{ "name":"oha01001", "children":[ { "name":"Serine\/threonine kinases: AGC group", "children":[ { "name":"PKA family", "children":[ { "name":"104338831 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"104333609 PRKX; cAMP-dependent protein kinase catalytic subunit PRKX\tK19584 PRKX; protein kinase X [EC:2.7.11.11]" } ] }, { "name":"PKG family", "children":[ { "name":"104330398 PRKG1; cGMP-dependent protein kinase 1\tK07376 PRKG1; cGMP-dependent protein kinase 1 [EC:2.7.11.12]" } ] }, { "name":"PKC family [OT]", "children":[ { "name":"104332942 PRKCA; protein kinase C alpha type\tK02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]" }, { "name":"104336128 protein kinase C beta type-like\tK19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]" }, { "name":"104336617 PRKCD; protein kinase C delta type isoform X1\tK06068 PRKCD; novel protein kinase C delta type [EC:2.7.11.13]" }, { "name":"104333589 PRKCE; protein kinase C epsilon type\tK18050 PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]" }, { "name":"104335020 PRKCH; protein kinase C eta type\tK18051 PRKCH; novel protein kinase C eta type [EC:2.7.11.13]" }, { "name":"104336811 PRKCQ; protein kinase C theta type\tK18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]" }, { "name":"104329331 PRKCZ; protein kinase C zeta type isoform X1\tK18952 PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]" }, { "name":"104334402 PRKCI; protein kinase C iota type\tK06069 PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]" } ] }, { "name":"PKN family", "children":[ { "name":"104338844 PKN2; serine\/threonine-protein kinase N2\tK23691 PKN2; serine\/threonine-protein kinase N2 [EC:2.7.11.13]" }, { "name":"104329933 PKN3; serine\/threonine-protein kinase N3\tK23692 PKN3; serine\/threonine-protein kinase N3 [EC:2.7.11.13]" } ] }, { "name":"AUR family [OT]", "children":[ { "name":"104328787 AURKA; LOW QUALITY PROTEIN: aurora kinase A\tK11481 AURKA; aurora kinase A [EC:2.7.11.1]" } ] }, { "name":"PDK1 family", "children":[ { "name":"104336152 PDPK1; 3-phosphoinositide-dependent protein kinase 1\tK06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]" } ] }, { "name":"AKT\/PKB family", "children":[ { "name":"104335294 AKT1; RAC-alpha serine\/threonine-protein kinase\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"104336332 AKT3; RAC-gamma serine\/threonine-protein kinase isoform X1\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"104336356 AKT2; RAC-beta serine\/threonine-protein kinase isoform X1\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" } ] }, { "name":"SGK family [OT]", "children":[ { "name":"104327068 SGK1; LOW QUALITY PROTEIN: serine\/threonine-protein kinase Sgk1\tK13302 SGK1; serum\/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]" }, { "name":"104336860 SGK2; serine\/threonine-protein kinase Sgk2\tK13303 SGK2; serum\/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]" }, { "name":"104334830 serine\/threonine-protein kinase Sgk3\tK13304 SGK3; serum\/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]" } ] }, { "name":"RSK family [OT]", "children":[ { "name":"104331868 RPS6KA6; ribosomal protein S6 kinase alpha-6\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"104334983 RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"104337571 RPS6KA1; ribosomal protein S6 kinase alpha-1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"104338111 RPS6KA2; ribosomal protein S6 kinase alpha-2\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"104331483 RPS6KA5; ribosomal protein S6 kinase alpha-5\tK04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]" }, { "name":"104339631 RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]" }, { "name":"104327870 RPS6KC1; ribosomal protein S6 kinase delta-1 isoform X1\tK20839 RSKL; ribosomal protein S6 kinase-like" }, { "name":"104334079 RPS6KL1; ribosomal protein S6 kinase-like 1\tK20839 RSKL; ribosomal protein S6 kinase-like" } ] }, { "name":"NDR family", "children":[ { "name":"104328093 STK38; serine\/threonine-protein kinase 38\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]" }, { "name":"104335258 STK38L; serine\/threonine-protein kinase 38-like\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]" }, { "name":"104328693 LATS1; serine\/threonine-protein kinase LATS1\tK08791 LATS1_2; serine\/threonine-protein kinase LATS1\/2 [EC:2.7.11.1]" }, { "name":"104337294 LATS2; serine\/threonine-protein kinase LATS2\tK08791 LATS1_2; serine\/threonine-protein kinase LATS1\/2 [EC:2.7.11.1]" } ] }, { "name":"MAST family [OT]", "children":[ { "name":"104330999 MAST4; microtubule-associated serine\/threonine-protein kinase 4\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"104339462 MAST3; microtubule-associated serine\/threonine-protein kinase 3\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"104339505 MAST2; microtubule-associated serine\/threonine-protein kinase 2\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"104339033 MASTL; serine\/threonine-protein kinase greatwall\tK16309 MASTL; serine\/threonine-protein kinase greatwall [EC:2.7.11.36]" } ] }, { "name":"YANK family", "children":[ { "name":"104326833 STK32C; serine\/threonine-protein kinase 32C\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" }, { "name":"104327502 STK32A; serine\/threonine-protein kinase 32A\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" }, { "name":"104331092 STK32B; serine\/threonine-protein kinase 32B\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" } ] }, { "name":"DMPK family [OT]", "children":[ { "name":"104326616 ROCK1; rho-associated protein kinase 1\tK04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.39]" }, { "name":"104332046 ROCK2; rho-associated protein kinase 2\tK17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.39]" }, { "name":"104331523 CDC42BPB; serine\/threonine-protein kinase MRCK beta\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"104331956 CDC42BPA; serine\/threonine-protein kinase MRCK alpha isoform X1\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"104331426 CIT; citron Rho-interacting kinase isoform X1\tK16308 CIT; citron Rho-interacting kinase [EC:2.7.11.35]" } ] }, { "name":"GRK family [OT]", "children":[ { "name":"104327200 GRK7; LOW QUALITY PROTEIN: G protein-coupled receptor kinase 7\tK00909 GRK1_7; rhodopsin kinase [EC:2.7.11.14]" }, { "name":"104328558 beta-adrenergic receptor kinase 2\tK00910 ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]" }, { "name":"104326337 GRK6; G protein-coupled receptor kinase 6\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" }, { "name":"104332356 GRK5; G protein-coupled receptor kinase 5\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" }, { "name":"104335200 GRK4; G protein-coupled receptor kinase 4\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" } ] }, { "name":"Other" } ] }, { "name":"Serine\/threonine kinases: CAMK group", "children":[ { "name":"CAMK1 family [OT]", "children":[ { "name":"104333151 CAMK1G; calcium\/calmodulin-dependent protein kinase type 1G\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"104337652 CAMK1D; calcium\/calmodulin-dependent protein kinase type 1D\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"104332557 LOW QUALITY PROTEIN: calcium\/calmodulin-dependent protein kinase type IV-like\tK05869 CAMK4; calcium\/calmodulin-dependent protein kinase IV [EC:2.7.11.17]" }, { "name":"104337839 CAMK4; calcium\/calmodulin-dependent protein kinase type IV\tK05869 CAMK4; calcium\/calmodulin-dependent protein