{
	"name":"pbi03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"103048170 ORC1; origin recognition complex subunit 1\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"103050214 ORC2; origin recognition complex subunit 2 isoform X1\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"103066500 ORC3; origin recognition complex subunit 3 isoform X1\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"103054302 ORC4; origin recognition complex subunit 4\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"103054984 ORC5; origin recognition complex subunit 5\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"103059632 ORC6; origin recognition complex subunit 6\tK02608 ORC6; origin recognition complex subunit 6"
				},
				{
					"name":"103067886 CDT1; DNA replication factor Cdt1\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"103066412 CDC6; cell division control protein 6 homolog isoform X1\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"103057843 MCM2; DNA replication licensing factor MCM2\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"103059015 MCM3; DNA replication licensing factor MCM3\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"103061138 MCM4; DNA replication licensing factor MCM4\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"103065648 MCM5; DNA replication licensing factor MCM5\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"103054193 MCM6; DNA replication licensing factor MCM6\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"103066796 MCM7; DNA replication licensing factor MCM7\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)",
				"children":[
				{
					"name":"103062100 CCNA1; cyclin-A1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"103067870 CCNA2; cyclin-A2\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"103052775 CCNE1; G1\/S-specific cyclin-E1\tK06626 CCNE; G1\/S-specific cyclin-E1"
				},
				{
					"name":"103066008 CCNE2; G1\/S-specific cyclin-E2\tK06626 CCNE; G1\/S-specific cyclin-E1"
				},
				{
					"name":"103054413 CDK2; cyclin-dependent kinase 2\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"
				}
				]
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"103056065 CDC7; cell division cycle 7-related protein kinase isoform X1\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				},
				{
					"name":"103064107 DBF4; protein DBF4 homolog A\tK06629 DBF4; protein DBF4"
				},
				{
					"name":"112540266 DBF4B; protein DBF4 homolog B\tK06629 DBF4; protein DBF4"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"103063190 GINS1; DNA replication complex GINS protein PSF1\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"103061356 GINS2; DNA replication complex GINS protein PSF2\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"103061231 DNA replication complex GINS protein PSF3-like\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"103061469 DNA replication complex GINS protein PSF3-like\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"103062895 GINS4; DNA replication complex GINS protein SLD5\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"103055805 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
				},
				{
					"name":"103060975 RECQL4; ATP-dependent DNA helicase Q4\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
				},
				{
					"name":"103050196 CDC45; cell division control protein 45 homolog\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"103068233 MCM8; DNA helicase MCM8\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
				},
				{
					"name":"103054389 DNA helicase MCM9-like\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
				},
				{
					"name":"103057984 MCM9; DNA helicase MCM9\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
				},
				{
					"name":"103049094 MCM10; protein MCM10 homolog\tK10736 MCM10; minichromosome maintenance protein 10"
				},
				{
					"name":"103050391 MCMBP; mini-chromosome maintenance complex-binding protein\tK28390 MCMBP; minichromosome maintenance complex-binding protein"
				},
				{
					"name":"103051559 protein FAM111A-like\tK24274 FAM111A; protein FAM111A"
				},
				{
					"name":"103067134 CINP; cyclin-dependent kinase 2-interacting protein isoform X1\tK26052 CINP; cyclin-dependent kinase 2-interacting protein"
				},
				{
					"name":"103067194 MTBP; mdm2-binding protein\tK26116 MTBP; Mdm2-binding protein"
				},
				{
					"name":"103053247 TICRR; treslin\tK26117 TICRR; Treslin"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"103064411 POLA1; DNA polymerase alpha catalytic subunit\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"103063289 POLA2; DNA polymerase alpha subunit B\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"103051389 PRIM1; DNA primase small subunit\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"103048429 PRIM2; DNA primase large subunit\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"103049755 POLE; DNA polymerase epsilon catalytic subunit A\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"103052002 DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				},
				{
					"name":"103058852 DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				},
				{
					"name":"103067387 POLE3; DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"103054637 POLD1; DNA polymerase delta catalytic subunit isoform X2\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"103061070 POLD2; DNA polymerase delta subunit 2 isoform X1\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"103061468 POLD3; DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
				},
