{
	"name":"nte03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"NEUTE1DRAFT73917 NEUTE1DRAFT_73917; hypothetical protein\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"NEUTE1DRAFT76086 NEUTE1DRAFT_76086; hypothetical protein\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"NEUTE1DRAFT126387 NEUTE1DRAFT_126387; hypothetical protein\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"NEUTE1DRAFT60169 NEUTE1DRAFT_60169; hypothetical protein\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"NEUTE1DRAFT130633 NEUTE1DRAFT_130633; hypothetical protein\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"NEUTE1DRAFT111309 NEUTE1DRAFT_111309; hypothetical protein\tK02608 ORC6; origin recognition complex subunit 6"
				},
				{
					"name":"NEUTE1DRAFT93253 NEUTE1DRAFT_93253; hypothetical protein\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"NEUTE1DRAFT127159 NEUTE1DRAFT_127159; hypothetical protein\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"NEUTE1DRAFT79694 NEUTE1DRAFT_79694; hypothetical protein\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"NEUTE1DRAFT73454 NEUTE1DRAFT_73454; cell division control protein 54\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"NEUTE1DRAFT127687 NEUTE1DRAFT_127687; hypothetical protein\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"NEUTE1DRAFT121681 NEUTE1DRAFT_121681; hypothetical protein\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"NEUTE1DRAFT88816 NEUTE1DRAFT_88816; DNA replication licensing factor mcm7\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"NEUTE1DRAFT123527 NEUTE1DRAFT_123527; hypothetical protein\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				},
				{
					"name":"NEUTE1DRAFT88262 NEUTE1DRAFT_88262; hypothetical protein\tK02309 DBF4; regulatory subunit for Cdc7p protein kinase"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"NEUTE1DRAFT91937 NEUTE1DRAFT_91937; DNA replication complex GINS protein psf-1\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"NEUTE1DRAFT136295 NEUTE1DRAFT_136295; hypothetical protein\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"NEUTE1DRAFT88621 NEUTE1DRAFT_88621; DNA replication complex GINS protein psf-3\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"NEUTE1DRAFT115516 NEUTE1DRAFT_115516; hypothetical protein\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"NEUTE1DRAFT51953 NEUTE1DRAFT_51953; hypothetical protein\tK10731 SLD3; DNA replication regulator SLD3"
				},
				{
					"name":"NEUTE1DRAFT79505 NEUTE1DRAFT_79505; hypothetical protein\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"NEUTE1DRAFT87062 NEUTE1DRAFT_87062; hypothetical protein\tK10736 MCM10; minichromosome maintenance protein 10"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"NEUTE1DRAFT146042 NEUTE1DRAFT_146042; hypothetical protein\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"NEUTE1DRAFT77266 NEUTE1DRAFT_77266; hypothetical protein\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"NEUTE1DRAFT86342 NEUTE1DRAFT_86342; DNA primase small subunit\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"NEUTE1DRAFT58771 NEUTE1DRAFT_58771; hypothetical protein\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"NEUTE1DRAFT123761 NEUTE1DRAFT_123761; DNA polymerase epsilon\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"NEUTE1DRAFT120353 NEUTE1DRAFT_120353; hypothetical protein\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"NEUTE1DRAFT120002 NEUTE1DRAFT_120002; hypothetical protein\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"NEUTE1DRAFT76964 NEUTE1DRAFT_76964; hypothetical protein\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"NEUTE1DRAFT128869 NEUTE1DRAFT_128869; hypothetical protein\tK03504 POLD3; DNA polymerase delta subunit 3"
				},
				{
					"name":"NEUTE1DRAFT66114 NEUTE1DRAFT_66114; hypothetical protein\tK03505 POLD4; DNA polymerase delta subunit 4"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"NEUTE1DRAFT82069 NEUTE1DRAFT_82069; DNA polymerase gamma\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"NEUTE1DRAFT144541 NEUTE1DRAFT_144541; hypothetical protein\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"NEUTE1DRAFT78687 NEUTE1DRAFT_78687; hypothetical protein\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"NEUTE1DRAFT143911 NEUTE1DRAFT_143911; hypothetical protein\tK10740 RPA3; replication factor A3"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"NEUTE1DRAFT65451 NEUTE1DRAFT_65451; hypothetical protein\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"NEUTE1DRAFT144139 NEUTE1DRAFT_144139; hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"NEUTE1DRAFT73134 NEUTE1DRAFT_73134; activator 1 41 kDa subunit\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"NEUTE1DRAFT130196 NEUTE1DRAFT_130196; hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"NEUTE1DRAFT65455 NEUTE1DRAFT_65455; hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"NEUTE1DRAFT86567 NEUTE1DRAFT_86567; hypothetical protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"NEUTE1DRAFT123501 NEUTE1DRAFT_123501; hypothetical protein\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"NEUTE1DRAFT126986 NEUTE1DRAFT_126986; hypothetical protein\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"NEUTE1DRAFT131702 NEUTE1DRAFT_131702; hypothetical protein\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"NEUTE1DRAFT67522 NEUTE1DRAFT_67522; DNA-repair protein rad2\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"NEUTE1DRAFT147941 NEUTE1DRAFT_147941; hypothetical protein\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"NEUTE1DRAFT41251 NEUTE1DRAFT_41251; hypothetical protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				},
