{
	"name":"nge03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors"
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex"
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex"
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors"
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex",
					"children":[
					{
						"name":"Natgr_2316 DNA-directed RNA polymerase, subunit E''\tK15171 SUPT4H1; transcription elongation factor SPT4"
					},
					{
						"name":"Natgr_2217 ribosomal protein L24p\/L26e, archaeal\tK15172 SUPT5H; transcription elongation factor SPT5"
					}
					]
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex"
				},
				{
					"name":"Ran-mediated transport factors",
					"children":[
					{
						"name":"Natgr_3711 AAA family ATPase, CDC48 subfamily\tK13525 VCP; transitional endoplasmic reticulum ATPase"
					},
					{
						"name":"Natgr_3747 AAA family ATPase, CDC48 subfamily\tK13525 VCP; transitional endoplasmic reticulum ATPase"
					}
					]
				},
				{
					"name":"eIF4F and regulatory proteins"
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors",
					"children":[
					{
						"name":"Natgr_2057 putative translation factor pelota\tK06965 PELO; protein pelota"
					}
					]
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex",
					"children":[
					{
						"name":"Natgr_2004 peptide chain release factor 1\tK03265 ETF1; peptide chain release factor subunit 1"
					}
					]
				},
				{
					"name":"Protein phosphatase 2A"
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins",
					"children":[
					{
						"name":"Natgr_0889 translation elongation factor EF-1 alpha\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"Natgr_2849 GTPase\tK03231 EEF1A; elongation factor 1-alpha"
					}
					]
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule"
				},
				{
					"name":"P-body specific factors"
				},
				{
					"name":"Stress granule specific factors"
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex"
				},
				{
					"name":"Lsm complex"
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors"
				},
				{
					"name":"Exosome cofactors"
				},
				{
					"name":"TRAMP complex"
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex"
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"Natgr_2569 putative hydrolase of the metallo-beta-lactamase superfamily\tK12574 rnj; ribonuclease J [EC:3.1.-.-]"
					},
					{
						"name":"Natgr_2730 exoribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
					}
					]
				},
				{
					"name":"Helicases"
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"Natgr_2561 phosphopyruvate hydratase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"Natgr_3218 chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"Natgr_0774 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"Natgr_1734 thermosome subunit\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"Natgr_2334 thermosome subunit\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					}
					]
				},
				{
					"name":"Others"
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome"
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"Natgr_1677 DNA\/RNA helicase, superfamily II\tK03725 K03725; putative ATP-dependent RNA helicase [EC:5.6.2.-]"
					}
					]
				}
				]
			}
			]
		}
		]
	}
	]
}