{
	"name":"mthd01002",
	"children":[
	{
		"name":"Aspartic peptidases",
		"children":[
		{
			"name":"Family A1: pepsin family"
		},
		{
			"name":"Family A2: retropepsin family"
		},
		{
			"name":"Family A5: thermopsin family"
		},
		{
			"name":"Family A8: signal peptidase II family",
			"children":[
			{
				"name":"A3224_02720 signal peptidase II\tK03101 lspA; signal peptidase II [EC:3.4.23.36]"
			}
			]
		},
		{
			"name":"Family A22: presenilin family"
		},
		{
			"name":"Family A24: type IV prepilin peptidase family",
			"children":[
			{
				"name":"A3224_05290 methyltransferase\tK02654 pilD; leader peptidase (prepilin peptidase) \/ N-methyltransferase [EC:3.4.23.43 2.1.1.-]"
			}
			]
		},
		{
			"name":"Family A25: gpr protease family"
		},
		{
			"name":"Family A26: omptin family"
		},
		{
			"name":"Family A28"
		},
		{
			"name":"Family A31: HybD endopeptidase family"
		},
		{
			"name":"Family A36"
		}
		]
	},
	{
		"name":"Cysteine peptidases",
		"children":[
		{
			"name":"Family C1: papain family"
		},
		{
			"name":"Family C2: calpain family"
		},
		{
			"name":"Family C3: picornain family"
		},
		{
			"name":"Family C4: NIa protease family"
		},
		{
			"name":"Family C5"
		},
		{
			"name":"Family C9"
		},
		{
			"name":"Family C10: streptopain family"
		},
		{
			"name":"Family C11: clostripain family"
		},
		{
			"name":"Family C12: ubiquitin C-terminal hydrolase family"
		},
		{
			"name":"Family C13: legumain family"
		},
		{
			"name":"Family C14: caspase family"
		},
		{
			"name":"Family C15: pyroglutamyl peptidase I family"
		},
		{
			"name":"Family C16"
		},
		{
			"name":"Family C19: ubiquitin-specific protease family"
		},
		{
			"name":"Family C25: gingipain family"
		},
		{
			"name":"Family C26: gamma-glutamyl hydrolase family",
			"children":[
			{
				"name":"A3224_05990 guaA; glutamine-hydrolyzing GMP synthase\tK01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]"
			}
			]
		},
		{
			"name":"Family C27"
		},
		{
			"name":"Family C30"
		},
		{
			"name":"Family C37"
		},
		{
			"name":"Family C39"
		},
		{
			"name":"Family C40"
		},
		{
			"name":"Family C44",
			"children":[
			{
				"name":"A3224_05730 amidophosphoribosyltransferase\tK00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]"
			},
			{
				"name":"A3224_01085 gltB; glutamate synthase\tK00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]"
			},
			{
				"name":"A3224_04740 glutamine--fructose-6-phosphate aminotransferase\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]"
			},
			{
				"name":"A3224_16165 glutamine--fructose-6-phosphate aminotransferase\tK00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]"
			}
			]
		},
		{
			"name":"Family C45"
		},
		{
			"name":"Family C46: hedgehog family"
		},
		{
			"name":"Family C47: staphopain family"
		},
		{
			"name":"Family C48: Ulp1 endopeptidase family"
		},
		{
			"name":"Family C50: separase family"
		},
		{
			"name":"Family C54: Aut2 peptidase family"
		},
		{
			"name":"Family C55: YopJ protease family"
		},
		{
			"name":"Family C56: PfpI endopeptidase family"
		},
		{
			"name":"Family C57: vaccinia virus I7 peptidase family"
		},
		{
			"name":"Family C58"
		},
		{
			"name":"Family C59"
		},
		{
			"name":"Family C60",
			"children":[
			{
				"name":"A3224_12380 class GN sortase\tK07284 srtA; sortase A [EC:3.4.22.70]"
			}
			]
		},
		{
