epimerase\tK05606 MCEE; methylmalonyl-CoA\/ethylmalonyl-CoA epimerase [EC:5.1.99.1]" }, { "name":"MSIM_01870 mutB; putative methylmalonyl-CoA mutase large subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_01880 mutA; putative methylmalonyl-CoA mutase small subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_31330 methylmalonyl-CoA mutase\tK01849 E5.4.99.2B; methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_31320 methylmalonyl-CoA mutase\tK01848 E5.4.99.2A; methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_08950 sucC_1; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_34730 sucC_2; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_08940 succinyl-CoA synthetase subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_34740 succinate--CoA ligase [ADP-forming] subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_15430 mmsA; methylmalonate-semialdehyde dehydrogenase (acylating)\tK00140 mmsA; malonate-semialdehyde dehydrogenase (acetylating) \/ methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]" }, { "name":"MSIM_37720 prpC; 2-methylcitrate synthase\tK01659 prpC; 2-methylcitrate synthase [EC:2.3.3.5]" }, { "name":"MSIM_22680 2-methylcitrate dehydratase\tK01720 prpD; 2-methylcitrate dehydratase [EC:4.2.1.79]" }, { "name":"MSIM_37700 prpD; 2-methylcitrate dehydratase\tK01720 prpD; 2-methylcitrate dehydratase [EC:4.2.1.79]" }, { "name":"MSIM_02070 acn; aconitate hydratase\tK27802 acnA; aconitate hydratase A \/ 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]" }, { "name":"MSIM_37710 prpB; 2-methylisocitrate lyase\tK03417 prpB; methylisocitrate lyase [EC:4.1.3.30]" }, { "name":"MSIM_17840 aceA_1; isocitrate lyase\tK01637 ICL; isocitrate\/methylisocitrate lyase [EC:4.1.3.1 4.1.3.30]" }, { "name":"MSIM_50440 aceA_2; isocitrate lyase 2\tK01637 ICL; isocitrate\/methylisocitrate lyase [EC:4.1.3.1 4.1.3.30]" } ] }, { "name":"00650 Butanoate metabolism [PATH:msim00650]", "children":[ { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_12460 putative dehydrogenase (3-hydroxybutyryl-CoA dehydrogenase FadB?)\tK00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]" }, { "name":"MSIM_17830 fadB2; 3-hydroxybutyryl-CoA dehydrogenase\tK00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_29440 mhpF; acetaldehyde dehydrogenase 2\tK04073 mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10]" }, { "name":"MSIM_14020 sdhA; succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_20190 succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_14030 sdhB; succinate dehydrogenase iron-sulphur protein subunit\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_20200 fumarate reductase\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_14000 sdhC; succinate dehydrogenase 2 membrane subunit SdhC\tK00241 sdhC; succinate dehydrogenase cytochrome b subunit" }, { "name":"MSIM_14010 sdhD; succinate dehydrogenase\tK00242 sdhD; succinate dehydrogenase membrane anchor subunit" }, { "name":"MSIM_14910 gadB; glutamate decarboxylase\tK01580 E4.1.1.15; glutamate decarboxylase [EC:4.1.1.15]" }, { "name":"MSIM_03910 gabT; 4-aminobutyrate aminotransferase\tK07250 gabT; 4-aminobutyrate aminotransferase \/ (S)-3-amino-2-methylpropionate transaminase \/ 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]" }, { "name":"MSIM_20400 gabD1; succinate-semialdehyde dehydrogenase [NADP(+)] 1\tK00135 gabD; succinate-semialdehyde dehydrogenase \/ glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]" }, { "name":"MSIM_41720 korA; 2-oxoglutarate oxidoreductase subunit KorA\tK00174 korA; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_41730 korB; 2-oxoglutarate oxidoreductase subunit KorB\tK00175 korB; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_07070 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_10890 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_18900 succinyl-CoA--3-ketoacid-CoA transferase\tK01027 OXCT; 3-oxoacid CoA-transferase [EC:2.8.3.5]" }, { "name":"MSIM_42500 3-hydroxybutyrate dehydrogenase\tK00019 BDH1; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]" }, { "name":"MSIM_49440 methane monooxygenase\tK18223 prmA; propane 2-monooxygenase large subunit [EC:1.14.13.227]" }, { "name":"MSIM_49470 toluene hydroxylase\tK18224 prmC; propane 2-monooxygenase small subunit [EC:1.14.13.227]" }, { "name":"MSIM_49480 monooxygenase\tK18226 prmD; propane monooxygenase coupling protein" }, { "name":"MSIM_49460 methane monooxygenase component C\tK18225 prmB; propane monooxygenase reductase component [EC:1.18.1.-]" }, { "name":"MSIM_49490 alcohol dehydrogenase\tK18382 adh1; NAD+-dependent secondary alcohol dehydrogenase Adh1 [EC:1.1.1.-]" }, { "name":"MSIM_08320 ilvB1; acetolactate synthase large subunit IlvB1\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_15500 acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_20390 putative acetolactate synthase large subunit IlvB\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_22300 acetolactate synthase large subunit\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_29640 ilvX; putative acetolactate synthase large subunit IlvX\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_44650 alsS; acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_08310 ilvH; putative acetolactate synthase small subunit\tK01653 E2.2.1.6S; acetolactate synthase I\/III small subunit [EC:2.2.1.6]" }, { "name":"MSIM_44640 alpha-acetolactate decarboxylase\tK01575 alsD; acetolactate decarboxylase [EC:4.1.1.5]" }, { "name":"MSIM_36640 3-ketoacyl-ACP reductase\tK03366 butA; meso-butanediol dehydrogenase \/ (S,S)-butanediol dehydrogenase \/ diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304]" } ] }, { "name":"00660 C5-Branched dibasic acid metabolism [PATH:msim00660]", "children":[ { "name":"MSIM_08320 ilvB1; acetolactate synthase large subunit IlvB1\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_15500 acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_20390 putative acetolactate synthase large subunit IlvB\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_22300 acetolactate synthase large subunit\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_29640 ilvX; putative acetolactate synthase large subunit IlvX\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_44650 alsS; acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_08310 ilvH; putative acetolactate synthase small subunit\tK01653 E2.2.1.6S; acetolactate synthase I\/III small subunit [EC:2.2.1.6]" }, { "name":"MSIM_44640 alpha-acetolactate decarboxylase\tK01575 alsD; acetolactate decarboxylase [EC:4.1.1.5]" }, { "name":"MSIM_08950 sucC_1; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_34730 sucC_2; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_08940 succinyl-CoA synthetase subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_34740 succinate--CoA ligase [ADP-forming] subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_08190 leuC; 3-isopropylmalate dehydratase large subunit\tK01703 leuC; 3-isopropylmalate\/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]" }, { "name":"MSIM_08180 leuD; 3-isopropylmalate dehydratase small subunit\tK01704 leuD; 3-isopropylmalate\/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]" }, { "name":"MSIM_08250 leuB; 3-isopropylmalate dehydrogenase\tK00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]" } ] }, { "name":"00562 Inositol phosphate metabolism [PATH:msim00562]", "children":[ { "name":"MSIM_13880 acid phosphatase\tK21302 sapM; phosphatidylinositol-3-phosphatase [EC:3.1.3.64]" }, { "name":"MSIM_00960 impA; putative inositol 1-monophosphatase ImpA\tK01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]" }, { "name":"MSIM_04980 suhB; inositol-1-monophosphatase SuhB\tK01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]" }, { "name":"MSIM_24190 inositol monophosphatase\tK01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]" }, { "name":"MSIM_24360 hypothetical protein\tK01858 INO1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]" }, { "name":"MSIM_04170 pgsA1; CDP-diacylglycerol--inositol 3-phosphatidyltransferase\tK27681 pgsA; phosphatidylinositol phosphate synthase [EC:2.7.8.-]" }, { "name":"MSIM_15430 mmsA; methylmalonate-semialdehyde dehydrogenase (acylating)\tK00140 mmsA; malonate-semialdehyde dehydrogenase (acetylating) \/ methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]" }, { "name":"MSIM_02390 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]" } ] }, { "name":"00566 Sulfoquinovose metabolism", "children":[ { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" } ] } ] }, { "name":"09102 Energy metabolism", "children":[ { "name":"00190 Oxidative phosphorylation [PATH:msim00190]", "children":[ { "name":"MSIM_10940 nuoA; NADH-quinone oxidoreductase subunit A\tK00330 nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2]" }, { "name":"MSIM_10950 nuoB; NADH-quinone oxidoreductase subunit B\tK00331 nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2]" }, { "name":"MSIM_10960 nuoC; NADH-quinone oxidoreductase subunit C\tK00332 nuoC; NADH-quinone oxidoreductase subunit C [EC:7.1.1.2]" }, { "name":"MSIM_10970 nuoD; NADH-quinone oxidoreductase subunit D\tK00333 nuoD; NADH-quinone oxidoreductase subunit D [EC:7.1.1.2]" }, { "name":"MSIM_10980 nuoE; NADH-quinone oxidoreductase subunit E\tK00334 nuoE; NADH-quinone oxidoreductase subunit E [EC:7.1.1.2]" }, { "name":"MSIM_10990 nuoF; NADH-quinone oxidoreductase subunit F\tK00335 nuoF; NADH-quinone oxidoreductase subunit F [EC:7.1.1.2]" }, { "name":"MSIM_11000 nuoG; NADH-quinone oxidoreductase subunit G\tK00336 nuoG; NADH-quinone oxidoreductase subunit G [EC:7.1.1.2]" }, { "name":"MSIM_11010 nuoH; NADH-quinone oxidoreductase subunit H\tK00337 nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2]" }, { "name":"MSIM_11020 nuoI; NADH-quinone oxidoreductase subunit I\tK00338 nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2]" }, { "name":"MSIM_11030 nuoJ; NADH-quinone oxidoreductase subunit J\tK00339 nuoJ; NADH-quinone oxidoreductase subunit J [EC:7.1.1.2]" }, { "name":"MSIM_11040 nuoK; NADH-quinone oxidoreductase subunit K\tK00340 nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2]" }, { "name":"MSIM_11050 nuoL; NADH-quinone oxidoreductase subunit L\tK00341 nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2]" }, { "name":"MSIM_11060 nuoM; NADH-quinone oxidoreductase subunit M\tK00342 nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2]" }, { "name":"MSIM_11070 nuoN; NADH-quinone oxidoreductase subunit N\tK00343 nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2]" }, { "name":"MSIM_11700 hypothetical protein\tK03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]" }, { "name":"MSIM_18770 ndhA; NADH dehydrogenase NdhA\tK03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]" }, { "name":"MSIM_33440 dehydrogenase\tK03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]" }, { "name":"MSIM_36160 dehydrogenase\tK03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]" }, { "name":"MSIM_51450 ndh; NADH dehydrogenase\tK03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]" }, { "name":"MSIM_51950 NADH dehydrogenase\tK03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9]" }, { "name":"MSIM_14020 sdhA; succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_20190 succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_14030 sdhB; succinate dehydrogenase iron-sulphur protein subunit\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_20200 fumarate reductase\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_14000 sdhC; succinate dehydrogenase 2 membrane subunit SdhC\tK00241 sdhC; succinate dehydrogenase cytochrome b subunit" }, { "name":"MSIM_14010 sdhD; succinate dehydrogenase\tK00242 sdhD; succinate dehydrogenase membrane anchor subunit" }, { "name":"MSIM_45910 qcrA; cytochrome bc1 complex Rieske iron-sulfur subunit\tK03890 qcrA; quinol---cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]" }, { "name":"MSIM_45900 qcrB; cytochrome bc1 complex cytochrome b subunit\tK03891 qcrB; quinol---cytochrome-c reductase cytochrome b subunit [EC:7.1.1.8]" }, { "name":"MSIM_45920 qcrC; cytochrome bc1 complex cytochrome c subunit\tK03889 qcrC; quinol---cytochrome-c reductase cytochrome c subunit [EC:7.1.1.8]" }, { "name":"MSIM_02290 ctaB; protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]" }, { "name":"MSIM_45850 ctaF; putative cytochrome c oxidase polypeptide 4\tK27109 ctaF; cytochrome c oxidase subunit IV [EC:7.1.1.9]" }, { "name":"MSIM_45930 ctaE_2; putative cytochrome c oxidase subunit 3\tK02276 coxC; cytochrome c oxidase subunit III [EC:7.1.1.9]" }, { "name":"MSIM_08860 ctaD_1; putative cytochrome c oxidase subunit 1\tK02274 coxA; cytochrome c oxidase subunit I [EC:7.1.1.9]" }, { "name":"MSIM_33420 ctaD_2; cytochrome c oxidase subunit 1\tK02274 coxA; cytochrome c oxidase subunit I [EC:7.1.1.9]" }, { "name":"MSIM_45840 ctaC; putative cytochrome c oxidase subunit 2\tK02275 coxB; cytochrome c oxidase subunit II [EC:7.1.1.9]" }, { "name":"MSIM_02250 heme A synthase\tK02259 COX15; heme a synthase [EC:1.17.99.9]" }, { "name":"MSIM_00750 cydA; cytochrome ubiquinol oxidase subunit I\tK00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7]" }, { "name":"MSIM_00760 cydB; cytochrome c oxidase assembly protein\tK00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7]" }, { "name":"MSIM_39750 atpA; ATP synthase subunit alpha\tK02111 ATPF1A; F-type H+\/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]" }, { "name":"MSIM_39770 atpD; ATP synthase subunit beta\tK02112 ATPF1B; F-type H+\/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]" }, { "name":"MSIM_39760 atpG; ATP synthase gamma chain\tK02115 ATPF1G; F-type H+-transporting ATPase subunit gamma" }, { "name":"MSIM_39740 atpFH; ATP synthase subunit b-delta\tK02109 ATPF0B; F-type H+-transporting ATPase subunit b" }, { "name":"MSIM_39780 atpC; ATP synthase epsilon chain\tK02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon" }, { "name":"MSIM_39710 atpB; ATP synthase subunit a\tK02108 ATPF0A; F-type H+-transporting ATPase subunit a" }, { "name":"MSIM_39730 atpF; ATP synthase subunit b\tK02109 ATPF0B; F-type H+-transporting ATPase subunit b" }, { "name":"MSIM_39720 atpE; ATP synthase subunit c\tK02110 ATPF0C; F-type H+-transporting ATPase subunit c" }, { "name":"MSIM_28360 ppa; inorganic pyrophosphatase\tK01507 ppa; inorganic pyrophosphatase [EC:3.6.1.1]" }, { "name":"MSIM_08150 ppk; polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]" }, { "name":"MSIM_12750 ppk2; polyphosphate kinase\tK22468 ppk2; polyphosphate kinase [EC:2.7.4.34]" } ] }, { "name":"00195 Photosynthesis" }, { "name":"00196 Photosynthesis - antenna proteins" }, { "name":"00710 Carbon fixation by Calvin cycle [PATH:msim00710]", "children":[ { "name":"MSIM_02400 pgk; phosphoglycerate kinase\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]" }, { "name":"MSIM_02410 gap; glyceraldehyde-3-phosphate dehydrogenase\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_18880 fba; fructose-bisphosphate aldolase\tK01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]" }, { "name":"MSIM_37350 glpX; fructose-1,6-bisphosphatase class 2\tK02446 glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]" }, { "name":"MSIM_02300 tkt; transketolase\tK00615 E2.2.1.1; transketolase [EC:2.2.1.1]" }, { "name":"MSIM_41630 rpiB; ribose-5-phosphate isomerase B\tK01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]" }, { "name":"MSIM_02390 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]" }, { "name":"MSIM_02620 rpe; ribulose-phosphate 3-epimerase\tK01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]" }, { "name":"MSIM_02310 tal_1; transaldolase\tK00616 TALDO1; transaldolase [EC:2.2.1.2]" }, { "name":"MSIM_33410 tal_2; transaldolase\tK00616 TALDO1; transaldolase [EC:2.2.1.2]" }, { "name":"MSIM_02370 ppc; phosphoenolpyruvate carboxylase\tK01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]" }, { "name":"MSIM_37650 ppdK; pyruvate, phosphate dikinase\tK01006 ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]" }, { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" } ] }, { "name":"00720 Other carbon fixation pathways [PATH:msim00720]", "children":[ { "name":"MSIM_37650 ppdK; pyruvate, phosphate dikinase\tK01006 ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]" }, { "name":"MSIM_02370 ppc; phosphoenolpyruvate carboxylase\tK01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]" }, { "name":"MSIM_07950 pca; pyruvate carboxylase\tK01958 PC; pyruvate carboxylase [EC:6.4.1.1]" }, { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" }, { "name":"MSIM_37340 fumC; fumarate hydratase\tK01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2]" }, { "name":"MSIM_14020 sdhA; succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_20190 succinate dehydrogenase flavoprotein subunit\tK00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1]" }, { "name":"MSIM_14030 sdhB; succinate dehydrogenase iron-sulphur protein subunit\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_20200 fumarate reductase\tK00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1]" }, { "name":"MSIM_14000 sdhC; succinate dehydrogenase 2 membrane subunit SdhC\tK00241 sdhC; succinate dehydrogenase cytochrome b subunit" }, { "name":"MSIM_14010 sdhD; succinate dehydrogenase\tK00242 sdhD; succinate dehydrogenase membrane anchor subunit" }, { "name":"MSIM_08940 succinyl-CoA synthetase subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_34740 succinate--CoA ligase [ADP-forming] subunit alpha\tK01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]" }, { "name":"MSIM_08950 sucC_1; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_34730 sucC_2; succinate--CoA ligase [ADP-forming] subunit beta\tK01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_41720 korA; 2-oxoglutarate oxidoreductase subunit KorA\tK00174 korA; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_41730 korB; 2-oxoglutarate oxidoreductase subunit KorB\tK00175 korB; 2-oxoglutarate\/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]" }, { "name":"MSIM_14170 icd2; isocitrate dehydrogenase, NADP-dependent\tK00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]" }, { "name":"MSIM_02070 acn; aconitate hydratase\tK27802 acnA; aconitate hydratase A \/ 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]" }, { "name":"MSIM_12340 biotinylated protein TB7.3\tK02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein" }, { "name":"MSIM_34110 enoyl-CoA hydratase\tK15019 K15019; 3-hydroxypropionyl-coenzyme A dehydratase [EC:4.2.1.116]" }, { "name":"MSIM_40220 dehydratase\tK14470 mct; 2-methylfumaryl-CoA isomerase [EC:5.4.1.3]" }, { "name":"MSIM_39880 methylmalonyl-CoA epimerase\tK05606 MCEE; methylmalonyl-CoA\/ethylmalonyl-CoA epimerase [EC:5.1.99.1]" }, { "name":"MSIM_01870 mutB; putative methylmalonyl-CoA mutase large subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_01880 mutA; putative methylmalonyl-CoA mutase small subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_31320 methylmalonyl-CoA mutase\tK01848 E5.4.99.2A; methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_31330 methylmalonyl-CoA mutase\tK01849 E5.4.99.2B; methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_14280 folD; bifunctional protein FolD\tK01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) \/ methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]" }, { "name":"MSIM_18620 pta; phosphate acetyltransferase\tK13788 pta; phosphate acetyltransferase [EC:2.3.1.8]" }, { "name":"MSIM_18610 ackA; acetate kinase\tK00925 ackA; acetate kinase [EC:2.7.2.1]" }, { "name":"MSIM_28060 acsA; acetyl-coenzyme A synthetase\tK01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]" } ] }, { "name":"00680 Methane metabolism [PATH:msim00680]", "children":[ { "name":"MSIM_30180 adhB; alcohol dehydrogenase B\tK00121 frmA; S-(hydroxymethyl)glutathione dehydrogenase \/ alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]" }, { "name":"MSIM_06190 formate dehydrogenase\tK00122 FDH; formate dehydrogenase [EC:1.17.1.9]" }, { "name":"MSIM_23350 formate dehydrogenase subunit alpha\tK00123 fdoG; formate dehydrogenase major subunit [EC:1.17.1.9]" }, { "name":"MSIM_23340 4Fe-4S ferredoxin\tK00124 fdoH; formate dehydrogenase iron-sulfur subunit" }, { "name":"MSIM_37280 glyA1; serine hydroxymethyltransferase 1\tK00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]" }, { "name":"MSIM_36760 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"MSIM_02370 ppc; phosphoenolpyruvate carboxylase\tK01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]" }, { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_18880 fba; fructose-bisphosphate aldolase\tK01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]" }, { "name":"MSIM_37350 glpX; fructose-1,6-bisphosphatase class 2\tK02446 glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]" }, { "name":"MSIM_08380 pfkA; ATP-dependent 6-phosphofructokinase\tK21071 pfk; ATP-dependent phosphofructokinase \/ diphosphate-dependent phosphofructokinase [EC:2.7.1.11 2.7.1.90]" }, { "name":"MSIM_28430 glutamine amidotransferase\tK22081 mgsA; methylamine---glutamate N-methyltransferase subunit A [EC:2.1.1.21]" }, { "name":"MSIM_28440 protein glxC\tK22082 mgsB; methylamine---glutamate N-methyltransferase subunit B [EC:2.1.1.21]" }, { "name":"MSIM_28450 FMN-binding glutamate synthase family protein\tK22083 mgsC; methylamine---glutamate N-methyltransferase subunit C [EC:2.1.1.21]" }, { "name":"MSIM_14700 5,10-methylenetetrahydromethanopterin reductase\tK00320 mer; 5,10-methylenetetrahydromethanopterin reductase [EC:1.5.98.2]" }, { "name":"MSIM_18610 ackA; acetate kinase\tK00925 ackA; acetate kinase [EC:2.7.2.1]" }, { "name":"MSIM_18620 pta; phosphate acetyltransferase\tK13788 pta; phosphate acetyltransferase [EC:2.3.1.8]" }, { "name":"MSIM_28060 acsA; acetyl-coenzyme A synthetase\tK01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]" }, { "name":"MSIM_17650 gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]" }, { "name":"MSIM_08260 serA; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_15610 serA2; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_35770 D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_33010 serC; putative phosphoserine aminotransferase\tK00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]" }, { "name":"MSIM_08850 phosphoserine phosphatase SerB\tK01079 serB; phosphoserine phosphatase [EC:3.1.3.3]" }, { "name":"MSIM_38270 fbiC; FO synthase\tK11779 fbiC; FO synthase [EC:2.5.1.147 4.3.1.32]" }, { "name":"MSIM_08140 cofC; 2-phospho-L-lactate guanylyltransferase\tK14941 cofC; 2-phospho-L-lactate\/phosphoenolpyruvate guanylyltransferase [EC:2.7.7.68 2.7.7.105]" }, { "name":"MSIM_13080 cofD; 2-phospho-L-lactate transferase\tK11212 cofD; LPPG:FO 2-phospho-L-lactate transferase [EC:2.7.8.28]" }, { "name":"MSIM_13090 fbiB; coenzyme F420:L-glutamate ligase\tK24998 fbiB; dehydro coenzyme F420 reductase \/ coenzyme F420-0:L-glutamate ligase \/ coenzyme F420-1:gamma-L-glutamate ligase [EC:1.3.8.17 6.3.2.31 6.3.2.34]" } ] }, { "name":"00910 Nitrogen metabolism [PATH:msim00910]", "children":[ { "name":"MSIM_09890 formamidase\tK01455 fmdA; formamidase [EC:3.5.1.49]" }, { "name":"MSIM_20060 narK3_1; MFS transporter\tK02575 NRT2; MFS transporter, NNP family, nitrate\/nitrite transporter" }, { "name":"MSIM_20070 narK3_2; MFS transporter\tK02575 NRT2; MFS transporter, NNP family, nitrate\/nitrite transporter" }, { "name":"MSIM_20940 narK3_3; MFS transporter\tK02575 NRT2; MFS transporter, NNP family, nitrate\/nitrite transporter" }, { "name":"MSIM_20120 nirB; nitrite reductase large subunit\tK00362 nirB; nitrite reductase (NADH) large subunit [EC:1.7.1.15]" }, { "name":"MSIM_20110 nirD; nitrite reductase small subunit\tK00363 nirD; nitrite reductase (NADH) small subunit [EC:1.7.1.15]" }, { "name":"MSIM_04230 2-nitropropane dioxygenase\tK00459 ncd2; nitronate monooxygenase [EC:1.13.12.16]" }, { "name":"MSIM_05870 oxidoreductase\tK00459 ncd2; nitronate monooxygenase [EC:1.13.12.16]" }, { "name":"MSIM_12850 oxidoreductase\tK00459 ncd2; nitronate monooxygenase [EC:1.13.12.16]" }, { "name":"MSIM_50570 hypothetical 2-nitropropane dioxygenase\tK00459 ncd2; nitronate monooxygenase [EC:1.13.12.16]" }, { "name":"MSIM_52790 oxidoreductase\tK00459 ncd2; nitronate monooxygenase [EC:1.13.12.16]" }, { "name":"MSIM_20980 nitrilase\tK01501 E3.5.5.1; nitrilase [EC:3.5.5.1]" }, { "name":"MSIM_41520 gdh; NAD-glutamate dehydrogenase\tK15371 GDH2; glutamate dehydrogenase [EC:1.4.1.2]" }, { "name":"MSIM_28420 glnT; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45490 glnA2; putative glutamine synthetase 2\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45600 glnA1; glutamine synthetase 1\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51050 glnA3; glutamine synthetase GlnA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51550 type III glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_53180 glnN; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_25450 gltB; glutamate synthase\tK00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]" }, { "name":"MSIM_25460 gltD; glutamate synthase [NADPH] small chain\tK00266 gltD; glutamate synthase (NADPH) small chain [EC:1.4.1.13]" }, { "name":"MSIM_16620 cynS; cyanate hydratase\tK01725 cynS; cyanate lyase [EC:4.2.1.104]" }, { "name":"MSIM_02650 hypothetical protein\tK01673 cynT; carbonic anhydrase [EC:4.2.1.1]" }, { "name":"MSIM_13480 carbonic anhydrase\tK01673 cynT; carbonic anhydrase [EC:4.2.1.1]" }, { "name":"MSIM_28800 carbonic anhydrase\tK01673 cynT; carbonic anhydrase [EC:4.2.1.1]" }, { "name":"MSIM_39410 hypothetical protein\tK01673 cynT; carbonic anhydrase [EC:4.2.1.1]" } ] }, { "name":"00920 Sulfur metabolism [PATH:msim00920]", "children":[ { "name":"MSIM_42370 subI; sulfate ABC transporter substrate-binding protein\tK23163 sbp; sulfate\/thiosulfate transport system substrate-binding protein" }, { "name":"MSIM_42380 cysT; sulfate ABC transporter permease subunit CysT\tK02046 cysU; sulfate\/thiosulfate transport system permease protein" }, { "name":"MSIM_42390 cysW; sulfate ABC transporter permease CysW\tK02047 cysW; sulfate\/thiosulfate transport system permease protein" }, { "name":"MSIM_42400 cysA; sulfate\/thiosulfate import ATP-binding protein CysA\tK02045 cysA; sulfate\/thiosulfate transport system ATP-binding protein [EC:7.3.2.3]" }, { "name":"MSIM_03170 putative nitrate ABC transporter, periplasmic protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_23240 aliphatic sulfonate ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_23730 ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_32730 ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_03160 putative nitrate ABC transporter, permease protein\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_23220 sulfate ABC transporter permease\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_23720 putative nitrate ABC transporter, permease protein\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_32750 ABC transporter permease\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_03150 putative nitrate ABC transporter, ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_23230 ABC transporter ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_23710 ABC transporter ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_32740 ssuB; aliphatic sulfonates import ATP-binding protein SsuB\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_17290 alkanesulfonate monooxygenase\tK04091 ssuD; alkanesulfonate monooxygenase [EC:1.14.14.5 1.14.14.34]" }, { "name":"MSIM_23450 putative alkanesulfonate monooxygenase\tK04091 ssuD; alkanesulfonate monooxygenase [EC:1.14.14.5 1.14.14.34]" }, { "name":"MSIM_38360 adenylyl-sulfate kinase\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_39440 cysNC; bifunctional enzyme CysN\/CysC\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_38370 sulfate adenylyltransferase\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_39430 cysD; sulfate adenylyltransferase subunit 2\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_44420 3'(2'),5'-bisphosphate nucleotidase CysQ\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]" }, { "name":"MSIM_46860 cysQ; 3'-phosphoadenosine 5'-phosphate phosphatase\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]" }, { "name":"MSIM_06300 phosphoesterase\tK06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]" }, { "name":"MSIM_42430 cysH; putative phosphoadenosine phosphosulfate reductase\tK00390 cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10]" }, { "name":"MSIM_29980 putative sulfite reductase\tK00380 cysJ; sulfite reductase (NADPH) flavoprotein alpha-component [EC:1.8.1.2]" }, { "name":"MSIM_43180 bifunctional reductase\tK00380 cysJ; sulfite reductase (NADPH) flavoprotein alpha-component [EC:1.8.1.2]" }, { "name":"MSIM_42440 sir; sulfite reductase [ferredoxin]\tK00392 sir; sulfite reductase (ferredoxin) [EC:1.8.7.1]" }, { "name":"MSIM_13620 sseA; putative thiosulfate sulfurtransferase SseA\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_30960 cysA2; thiosulfate sulfurtransferase CysA\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_44610 sseB; putative thiosulfate sulfurtransferase SseB\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_42980 cysE; serine acetyltransferase\tK00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]" }, { "name":"MSIM_42990 cysK; O-acetylserine sulfhydrylase\tK01738 cysK; cysteine synthase [EC:2.5.1.47]" }, { "name":"MSIM_14190 metX; homoserine O-acetyltransferase\tK00641 metX; homoserine O-acetyltransferase\/O-succinyltransferase [EC:2.3.1.31 2.3.1.46]" }, { "name":"MSIM_39570 homoserine O-acetyltransferase\tK00641 metX; homoserine O-acetyltransferase\/O-succinyltransferase [EC:2.3.1.31 2.3.1.46]" }, { "name":"MSIM_37140 metB; cystathionine gamma-synthase\tK01739 metB; cystathionine gamma-synthase [EC:2.5.1.48]" }, { "name":"MSIM_18780 metZ; O-succinylhomoserine sulfhydrylase\tK10764 metZ; O-succinylhomoserine sulfhydrylase [EC:2.5.1.-]" }, { "name":"MSIM_12780 membrane protein\tK21310 mddA; methanethiol S-methyltransferase [EC:2.1.1.334]" } ] } ] }, { "name":"09103 Lipid metabolism", "children":[ { "name":"00061 Fatty acid biosynthesis [PATH:msim00061]", "children":[ { "name":"MSIM_12340 biotinylated protein TB7.3\tK02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein" }, { "name":"MSIM_13640 acetyl-\/propionyl-CoA carboxylase subunit alpha\tK11263 bccA; acetyl-CoA\/propionyl-CoA\/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]" }, { "name":"MSIM_45140 accD6; putative propionyl-CoA carboxylase beta chain 6\tK18472 accD6; acetyl-CoA\/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]" }, { "name":"MSIM_40080 mbtL; acyl carrier protein MbtL\tK02078 acpP; acyl carrier protein" }, { "name":"MSIM_45170 acpM; meromycolate extension acyl carrier protein\tK02078 acpP; acyl carrier protein" }, { "name":"MSIM_16370 fabD2; malonyl CoA-ACP transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_45180 fabD; malonyl CoA-acyl carrier protein transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_40990 fas; type I polyketide synthase\tK11533 fas; fatty acid synthase, bacteria type [EC:2.3.1.-]" }, { "name":"MSIM_13360 hypothetical protein\tK00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]" }, { "name":"MSIM_15480 3-oxoacyl-ACP synthase\tK00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]" }, { "name":"MSIM_12430 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_20250 fabG4; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_22950 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_31770 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34040 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34210 fabG_3; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34260 3-ketoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35190 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35590 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35600 hypothetical protein\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_40200 fabG2; putative oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_50220 putative 2-nitropropane dioxygenase, NPD\tK02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]" }, { "name":"MSIM_31090 desA1_1; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_53420 desA1_2; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_37290 desA2; acyl-ACP desaturase\tK03922 desA2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.-]" }, { "name":"MSIM_35640 hypothetical protein\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_43580 AMP-dependent ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_45990 long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_29220 oxidoreductase\tK28220 scdG; hydroxylacyl dehydrogenase [EC:1.1.-.-]" } ] }, { "name":"00062 Fatty acid elongation" }, { "name":"00071 Fatty acid degradation [PATH:msim00071]", "children":[ { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_05960 ltp1; lipid-transfer protein\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_12520 acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29240 fadA6; acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29330 fadA5; steroid 3-ketoacyl-CoA thiolase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_31960 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_37930 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_43200 acyl-CoA oxidase\tK00232 ACOX1_3; acyl-CoA oxidase [EC:1.3.3.6]" }, { "name":"MSIM_09570 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_10820 fadE23; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_10910 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_20430 fadE4; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_21710 fadE2; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_22060 fadE1; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_23390 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_24700 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_26430 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_31940 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_34890 fadE13; acyl-CoA dehydrogenase FadE13\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_05200 fadE20; acyl-CoA dehydrogenase FadE20\tK00255 ACADL; long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]" }, { "name":"MSIM_18730 acyl-CoA dehydrogenase\tK00255 ACADL; long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]" }, { "name":"MSIM_18720 fadE7; acyl-CoA dehydrogenase\tK00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]" }, { "name":"MSIM_35640 hypothetical protein\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_43580 AMP-dependent ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_45990 long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_40090 mbtM; long-chain-fatty-acid--[acyl-carrier-protein] ligase MbtM\tK01909 mbtM; long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:6.2.1.20]" }, { "name":"MSIM_12980 alkB; alkane 1-monooxygenase AlkB\tK00496 alkB1_2; alkane 1-monooxygenase [EC:1.14.15.3]" }, { "name":"MSIM_51260 reductase\tK00529 hcaD; 3-phenylpropionate\/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]" }, { "name":"MSIM_30180 adhB; alcohol dehydrogenase B\tK00121 frmA; S-(hydroxymethyl)glutathione dehydrogenase \/ alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]" }, { "name":"MSIM_09660 alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_51380 adhA; alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" } ] }, { "name":"00073 Cutin, suberine and wax biosynthesis [PATH:msim00073]", "children":[ { "name":"MSIM_14480 acrA1; short chain dehydrogenase\tK28138 acrB; alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84]" }, { "name":"MSIM_00480 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_02460 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_12760 tgs3; diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_14440 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_20580 putative diacyglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_26820 tgs2; putative diacyglycerol O-acyltransferase tgs2\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_30600 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_41430 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_45450 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" } ] }, { "name":"00074 Mycolic acid biosynthesis [PATH:msim00074]", "children":[ { "name":"MSIM_13640 acetyl-\/propionyl-CoA carboxylase subunit alpha\tK11263 bccA; acetyl-CoA\/propionyl-CoA\/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]" }, { "name":"MSIM_45140 accD6; putative propionyl-CoA carboxylase beta chain 6\tK18472 accD6; acetyl-CoA\/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]" }, { "name":"MSIM_41000 acpS; holo-[acyl-carrier-protein] synthase\tK00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]" }, { "name":"MSIM_05990 4'-phosphopantetheinyl transferase\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]" }, { "name":"MSIM_40080 mbtL; acyl carrier protein MbtL\tK02078 acpP; acyl carrier protein" }, { "name":"MSIM_45170 acpM; meromycolate extension acyl carrier protein\tK02078 acpP; acyl carrier protein" }, { "name":"MSIM_16370 fabD2; malonyl CoA-ACP transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_45180 fabD; malonyl CoA-acyl carrier protein transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_40990 fas; type I polyketide synthase\tK11533 fas; fatty acid synthase, bacteria type [EC:2.3.1.-]" }, { "name":"MSIM_17160 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase 3\tK11608 mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier protein] synthase III [EC:2.3.1.301]" }, { "name":"MSIM_45160 kasA; 3-oxoacyl-[acyl-carrier-protein] synthase 1\tK11609 kasA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase I [EC:2.3.1.293]" }, { "name":"MSIM_14500 kasB_1; 3-oxoacyl-[acyl-carrier-protein] synthase 2\tK27070 kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC:2.3.1.294]" }, { "name":"MSIM_45150 kasB_2; 3-oxoacyl-[acyl-carrier-protein] synthase 2\tK27070 kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC:2.3.1.294]" }, { "name":"MSIM_01970 fabG_1; 3-oxoacyl-[acyl-carrier-protein] reductase FabG\tK11610 mabA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]" }, { "name":"MSIM_16550 UPF0336 protein\tK27071 hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]" }, { "name":"MSIM_16540 hadB; (3R)-hydroxyacyl-ACP dehydratase subunit HadB\tK27072 hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]" }, { "name":"MSIM_23930 (R)-hydratase\tK27689 hadAB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-]" }, { "name":"MSIM_16530 UPF0336 protein\tK27073 hadC; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadC [EC:4.2.1.-]" }, { "name":"MSIM_17480 UPF0336 protein\tK27074 hadD; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadD [EC:4.2.1.-]" }, { "name":"MSIM_01960 inhA; enoyl-[acyl-carrier-protein] reductase [NADH]\tK11611 inhA; meromycolic acid enoyl-[acyl-carrier protein] reductase [EC:1.3.1.118]" }, { "name":"MSIM_31090 desA1_1; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_53420 desA1_2; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_37290 desA2; acyl-ACP desaturase\tK03922 desA2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.-]" }, { "name":"MSIM_17820 umaA1; SAM-dependent methyltransferase\tK26590 umaA; mycolic acid methyltransferase UmaA [EC:2.1.1.-]" }, { "name":"MSIM_17810 umaA2; SAM-dependent methyltransferase\tK26591 pcaA; cyclopropane mycolic acid synthase PcaA" }, { "name":"MSIM_16460 mmaA4; hydroxymycolate synthase MmaA4\tK26592 mmaA4; hydroxy mycolic acid synthase MmaA4" }, { "name":"MSIM_16450 cmaB_1; methoxy mycolic acid synthase MmaA3\tK26593 mmaA3; methoxy mycolic acid synthase MmaA3" }, { "name":"MSIM_16440 mmaA2_2; cyclopropane mycolic acid synthase MmaA2\tK26595 mmaA2; cyclopropane mycolic acid synthase MmaA2" }, { "name":"MSIM_38190 mmaA2_4; cyclopropane mycolic acid synthase MmaA2\tK26595 mmaA2; cyclopropane mycolic acid synthase MmaA2" }, { "name":"MSIM_16420 cmaD; mycolic acid methyltransferase MmaA1\tK26594 mmaA1; mycolic acid methyltransferase MmaA1 [EC:2.1.1.-]" }, { "name":"MSIM_17490 cmaA2; cyclopropane mycolic acid synthase 2\tK26596 cmaA2; cyclopropane mycolic acid synthase CmaA2" }, { "name":"MSIM_22050 fgd2; F420-dependent hydroxymycolic acid dehydrogenase\tK00120 fgd2; F420-dependent hydroxymycolic acid dehydrogenase [EC:1.1.98.-]" }, { "name":"MSIM_26000 accD4; propionyl-CoA carboxylase subunit beta\tK27093 accD4; long-chain acyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.- 2.1.3.-]" }, { "name":"MSIM_13590 accD5; putative propionyl-CoA carboxylase beta chain 5\tK27094 accD5; propionyl-CoA\/long-chain acyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.3 6.4.1.- 2.1.3.15]" }, { "name":"MSIM_13600 hypothetical protein\tK27095 accE5; acyl-CoA carboxylase epsilon subunit" }, { "name":"MSIM_25980 fadD32; long-chain-fatty-acid--AMP ligase FadD32\tK12428 fadD32; fatty acyl-AMP ligase FadD32 [EC:6.2.1.-]" }, { "name":"MSIM_25990 pks13; polyketide synthase\tK12437 pks13; polyketide synthase 13" }, { "name":"MSIM_41220 short-chain type dehydrogenase\/reductase\tK27306 cmrA; mycolic acid reductase" }, { "name":"MSIM_22120 fbpC; diacylglycerol acyltransferase\/mycolyltransferase Ag85C\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_25950 fbpA; diacylglycerol acyltransferase\/mycolyltransferase Ag85A\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_50860 fbpB; diacylglycerol acyltransferase\/mycolyltransferase Ag85B\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_13840 cutinase\tK27308 tdmh; trehalose dimycolate hydrolase" }, { "name":"MSIM_15160 hypothetical protein\tK27359 cut3; trehalose dimycolate hydrolase" } ] }, { "name":"00100 Steroid biosynthesis [PATH:msim00100]", "children":[ { "name":"MSIM_30210 cytochrome P450\tK05917 CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]" } ] }, { "name":"00120 Primary bile acid biosynthesis" }, { "name":"00121 Secondary bile acid biosynthesis [PATH:msim00121]", "children":[ { "name":"MSIM_11130 short-chain dehydrogenase\tK00076 hdhA; 7-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.159]" }, { "name":"MSIM_34450 oxidoreductase\tK00076 hdhA; 7-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.159]" }, { "name":"MSIM_47800 putative short chain dehydrogenase\/reductase\tK00076 hdhA; 7-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.159]" }, { "name":"MSIM_20450 AMP-dependent synthetase\tK15868 baiB; bile acid-coenzyme A ligase [EC:6.2.1.7]" }, { "name":"MSIM_40770 AMP-dependent synthetase\tK15868 baiB; bile acid-coenzyme A ligase [EC:6.2.1.7]" } ] }, { "name":"00140 Steroid hormone biosynthesis" }, { "name":"00561 Glycerolipid metabolism [PATH:msim00561]", "children":[ { "name":"MSIM_06080 glxK; glycerate kinase\tK00865 glxK; glycerate 2-kinase [EC:2.7.1.165]" }, { "name":"MSIM_45790 hypothetical protein\tK00865 glxK; glycerate 2-kinase [EC:2.7.1.165]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_08880 adhC; NADP-dependent alcohol dehydrogenase C\tK13979 yahK; alcohol dehydrogenase (NADP+) [EC:1.1.1.2]" }, { "name":"MSIM_27520 glpK; glycerol kinase\tK00864 glpK; glycerol kinase [EC:2.7.1.30]" }, { "name":"MSIM_54100 phosphatase\tK06117 E3.1.3.21; glycerol-1-phosphatase [EC:3.1.3.21]" }, { "name":"MSIM_01320 plsB1; putative acyltransferase plsB1\tK00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]" }, { "name":"MSIM_41450 plsB; glycerol-3-phosphate acyltransferase\tK00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]" }, { "name":"MSIM_10080 hypothetical protein\tK00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]" }, { "name":"MSIM_46040 1-acyl-sn-glycerol-3-phosphate acyltransferase\tK00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]" }, { "name":"MSIM_45090 dagK; diacylglycerol kinase\tK07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107]" }, { "name":"MSIM_00480 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_02460 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_12760 tgs3; diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_14440 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_20580 putative diacyglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_26820 tgs2; putative diacyglycerol O-acyltransferase tgs2\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_30600 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_41430 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_45450 diacylglycerol O-acyltransferase\tK00635 tgs; wax synthase \/ diacylglycerol O-acyltransferase [EC:2.3.1.75 2.3.1.20]" }, { "name":"MSIM_22120 fbpC; diacylglycerol acyltransferase\/mycolyltransferase Ag85C\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_25950 fbpA; diacylglycerol acyltransferase\/mycolyltransferase Ag85A\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_50860 fbpB; diacylglycerol acyltransferase\/mycolyltransferase Ag85B\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_41270 hypothetical protein\tK01046 lip; triacylglycerol lipase [EC:3.1.1.3]" }, { "name":"MSIM_21080 monoacylglycerol lipase\tK01054 MGLL; acylglycerol lipase [EC:3.1.1.23]" } ] }, { "name":"00564 Glycerophospholipid metabolism [PATH:msim00564]", "children":[ { "name":"MSIM_08130 gpsA; glycerol-3-phosphate dehydrogenase [NAD(P)+]\tK00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]" }, { "name":"MSIM_16820 gpsA2; putative glycerol-3-phosphate dehydrogenase 2 [NAD(P)+]\tK00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]" }, { "name":"MSIM_13780 glpD2; glycerol-3-phosphate dehydrogenase 2\tK00111 glpA; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]" }, { "name":"MSIM_45120 glpD1; glycerol-3-phosphate dehydrogenase 1\tK00111 glpA; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]" }, { "name":"MSIM_01320 plsB1; putative acyltransferase plsB1\tK00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]" }, { "name":"MSIM_41450 plsB; glycerol-3-phosphate acyltransferase\tK00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]" }, { "name":"MSIM_10080 hypothetical protein\tK00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]" }, { "name":"MSIM_46040 1-acyl-sn-glycerol-3-phosphate acyltransferase\tK00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]" }, { "name":"MSIM_45090 dagK; diacylglycerol kinase\tK07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107]" }, { "name":"MSIM_25640 glpQ1; putative glycerophosphoryl diester phosphodiesterase 1\tK01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]" }, { "name":"MSIM_28910 putative glycerophosphoryl diester phosphodiesterase precursor (GlpQ)\tK01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]" }, { "name":"MSIM_50060 glpQ2; glycerophosphoryl diester phosphodiesterase\tK01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]" }, { "name":"MSIM_18920 putative ethanolamine ammonia-lyase, heavy subunit\tK03735 eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]" }, { "name":"MSIM_18930 eutC; ethanolamine ammonia-lyase light chain\tK03736 eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]" }, { "name":"MSIM_06840 cdsA; phosphatidate cytidylyltransferase\tK00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41]" }, { "name":"MSIM_10090 hypothetical protein\tK00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41]" }, { "name":"MSIM_18200 pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase\tK17103 CHO1; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]" }, { "name":"MSIM_18190 psd; phosphatidylserine decarboxylase proenzyme\tK01613 psd; phosphatidylserine decarboxylase [EC:4.1.1.65]" }, { "name":"MSIM_05380 pgsA3; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase\tK00995 PGS1; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]" }, { "name":"MSIM_51850 pgsA2; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase\tK08744 CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41]" } ] }, { "name":"00565 Ether lipid metabolism", "children":[ { "name":"MSIM_45100 flavoprotein\tK00803 AGPS; alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]" } ] }, { "name":"00600 Sphingolipid metabolism", "children":[ { "name":"MSIM_23770 sulfatase\tK01130 atsA; arylsulfatase [EC:3.1.6.1]" }, { "name":"MSIM_52780 atsA_2; arylsulfatase\tK01130 atsA; arylsulfatase [EC:3.1.6.1]" } ] }, { "name":"00590 Arachidonic acid metabolism" }, { "name":"00591 Linoleic acid metabolism" }, { "name":"00592 alpha-Linolenic acid metabolism [PATH:msim00592]", "children":[ { "name":"MSIM_43200 acyl-CoA oxidase\tK00232 ACOX1_3; acyl-CoA oxidase [EC:1.3.3.6]" }, { "name":"MSIM_05960 ltp1; lipid-transfer protein\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_12520 acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29240 fadA6; acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29330 fadA5; steroid 3-ketoacyl-CoA thiolase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_31960 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_37930 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" } ] }, { "name":"01040 Biosynthesis of unsaturated fatty acids [PATH:msim01040]", "children":[ { "name":"MSIM_31090 desA1_1; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_53420 desA1_2; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_37290 desA2; acyl-ACP desaturase\tK03922 desA2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.-]" }, { "name":"MSIM_00460 stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_12710 stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_12720 stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_22010 fatty acid desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_40130 desA3; NADPH-dependent stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_12730 NADPH oxidoreductase\tK22770 K22770; stearoyl-CoA 9-desaturase NADPH oxidoreductase" }, { "name":"MSIM_22020 oxidoreductase\tK22770 K22770; stearoyl-CoA 9-desaturase NADPH oxidoreductase" }, { "name":"MSIM_40120 stearoyl-CoA 9-desaturase\tK22770 K22770; stearoyl-CoA 9-desaturase NADPH oxidoreductase" }, { "name":"MSIM_43200 acyl-CoA oxidase\tK00232 ACOX1_3; acyl-CoA oxidase [EC:1.3.3.6]" }, { "name":"MSIM_00800 tesB1; acyl-CoA thioesterase II\tK10805 tesB; acyl-CoA thioesterase II [EC:3.1.2.20]" }, { "name":"MSIM_04080 tesB2; acyl-CoA thioesterase II\tK10805 tesB; acyl-CoA thioesterase II [EC:3.1.2.20]" } ] } ] }, { "name":"09104 Nucleotide metabolism", "children":[ { "name":"00230 Purine metabolism [PATH:msim00230]", "children":[ { "name":"MSIM_09910 pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific\tK01835 pgm; phosphoglucomutase [EC:5.4.2.2]" }, { "name":"MSIM_36670 prs; ribose-phosphate pyrophosphokinase\tK00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]" }, { "name":"MSIM_30870 purF; amidophosphoribosyltransferase\tK00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]" }, { "name":"MSIM_30400 purD; phosphoribosylamine--glycine ligase\tK01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13]" }, { "name":"MSIM_34790 purN; phosphoribosylglycinamide formyltransferase\tK11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]" }, { "name":"MSIM_18800 purT; phosphoribosylglycinamide formyltransferase 2\tK08289 purT; phosphoribosylglycinamide formyltransferase 2 [EC:6.3.1.21]" }, { "name":"MSIM_30840 purL; phosphoribosylformylglycinamidine synthase subunit PurL\tK23269 purL; phosphoribosylformylglycinamidine synthase subunit PurL [EC:6.3.5.3]" }, { "name":"MSIM_30580 purS; phosphoribosylformylglycinamidine synthase subunit PurS\tK23264 purS; phosphoribosylformylglycinamidine synthase subunit PurS [EC:6.3.5.3]" }, { "name":"MSIM_30590 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ\tK23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ \/ glutaminase [EC:6.3.5.3 3.5.1.2]" }, { "name":"MSIM_30880 purM; phosphoribosylformylglycinamidine cyclo-ligase\tK01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]" }, { "name":"MSIM_13540 purK; N5-carboxyaminoimidazole ribonucleotide synthase\tK01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]" }, { "name":"MSIM_13530 purE; N5-carboxyaminoimidazole ribonucleotide mutase\tK01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]" }, { "name":"MSIM_30480 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase\tK01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]" }, { "name":"MSIM_30450 purB; adenylosuccinate lyase\tK01756 purB; adenylosuccinate lyase [EC:4.3.2.2]" }, { "name":"MSIM_34800 purH; bifunctional purine biosynthesis protein PurH\tK00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase \/ IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]" }, { "name":"MSIM_03860 apt; adenine phosphoribosyltransferase\tK00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]" }, { "name":"MSIM_13850 punA; purine nucleoside phosphorylase\tK03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]" }, { "name":"MSIM_46360 laccase domain protein\tK05810 LACC1; purine-nucleoside\/S-methyl-5'-thioadenosine phosphorylase \/ adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4]" }, { "name":"MSIM_14490 nucleoside hydrolase\tK01239 E3.2.2.1; purine nucleosidase [EC:3.2.2.1]" }, { "name":"MSIM_28400 hpt; hypoxanthine-guanine phosphoribosyltransferase\tK00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]" }, { "name":"MSIM_14620 guaB3; putative oxidoreductase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]" }, { "name":"MSIM_14630 guaB; inosine-5'-monophosphate dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]" }, { "name":"MSIM_41810 ndkA; nucleoside diphosphate kinase\tK00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]" }, { "name":"MSIM_40050 rdgB; non-canonical purine NTP pyrophosphatase\tK01519 rdgB; XTP\/dITP diphosphohydrolase [EC:3.6.1.66]" }, { "name":"MSIM_14540 guaA; GMP synthase [glutamine-hydrolyzing]\tK01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]" }, { "name":"MSIM_51690 guaB1; putative oxidoreductase\tK26110 guaB1; GMP reductase [EC:1.7.1.7]" }, { "name":"MSIM_19550 putative amidohydrolase\tK01487 guaD; guanine deaminase [EC:3.5.4.3]" }, { "name":"MSIM_02890 gmk; guanylate kinase\tK00942 gmk; guanylate kinase [EC:2.7.4.8]" }, { "name":"MSIM_09280 nrdE; ribonucleoside-diphosphate reductase subunit alpha\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]" }, { "name":"MSIM_08910 nrdF; ribonucleoside-diphosphate reductase subunit beta\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]" }, { "name":"MSIM_20410 nrdB; R2-like ligand binding oxidase\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]" }, { "name":"MSIM_42940 dgt; deoxyguanosinetriphosphate triphosphohydrolase-like protein\tK01129 dgt; dGTPase [EC:3.1.5.1]" }, { "name":"MSIM_03850 relA; putative GTP pyrophosphokinase\tK01139 spoT; GTP diphosphokinase \/ guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]" }, { "name":"MSIM_17570 hypothetical protein\tK01524 ppx-gppA; exopolyphosphatase \/ guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]" }, { "name":"MSIM_36790 hypothetical protein\tK01524 ppx-gppA; exopolyphosphatase \/ guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]" }, { "name":"MSIM_00730 cya; adenylate cyclase\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_14810 hypothetical protein\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_16720 cyaO; guanylate cyclase\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_19630 cyclase\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_28270 adenylate\/guanylate cyclase domain-containing protein\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_37320 adenylate\/guanylate cyclase domain-containing protein\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_39100 pH-sensitive adenylate cyclase\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_50980 hypothetical protein\tK01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1]" }, { "name":"MSIM_18820 purA; adenylosuccinate synthetase\tK01939 purA; adenylosuccinate synthase [EC:6.3.4.4]" }, { "name":"MSIM_45820 adoK; adenosine kinase\tK00856 ADK; adenosine kinase [EC:2.7.1.20]" }, { "name":"MSIM_13970 add; adenosine deaminase\tK01488 add; adenosine deaminase [EC:3.5.4.4]" }, { "name":"MSIM_10270 ymdB; hypothetical protein\tK09769 ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16]" }, { "name":"MSIM_15540 adk; adenylate kinase\tK00939 adk; adenylate kinase [EC:2.7.4.3]" }, { "name":"MSIM_36730 nucleoside triphosphate pyrophosphohydrolase\tK04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]" }, { "name":"MSIM_04180 AP-4-A phosphorylase\tK19710 E2.7.7.53; ATP adenylyltransferase [EC:2.7.7.53]" }, { "name":"MSIM_38360 adenylyl-sulfate kinase\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_39440 cysNC; bifunctional enzyme CysN\/CysC\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_38370 sulfate adenylyltransferase\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_39430 cysD; sulfate adenylyltransferase subunit 2\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_51620 ureC; urease subunit alpha\tK01428 ureC; urease subunit alpha [EC:3.5.1.5]" }, { "name":"MSIM_51630 ureB; urease subunit beta\tK01429 ureB; urease subunit beta [EC:3.5.1.5]" }, { "name":"MSIM_51640 ureA; urease subunit gamma\tK01430 ureA; urease subunit gamma [EC:3.5.1.5]" } ] }, { "name":"00240 Pyrimidine metabolism [PATH:msim00240]", "children":[ { "name":"MSIM_02920 carB; carbamoyl-phosphate synthase large chain\tK01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]" }, { "name":"MSIM_02930 carA; carbamoyl-phosphate synthase small chain\tK01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]" }, { "name":"MSIM_02960 pyrB; aspartate carbamoyltransferase\tK00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]" }, { "name":"MSIM_02950 pyrC; dihydroorotase\tK01465 URA4; dihydroorotase [EC:3.5.2.3]" }, { "name":"MSIM_46780 pyrD; dihydroorotate dehydrogenase (quinone)\tK00254 DHODH; dihydroorotate dehydrogenase [EC:1.3.5.2]" }, { "name":"MSIM_19080 pyrE; orotate phosphoribosyltransferase\tK00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]" }, { "name":"MSIM_02910 pyrF; orotidine 5'-phosphate decarboxylase\tK01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]" }, { "name":"MSIM_06860 pyrH; uridylate kinase\tK09903 pyrH; uridylate kinase [EC:2.7.4.22]" }, { "name":"MSIM_41810 ndkA; nucleoside diphosphate kinase\tK00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]" }, { "name":"MSIM_36730 nucleoside triphosphate pyrophosphohydrolase\tK04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]" }, { "name":"MSIM_13610 Maf-like protein\tK06287 yhdE; nucleoside triphosphate pyrophosphatase [EC:3.6.1.