{
	"name":"mxa01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases",
				"children":[
				{
					"name":"MXAN_1698 putative aminoglycoside-3'-adenylyltransferase\tK00984 aadA; streptomycin 3\\\"-adenylyltransferase [EC:2.7.7.47]"
				}
				]
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"MXAN_2193 putative membrane protein\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				},
				{
					"name":"MXAN_5267 transporter, major facilitator family\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"MXAN_3236 phosphotransferase enzyme family protein\tK06979 mph; macrolide phosphotransferase"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"MXAN_2566 drug resistance transporter, Bcr\/CflA family protein\tK18552 cmlA; MFS transporter, DHA1 family, chloramphenicol\/florfenicol resistance protein"
				}
				]
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"MXAN_0189 hypothetical protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"MXAN_4243 hypothetical protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"MXAN_0190 conserved hypothetical protein\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"MXAN_4242 putative transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"MXAN_7319 putative transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"MXAN_3402 D-alanyl-D-alanine carboxypeptidase family protein\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"MXAN_6416 ddpX; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"MXAN_0527 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_0666 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_2968 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_3904 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_3922 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_5031 efflux transporter, HAE1 family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_6178 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_7239 efflux transporter, HAE1 family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_0528 efflux transporter, AcrB\/AcrD\/AcrF family, inner membrane component\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MXAN_0667 efflux transporter, AcrB\/AcrD\/AcrF family, inner membrane component\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MXAN_2967 RND transporter, hydrophobe\/amphiphile efflux-1 (HAE1) family\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MXAN_3903 efflux transporter, AcrB\/AcrD\/AcrF family, inner membrane component\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MXAN_3923 RND transporter, hydrophobe\/amphiphile efflux-1 (HAE1) family, permease protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MXAN_5032 efflux transporter, HAE1 family, inner membrane component\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MXAN_6177 efflux transporter, AcrB\/AcrD\/AcrF family, inner membrane component\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MXAN_7240 efflux transporter, HAE1 family, inner membrane component\tK18138 acrB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]",
				"children":[
				{
					"name":"MXAN_0091 efflux transporter, HAE1 family, MFP subunit\tK18145 adeA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MXAN_0092 efflux transporter, HAE1 family, inner membrane component\tK18146 adeB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"MXAN_3744 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_3905 efflux transporter, outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_4176 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_4198 putative outer membrane macrolide efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_5030 efflux transporter, HAE1 family, outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_6176 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_6487 outer membrane efflux protein domain protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_7238 efflux transporter, HAE1 family, outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"MXAN_3744 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_3905 efflux transporter, outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_4176 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_4198 putative outer membrane macrolide efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_5030 efflux transporter, HAE1 family, outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_6176 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_6487 outer membrane efflux protein domain protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MXAN_7238 efflux transporter, HAE1 family, outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}