{
	"name":"paj01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"PAJ_1508 cmr; multidrug translocase MdfA Cmr\tK08160 mdfA; MFS transporter, DHA1 family, multidrug\/chloramphenicol efflux transport protein"
				},
				{
					"name":"PAJ_3773 cmr; multidrug translocase Cmr\tK08160 mdfA; MFS transporter, DHA1 family, multidrug\/chloramphenicol efflux transport protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"PAJ_0790 smvA; methyl viologen resistance protein SmvA\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"PAJ_1103 bla; beta-lactamase CTX-M-2 precursor Bla\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"PAJ_2977 ddpX; D-alanyl-D-alanine dipeptidase DdpX\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"PAJ_0856 phoQ; virulence sensor histidine kinase PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"PAJ_0857 phoP; transcriptional regulatory protein PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				},
				{
					"name":"PAJ_1211 phoP; transcriptional regulatory protein PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"PAJ_0348 acrA; acriflavine resistance protein A precursor AcrA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"PAJ_0876 mexA; multidrug resistance protein MexA precursor MexA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"PAJ_0347 acrB; acriflavine resistance protein B AcrB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"PAJ_0875 acrB; acriflavine resistance protein B AcrB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"PAJ_0782 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PAJ_0874 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PAJ_3630 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"PAJ_0782 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PAJ_0874 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PAJ_3630 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"PAJ_0782 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PAJ_0874 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PAJ_3630 oprM; outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"PAJ_0367 cueR; HTH-type transcriptional regulator CueR\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]",
				"children":[
				{
					"name":"PAJ_2245 baeS; sensor protein BaeS\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"PAJ_2244 baeR; transcriptional regulatory protein BaeR\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
				},
				{
					"name":"PAJ_2242 acrB; acriflavine resistance protein B AcrB\tK18146 adeB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"PAJ_1260 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"PAJ_2618 tolC; outer membrane protein tolC precursor TolC\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"PAJ_1260 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"PAJ_2618 tolC; outer membrane protein tolC precursor TolC\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"PAJ_0790 smvA; methyl viologen resistance protein SmvA\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]",
				"children":[
				{
					"name":"PAJ_1175 marA; multiple antibiotic resistance protein MarA\tK13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"PAJ_3470 marA; multiple antibiotic resistance protein MarA\tK13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"PAJ_0693 ompF; outer membrane protein F precursor OmpF\tK09476 ompF; outer membrane pore protein F"
				},
				{
					"name":"PAJ_1023 ompF; outer membrane protein F precursor OmpF\tK09476 ompF; outer membrane pore protein F"
				},
				{
					"name":"PAJ_3001 ompF; outer membrane protein F precursor OmpF\tK09476 ompF; outer membrane pore protein F"
				}
				]
			}
			]
		}
		]
	}
	]
}