-]" }, { "name":"MSIM_54030 pyrG; CTP synthase\tK01937 pyrG; CTP synthase [EC:6.3.4.2]" }, { "name":"MSIM_53950 cmk; cytidylate kinase\tK00945 cmk; CMP\/dCMP kinase [EC:2.7.4.25]" }, { "name":"MSIM_13870 upp; uracil phosphoribosyltransferase\tK00761 upp; uracil phosphoribosyltransferase [EC:2.4.2.9]" }, { "name":"MSIM_02970 pyrR; bifunctional protein PyrR\tK02825 pyrR; pyrimidine operon attenuation protein \/ uracil phosphoribosyltransferase [EC:2.4.2.9]" }, { "name":"MSIM_10270 ymdB; hypothetical protein\tK09769 ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16]" }, { "name":"MSIM_13990 cdd; cytidine deaminase\tK01489 cdd; cytidine deaminase [EC:3.5.4.5]" }, { "name":"MSIM_19420 dcd; dCTP deaminase\tK01494 dcd; dCTP deaminase [EC:3.5.4.13]" }, { "name":"MSIM_09280 nrdE; ribonucleoside-diphosphate reductase subunit alpha\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]" }, { "name":"MSIM_08910 nrdF; ribonucleoside-diphosphate reductase subunit beta\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]" }, { "name":"MSIM_20410 nrdB; R2-like ligand binding oxidase\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]" }, { "name":"MSIM_12930 tmk; thymidylate kinase\tK00943 tmk; dTMP kinase [EC:2.7.4.9]" }, { "name":"MSIM_04940 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]" }, { "name":"MSIM_13980 deoA; thymidine phosphorylase\tK00758 deoA; thymidine phosphorylase [EC:2.4.2.4]" }, { "name":"MSIM_05520 thyA; thymidylate synthase\tK00560 thyA; thymidylate synthase [EC:2.1.1.45]" }, { "name":"MSIM_05460 thyX; flavin-dependent thymidylate synthase\tK03465 thyX; thymidylate synthase (FAD) [EC:2.1.1.148]" }, { "name":"MSIM_30070 putative hydrolase\tK06016 pydC; beta-ureidopropionase \/ N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87]" } ] } ] }, { "name":"09105 Amino acid metabolism", "children":[ { "name":"00250 Alanine, aspartate and glutamate metabolism [PATH:msim00250]", "children":[ { "name":"MSIM_01040 nadB; L-aspartate oxidase\tK00278 nadB; L-aspartate oxidase [EC:1.4.3.16]" }, { "name":"MSIM_01440 ansA; putative L-asparaginase\tK01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1]" }, { "name":"MSIM_44110 asnB_1; asparagine synthetase B\tK01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]" }, { "name":"MSIM_45830 asnB_2; putative asparagine synthetase [glutamine-hydrolyzing]\tK01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]" }, { "name":"MSIM_19330 aspC; putative aspartate aminotransferase\tK14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]" }, { "name":"MSIM_05850 ald; alanine dehydrogenase\tK00259 ald; alanine dehydrogenase [EC:1.4.1.1]" }, { "name":"MSIM_00220 argG; argininosuccinate synthase\tK01940 argG; argininosuccinate synthase [EC:6.3.4.5]" }, { "name":"MSIM_00210 argH; argininosuccinate lyase\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]" }, { "name":"MSIM_18820 purA; adenylosuccinate synthetase\tK01939 purA; adenylosuccinate synthase [EC:6.3.4.4]" }, { "name":"MSIM_30450 purB; adenylosuccinate lyase\tK01756 purB; adenylosuccinate lyase [EC:4.3.2.2]" }, { "name":"MSIM_02960 pyrB; aspartate carbamoyltransferase\tK00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]" }, { "name":"MSIM_14910 gadB; glutamate decarboxylase\tK01580 E4.1.1.15; glutamate decarboxylase [EC:4.1.1.15]" }, { "name":"MSIM_03910 gabT; 4-aminobutyrate aminotransferase\tK07250 gabT; 4-aminobutyrate aminotransferase \/ (S)-3-amino-2-methylpropionate transaminase \/ 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]" }, { "name":"MSIM_20400 gabD1; succinate-semialdehyde dehydrogenase [NADP(+)] 1\tK00135 gabD; succinate-semialdehyde dehydrogenase \/ glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]" }, { "name":"MSIM_25450 gltB; glutamate synthase\tK00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]" }, { "name":"MSIM_25460 gltD; glutamate synthase [NADPH] small chain\tK00266 gltD; glutamate synthase (NADPH) small chain [EC:1.4.1.13]" }, { "name":"MSIM_41520 gdh; NAD-glutamate dehydrogenase\tK15371 GDH2; glutamate dehydrogenase [EC:1.4.1.2]" }, { "name":"MSIM_38400 rocA; pyrroline-5-carboxylate dehydrogenase RocA\tK00294 E1.2.1.88; 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]" }, { "name":"MSIM_28420 glnT; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45490 glnA2; putative glutamine synthetase 2\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45600 glnA1; glutamine synthetase 1\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51050 glnA3; glutamine synthetase GlnA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51550 type III glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_53180 glnN; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_02920 carB; carbamoyl-phosphate synthase large chain\tK01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]" }, { "name":"MSIM_02930 carA; carbamoyl-phosphate synthase small chain\tK01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]" }, { "name":"MSIM_30590 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ\tK23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ \/ glutaminase [EC:6.3.5.3 3.5.1.2]" }, { "name":"MSIM_14990 glmS; glutamine--fructose-6-phosphate aminotransferase [isomerizing]\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]" }, { "name":"MSIM_33470 hypothetical protein\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]" }, { "name":"MSIM_30870 purF; amidophosphoribosyltransferase\tK00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]" } ] }, { "name":"00260 Glycine, serine and threonine metabolism [PATH:msim00260]", "children":[ { "name":"MSIM_27380 ask; aspartokinase\tK00928 lysC; aspartate kinase [EC:2.7.2.4]" }, { "name":"MSIM_27390 asd; aspartate-semialdehyde dehydrogenase\tK00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]" }, { "name":"MSIM_39610 hom; homoserine dehydrogenase\tK00003 hom; homoserine dehydrogenase [EC:1.1.1.3]" }, { "name":"MSIM_39630 thrB; homoserine kinase\tK00872 thrB; homoserine kinase [EC:2.7.1.39]" }, { "name":"MSIM_39620 thrC; threonine synthase\tK01733 thrC; threonine synthase [EC:4.2.3.1]" }, { "name":"MSIM_37280 glyA1; serine hydroxymethyltransferase 1\tK00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]" }, { "name":"MSIM_06080 glxK; glycerate kinase\tK00865 glxK; glycerate 2-kinase [EC:2.7.1.165]" }, { "name":"MSIM_45790 hypothetical protein\tK00865 glxK; glycerate 2-kinase [EC:2.7.1.165]" }, { "name":"MSIM_17650 gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]" }, { "name":"MSIM_08260 serA; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_15610 serA2; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_35770 D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_33010 serC; putative phosphoserine aminotransferase\tK00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]" }, { "name":"MSIM_08850 phosphoserine phosphatase SerB\tK01079 serB; phosphoserine phosphatase [EC:3.1.3.3]" }, { "name":"MSIM_11190 aofH; putative flavin-containing monoamine oxidase AofH\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_37680 monoamine oxidase\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_51750 gcvP; putative glycine dehydrogenase (decarboxylating)\tK00281 GLDC; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]" }, { "name":"MSIM_45730 gcvT; aminomethyltransferase\tK00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_46520 gcvH_1; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" }, { "name":"MSIM_51810 gcvH_2; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" }, { "name":"MSIM_40750 aao_1; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_50640 aao_2; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_18200 pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase\tK17103 CHO1; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]" }, { "name":"MSIM_19210 betB; NAD\/NADP-dependent betaine aldehyde dehydrogenase\tK00130 betB; betaine-aldehyde dehydrogenase [EC:1.2.1.8]" }, { "name":"MSIM_14570 SAM-dependent methyltransferase\tK18897 sdmt; sarcosine\/dimethylglycine N-methyltransferase [EC:2.1.1.157]" }, { "name":"MSIM_37120 cbs; cystathionine beta-synthase\tK01697 CBS; cystathionine beta-synthase [EC:4.2.1.22]" }, { "name":"MSIM_01300 ilvA; L-threonine dehydratase biosynthetic IlvA\tK01754 E4.3.1.19; threonine dehydratase [EC:4.3.1.19]" }, { "name":"MSIM_00850 trpA; tryptophan synthase alpha chain\tK01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20]" }, { "name":"MSIM_00860 trpB_1; tryptophan synthase beta chain\tK01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20]" }, { "name":"MSIM_37780 trpB_2; tryptophan synthase beta chain\tK06001 trpB; tryptophan synthase beta chain [EC:4.2.1.20]" } ] }, { "name":"00270 Cysteine and methionine metabolism [PATH:msim00270]", "children":[ { "name":"MSIM_42980 cysE; serine acetyltransferase\tK00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]" }, { "name":"MSIM_42990 cysK; O-acetylserine sulfhydrylase\tK01738 cysK; cysteine synthase [EC:2.5.1.47]" }, { "name":"MSIM_44450 putative cystathionine beta-lyase\tK14155 patB; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]" }, { "name":"MSIM_37120 cbs; cystathionine beta-synthase\tK01697 CBS; cystathionine beta-synthase [EC:4.2.1.22]" }, { "name":"MSIM_41700 mmuM; homocysteine S-methyltransferase\tK00547 mmuM; homocysteine S-methyltransferase [EC:2.1.1.10]" }, { "name":"MSIM_46910 5-methyltetrahydrofolate--homocysteine methyltransferase MetH\tK00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]" }, { "name":"MSIM_37750 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase\tK00549 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]" }, { "name":"MSIM_02860 metK; S-adenosylmethionine synthase\tK00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]" }, { "name":"MSIM_04020 speE; polyamine aminopropyltransferase\tK00797 speE; spermidine synthase [EC:2.5.1.16]" }, { "name":"MSIM_22640 mtnN; 5'-methylthioadenosine\/S-adenosylhomocysteine nucleosidase\tK01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9]" }, { "name":"MSIM_17140 mtnP; S-methyl-5'-thioadenosine phosphorylase\tK00772 mtaP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]" }, { "name":"MSIM_46360 laccase domain protein\tK05810 LACC1; purine-nucleoside\/S-methyl-5'-thioadenosine phosphorylase \/ adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4]" }, { "name":"MSIM_12940 ahcY; adenosylhomocysteinase\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]" }, { "name":"MSIM_27380 ask; aspartokinase\tK00928 lysC; aspartate kinase [EC:2.7.2.4]" }, { "name":"MSIM_27390 asd; aspartate-semialdehyde dehydrogenase\tK00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]" }, { "name":"MSIM_39610 hom; homoserine dehydrogenase\tK00003 hom; homoserine dehydrogenase [EC:1.1.1.3]" }, { "name":"MSIM_39630 thrB; homoserine kinase\tK00872 thrB; homoserine kinase [EC:2.7.1.39]" }, { "name":"MSIM_14190 metX; homoserine O-acetyltransferase\tK00641 metX; homoserine O-acetyltransferase\/O-succinyltransferase [EC:2.3.1.31 2.3.1.46]" }, { "name":"MSIM_39570 homoserine O-acetyltransferase\tK00641 metX; homoserine O-acetyltransferase\/O-succinyltransferase [EC:2.3.1.31 2.3.1.46]" }, { "name":"MSIM_37140 metB; cystathionine gamma-synthase\tK01739 metB; cystathionine gamma-synthase [EC:2.5.1.48]" }, { "name":"MSIM_14180 metC; bifunctional o-acetylhomoserine\/o-acetylserine sulfhydrylase\tK01740 metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]" }, { "name":"MSIM_18780 metZ; O-succinylhomoserine sulfhydrylase\tK10764 metZ; O-succinylhomoserine sulfhydrylase [EC:2.5.1.-]" }, { "name":"MSIM_45740 ilvE; branched-chain-amino-acid aminotransferase\tK00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]" }, { "name":"MSIM_27460 egtA; glutamate--cysteine ligase EgtA\tK01919 gshA; glutamate---cysteine ligase [EC:6.3.2.2]" }, { "name":"MSIM_13620 sseA; putative thiosulfate sulfurtransferase SseA\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_30960 cysA2; thiosulfate sulfurtransferase CysA\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_44610 sseB; putative thiosulfate sulfurtransferase SseB\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_27860 cysteine synthase\tK28981 cds1; L-cysteine desulfidase [EC:4.4.1.28]" }, { "name":"MSIM_38850 mdh; malate dehydrogenase\tK00024 mdh; malate dehydrogenase [EC:1.1.1.37]" }, { "name":"MSIM_08260 serA; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_15610 serA2; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_35770 D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_33010 serC; putative phosphoserine aminotransferase\tK00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]" } ] }, { "name":"00280 Valine, leucine and isoleucine degradation [PATH:msim00280]", "children":[ { "name":"MSIM_45740 ilvE; branched-chain-amino-acid aminotransferase\tK00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]" }, { "name":"MSIM_34130 bkdA; 2-oxoisovalerate dehydrogenase E1\tK11381 bkdA; 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_09570 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_10820 fadE23; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_10910 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_20430 fadE4; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_21710 fadE2; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_22060 fadE1; acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_23390 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_24700 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_26430 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_31940 acyl-CoA dehydrogenase\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_34890 fadE13; acyl-CoA dehydrogenase FadE13\tK00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7]" }, { "name":"MSIM_41300 fadE19; acyl-CoA dehydrogenase\tK11410 acdH; short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_05960 ltp1; lipid-transfer protein\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_12520 acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29240 fadA6; acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29330 fadA5; steroid 3-ketoacyl-CoA thiolase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_31960 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_37930 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_13640 acetyl-\/propionyl-CoA carboxylase subunit alpha\tK11263 bccA; acetyl-CoA\/propionyl-CoA\/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]" }, { "name":"MSIM_13590 accD5; putative propionyl-CoA carboxylase beta chain 5\tK27094 accD5; propionyl-CoA\/long-chain acyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.3 6.4.1.- 2.1.3.15]" }, { "name":"MSIM_13600 hypothetical protein\tK27095 accE5; acyl-CoA carboxylase epsilon subunit" }, { "name":"MSIM_45140 accD6; putative propionyl-CoA carboxylase beta chain 6\tK18472 accD6; acetyl-CoA\/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]" }, { "name":"MSIM_39880 methylmalonyl-CoA epimerase\tK05606 MCEE; methylmalonyl-CoA\/ethylmalonyl-CoA epimerase [EC:5.1.99.1]" }, { "name":"MSIM_01870 mutB; putative methylmalonyl-CoA mutase large subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_01880 mutA; putative methylmalonyl-CoA mutase small subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_31330 methylmalonyl-CoA mutase\tK01849 E5.4.99.2B; methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_31320 methylmalonyl-CoA mutase\tK01848 E5.4.99.2A; methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2]" }, { "name":"MSIM_15450 mmsB; putative 3-hydroxyisobutyrate dehydrogenase\tK00020 HIBADH; 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]" }, { "name":"MSIM_15430 mmsA; methylmalonate-semialdehyde dehydrogenase (acylating)\tK00140 mmsA; malonate-semialdehyde dehydrogenase (acetylating) \/ methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_03910 gabT; 4-aminobutyrate aminotransferase\tK07250 gabT; 4-aminobutyrate aminotransferase \/ (S)-3-amino-2-methylpropionate transaminase \/ 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]" }, { "name":"MSIM_41290 accA1; acetyl-\/propionyl-coenzyme A carboxylase alpha chain\tK01968 MCCC1; 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4]" }, { "name":"MSIM_41280 accD1; acetyl-\/propionyl-CoA carboxylase subunit beta\tK01969 MCCC2; 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4]" }, { "name":"MSIM_07070 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_10890 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_18900 succinyl-CoA--3-ketoacid-CoA transferase\tK01027 OXCT; 3-oxoacid CoA-transferase [EC:2.8.3.5]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" } ] }, { "name":"00290 Valine, leucine and isoleucine biosynthesis [PATH:msim00290]", "children":[ { "name":"MSIM_01300 ilvA; L-threonine dehydratase biosynthetic IlvA\tK01754 E4.3.1.19; threonine dehydratase [EC:4.3.1.19]" }, { "name":"MSIM_08190 leuC; 3-isopropylmalate dehydratase large subunit\tK01703 leuC; 3-isopropylmalate\/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]" }, { "name":"MSIM_08180 leuD; 3-isopropylmalate dehydratase small subunit\tK01704 leuD; 3-isopropylmalate\/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]" }, { "name":"MSIM_08250 leuB; 3-isopropylmalate dehydrogenase\tK00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]" }, { "name":"MSIM_08320 ilvB1; acetolactate synthase large subunit IlvB1\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_15500 acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_20390 putative acetolactate synthase large subunit IlvB\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_22300 acetolactate synthase large subunit\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_29640 ilvX; putative acetolactate synthase large subunit IlvX\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_44650 alsS; acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_08310 ilvH; putative acetolactate synthase small subunit\tK01653 E2.2.1.6S; acetolactate synthase I\/III small subunit [EC:2.2.1.6]" }, { "name":"MSIM_08300 ilvC; ketol-acid reductoisomerase (NADP(+))\tK00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]" }, { "name":"MSIM_21020 ilvD; dihydroxy-acid dehydratase\tK01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]" }, { "name":"MSIM_45740 ilvE; branched-chain-amino-acid aminotransferase\tK00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]" }, { "name":"MSIM_19330 aspC; putative aspartate aminotransferase\tK14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]" }, { "name":"MSIM_27370 leuA; 2-isopropylmalate synthase\tK01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]" } ] }, { "name":"00300 Lysine biosynthesis [PATH:msim00300]", "children":[ { "name":"MSIM_39610 hom; homoserine dehydrogenase\tK00003 hom; homoserine dehydrogenase [EC:1.1.1.3]" }, { "name":"MSIM_27380 ask; aspartokinase\tK00928 lysC; aspartate kinase [EC:2.7.2.4]" }, { "name":"MSIM_27390 asd; aspartate-semialdehyde dehydrogenase\tK00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]" }, { "name":"MSIM_03510 putative dihydrodipicolinate synthetase DapA\tK01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]" }, { "name":"MSIM_05450 dapA; 4-hydroxy-tetrahydrodipicolinate synthase\tK01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]" }, { "name":"MSIM_40380 hypothetical protein\tK01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]" }, { "name":"MSIM_05710 dapB_1; 4-hydroxy-tetrahydrodipicolinate reductase\tK00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]" }, { "name":"MSIM_05760 dapB_2; dihydrodipicolinate reductase\tK00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]" }, { "name":"MSIM_38520 dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase\tK00674 dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]" }, { "name":"MSIM_00250 argD; acetylornithine aminotransferase\tK00821 argD; acetylornithine\/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]" }, { "name":"MSIM_32630 N-succinyldiaminopimelate aminotransferase DapC\tK14267 dapC; N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17]" }, { "name":"MSIM_38530 dapE; succinyl-diaminopimelate desuccinylase\tK01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]" }, { "name":"MSIM_05220 dapF; diaminopimelate epimerase\tK01778 dapF; diaminopimelate epimerase [EC:5.1.1.7]" }, { "name":"MSIM_26930 lysA_1; diaminopimelate decarboxylase\tK01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]" }, { "name":"MSIM_36710 lysA_2; diaminopimelate decarboxylase\tK01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]" }, { "name":"MSIM_39600 lysA_3; diaminopimelate decarboxylase\tK01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]" }, { "name":"MSIM_46270 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\tK01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]" }, { "name":"MSIM_46280 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase\tK01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]" } ] }, { "name":"00310 Lysine degradation [PATH:msim00310]", "children":[ { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_18720 fadE7; acyl-CoA dehydrogenase\tK00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_03910 gabT; 4-aminobutyrate aminotransferase\tK07250 gabT; 4-aminobutyrate aminotransferase \/ (S)-3-amino-2-methylpropionate transaminase \/ 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]" }, { "name":"MSIM_20400 gabD1; succinate-semialdehyde dehydrogenase [NADP(+)] 1\tK00135 gabD; succinate-semialdehyde dehydrogenase \/ glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" } ] }, { "name":"00220 Arginine biosynthesis [PATH:msim00220]", "children":[ { "name":"MSIM_00240 argF; ornithine carbamoyltransferase\tK00611 OTC; ornithine carbamoyltransferase [EC:2.1.3.3]" }, { "name":"MSIM_00220 argG; argininosuccinate synthase\tK01940 argG; argininosuccinate synthase [EC:6.3.4.5]" }, { "name":"MSIM_00210 argH; argininosuccinate lyase\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]" }, { "name":"MSIM_43300 hypothetical protein\tK27545 argZ; arginine dihydrolase [EC:3.5.3.27]" }, { "name":"MSIM_51620 ureC; urease subunit alpha\tK01428 ureC; urease subunit alpha [EC:3.5.1.5]" }, { "name":"MSIM_51630 ureB; urease subunit beta\tK01429 ureB; urease subunit beta [EC:3.5.1.5]" }, { "name":"MSIM_51640 ureA; urease subunit gamma\tK01430 ureA; urease subunit gamma [EC:3.5.1.5]" }, { "name":"MSIM_36110 arcA; arginine deiminase\tK01478 arcA; arginine deiminase [EC:3.5.3.6]" }, { "name":"MSIM_30590 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ\tK23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ \/ glutaminase [EC:6.3.5.3 3.5.1.2]" }, { "name":"MSIM_28420 glnT; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45490 glnA2; putative glutamine synthetase 2\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45600 glnA1; glutamine synthetase 1\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51050 glnA3; glutamine synthetase GlnA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51550 type III glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_53180 glnN; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_02920 carB; carbamoyl-phosphate synthase large chain\tK01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]" }, { "name":"MSIM_02930 carA; carbamoyl-phosphate synthase small chain\tK01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]" }, { "name":"MSIM_41520 gdh; NAD-glutamate dehydrogenase\tK15371 GDH2; glutamate dehydrogenase [EC:1.4.1.2]" }, { "name":"MSIM_19330 aspC; putative aspartate aminotransferase\tK14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]" }, { "name":"MSIM_05390 N-acetylglutamate synthase\tK00619 argA; amino-acid N-acetyltransferase [EC:2.3.1.1]" }, { "name":"MSIM_00270 argJ; arginine biosynthesis bifunctional protein ArgJ\tK00620 argJ; glutamate N-acetyltransferase \/ amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1]" }, { "name":"MSIM_18330 hypothetical protein\tK22476 K22476; N-acetylglutamate synthase [EC:2.3.1.1]" }, { "name":"MSIM_00260 argB; acetylglutamate kinase\tK00930 argB; acetylglutamate kinase [EC:2.7.2.8]" }, { "name":"MSIM_00280 argC; N-acetyl-gamma-glutamyl-phosphate reductase\tK00145 argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]" }, { "name":"MSIM_00250 argD; acetylornithine aminotransferase\tK00821 argD; acetylornithine\/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]" } ] }, { "name":"00330 Arginine and proline metabolism [PATH:msim00330]", "children":[ { "name":"MSIM_11720 putative Orn\/Lys\/Arg decarboxylase\tK01585 speA; arginine decarboxylase [EC:4.1.1.19]" }, { "name":"MSIM_51600 agmatinase\tK01480 speB; agmatinase [EC:3.5.3.11]" }, { "name":"MSIM_25870 hypothetical protein\tK01581 E4.1.1.17; ornithine decarboxylase [EC:4.1.1.17]" }, { "name":"MSIM_04020 speE; polyamine aminopropyltransferase\tK00797 speE; spermidine synthase [EC:2.5.1.16]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_11190 aofH; putative flavin-containing monoamine oxidase AofH\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_37680 monoamine oxidase\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_06940 amiC; putative amidase AmiC\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_39080 amiB2; putative amidase AmiB2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_42810 amiA2; putative amidase AmiA2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_43300 hypothetical protein\tK27545 argZ; arginine dihydrolase [EC:3.5.3.27]" }, { "name":"MSIM_43310 rocD; ornithine--oxo-acid transaminase\tK00819 rocD; ornithine--oxo-acid transaminase [EC:2.6.1.13]" }, { "name":"MSIM_17530 proC; pyrroline-5-carboxylate reductase\tK00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]" }, { "name":"MSIM_38410 proline dehydrogenase\tK00318 PRODH; proline dehydrogenase [EC:1.5.5.2]" }, { "name":"MSIM_38400 rocA; pyrroline-5-carboxylate dehydrogenase RocA\tK00294 E1.2.1.88; 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]" }, { "name":"MSIM_41860 proB; glutamate 5-kinase\tK00931 proB; glutamate 5-kinase [EC:2.7.2.11]" }, { "name":"MSIM_42020 proA; gamma-glutamyl phosphate reductase\tK00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]" }, { "name":"MSIM_31440 pip; proline iminopeptidase\tK01259 pip; proline iminopeptidase [EC:3.4.11.5]" }, { "name":"MSIM_40750 aao_1; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_50640 aao_2; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" } ] }, { "name":"00340 Histidine metabolism [PATH:msim00340]", "children":[ { "name":"MSIM_47070 hisG; ATP phosphoribosyltransferase\tK00765 hisG; ATP phosphoribosyltransferase [EC:2.4.2.17]" }, { "name":"MSIM_47060 hisE; phosphoribosyl-ATP pyrophosphatase\tK01523 hisE; phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31]" }, { "name":"MSIM_00940 hisI; phosphoribosyl-AMP cyclohydrolase\tK01496 hisI; phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19]" }, { "name":"MSIM_00970 priA_1; phosphoribosyl isomerase A\tK24017 priA; phosphoribosyl isomerase A [EC:5.3.1.16 5.3.1.24]" }, { "name":"MSIM_00980 hisH; imidazole glycerol phosphate synthase subunit HisH\tK02501 hisH; imidazole glycerol-phosphate synthase subunit HisH [EC:4.3.2.10]" }, { "name":"MSIM_00950 hisF; imidazole glycerol phosphate synthase subunit HisF\tK02500 hisF; imidazole glycerol-phosphate synthase subunit HisF [EC:4.3.2.10]" }, { "name":"MSIM_00990 hisB; imidazoleglycerol-phosphate dehydratase\tK01693 hisB; imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]" }, { "name":"MSIM_01000 hisC; histidinol-phosphate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_15470 aspartate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_26310 pat; putative phenylalanine aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_45390 putative aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_10800 histidinol-phosphatase\tK05602 hisN; histidinol-phosphatase [EC:3.1.3.15]" }, { "name":"MSIM_01010 hisD; histidinol dehydrogenase\tK00013 hisD; histidinol dehydrogenase [EC:1.1.1.23]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_11190 aofH; putative flavin-containing monoamine oxidase AofH\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_37680 monoamine oxidase\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_27490 egtD; histidine N-alpha-methyltransferase\tK18911 egtD; L-histidine Nalpha-methyltransferase [EC:2.1.1.44]" }, { "name":"MSIM_27460 egtA; glutamate--cysteine ligase EgtA\tK01919 gshA; glutamate---cysteine ligase [EC:6.3.2.2]" }, { "name":"MSIM_27470 egtB; hercynine oxygenase\tK18912 egtB; gamma-glutamyl hercynylcysteine S-oxide synthase [EC:1.14.99.50]" }, { "name":"MSIM_27480 egtC; gamma-glutamyl-hercynylcysteine sulfoxide hydrolase\tK07008 egtC; gamma-glutamyl hercynylcysteine S-oxide hydrolase [EC:3.5.1.118]" }, { "name":"MSIM_27500 egtE; putative hercynylcysteine sulfoxide lyase\tK18913 egtE; hercynylcysteine S-oxide lyase [EC:4.4.1.36]" } ] }, { "name":"00350 Tyrosine metabolism [PATH:msim00350]", "children":[ { "name":"MSIM_01000 hisC; histidinol-phosphate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_15470 aspartate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_26310 pat; putative phenylalanine aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_45390 putative aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_10860 hmgA; hypothetical protein\tK00451 HGD; homogentisate 1,2-dioxygenase [EC:1.13.11.5]" }, { "name":"MSIM_54000 methyltransferase\tK00545 COMT; catechol O-methyltransferase [EC:2.1.1.6]" }, { "name":"MSIM_11190 aofH; putative flavin-containing monoamine oxidase AofH\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_37680 monoamine oxidase\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_43950 aldehyde dehydrogenase\tK00146 feaB; phenylacetaldehyde dehydrogenase [EC:1.2.1.39]" }, { "name":"MSIM_30180 adhB; alcohol dehydrogenase B\tK00121 frmA; S-(hydroxymethyl)glutathione dehydrogenase \/ alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]" }, { "name":"MSIM_09660 alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_51380 adhA; alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_36600 hypothetical protein\tK00483 hpaB; 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]" }, { "name":"MSIM_21390 aldolase\tK02510 hpaI; 4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52]" }, { "name":"MSIM_35750 aldolase\tK02510 hpaI; 4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52]" }, { "name":"MSIM_20400 gabD1; succinate-semialdehyde dehydrogenase [NADP(+)] 1\tK00135 gabD; succinate-semialdehyde dehydrogenase \/ glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]" } ] }, { "name":"00360 Phenylalanine metabolism [PATH:msim00360]", "children":[ { "name":"MSIM_11190 aofH; putative flavin-containing monoamine oxidase AofH\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_37680 monoamine oxidase\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_43950 aldehyde dehydrogenase\tK00146 feaB; phenylacetaldehyde dehydrogenase [EC:1.2.1.39]" }, { "name":"MSIM_34050 paaG_4; enoyl-CoA hydratase\tK15866 paaG; 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]" }, { "name":"MSIM_35680 enoyl-CoA hydratase\tK15866 paaG; 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]" }, { "name":"MSIM_35700 enoyl-CoA hydratase\tK15866 paaG; 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]" }, { "name":"MSIM_40340 enoyl-CoA hydratase\tK15866 paaG; 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_12460 putative dehydrogenase (3-hydroxybutyryl-CoA dehydrogenase FadB?)\tK00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]" }, { "name":"MSIM_17830 fadB2; 3-hydroxybutyryl-CoA dehydrogenase\tK00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]" }, { "name":"MSIM_01000 hisC; histidinol-phosphate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_15470 aspartate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_26310 pat; putative phenylalanine aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_45390 putative aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_49980 katG2; catalase-peroxidase 2\tK03782 katG; catalase-peroxidase [EC:1.11.1.21]" }, { "name":"MSIM_06940 amiC; putative amidase AmiC\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_39080 amiB2; putative amidase AmiB2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_42810 amiA2; putative amidase AmiA2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_51260 reductase\tK00529 hcaD; 3-phenylpropionate\/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]" }, { "name":"MSIM_31520 mhpA_1; 3-(3-hydroxy-phenyl)propionate\/3-hydroxycinnamic acid hydroxylase\tK05712 mhpA; 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127]" }, { "name":"MSIM_49250 mhpA_2; 3-(3-hydroxyphenyl)propionate hydroxylase\tK05712 mhpA; 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127]" }, { "name":"MSIM_31530 mhpB; 2,3-dihydroxyphenylpropionate\/2, 3-dihydroxicinnam ic acid 1,2-dioxygenase\tK05713 mhpB; 2,3-dihydroxyphenylpropionate 1,2-dioxygenase [EC:1.13.11.16]" }, { "name":"MSIM_31510 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase\tK05714 mhpC; 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase [EC:3.7.1.14]" }, { "name":"MSIM_32110 alpha\/beta hydrolase\tK05714 mhpC; 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase [EC:3.7.1.14]" }, { "name":"MSIM_29430 hsaE; hydratase\tK02554 mhpD; 2-keto-4-pentenoate hydratase [EC:4.2.1.80]" }, { "name":"MSIM_29450 bphI-2; 4-hydroxy-2-oxovalerate aldolase 2\tK01666 mhpE; 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]" }, { "name":"MSIM_29440 mhpF; acetaldehyde dehydrogenase 2\tK04073 mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10]" } ] }, { "name":"00380 Tryptophan metabolism [PATH:msim00380]", "children":[ { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_18720 fadE7; acyl-CoA dehydrogenase\tK00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_11190 aofH; putative flavin-containing monoamine oxidase AofH\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_37680 monoamine oxidase\tK00274 MAO; monoamine oxidase [EC:1.4.3.4]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20980 nitrilase\tK01501 E3.5.5.1; nitrilase [EC:3.5.5.1]" }, { "name":"MSIM_46440 nthA; nitrile hydratase subunit alpha\tK01721 nthA; nitrile hydratase subunit alpha [EC:4.2.1.84]" }, { "name":"MSIM_46430 nitrile hydratase\tK20807 nthB; nitrile hydratase subunit beta [EC:4.2.1.84]" }, { "name":"MSIM_06940 amiC; putative amidase AmiC\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_39080 amiB2; putative amidase AmiB2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_42810 amiA2; putative amidase AmiA2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_04380 srpA; catalase-related peroxidase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_23170 catalase-related peroxidase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_27440 katA; catalase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_49980 katG2; catalase-peroxidase 2\tK03782 katG; catalase-peroxidase [EC:1.11.1.21]" } ] }, { "name":"00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:msim00400]", "children":[ { "name":"MSIM_46080 aroG; phospho-2-dehydro-3-deoxyheptonate aldolase\tK01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]" }, { "name":"MSIM_48710 aroF; phospho-2-dehydro-3-deoxyheptonate aldolase\tK01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]" }, { "name":"MSIM_03270 aroB; 3-dehydroquinate synthase\tK01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4]" }, { "name":"MSIM_03260 aroQ; 3-dehydroquinate dehydratase\tK03786 aroQ; 3-dehydroquinate dehydratase II [EC:4.2.1.10]" }, { "name":"MSIM_48620 4-hydroxyphenylpyruvate dioxygenase\tK26400 quiC1; 3-dehydroshikimate dehydratase [EC:4.2.1.118]" }, { "name":"MSIM_03280 aroK_1; shikimate kinase\tK00891 aroK; shikimate kinase [EC:2.7.1.71]" }, { "name":"MSIM_12490 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase\tK00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]" }, { "name":"MSIM_03290 aroC; chorismate synthase\tK01736 aroC; chorismate synthase [EC:4.2.3.5]" }, { "name":"MSIM_00890 trpE; anthranilate synthase component 1\tK01657 trpE; anthranilate synthase component I [EC:4.1.3.27]" }, { "name":"MSIM_00970 priA_1; phosphoribosyl isomerase A\tK24017 priA; phosphoribosyl isomerase A [EC:5.3.1.16 5.3.1.24]" }, { "name":"MSIM_00870 trpC; indole-3-glycerol phosphate synthase\tK01609 trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]" }, { "name":"MSIM_00850 trpA; tryptophan synthase alpha chain\tK01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20]" }, { "name":"MSIM_00860 trpB_1; tryptophan synthase beta chain\tK01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20]" }, { "name":"MSIM_37780 trpB_2; tryptophan synthase beta chain\tK06001 trpB; tryptophan synthase beta chain [EC:4.2.1.20]" }, { "name":"MSIM_23870 secreted chorismate mutase\tK04093 pheA1; chorismate mutase [EC:5.4.99.5]" }, { "name":"MSIM_34680 hypothetical protein\tK04093 pheA1; chorismate mutase [EC:5.4.99.5]" }, { "name":"MSIM_50870 secreted chorismate mutase\tK04093 pheA1; chorismate mutase [EC:5.4.99.5]" }, { "name":"MSIM_26550 tyrA; prephenate dehydrogenase\tK04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12]" }, { "name":"MSIM_23850 cyclohexadienyl dehydratase\tK01713 pheC; cyclohexadienyl dehydratase [EC:4.2.1.51 4.2.1.91]" }, { "name":"MSIM_25680 pheA; prephenate dehydratase\tK04518 pheA2; prephenate dehydratase [EC:4.2.1.51]" }, { "name":"MSIM_01000 hisC; histidinol-phosphate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_15470 aspartate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_26310 pat; putative phenylalanine aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_45390 putative aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" } ] } ] }, { "name":"09106 Metabolism of other amino acids", "children":[ { "name":"00410 beta-Alanine metabolism [PATH:msim00410]", "children":[ { "name":"MSIM_28670 panD; aspartate 1-decarboxylase\tK01579 panD; aspartate 1-decarboxylase [EC:4.1.1.11]" }, { "name":"MSIM_14910 gadB; glutamate decarboxylase\tK01580 E4.1.1.15; glutamate decarboxylase [EC:4.1.1.15]" }, { "name":"MSIM_03910 gabT; 4-aminobutyrate aminotransferase\tK07250 gabT; 4-aminobutyrate aminotransferase \/ (S)-3-amino-2-methylpropionate transaminase \/ 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_28660 panC; pantothenate synthetase\tK01918 panC; pantoate--beta-alanine ligase [EC:6.3.2.1]" }, { "name":"MSIM_30070 putative hydrolase\tK06016 pydC; beta-ureidopropionase \/ N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_43200 acyl-CoA oxidase\tK00232 ACOX1_3; acyl-CoA oxidase [EC:1.3.3.6]" }, { "name":"MSIM_15430 mmsA; methylmalonate-semialdehyde dehydrogenase (acylating)\tK00140 mmsA; malonate-semialdehyde dehydrogenase (acetylating) \/ methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]" } ] }, { "name":"00430 Taurine and hypotaurine metabolism [PATH:msim00430]", "children":[ { "name":"MSIM_14910 gadB; glutamate decarboxylase\tK01580 E4.1.1.15; glutamate decarboxylase [EC:4.1.1.15]" }, { "name":"MSIM_30410 ggtA; bifunctional cephalosporin acylase\/gamma-glutamyltranspeptidase\tK00681 ggt; gamma-glutamyltranspeptidase \/ glutathione hydrolase [EC:2.3.2.2 3.4.19.13]" }, { "name":"MSIM_05850 ald; alanine dehydrogenase\tK00259 ald; alanine dehydrogenase [EC:1.4.1.1]" }, { "name":"MSIM_41520 gdh; NAD-glutamate dehydrogenase\tK15371 GDH2; glutamate dehydrogenase [EC:1.4.1.2]" }, { "name":"MSIM_09110 sulfoacetaldehyde acetyltransferase\tK03852 xsc; sulfoacetaldehyde acetyltransferase [EC:2.3.3.15]" }, { "name":"MSIM_18620 pta; phosphate acetyltransferase\tK13788 pta; phosphate acetyltransferase [EC:2.3.1.8]" }, { "name":"MSIM_18610 ackA; acetate kinase\tK00925 ackA; acetate kinase [EC:2.7.2.1]" }, { "name":"MSIM_08960 hypothetical protein\tK15515 sauS; sulfoacetaldehyde dehydrogenase [EC:1.2.1.81]" } ] }, { "name":"00440 Phosphonate and phosphinate metabolism [PATH:msim00440]", "children":[ { "name":"MSIM_24230 carbon-phosphorus lyase\tK06164 phnI; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [EC:2.7.8.37]" }, { "name":"MSIM_24250 hypothetical protein\tK06166 phnG; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG [EC:2.7.8.37]" }, { "name":"MSIM_24240 phnH; carbon-phosphorus lyase subunit PhnH\tK06165 phnH; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH [EC:2.7.8.37]" }, { "name":"MSIM_24210 ABC transporter\tK05780 phnL; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [EC:2.7.8.37]" }, { "name":"MSIM_24200 phnM; phosphonate metabolism protein PhnM\tK06162 phnM; alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase [EC:3.6.1.63]" } ] }, { "name":"00450 Selenocompound metabolism [PATH:msim00450]", "children":[ { "name":"MSIM_37140 metB; cystathionine gamma-synthase\tK01739 metB; cystathionine gamma-synthase [EC:2.5.1.48]" }, { "name":"MSIM_44450 putative cystathionine beta-lyase\tK14155 patB; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]" }, { "name":"MSIM_46910 5-methyltetrahydrofolate--homocysteine methyltransferase MetH\tK00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]" }, { "name":"MSIM_37750 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase\tK00549 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14]" }, { "name":"MSIM_02170 csd; putative cysteine desulfurase\tK11717 sufS; cysteine desulfurase \/ selenocysteine lyase [EC:2.8.1.7 4.4.1.16]" }, { "name":"MSIM_43020 csd1; putative cysteine desulfurase 1\tK11717 sufS; cysteine desulfurase \/ selenocysteine lyase [EC:2.8.1.7 4.4.1.16]" }, { "name":"MSIM_02120 trx; thiol reductase thioredoxin\tK00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]" }, { "name":"MSIM_15270 fused response regulator\/thioredoxin-disulfide reductase\tK00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]" }, { "name":"MSIM_25220 trxB; thioredoxin reductase\tK00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]" }, { "name":"MSIM_38360 adenylyl-sulfate kinase\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_39440 cysNC; bifunctional enzyme CysN\/CysC\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_38370 sulfate adenylyltransferase\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_39430 cysD; sulfate adenylyltransferase subunit 2\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_23320 selD; selenide, water dikinase\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]" }, { "name":"MSIM_23310 selA; L-seryl-tRNA(Sec) selenium transferase\tK01042 selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]" }, { "name":"MSIM_36400 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]" } ] }, { "name":"00460 Cyanoamino acid metabolism [PATH:msim00460]", "children":[ { "name":"MSIM_21050 bglS; beta-glucosidase\tK05349 bglX; beta-glucosidase [EC:3.2.1.21]" }, { "name":"MSIM_20980 nitrilase\tK01501 E3.5.5.1; nitrilase [EC:3.5.5.1]" }, { "name":"MSIM_30410 ggtA; bifunctional cephalosporin acylase\/gamma-glutamyltranspeptidase\tK00681 ggt; gamma-glutamyltranspeptidase \/ glutathione hydrolase [EC:2.3.2.2 3.4.19.13]" }, { "name":"MSIM_01440 ansA; putative L-asparaginase\tK01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1]" }, { "name":"MSIM_37280 glyA1; serine hydroxymethyltransferase 1\tK00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]" }, { "name":"MSIM_09890 formamidase\tK01455 fmdA; formamidase [EC:3.5.1.49]" } ] }, { "name":"00470 D-Amino acid metabolism [PATH:msim00470]", "children":[ { "name":"MSIM_14900 alr; alanine racemase\tK01775 alr; alanine racemase [EC:5.1.1.1]" }, { "name":"MSIM_08120 ddl; D-alanine--D-alanine ligase\tK01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]" }, { "name":"MSIM_30590 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ\tK23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ \/ glutaminase [EC:6.3.5.3 3.5.1.2]" }, { "name":"MSIM_40010 murI; glutamate racemase\tK01776 murI; glutamate racemase [EC:5.1.1.3]" }, { "name":"MSIM_46300 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase\tK01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]" }, { "name":"MSIM_05220 dapF; diaminopimelate epimerase\tK01778 dapF; diaminopimelate epimerase [EC:5.1.1.7]" }, { "name":"MSIM_26930 lysA_1; diaminopimelate decarboxylase\tK01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]" }, { "name":"MSIM_36710 lysA_2; diaminopimelate decarboxylase\tK01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]" }, { "name":"MSIM_39600 lysA_3; diaminopimelate decarboxylase\tK01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]" }, { "name":"MSIM_40750 aao_1; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_50640 aao_2; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" } ] }, { "name":"00480 Glutathione metabolism [PATH:msim00480]", "children":[ { "name":"MSIM_30410 ggtA; bifunctional cephalosporin acylase\/gamma-glutamyltranspeptidase\tK00681 ggt; gamma-glutamyltranspeptidase \/ glutathione hydrolase [EC:2.3.2.2 3.4.19.13]" }, { "name":"MSIM_28960 UPF0271 protein\tK07160 pxpA; 5-oxoprolinase (ATP-hydrolysing) subunit A [EC:3.5.2.9]" }, { "name":"MSIM_04360 putative glutamate--cysteine ligase 2-3\tK06048 gshA; glutamate---cysteine ligase \/ carboxylate-amine ligase [EC:6.3.2.2 6.3.-.-]" }, { "name":"MSIM_18280 putative glutamate--cysteine ligase 2\tK06048 gshA; glutamate---cysteine ligase \/ carboxylate-amine ligase [EC:6.3.2.2 6.3.-.