			"name":"Family C63"
		},
		{
			"name":"Family C64"
		},
		{
			"name":"Family C65"
		},
		{
			"name":"Family C67"
		},
		{
			"name":"Family C69"
		},
		{
			"name":"Family C70"
		},
		{
			"name":"Family C75"
		},
		{
			"name":"Family C76"
		},
		{
			"name":"Family C78"
		},
		{
			"name":"Family C79"
		},
		{
			"name":"Family C82",
			"children":[
			{
				"name":"A3224_14045 peptidoglycan-binding protein\tK21470 ldtD; L,D-transpeptidase"
			},
			{
				"name":"A3224_14055 peptidoglycan-binding protein\tK21470 ldtD; L,D-transpeptidase"
			}
			]
		},
		{
			"name":"Family C83"
		},
		{
			"name":"Family C85"
		},
		{
			"name":"Family C86"
		},
		{
			"name":"Family C88"
		},
		{
			"name":"Family C89"
		},
		{
			"name":"Family C97"
		},
		{
			"name":"Family C98"
		},
		{
			"name":"Family C110"
		}
		]
	},
	{
		"name":"Glutamic peptidases",
		"children":[
		{
			"name":"Family G1"
		},
		{
			"name":"Family G4"
		},
		{
			"name":"Family G5: prenyl protease 2 family",
			"children":[
			{
				"name":"A3224_00260 hypothetical protein\tK07052 K07052; CAAX protease family protein"
			},
			{
				"name":"A3224_02035 hypothetical protein\tK07052 K07052; CAAX protease family protein"
			},
			{
				"name":"A3224_09040 hypothetical protein\tK07052 K07052; CAAX protease family protein"
			}
			]
		}
		]
	},
	{
		"name":"Metallo peptidases",
		"children":[
		{
			"name":"Family M1",
			"children":[
			{
				"name":"A3224_01620 aminopeptidase\tK01254 LTA4H; leukotriene-A4 hydrolase [EC:3.3.2.6]"
			},
			{
				"name":"A3224_10490 pepN; aminopeptidase N\tK01256 pepN; aminopeptidase N [EC:3.4.11.2]"
			},
			{
				"name":"A3224_14240 aminopeptidase N\tK01256 pepN; aminopeptidase N [EC:3.4.11.2]"
			}
			]
		},
		{
			"name":"Family M2",
			"children":[
			{
				"name":"A3224_10760 peptidyl-dipeptidase\tK01283 ACE; peptidyl-dipeptidase A [EC:3.4.15.1]"
			}
			]
		},
		{
			"name":"Family M3",
			"children":[
			{
				"name":"A3224_00185 oligopeptidase A\tK01414 prlC; oligopeptidase A [EC:3.4.24.70]"
			},
			{
				"name":"A3224_07150 peptidase M3\tK01284 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]"
			},
			{
				"name":"A3224_12580 dipeptidyl carboxypeptidase\tK01284 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]"
			}
			]
		},
		{
			"name":"Family M4: thermolysin family"
		},
		{
			"name":"Family M5: mycolysin family"
		},
		{
			"name":"Family M6: immune inhibitor A family"
		},
		{
			"name":"Family M7: snapalysin family"
		},
		{
			"name":"Family M8: leishmanolysin family"
		},
		{
			"name":"Family M9"
		},
		{
			"name":"Family M10"
		},
		{
			"name":"Family M12: astacin\/adamalysin family"
		},
		{
			"name":"Family M13: neprilysin family",
			"children":[
			{
				"name":"A3224_02930 peptidase M13\tK07386 pepO; putative endopeptidase [EC:3.4.24.-]"
			}
			]
		},
		{
			"name":"Family M14: carboxypeptidase A family"
		},
		{
			"name":"Family M15: zinc D-Ala-D-Ala carboxypeptidase family"
		},
		{
			"name":"Family M16: pitrilysin family",
			"children":[
			{
				"name":"A3224_07380 peptidase M16\tK06972 PITRM1; presequence protease [EC:3.4.24.-]"
			},
			{
				"name":"A3224_14460 peptidase M16\tK07263 pqqL; zinc protease [EC:3.4.24.-]"
			}
			]
		},
		{
			"name":"Family M17: leucyl aminopeptidase family",
			"children":[
			{
				"name":"A3224_11205 leucyl aminopeptidase\tK01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]"
