{
	"name":"paeu03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III",
				"children":[
				{
					"name":"BN889_04925 putative cytochrome b\tK00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit"
				}
				]
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"BN889_05281 infB_1; translation initiation factor IF-2\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"BN889_03032 infC; translation initiation factor IF-3\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"BN889_04046 tsf; elongation factor Ts\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"BN889_02264 fusA1; elongation factor G\tK02355 fusA; elongation factor G"
				},
				{
					"name":"BN889_04741 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"BN889_00796 era; GTP-binding protein Era\tK03595 era; GTPase"
				},
				{
					"name":"BN889_00755 tyrZ; tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"BN889_04596 tyrS; tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"BN889_04433 leuS; leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"BN889_01015 aspS; aspartyl-tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"BN889_05609 argS; arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"BN889_06168 gatA; aspartyl\/glutamyl-tRNA amidotransferase subunit A\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"BN889_06169 aspartyl\/glutamyl-tRNA amidotransferase subunit B\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"BN889_06167 gatC; aspartyl\/glutamyl-tRNA amidotransferase subunit C\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors",
				"children":[
				{
					"name":"BN889_01434 protease\tK01173 ENDOG; endonuclease G, mitochondrial"
				},
				{
					"name":"BN889_06759 DNA primase\/helicase\tK17680 TWNK; twinkle mtDNA helicase [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"BN889_02142 ssb_1; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"BN889_04707 ssb_2; single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"BN889_06428 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"BN889_06470 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"BN889_07192 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"BN889_04039 yaeT; outer membrane protein assembly complex, YaeT protein\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"BN889_05301 molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"BN889_05302 grpE; heat shock protein GrpE\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"BN889_04877 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"BN889_04878 groES; co-chaperonin GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"BN889_05300 dnaJ; chaperone protein DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"BN889_02264 fusA1; elongation factor G\tK02355 fusA; elongation factor G"
				},
				{
					"name":"BN889_04741 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"BN889_02255 putative pyridoxal-phosphate dependent enzyme\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"BN889_04241 iscS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"BN889_05301 molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"BN889_04238 hscB; co-chaperone HscB\tK04082 hscB; molecular chaperone HscB"
				},
				{
					"name":"BN889_03903 glutaredoxin-like protein\tK07390 grxD; monothiol glutaredoxin"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"BN889_03867 ParA family protein\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"BN889_00163 protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"BN889_01425 cyoE; protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"BN889_00157 cytochrome C oxidase assembly protein\tK02258 COX11; cytochrome c oxidase assembly protein subunit 11"
				},
				{
					"name":"BN889_00162 putative cytochrome oxidase assembly protein\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"BN889_00022 putative inner membrane protein translocase component YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"BN889_00160 surf1; protein Surf1\tK14998 SURF1; surfeit locus 1 family protein"
				},
				{
					"name":"BN889_00164 putative Sco1\/SenC family protein\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"BN889_01131 putative heat shock protein (hsp90 family)\tK04079 HSP90A; molecular chaperone HtpG"
				},
				{
					"name":"BN889_01709 htpG; heat shock protein 90\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}