kinase IV [EC:2.7.11.17]" } ] }, { "name":"CAMK2 family", "children":[ { "name":"104326897 CAMK2A; calcium\/calmodulin-dependent protein kinase type II subunit alpha\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"104335803 CAMK2G; calcium\/calmodulin-dependent protein kinase type II subunit gamma\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"104336719 CAMK2D; calcium\/calmodulin-dependent protein kinase type II subunit delta\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" } ] }, { "name":"CAMKL family", "children":[ { "name":"104338183 BRSK2; serine\/threonine-protein kinase BRSK2\tK08796 BRSK; BR serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"104328340 HUNK; hormonally up-regulated neu tumor-associated kinase\tK08797 HUNK; hormonally upregulated Neu-associated kinase [EC:2.7.11.1]" }, { "name":"104327859 MARK1; serine\/threonine-protein kinase MARK1\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"104331528 MARK3; MAP\/microtubule affinity-regulating kinase 3 isoform X1\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"104331736 MELK; LOW QUALITY PROTEIN: maternal embryonic leucine zipper kinase\tK08799 MELK; maternal embryonic leucine zipper kinase [EC:2.7.11.1]" }, { "name":"104337694 NIM1K; serine\/threonine-protein kinase NIM1\tK16310 NIM1; serine\/threonine-protein kinase NIM1 [EC:2.7.11.1]" }, { "name":"104338006 NUAK1; NUAK family SNF1-like kinase 1\tK08800 NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]" }, { "name":"104338929 NUAK2; NUAK family SNF1-like kinase 2\tK08800 NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]" }, { "name":"104336890 PASK; PAS domain-containing serine\/threonine-protein kinase\tK08801 PASK; PAS domain containing serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"104328031 PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]" }, { "name":"104337761 PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]" }, { "name":"104327740 SIK1; serine\/threonine-protein kinase SIK1\tK19008 SIK1; serine\/threonine-protein kinase SIK1 [EC:2.7.11.1]" }, { "name":"104336447 SIK2; serine\/threonine-protein kinase SIK2\tK16311 SIK2; serine\/threonine-protein kinase SIK2 [EC:2.7.11.1]" }, { "name":"104339459 SIK3; serine\/threonine-protein kinase SIK3\tK19009 SIK3; serine\/threonine-protein kinase SIK3 [EC:2.7.11.1]" }, { "name":"104332639 SNRK; SNF-related serine\/threonine-protein kinase\tK08802 SNRK; SNF related kinase [EC:2.7.11.1]" }, { "name":"104339572 STK11; serine\/threonine-protein kinase STK11\tK07298 STK11; serine\/threonine-protein kinase 11 [EC:2.7.11.1]" } ] }, { "name":"DAPK family", "children":[ { "name":"104330860 DAPK3; death-associated protein kinase 3\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"104331159 DAPK1; death-associated protein kinase 1 isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"104337406 DAPK2; death-associated protein kinase 2 isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"104332419 STK17B; serine\/threonine-protein kinase 17B\tK08804 STK17; serine\/threonine kinase 17 [EC:2.7.11.1]" }, { "name":"104337166 STK17A; serine\/threonine-protein kinase 17A\tK08804 STK17; serine\/threonine kinase 17 [EC:2.7.11.1]" } ] }, { "name":"DCAMKL family", "children":[ { "name":"104332696 DCLK1; serine\/threonine-protein kinase DCLK1 isoform X1\tK08805 DCLK1_2; doublecortin-like kinase 1\/2 [EC:2.7.11.1]" }, { "name":"104337020 DCLK2; serine\/threonine-protein kinase DCLK2\tK08805 DCLK1_2; doublecortin-like kinase 1\/2 [EC:2.7.11.1]" }, { "name":"104328641 DCLK3; serine\/threonine-protein kinase DCLK3\tK17530 DCLK3; doublecortin-like kinase 3 [EC:2.7.11.1]" } ] }, { "name":"MAPKAPK family [OT]", "children":[ { "name":"104334109 MAPKAPK3; MAP kinase-activated protein kinase 3\tK04444 MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]" }, { "name":"104335306 MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1\tK04442 MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]" }, { "name":"104339510 MKNK1; MAP kinase-interacting serine\/threonine-protein kinase 1\tK04372 MKNK; MAP kinase interacting serine\/threonine kinase [EC:2.7.11.1]" } ] }, { "name":"MLCK family", "children":[ { "name":"104331215 MYLK4; myosin light chain kinase family member 4\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"104335392 MYLK3; myosin light chain kinase 3\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"104336300 myosin light chain kinase, smooth muscle\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"104329015 TTN; LOW QUALITY PROTEIN: titin\tK12567 TTN; titin [EC:2.7.11.1]" } ] }, { "name":"PHK family", "children":[ { "name":"104329392 PHKG1; LOW QUALITY PROTEIN: phosphorylase b kinase gamma catalytic chain, skeletal muscle\/heart isoform\tK00871 PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]" } ] }, { "name":"PIM family [OT]" }, { "name":"PKD family", "children":[ { "name":"104329288 PRKD3; serine\/threonine-protein kinase D3\tK06070 PKD; protein kinase D [EC:2.7.11.13]" }, { "name":"104338135 PRKD1; serine\/threonine-protein kinase D1 isoform X1\tK06070 PKD; protein kinase D [EC:2.7.11.13]" } ] }, { "name":"PSK family", "children":[ { "name":"104328582 PSKH1; serine\/threonine-protein kinase H1\tK08808 PSKH; protein serine kinase H [EC:2.7.11.1]" } ] }, { "name":"RAD53 family", "children":[ { "name":"104327946 CHEK2; serine\/threonine-protein kinase Chk2\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]" } ] }, { "name":"Trio family [OT]", "children":[ { "name":"104333089 TRIO; LOW QUALITY PROTEIN: triple functional domain protein\tK08810 TRIO; triple functional domain protein [EC:2.7.11.1]" }, { "name":"104336302 KALRN; kalirin\tK15048 KALRN; kalirin [EC:2.7.11.1]" }, { "name":"104326255 OBSCN; obscurin\tK17531 OBSCN; obscurin-RhoGEF [EC:2.7.11.1]" } ] }, { "name":"TSSK family", "children":[ { "name":"104326496 TSSK3; testis-specific serine\/threonine-protein kinase 3\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"104335039 TSSK2; testis-specific serine\/threonine-protein kinase 2\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"104337110 testis-specific serine\/threonine-protein kinase 6-like\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" } ] }, { "name":"CDPK family" }, { "name":"CASK family", "children":[ { "name":"104327684 CASK; peripheral plasma membrane protein CASK isoform X1\tK06103 CASK; calcium\/calmodulin-dependent serine protein kinase [EC:2.7.11.1]" } ] }, { "name":"Trbl family", "children":[ { "name":"104330490 TRIB1; tribbles homolog 1\tK08814 TRIB1_2; tribbles homolog 1\/2" }, { "name":"104332034 TRIB2; tribbles homolog 2\tK08814 TRIB1_2; tribbles homolog 1\/2" } ] }, { "name":"Other", "children":[ { "name":"104326410 STK40; serine\/threonine-protein kinase 40 isoform X1\tK16312 STK40; serine\/threonine-protein kinase 40 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CK1 group", "children":[ { "name":"CK1 family [OT]", "children":[ { "name":"104330552 CSNK1A1; casein kinase I isoform alpha isoform X1\tK08957 CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]" }, { "name":"104330374 casein kinase I isoform gamma-3-like\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"104330611 CSNK1G1; casein kinase I isoform gamma-1 isoform X1\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"104331309 CSNK1G3; casein kinase I isoform gamma-3 isoform X1\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"104327621 CSNK1D; casein kinase I isoform delta isoform X1\tK08959 CSNK1D; casein kinase 1, delta [EC:2.7.11.1]" }, { "name":"104332380 CSNK1E; casein kinase I isoform epsilon\tK08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]" } ] }, { "name":"TTBK family", "children":[ { "name":"104328125 TTBK2; LOW QUALITY PROTEIN: tau-tubulin kinase 2\tK08815 TTBK; tau tubulin kinase [EC:2.7.11.26]" }, { "name":"104334349 TTBK1; tau-tubulin kinase 1\tK08815 TTBK; tau tubulin kinase [EC:2.7.11.26]" } ] }, { "name":"VRK family", "children":[ { "name":"104331510 VRK1; serine\/threonine-protein kinase VRK1 isoform X1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" }, { "name":"104333675 VRK3; inactive serine\/threonine-protein kinase VRK3\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" }, { "name":"104336680 VRK2; serine\/threonine-protein kinase VRK2\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CMGC group", "children":[ { "name":"CDK family", "children":[ { "name":"104329338 cyclin-dependent kinase 11B isoform X1\tK08818 CDC2L; cell division cycle 2-like [EC:2.7.11.22]" }, { "name":"104329931 CDK1; cyclin-dependent kinase 1 isoform X1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]" }, { "name":"104337260 CDK3; cyclin-dependent kinase 3\tK02088 CDK3; cyclin-dependent kinase 3 [EC:2.7.11.22]" }, { "name":"104330889 CDK6; cyclin-dependent kinase 6\tK02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]" }, { "name":"104331041 CDK7; cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]" }, { "name":"104332689 CDK19; LOW QUALITY PROTEIN: cyclin-dependent kinase 19\tK02208 CDK8_11; cyclin-dependent kinase 8\/11 [EC:2.7.11.22 2.7.11.23]" }, { "name":"104337328 CDK8; cyclin-dependent kinase 8\tK02208 CDK8_11; cyclin-dependent kinase 8\/11 [EC:2.7.11.22 2.7.11.23]" }, { "name":"104330069 CDK9; cyclin-dependent kinase 9\tK02211 CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]" }, { "name":"104332014 CDK12; LOW QUALITY PROTEIN: cyclin-dependent kinase 12\tK08819 CDK12_13; cyclin-dependent kinase 12\/13 [EC:2.7.11.22 2.7.11.23]" }, { "name":"104337171 CDK13; cyclin-dependent kinase 13\tK08819 CDK12_13; cyclin-dependent kinase 12\/13 [EC:2.7.11.22 2.7.11.23]" }, { "name":"104330898 CDK14; cyclin-dependent kinase 14 isoform X1\tK08821 CDK14; cyclin-dependent kinase 14 [EC:2.7.11.22]" }, { "name":"104334233 CDK15; LOW QUALITY PROTEIN: cyclin-dependent kinase 15\tK15594 CDK15; cyclin-dependent kinase 15 [EC:2.7.11.22]" }, { "name":"104334480 CDK17; cyclin-dependent kinase 17 isoform X1\tK15595 CDK17; cyclin-dependent kinase 17 [EC:2.7.11.22]" }, { "name":"104338915 CDK18; cyclin-dependent kinase 18\tK15596 CDK18; cyclin-dependent kinase 18 [EC:2.7.11.22]" } ] }, { "name":"MAPK family [OT]", "children":[ { "name":"104334853 MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1\tK04371 ERK; mitogen-activated protein kinase 1\/3 [EC:2.7.11.24]" }, { "name":"104334579 MAPK6; mitogen-activated protein kinase 6\tK06855 MAPK4_6; mitogen-activated protein kinase 4\/6 [EC:2.7.11.24]" }, { "name":"104335573 MAPK4; mitogen-activated protein kinase 4 isoform X1\tK06855 MAPK4_6; mitogen-activated protein kinase 4\/6 [EC:2.7.11.24]" }, { "name":"104333827 MAPK15; mitogen-activated protein kinase 15\tK19603 MAPK15; mitogen-activated protein kinase 15 [EC:2.7.11.24]" }, { "name":"104326885 MAPK9; mitogen-activated protein kinase 9 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"104331780 MAPK10; mitogen-activated protein kinase 10 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"104337811 MAPK8; mitogen-activated protein kinase 8 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"104330023 MAPK11; mitogen-activated protein kinase 11\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"104330049 MAPK12; mitogen-activated protein kinase 12\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"104336307 mitogen-activated protein kinase 13-like\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"104336312 MAPK14; mitogen-activated protein kinase 14\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"104328049 NLK; LOW QUALITY PROTEIN: serine\/threonine-protein kinase NLK\tK04468 NLK; nemo like kinase [EC:2.7.11.24]" } ] }, { "name":"GSK family [OT]", "children":[ { "name":"104336035 GSK3B; glycogen synthase kinase-3 beta\tK03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]" } ] }, { "name":"CLK family", "children":[ { "name":"104326883 CLK4; dual specificity protein kinase CLK4 isoform X1\tK23561 CLK1_4; dual specificity protein kinase CLK1\/4 [EC:2.7.12.1]" }, { "name":"104339457 CLK1; dual specificity protein kinase CLK1\tK23561 CLK1_4; dual specificity protein kinase CLK1\/4 [EC:2.7.12.1]" }, { "name":"104330629 CLK3; LOW QUALITY PROTEIN: dual specificity protein kinase CLK3\tK08823 CLK2_3; dual specificity protein kinase CLK2\/3 [EC:2.7.12.1]" }, { "name":"104336688 CLK2; dual specificity protein kinase CLK2\tK08823 CLK2_3; dual specificity protein kinase CLK2\/3 [EC:2.7.12.1]" } ] }, { "name":"CDKL family", "children":[ { "name":"104327782 CDKL1; cyclin-dependent kinase-like 1\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"104334977 CDKL5; cyclin-dependent kinase-like 5\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"104336722 CDKL2; cyclin-dependent kinase-like 2 isoform X1\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" } ] }, { "name":"DYRK family [OT]", "children":[ { "name":"104327764 DYRK1A; dual specificity tyrosine-phosphorylation-regulated kinase 1A\tK08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]" }, { "name":"104326771 DYRK2; dual specificity tyrosine-phosphorylation-regulated kinase 2\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"104328929 DYRK3; dual specificity tyrosine-phosphorylation-regulated kinase 3\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"104333005 DYRK4; dual specificity tyrosine-phosphorylation-regulated kinase 4\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"104327904 HIPK4; homeodomain-interacting protein kinase 4\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"104331808 HIPK3; homeodomain-interacting protein kinase 3\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"104333524 HIPK1; homeodomain-interacting protein kinase 1\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"104338301 HIPK2; LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 2\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"104327420 PRPF4B; serine\/threonine-protein kinase PRP4 homolog\tK08827 PRPF4B; serine\/threonine-protein kinase PRP4 [EC:2.7.11.1]" } ] }, { "name":"RCK family [OT]", "children":[ { "name":"104336487 ICK; serine\/threonine-protein kinase ICK\tK08828 ICK; intestinal cell (MAK-like) kinase [EC:2.7.11.22]" }, { "name":"104326682 MAK; serine\/threonine-protein kinase MAK isoform X1\tK08829 MAK; male germ cell-associated kinase [EC:2.7.11.22]" } ] }, { "name":"SRPK family [OT]", "children":[ { "name":"104336311 SRPK1; SRSF protein kinase 1\tK15409 SRPK1; serine\/threonine-protein kinase SRPK1 [EC:2.7.11.1]" }, { "name":"104328749 SRPK2; SRSF protein kinase 2\tK08831 SRPK2; serine\/threonine-protein kinase SRPK2 [EC:2.7.11.1]" }, { "name":"104329995 SRSF protein kinase 3-like\tK08832 SRPK3; serine\/threonine-protein kinase SRPK3 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: STE group", "children":[ { "name":"STE7 family", "children":[ { "name":"104339270 MAP2K1; dual specificity mitogen-activated protein kinase kinase 1\tK04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]" }, { "name":"104330857 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2\tK04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]" }, { "name":"104335669 