{
	"name":"pare03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"PYJP_08790 hypothetical protein\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"PYJP_18490 hypothetical protein\tK03537 POP5; ribonuclease P\/MRP protein subunit POP5 [EC:3.1.26.5]"
				},
				{
					"name":"PYJP_18500 hypothetical protein\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				},
				{
					"name":"PYJP_14170 hypothetical protein\tK03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"PYJP_01170 hypothetical protein\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				},
				{
					"name":"PYJP_07850 MBL fold metallo-hydrolase\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"PYJP_00110 RtcB family protein\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				},
				{
					"name":"PYJP_11480 archease\tK24956 ZBTB8OS; protein archease"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"PYJP_13900 tuf; translation elongation factor EF-1 subunit alpha\tK03231 EEF1A; elongation factor 1-alpha"
				}
				]
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"PYJP_18610 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"PYJP_05120 proS; proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"PYJP_07600 ileS; isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"PYJP_09760 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"PYJP_10390 metG_1; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"PYJP_10090 arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"PYJP_14320 alaS; alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"PYJP_17590 asnS; asparagine--tRNA ligase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"PYJP_15460 glyS; glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"PYJP_03220 threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"PYJP_09840 serS; serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"PYJP_09250 cysS; cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"PYJP_04240 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"PYJP_03340 hisS; histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"PYJP_03930 phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"PYJP_03920 pheT; phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"PYJP_03910 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"PYJP_10770 tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"PYJP_05100 D-aminoacyl-tRNA deacylase\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"PYJP_09490 alaXM; alanyl-tRNA editing protein AlaXM\tK07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]"
				}
				]
			},
			{
				"name":"AARS associated factors"
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"PYJP_13700 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotran sferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"PYJP_19580 tRNA (guanine(10)-N(2))-dimethyltransferase\tK00555 TRMT1; tRNA (guanine26-N2\/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]"
				},
				{
					"name":"PYJP_13340 class I SAM-dependent methyltransferase family protein\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"PYJP_16060 methyltransferase\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"PYJP_02570 tRNA (adenine-N1)-methyltransferase\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]"
				},
				{
					"name":"PYJP_10460 twy1; 4-demethylwyosine synthase TYW1\tK15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]"
				},
				{
					"name":"PYJP_04760 hypothetical protein\tK15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]"
				},
				{
					"name":"PYJP_15210 hypothetical protein\tK15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"PYJP_08590 RNA-guided pseudouridylation complex pseudouridine synthase subunit Cbf5\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"PYJP_13420 truD; tRNA pseudouridine(13) synthase TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"PYJP_14800 tRNA pseudouridine(54\/55) synthase Pus10\tK07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors"
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"PYJP_19810 Kae1-associated kinase Bud32\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]"
				},
				{
					"name":"PYJP_19800 kae1; KEOPS complex N(6)-L-threonylcarbamoyladenine synthase Kae1\tK01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]"
				}
				]
			},
			{
				"name":"Elongator complex"
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"PYJP_07520 hypothetical protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"PYJP_19870 SPOUT family RNA methylase\tK06963 TAN1; tRNA acetyltransferase TAN1"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors"
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"PYJP_08100 RNA ligase partner protein\tK09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"PYJP_01170 hypothetical protein\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				},
				{
					"name":"PYJP_07850 MBL fold metallo-hydrolase\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"PYJP_15100 cca; CCA tRNA nucleotidyltransferase\tK07558 K07558; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases",
				"children":[
				{
					"name":"PYJP_03330 hypothetical protein\tK01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]"
				},
				{
					"name":"PYJP_15410 endA; tRNA-intron lyase\tK01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]"
				}
				]
			},
			{
				"name":"tRNA splicing ligases",
				"children":[
				{
					"name":"PYJP_00110 RtcB family protein\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"PYJP_11000 thpR; RNA 2',3'-cyclic phosphodiesterase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				},
				{
					"name":"PYJP_18950 RNA 2'-phosphotransferase\tK07559 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"PYJP_09760 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"PYJP_15510 lysS; lysine--tRNA ligase\tK04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]"
				},
				{
					"name":"PYJP_05120 proS; proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"PYJP_03910 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"PYJP_10770 tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"PYJP_03220 threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"PYJP_07600 ileS; isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"PYJP_14320 alaS; alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"PYJP_04240 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"PYJP_10390 metG_1; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"PYJP_09840 serS; serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"PYJP_09250 cysS; cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"PYJP_18610 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"PYJP_10090 arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"PYJP_03930 phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"PYJP_03920 pheT; phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"PYJP_03340 hisS; histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"PYJP_17590 asnS; asparagine--tRNA ligase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"PYJP_15290 aspS; aspartate--tRNA(Asn) ligase\tK09759 aspC; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"PYJP_05100 D-aminoacyl-tRNA deacylase\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"PYJP_09490 alaXM; alanyl-tRNA editing protein AlaXM\tK07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"PYJP_13700 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotran sferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"PYJP_04350 hypothetical protein\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]"
				},
				{
					"name":"PYJP_05150 hypothetical protein\tK16317 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257]"
				},
				{
					"name":"PYJP_16100 hypothetical protein\tK15566 trm10; tRNA (adenine9-N1\/guanine9-N1)-methyltransferase [EC:2.1.1.218 2.1.1.221]"
				},
				{
					"name":"PYJP_14730 trm14; tRNA (guanine(6)-N2)-methyltransferase\tK16318 trm14; tRNA (guanine6-N2)-methyltransferase [EC:2.1.1.256]"
				},
				{
					"name":"PYJP_04690 tRNA (cytidine(56)-2'-O)-methyltransferase\tK07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"PYJP_08590 RNA-guided pseudouridylation complex pseudouridine synthase subunit Cbf5\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"PYJP_13420 truD; tRNA pseudouridine(13) synthase TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"PYJP_16010 TIGR00269 family protein\tK21947 ttuA; tRNA-5-methyluridine54 2-sulfurtransferase [EC:2.8.1.15]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"PYJP_19810 Kae1-associated kinase Bud32\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]"
				},
				{
					"name":"PYJP_19800 kae1; KEOPS complex N(6)-L-threonylcarbamoyladenine synthase Kae1\tK01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]"
				},
				{
					"name":"PYJP_18310 hypothetical protein\tK09741 pcc1; KEOPS complex subunit Pcc1"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"PYJP_16840 7-cyano-7-deazaguanine synthase\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"PYJP_04480 hypothetical protein\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"PYJP_06440 queD; 6-carboxytetrahydropterin synthase QueD\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"PYJP_06450 7-carboxy-7-deazaguanine synthase QueE\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"PYJP_05780 hypothetical protein\tK09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]"
				},
				{
					"name":"PYJP_19390 tgtA; tRNA guanosine(15) transglycosylase TgtA\tK18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]"
				},
				{
					"name":"PYJP_18410 thiI; tRNA 4-thiouridine(8) synthase ThiI\tK03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]"
				},
				{
					"name":"PYJP_15050 tiaS; tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS\tK06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]"
				},
				{
					"name":"PYJP_03350 tRNA(Met) cytidine acetyltransferase TmcA\tK06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]"
				},
				{
					"name":"PYJP_04850 tRNA(Met) cytidine acetyltransferase TmcA\tK06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]"
				},
				{
					"name":"PYJP_17760 hypothetical protein\tK06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]"
				},
				{
					"name":"PYJP_07520 hypothetical protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors"
		}
		]
	}
	]
}