-]" }, { "name":"MSIM_27460 egtA; glutamate--cysteine ligase EgtA\tK01919 gshA; glutamate---cysteine ligase [EC:6.3.2.2]" }, { "name":"MSIM_45710 pepA_2; putative cytosol aminopeptidase\tK01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]" }, { "name":"MSIM_41610 pepN; aminopeptidase\tK01256 pepN; aminopeptidase N [EC:3.4.11.2]" }, { "name":"MSIM_14170 icd2; isocitrate dehydrogenase, NADP-dependent\tK00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]" }, { "name":"MSIM_37590 gnd2; 6-phosphogluconate dehydrogenase (decarboxylating)\tK00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]" }, { "name":"MSIM_51680 gnd; 6-phosphogluconate dehydrogenase, decarboxylating\tK00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]" }, { "name":"MSIM_02320 zwf2; glucose-6-phosphate 1-dehydrogenase 2\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_37580 zwf1; glucose-6-phosphate 1-dehydrogenase 1\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_49840 zwf; glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_11860 glutathione peroxidase\tK00432 gpx; glutathione peroxidase [EC:1.11.1.9]" }, { "name":"MSIM_25870 hypothetical protein\tK01581 E4.1.1.17; ornithine decarboxylase [EC:4.1.1.17]" }, { "name":"MSIM_04020 speE; polyamine aminopropyltransferase\tK00797 speE; spermidine synthase [EC:2.5.1.16]" } ] } ] }, { "name":"09107 Glycan biosynthesis and metabolism", "children":[ { "name":"00520 Amino sugar and nucleotide sugar metabolism [PATH:msim00520]", "children":[ { "name":"MSIM_36690 glmU; bifunctional protein GlmU\tK04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase \/ glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]" }, { "name":"MSIM_39810 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase\tK00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]" }, { "name":"MSIM_17710 murB; UDP-N-acetylenolpyruvoylglucosamine reductase\tK00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]" }, { "name":"MSIM_20290 lpqI; hypothetical protein\tK01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52]" }, { "name":"MSIM_14130 nagA; N-acetylglucosamine-6-phosphate deacetylase\tK01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]" }, { "name":"MSIM_15060 glmM; phosphoglucosamine mutase\tK03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10]" }, { "name":"MSIM_14990 glmS; glutamine--fructose-6-phosphate aminotransferase [isomerizing]\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]" }, { "name":"MSIM_33470 hypothetical protein\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]" }, { "name":"MSIM_34510 fructokinase\tK00847 E2.7.1.4; fructokinase [EC:2.7.1.4]" }, { "name":"MSIM_34670 pgi; glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]" }, { "name":"MSIM_13010 manA; mannose-6-phosphate isomerase, class I\tK01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]" }, { "name":"MSIM_36270 NAD-dependent dehydratase\tK08678 UXS1; UDP-glucuronate decarboxylase [EC:4.1.1.35]" }, { "name":"MSIM_16360 sugar kinase\tK25026 glk; glucokinase [EC:2.7.1.2]" }, { "name":"MSIM_04990 ppgK; polyphosphate glucokinase\tK00886 ppgK; polyphosphate glucokinase [EC:2.7.1.63]" }, { "name":"MSIM_09910 pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific\tK01835 pgm; phosphoglucomutase [EC:5.4.2.2]" }, { "name":"MSIM_35000 galU; UDP-glucose pyrophosphorylase\tK00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]" }, { "name":"MSIM_01680 ugd_1; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_11540 ugd_2; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_19380 udgA; UDP-glucose 6-dehydrogenase UdgA\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_36260 ugd_3; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_16670 galK; galactokinase\tK00849 galK; galactokinase [EC:2.7.1.6]" }, { "name":"MSIM_16680 galT; galactose-1-phosphate uridylyltransferase\tK00965 galT; UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]" }, { "name":"MSIM_07300 hypothetical protein\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_17510 hypothetical protein\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_28310 galE1; UDP-glucose 4-epimerase\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_36290 NAD-dependent dehydratase\tK01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]" }, { "name":"MSIM_25900 glf; UDP-galactopyranose mutase\tK01854 glf; UDP-galactopyranose mutase [EC:5.4.99.9]" }, { "name":"MSIM_13030 manB; phosphomannomutase\/phosphoglucomutase\tK01840 manB; phosphomannomutase [EC:5.4.2.8]" }, { "name":"MSIM_13860 pmmB; phosphomannomutase\tK01840 manB; phosphomannomutase [EC:5.4.2.8]" }, { "name":"MSIM_13120 rmlA2; GDP-mannose pyrophosphorylase\tK00966 GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]" }, { "name":"MSIM_38630 glgC; glucose-1-phosphate adenylyltransferase\tK00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]" }, { "name":"MSIM_19350 rmlA; glucose-1-phosphate thymidylyltransferase\tK00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]" } ] }, { "name":"00541 Biosynthesis of various nucleotide sugars [PATH:msim00541]", "children":[ { "name":"MSIM_36690 glmU; bifunctional protein GlmU\tK04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase \/ glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]" }, { "name":"MSIM_06620 gmhA_1; phosphoheptose isomerase\tK03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]" }, { "name":"MSIM_11500 gmhA_2; phosphoheptose isomerase\tK03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]" }, { "name":"MSIM_36040 gmhA_3; phosphoheptose isomerase\tK03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]" }, { "name":"MSIM_36030 GHMP kinase\tK07031 hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168]" }, { "name":"MSIM_36050 gmhB; D,D-heptose 1,7-bisphosphate phosphatase\tK03273 gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]" }, { "name":"MSIM_11510 bifunctional protein HldE\tK03272 gmhC; D-beta-D-heptose 7-phosphate kinase \/ D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70]" }, { "name":"MSIM_35000 galU; UDP-glucose pyrophosphorylase\tK00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]" }, { "name":"MSIM_01680 ugd_1; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_11540 ugd_2; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_19380 udgA; UDP-glucose 6-dehydrogenase UdgA\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_36260 ugd_3; UDP-glucose 6-dehydrogenase\tK00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]" }, { "name":"MSIM_19350 rmlA; glucose-1-phosphate thymidylyltransferase\tK00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]" }, { "name":"MSIM_11460 rfbB; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15310 rmlB1; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15320 rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase\tK01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]" }, { "name":"MSIM_36330 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase\tK01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]" }, { "name":"MSIM_13140 rmlD; NAD(P)-dependent oxidoreductase\tK00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]" }, { "name":"MSIM_13120 rmlA2; GDP-mannose pyrophosphorylase\tK00966 GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]" }, { "name":"MSIM_01660 gmdA; GDP-mannose 4,6-dehydratase\tK01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47]" }, { "name":"MSIM_01650 epiA; GDP-L-fucose synthase\tK02377 TSTA3; GDP-L-fucose synthase [EC:1.1.1.271]" } ] }, { "name":"00510 N-Glycan biosynthesis" }, { "name":"00513 Various types of N-glycan biosynthesis" }, { "name":"00512 Mucin type O-glycan biosynthesis" }, { "name":"00515 Mannose type O-glycan biosynthesis [PATH:msim00515]", "children":[ { "name":"MSIM_36120 pmt; putative dolichyl-phosphate-mannose--protein mannosyltransferase\tK00728 POMT; dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]" } ] }, { "name":"00514 Other types of O-glycan biosynthesis [PATH:msim00514]", "children":[ { "name":"MSIM_36120 pmt; putative dolichyl-phosphate-mannose--protein mannosyltransferase\tK00728 POMT; dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]" } ] }, { "name":"00532 Glycosaminoglycan biosynthesis - chondroitin sulfate \/ dermatan sulfate" }, { "name":"00534 Glycosaminoglycan biosynthesis - heparan sulfate \/ heparin" }, { "name":"00533 Glycosaminoglycan biosynthesis - keratan sulfate" }, { "name":"00531 Glycosaminoglycan degradation" }, { "name":"00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis" }, { "name":"00601 Glycosphingolipid biosynthesis - lacto and neolacto series" }, { "name":"00603 Glycosphingolipid biosynthesis - globo and isoglobo series" }, { "name":"00604 Glycosphingolipid biosynthesis - ganglio series" }, { "name":"00511 Other glycan degradation" }, { "name":"00540 Lipopolysaccharide biosynthesis" }, { "name":"00542 O-Antigen repeat unit biosynthesis [PATH:msim00542]", "children":[ { "name":"MSIM_39690 wecA; decaprenyl-phosphate N-acetylglucosaminephosphotransferase\tK02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate\/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]" } ] }, { "name":"00550 Peptidoglycan biosynthesis [PATH:msim00550]", "children":[ { "name":"MSIM_39810 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase\tK00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]" }, { "name":"MSIM_17710 murB; UDP-N-acetylenolpyruvoylglucosamine reductase\tK00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]" }, { "name":"MSIM_46330 murC; UDP-N-acetylmuramate--L-alanine ligase\tK01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]" }, { "name":"MSIM_46300 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase\tK01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]" }, { "name":"MSIM_46270 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\tK01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]" }, { "name":"MSIM_08120 ddl; D-alanine--D-alanine ligase\tK01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]" }, { "name":"MSIM_46280 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase\tK01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]" }, { "name":"MSIM_46820 uppP; undecaprenyl-diphosphatase\tK06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]" }, { "name":"MSIM_46290 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase\tK01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]" }, { "name":"MSIM_46320 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase\tK02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]" }, { "name":"MSIM_24920 rodA; putative FtsW-like protein\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_46310 ftsW; cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_46230 pbpB; penicillin-binding protein 2\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]" }, { "name":"MSIM_24930 pbpA; penicillin-binding protein A\tK05364 pbpA; penicillin-binding protein A" }, { "name":"MSIM_07480 dacB2; D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]" }, { "name":"MSIM_14110 D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]" }, { "name":"MSIM_28370 D-alanyl-D-alanine carboxypeptidase\/D-alanyl-D-alanine-endopeptidase\tK07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase\/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]" }, { "name":"MSIM_27320 putative Mur ligase family protein\tK23393 murT; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13]" }, { "name":"MSIM_27310 cobQ2; glutamine amidotransferase\tK07009 gatD; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13]" } ] }, { "name":"00552 Teichoic acid biosynthesis [PATH:msim00552]", "children":[ { "name":"MSIM_46820 uppP; undecaprenyl-diphosphatase\tK06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]" }, { "name":"MSIM_39690 wecA; decaprenyl-phosphate N-acetylglucosaminephosphotransferase\tK02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate\/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]" } ] }, { "name":"00571 Lipoarabinomannan (LAM) biosynthesis [PATH:msim00571]", "children":[ { "name":"MSIM_04150 pimA; phosphatidyl-myo-inositol mannosyltransferase\tK08256 pimA; phosphatidyl-myo-inositol alpha-mannosyltransferase [EC:2.4.1.345]" }, { "name":"MSIM_45980 GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase\tK13668 pimB; phosphatidyl-myo-inositol dimannoside synthase [EC:2.4.1.346]" }, { "name":"MSIM_04160 phosphatidylinositol mannoside acyltransferase\tK22311 ptfP1; phosphatidylinositol dimannoside acyltransferase [EC:2.3.1.265]" }, { "name":"MSIM_44630 GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol dimannoside mannosyltransferase\tK14335 pimC; alpha-1,6-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_38170 pimE; polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase\tK13669 pimE; alpha-1,2-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_00530 mannosyltransferase\tK14340 K14340; mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_19580 mannosyltransferase\tK14340 K14340; mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_46140 hypothetical protein\tK14337 mptA; alpha-1,6-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_02220 membrane protein\tK14339 mptB; alpha-1,6-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_46050 hypothetical protein\tK13671 K13671; alpha-1,2-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_26100 embC; putative arabinosyltransferase C\tK11387 embC; arabinosyltransferase C [EC:2.4.2.-]" }, { "name":"MSIM_25940 membrane protein\tK13687 aftB; arabinofuranosyltransferase [EC:2.4.2.-]" }, { "name":"MSIM_04740 aftC; alpha-(1->3)-arabinofuranosyltransferase\tK16647 aftC; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.47]" }, { "name":"MSIM_20330 membrane protein\tK16648 aftD; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.-]" }, { "name":"MSIM_17070 hypothetical protein\tK23176 mtxT; methylthioxylose transferase" } ] }, { "name":"00572 Arabinogalactan biosynthesis - Mycobacterium [PATH:msim00572]", "children":[ { "name":"MSIM_39690 wecA; decaprenyl-phosphate N-acetylglucosaminephosphotransferase\tK02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate\/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]" }, { "name":"MSIM_13130 wbbL; N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase\tK16870 wbbL; N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase [EC:2.4.1.289]" }, { "name":"MSIM_26190 galactofuranosyl transferase GlfT1\tK16649 glft1; rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3\/1,4-galactofuranosyltransferase [EC:2.4.1.287]" }, { "name":"MSIM_25910 glfT2; galactofuranosyl transferase GlfT2\tK16650 glft2; galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5\/1,6-galactofuranosyltransferase [EC:2.4.1.288]" }, { "name":"MSIM_26110 aftA; arabinofuranosyltransferase AftA\tK13686 aftA; galactan 5-O-arabinofuranosyltransferase [EC:2.4.2.46]" }, { "name":"MSIM_25940 membrane protein\tK13687 aftB; arabinofuranosyltransferase [EC:2.4.2.-]" }, { "name":"MSIM_04740 aftC; alpha-(1->3)-arabinofuranosyltransferase\tK16647 aftC; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.47]" }, { "name":"MSIM_26050 embA; putative arabinosyltransferase A\tK11385 embA; arabinosyltransferase A [EC:2.4.2.-]" }, { "name":"MSIM_26040 embB; putative arabinosyltransferase B\tK11386 embB; arabinosyltransferase B [EC:2.4.2.-]" }, { "name":"MSIM_20330 membrane protein\tK16648 aftD; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.-]" }, { "name":"MSIM_13150 hypothetical protein\tK27775 lcp1; cell wall biosynthesis protein" }, { "name":"MSIM_22120 fbpC; diacylglycerol acyltransferase\/mycolyltransferase Ag85C\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_25950 fbpA; diacylglycerol acyltransferase\/mycolyltransferase Ag85A\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_50860 fbpB; diacylglycerol acyltransferase\/mycolyltransferase Ag85B\tK18851 fbp; diacylglycerol O-acyltransferase \/ trehalose O-mycolyltransferase \/ mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]" }, { "name":"MSIM_26220 membrane protein\tK22902 K22902; D-galactosaminyltransferase" } ] }, { "name":"00543 Exopolysaccharide biosynthesis [PATH:msim00543]", "children":[ { "name":"MSIM_39690 wecA; decaprenyl-phosphate N-acetylglucosaminephosphotransferase\tK02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate\/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]" }, { "name":"MSIM_42980 cysE; serine acetyltransferase\tK00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]" } ] } ] }, { "name":"09108 Metabolism of cofactors and vitamins", "children":[ { "name":"00730 Thiamine metabolism [PATH:msim00730]", "children":[ { "name":"MSIM_18380 thiC; phosphomethylpyrimidine synthase\tK03147 thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]" }, { "name":"MSIM_18390 thiD; hydroxymethylpyrimidine\/phosphomethylpyrimidine kinase\tK00941 thiD; hydroxymethylpyrimidine\/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]" }, { "name":"MSIM_08500 iscS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]" }, { "name":"MSIM_18540 thiO; thiamine biosynthesis oxidoreductase ThiO\tK03153 thiO; glycine oxidase [EC:1.4.3.19]" }, { "name":"MSIM_04840 dxs; 1-deoxy-D-xylulose-5-phosphate synthase\tK01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]" }, { "name":"MSIM_18520 thiG; thiazole synthase\tK03149 thiG; thiazole synthase [EC:2.8.1.10]" }, { "name":"MSIM_18550 thiE; thiamine-phosphate synthase\tK00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]" }, { "name":"MSIM_08100 thiL; thiamine-monophosphate kinase\tK00946 thiL; thiamine-monophosphate kinase [EC:2.7.4.16]" }, { "name":"MSIM_12500 ribosome small subunit-dependent GTPase A\tK06949 rsgA; ribosome biogenesis GTPase \/ thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]" }, { "name":"MSIM_15540 adk; adenylate kinase\tK00939 adk; adenylate kinase [EC:2.7.4.3]" } ] }, { "name":"00740 Riboflavin metabolism [PATH:msim00740]", "children":[ { "name":"MSIM_02550 ribBA; riboflavin biosynthesis protein RibBA\tK14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase \/ GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]" }, { "name":"MSIM_02610 ribG; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase\/5-amino-6-(5-phosphoribosylamino)uracil reductase\tK11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase \/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]" }, { "name":"MSIM_02540 ribH; 6,7-dimethyl-8-ribityllumazine synthase\tK00794 ribH; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]" }, { "name":"MSIM_02580 ribE; riboflavin synthase\tK00793 ribE; riboflavin synthase [EC:2.5.1.9]" }, { "name":"MSIM_05930 ribF; riboflavin biosynthesis protein\tK11753 ribF; riboflavin kinase \/ FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]" }, { "name":"MSIM_19740 oxidoreductase\tK04719 bluB; 5,6-dimethylbenzimidazole synthase [EC:1.13.11.79]" } ] }, { "name":"00750 Vitamin B6 metabolism [PATH:msim00750]", "children":[ { "name":"MSIM_33070 pdxH; pyridoxine\/pyridoxamine 5'-phosphate oxidase\tK00275 pdxH; pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]" }, { "name":"MSIM_04210 oxidoreductase\tK05275 E1.1.1.65; pyridoxine 4-dehydrogenase [EC:1.1.1.65]" }, { "name":"MSIM_10830 oxidoreductase\tK05275 E1.1.1.65; pyridoxine 4-dehydrogenase [EC:1.1.1.65]" }, { "name":"MSIM_16980 aldo\/keto reductase\tK05275 E1.1.1.65; pyridoxine 4-dehydrogenase [EC:1.1.1.65]" }, { "name":"MSIM_33660 oxidoreductase\tK05275 E1.1.1.65; pyridoxine 4-dehydrogenase [EC:1.1.1.65]" }, { "name":"MSIM_33010 serC; putative phosphoserine aminotransferase\tK00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]" }, { "name":"MSIM_39620 thrC; threonine synthase\tK01733 thrC; threonine synthase [EC:4.2.3.1]" }, { "name":"MSIM_04090 pdxS; pyridoxal 5'-phosphate synthase subunit PdxS\tK06215 pdxS; pyridoxal 5'-phosphate synthase pdxS subunit [EC:4.3.3.6]" }, { "name":"MSIM_04070 pdxT; pyridoxal 5'-phosphate synthase subunit PdxT\tK08681 pdxT; pyridoxal 5'-phosphate synthase pdxT subunit [EC:4.3.3.6]" } ] }, { "name":"00760 Nicotinate and nicotinamide metabolism [PATH:msim00760]", "children":[ { "name":"MSIM_01040 nadB; L-aspartate oxidase\tK00278 nadB; L-aspartate oxidase [EC:1.4.3.16]" }, { "name":"MSIM_01050 nadA; quinolinate synthase A\tK03517 nadA; quinolinate synthase [EC:2.5.1.72]" }, { "name":"MSIM_01030 nadC; nicotinate-nucleotide pyrophosphorylase\tK00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]" }, { "name":"MSIM_39950 pncB1; nicotinate phosphoribosyltransferase pncB1\tK00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21]" }, { "name":"MSIM_13850 punA; purine nucleoside phosphorylase\tK03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]" }, { "name":"MSIM_42050 nadD; putative nicotinate-nucleotide adenylyltransferase\tK00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]" }, { "name":"MSIM_36730 nucleoside triphosphate pyrophosphohydrolase\tK04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]" }, { "name":"MSIM_12090 nudC; NADH pyrophosphatase\tK03426 NUDT12_13; NAD+ diphosphatase [EC:3.6.1.22]" }, { "name":"MSIM_41970 nadE; glutamine-dependent NAD(+) synthetase\tK01950 E6.3.5.1; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]" }, { "name":"MSIM_47900 pncA; amidase\tK08281 pncA; nicotinamidase\/pyrazinamidase [EC:3.5.1.19 3.5.1.-]" }, { "name":"MSIM_38060 cobB_2; NAD-dependent protein deacylase\tK12410 cobB; NAD-dependent protein deacetylase\/lipoamidase [EC:2.3.1.286 2.3.1.313]" }, { "name":"MSIM_54070 nadK; NAD kinase\tK00858 ppnK; NAD+ kinase [EC:2.7.1.23]" }, { "name":"MSIM_05100 sthA; putative soluble pyridine nucleotide transhydrogenase\tK00322 sthA; NAD(P) transhydrogenase [EC:1.6.1.1]" }, { "name":"MSIM_06160 alanine dehydrogenase\tK00324 pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]" }, { "name":"MSIM_06170 pntA; NAD(P) transhydrogenase subunit alpha\tK00324 pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]" }, { "name":"MSIM_21680 pntAB; NAD(P) transhydrogenase subunit alpha\tK00324 pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]" }, { "name":"MSIM_21690 pntAa; NAD(P) transhydrogenase subunit alpha\tK00324 pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]" }, { "name":"MSIM_06180 pntB_1; NAD(P) transhydrogenase subunit beta\tK00325 pntB; proton-translocating NAD(P)+ transhydrogenase subunit beta [EC:7.1.1.1]" }, { "name":"MSIM_21670 pntB_2; NAD(P) transhydrogenase subunit beta\tK00325 pntB; proton-translocating NAD(P)+ transhydrogenase subunit beta [EC:7.1.1.1]" }, { "name":"MSIM_20400 gabD1; succinate-semialdehyde dehydrogenase [NADP(+)] 1\tK00135 gabD; succinate-semialdehyde dehydrogenase \/ glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]" } ] }, { "name":"00770 Pantothenate and CoA biosynthesis [PATH:msim00770]", "children":[ { "name":"MSIM_08320 ilvB1; acetolactate synthase large subunit IlvB1\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_15500 acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_20390 putative acetolactate synthase large subunit IlvB\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_22300 acetolactate synthase large subunit\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_29640 ilvX; putative acetolactate synthase large subunit IlvX\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_44650 alsS; acetolactate synthase\tK01652 E2.2.1.6L; acetolactate synthase I\/II\/III large subunit [EC:2.2.1.6]" }, { "name":"MSIM_08310 ilvH; putative acetolactate synthase small subunit\tK01653 E2.2.1.6S; acetolactate synthase I\/III small subunit [EC:2.2.1.6]" }, { "name":"MSIM_08300 ilvC; ketol-acid reductoisomerase (NADP(+))\tK00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]" }, { "name":"MSIM_21020 ilvD; dihydroxy-acid dehydratase\tK01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]" }, { "name":"MSIM_45440 panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase\tK00606 panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]" }, { "name":"MSIM_03480 putative 2-dehydropantoate 2-reductase\tK00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169]" }, { "name":"MSIM_06150 panE; 2-dehydropantoate 2-reductase\tK00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169]" }, { "name":"MSIM_23620 hypothetical protein\tK00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169]" }, { "name":"MSIM_28660 panC; pantothenate synthetase\tK01918 panC; pantoate--beta-alanine ligase [EC:6.3.2.1]" }, { "name":"MSIM_37270 coaA; pantothenate kinase\tK00867 coaA; type I pantothenate kinase [EC:2.7.1.33]" }, { "name":"MSIM_28680 coaX; type III pantothenate kinase\tK03525 coaX; type III pantothenate kinase [EC:2.7.1.33]" }, { "name":"MSIM_02870 coaBC; coenzyme A biosynthesis bifunctional protein CoaBC\tK13038 coaBC; phosphopantothenoylcysteine decarboxylase \/ phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5]" }, { "name":"MSIM_36730 nucleoside triphosphate pyrophosphohydrolase\tK04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]" }, { "name":"MSIM_07930 coaD; phosphopantetheine adenylyltransferase\tK00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]" }, { "name":"MSIM_00650 coaE; dephospho-CoA kinase\tK00859 coaE; dephospho-CoA kinase [EC:2.7.1.24]" }, { "name":"MSIM_41000 acpS; holo-[acyl-carrier-protein] synthase\tK00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]" }, { "name":"MSIM_05990 4'-phosphopantetheinyl transferase\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]" }, { "name":"MSIM_06000 hypothetical protein\tK28885 pptH; [acyl-carrier-protein] phosphodiesterase [EC:3.1.4.14]" }, { "name":"MSIM_45740 ilvE; branched-chain-amino-acid aminotransferase\tK00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]" }, { "name":"MSIM_30070 putative hydrolase\tK06016 pydC; beta-ureidopropionase \/ N-carbamoyl-L-amino-acid hydrolase [EC:3.5.1.6 3.5.1.87]" }, { "name":"MSIM_28670 panD; aspartate 1-decarboxylase\tK01579 panD; aspartate 1-decarboxylase [EC:4.1.1.11]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" } ] }, { "name":"00780 Biotin metabolism [PATH:msim00780]", "children":[ { "name":"MSIM_12430 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_20250 fabG4; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_22950 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_31770 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34040 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34210 fabG_3; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34260 3-ketoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35190 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35590 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35600 hypothetical protein\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_40200 fabG2; putative oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_01170 bioF1; 8-amino-7-oxononanoate synthase 1\tK00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]" }, { "name":"MSIM_01180 bioA; adenosylmethionine-8-amino-7-oxononanoate aminotransferase\tK00833 bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]" }, { "name":"MSIM_01160 bioD; ATP-dependent dethiobiotin synthetase BioD\tK01935 bioD; dethiobiotin synthetase [EC:6.3.3.3]" }, { "name":"MSIM_01100 bioB; biotin synthase\tK01012 bioB; biotin synthase [EC:2.8.1.6]" }, { "name":"MSIM_13570 birA; biotin--[acetyl-CoA-carboxylase] ligase\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]" } ] }, { "name":"00785 Lipoic acid metabolism [PATH:msim00785]", "children":[ { "name":"MSIM_45640 lipB; octanoyltransferase\tK03801 lipB; lipoyl(octanoyl) transferase [EC:2.3.1.181]" }, { "name":"MSIM_45630 lipA; lipoyl synthase\tK03644 lipA; lipoyl synthase [EC:2.8.1.8]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_07830 pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45200 aceE; pyruvate dehydrogenase E1 component\tK00163 aceE; pyruvate dehydrogenase E1 component [EC:1.2.4.1]" }, { "name":"MSIM_45660 hypothetical protein\tK00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]" }, { "name":"MSIM_38900 kgd; multifunctional 2-oxoglutarate metabolism enzyme\tK01616 kgd; multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]" }, { "name":"MSIM_34130 bkdA; 2-oxoisovalerate dehydrogenase E1\tK11381 bkdA; 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]" }, { "name":"MSIM_51750 gcvP; putative glycine dehydrogenase (decarboxylating)\tK00281 GLDC; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]" }, { "name":"MSIM_45730 gcvT; aminomethyltransferase\tK00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]" }, { "name":"MSIM_46520 gcvH_1; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" }, { "name":"MSIM_51810 gcvH_2; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" } ] }, { "name":"00790 Folate biosynthesis [PATH:msim00790]", "children":[ { "name":"MSIM_28590 folE; GTP cyclohydrolase 1\tK01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16]" }, { "name":"MSIM_28610 folB; dihydroneopterin aldolase\tK01633 folB; 7,8-dihydroneopterin aldolase\/epimerase\/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81]" }, { "name":"MSIM_28620 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase\tK00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]" }, { "name":"MSIM_28600 folP1; dihydropteroate synthase\tK00796 folP; dihydropteroate synthase [EC:2.5.1.15]" }, { "name":"MSIM_05510 folA; dihydrofolate reductase\tK00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]" }, { "name":"MSIM_41790 folC; dihydrofolate synthase\tK11754 folC; dihydrofolate synthase \/ folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]" }, { "name":"MSIM_02550 ribBA; riboflavin biosynthesis protein RibBA\tK14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase \/ GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]" }, { "name":"MSIM_24960 trpG; glutamine amidotransferase\tK01664 pabA; para-aminobenzoate synthetase component II [EC:2.6.1.85]" }, { "name":"MSIM_36140 aminodeoxychorismate synthase component I\tK01665 pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]" }, { "name":"MSIM_30910 4-amino-4-deoxychorismate lyase\tK02619 pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]" }, { "name":"MSIM_38180 putative pterin-4-alpha-carbinolamine dehydratase\tK01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]" }, { "name":"MSIM_32880 moaA2; GTP 3',8-cyclase 2\tK03639 moaA; GTP 3',8-cyclase [EC:4.1.99.22]" }, { "name":"MSIM_32820 moaC2; cyclic pyranopterin monophosphate synthase accessory protein 2\tK03637 moaC; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]" }, { "name":"MSIM_32840 moaE2; molybdopterin synthase catalytic subunit 2\tK03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12]" }, { "name":"MSIM_18170 moeA2; molybdopterin molybdenumtransferase\tK03750 moeA; molybdopterin molybdotransferase [EC:2.10.1.1]" }, { "name":"MSIM_35010 moeA1; molybdopterin molybdenumtransferase\tK03750 moeA; molybdopterin molybdotransferase [EC:2.10.1.1]" }, { "name":"MSIM_18990 hypothetical protein\tK07141 mocA; molybdenum cofactor cytidylyltransferase [EC:2.7.7.76]" }, { "name":"MSIM_41740 mobA; putative molybdenum cofactor guanylyltransferase\tK03752 mobA; molybdenum cofactor guanylyltransferase [EC:2.7.7.77]" } ] }, { "name":"00670 One carbon pool by folate [PATH:msim00670]", "children":[ { "name":"MSIM_05510 folA; dihydrofolate reductase\tK00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]" }, { "name":"MSIM_14280 folD; bifunctional protein FolD\tK01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) \/ methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]" }, { "name":"MSIM_37280 glyA1; serine hydroxymethyltransferase 1\tK00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]" }, { "name":"MSIM_34790 purN; phosphoribosylglycinamide formyltransferase\tK11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]" }, { "name":"MSIM_34800 purH; bifunctional purine biosynthesis protein PurH\tK00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase \/ IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]" }, { "name":"MSIM_45730 gcvT; aminomethyltransferase\tK00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]" }, { "name":"MSIM_46910 5-methyltetrahydrofolate--homocysteine methyltransferase MetH\tK00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]" }, { "name":"MSIM_05520 thyA; thymidylate synthase\tK00560 thyA; thymidylate synthase [EC:2.1.1.45]" }, { "name":"MSIM_05460 thyX; flavin-dependent thymidylate synthase\tK03465 thyX; thymidylate synthase (FAD) [EC:2.1.1.148]" }, { "name":"MSIM_34990 5-formyltetrahydrofolate cyclo-ligase\tK01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]" }, { "name":"MSIM_41700 mmuM; homocysteine S-methyltransferase\tK00547 mmuM; homocysteine S-methyltransferase [EC:2.1.1.10]" }, { "name":"MSIM_02860 metK; S-adenosylmethionine synthase\tK00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]" }, { "name":"MSIM_12940 ahcY; adenosylhomocysteinase\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]" }, { "name":"MSIM_51750 gcvP; putative glycine dehydrogenase (decarboxylating)\tK00281 GLDC; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_46520 gcvH_1; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" }, { "name":"MSIM_51810 gcvH_2; glycine cleavage system H protein\tK02437 gcvH; glycine cleavage system H protein" }, { "name":"MSIM_19210 betB; NAD\/NADP-dependent betaine aldehyde dehydrogenase\tK00130 betB; betaine-aldehyde dehydrogenase [EC:1.2.1.8]" }, { "name":"MSIM_37120 cbs; cystathionine beta-synthase\tK01697 CBS; cystathionine beta-synthase [EC:4.2.1.22]" } ] }, { "name":"00830 Retinol metabolism" }, { "name":"00860 Porphyrin metabolism [PATH:msim00860]", "children":[ { "name":"MSIM_08220 gltX; glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]" }, { "name":"MSIM_17410 hemA; glutamyl-tRNA reductase\tK02492 hemA; glutamyl-tRNA reductase [EC:1.2.1.70]" }, { "name":"MSIM_17250 hemL; glutamate-1-semialdehyde 2,1-aminomutase\tK01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]" }, { "name":"MSIM_17380 hemB; delta-aminolevulinic acid dehydratase\tK01698 hemB; porphobilinogen synthase [EC:4.2.1.24]" }, { "name":"MSIM_17400 hemC; porphobilinogen deaminase\tK01749 hemC; hydroxymethylbilane synthase [EC:2.5.1.61]" }, { "name":"MSIM_20080 transcriptional regulator\tK01719 hemD; uroporphyrinogen-III synthase [EC:4.2.1.75]" }, { "name":"MSIM_04790 hemE; uroporphyrinogen decarboxylase\tK01599 hemE; uroporphyrinogen decarboxylase [EC:4.1.1.37]" }, { "name":"MSIM_04780 hemY; protoporphyrinogen oxidase\tK00231 PPOX; protoporphyrinogen\/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15]" }, { "name":"MSIM_01950 hemH; ferrochelatase\tK01772 hemH; protoporphyrin\/coproporphyrin ferrochelatase [EC:4.98.1.1 4.99.1.9]" }, { "name":"MSIM_04770 hypothetical protein\tK00435 hemQ; hydrogen peroxide-dependent heme synthase [EC:1.3.98.5]" }, { "name":"MSIM_17390 hemD; bifunctional uroporphyrinogen-III C-methyltransferase\/uroporphyrinogen-III synthase\tK13542 cobA-hemD; uroporphyrinogen III methyltransferase \/ synthase [EC:2.1.1.107 4.2.1.75]" }, { "name":"MSIM_06400 cysG; uroporphyrinogen-III C-methyltransferase\tK02302 cysG; uroporphyrin-III C-methyltransferase \/ precorrin-2 dehydrogenase \/ sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]" }, { "name":"MSIM_02290 ctaB; protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]" }, { "name":"MSIM_02250 heme A synthase\tK02259 COX15; heme a synthase [EC:1.17.99.9]" }, { "name":"MSIM_47540 cobIJ; cobalamin biosynthesis protein CobIJ\tK13540 cobIJ; precorrin-2 C20-methyltransferase \/ precorrin-3B C17-methyltransferase [EC:2.1.1.130 2.1.1.131]" }, { "name":"MSIM_47560 cobG; precorrin-3B synthase\tK02229 cobG; precorrin-3B synthase [EC:1.14.13.83]" }, { "name":"MSIM_47500 cobM; precorrin-4 C(11)-methyltransferase\tK05936 cobM; precorrin-4\/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271]" }, { "name":"MSIM_34630 cobF; precorrin-6A synthase (deacetylating)\tK02228 cobF; precorrin-6A synthase [EC:2.1.1.152]" }, { "name":"MSIM_47510 cobK; precorrin-6A reductase\tK05895 cobK-cbiJ; precorrin-6A\/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106]" }, { "name":"MSIM_47490 cobL; precorrin-6Y C(5,15)-methyltransferase [decarboxylating]\tK00595 cobL-cbiET; precorrin-6B C5,15-methyltransferase \/ cobalt-precorrin-6B C5,C15-methyltransferase [EC:2.1.1.132 2.1.1.289 2.1.1.196]" }, { "name":"MSIM_47550 cobH; precorrin-8X methylmutase\tK06042 cobH-cbiC; precorrin-8X\/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60]" }, { "name":"MSIM_06410 cobB_1; hydrogenobyrinate a,c-diamide synthase\tK02224 cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11]" }, { "name":"MSIM_47600 cobN; cobalamin biosynthesis protein CobN\tK02230 cobN; cobaltochelatase CobN [EC:6.6.1.2]" }, { "name":"MSIM_09090 cobaltochelatase subunit CobS\tK09882 cobS; cobaltochelatase CobS [EC:6.6.1.2]" }, { "name":"MSIM_09080 cobT_1; cobaltochelatase subunit CobT\tK09883 cobT; cobaltochelatase CobT [EC:6.6.1.2]" }, { "name":"MSIM_39800 Cob(I)yrinic acid a,c-diamide adenosyltransferase\tK00798 MMAB; cob(I)alamin adenosyltransferase [EC:2.5.1.17]" }, { "name":"MSIM_06420 cobO; cob(I)alamin adenosyltransferase\tK19221 cobA; cob(I)alamin adenosyltransferase [EC:2.5.1.17]" }, { "name":"MSIM_06720 cobQ; cobyric acid synthase\tK02232 cobQ; adenosylcobyric acid synthase [EC:6.3.5.10]" }, { "name":"MSIM_45350 cobD; cobalamin biosynthesis protein CobD\tK02227 cbiB; adenosylcobinamide-phosphate synthase [EC:6.3.1.10]" }, { "name":"MSIM_45770 cobU; adenosylcobinamide kinase\tK02231 cobP; adenosylcobinamide kinase \/ adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]" }, { "name":"MSIM_45750 cobS; adenosylcobinamide-GDP ribazoletransferase\tK02233 E2.7.8.26; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]" }, { "name":"MSIM_45760 cobT_2; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase\tK00768 E2.4.2.21; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]" }, { "name":"MSIM_45420 hypothetical protein\tK22316 rhnA-cobC; ribonuclease H \/ adenosylcobalamin\/alpha-ribazole phosphatase [EC:3.1.26.4 3.1.3.73]" }, { "name":"MSIM_06430 hypothetical protein\tK03404 chlD; magnesium chelatase subunit D [EC:6.6.1.1]" }, { "name":"MSIM_34810 magnesium chelatase\tK03405 chlI; magnesium chelatase subunit I [EC:6.6.1.1]" }, { "name":"MSIM_47470 hypothetical protein\tK23825 K23825; F420H(2)-dependent biliverdin reductase [EC:1.3.98.-]" }, { "name":"MSIM_51080 bfr; bacterioferritin\tK03594 bfr; bacterioferritin [EC:1.16.3.1]" }, { "name":"MSIM_25650 bfrB; ferritin\tK22336 bfrB; bacterioferritin B [EC:1.16.3.1]" }, { "name":"MSIM_31620 mmcO; multicopper oxidase MmcO\tK22552 mmcO; multicopper oxidase [EC:1.16.3.1]" } ] }, { "name":"00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:msim00130]", "children":[ { "name":"MSIM_16880 menG; demethylmenaquinone methyltransferase\tK03183 ubiE; demethylmenaquinone methyltransferase \/ 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]" }, { "name":"MSIM_12280 menF; putative isochorismate synthase MenF\tK02361 entC; isochorismate synthase [EC:5.4.4.2]" }, { "name":"MSIM_16920 menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase\tK02551 menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9]" }, { "name":"MSIM_16940 menC; o-succinylbenzoate synthase\tK02549 menC; o-succinylbenzoate synthase [EC:4.2.1.113]" }, { "name":"MSIM_17060 menE; putative 2-succinylbenzoate--CoA ligase\tK01911 menE; o-succinylbenzoate---CoA ligase [EC:6.2.1.26]" }, { "name":"MSIM_17000 menB; 1,4-dihydroxy-2-naphthoyl-CoA synthase\tK01661 menB; naphthoate synthase [EC:4.1.3.36]" }, { "name":"MSIM_51650 esterase\tK19222 menI; 1,4-dihydroxy-2-naphthoyl-CoA hydrolase [EC:3.1.2.28]" }, { "name":"MSIM_17150 menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase\tK02548 menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]" }, { "name":"MSIM_08290 wrbA; NAD(P)H:quinone oxidoreductase type IV\tK03809 wrbA; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]" } ] } ] }, { "name":"09109 Metabolism of terpenoids and polyketides", "children":[ { "name":"00900 Terpenoid backbone biosynthesis [PATH:msim00900]", "children":[ { "name":"MSIM_04840 dxs; 1-deoxy-D-xylulose-5-phosphate synthase\tK01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]" }, { "name":"MSIM_06790 dxr; 1-deoxy-D-xylulose 5-phosphate reductoisomerase\tK00099 dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]" }, { "name":"MSIM_28870 hypothetical protein\tK00991 ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]" }, { "name":"MSIM_36440 ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase\tK00919 ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]" }, { "name":"MSIM_28880 ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase\tK01770 ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]" }, { "name":"MSIM_06770 ispG; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)\tK03526 gcpE; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]" }, { "name":"MSIM_37430 ispH1; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1\tK03527 ispH; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_08690 fni; isopentenyl-diphosphate delta-isomerase\tK01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]" }, { "name":"MSIM_05620 hypothetical protein\tK13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]" }, { "name":"MSIM_08600 polyprenyl synthetase\tK13787 idsA; geranylgeranyl diphosphate synthase, type I [EC:2.5.1.1 2.5.1.10 2.5.1.29]" }, { "name":"MSIM_46150 idsA2; geranylgeranyl pyrophosphate synthase\tK13787 idsA; geranylgeranyl diphosphate synthase, type I [EC:2.5.1.1 2.5.1.10 2.5.1.29]" }, { "name":"MSIM_37210 short-chain Z-isoprenyl diphosphate synthase\tK12503 uppS; short-chain Z-isoprenyl diphosphate synthase [EC:2.5.1.68]" }, { "name":"MSIM_42840 uppS; decaprenyl diphosphate synthase\tK14215 E2.5.1.86; trans,polycis-decaprenyl diphosphate synthase [EC:2.5.1.86]" } ] }, { "name":"00902 Monoterpenoid biosynthesis" }, { "name":"00909 Sesquiterpenoid and triterpenoid biosynthesis" }, { "name":"00904 Diterpenoid biosynthesis" }, { "name":"00906 Carotenoid biosynthesis [PATH:msim00906]", "children":[ { "name":"MSIM_08620 phytoene synthase\tK02291 crtB; 15-cis-phytoene synthase [EC:2.5.1.32]" }, { "name":"MSIM_08610 phytoene dehydrogenase\tK10027 crtI; phytoene desaturase [EC:1.3.99.26 1.3.99.28 1.3.99.29 1.3.99.31]" }, { "name":"MSIM_08660 dehydrogenase\tK09879 crtU; carotenoid phi-ring synthase \/ carotenoid chi-ring synthase [EC:1.3.99.39 1.3.99.40]" } ] }, { "name":"00905 Brassinosteroid biosynthesis" }, { "name":"00981 Insect hormone biosynthesis" }, { "name":"00908 Zeatin biosynthesis" }, { "name":"00903 Limonene degradation [PATH:msim00903]", "children":[ { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_28550 monooxygenase\tK14733 limB; limonene 1,2-monooxygenase [EC:1.14.13.107]" }, { "name":"MSIM_43700 limonene 1,2-monooxygenase\tK14733 limB; limonene 1,2-monooxygenase [EC:1.14.13.107]" }, { "name":"MSIM_50410 putative monooxygenase (luciferase-like)\tK14733 limB; limonene 1,2-monooxygenase [EC:1.14.13.107]" }, { "name":"MSIM_05340 limonene-1,2-epoxide hydrolase\tK10533 E3.3.2.8; limonene-1,2-epoxide hydrolase [EC:3.3.2.8]" }, { "name":"MSIM_15720 esterase\tK14731 mlhB; epsilon-lactone hydrolase [EC:3.1.1.83]" } ] }, { "name":"00907 Pinene, camphor and geraniol degradation [PATH:msim00907]", "children":[ { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_09610 oxidoreductase\tK13775 atuG; citronellol\/citronellal dehydrogenase" }, { "name":"MSIM_12380 short chain dehydrogenase\tK13775 atuG; citronellol\/citronellal dehydrogenase" }, { "name":"MSIM_07070 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_10890 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_05960 ltp1; lipid-transfer protein\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_12520 acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29240 fadA6; acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29330 fadA5; steroid 3-ketoacyl-CoA thiolase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_31960 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_37930 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" } ] }, { "name":"01052 Type I polyketide structures" }, { "name":"00522 Biosynthesis of 12-, 14- and 16-membered macrolides" }, { "name":"01051 Biosynthesis of ansamycins", "children":[ { "name":"MSIM_02300 tkt; transketolase\tK00615 E2.2.1.1; transketolase [EC:2.2.1.1]" } ] }, { "name":"01059 Biosynthesis of enediyne antibiotics [PATH:msim01059]", "children":[ { "name":"MSIM_45310 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase" } ] }, { "name":"01056 Biosynthesis of type II polyketide backbone" }, { "name":"01057 Biosynthesis of type II polyketide products" }, { "name":"00253 Tetracycline biosynthesis" }, { "name":"00523 Polyketide sugar unit biosynthesis [PATH:msim00523]", "children":[ { "name":"MSIM_19350 rmlA; glucose-1-phosphate thymidylyltransferase\tK00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]" }, { "name":"MSIM_11460 rfbB; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15310 rmlB1; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15320 rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase\tK01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]" }, { "name":"MSIM_36330 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase\tK01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]" }, { "name":"MSIM_13140 rmlD; NAD(P)-dependent oxidoreductase\tK00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]" }, { "name":"MSIM_01840 putative epimerase\/dehydratase\tK17947 wbiB; dTDP-L-rhamnose 4-epimerase [EC:5.1.3.25]" }, { "name":"MSIM_17130 galE3; UDP-glucose 4-epimerase\tK17947 wbiB; dTDP-L-rhamnose 4-epimerase [EC:5.1.3.25]" } ] }, { "name":"01054 Nonribosomal peptide structures" }, { "name":"01053 Biosynthesis of siderophore group nonribosomal peptides [PATH:msim01053]", "children":[ { "name":"MSIM_12280 menF; putative isochorismate synthase MenF\tK02361 entC; isochorismate synthase [EC:5.4.4.2]" }, { "name":"MSIM_05990 4'-phosphopantetheinyl transferase\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]" }, { "name":"MSIM_42480 mbtI; salicylate synthase\tK04781 mbtI; salicylate synthetase [EC:5.4.4.2 4.2.99.21]" }, { "name":"MSIM_42550 mbtA; 2,3-dihydroxybenzoate-AMP ligase\tK04787 mbtA; mycobactin salicyl-AMP ligase [EC:6.3.2.-]" }, { "name":"MSIM_42560 mbtB; phenyloxazoline synthase MbtB\tK04788 mbtB; mycobactin phenyloxazoline synthetase" }, { "name":"MSIM_22760 putative peptide synthetase MbtE\tK04789 mbtE; mycobactin peptide synthetase MbtE" }, { "name":"MSIM_42600 hypothetical protein\tK04789 mbtE; mycobactin peptide synthetase MbtE" }, { "name":"MSIM_22780 putative polyketide synthase MbtC\tK04790 mbtC; mycobactin polyketide synthetase MbtC" }, { "name":"MSIM_42580 polyketide synthase\tK04790 mbtC; mycobactin polyketide synthetase MbtC" }, { "name":"MSIM_22790 putative polyketide synthase MbtD\tK04791 mbtD; mycobactin polyketide synthetase MbtD" }, { "name":"MSIM_42590 mbtD; polyketide synthase\tK04791 mbtD; mycobactin polyketide synthetase MbtD" }, { "name":"MSIM_22750 putative peptide synthetase MbtF\tK04792 mbtF; mycobactin peptide synthetase MbtF" }, { "name":"MSIM_42610 non-ribosomal peptide synthetase\tK04792 mbtF; mycobactin peptide synthetase MbtF" }, { "name":"MSIM_42620 mbtG; L-lysine N6-monooxygenase MbtG\tK04793 mbtG; mycobactin lysine-N-oxygenase" } ] }, { "name":"01055 Biosynthesis of vancomycin group antibiotics [PATH:msim01055]", "children":[ { "name":"MSIM_11460 rfbB; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15310 rmlB1; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_05540 glycosyl transferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]" } ] } ] }, { "name":"09110 Biosynthesis of other secondary metabolites", "children":[ { "name":"00940 Phenylpropanoid biosynthesis" }, { "name":"00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis" }, { "name":"00941 Flavonoid biosynthesis" }, { "name":"00944 Flavone and flavonol biosynthesis" }, { "name":"00942 Anthocyanin biosynthesis" }, { "name":"00943 Isoflavonoid biosynthesis" }, { "name":"00946 Degradation of flavonoids [PATH:msim00946]", "children":[ { "name":"MSIM_21050 bglS; beta-glucosidase\tK05349 bglX; beta-glucosidase [EC:3.2.1.21]" } ] }, { "name":"00901 Indole alkaloid biosynthesis" }, { "name":"00403 Indole diterpene alkaloid biosynthesis" }, { "name":"00950 Isoquinoline alkaloid biosynthesis" }, { "name":"00960 Tropane, piperidine and pyridine alkaloid biosynthesis" }, { "name":"00996 Biosynthesis of various alkaloids" }, { "name":"00232 Caffeine metabolism", "children":[ { "name":"MSIM_29140 nat; arylamine N-acetyltransferase\tK00622 nat; arylamine N-acetyltransferase [EC:2.3.1.5]" } ] }, { "name":"00965 Betalain biosynthesis" }, { "name":"00966 Glucosinolate biosynthesis" }, { "name":"00402 Benzoxazinoid biosynthesis" }, { "name":"00311 Penicillin and cephalosporin biosynthesis [PATH:msim00311]", "children":[ { "name":"MSIM_40750 aao_1; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_50640 aao_2; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_05860 beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]" } ] }, { "name":"00332 Carbapenem biosynthesis [PATH:msim00332]", "children":[ { "name":"MSIM_41860 proB; glutamate 5-kinase\tK00931 proB; glutamate 5-kinase [EC:2.7.2.11]" }, { "name":"MSIM_42020 proA; gamma-glutamyl phosphate reductase\tK00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]" } ] }, { "name":"00261 Monobactam biosynthesis [PATH:msim00261]", "children":[ { "name":"MSIM_42630 mbtH; protein MbtH\tK05375 mbtH; MbtH protein" }, { "name":"MSIM_38360 adenylyl-sulfate kinase\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_39440 cysNC; bifunctional enzyme CysN\/CysC\tK00955 cysNC; bifunctional enzyme CysN\/CysC [EC:2.7.7.4 2.7.1.25]" }, { "name":"MSIM_38370 sulfate adenylyltransferase\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_39430 cysD; sulfate adenylyltransferase subunit 2\tK00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]" }, { "name":"MSIM_27380 ask; aspartokinase\tK00928 lysC; aspartate kinase [EC:2.7.2.4]" }, { "name":"MSIM_27390 asd; aspartate-semialdehyde dehydrogenase\tK00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]" }, { "name":"MSIM_03510 putative dihydrodipicolinate synthetase DapA\tK01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]" }, { "name":"MSIM_05450 dapA; 4-hydroxy-tetrahydrodipicolinate synthase\tK01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]" }, { "name":"MSIM_40380 hypothetical protein\tK01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]" }, { "name":"MSIM_05710 dapB_1; 4-hydroxy-tetrahydrodipicolinate reductase\tK00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]" }, { "name":"MSIM_05760 dapB_2; dihydrodipicolinate reductase\tK00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]" } ] }, { "name":"00331 Clavulanic acid biosynthesis" }, { "name":"00521 Streptomycin biosynthesis [PATH:msim00521]", "children":[ { "name":"MSIM_16360 sugar kinase\tK25026 glk; glucokinase [EC:2.7.1.2]" }, { "name":"MSIM_09910 pgmA; phosphoglucomutase, alpha-D-glucose phosphate-specific\tK01835 pgm; phosphoglucomutase [EC:5.4.2.2]" }, { "name":"MSIM_24360 hypothetical protein\tK01858 INO1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]" }, { "name":"MSIM_00960 impA; putative inositol 1-monophosphatase ImpA\tK01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]" }, { "name":"MSIM_04980 suhB; inositol-1-monophosphatase SuhB\tK01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]" }, { "name":"MSIM_24190 inositol monophosphatase\tK01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]" }, { "name":"MSIM_19350 rmlA; glucose-1-phosphate thymidylyltransferase\tK00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]" }, { "name":"MSIM_11460 rfbB; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15310 rmlB1; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15320 rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase\tK01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]" }, { "name":"MSIM_36330 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase\tK01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]" }, { "name":"MSIM_13140 rmlD; NAD(P)-dependent oxidoreductase\tK00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]" } ] }, { "name":"00524 Neomycin, kanamycin and gentamicin biosynthesis", "children":[ { "name":"MSIM_16360 sugar kinase\tK25026 glk; glucokinase [EC:2.7.1.2]" } ] }, { "name":"00525 Acarbose and validamycin biosynthesis [PATH:msim00525]", "children":[ { "name":"MSIM_19350 rmlA; glucose-1-phosphate thymidylyltransferase\tK00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]" }, { "name":"MSIM_11460 rfbB; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" }, { "name":"MSIM_15310 rmlB1; dTDP-glucose 4,6-dehydratase\tK01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]" } ] }, { "name":"00401 Novobiocin biosynthesis [PATH:msim00401]", "children":[ { "name":"MSIM_26550 tyrA; prephenate dehydrogenase\tK04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12]" }, { "name":"MSIM_01000 hisC; histidinol-phosphate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_15470 aspartate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_26310 pat; putative phenylalanine aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_45390 putative aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" } ] }, { "name":"00404 Staurosporine biosynthesis" }, { "name":"00405 Phenazine biosynthesis", "children":[ { "name":"MSIM_00890 trpE; anthranilate synthase component 1\tK01657 trpE; anthranilate synthase component I [EC:4.1.3.27]" } ] }, { "name":"00333 Prodigiosin biosynthesis", "children":[ { "name":"MSIM_16370 fabD2; malonyl CoA-ACP transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_45180 fabD; malonyl CoA-acyl carrier protein transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_12430 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_20250 fabG4; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_22950 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_31770 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34040 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34210 fabG_3; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34260 3-ketoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35190 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35590 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35600 hypothetical protein\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_40200 fabG2; putative oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" } ] }, { "name":"00254 Aflatoxin biosynthesis" }, { "name":"00975 Biosynthesis of various siderophores" }, { "name":"00998 Biosynthesis of various antibiotics", "children":[ { "name":"MSIM_40080 mbtL; acyl carrier protein MbtL\tK02078 acpP; acyl carrier protein" }, { "name":"MSIM_45170 acpM; meromycolate extension acyl carrier protein\tK02078 acpP; acyl carrier protein" } ] }, { "name":"00999 Biosynthesis of various plant secondary metabolites [PATH:msim00999]", "children":[ { "name":"MSIM_02860 metK; S-adenosylmethionine synthase\tK00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]" }, { "name":"MSIM_21050 bglS; beta-glucosidase\tK05349 bglX; beta-glucosidase [EC:3.2.1.21]" } ] }, { "name":"00997 Biosynthesis of various other secondary metabolites", "children":[ { "name":"MSIM_08600 polyprenyl synthetase\tK13787 idsA; geranylgeranyl diphosphate synthase, type I [EC:2.5.1.1 2.5.1.10 2.5.1.29]" }, { "name":"MSIM_46150 idsA2; geranylgeranyl pyrophosphate synthase\tK13787 idsA; geranylgeranyl diphosphate synthase, type I [EC:2.5.1.1 2.5.1.10 2.5.1.29]" } ] } ] }, { "name":"09111 Xenobiotics biodegradation and metabolism", "children":[ { "name":"00362 Benzoate degradation [PATH:msim00362]", "children":[ { "name":"MSIM_09790 pcaD; 3-oxoadipate enol-lactonase\tK01055 pcaD; 3-oxoadipate enol-lactonase [EC:3.1.1.24]" }, { "name":"MSIM_20630 putative hydrolase, alpha\/beta fold protein\tK01055 pcaD; 3-oxoadipate enol-lactonase [EC:3.1.1.24]" }, { "name":"MSIM_05960 ltp1; lipid-transfer protein\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_12520 acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29240 fadA6; acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29330 fadA5; steroid 3-ketoacyl-CoA thiolase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_31960 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_37930 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29430 hsaE; hydratase\tK02554 mhpD; 2-keto-4-pentenoate hydratase [EC:4.2.1.80]" }, { "name":"MSIM_29450 bphI-2; 4-hydroxy-2-oxovalerate aldolase 2\tK01666 mhpE; 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]" }, { "name":"MSIM_29440 mhpF; acetaldehyde dehydrogenase 2\tK04073 mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10]" }, { "name":"MSIM_44860 6-chlorohydroxyquinol-1,2-dioxygenase\tK04098 chqB; hydroxyquinol 1,2-dioxygenase [EC:1.13.11.37]" }, { "name":"MSIM_30280 pcaC_1; 4-carboxymuconolactone decarboxylase\tK01607 pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]" }, { "name":"MSIM_32190 hypothetical protein\tK01607 pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]" }, { "name":"MSIM_51260 reductase\tK00529 hcaD; 3-phenylpropionate\/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]" }, { "name":"MSIM_26990 3-oxoacyl-ACP reductase\tK07535 badH; 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-]" }, { "name":"MSIM_32280 3-oxoacyl-ACP reductase\tK07535 badH; 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-]" }, { "name":"MSIM_42190 acyl-CoA dehydrogenase\tK04118 pimC; pimeloyl-CoA dehydrogenase large subunit [EC:1.3.1.62]" }, { "name":"MSIM_42180 acyl-CoA dehydrogenase\tK28556 pimD; pimeloyl-CoA dehydrogenase small subunit [EC:1.3.1.62]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" }, { "name":"MSIM_18720 fadE7; acyl-CoA dehydrogenase\tK00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_12460 putative dehydrogenase (3-hydroxybutyryl-CoA dehydrogenase FadB?)\tK00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]" }, { "name":"MSIM_17830 fadB2; 3-hydroxybutyryl-CoA dehydrogenase\tK00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" } ] }, { "name":"00627 Aminobenzoate degradation [PATH:msim00627]", "children":[ { "name":"MSIM_25530 ethA; FAD-containing monooxygenase EthA\tK10215 ethA; monooxygenase [EC:1.14.13.