{
	"name":"panp02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins"
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"PSNIH2_01480 Restriction endonuclease, type I, EcoRI, R subunit\/Type III\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"PSNIH2_01500 restriction endonuclease subunit M\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"PSNIH2_18930 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"PSNIH2_20995 DNA modification methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"PSNIH2_05570 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"PSNIH2_19775 modification methylase EcoRII\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"PSNIH2_20155 DNA methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"PSNIH2_20845 DNA methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"PSNIH2_21775 DNA cytosine methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"PSNIH2_23120 HNH endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"PSNIH2_19785 TetR family transcriptional regulator\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"PSNIH2_09395 endoribonuclease symE\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF",
				"children":[
				{
					"name":"PSNIH2_06600 toxin YhaV\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"PSNIH2_06595 AbrB family transcriptional regulator\tK19156 prlF; antitoxin PrlF"
				}
				]
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"PSNIH2_22165 RelE toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"PSNIH2_22170 bifunctional antitoxin\/transcriptional repressor RelB\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"PSNIH2_21065 damage-inducible protein J\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"PSNIH2_22330 transcriptional regulator\tK15773 hipB; HTH-type transcriptional regulator \/ antitoxin HipB"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"PSNIH2_07775 transcriptional regulator\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"PSNIH2_07770 pspB; phage shock protein\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"PSNIH2_02505 twitching motility protein PilT\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"PSNIH2_03315 plasmid maintenance protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"PSNIH2_02510 virulence factor\tK18829 mvpT; antitoxin VapB"
				},
				{
					"name":"PSNIH2_03310 antitoxin\tK18829 mvpT; antitoxin VapB"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"PSNIH2_14265 hypothetical protein\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"PSNIH2_14420 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"PSNIH2_16165 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"PSNIH2_01285 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"PSNIH2_01265 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"PSNIH2_03785 gltX; glutamyl-tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"PSNIH2_15530 toxin YkfI\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"PSNIH2_15535 Mu phage lytic protein YfjZ\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"PSNIH2_01945 hypothetical protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"PSNIH2_01940 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"PSNIH2_12600 gene expression modulator\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"PSNIH2_22430 regulatory protein\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"PSNIH2_12595 Hha toxicity attenuator\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"PSNIH2_03155 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"PSNIH2_20825 phosphoadenosine phosphosulfate reductase\tK19170 dndC; DNA sulfur modification protein DndC"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}