				{
					"name":"103062790 POLD4; DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"103062476 POLG; DNA polymerase subunit gamma-1 isoform X1\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				},
				{
					"name":"103051819 POLG2; DNA polymerase subunit gamma-2, mitochondrial\tK02333 POLG2; DNA polymerase gamma 2"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"103054280 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"103054371 RPA2; replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"103051255 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"103054882 RFC1; replication factor C subunit 1 isoform X1\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"103054137 RFC4; replication factor C subunit 4 isoform X2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"103055645 RFC2; replication factor C subunit 2 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"103050610 RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"103050675 RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"103062372 RNASEH1; ribonuclease H1 isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"103048814 RNASEH2A; ribonuclease H2 subunit A isoform X1\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				},
				{
					"name":"103062027 RNASEH2B; ribonuclease H2 subunit B isoform X1\tK10744 RNASEH2B; ribonuclease H2 subunit B"
				},
				{
					"name":"103049603 RNASEH2C; ribonuclease H2 subunit C\tK10745 RNASEH2C; ribonuclease H2 subunit C"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"103055444 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"103060695 PCLAF; PCNA-associated factor\tK28763 PCLAF; PCNA-associated factor"
				},
				{
					"name":"103048518 DNA2; DNA replication ATP-dependent helicase\/nuclease DNA2\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"103053156 flap endonuclease 1-like\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"103063759 FEN1; flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"103048716 EXO1; exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"103062294 ZRANB3; DNA annealing helicase and endonuclease ZRANB3\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				},
				{
					"name":"103064233 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				},
				{
					"name":"103064030 ATAD5; ATPase family AAA domain-containing protein 5\tK26118 ATAD5; ATPase family AAA domain-containing protein 5"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"103051263 DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"103068010 DNMT3B; DNA (cytosine-5)-methyltransferase 3B\tK17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"103063780 GMNN; geminin\tK10749 GMNN; geminin"
				},
				{
					"name":"103052012 MCIDAS; multicilin\tK26119 MCIDAS; multicilin"
				},
				{
					"name":"103056367 CCNB1; G2\/mitotic-specific cyclin-B1 isoform X1\tK05868 CCNB1; G2\/mitotic-specific cyclin-B1"
				},
				{
					"name":"103056997 CCNB3; G2\/mitotic-specific cyclin-B3 isoform X2\tK21771 CCNB3; G2\/mitotic-specific cyclin-B3"
				},
				{
					"name":"103058257 CDK1; cyclin-dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]"
				}
				]
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex",
					"children":[
					{
						"name":"103053531 POT1; protection of telomeres protein 1 isoform X1\tK11109 POT1; protection of telomeres protein 1"
					},
					{
						"name":"103067528 TERF1; telomeric repeat-binding factor 1 isoform X2\tK11110 TERF1; telomeric repeat-binding factor 1"
					},
					{
						"name":"103055944 TERF2; telomeric repeat-binding factor 2\tK11111 TERF2; telomeric repeat-binding factor 2"
					},
					{
						"name":"103063852 TINF2; TERF1-interacting nuclear factor 2\tK11112 TINF2; TERF1-interacting nuclear factor 2"
					},
					{
						"name":"103062803 uncharacterized protein LOC103062803 isoform X1\tK11114 ACD; adrenocortical dysplasia protein"
					}
					]
				},
				{
					"name":"TERB1-TERB2-MAJIN complex",
					"children":[
					{
						"name":"103052879 TERB1; telomere repeats-binding bouquet formation protein 1\tK25749 TERB1; telomere repeats-binding bouquet formation protein 1"
					},
					{
						"name":"112540469 TERB2; telomere repeats-binding bouquet formation protein 2\tK25750 TERB2; telomere repeats-binding bouquet formation protein 2"
					},
					{
						"name":"112540217 MAJIN; membrane-anchored junction protein\tK25751 MAJIN; membrane-anchored junction protein"
					}
					]
				},
				{
					"name":"CST complex (animals)",
					"children":[
					{
						"name":"103059438 CTC1; CST complex subunit CTC1\tK23311 CTC1; CST complex subunit CTC1"
					},
					{
						"name":"103047998 STN1; CST complex subunit STN1\tK23312 STN1; CST complex subunit STN1"
					},
					{
						"name":"103048551 TEN1; CST complex subunit TEN1\tK23313 TEN1; CST complex subunit TEN1"
					}
					]
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"103060578 telomerase-binding protein EST1A\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
				},
				{
					"name":"103068124 telomerase-binding protein EST1A-like isoform X3\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
				},
				{
					"name":"103061764 SMG5; protein SMG5\tK11125 SMG5; protein SMG5"
				},
				{