-]" }, { "name":"MSIM_46440 nthA; nitrile hydratase subunit alpha\tK01721 nthA; nitrile hydratase subunit alpha [EC:4.2.1.84]" }, { "name":"MSIM_46430 nitrile hydratase\tK20807 nthB; nitrile hydratase subunit beta [EC:4.2.1.84]" }, { "name":"MSIM_06940 amiC; putative amidase AmiC\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_39080 amiB2; putative amidase AmiB2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_42810 amiA2; putative amidase AmiA2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_20980 nitrilase\tK01501 E3.5.5.1; nitrilase [EC:3.5.5.1]" }, { "name":"MSIM_07610 acyP; acylphosphatase\tK01512 acyP; acylphosphatase [EC:3.6.1.7]" }, { "name":"MSIM_31180 mdlC_1; benzoylformate decarboxylase\tK01576 mdlC; benzoylformate decarboxylase [EC:4.1.1.7]" }, { "name":"MSIM_40580 benzoylformate decarboxylase\tK01576 mdlC; benzoylformate decarboxylase [EC:4.1.1.7]" }, { "name":"MSIM_46620 mdlC_2; benzoylformate decarboxylase\tK01576 mdlC; benzoylformate decarboxylase [EC:4.1.1.7]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" } ] }, { "name":"00364 Fluorobenzoate degradation [PATH:msim00364]", "children":[ { "name":"MSIM_36940 carboxymethylenebutenolidase\tK01061 clcD; carboxymethylenebutenolidase [EC:3.1.1.45]" }, { "name":"MSIM_47630 hypothetical protein\tK01061 clcD; carboxymethylenebutenolidase [EC:3.1.1.45]" }, { "name":"MSIM_46440 nthA; nitrile hydratase subunit alpha\tK01721 nthA; nitrile hydratase subunit alpha [EC:4.2.1.84]" }, { "name":"MSIM_46430 nitrile hydratase\tK20807 nthB; nitrile hydratase subunit beta [EC:4.2.1.84]" } ] }, { "name":"00625 Chloroalkane and chloroalkene degradation [PATH:msim00625]", "children":[ { "name":"MSIM_26840 haloalkane dehalogenase\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_43640 dhmA2_1; haloalkane dehalogenase 2\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_44440 dhmA1; haloalkane dehalogenase 1\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_48750 dhmA; haloalkane dehalogenase\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_48890 dhmA2_2; haloalkane dehalogenase 2\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_48960 dhmA2_3; haloalkane dehalogenase 2\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_09660 alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_51380 adhA; alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_30180 adhB; alcohol dehydrogenase B\tK00121 frmA; S-(hydroxymethyl)glutathione dehydrogenase \/ alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]" }, { "name":"MSIM_10390 putative aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_20520 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_21740 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_22290 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_30250 aldA_1; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35080 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_35440 aldA_2; aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_37920 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_38480 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40940 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_43510 aldehyde dehydrogenase\tK00128 ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]" }, { "name":"MSIM_40490 alpha\/beta hydrolase\tK01561 dehH; haloacetate dehalogenase [EC:3.8.1.3]" }, { "name":"MSIM_30670 dehII; haloacid dehalogenase\tK01560 E3.8.1.2; 2-haloacid dehalogenase [EC:3.8.1.2]" }, { "name":"MSIM_44950 putative HAD-superfamily hydrolase YfnB\tK01560 E3.8.1.2; 2-haloacid dehalogenase [EC:3.8.1.2]" } ] }, { "name":"00361 Chlorocyclohexane and chlorobenzene degradation [PATH:msim00361]", "children":[ { "name":"MSIM_26840 haloalkane dehalogenase\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_43640 dhmA2_1; haloalkane dehalogenase 2\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_44440 dhmA1; haloalkane dehalogenase 1\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_48750 dhmA; haloalkane dehalogenase\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_48890 dhmA2_2; haloalkane dehalogenase 2\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_48960 dhmA2_3; haloalkane dehalogenase 2\tK01563 dhaA; haloalkane dehalogenase [EC:3.8.1.5]" }, { "name":"MSIM_36940 carboxymethylenebutenolidase\tK01061 clcD; carboxymethylenebutenolidase [EC:3.1.1.45]" }, { "name":"MSIM_47630 hypothetical protein\tK01061 clcD; carboxymethylenebutenolidase [EC:3.1.1.45]" }, { "name":"MSIM_44860 6-chlorohydroxyquinol-1,2-dioxygenase\tK04098 chqB; hydroxyquinol 1,2-dioxygenase [EC:1.13.11.37]" }, { "name":"MSIM_30670 dehII; haloacid dehalogenase\tK01560 E3.8.1.2; 2-haloacid dehalogenase [EC:3.8.1.2]" }, { "name":"MSIM_44950 putative HAD-superfamily hydrolase YfnB\tK01560 E3.8.1.2; 2-haloacid dehalogenase [EC:3.8.1.2]" }, { "name":"MSIM_40490 alpha\/beta hydrolase\tK01561 dehH; haloacetate dehalogenase [EC:3.8.1.3]" } ] }, { "name":"00623 Toluene degradation [PATH:msim00623]", "children":[ { "name":"MSIM_36940 carboxymethylenebutenolidase\tK01061 clcD; carboxymethylenebutenolidase [EC:3.1.1.45]" }, { "name":"MSIM_47630 hypothetical protein\tK01061 clcD; carboxymethylenebutenolidase [EC:3.1.1.45]" } ] }, { "name":"00622 Xylene degradation [PATH:msim00622]", "children":[ { "name":"MSIM_50150 aldehyde dehydrogenase\tK10618 cymC; p-cumic aldehyde dehydrogenase" }, { "name":"MSIM_29430 hsaE; hydratase\tK02554 mhpD; 2-keto-4-pentenoate hydratase [EC:4.2.1.80]" }, { "name":"MSIM_29450 bphI-2; 4-hydroxy-2-oxovalerate aldolase 2\tK01666 mhpE; 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]" }, { "name":"MSIM_29440 mhpF; acetaldehyde dehydrogenase 2\tK04073 mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10]" } ] }, { "name":"00633 Nitrotoluene degradation [PATH:msim00633]", "children":[ { "name":"MSIM_53060 putative NADH-dependent flavin oxidoreductase\tK10680 nemA; N-ethylmaleimide reductase [EC:1.-.-.-]" }, { "name":"MSIM_06530 hydrogenase\tK06281 hyaB; hydrogenase large subunit [EC:1.12.99.6]" }, { "name":"MSIM_06520 hydrogenase expression protein HypE\tK06282 hyaA; hydrogenase small subunit [EC:1.12.99.6]" }, { "name":"MSIM_29140 nat; arylamine N-acetyltransferase\tK00622 nat; arylamine N-acetyltransferase [EC:2.3.1.5]" } ] }, { "name":"00642 Ethylbenzene degradation", "children":[ { "name":"MSIM_05960 ltp1; lipid-transfer protein\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_12520 acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29240 fadA6; acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29330 fadA5; steroid 3-ketoacyl-CoA thiolase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_31960 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_37930 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" } ] }, { "name":"00643 Styrene degradation [PATH:msim00643]", "children":[ { "name":"MSIM_43950 aldehyde dehydrogenase\tK00146 feaB; phenylacetaldehyde dehydrogenase [EC:1.2.1.39]" }, { "name":"MSIM_10860 hmgA; hypothetical protein\tK00451 HGD; homogentisate 1,2-dioxygenase [EC:1.13.11.5]" }, { "name":"MSIM_46440 nthA; nitrile hydratase subunit alpha\tK01721 nthA; nitrile hydratase subunit alpha [EC:4.2.1.84]" }, { "name":"MSIM_46430 nitrile hydratase\tK20807 nthB; nitrile hydratase subunit beta [EC:4.2.1.84]" }, { "name":"MSIM_06940 amiC; putative amidase AmiC\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_39080 amiB2; putative amidase AmiB2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_42810 amiA2; putative amidase AmiA2\tK01426 E3.5.1.4; amidase [EC:3.5.1.4]" }, { "name":"MSIM_20980 nitrilase\tK01501 E3.5.5.1; nitrilase [EC:3.5.5.1]" } ] }, { "name":"00791 Atrazine degradation", "children":[ { "name":"MSIM_51620 ureC; urease subunit alpha\tK01428 ureC; urease subunit alpha [EC:3.5.1.5]" }, { "name":"MSIM_51630 ureB; urease subunit beta\tK01429 ureB; urease subunit beta [EC:3.5.1.5]" }, { "name":"MSIM_51640 ureA; urease subunit gamma\tK01430 ureA; urease subunit gamma [EC:3.5.1.5]" } ] }, { "name":"00930 Caprolactam degradation [PATH:msim00930]", "children":[ { "name":"MSIM_12980 alkB; alkane 1-monooxygenase AlkB\tK00496 alkB1_2; alkane 1-monooxygenase [EC:1.14.15.3]" }, { "name":"MSIM_22330 monooxygenase\tK03379 chnB; cyclohexanone monooxygenase [EC:1.14.13.22]" }, { "name":"MSIM_34020 hypothetical protein\tK01053 gnl; gluconolactonase [EC:3.1.1.17]" }, { "name":"MSIM_15720 esterase\tK14731 mlhB; epsilon-lactone hydrolase [EC:3.1.1.83]" }, { "name":"MSIM_40190 acyl-CoA dehydrogenase\tK06446 DCAA; acyl-CoA dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_02110 echA12; putative enoyl-CoA hydratase echA12\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_08820 echA17; putative enoyl-CoA hydratase echA17\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_37060 echA8; putative enoyl-CoA hydratase echA8\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_41350 echA14; putative enoyl-CoA hydratase echA14\tK01692 paaF; enoyl-CoA hydratase [EC:4.2.1.17]" }, { "name":"MSIM_32650 fadB; fatty oxidation protein FadB\tK01782 fadJ; 3-hydroxyacyl-CoA dehydrogenase \/ enoyl-CoA hydratase \/ 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]" } ] }, { "name":"00363 Bisphenol degradation", "children":[ { "name":"MSIM_50750 monooxygenase\tK14520 hapE; 4-hydroxyacetophenone monooxygenase [EC:1.14.13.84]" } ] }, { "name":"00621 Dioxin degradation [PATH:msim00621]", "children":[ { "name":"MSIM_29430 hsaE; hydratase\tK02554 mhpD; 2-keto-4-pentenoate hydratase [EC:4.2.1.80]" }, { "name":"MSIM_29450 bphI-2; 4-hydroxy-2-oxovalerate aldolase 2\tK01666 mhpE; 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]" }, { "name":"MSIM_29440 mhpF; acetaldehyde dehydrogenase 2\tK04073 mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10]" } ] }, { "name":"00626 Naphthalene degradation [PATH:msim00626]", "children":[ { "name":"MSIM_09660 alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_51380 adhA; alcohol dehydrogenase\tK13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]" }, { "name":"MSIM_30180 adhB; alcohol dehydrogenase B\tK00121 frmA; S-(hydroxymethyl)glutathione dehydrogenase \/ alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]" } ] }, { "name":"00624 Polycyclic aromatic hydrocarbon degradation" }, { "name":"00365 Furfural degradation" }, { "name":"00984 Steroid degradation [PATH:msim00984]", "children":[ { "name":"MSIM_14610 choD; cholesterol oxidase\tK03333 choD; cholesterol oxidase [EC:1.1.3.6]" }, { "name":"MSIM_37390 3 beta-hydroxysteroid dehydrogenase\/Delta 5-->4-isomerase\tK16045 hsd; 3beta-hydroxy-Delta5-steroid dehydrogenase \/ steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]" }, { "name":"MSIM_21650 cytochrome P450\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_29340 cytochrome P450 steroid C27-monooxygenase\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_43540 cytochrome P450\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_50820 linalool 8-monooxygenase\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_29590 cyp142; putative cytochrome P450 142\tK16046 CYP142; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28]" }, { "name":"MSIM_48400 cytochrome P450\tK16046 CYP142; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28]" }, { "name":"MSIM_04310 acyl-CoA synthetase\tK18688 fadD19; 3-oxocholest-4-en-26-oate---CoA ligase [EC:6.2.1.42]" }, { "name":"MSIM_29610 fadD19; long-chain-fatty-acid--CoA\/3-oxocholest-4-en-26-o ate--CoA ligase\tK18688 fadD19; 3-oxocholest-4-en-26-oate---CoA ligase [EC:6.2.1.42]" }, { "name":"MSIM_40420 acyl-CoA synthetase\tK18688 fadD19; 3-oxocholest-4-en-26-oate---CoA ligase [EC:6.2.1.42]" }, { "name":"MSIM_40500 acyl-CoA synthetase\tK18688 fadD19; 3-oxocholest-4-en-26-oate---CoA ligase [EC:6.2.1.42]" }, { "name":"MSIM_32600 far; fatty-acid-CoA racemase\tK01796 AMACR; alpha-methylacyl-CoA racemase [EC:5.1.99.4]" }, { "name":"MSIM_38010 mcr; alpha-methylacyl-CoA racemase\tK01796 AMACR; alpha-methylacyl-CoA racemase [EC:5.1.99.4]" }, { "name":"MSIM_29690 fadE26; acyl-CoA dehydrogenase\tK22818 fadE26; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-]" }, { "name":"MSIM_35420 acyl-CoA dehydrogenase\tK22818 fadE26; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-]" }, { "name":"MSIM_29680 fadE27; acyl-CoA dehydrogenase FadE27\tK22819 fadE27; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase beta subunit [EC:1.3.99.-]" }, { "name":"MSIM_35390 putative acyl-CoA dehydrogenase\tK22819 fadE27; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase beta subunit [EC:1.3.99.-]" }, { "name":"MSIM_05960 ltp1; lipid-transfer protein\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_12520 acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29240 fadA6; acetyl-CoA acetyltransferase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29330 fadA5; steroid 3-ketoacyl-CoA thiolase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_31960 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_37930 acyl-CoA dehydrogenase\tK00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16]" }, { "name":"MSIM_29040 fadE34; acyl-CoA dehydrogenase\tK22820 fadE34; 3-oxochol-4-en-24-oyl-CoA dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_29410 dehydrogenase\tK28218 chsH3; 3-oxochol-4,22-dien-24-oyl-CoA hydratase (S-form) [EC:4.2.1.-]" }, { "name":"MSIM_29710 3-oxoacyl-ACP reductase\tK28219 chsB1; (22S)-hydroxy-3-oxochol-4-en-24-oyl-CoA dehydrogenase [EC:1.1.1.-]" }, { "name":"MSIM_29350 fadE28; acyl-CoA dehydrogenase\tK22821 fadE28; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-]" }, { "name":"MSIM_29360 fadE29; acyl-CoA dehydrogenase FadE29\tK22822 fadE29; 3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit [EC:1.3.99.-]" }, { "name":"MSIM_29370 hypothetical protein\tK25621 chsH2; 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase alpha subunit [EC:4.2.1.-]" }, { "name":"MSIM_29380 hypothetical protein\tK25622 chsH1; 3-oxo-4,17-pregnadiene-20-carboxyl-CoA hydratase beta subunit [EC:4.2.1.-]" }, { "name":"MSIM_29390 ltp2; lipid-transfer protein\tK25623 ltp2; 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA lyase [EC:4.1.3.-]" }, { "name":"MSIM_29530 hypothetical protein\tK01822 ksi; steroid Delta-isomerase [EC:5.3.3.1]" }, { "name":"MSIM_30160 hypothetical protein\tK01822 ksi; steroid Delta-isomerase [EC:5.3.3.1]" }, { "name":"MSIM_39510 hypothetical protein\tK01822 ksi; steroid Delta-isomerase [EC:5.3.3.1]" }, { "name":"MSIM_13580 3-ketosteroid-delta-1-dehydrogenase\tK05898 kstD; 3-oxosteroid 1-dehydrogenase [EC:1.3.99.4]" }, { "name":"MSIM_29420 3-oxosteroid 1-dehydrogenase\tK05898 kstD; 3-oxosteroid 1-dehydrogenase [EC:1.3.99.4]" }, { "name":"MSIM_31540 3-ketosteroid-delta-1-dehydrogenase\tK05898 kstD; 3-oxosteroid 1-dehydrogenase [EC:1.3.99.4]" }, { "name":"MSIM_52410 3-oxosteroid 1-dehydrogenase\tK05898 kstD; 3-oxosteroid 1-dehydrogenase [EC:1.3.99.4]" }, { "name":"MSIM_29510 3-ketosteroid-9-alpha-monooxygenase oxygenase subunit\tK15982 kshA; 3-ketosteroid 9alpha-monooxygenase subunit A [EC:1.14.15.30]" }, { "name":"MSIM_53050 3-ketosteroid-9-alpha-hydroxylase oxygenase subunit\tK15982 kshA; 3-ketosteroid 9alpha-monooxygenase subunit A [EC:1.14.15.30]" }, { "name":"MSIM_29080 hmp; 3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component\tK15983 kshB; 3-ketosteroid 9alpha-monooxygenase subunit B [EC:1.14.15.30]" }, { "name":"MSIM_29090 oxidoreductase\tK16047 hsaA; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12]" }, { "name":"MSIM_53010 hydroxylase\tK16047 hsaA; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase [EC:1.14.14.12]" }, { "name":"MSIM_29120 oxidoreductase\tK16048 hsaB; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase reductase component [EC:1.5.1.-]" }, { "name":"MSIM_29110 hsaC; iron-dependent extradiol dioxygenase\tK16049 hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25]" }, { "name":"MSIM_53020 biphenyl-2,3-diol 1,2-dioxygenase\tK16049 hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25]" }, { "name":"MSIM_29100 hsaD; 4,5:9,10-diseco-3-hydroxy-5,9, 17-trioxoandrosta-1 (10),2-diene-4-oate hydrolase\tK16050 hsaD; 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase [EC:3.7.1.17]" }, { "name":"MSIM_29200 fadD3; 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase\tK18687 fadD3; HIP---CoA ligase [EC:6.2.1.41]" }, { "name":"MSIM_32550 fatty acid--CoA ligase\tK18687 fadD3; HIP---CoA ligase [EC:6.2.1.41]" }, { "name":"MSIM_29220 oxidoreductase\tK28220 scdG; hydroxylacyl dehydrogenase [EC:1.1.-.-]" }, { "name":"MSIM_29170 fadE33; acyl-CoA dehydrogenase\tK28221 scdC1; 5OH-HIP-CoA dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_29210 fadE30; acyl-CoA dehydrogenase\tK28222 scdC2; 5OH-HIP-CoA dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_22070 putative enoyl-CoA hydratase 1\tK28224 scdD; enoyl-CoA hydratase [EC:4.2.1.-]" }, { "name":"MSIM_35460 putative enoyl-CoA hydratase 1\tK28224 scdD; enoyl-CoA hydratase [EC:4.2.1.-]" }, { "name":"MSIM_29300 short-chain dehydrogenase\tK28225 scdE; 3-hydroxyl acyl-CoA dehydrogenase [EC:1.1.-.-]" }, { "name":"MSIM_29250 oxidoreductase\tK28226 scdK; acyl-CoA dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_29280 enoyl-CoA hydratase\tK28227 scdY; HIEC-CoA hydrolase [EC:4.1.-.-]" }, { "name":"MSIM_29270 CoA-transferase\tK28228 scdL1; COCHEA-CoA hydrolase alpha subunit [EC:4.1.-.-]" }, { "name":"MSIM_29260 CoA-transferase\tK28229 scdL2; COCHEA-CoA hydrolase beta subunit [EC:4.1.-.-]" }, { "name":"MSIM_29190 fadE31; acyl-CoA dehydrogenase\tK28230 scdM1; acyl-CoA dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_29180 fadE32; acyl-CoA dehydrogenase\tK28231 scdM2; acyl-CoA dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_29850 enoyl-CoA hydratase\tK28232 scdN; enoyl-CoA hydratase [EC:4.2.1.-]" }, { "name":"MSIM_35840 echA13; putative enoyl-CoA hydratase EchA13\tK28232 scdN; enoyl-CoA hydratase [EC:4.2.1.-]" } ] }, { "name":"00980 Metabolism of xenobiotics by cytochrome P450" }, { "name":"00982 Drug metabolism - cytochrome P450" }, { "name":"00983 Drug metabolism - other enzymes [PATH:msim00983]", "children":[ { "name":"MSIM_28400 hpt; hypoxanthine-guanine phosphoribosyltransferase\tK00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]" }, { "name":"MSIM_14620 guaB3; putative oxidoreductase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]" }, { "name":"MSIM_14630 guaB; inosine-5'-monophosphate dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]" }, { "name":"MSIM_14540 guaA; GMP synthase [glutamine-hydrolyzing]\tK01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]" }, { "name":"MSIM_40050 rdgB; non-canonical purine NTP pyrophosphatase\tK01519 rdgB; XTP\/dITP diphosphohydrolase [EC:3.6.1.66]" }, { "name":"MSIM_13990 cdd; cytidine deaminase\tK01489 cdd; cytidine deaminase [EC:3.5.4.5]" }, { "name":"MSIM_13980 deoA; thymidine phosphorylase\tK00758 deoA; thymidine phosphorylase [EC:2.4.2.4]" }, { "name":"MSIM_41810 ndkA; nucleoside diphosphate kinase\tK00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]" }, { "name":"MSIM_04940 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]" }, { "name":"MSIM_49980 katG2; catalase-peroxidase 2\tK03782 katG; catalase-peroxidase [EC:1.11.1.21]" }, { "name":"MSIM_29140 nat; arylamine N-acetyltransferase\tK00622 nat; arylamine N-acetyltransferase [EC:2.3.1.5]" } ] } ] }, { "name":"09112 Not included in regular maps", "children":[ { "name":"09113 Global maps only" } ] } ] }, { "name":"09120 Genetic Information Processing", "children":[ { "name":"09121 Transcription", "children":[ { "name":"03020 RNA polymerase [PATH:msim03020]", "children":[ { "name":"MSIM_16300 rpoB; DNA-directed RNA polymerase subunit beta\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]" }, { "name":"MSIM_16290 rpoC; DNA-directed RNA polymerase subunit beta'\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]" }, { "name":"MSIM_15220 rpoA; DNA-directed RNA polymerase subunit alpha\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]" }, { "name":"MSIM_02880 rpoZ; DNA-directed RNA polymerase subunit omega\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]" } ] }, { "name":"03022 Basal transcription factors", "children":[ { "name":"MSIM_32790 helicase\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]" } ] }, { "name":"03040 Spliceosome" } ] }, { "name":"09122 Translation", "children":[ { "name":"03010 Ribosome [PATH:msim03010]", "children":[ { "name":"MSIM_r00020 23S ribosomal RNA\tK01980 23SrRNA; 23S ribosomal RNA" }, { "name":"MSIM_r00030 5S ribosomal RNA\tK01985 5SrRNA; 5S ribosomal RNA" }, { "name":"MSIM_00660 rpsA; 30S ribosomal protein S1\tK02945 RP-S1; small subunit ribosomal protein S1" }, { "name":"MSIM_06960 rpsB; 30S ribosomal protein S2\tK02967 RP-S2; small subunit ribosomal protein S2" }, { "name":"MSIM_15920 rpsC; 30S ribosomal protein S3\tK02982 RP-S3; small subunit ribosomal protein S3" }, { "name":"MSIM_15230 rpsD; 30S ribosomal protein S4\tK02986 RP-S4; small subunit ribosomal protein S4" }, { "name":"MSIM_15750 rpsE; 30S ribosomal protein S5\tK02988 RP-S5; small subunit ribosomal protein S5" }, { "name":"MSIM_24170 rpsF; 30S ribosomal protein S6\tK02990 RP-S6; small subunit ribosomal protein S6" }, { "name":"MSIM_16190 rpsG; 30S ribosomal protein S7\tK02992 RP-S7; small subunit ribosomal protein S7" }, { "name":"MSIM_15780 rpsH; 30S ribosomal protein S8\tK02994 RP-S8; small subunit ribosomal protein S8" }, { "name":"MSIM_15070 rpsI; 30S ribosomal protein S9\tK02996 RP-S9; small subunit ribosomal protein S9" }, { "name":"MSIM_15990 rpsJ; 30S ribosomal protein S10\tK02946 RP-S10; small subunit ribosomal protein S10" }, { "name":"MSIM_15240 rpsK; 30S ribosomal protein S11\tK02948 RP-S11; small subunit ribosomal protein S11" }, { "name":"MSIM_16200 rpsL; 30S ribosomal protein S12\tK02950 RP-S12; small subunit ribosomal protein S12" }, { "name":"MSIM_15250 rpsM; 30S ribosomal protein S13\tK02952 RP-S13; small subunit ribosomal protein S13" }, { "name":"MSIM_15790 rpsZ; 30S ribosomal protein S14 type Z\tK02954 RP-S14; small subunit ribosomal protein S14" }, { "name":"MSIM_22520 rpsN; 30S ribosomal protein S14\tK02954 RP-S14; small subunit ribosomal protein S14" }, { "name":"MSIM_05900 rpsO; 30S ribosomal protein S15\tK02956 RP-S15; small subunit ribosomal protein S15" }, { "name":"MSIM_07400 rpsP; 30S ribosomal protein S16\tK02959 RP-S16; small subunit ribosomal protein S16" }, { "name":"MSIM_15890 rpsQ; 30S ribosomal protein S17\tK02961 RP-S17; small subunit ribosomal protein S17" }, { "name":"MSIM_22530 rpsR2; 30S ribosomal protein S18 2\tK02963 RP-S18; small subunit ribosomal protein S18" }, { "name":"MSIM_24150 rpsR; 30S ribosomal protein S18\tK02963 RP-S18; small subunit ribosomal protein S18" }, { "name":"MSIM_15940 rpsS; 30S ribosomal protein S19\tK02965 RP-S19; small subunit ribosomal protein S19" }, { "name":"MSIM_42230 rpsT; 30S ribosomal protein S20\tK02968 RP-S20; small subunit ribosomal protein S20" }, { "name":"MSIM_16490 rplA; 50S ribosomal protein L1\tK02863 RP-L1; large subunit ribosomal protein L1" }, { "name":"MSIM_15950 rplB; 50S ribosomal protein L2\tK02886 RP-L2; large subunit ribosomal protein L2" }, { "name":"MSIM_15980 rplC; 50S ribosomal protein L3\tK02906 RP-L3; large subunit ribosomal protein L3" }, { "name":"MSIM_15970 rplD; 50S ribosomal protein L4\tK02926 RP-L4; large subunit ribosomal protein L4" }, { "name":"MSIM_15800 rplE; 50S ribosomal protein L5\tK02931 RP-L5; large subunit ribosomal protein L5" }, { "name":"MSIM_15770 rplF; 50S ribosomal protein L6\tK02933 RP-L6; large subunit ribosomal protein L6" }, { "name":"MSIM_24140 rplI; 50S ribosomal protein L9\tK02939 RP-L9; large subunit ribosomal protein L9" }, { "name":"MSIM_16350 rplJ; 50S ribosomal protein L10\tK02864 RP-L10; large subunit ribosomal protein L10" }, { "name":"MSIM_16500 rplK; 50S ribosomal protein L11\tK02867 RP-L11; large subunit ribosomal protein L11" }, { "name":"MSIM_16340 rplL; 50S ribosomal protein L7\/L12\tK02935 RP-L7; large subunit ribosomal protein L7\/L12" }, { "name":"MSIM_15080 rplM; 50S ribosomal protein L13\tK02871 RP-L13; large subunit ribosomal protein L13" }, { "name":"MSIM_15820 rplN; 50S ribosomal protein L14\tK02874 RP-L14; large subunit ribosomal protein L14" }, { "name":"MSIM_15730 rplO; 50S ribosomal protein L15\tK02876 RP-L15; large subunit ribosomal protein L15" }, { "name":"MSIM_15910 rplP; 50S ribosomal protein L16\tK02878 RP-L16; large subunit ribosomal protein L16" }, { "name":"MSIM_15210 hypothetical protein\tK02879 RP-L17; large subunit ribosomal protein L17" }, { "name":"MSIM_15760 rplR; 50S ribosomal protein L18\tK02881 RP-L18; large subunit ribosomal protein L18" }, { "name":"MSIM_07350 rplS; 50S ribosomal protein L19\tK02884 RP-L19; large subunit ribosomal protein L19" }, { "name":"MSIM_00350 rplT; 50S ribosomal protein L20\tK02887 RP-L20; large subunit ribosomal protein L20" }, { "name":"MSIM_41830 rplU; 50S ribosomal protein L21\tK02888 RP-L21; large subunit ribosomal protein L21" }, { "name":"MSIM_15930 rplV; 50S ribosomal protein L22\tK02890 RP-L22; large subunit ribosomal protein L22" }, { "name":"MSIM_15960 rplW; 50S ribosomal protein L23\tK02892 RP-L23; large subunit ribosomal protein L23" }, { "name":"MSIM_15810 rplX; 50S ribosomal protein L24\tK02895 RP-L24; large subunit ribosomal protein L24" }, { "name":"MSIM_36470 rplY; 50S ribosomal protein L25\tK02897 RP-L25; large subunit ribosomal protein L25" }, { "name":"MSIM_41840 rpmA; 50S ribosomal protein L27\tK02899 RP-L27; large subunit ribosomal protein L27" }, { "name":"MSIM_08050 50S ribosomal protein L28\tK02902 RP-L28; large subunit ribosomal protein L28" }, { "name":"MSIM_22500 rpmB2; 50S ribosomal protein L28-2\tK02902 RP-L28; large subunit ribosomal protein L28" }, { "name":"MSIM_15900 rpmC; 50S ribosomal protein L29\tK02904 RP-L29; large subunit ribosomal protein L29" }, { "name":"MSIM_15740 rpmD; 50S ribosomal protein L30\tK02907 RP-L30; large subunit ribosomal protein L30" }, { "name":"MSIM_39650 rpmE; 50S ribosomal protein L31\tK02909 RP-L31; large subunit ribosomal protein L31" }, { "name":"MSIM_34910 rpmF; 50S ribosomal protein L32\tK02911 RP-L32; large subunit ribosomal protein L32" }, { "name":"MSIM_16560 rpmG2; 50S ribosomal protein L33 2\tK02913 RP-L33; large subunit ribosomal protein L33" }, { "name":"MSIM_22510 rpmG1; 50S ribosomal protein L33 1\tK02913 RP-L33; large subunit ribosomal protein L33" }, { "name":"MSIM_25110 rpmH; 50S ribosomal protein L34\tK02914 RP-L34; large subunit ribosomal protein L34" }, { "name":"MSIM_00360 rpmI; 50S ribosomal protein L35\tK02916 RP-L35; large subunit ribosomal protein L35" } ] }, { "name":"00970 Aminoacyl-tRNA biosynthesis [PATH:msim00970]", "children":[ { "name":"MSIM_t00090 tRNA-Ala\tK14218 tRNA-Ala; tRNA Ala" }, { "name":"MSIM_t00200 tRNA-Ala\tK14218 tRNA-Ala; tRNA Ala" }, { "name":"MSIM_t00350 tRNA-Ala\tK14218 tRNA-Ala; tRNA Ala" }, { "name":"MSIM_t00240 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00340 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00390 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00430 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00470 tRNA-Asn\tK14220 tRNA-Asn; tRNA Asn" }, { "name":"MSIM_t00320 tRNA-Asp\tK14221 tRNA-Asp; tRNA Asp" }, { "name":"MSIM_t00040 tRNA-Cys\tK14222 tRNA-Cys; tRNA Cys" }, { "name":"MSIM_t00490 tRNA-Cys\tK14222 tRNA-Cys; tRNA Cys" }, { "name":"MSIM_t00070 tRNA-Gln\tK14223 tRNA-Gln; tRNA Gln" }, { "name":"MSIM_t00360 tRNA-Gln\tK14223 tRNA-Gln; tRNA Gln" }, { "name":"MSIM_t00060 tRNA-Glu\tK14224 tRNA-Glu; tRNA Glu" }, { "name":"MSIM_t00310 tRNA-Glu\tK14224 tRNA-Glu; tRNA Glu" }, { "name":"MSIM_t00030 tRNA-Gly\tK14225 tRNA-Gly; tRNA Gly" }, { "name":"MSIM_t00170 tRNA-Gly\tK14225 tRNA-Gly; tRNA Gly" }, { "name":"MSIM_t00450 tRNA-Gly\tK14225 tRNA-Gly; tRNA Gly" }, { "name":"MSIM_t00420 tRNA-His\tK14226 tRNA-His; tRNA His" }, { "name":"MSIM_t00210 tRNA-Ile\tK14227 tRNA-Ile; tRNA Ile" }, { "name":"MSIM_t00010 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00190 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00370 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00400 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00510 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00300 tRNA-Lys\tK14229 tRNA-Lys; tRNA Lys" }, { "name":"MSIM_t00410 tRNA-Lys\tK14229 tRNA-Lys; tRNA Lys" }, { "name":"MSIM_t00100 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00130 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00480 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00330 tRNA-Phe\tK14231 tRNA-Phe; tRNA Phe" }, { "name":"MSIM_t00270 tRNA-Pro\tK14232 tRNA-Pro; tRNA Pro" }, { "name":"MSIM_t00460 tRNA-Pro\tK14232 tRNA-Pro; tRNA Pro" }, { "name":"MSIM_t00520 tRNA-Pro\tK14232 tRNA-Pro; tRNA Pro" }, { "name":"MSIM_t00220 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00230 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00250 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00260 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00140 tRNA-Thr\tK14234 tRNA-Thr; tRNA Thr" }, { "name":"MSIM_t00280 tRNA-Thr\tK14234 tRNA-Thr; tRNA Thr" }, { "name":"MSIM_t00290 tRNA-Thr\tK14234 tRNA-Thr; tRNA Thr" }, { "name":"MSIM_t00120 tRNA-Trp\tK14235 tRNA-Trp; tRNA Trp" }, { "name":"MSIM_t00150 tRNA-Tyr\tK14236 tRNA-Tyr; tRNA Tyr" }, { "name":"MSIM_t00020 tRNA-Val\tK14237 tRNA-Val; tRNA Val" }, { "name":"MSIM_t00050 tRNA-Val\tK14237 tRNA-Val; tRNA Val" }, { "name":"MSIM_t00500 tRNA-Val\tK14237 tRNA-Val; tRNA Val" }, { "name":"MSIM_t00180 tRNA-Sec\tK14238 tRNA-Sec; tRNA Sec" }, { "name":"MSIM_08220 gltX; glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]" }, { "name":"MSIM_03070 amidase\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_08390 gatA_1; glutamyl-tRNA(Gln) amidotransferase subunit A\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_08360 gatB; aspartyl\/glutamyl-tRNA(Asn\/Gln) amidotransferase subunit B\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_08400 gatC; glutamyl-tRNA(Gln) amidotransferase subunit C\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_03340 alaS; alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]" }, { "name":"MSIM_03470 aspS; aspartate--tRNA(Asp\/Asn) ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]" }, { "name":"MSIM_42880 glyQS; glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]" }, { "name":"MSIM_04190 thrS; threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]" }, { "name":"MSIM_25730 serS; serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]" }, { "name":"MSIM_23310 selA; L-seryl-tRNA(Sec) selenium transferase\tK01042 selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]" }, { "name":"MSIM_28890 cysS; cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]" }, { "name":"MSIM_36400 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]" }, { "name":"MSIM_02640 fmt; methionyl-tRNA formyltransferase\tK00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]" }, { "name":"MSIM_11830 putative formyltransferase\tK00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]" }, { "name":"MSIM_41780 valS; valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]" }, { "name":"MSIM_24480 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]" }, { "name":"MSIM_01490 ileS; isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]" }, { "name":"MSIM_00380 lysX; lysylphosphatidylglycerol biosynthesis bifunctional protein LysX\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]" }, { "name":"MSIM_28690 lysS1; lysine--tRNA ligase 1\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]" }, { "name":"MSIM_39590 argS; arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]" }, { "name":"MSIM_06380 proS; proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]" }, { "name":"MSIM_03810 hisS; histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]" }, { "name":"MSIM_00300 pheS; phenylalanine--tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]" }, { "name":"MSIM_00290 pheT; phenylalanine--tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]" }, { "name":"MSIM_54140 tyrS; tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]" }, { "name":"MSIM_14150 trpS; tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]" } ] }, { "name":"03013 Nucleocytoplasmic transport" }, { "name":"03015 mRNA surveillance pathway" }, { "name":"03008 Ribosome biogenesis in eukaryotes [PATH:msim03008]", "children":[ { "name":"MSIM_07670 rnc; ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]" }, { "name":"MSIM_41200 orn; oligoribonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]" } ] } ] }, { "name":"09123 Folding, sorting and degradation", "children":[ { "name":"03060 Protein export [PATH:msim03060]", "children":[ { "name":"MSIM_15550 secY; protein translocase subunit SecY\tK03076 secY; preprotein translocase subunit SecY" }, { "name":"MSIM_16520 secE; protein translocase subunit SecE\tK03073 secE; preprotein translocase subunit SecE" }, { "name":"MSIM_02380 secG; putative protein-export membrane protein SecG\tK03075 secG; preprotein translocase subunit SecG" }, { "name":"MSIM_03890 hypothetical protein\tK03072 secD; preprotein translocase subunit SecD" }, { "name":"MSIM_03880 secF; protein translocase subunit SecF\tK03074 secF; preprotein translocase subunit SecF" }, { "name":"MSIM_03900 hypothetical protein\tK03210 yajC; preprotein translocase subunit YajC" }, { "name":"MSIM_25140 yidC; membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase" }, { "name":"MSIM_12820 secA1; protein translocase subunit SecA 1\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_51860 secA2; protein translocase subunit SecA 2\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_07530 ffh; signal recognition particle protein\tK03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]" }, { "name":"MSIM_07590 ftsY; signal recognition particle receptor FtsY\tK03110 ftsY; fused signal recognition particle receptor" }, { "name":"MSIM_46020 hypothetical protein\tK01551 arsA; arsenite\/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]" }, { "name":"MSIM_47250 tatA; Sec-independent protein translocase protein TatA\tK03116 tatA; sec-independent protein translocase protein TatA" }, { "name":"MSIM_38720 tatB; sec-independent protein translocase protein TatB\tK03117 tatB; sec-independent protein translocase protein TatB" }, { "name":"MSIM_47260 tatC; Sec-independent protein translocase protein TatC\tK03118 tatC; sec-independent protein translocase protein TatC" }, { "name":"MSIM_07340 lepB; signal peptidase I\tK03100 lepB; signal peptidase I [EC:3.4.21.89]" }, { "name":"MSIM_01430 lspA; lipoprotein signal peptidase\tK03101 lspA; signal peptidase II [EC:3.4.23.36]" } ] }, { "name":"04141 Protein processing in endoplasmic reticulum [PATH:msim04141]", "children":[ { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" }, { "name":"MSIM_11740 hsp18; 18 kDa antigen\tK13993 HSP20; HSP20 family protein" }, { "name":"MSIM_20130 hsp; heat-shock protein Hsp20\tK13993 HSP20; HSP20 family protein" }, { "name":"MSIM_23940 18 kDa antigen (HSP 16.7)\tK13993 HSP20; HSP20 family protein" } ] }, { "name":"04130 SNARE interactions in vesicular transport" }, { "name":"04120 Ubiquitin mediated proteolysis" }, { "name":"04122 Sulfur relay system [PATH:msim04122]", "children":[ { "name":"MSIM_08500 iscS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]" }, { "name":"MSIM_13620 sseA; putative thiosulfate sulfurtransferase SseA\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_30960 cysA2; thiosulfate sulfurtransferase CysA\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_44610 sseB; putative thiosulfate sulfurtransferase SseB\tK01011 TST; thiosulfate\/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]" }, { "name":"MSIM_08490 mnmA; tRNA-specific 2-thiouridylase MnmA\tK00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]" }, { "name":"MSIM_32840 moaE2; molybdopterin synthase catalytic subunit 2\tK03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12]" }, { "name":"MSIM_32880 moaA2; GTP 3',8-cyclase 2\tK03639 moaA; GTP 3',8-cyclase [EC:4.1.99.22]" }, { "name":"MSIM_32870 moaD2; molybdopterin synthase sulfur carrier subunit\tK03636 moaD; sulfur-carrier protein" }, { "name":"MSIM_12170 moeZ; putative adenylyltransferase\/sulfurtransferase MoeZ\tK21147 moeZR; sulfur-carrier protein adenylyltransferase\/sulfurtransferase [EC:2.7.7.80 2.7.7.- 2.8.1.11 2.8.1.-]" }, { "name":"MSIM_32820 moaC2; cyclic pyranopterin monophosphate synthase accessory protein 2\tK03637 moaC; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]" }, { "name":"MSIM_18530 thiamine biosynthesis protein ThiS\tK03154 thiS; sulfur carrier protein" }, { "name":"MSIM_39990 mec; CysO-cysteine peptidase\tK21140 mec; [CysO sulfur-carrier protein]-S-L-cysteine hydrolase [EC:3.13.1.6]" } ] }, { "name":"03050 Proteasome [PATH:msim03050]", "children":[ { "name":"MSIM_47150 mpa; proteasome-associated ATPase\tK13527 mpa; proteasome-associated ATPase" }, { "name":"MSIM_47210 prcA; proteasome subunit alpha\tK03432 psmA; proteasome alpha subunit [EC:3.4.25.1]" }, { "name":"MSIM_47200 prcB; proteasome subunit beta\tK03433 psmB; proteasome beta subunit [EC:3.4.25.1]" } ] }, { "name":"03018 RNA degradation [PATH:msim03018]", "children":[ { "name":"MSIM_41820 ribonuclease\tK08300 rne; ribonuclease E [EC:3.1.26.12]" }, { "name":"MSIM_36760 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"MSIM_05890 pnp; polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]" }, { "name":"MSIM_38950 deaD; ATP-dependent RNA helicase DeaD\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]" }, { "name":"MSIM_43790 recQ; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]" }, { "name":"MSIM_39640 rho; transcription termination factor Rho\tK03628 rho; transcription termination factor Rho" }, { "name":"MSIM_05440 rnj; ribonuclease J\tK12574 rnj; ribonuclease J [EC:3.1.-.-]" }, { "name":"MSIM_19180 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"MSIM_14830 groL1; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_18110 groL_1; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_49500 groL_2; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_08150 ppk; polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]" }, { "name":"MSIM_12750 ppk2; polyphosphate kinase\tK22468 ppk2; polyphosphate kinase [EC:2.7.4.34]" }, { "name":"MSIM_25300 pcnA; CCA tRNA nucleotidyltransferase\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]" } ] } ] }, { "name":"09124 Replication and repair", "children":[ { "name":"03030 DNA replication [PATH:msim03030]", "children":[ { "name":"MSIM_27330 dnaQ; DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_45940 hypothetical protein\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_01360 dnaE1; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]" }, { "name":"MSIM_27190 DNA polymerase III, subunit gamma\/tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]" }, { "name":"MSIM_28280 DNA polymerase\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]" }, { "name":"MSIM_42220 hypothetical protein\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]" }, { "name":"MSIM_25090 dnaN; DNA polymerase III subunit beta\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]" }, { "name":"MSIM_24130 replicative DNA helicase\tK02314 dnaB; replicative DNA helicase [EC:5.6.2.3]" }, { "name":"MSIM_42960 dnaG; DNA primase\tK02316 dnaG; DNA primase [EC:2.7.7.101]" }, { "name":"MSIM_24160 ssb; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_41500 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_45420 hypothetical protein\tK22316 rhnA-cobC; ribonuclease H \/ adenosylcobalamin\/alpha-ribazole phosphatase [EC:3.1.26.4 3.1.3.73]" }, { "name":"MSIM_07330 rnhB; ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]" }, { "name":"MSIM_00680 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]" }, { "name":"MSIM_08450 ligA; DNA ligase A\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]" } ] }, { "name":"03410 Base excision repair [PATH:msim03410]", "children":[ { "name":"MSIM_27990 nth; endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]" }, { "name":"MSIM_08090 ung; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]" }, { "name":"MSIM_28790 mutY; A\/G-specific adenine glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]" }, { "name":"MSIM_54150 putative 3-methyladenine DNA glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]" }, { "name":"MSIM_00640 mutM_1; formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]" }, { "name":"MSIM_07660 mutM_2; formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]" }, { "name":"MSIM_34640 putative formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]" }, { "name":"MSIM_13720 nei2; endonuclease 8 2\tK05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]" }, { "name":"MSIM_41640 nei1; endonuclease 8 1\tK05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]" }, { "name":"MSIM_39830 alkA; putative bifunctional transcriptional activator\/DNA repair enzyme AlkA\tK13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response \/ DNA-3-methyladenine glycosylase II [EC:3.2.2.21]" }, { "name":"MSIM_38600 tagA; DNA-3-methyladenine glycosylase I\tK01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]" }, { "name":"MSIM_33180 mug; G\/U mismatch-specific DNA glycosylase\tK03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]" }, { "name":"MSIM_11580 uracil-DNA glycosylase\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]" }, { "name":"MSIM_39020 hypothetical protein\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]" }, { "name":"MSIM_18340 xthA; exodeoxyribonuclease III\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]" }, { "name":"MSIM_16280 deoxyribonuclease IV\tK01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]" }, { "name":"MSIM_00680 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]" }, { "name":"MSIM_08450 ligA; DNA ligase A\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]" } ] }, { "name":"03420 Nucleotide excision repair [PATH:msim03420]", "children":[ { "name":"MSIM_36720 mfd; transcription-repair-coupling factor\tK03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]" }, { "name":"MSIM_00490 uvrA; UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A" }, { "name":"MSIM_00560 uvrB; UvrABC system protein B\tK03702 uvrB; excinuclease ABC subunit B" }, { "name":"MSIM_02500 uvrC; UvrABC system protein C\tK03703 uvrC; excinuclease ABC subunit C" }, { "name":"MSIM_12070 uvrD2; ATP-dependent DNA helicase UvrD2\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_12110 ATP-dependent DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_34690 uvrD1; ATP-dependent DNA helicase UvrD1\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_00680 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]" }, { "name":"MSIM_08450 ligA; DNA ligase A\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]" }, { "name":"MSIM_32790 helicase\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]" } ] }, { "name":"03430 Mismatch repair [PATH:msim03430]", "children":[ { "name":"MSIM_12070 uvrD2; ATP-dependent DNA helicase UvrD2\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_12110 ATP-dependent DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_34690 uvrD1; ATP-dependent DNA helicase UvrD1\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_37410 xseA; exodeoxyribonuclease 7 large subunit\tK03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]" }, { "name":"MSIM_37400 xseB; exodeoxyribonuclease 7 small subunit\tK03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]" }, { "name":"MSIM_24160 ssb; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_41500 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_01360 dnaE1; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]" }, { "name":"MSIM_25090 dnaN; DNA polymerase III subunit beta\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]" }, { "name":"MSIM_27190 DNA polymerase III, subunit gamma\/tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]" }, { "name":"MSIM_42220 hypothetical protein\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]" }, { "name":"MSIM_28280 DNA polymerase\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]" }, { "name":"MSIM_27330 dnaQ; DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_45940 hypothetical protein\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_08450 ligA; DNA ligase A\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]" } ] }, { "name":"03440 Homologous recombination [PATH:msim03440]", "children":[ { "name":"MSIM_24160 ssb; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_41500 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_25080 recF; DNA replication and repair protein RecF\tK03629 recF; DNA replication and repair protein RecF" }, { "name":"MSIM_42830 recO; DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)" }, { "name":"MSIM_27290 recR; recombination protein RecR\tK06187 recR; recombination protein RecR" }, { "name":"MSIM_05300 recA; protein RecA\tK03553 recA; recombination protein RecA" }, { "name":"MSIM_00680 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]" }, { "name":"MSIM_03960 ruvA; Holliday junction ATP-dependent DNA helicase RuvA\tK03550 ruvA; holliday junction DNA helicase RuvA" }, { "name":"MSIM_03950 ruvB; Holliday junction ATP-dependent DNA helicase RuvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]" }, { "name":"MSIM_03970 ruvC; crossover junction endodeoxyribonuclease RuvC\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]" }, { "name":"MSIM_08030 recG; ATP-dependent DNA helicase RecG\tK03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]" }, { "name":"MSIM_01360 dnaE1; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]" }, { "name":"MSIM_25090 dnaN; DNA polymerase III subunit beta\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]" }, { "name":"MSIM_27190 DNA polymerase III, subunit gamma\/tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]" }, { "name":"MSIM_42220 hypothetical protein\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]" }, { "name":"MSIM_28280 DNA polymerase\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]" }, { "name":"MSIM_27330 dnaQ; DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_45940 hypothetical protein\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_02780 priA_2; putative primosomal protein N'\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]" } ] }, { "name":"03450 Non-homologous end-joining [PATH:msim03450]", "children":[ { "name":"MSIM_34490 mku; non-homologous end joining protein Ku\tK10979 ku; DNA end-binding protein Ku" }, { "name":"MSIM_00630 ATP-dependent DNA ligase\tK01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]" }, { "name":"MSIM_34550 ligD; multifunctional non-homologous end joining protein LigD\tK01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]" } ] }, { "name":"03460 Fanconi anemia pathway" } ] }, { "name":"09126 Chromosome", "children":[ { "name":"03082 ATP-dependent chromatin remodeling" }, { "name":"03083 Polycomb repressive complex" } ] }, { "name":"09125 Information processing in viruses", "children":[ { "name":"03230 Viral genome structure" }, { "name":"03240 Viral replication" }, { "name":"03250 Viral life cycle - HIV-1 [PATH:msim03250]", "children":[ { "name":"MSIM_25000 ppiA; peptidyl-prolyl cis-trans isomerase A\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]" } ] }, { "name":"03260 Virion - Human immunodeficiency virus" }, { "name":"03271 Virion - Rotavirus" }, { "name":"03262 Virion - Coronavirus" }, { "name":"03261 Virion - Influenza virus" }, { "name":"03263 Virion - Enterovirus" }, { "name":"03264 Virion - Flavivirus and Alphavirus" }, { "name":"03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus" }, { "name":"03273 Virion - Lassa virus and SFTS virus" }, { "name":"03272 Virion - Hepatitis viruses" }, { "name":"03266 Virion - Herpesvirus" }, { "name":"03268 Virion - Orthopoxvirus" }, { "name":"03267 Virion - Adenovirus" }, { "name":"03259 Virion - Bacteriophages T4 and T7" }, { "name":"03258 Virion - Bacteriophage lambda" } ] } ] }, { "name":"09130 Environmental Information Processing", "children":[ { "name":"09131 Membrane transport", "children":[ { "name":"02010 ABC transporters [PATH:msim02010]", "children":[ { "name":"MSIM_42370 subI; sulfate ABC transporter substrate-binding protein\tK23163 sbp; sulfate\/thiosulfate transport system substrate-binding protein" }, { "name":"MSIM_42380 cysT; sulfate ABC transporter permease subunit CysT\tK02046 cysU; sulfate\/thiosulfate transport system permease protein" }, { "name":"MSIM_42390 cysW; sulfate ABC transporter permease CysW\tK02047 cysW; sulfate\/thiosulfate transport system permease protein" }, { "name":"MSIM_42400 cysA; sulfate\/thiosulfate import ATP-binding protein CysA\tK02045 cysA; sulfate\/thiosulfate transport system ATP-binding protein [EC:7.3.2.3]" }, { "name":"MSIM_03170 putative nitrate ABC transporter, periplasmic protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_23240 aliphatic sulfonate ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_23730 ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_32730 ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_03160 putative nitrate ABC transporter, permease protein\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_23220 sulfate ABC transporter permease\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_23720 putative nitrate ABC transporter, permease protein\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_32750 ABC transporter permease\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_03150 putative nitrate ABC transporter, ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_23230 ABC transporter ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_23710 ABC transporter ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_32740 ssuB; aliphatic sulfonates import ATP-binding protein SsuB\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_51430 modA; molybdate-binding protein\tK02020 modA; molybdate transport system substrate-binding protein" }, { "name":"MSIM_51420 modB; molybdenum transport system permease protein ModB\tK02018 modB; molybdate transport system permease protein" }, { "name":"MSIM_51410 modC; molybdenum import ATP-binding protein ModC\tK02017 modC; molybdate transport system ATP-binding protein [EC:7.3.2.5]" }, { "name":"MSIM_26500 proX; glycine\/betaine ABC transporter substrate-binding protein\tK05845 opuC; osmoprotectant transport system substrate-binding protein" }, { "name":"MSIM_26520 proW; ABC transporter permease\tK05846 opuBD; osmoprotectant transport system permease protein" }, { "name":"MSIM_26530 proZ; ABC transporter permease\tK05846 opuBD; osmoprotectant transport system permease protein" }, { "name":"MSIM_26510 proV; proline\/glycine betaine ABC transporter ATP-binding protein\tK05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9]" }, { "name":"MSIM_38820 sugC; trehalose import ATP-binding protein SugC\tK10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]" }, { "name":"MSIM_47980 sugar ABC transporter ATP-binding protein\tK10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]" }, { "name":"MSIM_38790 lpqY; hypothetical protein\tK10236 thuE; trehalose\/maltose transport system substrate-binding protein" }, { "name":"MSIM_38800 sugA; trehalose transport system permease protein SugA\tK10237 thuF; trehalose\/maltose transport system permease protein" }, { "name":"MSIM_38810 sugB; trehalose transport system permease protein SugB\tK10238 thuG; trehalose\/maltose transport system permease protein" }, { "name":"MSIM_21230 mce1F; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21240 lprK; lipoprotein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21250 mce1D; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21260 mce1C; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21270 mce1B; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21280 mce1A; cell invasion protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29740 mce4A; Mce family protein Mce4A\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29750 mce4B; Mce family protein Mce4B\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29760 mce4C; Mce family protein Mce4C\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29770 mce4D; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29780 lprN; hypothetical protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29790 mce4F; Mce family protein Mce4\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_30850 mce2A; Mce family protein Mce2A\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32330 virulence factor\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32340 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32350 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32360 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32370 virulence factor Mce\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32380 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43050 mce3A; MCE-family protein MCE3A\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43060 mce3B; Mce family protein Mce3B\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43070 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43080 mce3D; Mce family protein Mce3D\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43090 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43100 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_46970 putative Mce family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_46980 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_46990 putative MCE family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_47000 putative MCE family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_47010 putative MCE family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_47020 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21290 yrbE1B; ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_21300 yrbE1A; membrane protein\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_29720 yrbE4A; ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_29730 yrbE4B; ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_32310 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_32320 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_43030 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_43040 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_47030 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_47040 ABC transporter\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_16310 mkl; putative ribonucleotide transport ATP-binding protein mkl\tK02065 mlaF; phospholipid\/cholesterol\/gamma-HCH transport system ATP-binding protein" }, { "name":"MSIM_15850 pstS3_1; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_31020 phoS3; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_34460 pstS3_2; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_49030 pstS2; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_31030 pstC; phosphate transport system permease protein\tK02037 pstC; phosphate transport system permease protein" }, { "name":"MSIM_34470 pstC2; phosphate transport system permease protein PstC 2\tK02037 pstC; phosphate transport system permease protein" }, { "name":"MSIM_31040 pstA; phosphate transport system permease protein PstA\tK02038 pstA; phosphate transport system permease protein" }, { "name":"MSIM_34480 pstA1; phosphate transport system permease protein PstA 1\tK02038 pstA; phosphate transport system permease protein" }, { "name":"MSIM_31050 pstB; phosphate import ATP-binding protein PstB\tK02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]" }, { "name":"MSIM_24290 phnD; phosphate-import protein PhnD\tK02044 phnD; phosphonate transport system substrate-binding protein" }, { "name":"MSIM_24270 phnE; phosphate-import permease protein PhnE\tK02042 phnE; phosphonate transport system permease protein" }, { "name":"MSIM_24280 phnC; phosphate-import ATP-binding protein PhnC\tK02041 phnC; phosphonate transport system ATP-binding protein [EC:7.3.2.2]" }, { "name":"MSIM_37880 hypothetical protein\tK01999 livK; branched-chain amino acid transport system substrate-binding protein" }, { "name":"MSIM_28090 dppA; peptide ABC transporter substrate-binding protein\tK15580 oppA; oligopeptide transport system substrate-binding protein" }, { "name":"MSIM_28100 dppB; peptide ABC transporter\tK15581 oppB; oligopeptide transport system permease protein" }, { "name":"MSIM_28110 dppC; peptide ABC transporter permease\tK15582 oppC; oligopeptide transport system permease protein" }, { "name":"MSIM_28120 dppD; peptide ABC transporter ATP-binding protein\tK10823 oppF; oligopeptide transport system ATP-binding protein" }, { "name":"MSIM_39300 hypothetical protein\tK13889 gsiB; glutathione transport system substrate-binding protein" }, { "name":"MSIM_39330 peptide ABC transporter permease\tK13890 gsiC; glutathione transport system permease protein" }, { "name":"MSIM_39320 putative peptide transport permease protein\tK13891 gsiD; glutathione transport system permease protein" }, { "name":"MSIM_39310 putative ABC transporter ATP-binding protein\tK13892 gsiA; glutathione transport system ATP-binding protein" }, { "name":"MSIM_43260 hypothetical protein\tK16785 ecfT; energy-coupling factor transport system permease protein" }, { "name":"MSIM_26180 sugar ABC transporter permease\tK09690 wzm; homopolymeric O-antigen transport system permease protein" }, { "name":"MSIM_26200 ABC transporter ATP-binding protein\tK09691 wzt; homopolymeric O-antigen transport system ATP-binding protein [EC:7.5.2.14]" }, { "name":"MSIM_10710 ftsX; cell division protein FtsX\tK09811 ftsX; cell division transport system permease protein" }, { "name":"MSIM_10720 ftsE; cell division ATP-binding protein FtsE\tK09812 ftsE; cell division transport system ATP-binding protein" }, { "name":"MSIM_40140 irtA; iron import ATP-binding\/permease protein IrtA\tK14698 irtA; ATP-binding cassette, subfamily B, bacterial IrtA\/YbtP [EC:7.