MAP2K3; dual specificity mitogen-activated protein kinase kinase 3\tK04432 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]" }, { "name":"104332595 MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4\tK04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]" }, { "name":"104330707 MAP2K5; dual specificity mitogen-activated protein kinase kinase 5\tK04463 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]" }, { "name":"104335932 MAP2K6; dual specificity mitogen-activated protein kinase kinase 6\tK04433 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]" } ] }, { "name":"STE20 family", "children":[ { "name":"104339480 MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1\tK04406 MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]" }, { "name":"104329443 MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4\tK04407 MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]" }, { "name":"104329581 NRK; nik-related protein kinase\tK04407 MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]" }, { "name":"104327776 MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5\tK08833 MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5 [EC:2.7.11.1]" }, { "name":"104334456 TNIK; TRAF2 and NCK-interacting protein kinase\tK08840 TNIK; TRAF2 and NCK interacting kinase [EC:2.7.11.1]" }, { "name":"104329040 myosin-IIIb\tK08834 MYO3; myosin III [EC:2.7.11.1]" }, { "name":"104339292 MYO3A; myosin-IIIa\tK08834 MYO3; myosin III [EC:2.7.11.1]" }, { "name":"104329049 STK39; STE20\/SPS1-related proline-alanine-rich protein kinase\tK08835 OXSR1; serine\/threonine-protein kinase OSR1\/STK39 [EC:2.7.11.1]" }, { "name":"104337210 OXSR1; serine\/threonine-protein kinase OSR1\tK08835 OXSR1; serine\/threonine-protein kinase OSR1\/STK39 [EC:2.7.11.1]" }, { "name":"104326264 PAK1; serine\/threonine-protein kinase PAK 1 isoform X1\tK04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]" }, { "name":"104335067 PAK2; serine\/threonine-protein kinase PAK 2 isoform X1\tK04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]" }, { "name":"104339087 PAK3; serine\/threonine-protein kinase PAK 3 isoform X1\tK05733 PAK3; p21-activated kinase 3 [EC:2.7.11.1]" }, { "name":"104330718 PAK7; serine\/threonine-protein kinase PAK 7\tK05736 PAK5; p21-activated kinase 5 [EC:2.7.11.1]" }, { "name":"104326701 PAK6; serine\/threonine-protein kinase PAK 6 isoform X1\tK05735 PAK6; p21-activated kinase 6 [EC:2.7.11.1]" }, { "name":"104336477 SLK; STE20-like serine\/threonine-protein kinase\tK08836 SLK; STE20-like kinase [EC:2.7.11.1]" }, { "name":"104332211 STK10; LOW QUALITY PROTEIN: serine\/threonine-protein kinase 10\tK08837 STK10; serine\/threonine kinase 10 [EC:2.7.11.1]" }, { "name":"104338685 STRADA; STE20-related kinase adapter protein alpha\tK08271 STRADA; STE20-related kinase adapter protein alpha" }, { "name":"104334217 STRADB; STE20-related kinase adapter protein beta\tK17532 STRADB; STE20-related kinase adapter protein beta" }, { "name":"104332133 STK3; serine\/threonine-protein kinase 3\tK04412 STK3; serine\/threonine kinase 3" }, { "name":"104328821 STK4; serine\/threonine-protein kinase 4\tK04411 STK4; serine\/threonine kinase 4" }, { "name":"104335702 STK26; serine\/threonine-protein kinase MST4\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"104336879 STK25; serine\/threonine-protein kinase 25\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"104338607 STK24; serine\/threonine-protein kinase 24\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"104331428 TAOK3; serine\/threonine-protein kinase TAO3 isoform X1\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" }, { "name":"104335878 TAOK1; serine\/threonine-protein kinase TAO1 isoform X1\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" } ] }, { "name":"STE11 family", "children":[ { "name":"104337710 MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1\tK04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]" }, { "name":"104335225 MAP3K2; mitogen-activated protein kinase kinase kinase 2\tK04420 MAP3K2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]" }, { "name":"104337214 mitogen-activated protein kinase kinase kinase 3-like\tK04421 MAP3K3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]" }, { "name":"104338682 MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1\tK04421 MAP3K3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]" }, { "name":"104334710 MAP3K4; mitogen-activated protein kinase kinase kinase 4\tK04428 MAP3K4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]" }, { "name":"104327076 MAP3K5; mitogen-activated protein kinase kinase kinase 5\tK04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]" }, { "name":"104334999 MAP3K15; mitogen-activated protein kinase kinase kinase 15\tK13986 MAP3K15; mitogen-activated protein kinase kinase kinase 15 [EC:2.7.11.25]" }, { "name":"104333250 MAP3K19; mitogen-activated protein kinase kinase kinase 19\tK17533 MAP3K19; mitogen-activated protein kinase kinase kinase 19 [EC:2.7.11.25]" } ] }, { "name":"Other", "children":[ { "name":"104339011 MAP3K8; mitogen-activated protein kinase kinase kinase 8\tK04415 MAP3K8; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]" }, { "name":"104333148 MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14\tK04466 MAP3K14; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]" } ] } ] }, { "name":"Serine\/threonine kinases: TKL group", "children":[ { "name":"IRAK family", "children":[ { "name":"104334374 interleukin-1 receptor-associated kinase-like 2\tK04731 IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]" }, { "name":"104337513 IRAK4; interleukin-1 receptor-associated kinase 4\tK04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]" } ] }, { "name":"LISK family [OT]", "children":[ { "name":"104331418 LIMK2; LIM domain kinase 2\tK05744 LIMK2; LIM domain kinase 2 [EC:2.7.11.1]" }, { "name":"104336837 TESK1; dual specificity testis-specific protein kinase 1\tK08841 TESK1; testis-specific kinase 1 [EC:2.7.12.1]" }, { "name":"104339496 TESK2; dual specificity testis-specific protein kinase 2\tK08842 TESK2; testis-specific kinase 2 [EC:2.7.12.1]" } ] }, { "name":"LRRK family", "children":[ { "name":"104339285 LRRK1; leucine-rich repeat serine\/threonine-protein kinase 1\tK08843 LRRK1; leucine-rich repeat kinase 1 [EC:2.7.11.1]" }, { "name":"104328736 LRRK2; leucine-rich repeat serine\/threonine-protein kinase 2\tK08844 LRRK2; leucine-rich repeat kinase 2 [EC:2.7.11.1]" } ] }, { "name":"MLK family", "children":[ { "name":"104333487 MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1\tK04427 MAP3K7; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]" }, { "name":"104334257 MAP3K9; mitogen-activated protein kinase kinase kinase 9\tK04417 MAP3K9; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]" }, { "name":"104329190 mitogen-activated protein kinase kinase kinase MLK4\tK17534 MLK4; mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]" }, { "name":"104328966 mitogen-activated protein kinase kinase kinase MLT\tK04424 ZAK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]" }, { "name":"104335080 MAP3K13; mitogen-activated protein kinase kinase kinase 13\tK04422 MAP3K13; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]" }, { "name":"104334073 LOW QUALITY PROTEIN: serine\/threonine-protein kinase TNNI3K-like\tK17535 TNNI3K; serine\/threonine-protein kinase TNNI3K [EC:2.7.11.1]" }, { "name":"104328434 ILK; integrin-linked protein kinase\tK06272 ILK; integrin-linked kinase [EC:2.7.11.1]" } ] }, { "name":"RAF family [OT]", "children":[ { "name":"104328000 BRAF; serine\/threonine-protein kinase B-raf\tK04365 BRAF; B-Raf proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"104335221 RAF1; RAF proto-oncogene serine\/threonine-protein kinase isoform X1\tK04366 RAF1; RAF proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"104328047 KSR1; kinase suppressor of Ras 1\tK14958 KSR1; kinase suppressor of Ras 1" } ] }, { "name":"RIPK family [OT]", "children":[ { "name":"104333489 RIPK1; receptor-interacting serine\/threonine-protein kinase 1\tK02861 RIPK1; receptor-interacting serine\/threonine-protein kinase 1 [EC:2.7.11.1]" }, { "name":"104335244 receptor-interacting serine\/threonine-protein kinase 2-like\tK08846 RIPK2; receptor-interacting serine\/threonine-protein kinase 2 [EC:2.7.11.1]" }, { "name":"104337551 RIPK2; receptor-interacting serine\/threonine-protein kinase 2\tK08846 RIPK2; receptor-interacting serine\/threonine-protein kinase 2 [EC:2.7.11.1]" }, { "name":"104327751 RIPK4; receptor-interacting serine\/threonine-protein kinase 4\tK08848 RIPK4; receptor-interacting serine\/threonine-protein kinase 4 [EC:2.7.11.1]" }, { "name":"104331987 ANKK1; ankyrin repeat and protein kinase domain-containing protein 1\tK16289 ANKK1; ankyrin repeat and protein kinase domain-containing protein 1 [EC:2.7.11.1]" } ] }, { "name":"Other", "children":[ { "name":"104333462 MLKL; mixed lineage kinase domain-like protein\tK08849 MLKL; mixed lineage kinase domain-like [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: Other", "children":[ { "name":"RGC family [OT]", "children":[ { "name":"104338373 atrial natriuretic peptide receptor 2-like\tK12324 NPR2; atrial natriuretic peptide receptor 2 [EC:4.6.1.2]" }, { "name":"104329897 GUCY2C; heat-stable enterotoxin receptor\tK12320 GUCY2C; heat-stable enterotoxin receptor [EC:4.6.1.2]" }, { "name":"104334686 retinal guanylyl cyclase 2-like\tK12321 GUCY2D_E; guanylate cyclase 2D\/E [EC:4.6.1.2]" }, { "name":"104326270 GUCY2F; retinal guanylyl cyclase 2\tK12322 GUCY2F; guanylate cyclase 2F [EC:4.6.1.2]" } ] }, { "name":"BUB family", "children":[ { "name":"104326521 BUB1; mitotic checkpoint serine\/threonine-protein kinase BUB1\tK02178 BUB1; checkpoint serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"104326702 BUB1B; LOW QUALITY PROTEIN: mitotic checkpoint serine\/threonine-protein kinase BUB1 beta\tK06637 BUB1B; mitotic checkpoint serine\/threonine-protein kinase BUB1 beta [EC:2.7.11.1]" } ] }, { "name":"Bud32 family", "children":[ { "name":"104328834 TP53RK; TP53-regulating kinase\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]" } ] }, { "name":"CAMKK family", "children":[ { "name":"104328714 CAMKK1; calcium\/calmodulin-dependent protein kinase kinase 1\tK00908 CAMKK1; calcium\/calmodulin-dependent protein kinase kinase 1 [EC:2.7.11.17]" }, { "name":"104339357 CAMKK2; calcium\/calmodulin-dependent protein kinase kinase 2\tK07359 CAMKK2; calcium\/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]" } ] }, { "name":"CDC7 family", "children":[ { "name":"104335434 CDC7; LOW QUALITY PROTEIN: cell division cycle 7-related protein kinase\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]" } ] }, { "name":"CK2 family", "children":[ { "name":"104333115 casein kinase II subunit alpha\tK03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]" }, { "name":"104336796 CSNK2A2; casein kinase II subunit alpha'\tK03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]" } ] }, { "name":"Haspin family" }, { "name":"IKK family [OT]", "children":[ { "name":"104330387 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha\tK04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]" }, { "name":"104333228 IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta\tK07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]" }, { "name":"104328930 IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon\tK07211 IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]" }, { "name":"104326820 TBK1; serine\/threonine-protein kinase TBK1\tK05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]" } ] }, { "name":"IRE family", "children":[ { "name":"104332954 ERN1; LOW QUALITY PROTEIN: serine\/threonine-protein kinase\/endoribonuclease IRE1\tK08852 ERN1; serine\/threonine-protein kinase\/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]" } ] }, { "name":"MOS family", "children":[ { "name":"104332297 MOS; proto-oncogene serine\/threonine-protein kinase mos\tK04367 MOS; proto-oncogene serine\/threonine-protein kinase mos [EC:2.7.11.1]" } ] }, { "name":"NAK family [OT]", "children":[ { "name":"104331288 AAK1; LOW QUALITY PROTEIN: AP2-associated protein kinase 1\tK08853 AAK; AP2-associated kinase [EC:2.7.11.1]" }, { "name":"104331884 BMP2K; BMP-2-inducible protein kinase\tK08854 BMP2K; BMP2 inducible kinase [EC:2.7.11.1]" }, { "name":"104336590 GAK; cyclin-G-associated kinase\tK08855 GAK; cyclin G-associated kinase [EC:2.7.11.1]" }, { "name":"104339148 serine\/threonine-protein kinase 16-like\tK08856 STK16; serine\/threonine kinase 16 [EC:2.7.11.1]" }, { "name":"104339162 serine\/threonine-protein kinase 16-like\tK08856 STK16; serine\/threonine kinase 16 [EC:2.7.11.1]" } ] }, { "name":"NEK family", "children":[ { "name":"104334804 NEK1; serine\/threonine-protein kinase Nek1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"104336620 NEK4; serine\/threonine-protein kinase Nek4\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"104336954 NEK5; serine\/threonine-protein kinase Nek5\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"104327880 NEK2; serine\/threonine-protein kinase Nek2\tK20872 NEK2; serine\/threonine-protein kinase Nek2 [EC:2.7.11.1]" }, { "name":"104336953 NEK3; serine\/threonine-protein kinase Nek3\tK20873 NEK3; serine\/threonine-protein kinase Nek3 [EC:2.7.11.1]" }, { "name":"104329725 NEK6; serine\/threonine-protein kinase Nek6\tK20875 NEK6; serine\/threonine-protein kinase Nek6 [EC:2.7.11.34]" }, { "name":"104329706 NEK7; serine\/threonine-protein kinase Nek7\tK20876 NEK7; serine\/threonine-protein kinase Nek7 [EC:2.7.11.34]" }, { "name":"104332789 NEK8; LOW QUALITY PROTEIN: serine\/threonine-protein kinase Nek8\tK20877 NEK8; serine\/threonine-protein kinase Nek8 [EC:2.7.11.1]" }, { "name":"104334132 NEK9; LOW QUALITY PROTEIN: serine\/threonine-protein kinase Nek9\tK20878 NEK9; serine\/threonine-protein kinase Nek9 [EC:2.7.11.38]" }, { "name":"104332650 NEK10; LOW QUALITY PROTEIN: serine\/threonine-protein kinase Nek10\tK20879 NEK10; serine\/threonine-protein kinase Nek10 [EC:2.7.11.1]" }, { "name":"104332648 NEK11; LOW QUALITY PROTEIN: serine\/threonine-protein kinase Nek11\tK20880 NEK11; serine\/threonine-protein kinase Nek11 [EC:2.7.11.1]" } ] }, { "name":"NKF1 family", "children":[ { "name":"104327271 SBK3; uncharacterized serine\/threonine-protein kinase SBK3\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" }, { "name":"104335535 SBK2; serine\/threonine-protein kinase SBK2\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" }, { "name":"104336110 SBK1; serine\/threonine-protein kinase SBK1\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" } ] }, { "name":"NKF2 family", "children":[ { "name":"104336692 PINK1; serine\/threonine-protein kinase PINK1, mitochondrial\tK05688 PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]" } ] }, { "name":"NKF3 family", "children":[ { "name":"104331623 LOW QUALITY PROTEIN: tyrosine-protein kinase SgK223\tK17537 SGK223; tyrosine-protein kinase SgK223 [EC:2.7.10.2]" }, { "name":"104335474 PEAK1; pseudopodium-enriched atypical kinase 1\tK17538 PEAK1; pseudopodium-enriched atypical kinase 1 [EC:2.7.10.2]" } ] }, { "name":"NKF4 family", "children":[ { "name":"104335871 serine\/threonine-protein kinase 35-like\tK08859 STK35; serine\/threonine kinase 35 [EC:2.7.11.1]" }, { "name":"104333607 PDIK1L; serine\/threonine-protein kinase PDIK1L\tK17539 PDIK1L; serine\/threonine-protein kinase PDIK1L [EC:2.7.11.1]" } ] }, { "name":"NKF5 family", "children":[ { "name":"104339655 TEX14; inactive serine\/threonine-protein kinase TEX14\tK17540 TEX14; inactive serine\/threonine-protein kinase TEX14" } ] }, { "name":"NRBP family", "children":[ { "name":"104327478 NRBP1; nuclear receptor-binding protein\tK08875 NRBP; nuclear receptor-binding protein" }, { "name":"104339328 NRBP2; nuclear receptor-binding protein 2\tK08875 NRBP; nuclear receptor-binding protein" } ] }, { "name":"PEK family [OT]", "children":[ { "name":"104329099 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1\tK16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]" }, { "name":"104329308 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase\tK16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]" }, { "name":"104329641 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3\tK08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]" }, { "name":"104326974 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4\tK16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]" } ] }, { "name":"PLK family [OT]", "children":[ { "name":"104339559 PLK1; LOW QUALITY PROTEIN: serine\/threonine-protein kinase PLK1\tK06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]" }, { "name":"104337713 PLK2; serine\/threonine-protein kinase PLK2\tK08861 PLK2; polo-like kinase 2 [EC:2.7.11.21]" }, { "name":"104339495 PLK3; serine\/threonine-protein kinase PLK3\tK08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]" }, { "name":"104339588 PLK4; serine\/threonine-protein kinase PLK4\tK08863 PLK4; polo-like kinase 4 [EC:2.7.11.21]" } ] }, { "name":"SCY1 family [OT]", "children":[ { "name":"104334485 SCYL2; SCY1-like protein 2\tK17541 SCYL2; SCY1-like protein 2" }, { "name":"104333715 SCYL3; LOW QUALITY PROTEIN: protein-associating with the carboxyl-terminal domain of ezrin\tK17542 SCYL3; SCY1-like protein 3" } ] }, { "name":"Slob family", "children":[ { "name":"104331361 PXK; PX domain-containing protein kinase-like protein\tK17543 PXK; PX domain-containing protein kinase-like protein" } ] }, { "name":"TBCK family", "children":[ { "name":"104339121 TBCK; TBC domain-containing protein kinase-like protein isoform X1\tK17544 TBCK; TBC domain-containing protein kinase-like protein" } ] }, { "name":"TLK family", "children":[ { "name":"104328977 TLK1; serine\/threonine-protein kinase tousled-like 1\tK08864 TLK; tousled-like kinase [EC:2.7.11.1]" }, { "name":"104338681 TLK2; LOW QUALITY PROTEIN: serine\/threonine-protein kinase tousled-like 2\tK08864 TLK; tousled-like kinase [EC:2.7.11.1]" } ] }, { "name":"TOPK family", "children":[ { "name":"104333217 PBK; lymphokine-activated killer T-cell-originated protein kinase\tK08865 PBK; PDZ-binding kinase [EC:2.7.12.2]" } ] }, { "name":"TTK family", "children":[ { "name":"104330406 TTK; dual specificity protein kinase TTK\tK08866 TTK; serine\/threonine-protein kinase TTK\/MPS1 [EC:2.7.12.1]" } ] }, { "name":"ULK family [OT]", "children":[ { "name":"104339180 STK36; serine\/threonine-protein kinase 36\tK06228 FU; fused [EC:2.7.11.1]" }, { "name":"104327591 ULK1; serine\/threonine-protein kinase ULK1\tK21357 ULK1; serine\/threonine-protein kinase ULK1 [EC:2.7.11.1]" }, { "name":"104339619 ULK2; serine\/threonine-protein kinase ULK2\tK08269 ULK2; serine\/threonine-protein kinase ULK2 [EC:2.7.11.1]" }, { "name":"104330187 LOW QUALITY PROTEIN: serine\/threonine-protein kinase ULK4-like\tK17545 ULK4; serine\/threonine-protein kinase ULK4 [EC:2.7.11.1]" } ] }, { "name":"VPS15 family", "children":[ { "name":"104332646 PIK3R4; phosphoinositide 3-kinase regulatory subunit 4\tK08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]" } ] }, { "name":"WEE family", "children":[ { "name":"104328003 WEE2; wee1-like protein kinase 2\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]" }, { "name":"104328423 WEE1; wee1-like protein kinase\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]" } ] }, { "name":"Wnk family", "children":[ { "name":"104327968 WNK2; serine\/threonine-protein kinase WNK2\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" }, { "name":"104330275 WNK1; serine\/threonine-protein kinase WNK1\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" } ] }, { "name":"ABC1 family", "children":[ { "name":"104331958 ADCK3; chaperone activity of bc1 complex-like, mitochondrial\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"104333776 ADCK1; uncharacterized aarF domain-containing protein kinase 1 isoform X1\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"104338310 ADCK2; LOW QUALITY PROTEIN: uncharacterized aarF domain-containing protein kinase 2\tK08869 ADCK; aarF domain-containing kinase" } ] }, { "name":"Alpha family [OT]", "children":[ { "name":"104328500 ALPK2; alpha-protein kinase 2\tK08868 ALPK; alpha-kinase" }, { "name":"104330635 ALPK3; LOW QUALITY PROTEIN: alpha-protein kinase 3\tK08868 ALPK; alpha-kinase" }, { "name":"104336727 ALPK1; alpha-protein kinase 1\tK08868 ALPK; alpha-kinase" }, { "name":"104333391 TRPM6; transient receptor potential cation channel subfamily M member 6\tK04981 TRPM6; transient receptor potential cation channel subfamily M member 6 [EC:2.7.11.1]" }, { "name":"104334640 TRPM7; transient receptor potential cation channel subfamily M member 7\tK04982 TRPM7; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1]" }, { "name":"104329069 EEF2K; eukaryotic elongation factor 2 kinase\tK08292 EEF2K; elongation factor 2 kinase [EC:2.7.11.20]" } ] }, { "name":"BCR family", "children":[ { "name":"104328213 BCR; breakpoint cluster region protein\tK08878 BCR1; breakpoint cluster region protein [EC:2.7.11.1]" } ] }, { "name":"BRD family [OT]", "children":[ { "name":"104329064 BRD3; bromodomain-containing protein 3\tK11721 BRD3; bromodomain-containing protein 3" }, { "name":"104329523 LOW QUALITY PROTEIN: bromodomain-containing protein 4-like\tK11722 BRD4; bromodomain-containing protein 4" }, { "name":"104335455 BRDT; bromodomain testis-specific protein\tK11724 BRDT; bromodomain testis-specific protein" } ] }, { "name":"FAST family" }, { "name":"G11 family" }, { "name":"H11 family" }, { "name":"PDHK family [OT]", "children":[ { "name":"104328970 PDK1; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial\tK12077 PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]" }, { "name":"104330911 PDK4; pyruvate dehydrogenase kinase, isozyme 4\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" }, { "name":"104334280 PDK3; pyruvate dehydrogenase kinase, isozyme 3\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" } ] }, { "name":"PIKK family [OT]", "children":[ { "name":"104333047 ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]" }, { "name":"104327180 ATR; LOW QUALITY PROTEIN: serine\/threonine-protein kinase ATR\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]" }, { "name":"104332764 MTOR; serine\/threonine-protein kinase mTOR\tK07203 MTOR; serine\/threonine-protein kinase mTOR [EC:2.7.11.1]" }, { "name":"104329161 PRKDC; LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]" }, { "name":"104333691 SMG1; LOW QUALITY PROTEIN: serine\/threonine-protein