					"name":"103054955 TERT; telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"103056653 TEP1; telomerase protein component 1\tK11127 TEP1; telomerase protein component 1"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"103060876 GAR1; H\/ACA ribonucleoprotein complex subunit 1\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"103066802 NHP2; H\/ACA ribonucleoprotein complex subunit 2\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"103053480 NOP10; H\/ACA ribonucleoprotein complex subunit 3\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"103053539 DKC1; H\/ACA ribonucleoprotein complex subunit 4 isoform X1\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"103054955 TERT; telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"103059702 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B'\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"103064956 SNRPD1; small nuclear ribonucleoprotein Sm D1\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"103059124 SNRPD2; small nuclear ribonucleoprotein Sm D2\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"107326285 SNRPD3; LOW QUALITY PROTEIN: small nuclear ribonucleoprotein Sm D3\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"103067909 SNRPE; small nuclear ribonucleoprotein E\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"103067306 SNRPF; small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"103054584 SNRPG; small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"103054137 RFC4; replication factor C subunit 4 isoform X2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"103055645 RFC2; replication factor C subunit 2 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"103050610 RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"103050675 RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"103061835 MRE11; double-strand break repair protein MRE11 isoform X1\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"103064733 DNA repair protein RAD50-like\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
				},
				{
					"name":"103053407 NBN; nibrin\tK10867 NBN; nibrin"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"103049413 ATM; serine-protein kinase ATM\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"103066362 WRN; Werner syndrome ATP-dependent helicase\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
				},
				{
					"name":"103060640 BLM; Bloom syndrome protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"103059879 DNA-dependent protein kinase catalytic subunit\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
				},
				{
					"name":"103061618 DNA-dependent protein kinase catalytic subunit\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
				},
				{
					"name":"103062375 ERCC4; DNA repair endonuclease XPF\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"103053160 PARP1; poly [ADP-ribose] polymerase 1 isoform X1\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
				},
				{
					"name":"103057054 PARP2; poly [ADP-ribose] polymerase 2 isoform X1\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
				},
				{
					"name":"103056411 TNKS; tankyrase-1\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"103065834 TNKS2; tankyrase-2\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"103049975 PINX1; PIN2\/TERF1-interacting telomerase inhibitor 1\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"103065692 regulator of telomere elongation helicase 1-like\tK11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]"
				},
				{
					"name":"103055512 TELO2; telomere length regulation protein TEL2 homolog isoform X1\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"103067587 TRIR; telomerase RNA component interacting RNase\tK01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]"
				},
				{
					"name":"103050445 RIF1; telomere-associated protein RIF1\tK11138 RIF1; telomere-associated protein RIF1"
				},
				{
					"name":"103065091 PIF1; ATP-dependent DNA helicase PIF1\tK15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]"
				},
				{
					"name":"103057290 PURA; transcriptional activator protein Pur-alpha\tK21772 PURA; transcriptional activator protein Pur-alpha"
				},
				{
					"name":"103055094 PURG; purine-rich element-binding protein gamma\tK21800 PURG; purine-rich element-binding protein gamma"
				},
				{
					"name":"103060460 WRAP53; telomerase Cajal body protein 1\tK23314 WRAP53; telomerase Cajal body protein 1"
				},
				{
					"name":"103065338 SDE2; replication stress response regulator SDE2\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"103058208 RTF2; protein RTF2 homolog\tK25186 RTF2; replication termination factor 2"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"103063847 TOP1MT; DNA topoisomerase I, mitochondrial isoform X2\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"103065261 TOP1; DNA topoisomerase 1\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"103063882 TOP2B; DNA topoisomerase 2-beta\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"103065748 TOP2A; DNA topoisomerase 2-alpha\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"103052651 TOP3B; DNA topoisomerase 3-beta-1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"103060611 TOP3A; DNA topoisomerase 3-alpha isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"103055480 SSBP1; single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"103062372 RNASEH1; ribonuclease H1 isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"103062372 RNASEH1; ribonuclease H1 isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"103048518 DNA2; DNA replication ATP-dependent helicase\/nuclease DNA2\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"103053156 flap endonuclease 1-like\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"103063759 FEN1; flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"103064233 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	}
	]
}