-.-.-]" }, { "name":"MSIM_40150 irtB; iron import ATP-binding\/permease protein IrtB\tK14699 irtB; ATP-binding cassette, subfamily B, bacterial IrtB\/YbtQ [EC:7.-.-.-]" }, { "name":"MSIM_39220 putative ABC transporter ATP-binding protein\tK18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump" }, { "name":"MSIM_00780 cydC; thiol reductant ABC exporter subunit CydC\tK16012 cydC; ATP-binding cassette, subfamily C, bacterial CydC" }, { "name":"MSIM_00770 cydD; thiol reductant ABC exporter subunit CydD\tK16013 cydD; ATP-binding cassette, subfamily C, bacterial CydD" }, { "name":"MSIM_51880 bacA; vitamin B12 transport ATP-binding protein BacA\tK02471 bacA; vitamin B12\/bleomycin\/antimicrobial peptide transport system ATP-binding\/permease protein" } ] }, { "name":"02060 Phosphotransferase system (PTS)" }, { "name":"03070 Bacterial secretion system [PATH:msim03070]", "children":[ { "name":"MSIM_03890 hypothetical protein\tK03072 secD; preprotein translocase subunit SecD" }, { "name":"MSIM_03880 secF; protein translocase subunit SecF\tK03074 secF; preprotein translocase subunit SecF" }, { "name":"MSIM_16520 secE; protein translocase subunit SecE\tK03073 secE; preprotein translocase subunit SecE" }, { "name":"MSIM_02380 secG; putative protein-export membrane protein SecG\tK03075 secG; preprotein translocase subunit SecG" }, { "name":"MSIM_15550 secY; protein translocase subunit SecY\tK03076 secY; preprotein translocase subunit SecY" }, { "name":"MSIM_03900 hypothetical protein\tK03210 yajC; preprotein translocase subunit YajC" }, { "name":"MSIM_25140 yidC; membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase" }, { "name":"MSIM_12820 secA1; protein translocase subunit SecA 1\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_51860 secA2; protein translocase subunit SecA 2\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_07590 ftsY; signal recognition particle receptor FtsY\tK03110 ftsY; fused signal recognition particle receptor" }, { "name":"MSIM_07530 ffh; signal recognition particle protein\tK03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]" }, { "name":"MSIM_47250 tatA; Sec-independent protein translocase protein TatA\tK03116 tatA; sec-independent protein translocase protein TatA" }, { "name":"MSIM_38720 tatB; sec-independent protein translocase protein TatB\tK03117 tatB; sec-independent protein translocase protein TatB" }, { "name":"MSIM_47260 tatC; Sec-independent protein translocase protein TatC\tK03118 tatC; sec-independent protein translocase protein TatC" } ] } ] }, { "name":"09132 Signal transduction", "children":[ { "name":"02020 Two-component system [PATH:msim02020]", "children":[ { "name":"MSIM_17640 senX3; sensor-like histidine kinase senX3\tK07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3]" }, { "name":"MSIM_17630 regX3; sensory transduction protein regX3\tK07776 regX3; two-component system, OmpR family, response regulator RegX3" }, { "name":"MSIM_15850 pstS3_1; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_31020 phoS3; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_34460 pstS3_2; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_49030 pstS2; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_38710 htrA; serine protease HtrA\tK04771 degP; serine protease Do [EC:3.4.21.107]" }, { "name":"MSIM_36810 kdpD; sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]" }, { "name":"MSIM_36800 kdpE; DNA-binding response regulator\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE" }, { "name":"MSIM_36840 kdpA; potassium-transporting ATPase potassium-binding subunit\tK01546 kdpA; potassium-transporting ATPase potassium-binding subunit" }, { "name":"MSIM_36830 kdpB; potassium-transporting ATPase ATP-binding subunit\tK01547 kdpB; potassium-transporting ATPase ATP-binding subunit [EC:7.2.2.6]" }, { "name":"MSIM_36820 kdpC; potassium-transporting ATPase KdpC subunit\tK01548 kdpC; potassium-transporting ATPase KdpC subunit" }, { "name":"MSIM_02250 heme A synthase\tK02259 COX15; heme a synthase [EC:1.17.99.9]" }, { "name":"MSIM_34930 mprB; signal transduction histidine-protein kinase\/phosphatase MprB\tK07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]" }, { "name":"MSIM_34920 mprA; response regulator MprA\tK07669 mprA; two-component system, OmpR family, response regulator MprA" }, { "name":"MSIM_34940 serine protease\tK08372 pepD; putative serine protease PepD [EC:3.4.21.-]" }, { "name":"MSIM_12910 mtrB; sensor histidine kinase MtrB\tK07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]" }, { "name":"MSIM_12920 mtrA; DNA-binding response regulator MtrA\tK07670 mtrA; two-component system, OmpR family, response regulator MtrA" }, { "name":"MSIM_25100 dnaA; chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein" }, { "name":"MSIM_23280 two-component sensor histidine kinase\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]" }, { "name":"MSIM_33110 prrB; sensor-type histidine kinase PrrB\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]" }, { "name":"MSIM_33120 prrA_2; transcriptional regulatory protein PrrA\tK07671 prrA; two-component system, OmpR family, response regulator PrrA" }, { "name":"MSIM_36850 trcS; two-component sensor histidine kinase\tK07656 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3]" }, { "name":"MSIM_36860 trcR; DNA-binding response regulator\tK07672 trcR; two-component system, OmpR family, response regulator TrcR" }, { "name":"MSIM_31300 lpqR; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]" }, { "name":"MSIM_09700 citE_1; citrate lyase subunit beta\tK01644 citE; citrate lyase subunit beta \/ citryl-CoA lyase [EC:4.1.3.34]" }, { "name":"MSIM_26720 malyl-CoA lyase\tK01644 citE; citrate lyase subunit beta \/ citryl-CoA lyase [EC:4.1.3.34]" }, { "name":"MSIM_41320 citE_2; citrate lyase subunit beta-like protein\tK01644 citE; citrate lyase subunit beta \/ citryl-CoA lyase [EC:4.1.3.34]" }, { "name":"MSIM_38860 putative malate dehydrogenase\tK00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]" }, { "name":"MSIM_43140 mez; NAD-dependent malic enzyme\tK00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]" }, { "name":"MSIM_48390 oxalate\/formate MFS antiporter\tK08177 oxlT; MFS transporter, OFA family, oxalate\/formate antiporter" }, { "name":"MSIM_31470 narL; putative transcriptional regulatory protein NarL\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL" }, { "name":"MSIM_48260 diguanylate cyclase\tK07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]" }, { "name":"MSIM_48250 devR; transcriptional regulatory protein DevR (DosR)\tK07695 devR; two-component system, NarL family, response regulator DevR" }, { "name":"MSIM_28160 conjugal transfer protein\tK02283 cpaF; pilus assembly protein CpaF [EC:7.4.2.8]" }, { "name":"MSIM_28170 hypothetical protein\tK12510 tadB; tight adherence protein B" }, { "name":"MSIM_28180 hypothetical protein\tK12511 tadC; tight adherence protein C" }, { "name":"MSIM_07560 glnD; bifunctional uridylyltransferase\/uridylyl-removing enzyme\tK00990 glnD; [protein-PII] uridylyltransferase [EC:2.7.7.59]" }, { "name":"MSIM_07570 glnB; nitrogen regulatory protein P-II\tK04751 glnB; nitrogen regulatory protein P-II 1" }, { "name":"MSIM_28420 glnT; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45490 glnA2; putative glutamine synthetase 2\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45600 glnA1; glutamine synthetase 1\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51050 glnA3; glutamine synthetase GlnA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51550 type III glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_53180 glnN; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_50360 atoE; short-chain fatty acids transporter\tK02106 atoE; short-chain fatty acids transporter" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_06520 hydrogenase expression protein HypE\tK06282 hyaA; hydrogenase small subunit [EC:1.12.99.6]" }, { "name":"MSIM_06530 hydrogenase\tK06281 hyaB; hydrogenase large subunit [EC:1.12.99.6]" }, { "name":"MSIM_11310 cheR; chemotaxis protein CheR\tK00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80]" }, { "name":"MSIM_11300 hypothetical protein\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_11330 cheB; chemotaxis protein CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_12860 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_27970 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_48380 hypothetical protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_00750 cydA; cytochrome ubiquinol oxidase subunit I\tK00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7]" }, { "name":"MSIM_00760 cydB; cytochrome c oxidase assembly protein\tK00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7]" }, { "name":"MSIM_45370 ptpA; putative low molecular weight protein-tyrosine-phosphatase\tK25307 wzb; low molecular weight protein-tyrosine phosphatase [EC:3.1.3.48]" }, { "name":"MSIM_23800 celA1; glucanase\tK01179 E3.2.1.4; endoglucanase [EC:3.2.1.4]" } ] }, { "name":"04010 MAPK signaling pathway" }, { "name":"04013 MAPK signaling pathway - fly" }, { "name":"04016 MAPK signaling pathway - plant" }, { "name":"04011 MAPK signaling pathway - yeast" }, { "name":"04012 ErbB signaling pathway" }, { "name":"04014 Ras signaling pathway" }, { "name":"04015 Rap1 signaling pathway" }, { "name":"04310 Wnt signaling pathway" }, { "name":"04330 Notch signaling pathway" }, { "name":"04340 Hedgehog signaling pathway" }, { "name":"04341 Hedgehog signaling pathway - fly" }, { "name":"04350 TGF-beta signaling pathway" }, { "name":"04390 Hippo signaling pathway" }, { "name":"04391 Hippo signaling pathway - fly" }, { "name":"04392 Hippo signaling pathway - multiple species" }, { "name":"04370 VEGF signaling pathway" }, { "name":"04371 Apelin signaling pathway" }, { "name":"04630 JAK-STAT signaling pathway" }, { "name":"04064 NF-kappa B signaling pathway" }, { "name":"04668 TNF signaling pathway" }, { "name":"04066 HIF-1 signaling pathway" }, { "name":"04068 FoxO signaling pathway" }, { "name":"04020 Calcium signaling pathway" }, { "name":"04070 Phosphatidylinositol signaling system" }, { "name":"04072 Phospholipase D signaling pathway" }, { "name":"04071 Sphingolipid signaling pathway" }, { "name":"04024 cAMP signaling pathway" }, { "name":"04022 cGMP-PKG signaling pathway" }, { "name":"04151 PI3K-Akt signaling pathway" }, { "name":"04152 AMPK signaling pathway" }, { "name":"04150 mTOR signaling pathway" }, { "name":"04075 Plant hormone signal transduction" } ] }, { "name":"09133 Signaling molecules and interaction", "children":[ { "name":"04080 Neuroactive ligand-receptor interaction" }, { "name":"04082 Neuroactive ligand signaling" }, { "name":"04081 Hormone signaling" }, { "name":"04060 Cytokine-cytokine receptor interaction" }, { "name":"04061 Viral protein interaction with cytokine and cytokine receptor" }, { "name":"04512 ECM-receptor interaction" }, { "name":"04514 Cell adhesion molecule (CAM) interaction" }, { "name":"04517 IgSF CAM signaling" }, { "name":"04518 Integrin signaling" }, { "name":"04519 Cadherin signaling" } ] } ] }, { "name":"09140 Cellular Processes", "children":[ { "name":"09141 Transport and catabolism", "children":[ { "name":"04144 Endocytosis" }, { "name":"04145 Phagocytosis" }, { "name":"04142 Lysosome biogenesis [PATH:msim04142]", "children":[ { "name":"MSIM_23790 sulfatase-modifying factor 1\tK13444 SUMF1; formylglycine-generating enzyme [EC:1.8.3.7]" }, { "name":"MSIM_30680 DUF1211 domain-containing membrane protein\tK24915 TMEM175; TMEM175 potassium channel family protein" } ] }, { "name":"04146 Peroxisome [PATH:msim04146]", "children":[ { "name":"MSIM_32600 far; fatty-acid-CoA racemase\tK01796 AMACR; alpha-methylacyl-CoA racemase [EC:5.1.99.4]" }, { "name":"MSIM_38010 mcr; alpha-methylacyl-CoA racemase\tK01796 AMACR; alpha-methylacyl-CoA racemase [EC:5.1.99.4]" }, { "name":"MSIM_43200 acyl-CoA oxidase\tK00232 ACOX1_3; acyl-CoA oxidase [EC:1.3.3.6]" }, { "name":"MSIM_35640 hypothetical protein\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_43580 AMP-dependent ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_45990 long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_12090 nudC; NADH pyrophosphatase\tK03426 NUDT12_13; NAD+ diphosphatase [EC:3.6.1.22]" }, { "name":"MSIM_45100 flavoprotein\tK00803 AGPS; alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]" }, { "name":"MSIM_40750 aao_1; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_50640 aao_2; amino acid oxidase\tK00273 DAO; D-amino-acid oxidase [EC:1.4.3.3]" }, { "name":"MSIM_14170 icd2; isocitrate dehydrogenase, NADP-dependent\tK00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]" }, { "name":"MSIM_07070 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_10890 hydroxymethylglutaryl-CoA lyase\tK01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]" }, { "name":"MSIM_04380 srpA; catalase-related peroxidase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_23170 catalase-related peroxidase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_27440 katA; catalase\tK03781 katE; catalase [EC:1.11.1.6]" }, { "name":"MSIM_18290 sodC; superoxide dismutase [Cu-Zn]\tK04565 SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]" }, { "name":"MSIM_42950 hypothetical protein\tK04565 SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]" }, { "name":"MSIM_25620 sodA; superoxide dismutase [Mn]\tK04564 SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]" } ] }, { "name":"04149 Peroxisome - yeast" }, { "name":"04140 Autophagy - animal" }, { "name":"04138 Autophagy - yeast" }, { "name":"04136 Autophagy - other" }, { "name":"04137 Mitophagy - animal" }, { "name":"04139 Mitophagy - yeast" }, { "name":"04148 Efferocytosis", "children":[ { "name":"MSIM_25870 hypothetical protein\tK01581 E4.1.1.17; ornithine decarboxylase [EC:4.1.1.17]" } ] } ] }, { "name":"09143 Cell growth and death", "children":[ { "name":"04110 Cell cycle" }, { "name":"04111 Cell cycle - yeast" }, { "name":"04112 Cell cycle - Caulobacter" }, { "name":"04113 Meiosis - yeast" }, { "name":"04114 Oocyte meiosis" }, { "name":"04210 Apoptosis" }, { "name":"04214 Apoptosis - fly" }, { "name":"04215 Apoptosis - multiple species" }, { "name":"04216 Ferroptosis" }, { "name":"04217 Necroptosis" }, { "name":"04115 p53 signaling pathway" }, { "name":"04218 Cellular senescence" }, { "name":"04156 Integrated stress response (ISR) signaling pathway [PATH:msim04156]", "children":[ { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" }, { "name":"MSIM_t00100 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00130 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00480 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_19180 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"MSIM_14830 groL1; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_18110 groL_1; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_49500 groL_2; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" } ] } ] }, { "name":"09144 Cellular community - eukaryotes", "children":[ { "name":"04510 Focal adhesion" }, { "name":"04520 Adherens junction" }, { "name":"04530 Tight junction" }, { "name":"04540 Gap junction" }, { "name":"04550 Signaling pathways regulating pluripotency of stem cells" } ] }, { "name":"09145 Cellular community - prokaryotes", "children":[ { "name":"02024 Quorum sensing [PATH:msim02024]", "children":[ { "name":"MSIM_00890 trpE; anthranilate synthase component 1\tK01657 trpE; anthranilate synthase component I [EC:4.1.3.27]" }, { "name":"MSIM_46080 aroG; phospho-2-dehydro-3-deoxyheptonate aldolase\tK01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]" }, { "name":"MSIM_48710 aroF; phospho-2-dehydro-3-deoxyheptonate aldolase\tK01626 E2.5.1.54; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]" }, { "name":"MSIM_36800 kdpE; DNA-binding response regulator\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE" }, { "name":"MSIM_14910 gadB; glutamate decarboxylase\tK01580 E4.1.1.15; glutamate decarboxylase [EC:4.1.1.15]" }, { "name":"MSIM_37880 hypothetical protein\tK01999 livK; branched-chain amino acid transport system substrate-binding protein" }, { "name":"MSIM_35640 hypothetical protein\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_43580 AMP-dependent ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_45990 long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_12860 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_27970 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_48380 hypothetical protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_02610 ribG; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase\/5-amino-6-(5-phosphoribosylamino)uracil reductase\tK11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase \/ 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]" }, { "name":"MSIM_00670 membrane protein\tK09936 TC.BAT2; bacterial\/archaeal transporter family-2 protein" }, { "name":"MSIM_28090 dppA; peptide ABC transporter substrate-binding protein\tK15580 oppA; oligopeptide transport system substrate-binding protein" }, { "name":"MSIM_28100 dppB; peptide ABC transporter\tK15581 oppB; oligopeptide transport system permease protein" }, { "name":"MSIM_28110 dppC; peptide ABC transporter permease\tK15582 oppC; oligopeptide transport system permease protein" }, { "name":"MSIM_28120 dppD; peptide ABC transporter ATP-binding protein\tK10823 oppF; oligopeptide transport system ATP-binding protein" }, { "name":"MSIM_03870 putative lipoprotein\tK02035 ABC.PE.S; peptide\/nickel transport system substrate-binding protein" }, { "name":"MSIM_25140 yidC; membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase" }, { "name":"MSIM_16520 secE; protein translocase subunit SecE\tK03073 secE; preprotein translocase subunit SecE" }, { "name":"MSIM_02380 secG; putative protein-export membrane protein SecG\tK03075 secG; preprotein translocase subunit SecG" }, { "name":"MSIM_15550 secY; protein translocase subunit SecY\tK03076 secY; preprotein translocase subunit SecY" }, { "name":"MSIM_03900 hypothetical protein\tK03210 yajC; preprotein translocase subunit YajC" }, { "name":"MSIM_12820 secA1; protein translocase subunit SecA 1\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_51860 secA2; protein translocase subunit SecA 2\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_07590 ftsY; signal recognition particle receptor FtsY\tK03110 ftsY; fused signal recognition particle receptor" }, { "name":"MSIM_07530 ffh; signal recognition particle protein\tK03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]" } ] }, { "name":"05111 Biofilm formation - Vibrio cholerae" }, { "name":"02025 Biofilm formation - Pseudomonas aeruginosa" }, { "name":"02026 Biofilm formation - Escherichia coli" } ] }, { "name":"09142 Cell motility", "children":[ { "name":"02030 Bacterial chemotaxis [PATH:msim02030]", "children":[ { "name":"MSIM_11300 hypothetical protein\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_11330 cheB; chemotaxis protein CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_11310 cheR; chemotaxis protein CheR\tK00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80]" } ] }, { "name":"02040 Flagellar assembly", "children":[ { "name":"MSIM_05000 sigA; RNA polymerase sigma factor SigA\tK03086 rpoD; RNA polymerase primary sigma factor" } ] }, { "name":"04814 Motor proteins" }, { "name":"04820 Cytoskeleton in muscle cells", "children":[ { "name":"MSIM_36760 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" } ] }, { "name":"04810 Regulation of actin cytoskeleton" } ] } ] }, { "name":"09150 Organismal Systems", "children":[ { "name":"09151 Immune system", "children":[ { "name":"04640 Hematopoietic cell lineage" }, { "name":"04610 Complement and coagulation cascades" }, { "name":"04611 Platelet activation" }, { "name":"04613 Neutrophil extracellular trap formation" }, { "name":"04620 Toll-like receptor signaling pathway" }, { "name":"04624 Toll and Imd signaling pathway" }, { "name":"04621 NOD-like receptor signaling pathway" }, { "name":"04622 RIG-I-like receptor signaling pathway" }, { "name":"04623 Cytosolic DNA-sensing pathway" }, { "name":"04625 C-type lectin receptor signaling pathway" }, { "name":"04650 Natural killer cell mediated cytotoxicity" }, { "name":"04612 Antigen processing and presentation" }, { "name":"04660 T cell receptor signaling pathway" }, { "name":"04658 Th1 and Th2 cell differentiation" }, { "name":"04659 Th17 cell differentiation" }, { "name":"04657 IL-17 signaling pathway" }, { "name":"04662 B cell receptor signaling pathway" }, { "name":"04664 Fc epsilon RI signaling pathway" }, { "name":"04666 Fc gamma R-mediated phagosome formation" }, { "name":"04670 Leukocyte transendothelial migration" }, { "name":"04672 Intestinal immune network for IgA production" }, { "name":"04062 Chemokine signaling pathway" } ] }, { "name":"09152 Endocrine system", "children":[ { "name":"04911 Insulin secretion" }, { "name":"04910 Insulin signaling pathway" }, { "name":"04922 Glucagon signaling pathway" }, { "name":"04923 Regulation of lipolysis in adipocytes" }, { "name":"04920 Adipocytokine signaling pathway" }, { "name":"03320 PPAR signaling pathway" }, { "name":"04929 GnRH secretion" }, { "name":"04912 GnRH signaling pathway" }, { "name":"04913 Ovarian steroidogenesis" }, { "name":"04915 Estrogen signaling pathway" }, { "name":"04914 Progesterone-mediated oocyte maturation" }, { "name":"04917 Prolactin signaling pathway" }, { "name":"04921 Oxytocin signaling pathway" }, { "name":"04926 Relaxin signaling pathway" }, { "name":"04935 Growth hormone synthesis, secretion and action" }, { "name":"04918 Thyroid hormone synthesis" }, { "name":"04919 Thyroid hormone signaling pathway" }, { "name":"04928 Parathyroid hormone synthesis, secretion and action" }, { "name":"04916 Melanogenesis" }, { "name":"04924 Renin secretion" }, { "name":"04614 Renin-angiotensin system" }, { "name":"04925 Aldosterone synthesis and secretion" }, { "name":"04927 Cortisol synthesis and secretion" } ] }, { "name":"09153 Circulatory system", "children":[ { "name":"04260 Cardiac muscle contraction" }, { "name":"04261 Adrenergic signaling in cardiomyocytes" }, { "name":"04270 Vascular smooth muscle contraction" } ] }, { "name":"09154 Digestive system", "children":[ { "name":"04970 Salivary secretion" }, { "name":"04971 Gastric acid secretion" }, { "name":"04972 Pancreatic secretion" }, { "name":"04976 Bile secretion" }, { "name":"04973 Carbohydrate digestion and absorption" }, { "name":"04974 Protein digestion and absorption" }, { "name":"04975 Fat digestion and absorption" }, { "name":"04979 Cholesterol metabolism" }, { "name":"04977 Vitamin digestion and absorption" }, { "name":"04981 Folate transport and metabolism [PATH:msim04981]", "children":[ { "name":"MSIM_34990 5-formyltetrahydrofolate cyclo-ligase\tK01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]" }, { "name":"MSIM_05510 folA; dihydrofolate reductase\tK00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]" }, { "name":"MSIM_37280 glyA1; serine hydroxymethyltransferase 1\tK00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]" }, { "name":"MSIM_05520 thyA; thymidylate synthase\tK00560 thyA; thymidylate synthase [EC:2.1.1.45]" }, { "name":"MSIM_41700 mmuM; homocysteine S-methyltransferase\tK00547 mmuM; homocysteine S-methyltransferase [EC:2.1.1.10]" }, { "name":"MSIM_46910 5-methyltetrahydrofolate--homocysteine methyltransferase MetH\tK00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]" } ] }, { "name":"04980 Cobalamin transport and metabolism [PATH:msim04980]", "children":[ { "name":"MSIM_39800 Cob(I)yrinic acid a,c-diamide adenosyltransferase\tK00798 MMAB; cob(I)alamin adenosyltransferase [EC:2.5.1.17]" }, { "name":"MSIM_01860 putative GTPase\tK07588 MMAA; GTPase [EC:3.6.5.-]" }, { "name":"MSIM_31450 LAO\/AO transport system ATPase\tK07588 MMAA; GTPase [EC:3.6.5.-]" }, { "name":"MSIM_01870 mutB; putative methylmalonyl-CoA mutase large subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_01880 mutA; putative methylmalonyl-CoA mutase small subunit\tK01847 MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]" }, { "name":"MSIM_46910 5-methyltetrahydrofolate--homocysteine methyltransferase MetH\tK00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]" } ] }, { "name":"04978 Mineral absorption" } ] }, { "name":"09155 Excretory system", "children":[ { "name":"04962 Vasopressin-regulated water reabsorption" }, { "name":"04960 Aldosterone-regulated sodium reabsorption" }, { "name":"04961 Endocrine and other factor-regulated calcium reabsorption" }, { "name":"04964 Proximal tubule bicarbonate reclamation" }, { "name":"04966 Collecting duct acid secretion" } ] }, { "name":"09156 Nervous system", "children":[ { "name":"04724 Glutamatergic synapse" }, { "name":"04727 GABAergic synapse" }, { "name":"04725 Cholinergic synapse" }, { "name":"04728 Dopaminergic synapse" }, { "name":"04726 Serotonergic synapse" }, { "name":"04720 Long-term potentiation" }, { "name":"04730 Long-term depression" }, { "name":"04723 Retrograde endocannabinoid signaling" }, { "name":"04721 Synaptic vesicle cycle" }, { "name":"04722 Neurotrophin signaling pathway" } ] }, { "name":"09157 Sensory system", "children":[ { "name":"04744 Phototransduction" }, { "name":"04745 Phototransduction - fly" }, { "name":"04740 Olfactory transduction" }, { "name":"04742 Taste transduction" }, { "name":"04750 Inflammatory mediator regulation of TRP channels" } ] }, { "name":"09158 Development and regeneration", "children":[ { "name":"04320 Dorso-ventral axis formation" }, { "name":"04360 Axon guidance" }, { "name":"04361 Axon regeneration" }, { "name":"04380 Osteoclast differentiation" }, { "name":"04382 Cornified envelope formation" } ] }, { "name":"09149 Aging", "children":[ { "name":"04211 Longevity regulating pathway" }, { "name":"04212 Longevity regulating pathway - worm" }, { "name":"04213 Longevity regulating pathway - multiple species" } ] }, { "name":"09159 Environmental adaptation", "children":[ { "name":"04710 Circadian rhythm" }, { "name":"04713 Circadian entrainment" }, { "name":"04711 Circadian rhythm - fly" }, { "name":"04712 Circadian rhythm - plant" }, { "name":"04714 Thermogenesis" }, { "name":"04626 Plant-pathogen interaction" } ] } ] }, { "name":"09160 Human Diseases", "children":[ { "name":"09161 Cancer: overview", "children":[ { "name":"05200 Pathways in cancer" }, { "name":"05202 Transcriptional misregulation in cancer" }, { "name":"05206 MicroRNAs in cancer" }, { "name":"05205 Proteoglycans in cancer" }, { "name":"05204 Chemical carcinogenesis - DNA adducts" }, { "name":"05207 Chemical carcinogenesis - receptor activation" }, { "name":"05208 Chemical carcinogenesis - reactive oxygen species" }, { "name":"05203 Viral carcinogenesis" }, { "name":"05230 Central carbon metabolism in cancer" }, { "name":"05231 Choline metabolism in cancer" }, { "name":"05235 PD-L1 expression and PD-1 checkpoint pathway in cancer" } ] }, { "name":"09162 Cancer: specific types", "children":[ { "name":"05210 Colorectal cancer" }, { "name":"05212 Pancreatic cancer" }, { "name":"05225 Hepatocellular carcinoma" }, { "name":"05226 Gastric cancer" }, { "name":"05214 Glioma" }, { "name":"05216 Thyroid cancer" }, { "name":"05221 Acute myeloid leukemia" }, { "name":"05220 Chronic myeloid leukemia" }, { "name":"05217 Basal cell carcinoma" }, { "name":"05218 Melanoma" }, { "name":"05211 Renal cell carcinoma" }, { "name":"05219 Bladder cancer" }, { "name":"05215 Prostate cancer" }, { "name":"05213 Endometrial cancer" }, { "name":"05224 Breast cancer" }, { "name":"05222 Small cell lung cancer" }, { "name":"05223 Non-small cell lung cancer" } ] }, { "name":"09172 Infectious disease: viral", "children":[ { "name":"05166 Human T-cell leukemia virus 1 infection" }, { "name":"05170 Human immunodeficiency virus 1 infection" }, { "name":"05161 Hepatitis B" }, { "name":"05160 Hepatitis C" }, { "name":"05171 Coronavirus disease" }, { "name":"05164 Influenza A" }, { "name":"05162 Measles" }, { "name":"05168 Herpes simplex virus 1 infection" }, { "name":"05163 Human cytomegalovirus infection" }, { "name":"05167 Kaposi sarcoma-associated herpesvirus infection" }, { "name":"05169 Epstein-Barr virus infection" }, { "name":"05165 Human papillomavirus infection" } ] }, { "name":"09171 Infectious disease: bacterial", "children":[ { "name":"05110 Vibrio cholerae infection" }, { "name":"05120 Epithelial cell signaling in Helicobacter pylori infection" }, { "name":"05130 Pathogenic Escherichia coli infection" }, { "name":"05132 Salmonella infection" }, { "name":"05131 Shigellosis" }, { "name":"05135 Yersinia infection" }, { "name":"05133 Pertussis" }, { "name":"05134 Legionellosis" }, { "name":"05150 Staphylococcus aureus infection" }, { "name":"05152 Tuberculosis [PATH:msim05152]", "children":[ { "name":"MSIM_25780 putative Rieske 2Fe-2S iron-sulfur protein\tK14952 namH; UDP-MurNAc hydroxylase" }, { "name":"MSIM_26390 lpqH_1; lipoprotein LpqH\tK14953 lpqH; ipoprotein LpqH" }, { "name":"MSIM_27130 putative lipoprotein\tK14953 lpqH; ipoprotein LpqH" }, { "name":"MSIM_29940 lpqH_2; lipoprotein LpqH\tK14953 lpqH; ipoprotein LpqH" }, { "name":"MSIM_02590 lprG; lipoarabinomannan carrier protein LprG\tK14954 lprG; lipoprotein LprG" }, { "name":"MSIM_39190 lprA; lipoprotein LprA\tK14955 lprA; lipoprotein LprA" }, { "name":"MSIM_15850 pstS3_1; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_31020 phoS3; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_34460 pstS3_2; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_49030 pstS2; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_19180 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"MSIM_14830 groL1; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_18110 groL_1; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_49500 groL_2; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_15090 esxT; ESAT-6-like protein EsxT\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_15100 esxU; ESAT-6-like protein EsxU\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_17430 esxF; ESAT-6-like protein EsxF\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_17440 esxE; secretion protein\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_19820 esxH; ESAT-6-like protein EsxH\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_19830 esxG; type VII secretion system protein EsxS\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_25320 hypothetical protein\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_25330 hypothetical protein\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_36870 esxN_1; ESAT-6-like protein EsxN\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_36880 esxP_1; ESAT-6-like protein EsxP\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_49620 esxN_2; ESAT-6-like protein EsxN\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_52100 esxN_3; ESAT-6-like protein EsxN\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_52110 esxP_2; ESAT-6-like protein EsxP\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_13880 acid phosphatase\tK21302 sapM; phosphatidylinositol-3-phosphatase [EC:3.1.3.64]" }, { "name":"MSIM_18590 pknG; serine\/threonine-protein kinase PknG\tK14949 pknG; serine\/threonine-protein kinase PknG [EC:2.7.11.1]" } ] }, { "name":"05100 Bacterial invasion of epithelial cells" } ] }, { "name":"09174 Infectious disease: parasitic", "children":[ { "name":"05146 Amoebiasis" }, { "name":"05144 Malaria" }, { "name":"05145 Toxoplasmosis" }, { "name":"05140 Leishmaniasis" }, { "name":"05142 Chagas disease" }, { "name":"05143 African trypanosomiasis" } ] }, { "name":"09163 Immune disease", "children":[ { "name":"05310 Asthma" }, { "name":"05322 Systemic lupus erythematosus" }, { "name":"05323 Rheumatoid arthritis" }, { "name":"05320 Autoimmune thyroid disease" }, { "name":"05321 Inflammatory bowel disease" }, { "name":"05330 Allograft rejection" }, { "name":"05332 Graft-versus-host disease" }, { "name":"05340 Primary immunodeficiency" } ] }, { "name":"09164 Neurodegenerative disease", "children":[ { "name":"05010 Alzheimer disease" }, { "name":"05012 Parkinson disease" }, { "name":"05014 Amyotrophic lateral sclerosis" }, { "name":"05016 Huntington disease" }, { "name":"05017 Spinocerebellar ataxia" }, { "name":"05020 Prion disease" }, { "name":"05022 Pathways of neurodegeneration - multiple diseases" } ] }, { "name":"09165 Substance dependence", "children":[ { "name":"05030 Cocaine addiction" }, { "name":"05031 Amphetamine addiction" }, { "name":"05032 Morphine addiction" }, { "name":"05033 Nicotine addiction" }, { "name":"05034 Alcoholism" } ] }, { "name":"09166 Cardiovascular disease", "children":[ { "name":"05417 Lipid and atherosclerosis" }, { "name":"05418 Fluid shear stress and atherosclerosis" }, { "name":"05410 Hypertrophic cardiomyopathy" }, { "name":"05412 Arrhythmogenic right ventricular cardiomyopathy" }, { "name":"05414 Dilated cardiomyopathy" }, { "name":"05415 Diabetic cardiomyopathy" }, { "name":"05416 Viral myocarditis" } ] }, { "name":"09167 Endocrine and metabolic disease", "children":[ { "name":"04930 Type II diabetes mellitus" }, { "name":"04940 Type I diabetes mellitus" }, { "name":"04950 Maturity onset diabetes of the young" }, { "name":"04936 Alcoholic liver disease" }, { "name":"04932 Non-alcoholic fatty liver disease" }, { "name":"04931 Insulin resistance" }, { "name":"04933 AGE-RAGE signaling pathway in diabetic complications" }, { "name":"04934 Cushing syndrome" } ] }, { "name":"09175 Drug resistance: antimicrobial", "children":[ { "name":"01501 beta-Lactam resistance [PATH:msim01501]", "children":[ { "name":"MSIM_20290 lpqI; hypothetical protein\tK01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52]" }, { "name":"MSIM_28090 dppA; peptide ABC transporter substrate-binding protein\tK15580 oppA; oligopeptide transport system substrate-binding protein" }, { "name":"MSIM_28100 dppB; peptide ABC transporter\tK15581 oppB; oligopeptide transport system permease protein" }, { "name":"MSIM_28110 dppC; peptide ABC transporter permease\tK15582 oppC; oligopeptide transport system permease protein" }, { "name":"MSIM_28120 dppD; peptide ABC transporter ATP-binding protein\tK10823 oppF; oligopeptide transport system ATP-binding protein" }, { "name":"MSIM_51670 blaR; hypothetical protein\tK02172 blaR1; bla regulator protein blaR1" }, { "name":"MSIM_51660 blaI; transcriptional regulator BlaI\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor" }, { "name":"MSIM_05860 beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]" }, { "name":"MSIM_46230 pbpB; penicillin-binding protein 2\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]" } ] }, { "name":"01502 Vancomycin resistance [PATH:msim01502]", "children":[ { "name":"MSIM_31300 lpqR; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]" }, { "name":"MSIM_08120 ddl; D-alanine--D-alanine ligase\tK01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]" }, { "name":"MSIM_14900 alr; alanine racemase\tK01775 alr; alanine racemase [EC:5.1.1.1]" }, { "name":"MSIM_46280 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase\tK01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]" }, { "name":"MSIM_46290 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase\tK01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]" }, { "name":"MSIM_46320 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase\tK02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]" } ] }, { "name":"01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:msim01503]", "children":[ { "name":"MSIM_25200 cwlM; N-acetylmuramoyl-L-alanine amidase CwlM\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_27270 N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_44940 hypothetical protein\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_38710 htrA; serine protease HtrA\tK04771 degP; serine protease Do [EC:3.4.21.107]" }, { "name":"MSIM_25000 ppiA; peptidyl-prolyl cis-trans isomerase A\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]" } ] } ] }, { "name":"09176 Drug resistance: antineoplastic", "children":[ { "name":"01521 EGFR tyrosine kinase inhibitor resistance" }, { "name":"01524 Platinum drug resistance" }, { "name":"01523 Antifolate resistance" }, { "name":"01522 Endocrine resistance" } ] } ] }, { "name":"09180 Brite Hierarchies", "children":[ { "name":"09181 Protein families: metabolism", "children":[ { "name":"01000 Enzymes [BR:msim01000]" }, { "name":"01001 Protein kinases [BR:msim01001]", "children":[ { "name":"MSIM_18590 pknG; serine\/threonine-protein kinase PknG\tK14949 pknG; serine\/threonine-protein kinase PknG [EC:2.7.11.1]" }, { "name":"MSIM_00420 hypothetical protein\tK22893 pknH; serine\/threonine kinase PknH [EC:2.7.11.1]" }, { "name":"MSIM_30920 hypothetical protein\tK22893 pknH; serine\/threonine kinase PknH [EC:2.7.11.1]" }, { "name":"MSIM_39120 pknH; serine\/threonine-protein kinase PknH\tK22893 pknH; serine\/threonine kinase PknH [EC:2.7.11.1]" }, { "name":"MSIM_39150 hypothetical protein\tK22893 pknH; serine\/threonine kinase PknH [EC:2.7.11.1]" }, { "name":"MSIM_43880 hypothetical protein\tK22893 pknH; serine\/threonine kinase PknH [EC:2.7.11.1]" }, { "name":"MSIM_44740 protein kinase\tK22893 pknH; serine\/threonine kinase PknH [EC:2.7.11.1]" }, { "name":"MSIM_11620 hypothetical protein\tK12132 prkC; eukaryotic-like serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"MSIM_24940 pknA; serine\/threonine-protein kinase PknA\tK12132 prkC; eukaryotic-like serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"MSIM_24950 pknB; serine\/threonine-protein kinase PknB\tK12132 prkC; eukaryotic-like serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"MSIM_27710 serine\/threonine protein kinase\tK17752 rsbT; serine\/threonine-protein kinase RsbT [EC:2.7.11.1]" }, { "name":"MSIM_00580 hypothetical protein\tK08884 K08884; serine\/threonine protein kinase, bacterial [EC:2.7.11.1]" }, { "name":"MSIM_07510 pknI; serine\/threonine-protein kinase PknI\tK08884 K08884; serine\/threonine protein kinase, bacterial [EC:2.7.11.1]" }, { "name":"MSIM_10520 hypothetical protein\tK08884 K08884; serine\/threonine protein kinase, bacterial [EC:2.7.11.1]" }, { "name":"MSIM_46120 pknL; serine\/threonine-protein kinase PknL\tK08884 K08884; serine\/threonine protein kinase, bacterial [EC:2.7.11.1]" }, { "name":"MSIM_49040 pknD; serine\/threonine-protein kinase PknD\tK08884 K08884; serine\/threonine protein kinase, bacterial [EC:2.7.11.1]" }, { "name":"MSIM_53160 pknE; serine\/threonine-protein kinase PknE\tK08884 K08884; serine\/threonine protein kinase, bacterial [EC:2.7.11.1]" }, { "name":"MSIM_36210 hypothetical protein\tK25588 K25588; tyrosine-protein kinase [EC:2.7.10.3]" }, { "name":"MSIM_17640 senX3; sensor-like histidine kinase senX3\tK07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3]" }, { "name":"MSIM_36810 kdpD; sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]" }, { "name":"MSIM_34930 mprB; signal transduction histidine-protein kinase\/phosphatase MprB\tK07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]" }, { "name":"MSIM_12910 mtrB; sensor histidine kinase MtrB\tK07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]" }, { "name":"MSIM_23280 two-component sensor histidine kinase\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]" }, { "name":"MSIM_33110 prrB; sensor-type histidine kinase PrrB\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]" }, { "name":"MSIM_36850 trcS; two-component sensor histidine kinase\tK07656 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3]" }, { "name":"MSIM_26380 two-component sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]" }, { "name":"MSIM_30140 two-component sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]" }, { "name":"MSIM_48260 diguanylate cyclase\tK07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]" }, { "name":"MSIM_31480 histidine kinase\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]" }, { "name":"MSIM_12330 ATPase\tK00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]" } ] }, { "name":"01009 Protein phosphatases and associated proteins [BR:msim01009]", "children":[ { "name":"MSIM_12940 ahcY; adenosylhomocysteinase\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]" }, { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" }, { "name":"MSIM_24910 pstP; PP2C-family Ser\/Thr phosphatase\tK20074 prpC; PPM family protein phosphatase [EC:3.1.3.16]" }, { "name":"MSIM_08850 phosphoserine phosphatase SerB\tK01079 serB; phosphoserine phosphatase [EC:3.1.3.3]" } ] }, { "name":"01002 Peptidases and inhibitors [BR:msim01002]", "children":[ { "name":"MSIM_01430 lspA; lipoprotein signal peptidase\tK03101 lspA; signal peptidase II [EC:3.4.23.36]" }, { "name":"MSIM_06580 peptidase M52\tK03605 hyaD; hydrogenase maturation protease [EC:3.4.23.-]" }, { "name":"MSIM_14540 guaA; GMP synthase [glutamine-hydrolyzing]\tK01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]" }, { "name":"MSIM_06700 putative glutamine amidotransferase\tK07010 K07010; putative glutamine amidotransferase" }, { "name":"MSIM_02050 peptidase M23\tK21473 ripA; peptidoglycan DL-endopeptidase RipA [EC:3.4.-.-]" }, { "name":"MSIM_02040 peptidase C40\tK21474 ripB; peptidoglycan DL-endopeptidase RipB [EC:3.4.-.-]" }, { "name":"MSIM_30870 purF; amidophosphoribosyltransferase\tK00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]" }, { "name":"MSIM_25450 gltB; glutamate synthase\tK00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]" }, { "name":"MSIM_14990 glmS; glutamine--fructose-6-phosphate aminotransferase [isomerizing]\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]" }, { "name":"MSIM_33470 hypothetical protein\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]" }, { "name":"MSIM_44110 asnB_1; asparagine synthetase B\tK01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]" }, { "name":"MSIM_45830 asnB_2; putative asparagine synthetase [glutamine-hydrolyzing]\tK01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]" }, { "name":"MSIM_27650 peptidase C56 PfpI\tK05520 yhbO; deglycase [EC:3.5.1.124]" }, { "name":"MSIM_41130 hypothetical protein\tK05520 yhbO; deglycase [EC:3.5.1.124]" }, { "name":"MSIM_37990 CAAX protease family protein\tK07052 K07052; CAAX protease family protein" }, { "name":"MSIM_51370 abortive infection protein\tK07052 K07052; CAAX protease family protein" }, { "name":"MSIM_41610 pepN; aminopeptidase\tK01256 pepN; aminopeptidase N [EC:3.4.11.2]" }, { "name":"MSIM_20870 zmp1; zinc metalloprotease\tK07386 pepO; putative endopeptidase [EC:3.4.24.-]" }, { "name":"MSIM_31300 lpqR; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]" }, { "name":"MSIM_45710 pepA_2; putative cytosol aminopeptidase\tK01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]" }, { "name":"MSIM_38530 dapE; succinyl-diaminopimelate desuccinylase\tK01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]" }, { "name":"MSIM_06730 mapB; methionine aminopeptidase\tK01265 map; methionyl aminopeptidase [EC:3.4.11.18]" }, { "name":"MSIM_15530 mapA; methionine aminopeptidase\tK01265 map; methionyl aminopeptidase [EC:3.4.11.18]" }, { "name":"MSIM_18450 peptidase M28\tK28939 lap; leucyl aminopeptidase [EC:3.4.11.1]" }, { "name":"MSIM_18460 lpqL; putative lipoprotein aminopeptidase LpqL\tK28939 lap; leucyl aminopeptidase [EC:3.4.11.1]" }, { "name":"MSIM_28580 ftsH; ATP-dependent zinc metalloprotease FtsH\tK03798 ftsH; cell division protease FtsH [EC:3.4.24.-]" }, { "name":"MSIM_16830 htpX; protease HtpX\tK03799 htpX; heat shock protein HtpX [EC:3.4.24.-]" }, { "name":"MSIM_51670 blaR; hypothetical protein\tK02172 blaR1; bla regulator protein blaR1" }, { "name":"MSIM_38710 htrA; serine protease HtrA\tK04771 degP; serine protease Do [EC:3.4.21.107]" }, { "name":"MSIM_34940 serine protease\tK08372 pepD; putative serine protease PepD [EC:3.4.21.-]" }, { "name":"MSIM_13300 putative protease\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_15140 mycP4; mycosin-4\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_19790 type VII secretion-associated serine protease\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_25370 membrane-anchored mycosin\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_52070 hypothetical protein\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_17950 peptidase\tK01322 PREP; prolyl oligopeptidase [EC:3.4.21.26]" }, { "name":"MSIM_30490 ptrB; oligopeptidase B\tK01354 ptrB; oligopeptidase B [EC:3.4.21.83]" }, { "name":"MSIM_07480 dacB2; D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]" }, { "name":"MSIM_14110 D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]" }, { "name":"MSIM_28370 D-alanyl-D-alanine carboxypeptidase\/D-alanyl-D-alanine-endopeptidase\tK07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase\/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]" }, { "name":"MSIM_41680 clpP1; ATP-dependent Clp protease proteolytic subunit 1\tK01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]" }, { "name":"MSIM_41690 clpP2; ATP-dependent Clp protease proteolytic subunit 2\tK01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]" }, { "name":"MSIM_51200 lon; Lon protease\tK01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]" }, { "name":"MSIM_11990 signal protein PDZ\tK07177 K07177; Lon-like protease" }, { "name":"MSIM_05180 lexA; LexA repressor\tK01356 lexA; repressor LexA [EC:3.4.21.88]" }, { "name":"MSIM_07340 lepB; signal peptidase I\tK03100 lepB; signal peptidase I [EC:3.4.21.89]" }, { "name":"MSIM_31440 pip; proline iminopeptidase\tK01259 pip; proline iminopeptidase [EC:3.4.11.5]" }, { "name":"MSIM_28560 ephA; epoxide hydrolase A\tK27108 ephA_B; epoxide hydrolase A\/B [EC:3.3.2.-]" }, { "name":"MSIM_21080 monoacylglycerol lipase\tK01054 MGLL; acylglycerol lipase [EC:3.1.1.23]" }, { "name":"MSIM_15700 sppA; signal peptide peptidase SppA\tK04773 sppA; protease IV [EC:3.4.21.-]" }, { "name":"MSIM_03670 hypothetical protein\tK06904 GP4; Escherichia\/Staphylococcus phage prohead protease" }, { "name":"MSIM_47210 prcA; proteasome subunit alpha\tK03432 psmA; proteasome alpha subunit [EC:3.4.25.1]" }, { "name":"MSIM_47200 prcB; proteasome subunit beta\tK03433 psmB; proteasome beta subunit [EC:3.4.25.1]" }, { "name":"MSIM_30410 ggtA; bifunctional cephalosporin acylase\/gamma-glutamyltranspeptidase\tK00681 ggt; gamma-glutamyltranspeptidase \/ glutathione hydrolase [EC:2.3.2.2 3.4.19.13]" }, { "name":"MSIM_43360 hypothetical protein\tK03568 tldD; TldD protein" } ] }, { "name":"01003 Glycosyltransferases [BR:msim01003]", "children":[ { "name":"MSIM_47670 hypothetical protein\tK00721 DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]" }, { "name":"MSIM_36120 pmt; putative dolichyl-phosphate-mannose--protein mannosyltransferase\tK00728 POMT; dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]" }, { "name":"MSIM_04150 pimA; phosphatidyl-myo-inositol mannosyltransferase\tK08256 pimA; phosphatidyl-myo-inositol alpha-mannosyltransferase [EC:2.4.1.345]" }, { "name":"MSIM_45980 GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase\tK13668 pimB; phosphatidyl-myo-inositol dimannoside synthase [EC:2.4.1.346]" }, { "name":"MSIM_44630 GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol dimannoside mannosyltransferase\tK14335 pimC; alpha-1,6-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_38170 pimE; polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase\tK13669 pimE; alpha-1,2-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_16900 pimB; GDP-mannose-dependent alpha-mannosyltransferase\tK12583 mgtA; phosphatidylinositol alpha 1,6-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_08570 transferase\tK16150 K16150; glycogen synthase [EC:2.4.1.11]" }, { "name":"MSIM_38620 glgA; capsular glucan synthase\tK16148 glgM; alpha-maltose-1-phosphate synthase [EC:2.4.1.342]" }, { "name":"MSIM_24920 rodA; putative FtsW-like protein\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_46310 ftsW; cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_39690 wecA; decaprenyl-phosphate N-acetylglucosaminephosphotransferase\tK02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate\/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]" }, { "name":"MSIM_46050 hypothetical protein\tK13671 K13671; alpha-1,2-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_46140 hypothetical protein\tK14337 mptA; alpha-1,6-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_02220 membrane protein\tK14339 mptB; alpha-1,6-mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_00530 mannosyltransferase\tK14340 K14340; mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_19580 mannosyltransferase\tK14340 K14340; mannosyltransferase [EC:2.4.1.-]" }, { "name":"MSIM_26050 embA; putative arabinosyltransferase A\tK11385 embA; arabinosyltransferase A [EC:2.4.2.-]" }, { "name":"MSIM_26040 embB; putative arabinosyltransferase B\tK11386 embB; arabinosyltransferase B [EC:2.4.2.-]" }, { "name":"MSIM_26100 embC; putative arabinosyltransferase C\tK11387 embC; arabinosyltransferase C [EC:2.4.2.-]" }, { "name":"MSIM_26110 aftA; arabinofuranosyltransferase AftA\tK13686 aftA; galactan 5-O-arabinofuranosyltransferase [EC:2.4.2.46]" }, { "name":"MSIM_25940 membrane protein\tK13687 aftB; arabinofuranosyltransferase [EC:2.4.2.-]" }, { "name":"MSIM_04740 aftC; alpha-(1->3)-arabinofuranosyltransferase\tK16647 aftC; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.47]" }, { "name":"MSIM_20330 membrane protein\tK16648 aftD; arabinofuranan 3-O-arabinosyltransferase [EC:2.4.2.-]" }, { "name":"MSIM_26220 membrane protein\tK22902 K22902; D-galactosaminyltransferase" }, { "name":"MSIM_26190 galactofuranosyl transferase GlfT1\tK16649 glft1; rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3\/1,4-galactofuranosyltransferase [EC:2.4.1.287]" }, { "name":"MSIM_25910 glfT2; galactofuranosyl transferase GlfT2\tK16650 glft2; galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5\/1,6-galactofuranosyltransferase [EC:2.4.1.288]" }, { "name":"MSIM_13130 wbbL; N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase\tK16870 wbbL; N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase [EC:2.4.1.289]" }, { "name":"MSIM_50010 glycosyl transferase family 1\tK26815 manT; MMP alpha-(1->4)-mannosyltransferase [EC:2.4.1.393]" }, { "name":"MSIM_29830 otsA; trehalose-phosphate synthase\tK00697 otsA; trehalose 6-phosphate synthase [EC:2.4.1.15 2.4.1.347]" }, { "name":"MSIM_38580 gpgS; glucosyl-3-phosphoglycerate synthase\tK13693 gpgS; glucosyl-3-phosphoglycerate synthase [EC:2.4.1.266]" } ] }, { "name":"01005 Lipopolysaccharide biosynthesis proteins [BR:msim01005]", "children":[ { "name":"MSIM_06620 gmhA_1; phosphoheptose isomerase\tK03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]" }, { "name":"MSIM_11500 gmhA_2; phosphoheptose isomerase\tK03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]" }, { "name":"MSIM_36040 gmhA_3; phosphoheptose isomerase\tK03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]" }, { "name":"MSIM_36050 gmhB; D,D-heptose 1,7-bisphosphate phosphatase\tK03273 gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]" }, { "name":"MSIM_11510 bifunctional protein HldE\tK03272 gmhC; D-beta-D-heptose 7-phosphate kinase \/ D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70]" }, { "name":"MSIM_39690 wecA; decaprenyl-phosphate N-acetylglucosaminephosphotransferase\tK02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate\/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]" } ] }, { "name":"01011 Peptidoglycan biosynthesis and degradation proteins [BR:msim01011]", "children":[ { "name":"MSIM_39810 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase\tK00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]" }, { "name":"MSIM_17710 murB; UDP-N-acetylenolpyruvoylglucosamine reductase\tK00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]" }, { "name":"MSIM_46330 murC; UDP-N-acetylmuramate--L-alanine ligase\tK01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]" }, { "name":"MSIM_46300 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase\tK01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]" }, { "name":"MSIM_46270 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\tK01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]" }, { "name":"MSIM_08120 ddl; D-alanine--D-alanine ligase\tK01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]" }, { "name":"MSIM_14900 alr; alanine racemase\tK01775 alr; alanine racemase [EC:5.1.1.1]" }, { "name":"MSIM_40010 murI; glutamate racemase\tK01776 murI; glutamate racemase [EC:5.1.1.3]" }, { "name":"MSIM_46290 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase\tK01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]" }, { "name":"MSIM_46320 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase\tK02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]" }, { "name":"MSIM_46820 uppP; undecaprenyl-diphosphatase\tK06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]" }, { "name":"MSIM_25260 mviN; putative peptidoglycan biosynthesis protein MviN\tK03980 murJ; putative peptidoglycan lipid II flippase" }, { "name":"MSIM_46230 pbpB; penicillin-binding protein 2\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]" }, { "name":"MSIM_24930 pbpA; penicillin-binding protein A\tK05364 pbpA; penicillin-binding protein A" }, { "name":"MSIM_07480 dacB2; D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]" }, { "name":"MSIM_14110 D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]" }, { "name":"MSIM_28370 D-alanyl-D-alanine carboxypeptidase\/D-alanyl-D-alanine-endopeptidase\tK07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase\/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]" }, { "name":"MSIM_24920 rodA; putative FtsW-like protein\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_46310 ftsW; cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_31300 lpqR; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]" }, { "name":"MSIM_02050 peptidase M23\tK21473 ripA; peptidoglycan DL-endopeptidase RipA [EC:3.4.