			},
			{
				"name":"A3224_01795 aminopeptidase PepB\tK07751 pepB; PepB aminopeptidase [EC:3.4.11.23]"
			}
			]
		},
		{
			"name":"Family M18"
		},
		{
			"name":"Family M19: membrane dipeptidase family"
		},
		{
			"name":"Family M20",
			"children":[
			{
				"name":"A3224_06095 succinyl-diaminopimelate desuccinylase\tK01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]"
			},
			{
				"name":"A3224_06725 aminoacyl-histidine dipeptidase\tK01270 pepD; dipeptidase D [EC:3.4.13.-]"
			}
			]
		},
		{
			"name":"Family M23"
		},
		{
			"name":"Family M24",
			"children":[
			{
				"name":"A3224_06125 type I methionyl aminopeptidase\tK01265 map; methionyl aminopeptidase [EC:3.4.11.18]"
			},
			{
				"name":"A3224_11565 Xaa-Pro dipeptidase\tK01271 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]"
			},
			{
				"name":"A3224_02895 peptidase M24\tK01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]"
			},
			{
				"name":"A3224_14130 Xaa-Pro aminopeptidase\tK01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]"
			}
			]
		},
		{
			"name":"Family M26"
		},
		{
			"name":"Family M27"
		},
		{
			"name":"Family M28: aminopeptidase Y family"
		},
		{
			"name":"Family M29: aminopeptidase T family"
		},
		{
			"name":"Family M32: carboxypeptidase Taq family"
		},
		{
			"name":"Family M34: anthrax lethal factor family"
		},
		{
			"name":"Family M35: deuterolysin family"
		},
		{
			"name":"Family M36: fungalysin family"
		},
		{
			"name":"Family M38: beta-aspartyl dipeptidase family"
		},
		{
			"name":"Family M41: FtsH endopeptidase family",
			"children":[
			{
				"name":"A3224_03800 hflB; ATP-dependent metalloprotease\tK03798 ftsH; cell division protease FtsH [EC:3.4.24.-]"
			},
			{
				"name":"A3224_09780 cell division protein FtsH\tK03798 ftsH; cell division protease FtsH [EC:3.4.24.-]"
			}
			]
		},
		{
			"name":"Family M42: glutamyl aminopeptidase family"
		},
		{
			"name":"Family M43: cytophagalysin family"
		},
		{
			"name":"Family M44"
		},
		{
			"name":"Family M48: Ste24 endopeptidase family",
			"children":[
			{
				"name":"A3224_04185 zinc metalloprotease HtpX\tK03799 htpX; heat shock protein HtpX [EC:3.4.24.-]"
			},
			{
				"name":"A3224_03440 peptidase M48\tK01423 bepA; beta-barrel assembly-enhancing protease [EC:3.4.-.-]"
			}
			]
		},
		{
			"name":"Family M49: dipeptidyl-peptidase III family"
		},
		{
			"name":"Family M50: S2P protease family",
			"children":[
			{
				"name":"A3224_06165 zinc metallopeptidase RseP\tK11749 rseP; regulator of sigma E protease [EC:3.4.24.-]"
			}
			]
		},
		{
			"name":"Family M54"
		},
		{
			"name":"Family M55: DppA aminopeptidase family"
		},
		{
			"name":"Family M56"
		},
		{
			"name":"Family M67"
		},
		{
			"name":"Family M72"
		},
		{
			"name":"Family M73"
		},
		{
			"name":"Family M74",
			"children":[
			{
				"name":"A3224_12500 penicillin-insensitive murein endopeptidase\tK07261 mepA; penicillin-insensitive murein DD-endopeptidase [EC:3.4.24.-]"
			}
			]
		},
		{
			"name":"Family M80"
		},
		{
			"name":"Family M82"
		},
		{
			"name":"Family M85"
		},
		{
			"name":"Family M88"
		},
		{
			"name":"Family M90",
			"children":[
			{
				"name":"A3224_09865 hypothetical protein\tK09933 mtfA; MtfA peptidase"
			}
			]
		},
		{
			"name":"Family M98"
		}
		]
	},
	{
		"name":"Asparagine peptide lyases",