				{
					"name":"NEUTE1DRAFT129263 NEUTE1DRAFT_129263; hypothetical protein\tK26118 ATAD5; ATPase family AAA domain-containing protein 5"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"NEUTE1DRAFT132585 NEUTE1DRAFT_132585; RIP defective\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"NEUTE1DRAFT67631 NEUTE1DRAFT_67631; hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex",
					"children":[
					{
						"name":"NEUTE1DRAFT119948 NEUTE1DRAFT_119948; hypothetical protein\tK11109 POT1; protection of telomeres protein 1"
					}
					]
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins",
					"children":[
					{
						"name":"NEUTE1DRAFT72738 NEUTE1DRAFT_72738; hypothetical protein\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					},
					{
						"name":"NEUTE1DRAFT88650 NEUTE1DRAFT_88650; hypothetical protein\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					},
					{
						"name":"NEUTE1DRAFT92837 NEUTE1DRAFT_92837; hypothetical protein\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"NEUTE1DRAFT19417 NEUTE1DRAFT_19417; hypothetical protein\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"NEUTE1DRAFT127128 NEUTE1DRAFT_127128; hypothetical protein\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"NEUTE1DRAFT127587 NEUTE1DRAFT_127587; hypothetical protein\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"NEUTE1DRAFT19417 NEUTE1DRAFT_19417; hypothetical protein\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"NEUTE1DRAFT126545 NEUTE1DRAFT_126545; hypothetical protein\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"NEUTE1DRAFT76936 NEUTE1DRAFT_76936; small nuclear ribonucleoprotein Sm D2\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"NEUTE1DRAFT107812 NEUTE1DRAFT_107812; hypothetical protein\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"NEUTE1DRAFT83630 NEUTE1DRAFT_83630; hypothetical protein\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"NEUTE1DRAFT90311 NEUTE1DRAFT_90311; hypothetical protein\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"NEUTE1DRAFT144139 NEUTE1DRAFT_144139; hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"NEUTE1DRAFT73134 NEUTE1DRAFT_73134; activator 1 41 kDa subunit\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"NEUTE1DRAFT130196 NEUTE1DRAFT_130196; hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"NEUTE1DRAFT65455 NEUTE1DRAFT_65455; hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"NEUTE1DRAFT146938 NEUTE1DRAFT_146938; DNA repair protein rad32\tK10865 MRE11; double-strand break repair protein MRE11"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"NEUTE1DRAFT63387 NEUTE1DRAFT_63387; hypothetical protein\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"NEUTE1DRAFT93386 NEUTE1DRAFT_93386; hypothetical protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"NEUTE1DRAFT125187 NEUTE1DRAFT_125187; hypothetical protein\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"NEUTE1DRAFT69987 NEUTE1DRAFT_69987; hypothetical protein\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
				},
				{
					"name":"NEUTE1DRAFT73486 NEUTE1DRAFT_73486; hypothetical protein\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"NEUTE1DRAFT150529 NEUTE1DRAFT_150529; hypothetical protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"NEUTE1DRAFT99147 NEUTE1DRAFT_99147; hypothetical protein\tK23314 WRAP53; telomerase Cajal body protein 1"
				},
				{
					"name":"NEUTE1DRAFT123138 NEUTE1DRAFT_123138; hypothetical protein\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"NEUTE1DRAFT130751 NEUTE1DRAFT_130751; hypothetical protein\tK22485 TBF1; protein TBF1"
				},
				{
					"name":"NEUTE1DRAFT95731 NEUTE1DRAFT_95731; hypothetical protein\tK28506 GBP2; serine\/arginine (SR)-type shuttling mRNA binding protein"
				},
				{
					"name":"NEUTE1DRAFT78640 NEUTE1DRAFT_78640; hypothetical protein\tK28514 TCG1; single-stranded TG1-3 DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"NEUTE1DRAFT72102 NEUTE1DRAFT_72102; DNA topoisomerase I\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"NEUTE1DRAFT79101 NEUTE1DRAFT_79101; DNA topoisomerase 2\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"NEUTE1DRAFT81659 NEUTE1DRAFT_81659; hypothetical protein\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)"
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"NEUTE1DRAFT86567 NEUTE1DRAFT_86567; hypothetical protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"NEUTE1DRAFT86567 NEUTE1DRAFT_86567; hypothetical protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"NEUTE1DRAFT131702 NEUTE1DRAFT_131702; hypothetical protein\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"NEUTE1DRAFT67522 NEUTE1DRAFT_67522; DNA-repair protein rad2\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"NEUTE1DRAFT41251 NEUTE1DRAFT_41251; hypothetical protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	}
	]
}