-.-]" }, { "name":"MSIM_02040 peptidase C40\tK21474 ripB; peptidoglycan DL-endopeptidase RipB [EC:3.4.-.-]" }, { "name":"MSIM_03320 membrane protein\tK07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29]" }, { "name":"MSIM_25200 cwlM; N-acetylmuramoyl-L-alanine amidase CwlM\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_27270 N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_44940 hypothetical protein\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" } ] }, { "name":"01004 Lipid biosynthesis proteins [BR:msim01004]", "children":[ { "name":"MSIM_40990 fas; type I polyketide synthase\tK11533 fas; fatty acid synthase, bacteria type [EC:2.3.1.-]" }, { "name":"MSIM_16370 fabD2; malonyl CoA-ACP transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_45180 fabD; malonyl CoA-acyl carrier protein transacylase\tK00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]" }, { "name":"MSIM_13360 hypothetical protein\tK00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]" }, { "name":"MSIM_15480 3-oxoacyl-ACP synthase\tK00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]" }, { "name":"MSIM_12430 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_20250 fabG4; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_22950 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_31770 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34040 oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34210 fabG_3; 3-oxoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_34260 3-ketoacyl-ACP reductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35190 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35590 short-chain dehydrogenase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_35600 hypothetical protein\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_40200 fabG2; putative oxidoreductase\tK00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]" }, { "name":"MSIM_50220 putative 2-nitropropane dioxygenase, NPD\tK02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]" }, { "name":"MSIM_00800 tesB1; acyl-CoA thioesterase II\tK10805 tesB; acyl-CoA thioesterase II [EC:3.1.2.20]" }, { "name":"MSIM_04080 tesB2; acyl-CoA thioesterase II\tK10805 tesB; acyl-CoA thioesterase II [EC:3.1.2.20]" }, { "name":"MSIM_17160 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase 3\tK11608 mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier protein] synthase III [EC:2.3.1.301]" }, { "name":"MSIM_45160 kasA; 3-oxoacyl-[acyl-carrier-protein] synthase 1\tK11609 kasA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase I [EC:2.3.1.293]" }, { "name":"MSIM_14500 kasB_1; 3-oxoacyl-[acyl-carrier-protein] synthase 2\tK27070 kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC:2.3.1.294]" }, { "name":"MSIM_45150 kasB_2; 3-oxoacyl-[acyl-carrier-protein] synthase 2\tK27070 kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC:2.3.1.294]" }, { "name":"MSIM_01970 fabG_1; 3-oxoacyl-[acyl-carrier-protein] reductase FabG\tK11610 mabA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]" }, { "name":"MSIM_16550 UPF0336 protein\tK27071 hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]" }, { "name":"MSIM_16540 hadB; (3R)-hydroxyacyl-ACP dehydratase subunit HadB\tK27072 hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]" }, { "name":"MSIM_23930 (R)-hydratase\tK27689 hadAB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-]" }, { "name":"MSIM_16530 UPF0336 protein\tK27073 hadC; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadC [EC:4.2.1.-]" }, { "name":"MSIM_17480 UPF0336 protein\tK27074 hadD; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadD [EC:4.2.1.-]" }, { "name":"MSIM_01960 inhA; enoyl-[acyl-carrier-protein] reductase [NADH]\tK11611 inhA; meromycolic acid enoyl-[acyl-carrier protein] reductase [EC:1.3.1.118]" }, { "name":"MSIM_31090 desA1_1; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_53420 desA1_2; acyl-ACP desaturase\tK03921 FAB2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]" }, { "name":"MSIM_37290 desA2; acyl-ACP desaturase\tK03922 desA2; acyl-[acyl-carrier protein] desaturase [EC:1.14.19.2 1.14.19.-]" }, { "name":"MSIM_00460 stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_12710 stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_12720 stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_22010 fatty acid desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_40130 desA3; NADPH-dependent stearoyl-CoA 9-desaturase\tK22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]" }, { "name":"MSIM_07840 mas; multifunctional mycocerosic acid synthase\tK11628 mas; mycocerosic acid synthase [EC:2.3.1.111]" }, { "name":"MSIM_47700 pks12; polyketide synthase\tK12436 pks12; mycoketide-CoA synthase [EC:2.3.1.295]" }, { "name":"MSIM_25990 pks13; polyketide synthase\tK12437 pks13; polyketide synthase 13" }, { "name":"MSIM_07720 polyketide synthase\tK12440 ppsA; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase A [EC:2.3.1.292]" }, { "name":"MSIM_07730 hypothetical protein\tK12441 ppsB; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase B [EC:2.3.1.292]" }, { "name":"MSIM_07750 ppsC; phthiocerol synthesis polyketide synthase type I PpsC\tK12442 ppsC; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase C [EC:2.3.1.292]" }, { "name":"MSIM_07760 ppsD; phthiocerol\/phenolphthiocerol synthesis polyketide synthase type I PpsD\tK12443 ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]" }, { "name":"MSIM_07770 ppsE; phthiocerol\/phenolphthiocerol synthesis polyketide synthase type I PpsE\tK12444 ppsE; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase E [EC:2.3.1.292]" }, { "name":"MSIM_22780 putative polyketide synthase MbtC\tK04790 mbtC; mycobactin polyketide synthetase MbtC" }, { "name":"MSIM_42580 polyketide synthase\tK04790 mbtC; mycobactin polyketide synthetase MbtC" }, { "name":"MSIM_22790 putative polyketide synthase MbtD\tK04791 mbtD; mycobactin polyketide synthetase MbtD" }, { "name":"MSIM_42590 mbtD; polyketide synthase\tK04791 mbtD; mycobactin polyketide synthetase MbtD" }, { "name":"MSIM_28060 acsA; acetyl-coenzyme A synthetase\tK01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]" }, { "name":"MSIM_52840 entE; 2,3-dihydroxybenzoate-AMP ligase\tK12507 fadK; acyl-CoA synthetase [EC:6.2.1.-]" }, { "name":"MSIM_35640 hypothetical protein\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_43580 AMP-dependent ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_45990 long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_54210 acyl-CoA synthetase\tK03822 K03822; putative long chain acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_38500 fadD36; acyl-CoA synthetase\tK12429 fadD36; fatty acid CoA ligase FadD36" }, { "name":"MSIM_03920 fadD9; acyl-CoA synthetase\tK12421 fadD9; fatty acid CoA ligase FadD9" }, { "name":"MSIM_22240 oxidoreductase\tK12421 fadD9; fatty acid CoA ligase FadD9" }, { "name":"MSIM_53070 oxidoreductase\tK12421 fadD9; fatty acid CoA ligase FadD9" }, { "name":"MSIM_42130 putative fatty-acid--CoA ligase FadD\tK12423 fadD21; fatty acid CoA ligase FadD21" }, { "name":"MSIM_16960 fadD8; acyl-CoA synthetase\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_22400 AMP-dependent synthetase\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_22960 fadD1; acyl-CoA synthetase\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_29670 fadD17; long-chain-fatty-acid--CoA ligase FadD17\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_36450 pks16; putative ligase\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_38560 fadD6; long-chain-acyl-CoA synthetase\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_50250 AMP-binding protein\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_50350 fadD31; nitrate ABC transporter substrate-binding protein\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_53450 putative ligase\tK00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]" }, { "name":"MSIM_07710 fadD26; long-chain-fatty-acid--AMP ligase FadD26\tK12426 fadD26; long-chain fatty acid adenylase\/transferase FadD26 [EC:6.2.1.59]" }, { "name":"MSIM_25980 fadD32; long-chain-fatty-acid--AMP ligase FadD32\tK12428 fadD32; fatty acyl-AMP ligase FadD32 [EC:6.2.1.-]" }, { "name":"MSIM_01320 plsB1; putative acyltransferase plsB1\tK00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]" }, { "name":"MSIM_41450 plsB; glycerol-3-phosphate acyltransferase\tK00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]" }, { "name":"MSIM_10080 hypothetical protein\tK00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]" }, { "name":"MSIM_46040 1-acyl-sn-glycerol-3-phosphate acyltransferase\tK00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]" }, { "name":"MSIM_00190 pks7; polyketide synthase\tK12434 pks7; polyketide synthase 7" }, { "name":"MSIM_00170 pks8; polyketide synthase\tK12435 pks8; polyketide synthase 8" }, { "name":"MSIM_00160 hypothetical protein\tK12439 pks17; polyketide synthase 17" }, { "name":"MSIM_00180 hypothetical protein\tK12439 pks17; polyketide synthase 17" }, { "name":"MSIM_54350 hypothetical protein\tK12439 pks17; polyketide synthase 17" }, { "name":"MSIM_07920 trans-acting enoyl reductase\tK12445 K12445; trans enoyl reductase [EC:1.3.1.-]" } ] }, { "name":"01008 Polyketide biosynthesis proteins [BR:msim01008]", "children":[ { "name":"MSIM_07720 polyketide synthase\tK12440 ppsA; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase A [EC:2.3.1.292]" }, { "name":"MSIM_07730 hypothetical protein\tK12441 ppsB; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase B [EC:2.3.1.292]" }, { "name":"MSIM_07750 ppsC; phthiocerol synthesis polyketide synthase type I PpsC\tK12442 ppsC; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase C [EC:2.3.1.292]" }, { "name":"MSIM_07760 ppsD; phthiocerol\/phenolphthiocerol synthesis polyketide synthase type I PpsD\tK12443 ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]" }, { "name":"MSIM_07770 ppsE; phthiocerol\/phenolphthiocerol synthesis polyketide synthase type I PpsE\tK12444 ppsE; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase E [EC:2.3.1.292]" }, { "name":"MSIM_47700 pks12; polyketide synthase\tK12436 pks12; mycoketide-CoA synthase [EC:2.3.1.295]" }, { "name":"MSIM_00200 pks10_1; polyketide synthase-like Pks10\tK16167 bpsA; alkylresorcinol\/alkylpyrone synthase" }, { "name":"MSIM_37970 pks10_2; polyketide synthase-like Pks10\tK16167 bpsA; alkylresorcinol\/alkylpyrone synthase" }, { "name":"MSIM_54310 pks11; alpha-pyrone synthesis polyketide synthase-like Pks11\tK16167 bpsA; alkylresorcinol\/alkylpyrone synthase" }, { "name":"MSIM_42630 mbtH; protein MbtH\tK05375 mbtH; MbtH protein" }, { "name":"MSIM_05990 4'-phosphopantetheinyl transferase\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]" }, { "name":"MSIM_42550 mbtA; 2,3-dihydroxybenzoate-AMP ligase\tK04787 mbtA; mycobactin salicyl-AMP ligase [EC:6.3.2.-]" }, { "name":"MSIM_42560 mbtB; phenyloxazoline synthase MbtB\tK04788 mbtB; mycobactin phenyloxazoline synthetase" }, { "name":"MSIM_22780 putative polyketide synthase MbtC\tK04790 mbtC; mycobactin polyketide synthetase MbtC" }, { "name":"MSIM_42580 polyketide synthase\tK04790 mbtC; mycobactin polyketide synthetase MbtC" }, { "name":"MSIM_22790 putative polyketide synthase MbtD\tK04791 mbtD; mycobactin polyketide synthetase MbtD" }, { "name":"MSIM_42590 mbtD; polyketide synthase\tK04791 mbtD; mycobactin polyketide synthetase MbtD" }, { "name":"MSIM_22760 putative peptide synthetase MbtE\tK04789 mbtE; mycobactin peptide synthetase MbtE" }, { "name":"MSIM_42600 hypothetical protein\tK04789 mbtE; mycobactin peptide synthetase MbtE" }, { "name":"MSIM_22750 putative peptide synthetase MbtF\tK04792 mbtF; mycobactin peptide synthetase MbtF" }, { "name":"MSIM_42610 non-ribosomal peptide synthetase\tK04792 mbtF; mycobactin peptide synthetase MbtF" }, { "name":"MSIM_45310 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase" }, { "name":"MSIM_37960 hypothetical protein\tK16168 bpsB; methyltransferase" }, { "name":"MSIM_42620 mbtG; L-lysine N6-monooxygenase MbtG\tK04793 mbtG; mycobactin lysine-N-oxygenase" }, { "name":"MSIM_05540 glycosyl transferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]" } ] }, { "name":"01006 Prenyltransferases [BR:msim01006]", "children":[ { "name":"MSIM_08600 polyprenyl synthetase\tK13787 idsA; geranylgeranyl diphosphate synthase, type I [EC:2.5.1.1 2.5.1.10 2.5.1.29]" }, { "name":"MSIM_46150 idsA2; geranylgeranyl pyrophosphate synthase\tK13787 idsA; geranylgeranyl diphosphate synthase, type I [EC:2.5.1.1 2.5.1.10 2.5.1.29]" }, { "name":"MSIM_05620 hypothetical protein\tK13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]" }, { "name":"MSIM_37210 short-chain Z-isoprenyl diphosphate synthase\tK12503 uppS; short-chain Z-isoprenyl diphosphate synthase [EC:2.5.1.68]" }, { "name":"MSIM_08620 phytoene synthase\tK02291 crtB; 15-cis-phytoene synthase [EC:2.5.1.32]" }, { "name":"MSIM_05230 miaA; tRNA dimethylallyltransferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]" }, { "name":"MSIM_17150 menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase\tK02548 menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]" }, { "name":"MSIM_02290 ctaB; protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]" }, { "name":"MSIM_25930 decaprenyl-phosphate phosphoribosyltransferase\tK14136 K14136; decaprenyl-phosphate phosphoribosyltransferase [EC:2.4.2.45]" } ] }, { "name":"01007 Amino acid related enzymes [BR:msim01007]", "children":[ { "name":"MSIM_08220 gltX; glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]" }, { "name":"MSIM_54140 tyrS; tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]" }, { "name":"MSIM_14150 trpS; tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]" }, { "name":"MSIM_28890 cysS; cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]" }, { "name":"MSIM_39590 argS; arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]" }, { "name":"MSIM_36400 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]" }, { "name":"MSIM_01490 ileS; isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]" }, { "name":"MSIM_41780 valS; valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]" }, { "name":"MSIM_24480 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]" }, { "name":"MSIM_00380 lysX; lysylphosphatidylglycerol biosynthesis bifunctional protein LysX\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]" }, { "name":"MSIM_28690 lysS1; lysine--tRNA ligase 1\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]" }, { "name":"MSIM_03470 aspS; aspartate--tRNA(Asp\/Asn) ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]" }, { "name":"MSIM_03810 hisS; histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]" }, { "name":"MSIM_42880 glyQS; glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]" }, { "name":"MSIM_25730 serS; serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]" }, { "name":"MSIM_06380 proS; proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]" }, { "name":"MSIM_04190 thrS; threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]" }, { "name":"MSIM_03340 alaS; alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]" }, { "name":"MSIM_00300 pheS; phenylalanine--tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]" }, { "name":"MSIM_00290 pheT; phenylalanine--tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]" }, { "name":"MSIM_19330 aspC; putative aspartate aminotransferase\tK14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]" }, { "name":"MSIM_32630 N-succinyldiaminopimelate aminotransferase DapC\tK14267 dapC; N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17]" }, { "name":"MSIM_01000 hisC; histidinol-phosphate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_15470 aspartate aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_26310 pat; putative phenylalanine aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_45390 putative aminotransferase\tK00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]" }, { "name":"MSIM_01170 bioF1; 8-amino-7-oxononanoate synthase 1\tK00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]" }, { "name":"MSIM_44450 putative cystathionine beta-lyase\tK14155 patB; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]" }, { "name":"MSIM_43310 rocD; ornithine--oxo-acid transaminase\tK00819 rocD; ornithine--oxo-acid transaminase [EC:2.6.1.13]" }, { "name":"MSIM_00250 argD; acetylornithine aminotransferase\tK00821 argD; acetylornithine\/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]" }, { "name":"MSIM_03910 gabT; 4-aminobutyrate aminotransferase\tK07250 gabT; 4-aminobutyrate aminotransferase \/ (S)-3-amino-2-methylpropionate transaminase \/ 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48]" }, { "name":"MSIM_01180 bioA; adenosylmethionine-8-amino-7-oxononanoate aminotransferase\tK00833 bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]" }, { "name":"MSIM_17250 hemL; glutamate-1-semialdehyde 2,1-aminomutase\tK01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]" }, { "name":"MSIM_45740 ilvE; branched-chain-amino-acid aminotransferase\tK00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]" }, { "name":"MSIM_33010 serC; putative phosphoserine aminotransferase\tK00831 serC; phosphoserine aminotransferase [EC:2.6.1.52]" } ] }, { "name":"00199 Cytochrome P450 [BR:msim00199]", "children":[ { "name":"MSIM_30210 cytochrome P450\tK05917 CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]" }, { "name":"MSIM_44970 cyp124; methyl-branched lipid omega-hydroxylase\tK20497 CYP124; methyl-branched lipid omega-hydroxylase [EC:1.14.15.14]" }, { "name":"MSIM_21650 cytochrome P450\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_29340 cytochrome P450 steroid C27-monooxygenase\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_43540 cytochrome P450\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_50820 linalool 8-monooxygenase\tK15981 CYP125A; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]" }, { "name":"MSIM_38990 cyp130; cytochrome P450 130\tK21119 CYP130; cytochrome P450 family 130" }, { "name":"MSIM_23640 cyp135A1; putative cytochrome P450 135A1\tK24241 CYP135; cytochrome P450 family 135 [EC:1.14.-.-]" }, { "name":"MSIM_21890 cyp138; putative cytochrome P450 138\tK24192 CYP138; cytochrome P450 family 138 [EC:1.14.-.-]" }, { "name":"MSIM_29590 cyp142; putative cytochrome P450 142\tK16046 CYP142; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28]" }, { "name":"MSIM_48400 cytochrome P450\tK16046 CYP142; cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.28]" }, { "name":"MSIM_33880 cyp144_1; cytochrome P450 144\tK21200 CYP144; cytochrome P450 family 144" }, { "name":"MSIM_52280 cyp144_2; cytochrome P450 144\tK21200 CYP144; cytochrome P450 family 144" }, { "name":"MSIM_31990 cytochrome P450\tK23812 CYP150A5; cytochrome P450 family 150 subfamily A5 [EC:1.14.-.-]" } ] }, { "name":"00194 Photosynthesis proteins [BR:msim00194]", "children":[ { "name":"MSIM_31380 hypothetical protein\tK02639 petF; ferredoxin" }, { "name":"MSIM_39780 atpC; ATP synthase epsilon chain\tK02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon" }, { "name":"MSIM_39770 atpD; ATP synthase subunit beta\tK02112 ATPF1B; F-type H+\/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]" }, { "name":"MSIM_39760 atpG; ATP synthase gamma chain\tK02115 ATPF1G; F-type H+-transporting ATPase subunit gamma" }, { "name":"MSIM_39750 atpA; ATP synthase subunit alpha\tK02111 ATPF1A; F-type H+\/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]" }, { "name":"MSIM_39740 atpFH; ATP synthase subunit b-delta\tK02109 ATPF0B; F-type H+-transporting ATPase subunit b" }, { "name":"MSIM_39730 atpF; ATP synthase subunit b\tK02109 ATPF0B; F-type H+-transporting ATPase subunit b" }, { "name":"MSIM_39720 atpE; ATP synthase subunit c\tK02110 ATPF0C; F-type H+-transporting ATPase subunit c" }, { "name":"MSIM_39710 atpB; ATP synthase subunit a\tK02108 ATPF0A; F-type H+-transporting ATPase subunit a" } ] } ] }, { "name":"09182 Protein families: genetic information processing", "children":[ { "name":"03000 Transcription factors [BR:msim03000]", "children":[ { "name":"MSIM_39830 alkA; putative bifunctional transcriptional activator\/DNA repair enzyme AlkA\tK13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response \/ DNA-3-methyladenine glycosylase II [EC:3.2.2.21]" }, { "name":"MSIM_51130 oxyR; putative hydrogen peroxide-inducible genes activator\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator" }, { "name":"MSIM_24260 GntR family transcriptional regulator\tK02043 phnF; GntR family transcriptional regulator, phosphonate transport system regulatory protein" }, { "name":"MSIM_03190 putative GntR-family transcriptional regulator\tK03710 K03710; GntR family transcriptional regulator" }, { "name":"MSIM_22370 GntR family transcriptional regulator\tK03710 K03710; GntR family transcriptional regulator" }, { "name":"MSIM_23780 GntR family transcriptional regulator\tK03710 K03710; GntR family transcriptional regulator" }, { "name":"MSIM_22580 putative transcriptional regulator, TetR family protein\tK09017 rutR; TetR\/AcrR family transcriptional regulator" }, { "name":"MSIM_02710 TetR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon" }, { "name":"MSIM_10210 transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon" }, { "name":"MSIM_16760 TetR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon" }, { "name":"MSIM_43630 TetR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon" }, { "name":"MSIM_46470 transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon" }, { "name":"MSIM_04280 TetR family transcriptional regulator\tK21961 ethR; TetR\/AcrR family transcriptional regulator, ethionamide resistance regulator" }, { "name":"MSIM_25520 ethR; HTH-type transcriptional regulator EthR\tK21961 ethR; TetR\/AcrR family transcriptional regulator, ethionamide resistance regulator" }, { "name":"MSIM_41870 TetR family transcriptional regulator\tK21961 ethR; TetR\/AcrR family transcriptional regulator, ethionamide resistance regulator" }, { "name":"MSIM_02080 TetR family transcriptional regulator\tK21962 acnR; TetR\/AcrR family transcriptional regulator, transcriptional repressor of aconitase" }, { "name":"MSIM_29030 kstR; HTH-type transcriptional repressor KstR\tK22107 kstR; TetR\/AcrR family transcriptional regulator, cholesterol catabolism regulator" }, { "name":"MSIM_43560 putative transcriptional regulator, TetR family protein\tK22107 kstR; TetR\/AcrR family transcriptional regulator, cholesterol catabolism regulator" }, { "name":"MSIM_29230 TetR family transcriptional regulator\tK22108 kstR2; TetR\/AcrR family transcriptional regulator, cholesterol catabolism regulator" }, { "name":"MSIM_16100 mftR; putative mycofactocin biosynthesis transcriptional regulator MftR\tK24699 mftR; TetR\/AcrR family transcriptional regulator, regulator of mycofactocin system" }, { "name":"MSIM_23630 HTH-type transcriptional repressor\tK22295 K22295; TetR\/AcrR family transcriptional regulator, repressor for neighboring sulfatase" }, { "name":"MSIM_30310 hypothetical protein\tK22489 hosA; MarR family transcriptional regulator, temperature-dependent positive regulator of motility" }, { "name":"MSIM_31790 MarR family transcriptional regulator\tK23775 ohrR; MarR family transcriptional regulator, organic hydroperoxide resistance regulator" }, { "name":"MSIM_11730 hypothetical protein\tK13640 hspR; MerR family transcriptional regulator, heat shock protein HspR" }, { "name":"MSIM_19150 hspR; MerR family transcriptional regulator\tK13640 hspR; MerR family transcriptional regulator, heat shock protein HspR" }, { "name":"MSIM_06480 hypothetical protein\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator" }, { "name":"MSIM_07860 transcriptional repressor\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator" }, { "name":"MSIM_42860 furB; transcriptional repressor\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator" }, { "name":"MSIM_49970 furA; transcriptional regulator FurA\tK22297 furA; Fur family transcriptional regulator, stress-responsive regulator" }, { "name":"MSIM_06120 IclR family transcriptional regulator\tK13641 iclR; IclR family transcriptional regulator, acetate operon repressor" }, { "name":"MSIM_09030 iclR; IclR family transcriptional regulator\tK13641 iclR; IclR family transcriptional regulator, acetate operon repressor" }, { "name":"MSIM_09040 IclR family transcriptional regulator\tK13641 iclR; IclR family transcriptional regulator, acetate operon repressor" }, { "name":"MSIM_12860 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_27970 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_48380 hypothetical protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein" }, { "name":"MSIM_49350 transcriptional regulator\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor" }, { "name":"MSIM_51020 arsR; transcriptional regulator\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor" }, { "name":"MSIM_04620 cmtR; HTH-type transcriptional regulator CmtR\tK21885 cmtR; ArsR family transcriptional regulator, cadmium\/lead-responsive transcriptional repressor" }, { "name":"MSIM_35980 transcriptional regulator\tK21886 nmtR; ArsR family transcriptional regulator, nickel\/cobalt-responsive transcriptional repressor" }, { "name":"MSIM_42870 smtB; HTH-type transcriptional repressor SmtB\tK22298 smtB; ArsR family transcriptional regulator, zinc-responsive transcriptional repressor" }, { "name":"MSIM_37690 DNA-binding protein\tK21686 prpR; XRE family transcriptional regulator, fatty acid utilization regulator" }, { "name":"MSIM_17860 ramB; HTH-type transcriptional regulator RamB\tK07110 ramB; XRE family transcriptional regulator, fatty acid utilization regulator" }, { "name":"MSIM_05370 clgR; transcriptional regulator ClgR\tK27043 clgR; XRE family transcriptional regulator, stress-response regulator" }, { "name":"MSIM_05080 ideR; iron-dependent repressor IdeR\tK26252 dtxR; DtxR family transcriptional regulator, iron-dependent repressor" }, { "name":"MSIM_05940 sirR; transcriptional regulator\tK03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator" }, { "name":"MSIM_51660 blaI; transcriptional regulator BlaI\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor" }, { "name":"MSIM_13570 birA; biotin--[acetyl-CoA-carboxylase] ligase\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]" }, { "name":"MSIM_49430 siderophore-interacting protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR" }, { "name":"MSIM_25590 secretion protein EspR\tK27097 espR; ESX-1-secreted protein regulator" }, { "name":"MSIM_12320 whiB1; transcriptional regulator WhiB\tK18955 whiB1_2_3_4; WhiB family transcriptional regulator, redox-sensing transcriptional regulator" }, { "name":"MSIM_13060 hypothetical protein\tK18955 whiB1_2_3_4; WhiB family transcriptional regulator, redox-sensing transcriptional regulator" }, { "name":"MSIM_14690 whiB3; transcriptional regulator WhiB\tK18955 whiB1_2_3_4; WhiB family transcriptional regulator, redox-sensing transcriptional regulator" }, { "name":"MSIM_27890 whiB4; transcriptional regulator WhiB4\tK18955 whiB1_2_3_4; WhiB family transcriptional regulator, redox-sensing transcriptional regulator" }, { "name":"MSIM_24690 whiB5; transcriptional regulator WhiB\tK18956 whiB5; WhiB family transcriptional regulator, redox-sensing transcriptional regulator" }, { "name":"MSIM_25410 whiB6; transcriptional regulator WhiB\tK18957 whiB6; WhiB family transcriptional regulator, redox-sensing transcriptional regulator" }, { "name":"MSIM_12050 whiB7; putative transcriptional regulator WhiB7\tK18958 whiB7; WhiB family transcriptional regulator, redox-sensing transcriptional regulator" }, { "name":"MSIM_10330 csoR_1; copper-sensing transcriptional repressor CsoR\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor" }, { "name":"MSIM_21010 hypothetical protein\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor" }, { "name":"MSIM_48470 csoR_2; copper-sensing transcriptional repressor CsoR\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor" }, { "name":"MSIM_39160 embR_1; transcriptional regulatory protein EmbR\tK22894 embR; SARP family transcriptional regulator, regulator of embCAB operon" }, { "name":"MSIM_43890 embR_2; transcriptional regulatory protein EmbR\tK22894 embR; SARP family transcriptional regulator, regulator of embCAB operon" }, { "name":"MSIM_25180 parB; putative chromosome-partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein" }, { "name":"MSIM_28850 carD; RNA polymerase-binding transcription factor CarD\tK07736 carD; CarD family transcriptional regulator, regulator of rRNA transcription" }, { "name":"MSIM_00230 argR; arginine repressor\tK03402 argR; transcriptional regulator of arginine metabolism" }, { "name":"MSIM_42690 hrcA; heat-inducible transcription repressor HrcA\tK03705 hrcA; heat-inducible transcriptional repressor" }, { "name":"MSIM_16250 hypothetical protein\tK02616 paaX; phenylacetic acid degradation operon negative regulatory protein" }, { "name":"MSIM_02970 pyrR; bifunctional protein PyrR\tK02825 pyrR; pyrimidine operon attenuation protein \/ uracil phosphoribosyltransferase [EC:2.4.2.9]" }, { "name":"MSIM_24520 UPF0301 protein\tK07735 algH; putative transcriptional regulator" }, { "name":"MSIM_05160 nrdR; transcriptional repressor NrdR\tK07738 nrdR; transcriptional repressor NrdR" }, { "name":"MSIM_46200 mraZ; transcriptional regulator MraZ\tK03925 mraZ; transcriptional regulator MraZ" } ] }, { "name":"03021 Transcription machinery [BR:msim03021]", "children":[ { "name":"MSIM_32790 helicase\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]" }, { "name":"MSIM_15220 rpoA; DNA-directed RNA polymerase subunit alpha\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]" }, { "name":"MSIM_16300 rpoB; DNA-directed RNA polymerase subunit beta\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]" }, { "name":"MSIM_16290 rpoC; DNA-directed RNA polymerase subunit beta'\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]" }, { "name":"MSIM_02880 rpoZ; DNA-directed RNA polymerase subunit omega\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]" }, { "name":"MSIM_05000 sigA; RNA polymerase sigma factor SigA\tK03086 rpoD; RNA polymerase primary sigma factor" }, { "name":"MSIM_05070 sigB; RNA polymerase sigma factor SigB\tK03087 rpoS; RNA polymerase nonessential primary-like sigma factor" }, { "name":"MSIM_12370 sigH_1; ECF RNA polymerase sigma factor SigH\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_14070 sigJ; RNA polymerase sigma factor SigJ\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_14670 sigD; ECF RNA polymerase sigma factor SigD\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_15410 putative RNA polymerase sigma factor\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_15520 sigL; ECF RNA polymerase sigma factor SigL\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_16480 putative RNA polymerase sigma-70 factor\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_18030 sigK; ECF RNA polymerase sigma factor SigK\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_21090 sigG; RNA polymerase sigma factor\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_22450 rpoE; RNA polymerase sigma factor\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_25240 hypothetical protein\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_25430 putative alternative RNA polymerase SigI\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_36150 putative sigma factor\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_38690 sigE; ECF RNA polymerase sigma factor SigE\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_42660 RNA polymerase sigma factor\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_47520 hypothetical protein\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_48080 hypothetical protein\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_48360 sigH_2; ECF RNA polymerase sigma factor SigH\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_49410 sigH_3; ECF RNA polymerase sigma factor SigH\tK03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily" }, { "name":"MSIM_13660 sigF; RNA polymerase sigma factor SigF\tK03090 sigB; RNA polymerase sigma-B factor" }, { "name":"MSIM_52600 alternative sigma factor SigF\tK03090 sigB; RNA polymerase sigma-B factor" }, { "name":"MSIM_06340 nusA; transcription termination\/antitermination protein NusA\tK02600 nusA; transcription termination\/antitermination protein NusA" }, { "name":"MSIM_03220 nusB; N utilization substance protein B\tK03625 nusB; transcription antitermination protein NusB" }, { "name":"MSIM_16510 nusG; transcription termination\/antitermination protein NusG\tK02601 nusG; transcription termination\/antitermination protein NusG" }, { "name":"MSIM_27710 serine\/threonine protein kinase\tK17752 rsbT; serine\/threonine-protein kinase RsbT [EC:2.7.11.1]" }, { "name":"MSIM_27720 rsbS; RsbT antagonist protein RsbS\tK17762 rsbS; rsbT antagonist protein RsbS" }, { "name":"MSIM_27730 anti-sigma factor antagonist\tK17763 rsbR; rsbT co-antagonist protein RsbR" }, { "name":"MSIM_37150 hypothetical protein\tK03624 greA; transcription elongation factor GreA" }, { "name":"MSIM_39640 rho; transcription termination factor Rho\tK03628 rho; transcription termination factor Rho" } ] }, { "name":"03019 Messenger RNA biogenesis [BR:msim03019]", "children":[ { "name":"MSIM_41820 ribonuclease\tK08300 rne; ribonuclease E [EC:3.1.26.12]" }, { "name":"MSIM_07670 rnc; ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]" }, { "name":"MSIM_05440 rnj; ribonuclease J\tK12574 rnj; ribonuclease J [EC:3.1.-.-]" }, { "name":"MSIM_41200 orn; oligoribonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]" }, { "name":"MSIM_38950 deaD; ATP-dependent RNA helicase DeaD\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]" }, { "name":"MSIM_43790 recQ; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]" }, { "name":"MSIM_36760 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"MSIM_05890 pnp; polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]" }, { "name":"MSIM_39640 rho; transcription termination factor Rho\tK03628 rho; transcription termination factor Rho" }, { "name":"MSIM_19180 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"MSIM_14830 groL1; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_18110 groL_1; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_49500 groL_2; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_08150 ppk; polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]" }, { "name":"MSIM_12750 ppk2; polyphosphate kinase\tK22468 ppk2; polyphosphate kinase [EC:2.7.4.34]" }, { "name":"MSIM_25540 rraA; putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase\tK02553 rraA; regulator of ribonuclease activity A" }, { "name":"MSIM_02490 nucleotide-binding protein\tK06958 rapZ; RNase adapter protein RapZ" }, { "name":"MSIM_47270 helY; putative helicase HelY\tK03727 helY; ATP-dependent RNA helicase HelY [EC:5.6.2.6]" } ] }, { "name":"03041 Spliceosome" }, { "name":"03011 Ribosome [BR:msim03011]", "children":[ { "name":"MSIM_00660 rpsA; 30S ribosomal protein S1\tK02945 RP-S1; small subunit ribosomal protein S1" }, { "name":"MSIM_06960 rpsB; 30S ribosomal protein S2\tK02967 RP-S2; small subunit ribosomal protein S2" }, { "name":"MSIM_15920 rpsC; 30S ribosomal protein S3\tK02982 RP-S3; small subunit ribosomal protein S3" }, { "name":"MSIM_15230 rpsD; 30S ribosomal protein S4\tK02986 RP-S4; small subunit ribosomal protein S4" }, { "name":"MSIM_15750 rpsE; 30S ribosomal protein S5\tK02988 RP-S5; small subunit ribosomal protein S5" }, { "name":"MSIM_24170 rpsF; 30S ribosomal protein S6\tK02990 RP-S6; small subunit ribosomal protein S6" }, { "name":"MSIM_16190 rpsG; 30S ribosomal protein S7\tK02992 RP-S7; small subunit ribosomal protein S7" }, { "name":"MSIM_15780 rpsH; 30S ribosomal protein S8\tK02994 RP-S8; small subunit ribosomal protein S8" }, { "name":"MSIM_15070 rpsI; 30S ribosomal protein S9\tK02996 RP-S9; small subunit ribosomal protein S9" }, { "name":"MSIM_15990 rpsJ; 30S ribosomal protein S10\tK02946 RP-S10; small subunit ribosomal protein S10" }, { "name":"MSIM_15240 rpsK; 30S ribosomal protein S11\tK02948 RP-S11; small subunit ribosomal protein S11" }, { "name":"MSIM_16200 rpsL; 30S ribosomal protein S12\tK02950 RP-S12; small subunit ribosomal protein S12" }, { "name":"MSIM_15250 rpsM; 30S ribosomal protein S13\tK02952 RP-S13; small subunit ribosomal protein S13" }, { "name":"MSIM_15790 rpsZ; 30S ribosomal protein S14 type Z\tK02954 RP-S14; small subunit ribosomal protein S14" }, { "name":"MSIM_22520 rpsN; 30S ribosomal protein S14\tK02954 RP-S14; small subunit ribosomal protein S14" }, { "name":"MSIM_05900 rpsO; 30S ribosomal protein S15\tK02956 RP-S15; small subunit ribosomal protein S15" }, { "name":"MSIM_07400 rpsP; 30S ribosomal protein S16\tK02959 RP-S16; small subunit ribosomal protein S16" }, { "name":"MSIM_15890 rpsQ; 30S ribosomal protein S17\tK02961 RP-S17; small subunit ribosomal protein S17" }, { "name":"MSIM_22530 rpsR2; 30S ribosomal protein S18 2\tK02963 RP-S18; small subunit ribosomal protein S18" }, { "name":"MSIM_24150 rpsR; 30S ribosomal protein S18\tK02963 RP-S18; small subunit ribosomal protein S18" }, { "name":"MSIM_15940 rpsS; 30S ribosomal protein S19\tK02965 RP-S19; small subunit ribosomal protein S19" }, { "name":"MSIM_42230 rpsT; 30S ribosomal protein S20\tK02968 RP-S20; small subunit ribosomal protein S20" }, { "name":"MSIM_16490 rplA; 50S ribosomal protein L1\tK02863 RP-L1; large subunit ribosomal protein L1" }, { "name":"MSIM_15950 rplB; 50S ribosomal protein L2\tK02886 RP-L2; large subunit ribosomal protein L2" }, { "name":"MSIM_15980 rplC; 50S ribosomal protein L3\tK02906 RP-L3; large subunit ribosomal protein L3" }, { "name":"MSIM_15970 rplD; 50S ribosomal protein L4\tK02926 RP-L4; large subunit ribosomal protein L4" }, { "name":"MSIM_15800 rplE; 50S ribosomal protein L5\tK02931 RP-L5; large subunit ribosomal protein L5" }, { "name":"MSIM_15770 rplF; 50S ribosomal protein L6\tK02933 RP-L6; large subunit ribosomal protein L6" }, { "name":"MSIM_24140 rplI; 50S ribosomal protein L9\tK02939 RP-L9; large subunit ribosomal protein L9" }, { "name":"MSIM_16350 rplJ; 50S ribosomal protein L10\tK02864 RP-L10; large subunit ribosomal protein L10" }, { "name":"MSIM_16500 rplK; 50S ribosomal protein L11\tK02867 RP-L11; large subunit ribosomal protein L11" }, { "name":"MSIM_16340 rplL; 50S ribosomal protein L7\/L12\tK02935 RP-L7; large subunit ribosomal protein L7\/L12" }, { "name":"MSIM_15080 rplM; 50S ribosomal protein L13\tK02871 RP-L13; large subunit ribosomal protein L13" }, { "name":"MSIM_15820 rplN; 50S ribosomal protein L14\tK02874 RP-L14; large subunit ribosomal protein L14" }, { "name":"MSIM_15730 rplO; 50S ribosomal protein L15\tK02876 RP-L15; large subunit ribosomal protein L15" }, { "name":"MSIM_15910 rplP; 50S ribosomal protein L16\tK02878 RP-L16; large subunit ribosomal protein L16" }, { "name":"MSIM_15210 hypothetical protein\tK02879 RP-L17; large subunit ribosomal protein L17" }, { "name":"MSIM_15760 rplR; 50S ribosomal protein L18\tK02881 RP-L18; large subunit ribosomal protein L18" }, { "name":"MSIM_07350 rplS; 50S ribosomal protein L19\tK02884 RP-L19; large subunit ribosomal protein L19" }, { "name":"MSIM_00350 rplT; 50S ribosomal protein L20\tK02887 RP-L20; large subunit ribosomal protein L20" }, { "name":"MSIM_41830 rplU; 50S ribosomal protein L21\tK02888 RP-L21; large subunit ribosomal protein L21" }, { "name":"MSIM_15930 rplV; 50S ribosomal protein L22\tK02890 RP-L22; large subunit ribosomal protein L22" }, { "name":"MSIM_15960 rplW; 50S ribosomal protein L23\tK02892 RP-L23; large subunit ribosomal protein L23" }, { "name":"MSIM_15810 rplX; 50S ribosomal protein L24\tK02895 RP-L24; large subunit ribosomal protein L24" }, { "name":"MSIM_41840 rpmA; 50S ribosomal protein L27\tK02899 RP-L27; large subunit ribosomal protein L27" }, { "name":"MSIM_08050 50S ribosomal protein L28\tK02902 RP-L28; large subunit ribosomal protein L28" }, { "name":"MSIM_22500 rpmB2; 50S ribosomal protein L28-2\tK02902 RP-L28; large subunit ribosomal protein L28" }, { "name":"MSIM_15900 rpmC; 50S ribosomal protein L29\tK02904 RP-L29; large subunit ribosomal protein L29" }, { "name":"MSIM_15740 rpmD; 50S ribosomal protein L30\tK02907 RP-L30; large subunit ribosomal protein L30" }, { "name":"MSIM_39650 rpmE; 50S ribosomal protein L31\tK02909 RP-L31; large subunit ribosomal protein L31" }, { "name":"MSIM_34910 rpmF; 50S ribosomal protein L32\tK02911 RP-L32; large subunit ribosomal protein L32" }, { "name":"MSIM_16560 rpmG2; 50S ribosomal protein L33 2\tK02913 RP-L33; large subunit ribosomal protein L33" }, { "name":"MSIM_22510 rpmG1; 50S ribosomal protein L33 1\tK02913 RP-L33; large subunit ribosomal protein L33" }, { "name":"MSIM_25110 rpmH; 50S ribosomal protein L34\tK02914 RP-L34; large subunit ribosomal protein L34" }, { "name":"MSIM_00360 rpmI; 50S ribosomal protein L35\tK02916 RP-L35; large subunit ribosomal protein L35" }, { "name":"MSIM_36470 rplY; 50S ribosomal protein L25\tK02897 RP-L25; large subunit ribosomal protein L25" }, { "name":"MSIM_r00020 23S ribosomal RNA\tK01980 23SrRNA; 23S ribosomal RNA" }, { "name":"MSIM_r00030 5S ribosomal RNA\tK01985 5SrRNA; 5S ribosomal RNA" } ] }, { "name":"03009 Ribosome biogenesis [BR:msim03009]", "children":[ { "name":"MSIM_07670 rnc; ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]" }, { "name":"MSIM_41200 orn; oligoribonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]" }, { "name":"MSIM_42770 era; GTPase Era\tK03595 era; GTPase" }, { "name":"MSIM_41850 obg; GTPase Obg\tK03979 obgE; GTPase [EC:3.6.5.-]" }, { "name":"MSIM_06340 nusA; transcription termination\/antitermination protein NusA\tK02600 nusA; transcription termination\/antitermination protein NusA" }, { "name":"MSIM_03220 nusB; N utilization substance protein B\tK03625 nusB; transcription antitermination protein NusB" }, { "name":"MSIM_16510 nusG; transcription termination\/antitermination protein NusG\tK02601 nusG; transcription termination\/antitermination protein NusG" }, { "name":"MSIM_36430 ksgA; ribosomal RNA small subunit methyltransferase A\tK02528 ksgA; 16S rRNA (adenine1518-N6\/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]" }, { "name":"MSIM_02630 putative methyltransferase\tK03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]" }, { "name":"MSIM_07940 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD\tK08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]" }, { "name":"MSIM_42710 rsmE; ribosomal RNA small subunit methyltransferase E\tK09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]" }, { "name":"MSIM_25160 rsmG; ribosomal RNA small subunit methyltransferase G\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]" }, { "name":"MSIM_46210 rsmH; ribosomal RNA small subunit methyltransferase H\tK03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]" }, { "name":"MSIM_36130 rsmI; ribosomal RNA small subunit methyltransferase I\tK07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]" }, { "name":"MSIM_54080 tlyA; 16S\/23S rRNA (cytidine-2'-O)-methyltransferase\tK06442 tlyA; 23S rRNA (cytidine1920-2'-O)\/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]" }, { "name":"MSIM_28900 putative tRNA\/rRNA methyltransferase\tK03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]" }, { "name":"MSIM_06830 rlmN; putative dual-specificity RNA methyltransferase RlmN\tK06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]" }, { "name":"MSIM_13770 hypothetical protein\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]" }, { "name":"MSIM_53960 putative RNA pseudouridine synthase\tK06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]" }, { "name":"MSIM_01420 putative RNA pseudouridine synthase\tK06180 rluD; 23S rRNA pseudouridine1911\/1915\/1917 synthase [EC:5.4.99.23]" }, { "name":"MSIM_14860 rimI; ribosomal-protein-alanine acetyltransferase\tK03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase \/ [ribosomal protein L31]-L-lysine N-acetyltransferase [EC:2.3.1.266 2.3.1.338]" }, { "name":"MSIM_35020 rimJ; N-acetyltransferase GCN5\tK03790 rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267]" }, { "name":"MSIM_07380 rimM; ribosome maturation factor RimM\tK02860 rimM; 16S rRNA processing protein RimM" }, { "name":"MSIM_41820 ribonuclease\tK08300 rne; ribonuclease E [EC:3.1.26.12]" }, { "name":"MSIM_03330 putative pre-16S rRNA nuclease\tK07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-]" }, { "name":"MSIM_38950 deaD; ATP-dependent RNA helicase DeaD\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]" }, { "name":"MSIM_12500 ribosome small subunit-dependent GTPase A\tK06949 rsgA; ribosome biogenesis GTPase \/ thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]" }, { "name":"MSIM_53940 der; GTPase Der\tK03977 engA; GTPase" }, { "name":"MSIM_05210 hflX; GTPase HflX\tK03665 hflX; GTPase" }, { "name":"MSIM_39680 putative threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]" }, { "name":"MSIM_03850 relA; putative GTP pyrophosphokinase\tK01139 spoT; GTP diphosphokinase \/ guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]" }, { "name":"MSIM_06310 rbfA; ribosome-binding factor A\tK02834 rbfA; ribosome-binding factor A" }, { "name":"MSIM_06350 rimP; ribosome maturation factor RimP\tK09748 rimP; ribosome maturation factor RimP" }, { "name":"MSIM_42060 rsfS; ribosomal silencing factor RsfS\tK09710 ybeB; ribosome-associated protein" }, { "name":"MSIM_42730 ybeY; endoribonuclease YbeY\tK07042 ybeY; probable rRNA maturation factor" }, { "name":"MSIM_37450 ychF; ribosome-binding ATPase YchF\tK06942 ychF; ribosome-binding ATPase" }, { "name":"MSIM_07680 hypothetical protein\tK07040 yceD; DUF177 domain-containing protein" } ] }, { "name":"03016 Transfer RNA biogenesis [BR:msim03016]", "children":[ { "name":"MSIM_42270 rnz; ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]" }, { "name":"MSIM_25300 pcnA; CCA tRNA nucleotidyltransferase\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]" }, { "name":"MSIM_08220 gltX; glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]" }, { "name":"MSIM_06380 proS; proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]" }, { "name":"MSIM_01490 ileS; isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]" }, { "name":"MSIM_24480 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]" }, { "name":"MSIM_36400 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]" }, { "name":"MSIM_39590 argS; arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]" }, { "name":"MSIM_00380 lysX; lysylphosphatidylglycerol biosynthesis bifunctional protein LysX\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]" }, { "name":"MSIM_28690 lysS1; lysine--tRNA ligase 1\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]" }, { "name":"MSIM_03470 aspS; aspartate--tRNA(Asp\/Asn) ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]" }, { "name":"MSIM_03340 alaS; alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]" }, { "name":"MSIM_42880 glyQS; glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]" }, { "name":"MSIM_04190 thrS; threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]" }, { "name":"MSIM_25730 serS; serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]" }, { "name":"MSIM_28890 cysS; cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]" }, { "name":"MSIM_41780 valS; valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]" }, { "name":"MSIM_03810 hisS; histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]" }, { "name":"MSIM_00300 pheS; phenylalanine--tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]" }, { "name":"MSIM_00290 pheT; phenylalanine--tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]" }, { "name":"MSIM_54140 tyrS; tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]" }, { "name":"MSIM_14150 trpS; tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]" }, { "name":"MSIM_50710 dtd; D-aminoacyl-tRNA deacylase\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]" }, { "name":"MSIM_39070 hydrolase\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]" }, { "name":"MSIM_05280 miaB; tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]" }, { "name":"MSIM_47110 trmI; tRNA (adenine(58)-N(1))-methyltransferase TrmI\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]" }, { "name":"MSIM_20770 trmB; tRNA (guanine-N(7)-)-methyltransferase\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]" }, { "name":"MSIM_15200 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]" }, { "name":"MSIM_05980 truB; tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]" }, { "name":"MSIM_08500 iscS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]" }, { "name":"MSIM_39680 putative threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]" }, { "name":"MSIM_05230 miaA; tRNA dimethylallyltransferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]" }, { "name":"MSIM_23320 selD; selenide, water dikinase\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]" }, { "name":"MSIM_44420 3'(2'),5'-bisphosphate nucleotidase CysQ\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]" }, { "name":"MSIM_46860 cysQ; 3'-phosphoadenosine 5'-phosphate phosphatase\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]" }, { "name":"MSIM_25120 rnpA; ribonuclease P protein component\tK03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]" }, { "name":"MSIM_40030 rph; ribonuclease PH\tK00989 rph; ribonuclease PH [EC:2.7.7.56]" }, { "name":"MSIM_04830 ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]" }, { "name":"MSIM_41510 energy-dependent translational throttle protein EttA\tK06020 ettA; energy-dependent translational throttle protein EttA" }, { "name":"MSIM_12390 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase\tK03976 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]" }, { "name":"MSIM_26570 tadA; tRNA-specific adenosine deaminase\tK11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]" }, { "name":"MSIM_07370 trmD; tRNA (guanine-N(1)-)-methyltransferase\tK00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]" }, { "name":"MSIM_14390 spoU; putative tRNA (cytidine(34)-2'-O)-methyltransferase\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]" }, { "name":"MSIM_00340 tsnR; RNA methyltransferase\tK03437 spoU; RNA methyltransferase, TrmH family" }, { "name":"MSIM_13770 hypothetical protein\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]" }, { "name":"MSIM_08490 mnmA; tRNA-specific 2-thiouridylase MnmA\tK00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]" }, { "name":"MSIM_30900 folate-binding protein YgfZ\tK06980 ygfZ; tRNA-modifying protein YgfZ" }, { "name":"MSIM_28390 tilS; tRNA(Ile)-lysidine synthase\tK04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]" }, { "name":"MSIM_14870 hypothetical protein\tK14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB" }, { "name":"MSIM_14850 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase\tK25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]" }, { "name":"MSIM_14880 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE\tK06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE" }, { "name":"MSIM_05890 pnp; polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]" } ] }, { "name":"03012 Translation factors [BR:msim03012]", "children":[ { "name":"MSIM_06320 hypothetical protein\tK02519 infB; translation initiation factor IF-2" }, { "name":"MSIM_00370 infC; translation initiation factor IF-3\tK02520 infC; translation initiation factor IF-3" }, { "name":"MSIM_06950 tsf; elongation factor Ts\tK02357 tsf; elongation factor Ts" }, { "name":"MSIM_16170 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu" }, { "name":"MSIM_16180 fusA; elongation factor G\tK02355 fusA; elongation factor G" }, { "name":"MSIM_22180 elongation factor G-like protein\tK02355 fusA; elongation factor G" }, { "name":"MSIM_23300 selenocysteine-specific translation elongation factor\tK03833 selB; selenocysteine-specific elongation factor" }, { "name":"MSIM_39660 prfA; peptide chain release factor 1\tK02835 prfA; peptide chain release factor 1" }, { "name":"MSIM_06850 frr; ribosome-recycling factor\tK02838 frr; ribosome recycling factor" }, { "name":"MSIM_27660 methylase\tK02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297]" }, { "name":"MSIM_39670 prmC; release factor glutamine methyltransferase\tK02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297]" }, { "name":"MSIM_36460 pth; peptidyl-tRNA hydrolase\tK01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]" }, { "name":"MSIM_15260 infA; translation initiation factor IF-1\tK02518 infA; translation initiation factor IF-1" }, { "name":"MSIM_03230 efp; elongation factor P\tK02356 efp; elongation factor P" }, { "name":"MSIM_10750 prfB; peptide chain release factor 2\tK02836 prfB; peptide chain release factor 2" } ] }, { "name":"03110 Chaperones and folding catalysts [BR:msim03110]", "children":[ { "name":"MSIM_19110 clpB; chaperone protein ClpB\tK03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB" }, { "name":"MSIM_28710 clpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1\tK03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC" }, { "name":"MSIM_41710 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX\tK03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX" }, { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" }, { "name":"MSIM_19180 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"MSIM_14830 groL1; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_18110 groL_1; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_49500 groL_2; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_19160 dnaJ1; chaperone protein DnaJ 1\tK03686 dnaJ; molecular chaperone DnaJ" }, { "name":"MSIM_42700 dnaJ2; chaperone protein DnaJ 2\tK03686 dnaJ; molecular chaperone DnaJ" }, { "name":"MSIM_19170 grpE; protein GrpE\tK03687 GRPE; molecular chaperone GrpE" }, { "name":"MSIM_11740 hsp18; 18 kDa antigen\tK13993 HSP20; HSP20 family protein" }, { "name":"MSIM_20130 hsp; heat-shock protein Hsp20\tK13993 HSP20; HSP20 family protein" }, { "name":"MSIM_23940 18 kDa antigen (HSP 16.7)\tK13993 HSP20; HSP20 family protein" }, { "name":"MSIM_14840 groS; 10 kDa chaperonin\tK04078 groES; chaperonin GroES" }, { "name":"MSIM_38710 htrA; serine protease HtrA\tK04771 degP; serine protease Do [EC:3.4.21.107]" }, { "name":"MSIM_28580 ftsH; ATP-dependent zinc metalloprotease FtsH\tK03798 ftsH; cell division protease FtsH [EC:3.4.24.