{
	"name":"oot03110",
	"children":[
	{
		"name":"Heat shock proteins",
		"children":[
		{
			"name":"HSP110",
			"children":[
			{
				"name":"143026808 Grp170; (RefSeq) hypoxia up-regulated Grp170 co-chaperone protein isoform X1\tK09486 HYOU1; hypoxia up-regulated 1"
			}
			]
		},
		{
			"name":"HSP100",
			"children":[
			{
				"name":"143024762 mitochondrial disaggregase-like isoform X1\tK03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB"
			},
			{
				"name":"143030915 ATP-dependent clpX-like chaperone, mitochondrial isoform X1\tK03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX"
			},
			{
				"name":"143032071 ATP-dependent clpX-like chaperone, mitochondrial\tK03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX"
			}
			]
		},
		{
			"name":"HSP90",
			"children":[
			{
				"name":"143038373 heat shock protein 83-like\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"143038374 heat shock protein HSP 90-alpha-like\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"143038375 heat shock protein 83-like\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"143017700 Trap1; (RefSeq) TNF receptor associated protein 1\tK09488 TRAP1; TNF receptor-associated protein 1"
			}
			]
		},
		{
			"name":"HSP70 \/ DNAK",
			"children":[
			{
				"name":"143023636 heat shock 70 kDa protein cognate 4-like\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
			},
			{
				"name":"143039573 heat shock 70 kDa protein cognate 4-like\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
			},
			{
				"name":"143041188 Hsc70-4; (RefSeq) heat shock protein 70 cognate 4\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
			},
			{
				"name":"143041813 heat shock 70 kDa protein 1-like\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
			},
			{
				"name":"143041814 heat shock 70 kDa protein 1-like isoform X1\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
			},
			{
				"name":"143041815 heat shock 70 kDa protein 1-like\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
			},
			{
				"name":"143039482 Hsc70-3; (RefSeq) heat shock protein 70 cognate 3\tK09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]"
			},
			{
				"name":"143032421 heat shock 70 kDa protein 14-like\tK28183 HSPA14; heat shock 70 kDa protein 14"
			},
			{
				"name":"143038509 Hsc70-5; (RefSeq) heat shock protein 70 cognate 5 isoform X1\tK04043 dnaK; molecular chaperone DnaK"
			}
			]
		},
		{
			"name":"HSP60 \/ Chaperonin",
			"children":[
			{
				"name":"143018290 molecular chaperone MKKS-like\tK09492 MKKS; McKusick-Kaufman syndrome protein"
			},
			{
				"name":"143038006 CCT2; (RefSeq) chaperonin containing TCP1 subunit 2\tK09494 CCT2; T-complex protein 1 subunit beta"
			},
			{
				"name":"143024599 CCT3; (RefSeq) chaperonin containing TCP1 subunit 3\tK09495 CCT3; T-complex protein 1 subunit gamma"
			},
			{
				"name":"143029915 CCT5; (RefSeq) chaperonin containing TCP1 subunit 5\tK09497 CCT5; T-complex protein 1 subunit epsilon"
			},
			{
				"name":"143038431 CCT6; (RefSeq) chaperonin containing TCP1 subunit 6\tK09498 CCT6; T-complex protein 1 subunit zeta"
			},
			{
				"name":"143020800 CCT8; (RefSeq) chaperonin containing TCP1 subunit 8\tK09500 CCT8; T-complex protein 1 subunit theta"
			},
			{
				"name":"143018622 Hsp60A; (RefSeq) heat shock protein 60A\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			}
			]
		},
		{
			"name":"HSP47"
		},
		{
			"name":"HSP40 \/ DNAJ",
			"children":[
			{
				"name":"143020731 Droj2; (RefSeq) dnaJ heat shock protein family (Hsp40) member A4-like\tK09502 DNAJA1; DnaJ homolog subfamily A member 1"
			},
			{
				"name":"143025332 dnaJ homolog subfamily A member 2-like isoform X1\tK09503 DNAJA2; DnaJ homolog subfamily A member 2"