		"children":[
		{
			"name":"Family N1"
		},
		{
			"name":"Family N8"
		}
		]
	},
	{
		"name":"Mixed peptidases",
		"children":[
		{
			"name":"Family P1: DmpA aminopeptidase family"
		},
		{
			"name":"Family P2"
		}
		]
	},
	{
		"name":"Serine peptidases",
		"children":[
		{
			"name":"Family S1: chymotrypsin family",
			"children":[
			{
				"name":"A3224_06420 serine peptidase\tK04771 degP; serine protease Do [EC:3.4.21.107]"
			},
			{
				"name":"A3224_05080 2-alkenal reductase\tK04691 hhoB; serine protease DegS [EC:3.4.21.-]"
			}
			]
		},
		{
			"name":"Family S3: togavirin family"
		},
		{
			"name":"Family S6"
		},
		{
			"name":"Family S7: flavivirin family"
		},
		{
			"name":"Family S8: subtilisin family",
			"children":[
			{
				"name":"A3224_15885 peptidase S8\tK14645 K14645; serine protease [EC:3.4.21.-]"
			}
			]
		},
		{
			"name":"Family S9: prolyl oligopeptidase family",
			"children":[
			{
				"name":"A3224_04320 prolyl endopeptidase\tK01322 PREP; prolyl oligopeptidase [EC:3.4.21.26]"
			},
			{
				"name":"A3224_07585 hypothetical protein\tK01322 PREP; prolyl oligopeptidase [EC:3.4.21.26]"
			},
			{
				"name":"A3224_03480 peptidase S9\tK01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5]"
			}
			]
		},
		{
			"name":"Family S10"
		},
		{
			"name":"Family S11: D-Ala-D-Ala carboxypeptidase A family",
			"children":[
			{
				"name":"A3224_04300 D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]"
			}
			]
		},
		{
			"name":"Family S12: D-Ala-D-Ala carboxypeptidase B family",
			"children":[
			{
				"name":"A3224_04085 penicillin binding protein PBP4B\tK21469 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4]"
			}
			]
		},
		{
			"name":"Family S13: D-Ala-D-Ala peptidase C family"
		},
		{
			"name":"Family S14: ClpP endopeptidase family",
			"children":[
			{
				"name":"A3224_09195 ATP-dependent Clp protease proteolytic subunit\tK01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]"
			}
			]
		},
		{
			"name":"Family S15"
		},
		{
			"name":"Family S16: lon protease family",
			"children":[
			{
				"name":"A3224_09185 endopeptidase La\tK01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]"
			}
			]
		},
		{
			"name":"Family S21: assemblin family"
		},
		{
			"name":"Family S24: LexA family",
			"children":[
			{
				"name":"A3224_08655 LexA repressor\tK01356 lexA; repressor LexA [EC:3.4.21.88]"
			}
			]
		},
		{
			"name":"Family S26: signal peptidase I family",
			"children":[
			{
				"name":"A3224_06430 S26 family signal peptidase\tK03100 lepB; signal peptidase I [EC:3.4.21.89]"
			}
			]
		},
		{
			"name":"Family S28"
		},
		{
			"name":"Family S31"
		},
		{
			"name":"Family S32"
		},
		{
			"name":"Family S33"
		},
		{
			"name":"Family S41: C-terminal processing peptidase family",
			"children":[
			{
				"name":"A3224_08245 peptidase S41\tK03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]"
			},
			{
				"name":"A3224_14935 peptidase S41\tK03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]"
			}
			]
		},
		{
			"name":"Family S45",
			"children":[
			{
				"name":"A3224_08060 penicillin amidase\tK01434 pac; penicillin G amidase [EC:3.5.1.11]"
			}
			]
		},
		{
			"name":"Family S49: protease IV family",
			"children":[
			{
				"name":"A3224_05780 signal peptide peptidase SppA\tK04773 sppA; protease IV [EC:3.4.21.-]"
			},
			{