-]" }, { "name":"MSIM_39710 atpB; ATP synthase subunit a\tK02108 ATPF0A; F-type H+-transporting ATPase subunit a" }, { "name":"MSIM_20730 hypothetical protein\tK19777 hdeA; acid stress chaperone HdeA" }, { "name":"MSIM_06500 hypA; hydrogenase expression protein HupH\tK04651 hypA; hydrogenase nickel incorporation protein HypA\/HybF" }, { "name":"MSIM_53410 hypB; hydrogenase nickel incorporation protein HypB\tK04652 hypB; hydrogenase nickel incorporation protein HypB" }, { "name":"MSIM_13300 putative protease\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_15140 mycP4; mycosin-4\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_19790 type VII secretion-associated serine protease\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_25370 membrane-anchored mycosin\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_52070 hypothetical protein\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_25000 ppiA; peptidyl-prolyl cis-trans isomerase A\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]" }, { "name":"MSIM_03830 ppiB; putative peptidyl-prolyl cis-trans isomerase B\tK03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]" }, { "name":"MSIM_25210 trxA; thioredoxin\tK03671 TXN; thioredoxin" }, { "name":"MSIM_39900 hypothetical protein\tK05838 ybbN; putative thioredoxin" } ] }, { "name":"04131 Membrane trafficking [BR:msim04131]", "children":[ { "name":"MSIM_41810 ndkA; nucleoside diphosphate kinase\tK00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]" }, { "name":"MSIM_26160 flotillin family protein\tK07192 FLOT; flotillin" }, { "name":"MSIM_25600 UPF0016 family membrane protein\tK23541 TMEM165; Ca2+\/H+ antiporter, TMEM165\/GDT1 family" }, { "name":"MSIM_46020 hypothetical protein\tK01551 arsA; arsenite\/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_02410 gap; glyceraldehyde-3-phosphate dehydrogenase\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]" }, { "name":"MSIM_17650 gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]" }, { "name":"MSIM_00810 pykA; pyruvate kinase\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_06140 hypothetical protein\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" }, { "name":"MSIM_41230 MFS transporter\tK06902 UMF1; MFS transporter, UMF1 family" } ] }, { "name":"04121 Ubiquitin system [BR:msim04121]", "children":[ { "name":"MSIM_47190 pup; prokaryotic ubiquitin-like protein Pup\tK13570 pup; prokaryotic ubiquitin-like protein Pup" } ] }, { "name":"03051 Proteasome [BR:msim03051]", "children":[ { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" }, { "name":"MSIM_47210 prcA; proteasome subunit alpha\tK03432 psmA; proteasome alpha subunit [EC:3.4.25.1]" }, { "name":"MSIM_47200 prcB; proteasome subunit beta\tK03433 psmB; proteasome beta subunit [EC:3.4.25.1]" }, { "name":"MSIM_47150 mpa; proteasome-associated ATPase\tK13527 mpa; proteasome-associated ATPase" }, { "name":"MSIM_47220 pafA; Pup--protein ligase\tK13571 pafA; proteasome accessory factor A [EC:6.3.1.19]" }, { "name":"MSIM_47230 pafB; protein PafB\tK13572 pafB; proteasome accessory factor B" }, { "name":"MSIM_47240 protein pafC\tK13573 pafC; proteasome accessory factor C" }, { "name":"MSIM_47180 proteasome accessory factor PafA2\tK20814 dop; Pup amidohydrolase [EC:3.5.1.119]" } ] }, { "name":"03032 DNA replication proteins [BR:msim03032]", "children":[ { "name":"MSIM_08170 hypothetical protein\tK03530 hupB; DNA-binding protein HU-beta" }, { "name":"MSIM_25100 dnaA; chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein" }, { "name":"MSIM_24130 replicative DNA helicase\tK02314 dnaB; replicative DNA helicase [EC:5.6.2.3]" }, { "name":"MSIM_42960 dnaG; DNA primase\tK02316 dnaG; DNA primase [EC:2.7.7.101]" }, { "name":"MSIM_24160 ssb; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_41500 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_01360 dnaE1; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]" }, { "name":"MSIM_25090 dnaN; DNA polymerase III subunit beta\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]" }, { "name":"MSIM_42220 hypothetical protein\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]" }, { "name":"MSIM_28280 DNA polymerase\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]" }, { "name":"MSIM_27330 dnaQ; DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_45940 hypothetical protein\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_27190 DNA polymerase III, subunit gamma\/tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]" }, { "name":"MSIM_45420 hypothetical protein\tK22316 rhnA-cobC; ribonuclease H \/ adenosylcobalamin\/alpha-ribazole phosphatase [EC:3.1.26.4 3.1.3.73]" }, { "name":"MSIM_07330 rnhB; ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]" }, { "name":"MSIM_00680 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]" }, { "name":"MSIM_08450 ligA; DNA ligase A\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]" }, { "name":"MSIM_25050 gyrA; DNA gyrase subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]" }, { "name":"MSIM_23760 gyrB_1; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]" }, { "name":"MSIM_25060 gyrB_2; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]" }, { "name":"MSIM_11260 DNA topoisomerase\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]" }, { "name":"MSIM_28260 topA; DNA topoisomerase 1\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]" } ] }, { "name":"03036 Chromosome and associated proteins [BR:msim03036]", "children":[ { "name":"MSIM_07670 rnc; ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_26160 flotillin family protein\tK07192 FLOT; flotillin" }, { "name":"MSIM_28700 lsr2; nucleoid-associated protein Lsr2\tK26249 lsr2; nucleoid-associated protein Lsr2" }, { "name":"MSIM_08170 hypothetical protein\tK03530 hupB; DNA-binding protein HU-beta" }, { "name":"MSIM_25100 dnaA; chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein" }, { "name":"MSIM_21810 dps; DNA protection during starvation protein\tK04047 dps; starvation-inducible DNA-binding protein" }, { "name":"MSIM_07600 smc; chromosome partition protein Smc\tK03529 smc; chromosome segregation protein" }, { "name":"MSIM_53980 segregation\/condensation protein A\tK05896 scpA; segregation and condensation protein A" }, { "name":"MSIM_53970 hypothetical protein\tK06024 scpB; segregation and condensation protein B" }, { "name":"MSIM_10720 ftsE; cell division ATP-binding protein FtsE\tK09812 ftsE; cell division transport system ATP-binding protein" }, { "name":"MSIM_46230 pbpB; penicillin-binding protein 2\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]" }, { "name":"MSIM_05400 ftsK; DNA translocase FtsK\tK03466 ftsK; DNA segregation ATPase FtsK\/SpoIIIE, S-DNA-T family" }, { "name":"MSIM_46340 ftsQ; cell division protein FtsQ\tK03589 ftsQ; cell division protein FtsQ" }, { "name":"MSIM_24920 rodA; putative FtsW-like protein\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_46310 ftsW; cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_10710 ftsX; cell division protein FtsX\tK09811 ftsX; cell division transport system permease protein" }, { "name":"MSIM_46350 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ" }, { "name":"MSIM_04700 cell division protein ZapE\tK06916 zapE; cell division protein ZapE" }, { "name":"MSIM_25200 cwlM; N-acetylmuramoyl-L-alanine amidase CwlM\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_27270 N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_44940 hypothetical protein\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]" }, { "name":"MSIM_46380 sepF; cell division protein SepF\tK09772 sepF; cell division inhibitor SepF" }, { "name":"MSIM_12260 chromosome partitioning protein ParA\tK03496 parA; chromosome partitioning protein" }, { "name":"MSIM_25170 parA; chromosome partitioning protein ParA\tK03496 parA; chromosome partitioning protein" }, { "name":"MSIM_53990 hypothetical protein\tK03496 parA; chromosome partitioning protein" }, { "name":"MSIM_25180 parB; putative chromosome-partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein" }, { "name":"MSIM_25160 rsmG; ribosomal RNA small subunit methyltransferase G\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]" }, { "name":"MSIM_06980 xerC_1; tyrosine recombinase XerC\tK03733 xerC; integrase\/recombinase XerC" }, { "name":"MSIM_07090 xerC_2; tyrosine recombinase XerC\tK04763 xerD; integrase\/recombinase XerD" }, { "name":"MSIM_54010 xerD; tyrosine recombinase XerD\tK04763 xerD; integrase\/recombinase XerD" }, { "name":"MSIM_38730 mrp; iron-sulfur cluster carrier protein\tK03593 mrp; ATP-binding protein involved in chromosome partitioning" }, { "name":"MSIM_02470 whiA; putative sporulation transcription regulator WhiA\tK09762 whiA; cell division protein WhiA" } ] }, { "name":"03400 DNA repair and recombination proteins [BR:msim03400]", "children":[ { "name":"MSIM_39820 ogt; methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]" }, { "name":"MSIM_08720 deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]" }, { "name":"MSIM_08090 ung; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]" }, { "name":"MSIM_54150 putative 3-methyladenine DNA glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]" }, { "name":"MSIM_28790 mutY; A\/G-specific adenine glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]" }, { "name":"MSIM_27990 nth; endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]" }, { "name":"MSIM_32790 helicase\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]" }, { "name":"MSIM_18560 mutT3; putative 8-oxo-dGTP diphosphatase 3\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]" }, { "name":"MSIM_38210 mutT2; 8-oxo-dGTP diphosphatase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]" }, { "name":"MSIM_04940 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]" }, { "name":"MSIM_33180 mug; G\/U mismatch-specific DNA glycosylase\tK03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]" }, { "name":"MSIM_11580 uracil-DNA glycosylase\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]" }, { "name":"MSIM_39020 hypothetical protein\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]" }, { "name":"MSIM_39830 alkA; putative bifunctional transcriptional activator\/DNA repair enzyme AlkA\tK13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response \/ DNA-3-methyladenine glycosylase II [EC:3.2.2.21]" }, { "name":"MSIM_38600 tagA; DNA-3-methyladenine glycosylase I\tK01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]" }, { "name":"MSIM_00640 mutM_1; formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]" }, { "name":"MSIM_07660 mutM_2; formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]" }, { "name":"MSIM_34640 putative formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]" }, { "name":"MSIM_13720 nei2; endonuclease 8 2\tK05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]" }, { "name":"MSIM_41640 nei1; endonuclease 8 1\tK05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]" }, { "name":"MSIM_18340 xthA; exodeoxyribonuclease III\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]" }, { "name":"MSIM_16280 deoxyribonuclease IV\tK01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]" }, { "name":"MSIM_08450 ligA; DNA ligase A\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]" }, { "name":"MSIM_00680 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]" }, { "name":"MSIM_00490 uvrA; UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A" }, { "name":"MSIM_00560 uvrB; UvrABC system protein B\tK03702 uvrB; excinuclease ABC subunit B" }, { "name":"MSIM_02500 uvrC; UvrABC system protein C\tK03703 uvrC; excinuclease ABC subunit C" }, { "name":"MSIM_12070 uvrD2; ATP-dependent DNA helicase UvrD2\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_12110 ATP-dependent DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_34690 uvrD1; ATP-dependent DNA helicase UvrD1\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]" }, { "name":"MSIM_16300 rpoB; DNA-directed RNA polymerase subunit beta\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]" }, { "name":"MSIM_16290 rpoC; DNA-directed RNA polymerase subunit beta'\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]" }, { "name":"MSIM_15220 rpoA; DNA-directed RNA polymerase subunit alpha\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]" }, { "name":"MSIM_02880 rpoZ; DNA-directed RNA polymerase subunit omega\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]" }, { "name":"MSIM_36720 mfd; transcription-repair-coupling factor\tK03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]" }, { "name":"MSIM_37410 xseA; exodeoxyribonuclease 7 large subunit\tK03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]" }, { "name":"MSIM_37400 xseB; exodeoxyribonuclease 7 small subunit\tK03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]" }, { "name":"MSIM_01360 dnaE1; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]" }, { "name":"MSIM_25090 dnaN; DNA polymerase III subunit beta\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]" }, { "name":"MSIM_42220 hypothetical protein\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]" }, { "name":"MSIM_28280 DNA polymerase\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]" }, { "name":"MSIM_27330 dnaQ; DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_45940 hypothetical protein\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]" }, { "name":"MSIM_27190 DNA polymerase III, subunit gamma\/tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]" }, { "name":"MSIM_24160 ssb; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_41500 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_05300 recA; protein RecA\tK03553 recA; recombination protein RecA" }, { "name":"MSIM_03960 ruvA; Holliday junction ATP-dependent DNA helicase RuvA\tK03550 ruvA; holliday junction DNA helicase RuvA" }, { "name":"MSIM_03950 ruvB; Holliday junction ATP-dependent DNA helicase RuvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]" }, { "name":"MSIM_03970 ruvC; crossover junction endodeoxyribonuclease RuvC\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]" }, { "name":"MSIM_02780 priA_2; putative primosomal protein N'\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]" }, { "name":"MSIM_28830 radA; DNA repair protein RadA\tK04485 radA; DNA repair protein RadA\/Sms" }, { "name":"MSIM_25080 recF; DNA replication and repair protein RecF\tK03629 recF; DNA replication and repair protein RecF" }, { "name":"MSIM_08030 recG; ATP-dependent DNA helicase RecG\tK03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]" }, { "name":"MSIM_42830 recO; DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)" }, { "name":"MSIM_27290 recR; recombination protein RecR\tK06187 recR; recombination protein RecR" }, { "name":"MSIM_54060 recN; DNA repair protein RecN\tK03631 recN; DNA repair protein RecN (Recombination protein N)" }, { "name":"MSIM_41210 hypothetical protein\tK06915 herA; DNA double-strand break repair helicase HerA and related ATPase" }, { "name":"MSIM_34490 mku; non-homologous end joining protein Ku\tK10979 ku; DNA end-binding protein Ku" }, { "name":"MSIM_00630 ATP-dependent DNA ligase\tK01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]" }, { "name":"MSIM_34550 ligD; multifunctional non-homologous end joining protein LigD\tK01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]" }, { "name":"MSIM_25050 gyrA; DNA gyrase subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]" }, { "name":"MSIM_23760 gyrB_1; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]" }, { "name":"MSIM_25060 gyrB_2; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]" }, { "name":"MSIM_11260 DNA topoisomerase\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]" }, { "name":"MSIM_28260 topA; DNA topoisomerase 1\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]" }, { "name":"MSIM_08170 hypothetical protein\tK03530 hupB; DNA-binding protein HU-beta" }, { "name":"MSIM_43790 recQ; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]" }, { "name":"MSIM_01450 dinB1; DNA polymerase IV 1\tK02346 dinB; DNA polymerase IV [EC:2.7.7.7]" }, { "name":"MSIM_09330 dinB; DNA polymerase IV\tK02346 dinB; DNA polymerase IV [EC:2.7.7.7]" }, { "name":"MSIM_25510 dinP; DNA polymerase IV\tK02346 dinB; DNA polymerase IV [EC:2.7.7.7]" }, { "name":"MSIM_05180 lexA; LexA repressor\tK01356 lexA; repressor LexA [EC:3.4.21.88]" }, { "name":"MSIM_14510 hypothetical protein\tK14161 imuB; protein ImuB" }, { "name":"MSIM_14430 dnaE2; error-prone DNA polymerase\tK14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]" }, { "name":"MSIM_05290 recX; regulatory protein RecX\tK03565 recX; regulatory protein" }, { "name":"MSIM_39940 dinG; putative ATP-dependent helicase DinG\tK03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]" }, { "name":"MSIM_13710 lhr; ATP-dependent helicase\tK03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]" }, { "name":"MSIM_08160 mutT1; putative 8-oxo-dGTP diphosphatase 1\tK23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]" }, { "name":"MSIM_54020 NUDIX hydrolase\tK01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]" }, { "name":"MSIM_09280 nrdE; ribonucleoside-diphosphate reductase subunit alpha\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]" }, { "name":"MSIM_08910 nrdF; ribonucleoside-diphosphate reductase subunit beta\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]" }, { "name":"MSIM_20410 nrdB; R2-like ligand binding oxidase\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]" }, { "name":"MSIM_06300 phosphoesterase\tK06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]" } ] }, { "name":"03029 Mitochondrial biogenesis [BR:msim03029]", "children":[ { "name":"MSIM_06320 hypothetical protein\tK02519 infB; translation initiation factor IF-2" }, { "name":"MSIM_00370 infC; translation initiation factor IF-3\tK02520 infC; translation initiation factor IF-3" }, { "name":"MSIM_06950 tsf; elongation factor Ts\tK02357 tsf; elongation factor Ts" }, { "name":"MSIM_16170 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu" }, { "name":"MSIM_16180 fusA; elongation factor G\tK02355 fusA; elongation factor G" }, { "name":"MSIM_22180 elongation factor G-like protein\tK02355 fusA; elongation factor G" }, { "name":"MSIM_42770 era; GTPase Era\tK03595 era; GTPase" }, { "name":"MSIM_54140 tyrS; tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]" }, { "name":"MSIM_24480 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]" }, { "name":"MSIM_03470 aspS; aspartate--tRNA(Asp\/Asn) ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]" }, { "name":"MSIM_42880 glyQS; glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]" }, { "name":"MSIM_39590 argS; arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]" }, { "name":"MSIM_03070 amidase\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_08390 gatA_1; glutamyl-tRNA(Gln) amidotransferase subunit A\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_08360 gatB; aspartyl\/glutamyl-tRNA(Asn\/Gln) amidotransferase subunit B\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_08400 gatC; glutamyl-tRNA(Gln) amidotransferase subunit C\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]" }, { "name":"MSIM_24160 ssb; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_41500 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein" }, { "name":"MSIM_19180 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"MSIM_19170 grpE; protein GrpE\tK03687 GRPE; molecular chaperone GrpE" }, { "name":"MSIM_14830 groL1; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_18110 groL_1; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_49500 groL_2; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_14840 groS; 10 kDa chaperonin\tK04078 groES; chaperonin GroES" }, { "name":"MSIM_19160 dnaJ1; chaperone protein DnaJ 1\tK03686 dnaJ; molecular chaperone DnaJ" }, { "name":"MSIM_42700 dnaJ2; chaperone protein DnaJ 2\tK03686 dnaJ; molecular chaperone DnaJ" }, { "name":"MSIM_08500 iscS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]" }, { "name":"MSIM_38730 mrp; iron-sulfur cluster carrier protein\tK03593 mrp; ATP-binding protein involved in chromosome partitioning" }, { "name":"MSIM_02290 ctaB; protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]" }, { "name":"MSIM_02250 heme A synthase\tK02259 COX15; heme a synthase [EC:1.17.99.9]" }, { "name":"MSIM_25140 yidC; membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase" }, { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" } ] } ] }, { "name":"09183 Protein families: signaling and cellular processes", "children":[ { "name":"02000 Transporters [BR:msim02000]", "children":[ { "name":"MSIM_40140 irtA; iron import ATP-binding\/permease protein IrtA\tK14698 irtA; ATP-binding cassette, subfamily B, bacterial IrtA\/YbtP [EC:7.-.-.-]" }, { "name":"MSIM_40150 irtB; iron import ATP-binding\/permease protein IrtB\tK14699 irtB; ATP-binding cassette, subfamily B, bacterial IrtB\/YbtQ [EC:7.-.-.-]" }, { "name":"MSIM_39220 putative ABC transporter ATP-binding protein\tK18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump" }, { "name":"MSIM_39210 putative ABC transporter ATP-binding protein\tK24820 K24820; ATP-binding cassette, subfamily B, fatty acid transporter" }, { "name":"MSIM_00780 cydC; thiol reductant ABC exporter subunit CydC\tK16012 cydC; ATP-binding cassette, subfamily C, bacterial CydC" }, { "name":"MSIM_00770 cydD; thiol reductant ABC exporter subunit CydD\tK16013 cydD; ATP-binding cassette, subfamily C, bacterial CydD" }, { "name":"MSIM_51880 bacA; vitamin B12 transport ATP-binding protein BacA\tK02471 bacA; vitamin B12\/bleomycin\/antimicrobial peptide transport system ATP-binding\/permease protein" }, { "name":"MSIM_00100 hypothetical protein\tK15738 uup; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_54280 hypothetical protein\tK15738 uup; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_00590 ABC transporter ATP-binding\/permease protein\tK21397 K21397; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_10100 hypothetical protein\tK21397 K21397; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_14300 ABC transporter ATP-binding\/permease Rv1747\tK21397 K21397; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_14310 ABC transporter ATP-binding\/permease protein\tK21397 K21397; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_39140 ABC transporter ATP-binding protein\tK21397 K21397; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_52930 ABC transporter ATP-binding\/permease protein\tK21397 K21397; ABC transport system ATP-binding\/permease protein" }, { "name":"MSIM_42370 subI; sulfate ABC transporter substrate-binding protein\tK23163 sbp; sulfate\/thiosulfate transport system substrate-binding protein" }, { "name":"MSIM_42380 cysT; sulfate ABC transporter permease subunit CysT\tK02046 cysU; sulfate\/thiosulfate transport system permease protein" }, { "name":"MSIM_42390 cysW; sulfate ABC transporter permease CysW\tK02047 cysW; sulfate\/thiosulfate transport system permease protein" }, { "name":"MSIM_42400 cysA; sulfate\/thiosulfate import ATP-binding protein CysA\tK02045 cysA; sulfate\/thiosulfate transport system ATP-binding protein [EC:7.3.2.3]" }, { "name":"MSIM_51430 modA; molybdate-binding protein\tK02020 modA; molybdate transport system substrate-binding protein" }, { "name":"MSIM_51420 modB; molybdenum transport system permease protein ModB\tK02018 modB; molybdate transport system permease protein" }, { "name":"MSIM_51410 modC; molybdenum import ATP-binding protein ModC\tK02017 modC; molybdate transport system ATP-binding protein [EC:7.3.2.5]" }, { "name":"MSIM_03170 putative nitrate ABC transporter, periplasmic protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_23240 aliphatic sulfonate ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_23730 ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_32730 ABC transporter substrate-binding protein\tK15553 ssuA; sulfonate transport system substrate-binding protein" }, { "name":"MSIM_03160 putative nitrate ABC transporter, permease protein\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_23220 sulfate ABC transporter permease\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_23720 putative nitrate ABC transporter, permease protein\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_32750 ABC transporter permease\tK15554 ssuC; sulfonate transport system permease protein" }, { "name":"MSIM_03150 putative nitrate ABC transporter, ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_23230 ABC transporter ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_23710 ABC transporter ATP-binding protein\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_32740 ssuB; aliphatic sulfonates import ATP-binding protein SsuB\tK15555 ssuB; sulfonate transport system ATP-binding protein [EC:7.6.2.14]" }, { "name":"MSIM_26500 proX; glycine\/betaine ABC transporter substrate-binding protein\tK05845 opuC; osmoprotectant transport system substrate-binding protein" }, { "name":"MSIM_26520 proW; ABC transporter permease\tK05846 opuBD; osmoprotectant transport system permease protein" }, { "name":"MSIM_26530 proZ; ABC transporter permease\tK05846 opuBD; osmoprotectant transport system permease protein" }, { "name":"MSIM_26510 proV; proline\/glycine betaine ABC transporter ATP-binding protein\tK05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9]" }, { "name":"MSIM_41060 putative sulfonate ABC transporter, periplasmic protein\tK02051 ABC.SN.S; NitT\/TauT family transport system substrate-binding protein" }, { "name":"MSIM_41070 putative sulfonate ABC transporter, permease\tK02050 ABC.SN.P; NitT\/TauT family transport system permease protein" }, { "name":"MSIM_38820 sugC; trehalose import ATP-binding protein SugC\tK10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]" }, { "name":"MSIM_47980 sugar ABC transporter ATP-binding protein\tK10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]" }, { "name":"MSIM_38790 lpqY; hypothetical protein\tK10236 thuE; trehalose\/maltose transport system substrate-binding protein" }, { "name":"MSIM_38800 sugA; trehalose transport system permease protein SugA\tK10237 thuF; trehalose\/maltose transport system permease protein" }, { "name":"MSIM_38810 sugB; trehalose transport system permease protein SugB\tK10238 thuG; trehalose\/maltose transport system permease protein" }, { "name":"MSIM_21230 mce1F; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21240 lprK; lipoprotein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21250 mce1D; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21260 mce1C; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21270 mce1B; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21280 mce1A; cell invasion protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29740 mce4A; Mce family protein Mce4A\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29750 mce4B; Mce family protein Mce4B\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29760 mce4C; Mce family protein Mce4C\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29770 mce4D; mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29780 lprN; hypothetical protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_29790 mce4F; Mce family protein Mce4\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_30850 mce2A; Mce family protein Mce2A\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32330 virulence factor\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32340 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32350 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32360 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32370 virulence factor Mce\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_32380 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43050 mce3A; MCE-family protein MCE3A\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43060 mce3B; Mce family protein Mce3B\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43070 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43080 mce3D; Mce family protein Mce3D\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43090 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_43100 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_46970 putative Mce family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_46980 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_46990 putative MCE family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_47000 putative MCE family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_47010 putative MCE family protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_47020 mammalian cell entry protein\tK02067 mlaD; phospholipid\/cholesterol\/gamma-HCH transport system substrate-binding protein" }, { "name":"MSIM_21290 yrbE1B; ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_21300 yrbE1A; membrane protein\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_29720 yrbE4A; ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_29730 yrbE4B; ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_32310 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_32320 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_43030 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_43040 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_47030 ABC transporter permease\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_47040 ABC transporter\tK02066 mlaE; phospholipid\/cholesterol\/gamma-HCH transport system permease protein" }, { "name":"MSIM_16310 mkl; putative ribonucleotide transport ATP-binding protein mkl\tK02065 mlaF; phospholipid\/cholesterol\/gamma-HCH transport system ATP-binding protein" }, { "name":"MSIM_21190 Mce associated membrane protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_21200 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_21210 membrane protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_21220 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_29800 mammalian cell entry protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_29810 Mce associated protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_32230 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_32240 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_32400 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_32410 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_43110 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_43120 outer membrane protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_46960 hypothetical protein\tK18481 mas; Mce-associated membrane protein" }, { "name":"MSIM_43330 uspC; sugar ABC transporter substrate-binding lipoprotein UspC\tK02027 ABC.MS.S; multiple sugar transport system substrate-binding protein" }, { "name":"MSIM_47950 sugar ABC transporter substrate-binding lipoprotein\tK02027 ABC.MS.S; multiple sugar transport system substrate-binding protein" }, { "name":"MSIM_43350 uspA; sugar ABC transporter permease\tK02025 ABC.MS.P; multiple sugar transport system permease protein" }, { "name":"MSIM_47960 sugar ABC transporter permease\tK02025 ABC.MS.P; multiple sugar transport system permease protein" }, { "name":"MSIM_43340 uspB; sugar ABC transporter permease\tK02026 ABC.MS.P1; multiple sugar transport system permease protein" }, { "name":"MSIM_47970 ABC transporter permease\tK02026 ABC.MS.P1; multiple sugar transport system permease protein" }, { "name":"MSIM_15850 pstS3_1; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_31020 phoS3; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_34460 pstS3_2; phosphate-binding protein PstS 3\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_49030 pstS2; phosphate-binding protein PstS\tK02040 pstS; phosphate transport system substrate-binding protein" }, { "name":"MSIM_31030 pstC; phosphate transport system permease protein\tK02037 pstC; phosphate transport system permease protein" }, { "name":"MSIM_34470 pstC2; phosphate transport system permease protein PstC 2\tK02037 pstC; phosphate transport system permease protein" }, { "name":"MSIM_31040 pstA; phosphate transport system permease protein PstA\tK02038 pstA; phosphate transport system permease protein" }, { "name":"MSIM_34480 pstA1; phosphate transport system permease protein PstA 1\tK02038 pstA; phosphate transport system permease protein" }, { "name":"MSIM_31050 pstB; phosphate import ATP-binding protein PstB\tK02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]" }, { "name":"MSIM_24290 phnD; phosphate-import protein PhnD\tK02044 phnD; phosphonate transport system substrate-binding protein" }, { "name":"MSIM_24270 phnE; phosphate-import permease protein PhnE\tK02042 phnE; phosphonate transport system permease protein" }, { "name":"MSIM_24280 phnC; phosphate-import ATP-binding protein PhnC\tK02041 phnC; phosphonate transport system ATP-binding protein [EC:7.3.2.2]" }, { "name":"MSIM_37880 hypothetical protein\tK01999 livK; branched-chain amino acid transport system substrate-binding protein" }, { "name":"MSIM_18580 glnH; ABC transporter substrate-binding protein\tK02030 ABC.PA.S; polar amino acid transport system substrate-binding protein" }, { "name":"MSIM_24440 amino acid ABC transporter permease\tK02029 ABC.PA.P; polar amino acid transport system permease protein" }, { "name":"MSIM_24450 ABC transporter ATP-binding protein\tK02028 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1]" }, { "name":"MSIM_28090 dppA; peptide ABC transporter substrate-binding protein\tK15580 oppA; oligopeptide transport system substrate-binding protein" }, { "name":"MSIM_28100 dppB; peptide ABC transporter\tK15581 oppB; oligopeptide transport system permease protein" }, { "name":"MSIM_28110 dppC; peptide ABC transporter permease\tK15582 oppC; oligopeptide transport system permease protein" }, { "name":"MSIM_28120 dppD; peptide ABC transporter ATP-binding protein\tK10823 oppF; oligopeptide transport system ATP-binding protein" }, { "name":"MSIM_39300 hypothetical protein\tK13889 gsiB; glutathione transport system substrate-binding protein" }, { "name":"MSIM_39330 peptide ABC transporter permease\tK13890 gsiC; glutathione transport system permease protein" }, { "name":"MSIM_39320 putative peptide transport permease protein\tK13891 gsiD; glutathione transport system permease protein" }, { "name":"MSIM_39310 putative ABC transporter ATP-binding protein\tK13892 gsiA; glutathione transport system ATP-binding protein" }, { "name":"MSIM_03870 putative lipoprotein\tK02035 ABC.PE.S; peptide\/nickel transport system substrate-binding protein" }, { "name":"MSIM_08870 fecB; FeIII-dicitrate-binding periplasmic lipoprotein\tK02016 ABC.FEV.S; iron complex transport system substrate-binding protein" }, { "name":"MSIM_20020 iron ABC transporter substrate-binding protein\tK02016 ABC.FEV.S; iron complex transport system substrate-binding protein" }, { "name":"MSIM_08840 ABC transporter ATP-binding protein\tK02013 ABC.FEV.A; iron complex transport system ATP-binding protein [EC:7.2.2.-]" }, { "name":"MSIM_43260 hypothetical protein\tK16785 ecfT; energy-coupling factor transport system permease protein" }, { "name":"MSIM_43250 putative ABC transporter ATP-binding protein\tK01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]" }, { "name":"MSIM_48730 hypothetical protein\tK01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]" }, { "name":"MSIM_07900 ABC transporter substrate-binding protein\tK02077 ABC.ZM.S; zinc\/manganese transport system substrate-binding protein" }, { "name":"MSIM_29010 ABC transporter substrate-binding protein\tK02077 ABC.ZM.S; zinc\/manganese transport system substrate-binding protein" }, { "name":"MSIM_07870 ABC transporter permease\tK02075 ABC.ZM.P; zinc\/manganese transport system permease protein" }, { "name":"MSIM_07880 ABC transporter permease\tK02075 ABC.ZM.P; zinc\/manganese transport system permease protein" }, { "name":"MSIM_28990 helicase\tK02075 ABC.ZM.P; zinc\/manganese transport system permease protein" }, { "name":"MSIM_07890 ABC transporter ATP-binding protein\tK02074 ABC.ZM.A; zinc\/manganese transport system ATP-binding protein" }, { "name":"MSIM_29000 ABC transporter ATP-binding protein\tK02074 ABC.ZM.A; zinc\/manganese transport system ATP-binding protein" }, { "name":"MSIM_26180 sugar ABC transporter permease\tK09690 wzm; homopolymeric O-antigen transport system permease protein" }, { "name":"MSIM_26200 ABC transporter ATP-binding protein\tK09691 wzt; homopolymeric O-antigen transport system ATP-binding protein [EC:7.5.2.14]" }, { "name":"MSIM_38650 ABC transporter permease\tK25149 narB; polyether ionophore transport system permease protein" }, { "name":"MSIM_38660 tetronasin ABC transporter ATP-binding protein\tK25150 narA; polyether ionophore transport system ATP-binding protein" }, { "name":"MSIM_10710 ftsX; cell division protein FtsX\tK09811 ftsX; cell division transport system permease protein" }, { "name":"MSIM_10720 ftsE; cell division ATP-binding protein FtsE\tK09812 ftsE; cell division transport system ATP-binding protein" }, { "name":"MSIM_01610 drrB_1; doxorubicin resistance ABC transporter permease protein DrrB\tK01992 ABC-2.P; ABC-2 type transport system permease protein" }, { "name":"MSIM_01620 drrC; putative doxorubicin resistance ABC transporter permease protein DrrC\tK01992 ABC-2.P; ABC-2 type transport system permease protein" }, { "name":"MSIM_02240 multidrug ABC transporter permease\tK01992 ABC-2.P; ABC-2 type transport system permease protein" }, { "name":"MSIM_07790 drrB_2; doxorubicin resistance ABC transporter permease DrrB\tK01992 ABC-2.P; ABC-2 type transport system permease protein" }, { "name":"MSIM_07800 peptide ABC transporter permease\tK01992 ABC-2.P; ABC-2 type transport system permease protein" }, { "name":"MSIM_22110 transport permease protein\tK01992 ABC-2.P; ABC-2 type transport system permease protein" }, { "name":"MSIM_54180 transport permease protein\tK01992 ABC-2.P; ABC-2 type transport system permease protein" }, { "name":"MSIM_01600 daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein\tK01990 ABC-2.A; ABC-2 type transport system ATP-binding protein" }, { "name":"MSIM_02230 spermidine\/putrescine ABC transporter ATP-binding protein\tK01990 ABC-2.A; ABC-2 type transport system ATP-binding protein" }, { "name":"MSIM_07780 daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein\tK01990 ABC-2.A; ABC-2 type transport system ATP-binding protein" }, { "name":"MSIM_22100 ABC transporter ATP-binding protein\tK01990 ABC-2.A; ABC-2 type transport system ATP-binding protein" }, { "name":"MSIM_54170 multidrug ABC transporter ATP-binding protein\tK01990 ABC-2.A; ABC-2 type transport system ATP-binding protein" }, { "name":"MSIM_52550 permease\tK02004 ABC.CD.P; putative ABC transport system permease protein" }, { "name":"MSIM_52540 ABC transporter ATP-binding protein\tK02003 ABC.CD.A; putative ABC transport system ATP-binding protein" }, { "name":"MSIM_02180 sufC; ABC transporter ATP-binding protein\tK09013 sufC; Fe-S cluster assembly ATP-binding protein" }, { "name":"MSIM_24510 putative Na+-dependent transporter\tK14347 SLC10A7; solute carrier family 10 (sodium\/bile acid cotransporter), member 7" }, { "name":"MSIM_45130 proP; proline\/betaine transporter\tK03762 proP; MFS transporter, MHS family, proline\/betaine transporter" }, { "name":"MSIM_48390 oxalate\/formate MFS antiporter\tK08177 oxlT; MFS transporter, OFA family, oxalate\/formate antiporter" }, { "name":"MSIM_50680 nanT; MFS transporter\tK08178 JEN; MFS transporter, SHS family, lactate transporter" }, { "name":"MSIM_10280 MFS transporter\tK08176 PHO84; MFS transporter, PHS family, inorganic phosphate transporter" }, { "name":"MSIM_23140 hypothetical protein\tK08176 PHO84; MFS transporter, PHS family, inorganic phosphate transporter" }, { "name":"MSIM_20060 narK3_1; MFS transporter\tK02575 NRT2; MFS transporter, NNP family, nitrate\/nitrite transporter" }, { "name":"MSIM_20070 narK3_2; MFS transporter\tK02575 NRT2; MFS transporter, NNP family, nitrate\/nitrite transporter" }, { "name":"MSIM_20940 narK3_3; MFS transporter\tK02575 NRT2; MFS transporter, NNP family, nitrate\/nitrite transporter" }, { "name":"MSIM_30520 emrB_2; multidrug resistance protein B\tK03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein" }, { "name":"MSIM_30530 emrB_3; multidrug resistance protein B\tK03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein" }, { "name":"MSIM_02600 putative triacylglyceride transporter\tK27247 K27247; MFS transporter, DHA2 family, triacylglyceride efflux pump" }, { "name":"MSIM_39850 putative transporter\tK08224 ynfM; MFS transporter, YNFM family, putative membrane transport protein" }, { "name":"MSIM_41230 MFS transporter\tK06902 UMF1; MFS transporter, UMF1 family" }, { "name":"MSIM_07050 ydjE; MFS transporter\tK08369 ydjE; MFS transporter, putative metabolite:H+ symporter" }, { "name":"MSIM_12100 NAD-binding protein of Kef-type K+ transporter\tK10716 kch; voltage-gated potassium channel" }, { "name":"MSIM_07460 amt_1; ammonium transporter\tK03320 amt; ammonium transporter, Amt family" }, { "name":"MSIM_07580 amt_2; putative ammonia channel\tK03320 amt; ammonium transporter, Amt family" }, { "name":"MSIM_54160 ammonium transporter\tK03320 amt; ammonium transporter, Amt family" }, { "name":"MSIM_02010 UPF0353 protein\tK07114 yfbK; Ca-activated chloride channel homolog" }, { "name":"MSIM_13900 UPF0353 protein\tK07114 yfbK; Ca-activated chloride channel homolog" }, { "name":"MSIM_13910 UPF0353 protein\tK07114 yfbK; Ca-activated chloride channel homolog" }, { "name":"MSIM_34960 mscL; large-conductance mechanosensitive channel\tK03282 mscL; large conductance mechanosensitive channel" }, { "name":"MSIM_10740 hypothetical protein\tK22044 ybiO; moderate conductance mechanosensitive channel" }, { "name":"MSIM_38840 corA; magnesium transport protein CorA\tK03284 corA; magnesium transporter" }, { "name":"MSIM_09920 crcB1; putative fluoride ion transporter CrcB 1\tK06199 crcB; fluoride exporter" }, { "name":"MSIM_09930 crcB2; putative fluoride ion transporter CrcB 2\tK06199 crcB; fluoride exporter" }, { "name":"MSIM_30680 DUF1211 domain-containing membrane protein\tK24915 TMEM175; TMEM175 potassium channel family protein" }, { "name":"MSIM_42750 UPF0053 protein\tK03699 tlyC; magnesium and cobalt exporter, CNNM family" }, { "name":"MSIM_51700 UPF0053 protein\tK03699 tlyC; magnesium and cobalt exporter, CNNM family" }, { "name":"MSIM_51710 membrane protein\tK03699 tlyC; magnesium and cobalt exporter, CNNM family" }, { "name":"MSIM_17270 gabP; gaba permease gabP (4-amino butyrate transport carrier)\tK11735 gabP; GABA permease" }, { "name":"MSIM_50130 cycA; amino acid transporter\tK11737 cycA; D-serine\/D-alanine\/glycine transporter" }, { "name":"MSIM_46890 ansP1; L-asparagine permease 1\tK11738 ansP; L-asparagine permease" }, { "name":"MSIM_51500 amino acid permease\tK28029 UGA4; amino acid or GABA permease" }, { "name":"MSIM_18850 cation transporter\tK16264 czcD; cobalt-zinc-cadmium efflux system protein" }, { "name":"MSIM_20790 mmpL3; putative trehalose monomycolate exporter MmpL3\tK20470 mmpL3; trehalose monomycolate\/heme transporter" }, { "name":"MSIM_20830 mmpL11; putative transport protein MmpL11\tK20466 mmpL11; heme transporter" }, { "name":"MSIM_09640 mmr; multidrug resistance protein Mmr\tK03297 emrE; small multidrug resistance pump" }, { "name":"MSIM_00670 membrane protein\tK09936 TC.BAT2; bacterial\/archaeal transporter family-2 protein" }, { "name":"MSIM_18650 UPF0060 membrane protein\tK09771 TC.SMR3; small multidrug resistance family-3 protein" }, { "name":"MSIM_49830 L-lactate permease\tK03303 lutP; lactate permease" }, { "name":"MSIM_00930 ionic transporter y4hA\tK07300 chaA; Ca2+:H+ antiporter" }, { "name":"MSIM_22730 sodium\/calcium exchanger family protein\tK07301 yrbG; cation:H+ antiporter" }, { "name":"MSIM_20960 cation acetate symporter\tK14393 actP; cation\/acetate symporter" }, { "name":"MSIM_44670 putative Na(+)\/H(+) exchanger\tK24163 nhaK; monovalent cation\/hydrogen antiporter" }, { "name":"MSIM_04850 cvrA; sodium\/hydrogen exchanger\tK11105 cvrA; potassium\/hydrogen antiporter" }, { "name":"MSIM_33300 putative Na(+)\/H(+) antiporter\tK11105 cvrA; potassium\/hydrogen antiporter" }, { "name":"MSIM_20910 hypothetical protein\tK26731 CHX; K+:H+ antiporter" }, { "name":"MSIM_04880 ceoB; potassium transporter TrkA\tK03499 trkA; trk\/ktr system potassium uptake protein" }, { "name":"MSIM_04890 ceoC; potassium transporter TrkA\tK03499 trkA; trk\/ktr system potassium uptake protein" }, { "name":"MSIM_33290 putative potassium uptake protein\tK03499 trkA; trk\/ktr system potassium uptake protein" }, { "name":"MSIM_36580 allantoin permease\tK23467 tgnP; trigonelline permease" }, { "name":"MSIM_03610 hypothetical protein\tK06901 pbuG; adenine\/guanine\/hypoxanthine permease" }, { "name":"MSIM_20270 chloride channel protein\tK03281 clcA; chloride channel protein, CIC family" }, { "name":"MSIM_21800 hypothetical protein\tK03281 clcA; chloride channel protein, CIC family" }, { "name":"MSIM_31240 chrA; chromate resistance transporter\tK07240 chrA; chromate transporter" }, { "name":"MSIM_06490 nicT; nickel\/cobalt efflux system\tK07241 hoxN; nickel\/cobalt transporter (NiCoT) family protein" }, { "name":"MSIM_23690 sodium-independent anion transporter\tK03321 TC.SULP; sulfate permease, SulP family" }, { "name":"MSIM_34430 hypothetical protein\tK03322 mntH; manganese transport protein" }, { "name":"MSIM_46020 hypothetical protein\tK01551 arsA; arsenite\/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]" }, { "name":"MSIM_28940 arsB2; arsenic transport integral membrane protein ArsB\tK03893 arsB; arsenical pump membrane protein" }, { "name":"MSIM_49370 putative arsenic-transport integral membrane protein ArsC\tK03325 ACR3; arsenite transporter" }, { "name":"MSIM_25260 mviN; putative peptidoglycan biosynthesis protein MviN\tK03980 murJ; putative peptidoglycan lipid II flippase" }, { "name":"MSIM_20800 AI-2E family transporter\tK20469 K20469; putative heme transporter" }, { "name":"MSIM_43210 membrane protein\tK22736 VIT; vacuolar iron transporter family protein" }, { "name":"MSIM_24920 rodA; putative FtsW-like protein\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_46310 ftsW; cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]" }, { "name":"MSIM_25600 UPF0016 family membrane protein\tK23541 TMEM165; Ca2+\/H+ antiporter, TMEM165\/GDT1 family" }, { "name":"MSIM_48020 hypothetical protein\tK07243 FTR; high-affinity iron transporter" }, { "name":"MSIM_48040 lipoprotein\tK07224 efeO; iron uptake system component EfeO" }, { "name":"MSIM_48050 hypothetical protein\tK16301 efeB; deferrochelatase\/peroxidase EfeB [EC:1.11.1.