			},
			{
				"name":"143024664 dnaJ homolog l(2)tid, mitochondrial isoform X1\tK09504 DNAJA3; DnaJ homolog subfamily A member 3"
			},
			{
				"name":"143018883 dnaJ homolog subfamily A member 1-like\tK09505 DNAJA4; DnaJ homolog subfamily A member 4"
			},
			{
				"name":"143038544 dnaJ homolog subfamily C member 21 isoform X1\tK09506 DNAJA5; DnaJ homolog subfamily A member 5"
			},
			{
				"name":"143020712 dnaJ protein homolog 1-like\tK09507 DNAJB1; DnaJ homolog subfamily B member 1"
			},
			{
				"name":"143024175 mrj; (RefSeq) dnaJ heat shock protein family (Hsp40) member B6 mrj\tK09512 DNAJB6; DnaJ homolog subfamily B member 6"
			},
			{
				"name":"143022947 shv; (RefSeq) dnaJ heat shock protein family member shriveled isoform X1\tK09517 DNAJB11; DnaJ homolog subfamily B member 11"
			},
			{
				"name":"143034416 dnaJ homolog subfamily B member 12\tK09518 DNAJB12; DnaJ homolog subfamily B member 12"
			},
			{
				"name":"143034975 uncharacterized protein F54F2.9\tK09521 DNAJC1; DnaJ homolog subfamily C member 1"
			},
			{
				"name":"143025476 dnaJ homolog subfamily C member 2\tK09522 DNAJC2; DnaJ homolog subfamily C member 2"
			},
			{
				"name":"143026767 P58IPK; (RefSeq) dnaJ homolog subfamily C member P58IPK\tK09523 DNAJC3; DnaJ homolog subfamily C member 3"
			},
			{
				"name":"143032823 dnaJ homolog subfamily C member 4-like isoform X1\tK09524 DNAJC4; DnaJ homolog subfamily C member 4"
			},
			{
				"name":"143021092 Csp; (RefSeq) cysteine string protein isoform X1\tK09525 DNAJC5; DnaJ homolog subfamily C member 5"
			},
			{
				"name":"143021888 dnaJ homolog subfamily C member 9\tK09529 DNAJC9; DnaJ homolog subfamily C member 9"
			},
			{
				"name":"143021877 dnaJ homolog subfamily C member 10-like\tK09530 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-]"
			},
			{
				"name":"143036485 jdp; (RefSeq) dnaJ domain-containing protein isoform X1\tK09532 DNAJC12; DnaJ homolog subfamily C member 12"
			},
			{
				"name":"143027162 Rme-8; (RefSeq) receptor mediated endocytosis 8 isoform X1\tK09533 DNAJC13; DnaJ homolog subfamily C member 13"
			},
			{
				"name":"143017847 l(3)80Fg; (RefSeq) dnaJ homolog subfamily C member 16 l(3)80Fg isoform X1\tK09536 DNAJC16; DnaJ homolog subfamily C member 16"
			},
			{
				"name":"143022256 dnaJ homolog subfamily C member 17-like isoform X1\tK09537 DNAJC17; DnaJ homolog subfamily C member 17"
			},
			{
				"name":"143022405 dnaJ homolog subfamily C member 17-like isoform X1\tK09537 DNAJC17; DnaJ homolog subfamily C member 17"
			},
			{
				"name":"143041443 mitochondrial import inner membrane translocase subunit TIM14\tK09539 DNAJC19; DnaJ homolog subfamily C member 19"
			},
			{
				"name":"143031845 dnaJ homolog subfamily C member 22-like\tK19370 DNAJC22; DnaJ homolog subfamily C member 22"
			},
			{
				"name":"143031847 dnaJ homolog subfamily C member 22-like\tK19370 DNAJC22; DnaJ homolog subfamily C member 22"
			},
			{
				"name":"143037856 Sec63; (RefSeq) translocation protein Sec63 isoform X1\tK09540 SEC63; translocation protein SEC63"
			},
			{
				"name":"143019611 dnaJ homolog subfamily C member 25 homolog\tK19371 DNAJC25; DnaJ homolog subfamily C member 25"
			},
			{
				"name":"143040691 dnaJ homolog subfamily C member 27-like\tK19372 DNAJC27; DnaJ homolog subfamily C member 27"
			},
			{
				"name":"143019625 dnaJ homolog subfamily C member 28\tK19373 DNAJC28; DnaJ homolog subfamily C member 28"
			},
			{
				"name":"143025559 uncharacterized protein LOC143025559\tK19374 DNAJC30; DnaJ homolog subfamily C member 30"
			}
			]
		},
		{
			"name":"HSP33"
		},
		{
			"name":"HSP24",
			"children":[
			{
				"name":"143025323 Roe1; (RefSeq) grpE protein homolog, mitochondrial Roe1\tK03687 GRPE; molecular chaperone GrpE"