				"name":"A3224_09125 protease SohB\tK04774 sohB; serine protease SohB [EC:3.4.21.-]"
			}
			]
		},
		{
			"name":"Family S50"
		},
		{
			"name":"Family S51"
		},
		{
			"name":"Family S53"
		},
		{
			"name":"Family S54: Rhomboid family",
			"children":[
			{
				"name":"A3224_14115 hypothetical protein\tK02441 glpG; rhomboid protease GlpG [EC:3.4.21.105]"
			}
			]
		},
		{
			"name":"Family S55: SpoIVB peptidase family"
		},
		{
			"name":"Family S62"
		},
		{
			"name":"Family S66",
			"children":[
			{
				"name":"A3224_10330 LD-carboxypeptidase\tK01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]"
			}
			]
		},
		{
			"name":"Family S77: phage prohead processing peptidase family"
		},
		{
			"name":"Family S78"
		}
		]
	},
	{
		"name":"Threonine peptidases",
		"children":[
		{
			"name":"Family T1: proteasome family",
			"children":[
			{
				"name":"A3224_15670 HslU--HslV peptidase proteolytic subunit\tK01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]"
			}
			]
		},
		{
			"name":"Family T2",
			"children":[
			{
				"name":"A3224_09500 isoaspartyl peptidase\tK13051 ASRGL1; L-asparaginase \/ beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5]"
			}
			]
		},
		{
			"name":"Family T3: gamma-glutamyltransferase family",
			"children":[
			{
				"name":"A3224_15800 gamma-glutamyltransferase\tK00681 ggt; gamma-glutamyltranspeptidase \/ glutathione hydrolase [EC:2.3.2.2 3.4.19.13]"
			}
			]
		}
		]
	},
	{
		"name":"Peptidases of unknown catalytic type",
		"children":[
		{
			"name":"Family U32",
			"children":[
			{
				"name":"A3224_03905 U32 family peptidase\tK08303 prtC; U32 family peptidase [EC:3.4.-.-]"
			},
			{
				"name":"A3224_03955 U32 family peptidase\tK24845 ubiV; 2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate) UbiV [EC:1.97.1.15]"
			},
			{
				"name":"A3224_03950 protease\tK24844 ubiU; 2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate) UbiU [EC:1.97.1.15]"
			}
			]
		},
		{
			"name":"Family U62",
			"children":[
			{
				"name":"A3224_00605 TldD protein\tK03568 tldD; TldD protein"
			},
			{
				"name":"A3224_00615 TldD protein\tK03568 tldD; TldD protein"
			}
			]
		}
		]
	},
	{
		"name":"Peptidase inhibitors",
		"children":[
		{
			"name":"Family I1: Kazal family"
		},
		{
			"name":"Family I2: Kunitz - BPTI family"
		},
		{
			"name":"Family I4: serpin family"
		},
		{
			"name":"Family I11: ecotin family",
			"children":[
			{
				"name":"A3224_00355 hypothetical protein\tK08276 eco; ecotin"
			}
			]
		},
		{
			"name":"Family I17: WAP-type family"
		},
		{
			"name":"Family I25: cystatin family"
		},
		{
			"name":"Family I27: calpastatin family"
		},
		{
			"name":"Family I32: IAP family"
		},
		{
			"name":"Family I34: IA3 family"
		},
		{
			"name":"Family I35: timp family"
		},
		{
			"name":"Family I39: alpha2M family"
		},
		{
			"name":"Family I47: latexin family"
		},
		{
			"name":"Family I49: proSAAS family"
		},
		{
			"name":"Family I51: IC family"
		},
		{
			"name":"Family I57: staphostatin B family"
		},
		{
			"name":"Family I63"
		},
		{
			"name":"Family I80"
		},
		{
			"name":"Family I87",
			"children":[
			{
				"name":"A3224_01170 protease modulator HflC\tK04087 hflC; modulator of FtsH protease HflC"
			},
			{
				"name":"A3224_01165 protease modulator HflK\tK04088 hflK; modulator of FtsH protease HflK"
			}
			]
		},
		{
			"name":"Family I93"
		}
		]
	}
	]
}