-]" }, { "name":"MSIM_09450 carbon starvation protein A\tK06200 cstA; carbon starvation protein" }, { "name":"MSIM_46680 malonate decarboxylase subunit alpha\tK13929 mdcA; malonate decarboxylase alpha subunit [EC:2.3.1.187]" }, { "name":"MSIM_46700 mdcC; malonate decarboxylase acyl carrier protein\tK13931 mdcC; malonate decarboxylase delta subunit" }, { "name":"MSIM_17220 ccdA; cytochrome C biogenesis protein CcdA\tK06196 ccdA; cytochrome c-type biogenesis protein" }, { "name":"MSIM_36210 hypothetical protein\tK25588 K25588; tyrosine-protein kinase [EC:2.7.10.3]" }, { "name":"MSIM_13170 hypothetical protein\tK27044 pacL1; chaperone-like protein" }, { "name":"MSIM_20810 hypothetical protein\tK20468 K20468; putative heme transporter" }, { "name":"MSIM_07650 hypothetical protein\tK04758 feoA; ferrous iron transport protein A" }, { "name":"MSIM_07640 ferrous iron transport protein B\tK04759 feoB; ferrous iron transport protein B" }, { "name":"MSIM_08710 tryptophan-rich sensory protein\tK05770 TSPO; translocator protein" }, { "name":"MSIM_00540 putative magnesium transport MgtC family protein\tK07507 mgtC; putative Mg2+ transporter-C (MgtC) family protein" }, { "name":"MSIM_51960 mgtC; methyltransferase\tK07507 mgtC; putative Mg2+ transporter-C (MgtC) family protein" }, { "name":"MSIM_09120 hypothetical protein\tK00389 yidH; inner membrane protein YidH" }, { "name":"MSIM_23740 hypothetical protein\tK00389 yidH; inner membrane protein YidH" }, { "name":"MSIM_25560 copper resistance protein C\tK07156 copC; copper resistance protein C" } ] }, { "name":"02044 Secretion system [BR:msim02044]", "children":[ { "name":"MSIM_28160 conjugal transfer protein\tK02283 cpaF; pilus assembly protein CpaF [EC:7.4.2.8]" }, { "name":"MSIM_28170 hypothetical protein\tK12510 tadB; tight adherence protein B" }, { "name":"MSIM_28180 hypothetical protein\tK12511 tadC; tight adherence protein C" }, { "name":"MSIM_46390 hypothetical protein\tK02221 yggT; YggT family protein" }, { "name":"MSIM_42200 membrane protein\tK02237 comEA; competence protein ComEA" }, { "name":"MSIM_42210 hypothetical protein\tK02238 comEC; competence protein ComEC" }, { "name":"MSIM_13220 hypothetical protein\tK27084 eccA; ESX secretion system protein EccA" }, { "name":"MSIM_19880 type VII secretion AAA-ATPase EccA\tK27084 eccA; ESX secretion system protein EccA" }, { "name":"MSIM_25390 eccA2; ESX-2 secretion system protein EccA2\tK27084 eccA; ESX secretion system protein EccA" }, { "name":"MSIM_52050 eccA5; ESX-5 secretion system protein EccA5\tK27084 eccA; ESX secretion system protein EccA" }, { "name":"MSIM_13260 hypothetical protein\tK27085 eccB; ESX secretion system ATPase EccB" }, { "name":"MSIM_15150 eccB4; ESX-4 secretion system ATPase EccB4\tK27085 eccB; ESX secretion system ATPase EccB" }, { "name":"MSIM_19870 ESX-3 secretion system protein eccB3\tK27085 eccB; ESX secretion system ATPase EccB" }, { "name":"MSIM_24580 eccB2; ESX-2 secretion system ATPase EccB2\tK27085 eccB; ESX secretion system ATPase EccB" }, { "name":"MSIM_52210 eccB5; ESX-5 secretion system ATPase EccB5\tK27085 eccB; ESX secretion system ATPase EccB" }, { "name":"MSIM_13280 putative FtsK\/SpoIIIE family protein\tK27086 eccC; ESX secretion system protein EccC" }, { "name":"MSIM_15120 eccC4; ESX-4 secretion system protein EccC4\tK27086 eccC; ESX secretion system protein EccC" }, { "name":"MSIM_19860 type VII secretion protein EccC\tK27086 eccC; ESX secretion system protein EccC" }, { "name":"MSIM_52200 eccC5; ESX-5 secretion system protein EccC5\tK27086 eccC; ESX secretion system protein EccC" }, { "name":"MSIM_13270 hypothetical protein\tK27087 eccD; ESX secretion system protein EccD" }, { "name":"MSIM_13290 hypothetical protein\tK27087 eccD; ESX secretion system protein EccD" }, { "name":"MSIM_15130 eccD4; ESX-4 secretion system protein eccD4\tK27087 eccD; ESX secretion system protein EccD" }, { "name":"MSIM_19800 eccD3; ESX-3 secretion system protein EccD3\tK27087 eccD; ESX secretion system protein EccD" }, { "name":"MSIM_25360 eccD2; ESX-2 secretion system protein eccD2\tK27087 eccD; ESX secretion system protein EccD" }, { "name":"MSIM_52080 eccD5; ESX-5 secretion system protein EccD5\tK27087 eccD; ESX secretion system protein EccD" }, { "name":"MSIM_13250 hypothetical protein\tK27088 eccE; ESX secretion system protein EccE" }, { "name":"MSIM_19780 type VII secretion protein EccE\tK27088 eccE; ESX secretion system protein EccE" }, { "name":"MSIM_25380 eccE2; ESX-2 secretion system protein EccE2\tK27088 eccE; ESX secretion system protein EccE" }, { "name":"MSIM_52060 type VII secretion protein EccE\tK27088 eccE; ESX secretion system protein EccE" }, { "name":"MSIM_13300 putative protease\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_15140 mycP4; mycosin-4\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_19790 type VII secretion-associated serine protease\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_25370 membrane-anchored mycosin\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_52070 hypothetical protein\tK14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]" }, { "name":"MSIM_13410 hypothetical protein\tK27091 espG; ESX secretion-associated protein EspG" }, { "name":"MSIM_19810 espG3; ESX-3 secretion-associated protein EspG3\tK27091 espG; ESX secretion-associated protein EspG" }, { "name":"MSIM_25340 espG2; ESX-2 secretion-associated protein EspG2\tK27091 espG; ESX secretion-associated protein EspG" }, { "name":"MSIM_52090 espG5; ESX-5 secretion-associated protein EspG5\tK27091 espG; ESX secretion-associated protein EspG" }, { "name":"MSIM_15090 esxT; ESAT-6-like protein EsxT\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_15100 esxU; ESAT-6-like protein EsxU\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_17430 esxF; ESAT-6-like protein EsxF\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_17440 esxE; secretion protein\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_19820 esxH; ESAT-6-like protein EsxH\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_19830 esxG; type VII secretion system protein EsxS\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_25320 hypothetical protein\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_25330 hypothetical protein\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_36870 esxN_1; ESAT-6-like protein EsxN\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_36880 esxP_1; ESAT-6-like protein EsxP\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_49620 esxN_2; ESAT-6-like protein EsxN\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_52100 esxN_3; ESAT-6-like protein EsxN\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_52110 esxP_2; ESAT-6-like protein EsxP\tK14956 esx; ESAT-6 family protein" }, { "name":"MSIM_12820 secA1; protein translocase subunit SecA 1\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_51860 secA2; protein translocase subunit SecA 2\tK03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]" }, { "name":"MSIM_03890 hypothetical protein\tK03072 secD; preprotein translocase subunit SecD" }, { "name":"MSIM_16520 secE; protein translocase subunit SecE\tK03073 secE; preprotein translocase subunit SecE" }, { "name":"MSIM_03880 secF; protein translocase subunit SecF\tK03074 secF; preprotein translocase subunit SecF" }, { "name":"MSIM_02380 secG; putative protein-export membrane protein SecG\tK03075 secG; preprotein translocase subunit SecG" }, { "name":"MSIM_15550 secY; protein translocase subunit SecY\tK03076 secY; preprotein translocase subunit SecY" }, { "name":"MSIM_07530 ffh; signal recognition particle protein\tK03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]" }, { "name":"MSIM_07590 ftsY; signal recognition particle receptor FtsY\tK03110 ftsY; fused signal recognition particle receptor" }, { "name":"MSIM_03900 hypothetical protein\tK03210 yajC; preprotein translocase subunit YajC" }, { "name":"MSIM_25140 yidC; membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase" }, { "name":"MSIM_47250 tatA; Sec-independent protein translocase protein TatA\tK03116 tatA; sec-independent protein translocase protein TatA" }, { "name":"MSIM_38720 tatB; sec-independent protein translocase protein TatB\tK03117 tatB; sec-independent protein translocase protein TatB" }, { "name":"MSIM_47260 tatC; Sec-independent protein translocase protein TatC\tK03118 tatC; sec-independent protein translocase protein TatC" } ] }, { "name":"02042 Bacterial toxins [BR:msim02042]", "children":[ { "name":"MSIM_42750 UPF0053 protein\tK03699 tlyC; magnesium and cobalt exporter, CNNM family" }, { "name":"MSIM_51700 UPF0053 protein\tK03699 tlyC; magnesium and cobalt exporter, CNNM family" }, { "name":"MSIM_51710 membrane protein\tK03699 tlyC; magnesium and cobalt exporter, CNNM family" }, { "name":"MSIM_32180 UPF0073 membrane protein\tK11068 hlyIII; hemolysin III" }, { "name":"MSIM_37200 UPF0073 membrane protein\tK11068 hlyIII; hemolysin III" } ] }, { "name":"02022 Two-component system [BR:msim02022]", "children":[ { "name":"MSIM_17640 senX3; sensor-like histidine kinase senX3\tK07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3]" }, { "name":"MSIM_17630 regX3; sensory transduction protein regX3\tK07776 regX3; two-component system, OmpR family, response regulator RegX3" }, { "name":"MSIM_36810 kdpD; sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]" }, { "name":"MSIM_36800 kdpE; DNA-binding response regulator\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE" }, { "name":"MSIM_34930 mprB; signal transduction histidine-protein kinase\/phosphatase MprB\tK07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]" }, { "name":"MSIM_34920 mprA; response regulator MprA\tK07669 mprA; two-component system, OmpR family, response regulator MprA" }, { "name":"MSIM_12910 mtrB; sensor histidine kinase MtrB\tK07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]" }, { "name":"MSIM_12920 mtrA; DNA-binding response regulator MtrA\tK07670 mtrA; two-component system, OmpR family, response regulator MtrA" }, { "name":"MSIM_23280 two-component sensor histidine kinase\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]" }, { "name":"MSIM_33110 prrB; sensor-type histidine kinase PrrB\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]" }, { "name":"MSIM_33120 prrA_2; transcriptional regulatory protein PrrA\tK07671 prrA; two-component system, OmpR family, response regulator PrrA" }, { "name":"MSIM_36850 trcS; two-component sensor histidine kinase\tK07656 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3]" }, { "name":"MSIM_36860 trcR; DNA-binding response regulator\tK07672 trcR; two-component system, OmpR family, response regulator TrcR" }, { "name":"MSIM_26380 two-component sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]" }, { "name":"MSIM_30140 two-component sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]" }, { "name":"MSIM_26370 tcrX; putative transcriptional regulatory protein TcrX\tK02483 K02483; two-component system, OmpR family, response regulator" }, { "name":"MSIM_30130 phoP; DNA-binding response regulator\tK02483 K02483; two-component system, OmpR family, response regulator" }, { "name":"MSIM_31470 narL; putative transcriptional regulatory protein NarL\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL" }, { "name":"MSIM_48260 diguanylate cyclase\tK07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]" }, { "name":"MSIM_48250 devR; transcriptional regulatory protein DevR (DosR)\tK07695 devR; two-component system, NarL family, response regulator DevR" }, { "name":"MSIM_31480 histidine kinase\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]" }, { "name":"MSIM_11300 hypothetical protein\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_11330 cheB; chemotaxis protein CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_12330 ATPase\tK00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]" }, { "name":"MSIM_00710 transcriptional regulator\tK22010 pdtaR; two-component system, response regulator PdtaR" } ] }, { "name":"02035 Bacterial motility proteins [BR:msim02035]", "children":[ { "name":"MSIM_11310 cheR; chemotaxis protein CheR\tK00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80]" }, { "name":"MSIM_11300 hypothetical protein\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_11330 cheB; chemotaxis protein CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]" }, { "name":"MSIM_28160 conjugal transfer protein\tK02283 cpaF; pilus assembly protein CpaF [EC:7.4.2.8]" } ] }, { "name":"03037 Cilium and associated proteins [BR:msim03037]", "children":[ { "name":"MSIM_54000 methyltransferase\tK00545 COMT; catechol O-methyltransferase [EC:2.1.1.6]" } ] }, { "name":"04812 Cytoskeleton proteins [BR:msim04812]", "children":[ { "name":"MSIM_46350 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ" }, { "name":"MSIM_12260 chromosome partitioning protein ParA\tK03496 parA; chromosome partitioning protein" }, { "name":"MSIM_25170 parA; chromosome partitioning protein ParA\tK03496 parA; chromosome partitioning protein" }, { "name":"MSIM_53990 hypothetical protein\tK03496 parA; chromosome partitioning protein" }, { "name":"MSIM_25180 parB; putative chromosome-partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein" } ] }, { "name":"04147 Exosome [BR:msim04147]", "children":[ { "name":"MSIM_44240 htpG; chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG" }, { "name":"MSIM_23370 class I fructose-bisphosphate aldolase\tK01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]" }, { "name":"MSIM_36760 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"MSIM_02410 gap; glyceraldehyde-3-phosphate dehydrogenase\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]" }, { "name":"MSIM_02400 pgk; phosphoglycerate kinase\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]" }, { "name":"MSIM_00810 pykA; pyruvate kinase\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_06140 hypothetical protein\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"MSIM_25000 ppiA; peptidyl-prolyl cis-trans isomerase A\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]" }, { "name":"MSIM_26160 flotillin family protein\tK07192 FLOT; flotillin" }, { "name":"MSIM_14830 groL1; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_18110 groL_1; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_49500 groL_2; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" }, { "name":"MSIM_19180 dnaK; chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"MSIM_34670 pgi; glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]" }, { "name":"MSIM_34020 hypothetical protein\tK01053 gnl; gluconolactonase [EC:3.1.1.17]" }, { "name":"MSIM_14620 guaB3; putative oxidoreductase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]" }, { "name":"MSIM_14630 guaB; inosine-5'-monophosphate dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]" }, { "name":"MSIM_16170 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu" }, { "name":"MSIM_39070 hydrolase\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]" }, { "name":"MSIM_24510 putative Na+-dependent transporter\tK14347 SLC10A7; solute carrier family 10 (sodium\/bile acid cotransporter), member 7" }, { "name":"MSIM_35640 hypothetical protein\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_43580 AMP-dependent ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_45990 long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]" }, { "name":"MSIM_09550 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_20240 fadA2; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_29540 ltp3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_32640 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_33260 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_34750 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_37090 fadA3; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_39890 fadA4; putative acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40210 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_40460 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_44400 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_51280 acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]" }, { "name":"MSIM_12940 ahcY; adenosylhomocysteinase\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]" }, { "name":"MSIM_15540 adk; adenylate kinase\tK00939 adk; adenylate kinase [EC:2.7.4.3]" }, { "name":"MSIM_03860 apt; adenine phosphoribosyltransferase\tK00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]" }, { "name":"MSIM_00210 argH; argininosuccinate lyase\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]" }, { "name":"MSIM_00220 argG; argininosuccinate synthase\tK01940 argG; argininosuccinate synthase [EC:6.3.4.5]" }, { "name":"MSIM_16670 galK; galactokinase\tK00849 galK; galactokinase [EC:2.7.1.6]" }, { "name":"MSIM_39910 glgB; 1,4-alpha-glucan branching enzyme GlgB\tK00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]" }, { "name":"MSIM_27520 glpK; glycerol kinase\tK00864 glpK; glycerol kinase [EC:2.7.1.30]" }, { "name":"MSIM_28420 glnT; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45490 glnA2; putative glutamine synthetase 2\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_45600 glnA1; glutamine synthetase 1\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51050 glnA3; glutamine synthetase GlnA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_51550 type III glutamate--ammonia ligase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_53180 glnN; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]" }, { "name":"MSIM_17380 hemB; delta-aminolevulinic acid dehydratase\tK01698 hemB; porphobilinogen synthase [EC:4.2.1.24]" }, { "name":"MSIM_38180 putative pterin-4-alpha-carbinolamine dehydratase\tK01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]" }, { "name":"MSIM_08260 serA; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_15610 serA2; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_35770 D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]" }, { "name":"MSIM_34800 purH; bifunctional purine biosynthesis protein PurH\tK00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase \/ IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]" }, { "name":"MSIM_54000 methyltransferase\tK00545 COMT; catechol O-methyltransferase [EC:2.1.1.6]" }, { "name":"MSIM_17890 lpdC; dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]" }, { "name":"MSIM_08530 etfA; electron transfer flavoprotein subunit alpha\tK03522 fixB; electron transfer flavoprotein alpha subunit" }, { "name":"MSIM_02320 zwf2; glucose-6-phosphate 1-dehydrogenase 2\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_37580 zwf1; glucose-6-phosphate 1-dehydrogenase 1\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_49840 zwf; glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]" }, { "name":"MSIM_02390 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]" }, { "name":"MSIM_17650 gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]" } ] }, { "name":"02048 Prokaryotic defense system [BR:msim02048]", "children":[ { "name":"MSIM_05480 hsdM; type I restriction endonuclease subunit M\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]" }, { "name":"MSIM_10200 hypothetical protein\tK07448 mrr; restriction system protein" }, { "name":"MSIM_53170 hypothetical protein\tK07448 mrr; restriction system protein" }, { "name":"MSIM_48850 hypothetical protein\tK28297 relB_F; antitoxin RelB\/F" }, { "name":"MSIM_46350 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ" }, { "name":"MSIM_08220 gltX; glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]" }, { "name":"MSIM_08500 iscS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]" } ] }, { "name":"04030 G protein-coupled receptors" }, { "name":"04050 Cytokine receptors" }, { "name":"04054 Pattern recognition receptors" }, { "name":"03310 Nuclear receptors" }, { "name":"04040 Ion channels" }, { "name":"04031 GTP-binding proteins" }, { "name":"04052 Cytokines and neuropeptides" }, { "name":"04515 Cell adhesion molecules" }, { "name":"04090 CD molecules" }, { "name":"01504 Antimicrobial resistance genes [BR:msim01504]", "children":[ { "name":"MSIM_20050 aac; aminoglycoside 2'-N-acetyltransferase\tK17840 aac2-I; aminoglycoside 2'-N-acetyltransferase I [EC:2.3.1.59]" }, { "name":"MSIM_51670 blaR; hypothetical protein\tK02172 blaR1; bla regulator protein blaR1" }, { "name":"MSIM_51660 blaI; transcriptional regulator BlaI\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor" }, { "name":"MSIM_05860 beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]" }, { "name":"MSIM_31300 lpqR; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]" } ] }, { "name":"00535 Proteoglycans" }, { "name":"00536 Glycosaminoglycan binding proteins" }, { "name":"00537 Glycosylphosphatidylinositol (GPI)-anchored proteins" }, { "name":"04091 Lectins" }, { "name":"04990 Domain-containing proteins not elsewhere classified" } ] }, { "name":"09185 Viral protein families", "children":[ { "name":"03200 Viral proteins" }, { "name":"03210 Viral fusion proteins" } ] }, { "name":"09184 RNA family", "children":[ { "name":"03100 Non-coding RNAs [BR:msim03100]", "children":[ { "name":"MSIM_t00090 tRNA-Ala\tK14218 tRNA-Ala; tRNA Ala" }, { "name":"MSIM_t00200 tRNA-Ala\tK14218 tRNA-Ala; tRNA Ala" }, { "name":"MSIM_t00350 tRNA-Ala\tK14218 tRNA-Ala; tRNA Ala" }, { "name":"MSIM_t00240 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00340 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00390 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00430 tRNA-Arg\tK14219 tRNA-Arg; tRNA Arg" }, { "name":"MSIM_t00470 tRNA-Asn\tK14220 tRNA-Asn; tRNA Asn" }, { "name":"MSIM_t00320 tRNA-Asp\tK14221 tRNA-Asp; tRNA Asp" }, { "name":"MSIM_t00040 tRNA-Cys\tK14222 tRNA-Cys; tRNA Cys" }, { "name":"MSIM_t00490 tRNA-Cys\tK14222 tRNA-Cys; tRNA Cys" }, { "name":"MSIM_t00070 tRNA-Gln\tK14223 tRNA-Gln; tRNA Gln" }, { "name":"MSIM_t00360 tRNA-Gln\tK14223 tRNA-Gln; tRNA Gln" }, { "name":"MSIM_t00060 tRNA-Glu\tK14224 tRNA-Glu; tRNA Glu" }, { "name":"MSIM_t00310 tRNA-Glu\tK14224 tRNA-Glu; tRNA Glu" }, { "name":"MSIM_t00030 tRNA-Gly\tK14225 tRNA-Gly; tRNA Gly" }, { "name":"MSIM_t00170 tRNA-Gly\tK14225 tRNA-Gly; tRNA Gly" }, { "name":"MSIM_t00450 tRNA-Gly\tK14225 tRNA-Gly; tRNA Gly" }, { "name":"MSIM_t00420 tRNA-His\tK14226 tRNA-His; tRNA His" }, { "name":"MSIM_t00210 tRNA-Ile\tK14227 tRNA-Ile; tRNA Ile" }, { "name":"MSIM_t00010 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00190 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00370 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00400 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00510 tRNA-Leu\tK14228 tRNA-Leu; tRNA Leu" }, { "name":"MSIM_t00300 tRNA-Lys\tK14229 tRNA-Lys; tRNA Lys" }, { "name":"MSIM_t00410 tRNA-Lys\tK14229 tRNA-Lys; tRNA Lys" }, { "name":"MSIM_t00100 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00130 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00480 tRNA-Met\tK14230 tRNA-Met; tRNA Met" }, { "name":"MSIM_t00330 tRNA-Phe\tK14231 tRNA-Phe; tRNA Phe" }, { "name":"MSIM_t00270 tRNA-Pro\tK14232 tRNA-Pro; tRNA Pro" }, { "name":"MSIM_t00460 tRNA-Pro\tK14232 tRNA-Pro; tRNA Pro" }, { "name":"MSIM_t00520 tRNA-Pro\tK14232 tRNA-Pro; tRNA Pro" }, { "name":"MSIM_t00220 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00230 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00250 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00260 tRNA-Ser\tK14233 tRNA-Ser; tRNA Ser" }, { "name":"MSIM_t00140 tRNA-Thr\tK14234 tRNA-Thr; tRNA Thr" }, { "name":"MSIM_t00280 tRNA-Thr\tK14234 tRNA-Thr; tRNA Thr" }, { "name":"MSIM_t00290 tRNA-Thr\tK14234 tRNA-Thr; tRNA Thr" }, { "name":"MSIM_t00120 tRNA-Trp\tK14235 tRNA-Trp; tRNA Trp" }, { "name":"MSIM_t00150 tRNA-Tyr\tK14236 tRNA-Tyr; tRNA Tyr" }, { "name":"MSIM_t00020 tRNA-Val\tK14237 tRNA-Val; tRNA Val" }, { "name":"MSIM_t00050 tRNA-Val\tK14237 tRNA-Val; tRNA Val" }, { "name":"MSIM_t00500 tRNA-Val\tK14237 tRNA-Val; tRNA Val" }, { "name":"MSIM_t00180 tRNA-Sec\tK14238 tRNA-Sec; tRNA Sec" }, { "name":"MSIM_r00020 23S ribosomal RNA\tK01980 23SrRNA; 23S ribosomal RNA" }, { "name":"MSIM_r00030 5S ribosomal RNA\tK01985 5SrRNA; 5S ribosomal RNA" }, { "name":"MSIM_tm00010 transfer-messenger RNA\tK15035 ssrA; transfer-messenger RNA" } ] } ] } ] }, { "name":"09190 Not Included in Pathway or Brite", "children":[ { "name":"09191 Unclassified: metabolism", "children":[ { "name":"99980 Enzymes with EC numbers", "children":[ { "name":"MSIM_45050 S-(hydroxymethyl)mycothiol dehydrogenase\tK00153 E1.1.1.306; S-(hydroxymethyl)mycothiol dehydrogenase [EC:1.1.1.306]" }, { "name":"MSIM_26120 decaprenylphospho-beta-D-erythro-pentofuranosid-2 -ulose 2-reductase\tK16652 dprE2; decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase [EC:1.1.1.333]" }, { "name":"MSIM_07990 putative oxidoreductase\tK06221 dkgA; 2,5-diketo-D-gluconate reductase A [EC:1.1.1.346]" }, { "name":"MSIM_08000 putative oxidoreductase\tK06221 dkgA; 2,5-diketo-D-gluconate reductase A [EC:1.1.1.346]" }, { "name":"MSIM_52360 hypothetical protein\tK21416 acoA; acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha [EC:1.1.1.-]" }, { "name":"MSIM_18630 fgd; F420-dependent glucose-6-phosphate dehydrogenase\tK15510 fgd1; coenzyme F420-dependent glucose-6-phosphate dehydrogenase [EC:1.1.98.2]" }, { "name":"MSIM_26130 putative oxidoreductase\tK16653 dprE1; decaprenylphospho-beta-D-ribofuranose 2-oxidase [EC:1.1.98.3]" }, { "name":"MSIM_01310 putative F420H(2)-dependent quinone reductase\tK00540 fqr; F420H(2)-dependent quinone reductase [EC:1.1.98.-]" }, { "name":"MSIM_29310 deazaflavin-dependent nitroreductase\tK00540 fqr; F420H(2)-dependent quinone reductase [EC:1.1.98.-]" }, { "name":"MSIM_39060 putative F420H(2)-dependent quinone reductase\tK00540 fqr; F420H(2)-dependent quinone reductase [EC:1.1.98.-]" }, { "name":"MSIM_40040 nitroreductase\tK00540 fqr; F420H(2)-dependent quinone reductase [EC:1.1.98.-]" }, { "name":"MSIM_37790 NADP-dependent aryl-alcohol dehydrogenase\tK23107 yajO; 1-deoxyxylulose-5-phosphate synthase [EC:1.1.-.-]" }, { "name":"MSIM_19020 carbon monoxyde dehydrogenase small subunit\tK03518 coxS; aerobic carbon-monoxide dehydrogenase small subunit [EC:1.2.5.3]" }, { "name":"MSIM_19030 carbon monoxide dehydrogenase medium subunit\tK03519 coxM; aerobic carbon-monoxide dehydrogenase medium subunit [EC:1.2.5.3]" }, { "name":"MSIM_19010 carbon-monoxide dehydrogenase large subunit\tK03520 coxL; aerobic carbon-monoxide dehydrogenase large subunit [EC:1.2.5.3]" }, { "name":"MSIM_24370 phthiodiolone\/phenolphthiodiolone dimycocerosates ketoreductase\tK14728 K14728; phthiodiolone\/phenolphthiodiolone dimycocerosates ketoreductase [EC:1.2.-.-]" }, { "name":"MSIM_16080 mftC; putative mycofactocin radical SAM maturase MftC\tK24696 mftC; [mycofactocin precursor peptide]-tyrosine decarboxylase \/ 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase [EC:1.3.98.7 4.1.99.26]" }, { "name":"MSIM_16850 oxidoreductase\tK21401 menJ; menaquinone-9 beta-reductase [EC:1.3.99.38]" }, { "name":"MSIM_40100 mbtN; acyl-[acyl-carrier-protein] dehydrogenase MbtN\tK00257 mbtN; acyl-ACP dehydrogenase [EC:1.3.99.-]" }, { "name":"MSIM_16070 mftD; putative mycofactocin system heme\/flavin oxidoreductase MftD\tK24693 mftD; pre-mycofactocin synthase [EC:1.4.3.26]" }, { "name":"MSIM_23910 NADP oxidoreductase\tK06988 fno; 8-hydroxy-5-deazaflavin:NADPH oxidoreductase [EC:1.5.1.40]" }, { "name":"MSIM_13790 lpdA; NAD(P)H-quinone dehydrogenase\tK23842 lpdA; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]" }, { "name":"MSIM_02270 qor; quinone reductase\tK00344 qor; NADPH:quinone reductase [EC:1.6.5.5]" }, { "name":"MSIM_10850 fadB4; NADPH:quinone oxidoreductase\tK00344 qor; NADPH:quinone reductase [EC:1.6.5.5]" }, { "name":"MSIM_26410 alcohol dehydrogenase\tK00344 qor; NADPH:quinone reductase [EC:1.6.5.5]" }, { "name":"MSIM_43920 NADH oxidoreductase\tK00344 qor; NADPH:quinone reductase [EC:1.6.5.5]" }, { "name":"MSIM_06470 mtr; mycothione reductase\tK17883 mtr; mycothione reductase [EC:1.8.1.15]" }, { "name":"MSIM_14290 oxidoreductase\tK22347 nox; 4,4'-dithiodibutanoate disulfide reductase [EC:1.8.1.20]" }, { "name":"MSIM_21880 msrA_1; peptide methionine sulfoxide reductase MsrA\tK07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]" }, { "name":"MSIM_33400 msrA_2; peptide methionine sulfoxide reductase MsrA\tK07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]" }, { "name":"MSIM_49680 msrA_3; peptide methionine sulfoxide reductase MsrA\tK07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]" }, { "name":"MSIM_04750 msrB_1; peptide-methionine (R)-S-oxide reductase\tK07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]" }, { "name":"MSIM_33390 msrB_2; peptide methionine sulfoxide reductase MsrB\tK07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]" }, { "name":"MSIM_49690 putative methionine sulfoxide reductase\tK07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]" }, { "name":"MSIM_32920 glutathione S-transferase\tK07393 ECM4; glutathionyl-hydroquinone reductase [EC:1.8.5.7]" }, { "name":"MSIM_42790 manganese catalase\tK07217 ydbD; manganese catalase [EC:1.11.1.6]" }, { "name":"MSIM_48420 alpha\/beta hydrolase\tK00433 cpo; non-heme chloroperoxidase [EC:1.11.1.10]" }, { "name":"MSIM_00900 bcpB; putative peroxiredoxin\tK03564 BCP; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24]" }, { "name":"MSIM_41020 bcp; putative peroxiredoxin\tK03564 BCP; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24]" }, { "name":"MSIM_50280 tpx; putative thiol peroxidase\tK11065 tpx; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24]" }, { "name":"MSIM_51150 ahpD; alkyl hydroperoxide reductase AhpD\tK04756 ahpD; lipoyl-dependent peroxiredoxin subunit D [EC:1.11.1.28]" }, { "name":"MSIM_51140 ahpC; alkyl hydroperoxide reductase subunit C\tK24126 ahpC; lipoyl-dependent peroxiredoxin subunit C [EC:1.11.1.28]" }, { "name":"MSIM_45230 putative peroxiredoxin\tK24120 ahpE; mycoredoxin-dependent peroxiredoxin [EC:1.11.1.29]" }, { "name":"MSIM_30780 peroxidase\tK07223 yfeX; porphyrinogen peroxidase [EC:1.11.1.-]" }, { "name":"MSIM_21150 putative quercetin 2,3-dioxygenase\tK06911 PIR; quercetin 2,3-dioxygenase [EC:1.13.11.24]" }, { "name":"MSIM_21790 short-chain dehydrogenase\tK06911 PIR; quercetin 2,3-dioxygenase [EC:1.13.11.24]" }, { "name":"MSIM_24710 hypothetical protein\tK06911 PIR; quercetin 2,3-dioxygenase [EC:1.13.11.24]" }, { "name":"MSIM_16320 carotenoid cleavage oxygenase\tK11159 K11159; carotenoid cleavage oxygenase [EC:1.13.11.-]" }, { "name":"MSIM_14600 alpha-ketoglutarate-dependent sulfate ester dioxygenase\tK22303 atsK; alkyl sulfatase [EC:1.14.11.77]" }, { "name":"MSIM_11170 N5,N10-methylene tetrahydromethanopterin reductase\tK20938 ladA; long-chain alkane monooxygenase [EC:1.14.14.28]" }, { "name":"MSIM_28770 TB11.2; heme-degrading monooxygenase HmoB\tK21481 mhuD; heme oxygenase (mycobilin-producing) [EC:1.14.99.57]" }, { "name":"MSIM_10760 fprA; NADPH-ferredoxin reductase FprA\tK00528 fpr; ferredoxin\/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1]" }, { "name":"MSIM_33030 fprB_1; putative ferredoxin\/ferredoxin--NADP reductase\tK00528 fpr; ferredoxin\/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1]" }, { "name":"MSIM_43530 fprB_2; putative ferredoxin\/ferredoxin--NADP reductase\tK00528 fpr; ferredoxin\/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1]" }, { "name":"MSIM_36660 arsC; arsenate reductase (glutaredoxin)\tK00537 arsC; arsenate reductase (glutaredoxin) [EC:1.20.4.1]" }, { "name":"MSIM_12080 NrdH-redoxin\tK18917 mrx1; mycoredoxin [EC:1.20.4.3]" }, { "name":"MSIM_39380 hypothetical protein\tK12140 hyfE; hydrogenase-4 component E [EC:1.-.-.-]" }, { "name":"MSIM_39390 hycQ; hydrogenase HycQ\tK12141 hyfF; hydrogenase-4 component F [EC:1.-.-.-]" }, { "name":"MSIM_16710 oxidoreductase\tK14189 dltE; uncharacterized oxidoreductase [EC:1.-.-.-]" }, { "name":"MSIM_22560 oxidoreductase\tK14189 dltE; uncharacterized oxidoreductase [EC:1.-.-.-]" }, { "name":"MSIM_12400 cyclopropane-fatty-acyl-phospholipid synthase\tK00574 cfa; cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]" }, { "name":"MSIM_16430 mmaA2_1; cyclopropane mycolic acid synthase MmaA2\tK00574 cfa; cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]" }, { "name":"MSIM_26010 mmaA2_3; cyclopropane mycolic acid synthase MmaA2\tK00574 cfa; cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]" }, { "name":"MSIM_27200 putative fatty acid methyltransferase\tK00574 cfa; cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]" }, { "name":"MSIM_53210 cmaB_2; methoxy mycolic acid synthase MmaA3\tK00574 cfa; cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]" }, { "name":"MSIM_19760 tam; putative trans-aconitate 2-methyltransferase\tK00598 tam; trans-aconitate 2-methyltransferase [EC:2.1.1.144]" }, { "name":"MSIM_50040 hypothetical protein\tK24288 meT1; MMP 1-O-methyltransferase [EC:2.1.1.365]" }, { "name":"MSIM_16860 hypothetical protein\tK24667 htm; 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase [EC:2.1.1.374]" }, { "name":"MSIM_01790 methyltransferase MtfB\tK05303 K05303; O-methyltransferase [EC:2.1.1.-]" }, { "name":"MSIM_01820 methyltransferase MtfB\tK05303 K05303; O-methyltransferase [EC:2.1.1.-]" }, { "name":"MSIM_11470 carbamoyltransferase\tK00612 nodU; carbamoyltransferase [EC:2.1.3.-]" }, { "name":"MSIM_46730 mdcH; malonate decarboxylase subunit epsilon\tK13935 mdcH; malonate decarboxylase epsilon subunit [EC:2.3.1.39]" }, { "name":"MSIM_31010 mshD; mycothiol acetyltransferase\tK15520 mshD; mycothiol synthase [EC:2.3.1.189]" }, { "name":"MSIM_47660 hypothetical protein\tK03820 lnt; apolipoprotein N-acyltransferase [EC:2.3.1.269]" }, { "name":"MSIM_42080 hypothetical protein\tK22797 octT; diglucosylglycerate octanoyltransferase [EC:2.3.1.273]" }, { "name":"MSIM_42160 putative conserved polyketide synthase associated protein PapA3\tK23156 papA3; mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase \/ long-chain-acyl-CoA---trehalose acyltransferase [EC:2.3.1.278 2.3.1.279]" }, { "name":"MSIM_07810 papA5; phthiocerol\/phthiodiolone dimycocerosyl transferase\tK23414 papA5; phenolphthiocerol\/phthiocerol\/phthiodiolone dimycocerosyl transferase [EC:2.3.1.282]" }, { "name":"MSIM_09960 siderophore biosynthesis protein\tK21992 mbtK; lysine N-acyltransferase [EC:2.3.1.-]" }, { "name":"MSIM_40110 mbtK; lysine N-acyltransferase MbtK\tK21992 mbtK; lysine N-acyltransferase [EC:2.3.1.-]" }, { "name":"MSIM_42140 PE-PPE domain-containing protein\tK22796 chp2; diacyltrehalose acyltransferase [EC:2.3.1.-]" }, { "name":"MSIM_36070 acetyltransferase Pat\tK22886 K22886; protein lysine acetyltransferase [EC:2.3.1.-]" }, { "name":"MSIM_20470 acyltransferase\tK27307 tmaT; acetyltransferase [EC:2.3.1.-]" }, { "name":"MSIM_08520 GCN5-like N-acetyltransferase\tK22310 olsB; L-ornithine Nalpha-acyltransferase [EC:2.3.2.30]" }, { "name":"MSIM_17670 mshA; D-inositol 3-phosphate glycosyltransferase\tK15521 mshA; D-inositol-3-phosphate glycosyltransferase [EC:2.4.1.250]" }, { "name":"MSIM_46690 mdcB; triphosphoribosyl-dephospho-CoA synthase MdcB\tK13930 mdcB; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52]" }, { "name":"MSIM_00840 hypothetical protein\tK13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145]" }, { "name":"MSIM_08040 hypothetical protein\tK07030 fakA; fatty acid kinase [EC:2.7.2.18]" }, { "name":"MSIM_45500 glnE; glutamate-ammonia-ligase adenylyltransferase\tK00982 glnE; [glutamine synthetase] adenylyltransferase \/ [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase [EC:2.7.7.42 2.7.7.89]" }, { "name":"MSIM_46720 mdcG; malonate decarboxylase holo-ACP synthase\tK13934 mdcG; phosphoribosyl-dephospho-CoA transferase [EC:2.7.7.66]" }, { "name":"MSIM_28820 disA; DNA integrity scanning protein DisA\tK07067 disA; diadenylate cyclase [EC:2.7.7.85]" }, { "name":"MSIM_09990 UPF0061 protein\tK08997 SELENOO; protein adenylyltransferase [EC:2.7.7.108]" }, { "name":"MSIM_38380 hypothetical protein\tK21014 stf0; trehalose 2-sulfotransferase [EC:2.8.2.37]" }, { "name":"MSIM_19190 stf3; PAPS-dependent sulfotransferase Stf3\tK22905 stf3; omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase [EC:2.8.2.40]" }, { "name":"MSIM_07060 CoA transferase\tK18313 sct; succinyl-CoA---D-citramalate CoA-transferase [EC:2.8.3.20]" }, { "name":"MSIM_10880 CoA transferase\tK18313 sct; succinyl-CoA---D-citramalate CoA-transferase [EC:2.8.3.20]" }, { "name":"MSIM_47860 lipT; carboxylic ester hydrolase\tK03929 pnbA; para-nitrobenzyl esterase [EC:3.1.1.-]" }, { "name":"MSIM_12130 lipV; lipase LipV\tK19311 lipV; lipase [EC:3.1.1.-]" }, { "name":"MSIM_15170 cut4; cutinase\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_15180 cut2_1; putative cutinase cut2\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_27030 cut5; cutinase\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_41390 putative cutinase\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_44890 cutinase\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_49860 putative cutinase\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_49900 cutinase\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_50050 cut2_2; putative cutinase cut2\tK27358 cut1_2_4_7; cutinase-like protein [EC:3.1.1.-]" }, { "name":"MSIM_25970 cutinase\tK27360 cut6; phospholipase A\/thioesterase [EC:3.1.1.-]" }, { "name":"MSIM_21340 hypothetical protein\tK07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]" }, { "name":"MSIM_36490 thioesterase\tK07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]" }, { "name":"MSIM_41530 hypothetical protein\tK07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]" }, { "name":"MSIM_41440 plsC; L-3-phosphoserine phosphatase\tK15781 serB-plsC; putative phosphoserine phosphatase \/ 1-acylglycerol-3-phosphate O-acyltransferase [EC:3.1.3.3 2.3.1.51]" }, { "name":"MSIM_21720 ptbB; phosphotyrosine protein phosphatase\tK01104 E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48]" }, { "name":"MSIM_42070 gpgP; glucosyl-3-phosphoglycerate phosphatase\tK22306 gpgP; glucosyl-3-phosphoglycerate phosphatase [EC:3.1.3.85]" }, { "name":"MSIM_25920 phosphatase PAP2 family protein\tK27842 E3.1.3.111; decaprenylphosphoryl-5-phosphoribose phosphatase [EC:3.1.3.111]" }, { "name":"MSIM_39250 hypothetical protein\tK08296 sixA; phosphohistidine phosphatase [EC:3.1.3.-]" }, { "name":"MSIM_26400 hydrolase\tK25227 sdsA1; linear primary-alkylsulfatase [EC:3.1.6.21]" }, { "name":"MSIM_36410 hypothetical protein\tK03424 tatD; TatD DNase family protein [EC:3.1.21.-]" }, { "name":"MSIM_39870 nucS; endonuclease NucS\tK07503 nucS; endonuclease [EC:3.1.-.-]" }, { "name":"MSIM_50030 prenyltransferase\tK27194 mmpH; MMP endo-(1,4)-3-O-methyl-alpha-D-mannosidase [EC:3.2.1.221]" }, { "name":"MSIM_27400 hypothetical protein\tK27495 endoMA; D-arabinan endo alpha-(1,5)-arabinofuranosidase [EC:3.2.1.226]" }, { "name":"MSIM_33280 hypothetical protein\tK27495 endoMA; D-arabinan endo alpha-(1,5)-arabinofuranosidase [EC:3.2.1.226]" }, { "name":"MSIM_16060 mycofactocin system creatininase family protein\tK24697 mftE; mycofactocin precursor peptide peptidase [EC:3.4.14.14]" }, { "name":"MSIM_51540 hypothetical protein\tK24697 mftE; mycofactocin precursor peptide peptidase [EC:3.4.14.14]" }, { "name":"MSIM_18320 def; peptide deformylase\tK01462 PDF; peptide deformylase [EC:3.5.1.88]" }, { "name":"MSIM_38250 mshB; 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase\tK15525 mshB; N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase [EC:3.5.1.103]" }, { "name":"MSIM_37170 mca; mycothiol S-conjugate amidase\tK18455 mca; mycothiol S-conjugate amidase [EC:3.5.1.115]" }, { "name":"MSIM_17730 hydrolase\tK11206 NIT1; deaminated glutathione amidase [EC:3.5.1.128]" }, { "name":"MSIM_52430 nitrile hydratase subunit beta\tK20760 scnA; thiocyanate hydrolase subunit alpha [EC:3.5.5.8]" }, { "name":"MSIM_52440 thiocyanate hydrolase subunit gamma\tK20762 scnC; thiocyanate hydrolase subunit gamma [EC:3.5.5.8]" }, { "name":"MSIM_02030 moxR1; ATPase\tK03924 moxR; MoxR-like ATPase [EC:3.6.3.-]" }, { "name":"MSIM_11100 moxR3; methanol dehydrogenase transcriptional regulator MoxR\tK03924 moxR; MoxR-like ATPase [EC:3.6.3.-]" }, { "name":"MSIM_27580 moxR2; ATPase AAA\tK03924 moxR; MoxR-like ATPase [EC:3.6.3.-]" }, { "name":"MSIM_43980 moxR; ATPase AAA\tK03924 moxR; MoxR-like ATPase [EC:3.6.3.-]" }, { "name":"MSIM_46710 mdcE; biotin-independent malonate decarboxylase subunit beta\tK13932 mdcD; malonate decarboxylase beta subunit [EC:4.1.1.87]" }, { "name":"MSIM_32580 kdc; alpha-keto-acid decarboxylase\tK21431 kdc; alpha-keto-acid decarboxylase [EC:4.1.1.-]" }, { "name":"MSIM_14920 bifunctional NAD(P)H-hydrate repair enzyme\tK23997 nnr; ADP-dependent NAD(P)H-hydrate dehydratase \/ NAD(P)H-hydrate epimerase [EC:4.2.1.136 5.1.99.6]" }, { "name":"MSIM_37940 enoyl-CoA hydratase\tK08299 caiD; crotonobetainyl-CoA hydratase [EC:4.2.1.149]" }, { "name":"MSIM_29600 echA19; enoyl-CoA hydratase\tK28233 echA19; 3-oxochol-4,22-dien-24-oyl-CoA hydratase (R-form) [EC:4.2.1.-]" }, { "name":"MSIM_40890 ATP-dependent acyl-CoA ligase\tK02182 caiC; carnitine-CoA ligase [EC:6.2.1.48]" }, { "name":"MSIM_46870 mshC; L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase\tK15526 mshC; L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase [EC:6.3.1.13]" }, { "name":"MSIM_34880 accD2; acetyl-CoA carboxylase carboxyltransferase subunit\tK01970 accD2; acyl-CoA carboxylase subunit beta [EC:6.4.1.-]" }, { "name":"MSIM_33150 accD3; putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta\tK04104 accD3; acyl-CoA carboxylase subunit beta [EC:6.4.1.-]" }, { "name":"MSIM_34860 accA2; acetyl\/propionyl-CoA carboxylase subuit alpha\tK27596 accA2; acyl-CoA carboxylase subunit alpha [EC:6.4.1.-]" }, { "name":"MSIM_48450 ctpV; putative copper-exporting P-type ATPase V\tK12956 ctpV; copper-transporting P-type ATPase V [EC:7.2.2.8]" }, { "name":"MSIM_13180 ctpC; putative manganese\/zinc-exporting P-type ATPase\tK12950 ctpC; manganese-transporting P-type ATPase C [EC:7.2.2.22]" }, { "name":"MSIM_35970 ctpD; putative cobalt\/nickel-exporting P-type ATPase\tK12951 ctpD; cobalt\/nickel-transporting P-type ATPase D [EC:7.2.2.-]" }, { "name":"MSIM_33200 ctpE; putative cation-transporting ATPase E\tK12952 ctpE; cation-transporting P-type ATPase E [EC:7.2.2.-]" }, { "name":"MSIM_22460 ctpI; haloacid dehalogenase\tK12955 ctpI; cation-transporting P-type ATPase I [EC:7.2.2.-]" } ] }, { "name":"99981 Carbohydrate metabolism" }, { "name":"99982 Energy metabolism", "children":[ { "name":"MSIM_07290 fdhD; sulfurtransferase FdhD\tK02379 fdhD; FdhD protein" }, { "name":"MSIM_10360 fer; ferredoxin\tK05337 fer; ferredoxin" }, { "name":"MSIM_29700 fdxD; ferredoxin FdxD\tK05337 fer; ferredoxin" }, { "name":"MSIM_32000 ferredoxin\tK05337 fer; ferredoxin" }, { "name":"MSIM_32020 ferredoxin\tK05337 fer; ferredoxin" }, { "name":"MSIM_32080 hypothetical protein\tK05337 fer; ferredoxin" }, { "name":"MSIM_32270 ferredoxin\tK05337 fer; ferredoxin" }, { "name":"MSIM_40860 ferredoxin\tK05337 fer; ferredoxin" }, { "name":"MSIM_02160 iron-sulfur cluster assembly scaffold protein NifU\tK04488 iscU; nitrogen fixation protein NifU and related proteins" }, { "name":"MSIM_37860 hypothetical protein\tK02448 norD; nitric oxide reductase NorD protein" }, { "name":"MSIM_47760 hypothetical protein\tK02448 norD; nitric oxide reductase NorD protein" }, { "name":"MSIM_32470 ctaE_1; cytochrome b6\tK02164 norE; nitric oxide reductase NorE protein" }, { "name":"MSIM_37870 cbbQ; CbbQ\/NirQ\/NorQ\/GpvN family protein\tK04748 norQ; nitric oxide reductase NorQ protein" }, { "name":"MSIM_47750 norQ; CbbQ\/NirQ\/NorQ\/GpvN family protein\tK04748 norQ; nitric oxide reductase NorQ protein" }, { "name":"MSIM_08540 etfB; electron transfer flavoprotein subunit beta\tK03521 fixA; electron transfer flavoprotein beta subunit" } ] }, { "name":"99983 Lipid metabolism", "children":[ { "name":"MSIM_16270 fadE8; acyl-CoA dehydrogenase\tK09456 aidB; putative acyl-CoA dehydrogenase" }, { "name":"MSIM_01560 MbtH-like protein\tK16227 gplH; glycopeptidolipid biosynthesis protein" }, { "name":"MSIM_01550 putative non-ribosomal peptide synthetase\tK16228 mps1; glycopeptidolipid biosynthesis protein" }, { "name":"MSIM_01540 non-ribosomal peptide synthetase\tK16229 mps2; glycopeptidolipid biosynthesis protein" }, { "name":"MSIM_11820 non-ribosomal peptide synthetase\tK16229 mps2; glycopeptidolipid biosynthesis protein" }, { "name":"MSIM_49020 hypothetical protein\tK22618 olsE; ornithine lipid hydroxylase" }, { "name":"MSIM_42090 DegV domain-containing protein\tK25232 fakB; fatty acid kinase fatty acid binding subunit" } ] }, { "name":"99984 Nucleotide metabolism", "children":[ { "name":"MSIM_09290 nrdI; protein NrdI\tK03647 nrdI; protein involved in ribonucleotide reduction" } ] }, { "name":"99985 Amino acid metabolism", "children":[ { "name":"MSIM_46370 UPF0001 protein\tK06997 yggS; PLP dependent protein" } ] }, { "name":"99986 Glycan metabolism", "children":[ { "name":"MSIM_32850 hypothetical protein\tK21687 rpfA; resuscitation-promoting factor RpfA" }, { "name":"MSIM_36420 rpfB; resuscitation-promoting factor RpfB\tK21688 rpfB; resuscitation-promoting factor RpfB" }, { "name":"MSIM_50880 hypothetical protein\tK21689 rpfC; resuscitation-promoting factor RpfC" }, { "name":"MSIM_41750 hypothetical protein\tK21691 rpfE; resuscitation-promoting factor RpfE" }, { "name":"MSIM_16650 integral membrane protein\tK07027 K07027; glycosyltransferase 2 family protein" }, { "name":"MSIM_28330 transferase\tK22907 ppgS; polyprenyl-phospho-N-acetylgalactosaminyl synthase" }, { "name":"MSIM_16050 glycosyl transferase family 2\tK24698 mftF; mycofactocin glycosyltransferase" } ] }, { "name":"99987 Cofactor metabolism", "children":[ { "name":"MSIM_16090 mftB; putative mycofactocin system protein MftB\tK24695 mftB; mycofactocin biosynthesis protein MftB" } ] }, { "name":"99988 Secondary metabolism", "children":[ { "name":"MSIM_13730 lpqC; esterase\tK03932 lpqC; polyhydroxybutyrate depolymerase" }, { "name":"MSIM_21570 alpha\/beta hydrolase\tK24084 aidA; quorum-quenching protein AidA" } ] }, { "name":"99999 Others", "children":[ { "name":"MSIM_09840 glyoxalase\tK15975 K15975; glyoxalase family protein" }, { "name":"MSIM_08340 membrane protein\tK15977 K15977; putative oxidoreductase" }, { "name":"MSIM_09630 membrane protein\tK15977 K15977; putative oxidoreductase" }, { "name":"MSIM_37660 hypothetical protein\tK15977 K15977; putative oxidoreductase" } ] } ] }, { "name":"09192 Unclassified: genetic information processing", "children":[ { "name":"99973 Transcription", "children":[ { "name":"MSIM_23830 cold-shock protein\tK03704 cspA; cold shock protein" }, { "name":"MSIM_28240 cspA; cold-shock protein\tK03704 cspA; cold shock protein" }, { "name":"MSIM_32900 cold-shock protein\tK03704 cspA; cold shock protein" }, { "name":"MSIM_53440 cold-shock protein\tK03704 cspA; cold shock protein" } ] }, { "name":"99974 Translation" }, { "name":"99975 Protein processing", "children":[ { "name":"MSIM_39960 clpS; ATP-dependent Clp protease adapter protein ClpS\tK06891 clpS; ATP-dependent Clp protease adaptor protein ClpS" }, { "name":"MSIM_41670 tig; trigger factor\tK03545 tig; trigger factor" }, { "name":"MSIM_51610 ureF; urease accessory protein UreF\tK03188 ureF; urease accessory protein" }, { "name":"MSIM_51470 ureG; urease accessory protein UreG\tK03189 ureG; urease accessory protein" }, { "name":"MSIM_51460 ureD; urease accessory protein UreD\tK03190 ureD; urease accessory protein" }, { "name":"MSIM_10700 smpB; SsrA-binding protein\tK03664 smpB; SsrA-binding protein" }, { "name":"MSIM_06590 hypC_1; hydantoin utilization protein C\tK04653 hypC; hydrogenase expression\/formation protein HypC" }, { "name":"MSIM_06640 hypC_2; hydrogenase assembly protein HupF\tK04653 hypC; hydrogenase expression\/formation protein HypC" }, { "name":"MSIM_06650 hypD; hydrogenase formation protein HypD\tK04654 hypD; hydrogenase expression\/formation protein HypD" }, { "name":"MSIM_06630 hypE; hydrogenase expression\/formation protein HypE\tK04655 hypE; hydrogenase expression\/formation protein HypE" }, { "name":"MSIM_06600 hypF; carbamoyltransferase\tK04656 hypF; hydrogenase maturation protein HypF" }, { "name":"MSIM_09300 nrdH; NrdH-redoxin\tK06191 nrdH; glutaredoxin-like protein NrdH" }, { "name":"MSIM_07270 hypothetical protein\tK07391 comM; magnesium chelatase family protein" }, { "name":"MSIM_17210 cytochrome c biogenesis protein\tK07399 resB; cytochrome c biogenesis protein" }, { "name":"MSIM_19000 hypothetical protein\tK07402 xdhC; xanthine dehydrogenase accessory factor" }, { "name":"MSIM_19040 hypothetical protein\tK07402 xdhC; xanthine dehydrogenase accessory factor" } ] }, { "name":"99976 Replication and repair", "children":[ { "name":"MSIM_12140 DNA methyltransferase\tK07443 ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein" }, { "name":"MSIM_07280 UPF0102 protein\tK07460 yraN; putative endonuclease" }, { "name":"MSIM_47100 hypothetical protein\tK07465 K07465; putative RecB family exonuclease" }, { "name":"MSIM_07080 dprA; putative DNA processing protein DprA\tK04096 smf; DNA processing protein" }, { "name":"MSIM_03370 ATPase AAA\tK07478 ycaJ; putative ATPase" }, { "name":"MSIM_27170 IS30 family transposase\tK07482 K07482; transposase, IS30 family" }, { "name":"MSIM_48820 hypothetical protein\tK07483 K07483; transposase" }, { "name":"MSIM_53640 hypothetical protein\tK07497 K07497; putative transposase" }, { "name":"MSIM_53650 transposase\tK07497 K07497; putative transposase" } ] }, { "name":"99979 Viral proteins" }, { "name":"99998 Others", "children":[ { "name":"MSIM_05360 35 kDa protein\tK03969 pspA; phage shock protein A" }, { "name":"MSIM_27280 nucleoid-associated protein\tK09747 ebfC; nucleoid-associated protein EbfC" } ] } ] }, { "name":"09193 Unclassified: signaling and cellular processes", "children":[ { "name":"99977 Transport", "children":[ { "name":"MSIM_12990 cationic amino acid transport integral membrane protein\tK03294 TC.APA; basic amino acid\/polyamine antiporter, APA family" }, { "name":"MSIM_17080 putative transporter\tK03294 TC.APA; basic amino acid\/polyamine antiporter, APA family" }, { "name":"MSIM_43320 rocE; amino acid permease\tK03294 TC.APA; basic amino acid\/polyamine antiporter, APA family" }, { "name":"MSIM_17030 pit; putative low-affinity inorganic phosphate transporter\tK03306 TC.PIT; inorganic phosphate transporter, PiT family" }, { "name":"MSIM_41340 transporter\tK03453 TC.BASS; bile acid:Na+ symporter, BASS family" } ] }, { "name":"99978 Cell growth", "children":[ { "name":"MSIM_25150 hypothetical protein\tK06346 jag; spoIIIJ-associated protein" } ] }, { "name":"99993 Cell motility" }, { "name":"99995 Signaling proteins", "children":[ { "name":"MSIM_38220 GTP-binding protein\tK06207 typA; GTP-binding protein" }, { "name":"MSIM_42720 PhoH-like protein\tK06217 phoH; phosphate starvation-inducible protein PhoH and related proteins" }, { "name":"MSIM_37300 phoH2; ATP-binding protein\tK07175 phoH2; PhoH-like ATPase" }, { "name":"MSIM_16800 UPF0234 protein\tK09767 yajQ; cyclic-di-GMP-binding protein" } ] }, { "name":"99992 Structural proteins", "children":[ { "name":"MSIM_28320 membrane protein\tK09153 K09153; small membrane protein" } ] }, { "name":"99994 Others", "children":[ { "name":"MSIM_04540 phoU2_1; phosphate transport system regulatory protein PhoU\tK02039 phoU; phosphate transport system protein" }, { "name":"MSIM_04570 phoU2_2; phosphate transport system regulatory protein PhoU\tK02039 phoU; phosphate transport system protein" }, { "name":"MSIM_31060 phoU2_3; phosphate transport system regulatory protein PhoU\tK02039 phoU; phosphate transport system protein" }, { "name":"MSIM_32570 (2Fe-2S)-binding protein\tK02192 bfd; bacterioferritin-associated ferredoxin" }, { "name":"MSIM_51090 hypothetical protein\tK02192 bfd; bacterioferritin-associated ferredoxin" }, { "name":"MSIM_30360 FAD-dependent oxidoreductase\tK07222 K07222; putative flavoprotein involved in K+ transport" }, { "name":"MSIM_11250 hypothetical protein\tK20467 K20467; heme-binding protein" }, { "name":"MSIM_20820 hypothetical protein\tK20467 K20467; heme-binding protein" } ] } ] }, { "name":"09194 Poorly characterized", "children":[ { "name":"99996 General function prediction only", "children":[ { "name":"MSIM_06440 UPF0039 protein\tK02348 elaA; ElaA protein" }, { "name":"MSIM_25490 PHP domain-containing protein\tK04477 ycdX; putative hydrolase" }, { "name":"MSIM_28230 helicase\tK06877 K06877; DEAD\/DEAH box helicase domain-containing protein" }, { "name":"MSIM_01400 glbN; group 1 truncated hemoglobin GlbN\tK06886 glbN; hemoglobin" }, { "name":"MSIM_33320 hypothetical protein\tK06886 glbN; hemoglobin" }, { "name":"MSIM_41570 glbO; group 2 truncated hemoglobin GlbO\tK06886 glbN; hemoglobin" }, { "name":"MSIM_01580 membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_01590 transporter\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_08420 mmpL6_1; membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_08700 membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_09240 putative membrane protein, MmpL family\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_10020 mmpL4_1; siderophore exporter MmpL4\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_18010 mmpL4_2; membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_24000 putative membrane protein, MmpL family\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_33700 mmpL6_2; membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_36510 putative membrane protein, MmpL family\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_38040 mmpL13_1; membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_41160 mmpL13_2; membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_42100 membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_42150 putative membrane protein, MmpL family\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_42510 putative membrane protein, MmpL family\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_43810 mmpL6_3; membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_48290 membrane protein\tK06994 K06994; putative drug exporter of the RND superfamily" }, { "name":"MSIM_16610 membrane protein\tK07001 K07001; NTE family protein" }, { "name":"MSIM_37000 hypothetical protein\tK07001 K07001; NTE family protein" }, { "name":"MSIM_37010 putative NTE family protein\tK07001 K07001; NTE family protein" }, { "name":"MSIM_47990 membrane protein\tK07001 K07001; NTE family protein" }, { "name":"MSIM_02200 sufB; Fe-S cluster assembly protein SufB\tK09014 sufB; Fe-S cluster assembly protein SufB" }, { "name":"MSIM_02190 UPF0051 protein\tK09015 sufD; Fe-S cluster assembly protein SufD" }, { "name":"MSIM_20440 php; phosphotriesterase\tK07048 PTER; phosphotriesterase-related protein" }, { "name":"MSIM_02140 hypothetical protein\tK07058 K07058; membrane protein" }, { "name":"MSIM_05040 hypothetical protein\tK07058 K07058; membrane protein" }, { "name":"MSIM_14140 inner membrane protein YhjD\tK07058 K07058; membrane protein" }, { "name":"MSIM_46420 hypothetical protein\tK07100 K07100; putative phosphoribosyl transferase" }, { "name":"MSIM_47640 fxsA; membrane protein FxsA\tK07113 fxsA; UPF0716 protein FxsA" }, { "name":"MSIM_13630 putative SufE-like protein\tK02426 sufE; cysteine desulfuration protein SufE" }, { "name":"MSIM_33040 hypothetical protein\tK04750 phnB; PhnB protein" }, { "name":"MSIM_18890 putative membrane protein\tK03975 dedA; membrane-associated protein" }, { "name":"MSIM_40620 hypothetical protein\tK01421 yhgE; putative membrane protein" }, { "name":"MSIM_50660 membrane protein\tK08972 K08972; putative membrane protein" }, { "name":"MSIM_03940 membrane protein\tK08987 K08987; putative membrane protein" }, { "name":"MSIM_44040 UPF0225 protein\tK09858 K09858; SEC-C motif domain protein" } ] }, { "name":"99997 Function unknown", "children":[ { "name":"MSIM_20780 hypothetical protein\tK06860 K06860; putative heme uptake system protein" }, { "name":"MSIM_37190 hypothetical protein\tK06888 K06888; uncharacterized protein" }, { "name":"MSIM_03090 hypothetical protein\tK06893 K06893; uncharacterized protein" }, { "name":"MSIM_21830 hypothetical protein\tK06893 K06893; uncharacterized protein" }, { "name":"MSIM_14330 ATP\/GTP-binding protein\tK06945 K06945; uncharacterized protein" }, { "name":"MSIM_07390 UPF0109 protein\tK06960 K06960; uncharacterized protein" }, { "name":"MSIM_24720 N-acetyltransferase\tK06975 K06975; uncharacterized protein" }, { "name":"MSIM_33730 hypothetical protein\tK06975 K06975; uncharacterized protein" }, { "name":"MSIM_06760 N-acetyltransferase GCN5\tK06976 K06976; uncharacterized protein" }, { "name":"MSIM_06020 hydrolase\tK06978 K06978; uncharacterized protein" }, { "name":"MSIM_30540 hypothetical protein\tK06986 K06986; uncharacterized protein" }, { "name":"MSIM_01290 hypothetical protein\tK07005 K07005; uncharacterized protein" }, { "name":"MSIM_10790 pyridoxamine 5'-phosphate oxidase\tK07005 K07005; uncharacterized protein" }, { "name":"MSIM_02680 pyridoxamine 5'-phosphate oxidase\tK07006 K07006; uncharacterized protein" }, { "name":"MSIM_09720 hypothetical protein\tK07006 K07006; uncharacterized protein" }, { "name":"MSIM_27010 PPOX class F420-dependent oxidoreductase\tK07006 K07006; uncharacterized protein" }, { "name":"MSIM_47610 PPOX class F420-dependent oxidoreductase\tK07006 K07006; uncharacterized protein" }, { "name":"MSIM_49920 hypothetical protein\tK07006 K07006; uncharacterized protein" }, { "name":"MSIM_18400 hypothetical protein\tK07020 K07020; uncharacterized protein" }, { "name":"MSIM_05820 hypothetical protein\tK07044 K07044; uncharacterized protein" }, { "name":"MSIM_19220 amidohydrolase\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_29630 hypothetical protein\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_32130 amidohydrolase\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_32140 amidohydrolase\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_40430 amidohydrolase\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_40660 amidohydrolase\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_40670 amidohydrolase\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_51040 hypothetical protein\tK07045 K07045; uncharacterized protein" }, { "name":"MSIM_03500 hypothetical protein\tK07054 K07054; uncharacterized protein" }, { "name":"MSIM_08580 nucleoside-diphosphate sugar epimerase\tK07071 K07071; uncharacterized protein" }, { "name":"MSIM_45650 epimerase family protein\tK07071 K07071; uncharacterized protein" }, { "name":"MSIM_30550 KsdD-like steroid dehydrogenase\tK07077 K07077; uncharacterized protein" }, { "name":"MSIM_42460 sodium-dependent bicarbonate transport family permease\tK07086 K07086; uncharacterized protein" }, { "name":"MSIM_04290 hypothetical protein\tK07089 K07089; uncharacterized protein" }, { "name":"MSIM_07850 membrane protein\tK07089 K07089; uncharacterized protein" }, { "name":"MSIM_36010 hypothetical protein\tK07089 K07089; uncharacterized protein" }, { "name":"MSIM_04370 UPF0721 transmembrane protein\tK07090 K07090; uncharacterized protein" }, { "name":"MSIM_46240 UPF0721 transmembrane protein\tK07090 K07090; uncharacterized protein" }, { "name":"MSIM_22080 phosphoesterase\tK07095 K07095; uncharacterized protein" }, { "name":"MSIM_27870 hypothetical protein\tK07098 K07098; uncharacterized protein" }, { "name":"MSIM_01380 ketoacyl reductase\tK07124 K07124; uncharacterized protein" }, { "name":"MSIM_10190 dehydrogenase\tK07124 K07124; uncharacterized protein" }, { "name":"MSIM_14350 serine protease inhibitor\tK07131 K07131; uncharacterized protein" }, { "name":"MSIM_49910 molybdenum cofactor biosysynthesis protein\tK07140 K07140; MOSC domain-containing protein" }, { "name":"MSIM_18270 ATP-dependent protease\tK07157 K07157; uncharacterized protein" }, { "name":"MSIM_18960 hypothetical protein\tK07161 K07161; uncharacterized protein" }, { "name":"MSIM_42040 hypothetical protein\tK07161 K07161; uncharacterized protein" }, { "name":"MSIM_45410 hypothetical protein\tK07164 K07164; uncharacterized protein" }, { "name":"MSIM_25130 putative membrane protein insertion efficiency factor\tK08998 K08998; uncharacterized protein" }, { "name":"MSIM_51780 hypothetical protein\tK08999 K08999; uncharacterized protein" }, { "name":"MSIM_36780 hypothetical protein\tK09009 K09009; uncharacterized protein" }, { "name":"MSIM_27620 hypothetical protein\tK09117 K09117; uncharacterized protein" }, { "name":"MSIM_11980 UPF0182 protein\tK09118 K09118; uncharacterized protein" }, { "name":"MSIM_00600 hypothetical protein\tK09146 K09146; uncharacterized protein" }, { "name":"MSIM_50330 hypothetical protein\tK09166 K09166; uncharacterized protein" }, { "name":"MSIM_47120 hypothetical protein\tK09764 K09764; uncharacterized protein" }, { "name":"MSIM_10040 ABC transporter\tK09781 K09781; uncharacterized protein" }, { "name":"MSIM_54200 hypothetical protein\tK09791 K09791; uncharacterized protein" }, { "name":"MSIM_28350 membrane protein\tK09799 K09799; uncharacterized protein" }, { "name":"MSIM_28470 lpqG; SIMPL domain-containing protein\tK09807 K09807; uncharacterized protein" }, { "name":"MSIM_05490 hypothetical protein\tK09927 K09927; uncharacterized protein" }, { "name":"MSIM_17090 hypothetical protein\tK09931 K09931; uncharacterized protein" }, { "name":"MSIM_26540 hypothetical protein\tK09957 K09957; uncharacterized protein" }, { "name":"MSIM_02750 hypothetical protein\tK09958 K09958; uncharacterized protein" }, { "name":"MSIM_21700 hypothetical protein\tK09958 K09958; uncharacterized protein" }, { "name":"MSIM_17930 hypothetical protein\tK09959 K09959; uncharacterized protein" }, { "name":"MSIM_26620 hypothetical protein\tK09966 K09966; uncharacterized protein" }, { "name":"MSIM_48330 hypothetical protein\tK09990 K09990; uncharacterized protein" } ] } ] } ] } ] }