			}
			]
		},
		{
			"name":"HSP20",
			"children":[
			{
				"name":"143027842 uncharacterized protein LOC143027842\tK09542 CRYAB; crystallin, alpha B"
			},
			{
				"name":"143035870 alpha-crystallin A chain-like\tK09542 CRYAB; crystallin, alpha B"
			}
			]
		},
		{
			"name":"HSP15"
		},
		{
			"name":"HSP10",
			"children":[
			{
				"name":"143018625 10 kDa heat shock protein, mitochondrial-like\tK04078 groES; chaperonin GroES"
			}
			]
		},
		{
			"name":"GimC",
			"children":[
			{
				"name":"143019870 Pfdn1; (RefSeq) prefoldin subunit 1\tK09548 PFDN1; prefoldin subunit 1"
			},
			{
				"name":"143018047 Pfdn5; (RefSeq) prefoldin 5\tK04797 pfdA; prefoldin alpha subunit"
			},
			{
				"name":"143036841 Pfdn6; (RefSeq) prefoldin 6 isoform X1\tK04798 pfdB; prefoldin beta subunit"
			}
			]
		}
		]
	},
	{
		"name":"Other chaperones and cochaperones",
		"children":[
		{
			"name":"Calnexin \/ calreticulin",
			"children":[
			{
				"name":"143033492 calnexin-like isoform X1\tK08054 CANX; calnexin"
			},
			{
				"name":"143028546 Calr; (RefSeq) calreticulin\tK08057 CALR; calreticulin"
			}
			]
		},
		{
			"name":"DegP \/ HtrA",
			"children":[
			{
				"name":"143035912 serine protease HTRA2, mitochondrial-like\tK08669 HTRA2; HtrA serine peptidase 2 [EC:3.4.21.108]"
			}
			]
		},
		{
			"name":"AAA proteases",
			"children":[
			{
				"name":"143034464 Spg7; (RefSeq) SPG7 matrix AAA peptidase subunit, paraplegin\tK09552 SPG7; spastic paraplegia 7 [EC:3.4.24.-]"
			},
			{
				"name":"143024866 Afg3l2; (RefSeq) AFG3 like matrix AAA peptidase subunit 2\tK08956 AFG3; AFG3 family protein [EC:3.4.24.-]"
			}
			]
		},
		{
			"name":"PapD"
		},
		{
			"name":"SecB"
		},
		{
			"name":"Sti1 \/ p60"
		},
		{
			"name":"Cdc37 \/ p50"
		},
		{
			"name":"BAG",
			"children":[
			{
				"name":"143034383 BAG family molecular chaperone regulator 1-like isoform X1\tK09555 BAG1; BCL2-associated athanogene 1"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"143033817 STUB1; (RefSeq) STIP1 homology and U-box containing protein 1 isoform X1\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
			},
			{
				"name":"143018274 hsp70-binding protein 1 isoform X1\tK09562 HSPBP1; hsp70-interacting protein"
			},
			{
				"name":"143029582 protein OPI10 homolog\tK23327 HIKESHI; protein Hikeshi"
			},
			{
				"name":"143027589 mora; (RefSeq) cysteine and histidine rich domain containing protein isoform X1\tK16729 CHORDC1; cysteine and histidine-rich domain-containing protein"
			},
			{
				"name":"143037047 prolyl 3-hydroxylase 1-like\tK08134 P3H1; procollagen-proline 3-dioxygenase 1 [EC:1.14.11.7]"
			},
			{
				"name":"143022502 histone-arginine methyltransferase METTL23-like\tK23151 METTL23; methyltransferase-like protein 23 [EC:2.1.1.-]"
			},
			{
				"name":"143022155 unc-45; (RefSeq) unc-45 myosin chaperone\tK21991 UNC45; protein unc-45"
			},
			{
				"name":"143034609 CNPYb; (RefSeq) FGF signaling regulator protein canopy b\tK22816 CNPY3_4; protein canopy 3\/4"
			},
			{
				"name":"143027248 torsin-1A-like isoform X1\tK22990 TOR1; torsin-1"
			},
			{
				"name":"143040424 torsin-1A-interacting protein 2-like\tK23001 TOR1AIP; torsin-1A-interacting protein"
			},
			{
				"name":"143041478 SPARC; (RefSeq) secreted protein, acidic, cysteine-rich\tK24262 SPARC; secreted protein acidic and rich in cysteine"
			},
			{
				"name":"143026232 small glutamine-rich tetratricopeptide repeat-containing protein alpha-like isoform X1\tK16365 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha"
			},
			{
				"name":"143022548 tetratricopeptide repeat protein 1-like\tK24926 TTC1; tetratricopeptide repeat protein 1"
			},
			{
