{
	"name":"nfn03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)"
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex"
			},
			{
				"name":"Other initiation factors"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex"
			},
			{
				"name":"DNA polymerase epsilon complex"
			},
			{
				"name":"DNA polymerase delta complex"
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)"
			},
			{
				"name":"RFC (replication factor C)"
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"NFRAN_2324 rnhA; 14.7 kDa ribonuclease H-like protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"NFRAN_0886 pcn; DNA polymerase sliding clamp\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"NFRAN_1703 fen; Flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"NFRAN_0695 lig; DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"NFRAN_2692 nop; Ribosome biogenesis protein Nop10\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex"
				}
				]
			},
			{
				"name":"ELG1-RFC complex"
			},
			{
				"name":"MRN complex"
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"NFRAN_1753 Excinuclease ABC subunit C\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"NFRAN_0095 DNA topoisomerase IB\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"NFRAN_2973 dnaG; DNA primase DnaG\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)",
				"children":[
				{
					"name":"NFRAN_1687 cdc; ORC1-type DNA replication protein\tK10725 cdc6A; archaeal cell division control protein 6"
				},
				{
					"name":"NFRAN_1468 MCM2\/3\/5 family protein\tK10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3]"
				},
				{
					"name":"NFRAN_2763 priS; DNA primase small subunit PriS\tK02683 priS; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"NFRAN_2762 priL; DNA primase large subunit PriL\tK18882 priL; DNA primase large subunit"
				},
				{
					"name":"NFRAN_1469 GINS complex protein\tK09723 ginS; DNA replication factor GINS"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"NFRAN_2324 rnhA; 14.7 kDa ribonuclease H-like protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"NFRAN_3019 rnhB; Ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases",
					"children":[
					{
						"name":"NFRAN_0007 DNA polymerase\tK02319 pol; DNA polymerase, archaea type [EC:2.7.7.7]"
					},
					{
						"name":"NFRAN_2641 polB; DNA polymerase II\tK02319 pol; DNA polymerase, archaea type [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"D-family DNA polymerases",
					"children":[
					{
						"name":"NFRAN_1693 polC; DNA polymerase II large subunit\tK02322 polC; DNA polymerase II large subunit [EC:2.7.7.7]"
					},
					{
						"name":"NFRAN_1694 polB; DNA polymerase II small subunit\tK02323 polB; DNA polymerase II small subunit [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"NFRAN_2324 rnhA; 14.7 kDa ribonuclease H-like protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"NFRAN_3019 rnhB; Ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"NFRAN_2742 Replication factor C large subunit\tK04800 rfcL; replication factor C large subunit"
					},
					{
						"name":"NFRAN_1470 rfcS; Replication factor C small subunit\tK04801 rfcS; replication factor C small subunit"
					}
					]
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"NFRAN_1703 fen; Flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"NFRAN_0695 lig; DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"NFRAN_1366 mjaIIIM; Modification methylase MjaIII\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"NFRAN_1367 DNA topoisomerase VI subunit A\tK03166 top6A; DNA topoisomerase VI subunit A [EC:5.6.2.2]"
			},
			{
				"name":"NFRAN_1368 top6B; Type 2 DNA topoisomerase 6 subunit B\tK03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]"
			},
			{
				"name":"NFRAN_0625 topA; DNA topoisomerase 1\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
			}
			]
		}
		]
	}
	]
}