kinase SMG1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"104329082 TRRAP; transformation\/transcription domain-associated protein isoform X1\tK08874 TRRAP; transformation\/transcription domain-associated protein" } ] }, { "name":"RIO family [OT]", "children":[ { "name":"104326736 RIOK1; serine\/threonine-protein kinase RIO1\tK07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]" }, { "name":"104336224 RIOK2; serine\/threonine-protein kinase RIO2\tK07179 RIOK2; RIO kinase 2 [EC:2.7.11.1]" }, { "name":"104330679 RIOK3; serine\/threonine-protein kinase RIO3\tK08872 RIOK3; RIO kinase 3 [EC:2.7.11.1]" } ] }, { "name":"TAF1 family", "children":[ { "name":"104335718 TAF1; transcription initiation factor TFIID subunit 1\tK03125 TAF1; transcription initiation factor TFIID subunit 1 [EC:2.3.1.48 2.7.11.1]" }, { "name":"104331045 CIITA; MHC class II transactivator\tK08060 CIITA; MHC class II transactivator [EC:2.7.11.1]" } ] }, { "name":"TIF1 family [OT]", "children":[ { "name":"104338305 TRIM24; transcription intermediary factor 1-alpha\tK08881 TRIM24; tripartite motif-containing protein 24 [EC:2.3.2.27]" }, { "name":"104333534 TRIM33; E3 ubiquitin-protein ligase TRIM33\tK08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]" } ] }, { "name":"Other", "children":[ { "name":"104333775 UHMK1; serine\/threonine-protein kinase Kist\tK08877 UHMK1; serine\/threonine-protein kinase Kist [EC:2.7.11.1]" }, { "name":"104334112 VPRBP; protein VPRBP\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"104326594 STK31; serine\/threonine-protein kinase 31\tK16316 STK31; serine\/threonine-protein kinase 31 [EC:2.7.11.1]" }, { "name":"104329196 POMK; protein O-mannose kinase\tK17547 SGK196; glycoprotein-mannosyl O6-kinase [EC:2.7.1.183]" }, { "name":"104338932 DSTYK; dual serine\/threonine and tyrosine protein kinase\tK16288 DSTYK; dual serine\/threonine and tyrosine protein kinase [EC:2.7.12.1]" }, { "name":"104329538 STKLD1; serine\/threonine kinase-like domain-containing protein STKLD1\tK17546 STKLD1; serine\/threonine kinase-like domain-containing protein STKLD1" } ] }, { "name":"Bacterial family" } ] }, { "name":"Receptor serine\/threonine kinases (RSTK): TKL group", "children":[ { "name":"TGFBR1 family [OT]", "children":[ { "name":"104327299 ACVR1; activin receptor type-1\tK04675 ACVR1; activin receptor type-1 [EC:2.7.11.30]" }, { "name":"104336162 ACVR1B; activin receptor type-1B\tK13567 ACVR1B; activin receptor type-1B [EC:2.7.11.30]" }, { "name":"104327293 ACVR1C; LOW QUALITY PROTEIN: activin receptor type-1C\tK13568 ACVR1C; activin receptor type-1C [EC:2.7.11.30]" }, { "name":"104329943 BMPR1A; bone morphogenetic protein receptor type-1A\tK04673 BMPR1A; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]" }, { "name":"104331640 BMPR1B; bone morphogenetic protein receptor type-1B\tK13578 BMPR1B; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]" }, { "name":"104327179 TGFBR1; TGF-beta receptor type-1\tK04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]" } ] }, { "name":"TGFBR2 family [OT]", "children":[ { "name":"104331754 ACVR2A; activin receptor type-2A isoform X1\tK04670 ACVR2A; activin receptor type-2A [EC:2.7.11.30]" }, { "name":"104337202 ACVR2B; activin receptor type-2B\tK13596 ACVR2B; activin receptor type-2B [EC:2.7.11.30]" }, { "name":"104334220 BMPR2; bone morphogenetic protein receptor type-2\tK04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]" }, { "name":"104332631 TGFBR2; LOW QUALITY PROTEIN: TGF-beta receptor type-2\tK04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]" }, { "name":"104338219 TGF-beta receptor type-2-like\tK04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]" } ] } ] }, { "name":"Receptor tyrosine kinases (RTK)", "children":[ { "name":"EGFR family [OT]", "children":[ { "name":"104337164 EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor\tK04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]" }, { "name":"104339193 receptor tyrosine-protein kinase erbB-4\tK05085 ERBB4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]" } ] }, { "name":"INSR family [OT]", "children":[ { "name":"104336148 insulin receptor-related protein-like\tK05086 INSRR; insulin receptor-related receptor [EC:2.7.10.1]" }, { "name":"104328943 INSR; LOW QUALITY PROTEIN: insulin receptor\tK04527 INSR; insulin receptor [EC:2.7.10.1]" }, { "name":"104339317 IGF1R; insulin-like growth factor 1 receptor\tK05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]" } ] }, { "name":"PDGFR family [OT]", "children":[ { "name":"104334893 PDGFRA; platelet-derived growth factor receptor alpha\tK04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]" }, { "name":"104326896 PDGFRB; platelet-derived growth factor receptor beta\tK05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]" }, { "name":"104326895 CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor\tK05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]" }, { "name":"104334921 KIT; mast\/stem cell growth factor receptor Kit\tK05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]" }, { "name":"104332732 FLT3; receptor-type tyrosine-protein kinase FLT3\tK05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]" } ] }, { "name":"FGFR family [OT]", "children":[ { "name":"104332338 FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2\tK05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]" }, { "name":"104329660 FGFR3; fibroblast growth factor receptor 3\tK05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]" } ] }, { "name":"VEGFR family [OT]", "children":[ { "name":"104332713 FLT1; vascular endothelial growth factor receptor 1\tK05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]" }, { "name":"104338506 vascular endothelial growth factor receptor kdr-like\tK05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]" }, { "name":"104326892 FLT4; vascular endothelial growth factor receptor 3\tK05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]" }, { "name":"104334922 KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2\tK05098 KDR; kinase insert domain protein receptor [EC:2.7.10.1]" } ] }, { "name":"MET family", "children":[ { "name":"104337524 MET; hepatocyte growth factor receptor\tK05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]" } ] }, { "name":"TRK family [OT]", "children":[ { "name":"104331165 NTRK2; BDNF\/NT-3 growth factors receptor\tK04360 NTRK2; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]" }, { "name":"104332078 NTRK3; LOW QUALITY PROTEIN: NT-3 growth factor receptor\tK05101 NTRK3; neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]" } ] }, { "name":"EPH family [OT]", "children":[ { "name":"104327128 EPHA1; ephrin type-A receptor 1\tK05102 EPHA1; Eph receptor A1 [EC:2.7.10.1]" }, { "name":"104335991 EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2\tK05103 EPHA2; Eph receptor A2 [EC:2.7.10.1]" }, { "name":"104335514 EPHA3; LOW QUALITY PROTEIN: ephrin type-A receptor 3\tK05104 EPHA3; Eph receptor A3 [EC:2.7.10.1]" }, { "name":"104337993 EPHA4; ephrin type-A receptor 4\tK05105 EPHA4; Eph receptor A4 [EC:2.7.10.1]" }, { "name":"104336460 EPHA5; ephrin type-A receptor 5\tK05106 EPHA5; Eph receptor A5 [EC:2.7.10.1]" }, { "name":"104337382 EPHA6; ephrin type-A receptor 6\tK05107 EPHA6; Eph receptor A6 [EC:2.7.10.1]" }, { "name":"104328314 EPHA7; ephrin type-A receptor 7 isoform X1\tK05108 EPHA7; EphA7 [EC:2.7.10.1]" }, { "name":"104333002 EPHA8; ephrin type-A receptor 8\tK05109 EPHA8; Eph receptor A8 [EC:2.7.10.1]" }, { "name":"104334664 EPHA10; ephrin