				"name":"143040351 Dpit47; (RefSeq) DNA polymerase interacting tpr containing protein of 47kD isoform X1\tK24927 TTC4; tetratricopeptide repeat protein 4"
			},
			{
				"name":"143028457 PAT complex subunit Asterix\tK24963 WDR83OS; PAT complex subunit Asterix"
			},
			{
				"name":"143036491 boca; (RefSeq) LDLR chaperone boca\tK25366 MESD; LRP chaperone MESD"
			},
			{
				"name":"143036826 cytochrome b-245 chaperone 1-like\tK25863 CYBC1; cytochrome b-245 chaperone 1"
			},
			{
				"name":"143029150 activator of 90 kDa heat shock protein ATPase homolog 1 isoform X1\tK26216 AHSA1; activator of Hsp90 ATPase protein 1"
			},
			{
				"name":"143029306 putative acetylcholine receptor chaperone\tK26241 NACHO; novel acetylcholine receptor chaperone"
			},
			{
				"name":"143025558 huntingtin-interacting protein K\tK28128 HYPK; huntingtin-interacting protein K"
			},
			{
				"name":"143027540 phosducin-like protein 1\tK28206 PDCL; phosducin-like protein"
			},
			{
				"name":"143028594 phosducin-like protein 1\tK28206 PDCL; phosducin-like protein"
			}
			]
		}
		]
	},
	{
		"name":"Intramolecular chaperones",
		"children":[
		{
			"name":"Subtilisin family",
			"children":[
			{
				"name":"143032293 S1P; (RefSeq) membrane-bound transcription factor site-1 protease\tK08653 MBTPS1; membrane-bound transcription factor site-1 protease [EC:3.4.21.112]"
			},
			{
				"name":"143027766 neuroendocrine convertase 1-like isoform X1\tK01359 PCSK1; proprotein convertase subtilisin\/kexin type 1 [EC:3.4.21.93]"
			},
			{
				"name":"143035713 amon; (RefSeq) prohormone processing protease amontillado\tK01360 PCSK2; proprotein convertase subtilisin\/kexin type 2 [EC:3.4.21.94]"
			},
			{
				"name":"143027039 Fur2; (RefSeq) furin-like protease 2\tK08654 PCSK5; proprotein convertase subtilisin\/kexin type 5 [EC:3.4.21.-]"
			},
			{
				"name":"143021401 TppII; (RefSeq) tripeptidyl-peptidase II isoform X1\tK01280 TPP2; tripeptidyl-peptidase II [EC:3.4.14.10]"
			}
			]
		},
		{
			"name":"Papain family",
			"children":[
			{
				"name":"143026292 cathepsin B-like\tK01363 CTSB; cathepsin B [EC:3.4.22.1]"
			},
			{
				"name":"143027224 cathepsin B-like\tK01363 CTSB; cathepsin B [EC:3.4.22.1]"
			},
			{
				"name":"143017736 dipeptidyl peptidase 1-like isoform X1\tK01275 CTSC; cathepsin C [EC:3.4.14.1]"
			},
			{
				"name":"143022077 procathepsin L-like\tK01365 CTSL; cathepsin L [EC:3.4.22.15]"
			},
			{
				"name":"143022111 CtsL1; (RefSeq) cathepsin L\tK01365 CTSL; cathepsin L [EC:3.4.22.15]"
			},
			{
				"name":"143029847 procathepsin L-like\tK01365 CTSL; cathepsin L [EC:3.4.22.15]"
			},
			{
				"name":"143029849 procathepsin L-like\tK01365 CTSL; cathepsin L [EC:3.4.22.15]"
			}
			]
		},
		{
			"name":"Other peptidases",
			"children":[
			{
				"name":"143021086 lysosomal protective protein-like\tK13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"143021499 beta-hexosaminidase subunit alpha-like\tK12373 HEXA_B; hexosaminidase [EC:3.2.1.52]"
			},
			{
				"name":"143023992 Hexo1; (RefSeq) beta-hexosaminidase 1\tK12373 HEXA_B; hexosaminidase [EC:3.2.1.52]"
			},
			{
				"name":"143034027 beta-hexosaminidase subunit beta-like\tK12373 HEXA_B; hexosaminidase [EC:3.2.1.52]"
			},
			{
				"name":"143036401 chitooligosaccharidolytic beta-N-acetylglucosaminidase-like\tK12373 HEXA_B; hexosaminidase [EC:3.2.1.52]"
			},
			{
				"name":"143036402 chitooligosaccharidolytic beta-N-acetylglucosaminidase-like\tK12373 HEXA_B; hexosaminidase [EC:3.2.1.52]"
			}
			]
		}
		]
	},
	{
		"name":"Protein folding catalysts",
		"children":[
		{
			"name":"Peptidyl prolyl isomerase",
			"children":[
			{
				"name":"Cyclophilin",
				"children":[
				{
