{
	"name":"mwo03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"MWSIV6_0464 rnp1; Ribonuclease P protein component 1\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"MWSIV6_1063 rnp2; Ribonuclease P protein component 2\tK03537 POP5; ribonuclease P\/MRP protein subunit POP5 [EC:3.1.26.5]"
				},
				{
					"name":"MWSIV6_1064 rnp3; Ribonuclease P protein component 3\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				},
				{
					"name":"MWSIV6_0164 rnp4; Ribonuclease P protein component 4\tK03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"MWSIV6_0363 rnz; Ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"MWSIV6_0141 rtcB; RNA splicing ligase RtcB\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				},
				{
					"name":"MWSIV6_0142 Protein archease\tK24956 ZBTB8OS; protein archease"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"MWSIV6_1444 tuf; Elongation factor 1-alpha\tK03231 EEF1A; elongation factor 1-alpha"
				},
				{
					"name":"MWSIV6_1577 Gtpbp1; GTP-binding protein 1\tK03231 EEF1A; elongation factor 1-alpha"
				}
				]
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"MWSIV6_0505 gltX; Glutamate-tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"MWSIV6_0979 proS; Proline-tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"MWSIV6_1756 ileS; Isoleucine-tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"MWSIV6_0048 leuS; Leucine-tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"MWSIV6_0953 metG; Methionine-tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"MWSIV6_1825 argS; Arginine-tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"MWSIV6_0221 alaS; Alanine-tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"MWSIV6_0377 glyS; Glycine-tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"MWSIV6_1832 thrS; Threonine-tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"MWSIV6_1513 serS; Type-2 serine-tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"MWSIV6_1141 valS; Valine-tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"MWSIV6_0656 hisS; Histidine-tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"MWSIV6_1116 pheS; Phenylalanine-tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"MWSIV6_1144 pheT; Phenylalanine-tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"MWSIV6_0308 tyrS; Tyrosine-tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"MWSIV6_0663 trpS; Tryptophan-tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors"
			},
			{
				"name":"AARS associated factors"
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"MWSIV6_1203 putative threonylcarbamoyladenosine tRNA methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"MWSIV6_1583 trm1; tRNA (guanine(26)-N(2))-dimethyltransferase\tK00555 TRMT1; tRNA (guanine26-N2\/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]"
				},
				{
					"name":"MWSIV6_0404 trm5b; tRNA (guanine(37)-N1)-methyltransferase Trm5b\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"MWSIV6_1793 trmI; tRNA (adenine(57)-N(1)\/adenine(58)-N(1))-methyltransferase TrmI\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]"
				},
				{
					"name":"MWSIV6_1425 taw1; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase\tK15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]"
				},
				{
					"name":"MWSIV6_1593 taw2; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase\tK07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"MWSIV6_1216 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"MWSIV6_0485 truB_1; putative tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"MWSIV6_0486 truB_3; putative tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"MWSIV6_0068 truD; tRNA pseudouridine synthase D\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"MWSIV6_1711 pus10; tRNA pseudouridine synthase Pus10\tK07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors"
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex",
				"children":[
				{
					"name":"MWSIV6_1193 putative protein MJ1136\tK07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]"
				}
				]
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"MWSIV6_0229 sua5; Threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"MWSIV6_1282 putative protein\tK06963 TAN1; tRNA acetyltransferase TAN1"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors"
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"MWSIV6_0655 UPF0278 protein\tK09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"MWSIV6_0363 rnz; Ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"MWSIV6_0944 cca; CCA-adding enzyme\tK07558 K07558; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases",
				"children":[
				{
					"name":"MWSIV6_0662 endA; tRNA-splicing endonuclease\tK01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]"
				}
				]
			},
			{
				"name":"tRNA splicing ligases",
				"children":[
				{
					"name":"MWSIV6_0141 rtcB; RNA splicing ligase RtcB\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"MWSIV6_0943 RNA 2',3'-cyclic phosphodiesterase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"MWSIV6_0048 leuS; Leucine-tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"MWSIV6_0082 lysS; Lysine-tRNA ligase\tK04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]"
				},
				{
					"name":"MWSIV6_0979 proS; Proline-tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"MWSIV6_0308 tyrS; Tyrosine-tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"MWSIV6_0663 trpS; Tryptophan-tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"MWSIV6_1832 thrS; Threonine-tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"MWSIV6_1756 ileS; Isoleucine-tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"MWSIV6_0221 alaS; Alanine-tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"MWSIV6_1141 valS; Valine-tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"MWSIV6_0953 metG; Methionine-tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"MWSIV6_1513 serS; Type-2 serine-tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"MWSIV6_0505 gltX; Glutamate-tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"MWSIV6_1825 argS; Arginine-tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"MWSIV6_1116 pheS; Phenylalanine-tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"MWSIV6_1144 pheT; Phenylalanine-tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"MWSIV6_0656 hisS; Histidine-tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"MWSIV6_0638 aspS; Aspartate-tRNA(Asp\/Asn) ligase\tK09759 aspC; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]"
				},
				{
					"name":"MWSIV6_0042 sepS; O-phosphoserine-tRNA(Cys) ligase\tK07587 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]"
				},
				{
					"name":"MWSIV6_1453 O-phospho-L-seryl-tRNA:Cys-tRNA synthase\tK06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]"
				}
				]
			},
			{
				"name":"Trans-editing factors"
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"MWSIV6_1203 putative threonylcarbamoyladenosine tRNA methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"MWSIV6_0380 putative tRNA\/rRNA methyltransferase MJ1476\tK02533 lasT; tRNA\/rRNA methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"MWSIV6_1099 trmG10; tRNA (guanine(10)-N2)-dimethyltransferase\tK07446 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213]"
				},
				{
					"name":"MWSIV6_1505 tRNA (cytidine(56)-2'-O)-methyltransferase\tK07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"MWSIV6_1216 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"MWSIV6_0485 truB_1; putative tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"MWSIV6_0486 truB_3; putative tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"MWSIV6_0068 truD; tRNA pseudouridine synthase D\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors"
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"MWSIV6_1803 putative bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein\tK15904 kae1-bud32; bifunctional N6-L-threonylcarbamoyladenine synthase \/ protein kinase Bud32 [EC:2.3.1.234 2.7.11.1]"
				},
				{
					"name":"MWSIV6_1097 putative protein\tK09119 cgi121; KEOPS complex subunit Cgi121"
				},
				{
					"name":"MWSIV6_1054 putative protein\tK09741 pcc1; KEOPS complex subunit Pcc1"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"MWSIV6_1500 queC; 7-cyano-7-deazaguanine synthase\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"MWSIV6_1620 queD; putative 6-carboxy-5,6,7,8-tetrahydropterin synthase\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"MWSIV6_1619 queE; 7-carboxy-7-deazaguanine synthase\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"MWSIV6_0592 tgtA; tRNA-guanine(15) transglycosylase\tK18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]"
				},
				{
					"name":"MWSIV6_0223 thiI; tRNA sulfurtransferase\tK03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]"
				},
				{
					"name":"MWSIV6_1356 tiaS; tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS\tK06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]"
				},
				{
					"name":"MWSIV6_0229 sua5; Threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors"
		}
		]
	}
	]
}