type-A receptor 10\tK08897 EPHA10; Eph receptor A10 [EC:2.7.10.1]" }, { "name":"104335112 EPHB1; LOW QUALITY PROTEIN: ephrin type-B receptor 1\tK05110 EPHB1; Eph receptor B1 [EC:2.7.10.1]" }, { "name":"104330014 LOW QUALITY PROTEIN: ephrin type-B receptor 2-like\tK05111 EPHB2; Eph receptor B2 [EC:2.7.10.1]" }, { "name":"104336008 EPHB3; ephrin type-B receptor 3\tK05112 EPHB3; Eph receptor B3 [EC:2.7.10.1]" }, { "name":"104334099 ephrin type-B receptor 5\tK05114 EPHB6; Eph receptor B6 [EC:2.7.10.1]" } ] }, { "name":"AXL family", "children":[ { "name":"104328109 TYRO3; tyrosine-protein kinase receptor TYRO3\tK05116 TYRO3; TYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]" }, { "name":"104326518 MERTK; tyrosine-protein kinase Mer\tK05117 MERTK; c-mer proto-oncogene tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"ALK family", "children":[ { "name":"104328172 LTK; LOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor\tK05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]" }, { "name":"104331983 ALK; ALK tyrosine kinase receptor\tK05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]" } ] }, { "name":"TIE family", "children":[ { "name":"104338861 TIE1; tyrosine-protein kinase receptor Tie-1\tK05120 TIE1; tyrosine kinase receptor 1 [EC:2.7.10.1]" }, { "name":"104326744 TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor\tK05121 TEK; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"ROR family", "children":[ { "name":"104327219 ROR1; LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR1\tK05122 ROR1; receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1]" }, { "name":"104326480 ROR2; tyrosine-protein kinase transmembrane receptor ROR2\tK05123 ROR2; receptor tyrosine kinase-like orphan receptor 2 [EC:2.7.10.1]" } ] }, { "name":"DDR family", "children":[ { "name":"104327445 epithelial discoidin domain-containing receptor 1-like\tK05124 DDR1; discoidin domain receptor family member 1 [EC:2.7.10.1]" }, { "name":"104333724 DDR2; discoidin domain-containing receptor 2\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]" }, { "name":"104335361 discoidin domain-containing receptor 2-like\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]" } ] }, { "name":"RET family", "children":[ { "name":"104333636 RET; proto-oncogene tyrosine-protein kinase receptor Ret\tK05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]" } ] }, { "name":"ROS family", "children":[ { "name":"104338799 ROS1; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS\tK05088 ROS1; proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1]" } ] }, { "name":"CCK family", "children":[ { "name":"104333591 PTK7; inactive tyrosine-protein kinase 7\tK05127 PTK7; PTK7 protein tyrosine kinase 7 [EC:2.7.10.1]" } ] }, { "name":"RYK family", "children":[ { "name":"104335104 RYK; tyrosine-protein kinase RYK\tK05128 RYK; RYK receptor-like tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"MUSK family", "children":[ { "name":"104338372 MUSK; muscle, skeletal receptor tyrosine-protein kinase\tK05129 MUSK; muscle, skeletal, receptor tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"LMR family [OT]", "children":[ { "name":"104329103 LMTK2; serine\/threonine-protein kinase LMTK2\tK08898 LMTK2; lemur tyrosine kinase 2 [EC:2.7.10.1]" } ] } ] }, { "name":"Non-receptor tyrosine kinases", "children":[ { "name":"ABL family", "children":[ { "name":"104329209 ABL1; LOW QUALITY PROTEIN: tyrosine-protein kinase ABL1\tK06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]" }, { "name":"104334011 ABL2; LOW QUALITY PROTEIN: Abelson tyrosine-protein kinase 2\tK08887 ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]" } ] }, { "name":"ACK family", "children":[ { "name":"104326860 LOW QUALITY PROTEIN: activated CDC42 kinase 1-like\tK08886 TNK2; activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]" } ] }, { "name":"CSK family", "children":[ { "name":"104333824 MATK; megakaryocyte-associated tyrosine-protein kinase\tK08888 MATK; megakaryocyte-associated tyrosine kinase [EC:2.7.10.2]" } ] }, { "name":"FAK family", "children":[ { "name":"104331111 PTK2; focal adhesion kinase 1 isoform X1\tK05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]" }, { "name":"104329906 PTK2B; protein-tyrosine kinase 2-beta\tK05871 PTK2B; focal adhesion kinase 2 [EC:2.7.10.2]" } ] }, { "name":"FES family", "children":[ { "name":"104336124 FER; tyrosine-protein kinase Fer\tK08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]" } ] }, { "name":"JAK family [OT]", "children":[ { "name":"104327217 JAK1; tyrosine-protein kinase JAK1\tK11217 JAK1; Janus kinase 1 [EC:2.7.10.2]" }, { "name":"104330779 JAK2; tyrosine-protein kinase JAK2\tK04447 JAK2; Janus kinase 2 [EC:2.7.10.2]" } ] }, { "name":"SRC family", "children":[ { "name":"104336470 BLK; tyrosine-protein kinase Blk\tK08890 BLK; B lymphoid tyrosine kinase [EC:2.7.10.2]" }, { "name":"104338808 FRK; tyrosine-protein kinase FRK\tK08892 FRK; fyn-related kinase [EC:2.7.10.2]" }, { "name":"104332676 FYN; tyrosine-protein kinase Fyn isoform X1\tK05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]" }, { "name":"104326489 LCK; tyrosine-protein kinase Lck\tK08893 HCK; hemopoietic cell kinase [EC:2.7.10.2]" }, { "name":"104332296 LYN; tyrosine-protein kinase Lyn isoform X1\tK05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]" }, { "name":"104339548 SRC; proto-oncogene tyrosine-protein kinase Src\tK05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]" }, { "name":"104328815 tyrosine-protein kinase Srms-like\tK08895 SRMS; tyrosine-protein kinase Srms [EC:2.7.10.2]" }, { "name":"104326619 YES1; tyrosine-protein kinase Yes\tK05705 YES1; tyrosine-protein kinase Yes [EC:2.7.10.2]" } ] }, { "name":"TEC family", "children":[ { "name":"104334988 BMX; cytoplasmic tyrosine-protein kinase BMX\tK08896 BMX; cytoplasmic tyrosine-protein kinase BMX [EC:2.7.10.2]" }, { "name":"104329560 BTK; tyrosine-protein kinase BTK\tK07370 BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]" }, { "name":"104336744 ITK; tyrosine-protein kinase ITK\/TSK\tK07363 ITK; IL2-inducible T-cell kinase [EC:2.7.10.2]" }, { "name":"104331894 TEC; tyrosine-protein kinase Tec\tK07364 TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]" }, { "name":"104331893 TXK; tyrosine-protein kinase TXK\tK08016 TXK; tyrosine-protein kinase TXK [EC:2.7.10.2]" } ] }, { "name":"SYK family", "children":[ { "name":"104331387 SYK; LOW QUALITY PROTEIN: tyrosine-protein kinase SYK\tK05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]" }, { "name":"104335639 ZAP70; tyrosine-protein kinase ZAP-70\tK07360 ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]" } ] }, { "name":"Other", "children":[ { "name":"104328381 STYK1; LOW QUALITY PROTEIN: tyrosine-protein kinase STYK1\tK17510 STYK1; tyrosine-protein kinase STYK1 [EC:2.7.10.2]" }, { "name":"104327923 PKDCC; protein kinase domain-containing protein, cytoplasmic\tK17548 PKDCC; extracellular tyrosine-protein kinase PKDCC  [EC:2.7.10.2]" }, { "name":"104331567 protein kinase domain-containing protein, cytoplasmic-like\tK17548 PKDCC; extracellular tyrosine-protein kinase PKDCC  [EC:2.7.10.2]" } ] }, { "name":"Bacterial" } ] }, { "name":"Histidine kinases", "children":[ { "name":"OmpR family" }, { "name":"NarL family" }, { "name":"Spo family [OT]" }, { "name":"CitB family [OT]" }, { "name":"LytTR family [OT]" }, { "name":"NtrC family" }, { "name":"CheA family [OT]" }, { "name":"Cell cycle family [OT]" }, { "name":"Lux family [OT]" }, { "name":"LuxR family [OT]" }, { "name":"Other" } ] } ] }