					"name":"143038563 peptidyl-prolyl cis-trans isomerase-like\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]"
				},
				{
					"name":"143041077 uncharacterized protein LOC143041077\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]"
				},
				{
					"name":"143024078 peptidyl-prolyl cis-trans isomerase B-like\tK03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]"
				},
				{
					"name":"143024079 peptidyl-prolyl cis-trans isomerase 6-like\tK03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]"
				},
				{
					"name":"143040666 peptidyl-prolyl cis-trans isomerase B-like\tK03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]"
				},
				{
					"name":"143026579 peptidyl-prolyl cis-trans isomerase D-like isoform X1\tK05864 PPID; peptidyl-prolyl isomerase D [EC:5.2.1.8]"
				},
				{
					"name":"143020568 peptidyl-prolyl cis-trans isomerase-like\tK09565 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]"
				},
				{
					"name":"143020659 peptidyl-prolyl cis-trans isomerase-like\tK09565 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]"
				},
				{
					"name":"143036720 peptidyl-prolyl cis-trans isomerase-like\tK09565 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]"
				},
				{
					"name":"143039863 Moca-cyp; (RefSeq) nuclear cyclophilin protein Moca-cyp isoform X1\tK09566 PPIG; peptidyl-prolyl isomerase G (cyclophilin G) [EC:5.2.1.8]"
				},
				{
					"name":"143041827 peptidyl-prolyl cis-trans isomerase H\tK09567 PPIH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]"
				},
				{
					"name":"143028276 Cypl; (RefSeq) peptidyl-prolyl cis-trans isomerase-like 1 Cypl\tK12733 PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]"
				},
				{
					"name":"143019097 RING-type E3 ubiquitin-protein ligase PPIL2\tK10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]"
				},
				{
					"name":"143032406 peptidyl-prolyl cis-trans isomerase sig-7\tK12735 PPIL4; peptidyl-prolyl cis-trans isomerase-like 4 [EC:5.2.1.8]"
				},
				{
					"name":"143040062 spliceosome-associated protein CWC27 homolog\tK12737 SDCCAG10; peptidyl-prolyl cis-trans isomerase SDCCAG10 [EC:5.2.1.8]"
				}
				]
			},
			{
				"name":"FKBP",
				"children":[
				{
					"name":"143032800 Fkbp12; (RefSeq) peptidyl-prolyl cis-trans isomerase Fkbp12 isoform X1\tK09568 FKBP1; FK506-binding protein 1 [EC:5.2.1.8]"
				},
				{
					"name":"143040249 peptidyl-prolyl cis-trans isomerase FKBP2-like\tK09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8]"
				},
				{
					"name":"143024757 zda; (RefSeq) peptidyl-prolyl cis-trans isomerase zonda\tK09574 FKBP8; FK506-binding protein 8 [EC:5.2.1.8]"
				},
				{
					"name":"143018484 peptidyl-prolyl cis-trans isomerase FKBP10-like\tK09575 FKBP9_10; FK506-binding protein 9\/10 [EC:5.2.1.8]"
				}
				]
			},
			{
				"name":"Parvulin"
			}
			]
		},
		{
			"name":"Protein disulfide isomerase",
			"children":[
			{
				"name":"143024726 Trx2; (RefSeq) thioredoxin 2\tK03671 TXN; thioredoxin"
			},
			{
				"name":"143038533 thioredoxin, mitochondrial-like\tK03671 TXN; thioredoxin"
			},
			{
				"name":"143022581 uncharacterized protein LOC143022581 isoform X1\tK03676 grxC; glutaredoxin 3"
			},
			{
				"name":"143037881 uncharacterized protein LOC143037881\tK17479 GRXCR1; glutaredoxin domain-containing cysteine-rich protein 1"
			},
			{
				"name":"143026441 Pdi; (RefSeq) protein disulfide isomerase isoform X1\tK09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]"
			},
			{
				"name":"143040283 putative protein disulfide-isomerase A4\tK09582 PDIA4; protein disulfide-isomerase A4 [EC:5.3.4.1]"
			},
			{
				"name":"143025596 protein disulfide-isomerase TMX3-like isoform X1\tK09585 TMX3; protein disulfide-isomerase [EC:5.3.4.1]"
			}
			]
		}
		]
	}
	]
}