{ "name":"pbrv01001", "children":[ { "name":"Serine\/threonine kinases: AGC group", "children":[ { "name":"PKA family", "children":[ { "name":"138157385 PRKACA; (RefSeq) cAMP-dependent protein kinase catalytic subunit alpha isoform X1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"138166178 PRKACB; (RefSeq) cAMP-dependent protein kinase catalytic subunit beta isoform X1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"138149672 PRKX; (RefSeq) cAMP-dependent protein kinase catalytic subunit PRKX isoform X1\tK19584 PRKX; protein kinase X [EC:2.7.11.11]" } ] }, { "name":"PKG family", "children":[ { "name":"138172163 PRKG1; (RefSeq) cGMP-dependent protein kinase 1 isoform X1\tK07376 PRKG1; cGMP-dependent protein kinase 1 [EC:2.7.11.12]" }, { "name":"138169129 PRKG2; (RefSeq) cGMP-dependent protein kinase 2\tK19477 PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12]" } ] }, { "name":"PKC family [OT]", "children":[ { "name":"138152611 PRKCA; (RefSeq) protein kinase C alpha type isoform X1\tK02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]" }, { "name":"138175800 PRKCB; (RefSeq) protein kinase C beta type isoform X1\tK19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]" }, { "name":"138173391 PRKCG; (RefSeq) protein kinase C gamma type\tK19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]" }, { "name":"138166991 PRKCD; (RefSeq) protein kinase C delta type\tK06068 PRKCD; novel protein kinase C delta type [EC:2.7.11.13]" }, { "name":"138148800 PRKCE; (RefSeq) protein kinase C epsilon type\tK18050 PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]" }, { "name":"138164335 PRKCH; (RefSeq) protein kinase C eta type\tK18051 PRKCH; novel protein kinase C eta type [EC:2.7.11.13]" }, { "name":"138175813 protein kinase C theta type\tK18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]" }, { "name":"138176134 protein kinase C theta type\tK18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]" }, { "name":"138154194 PRKCZ; (RefSeq) protein kinase C zeta type isoform X1\tK18952 PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]" }, { "name":"138157769 PRKCI; (RefSeq) protein kinase C iota type isoform X1\tK06069 PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]" } ] }, { "name":"PKN family", "children":[ { "name":"138157373 PKN1; (RefSeq) serine\/threonine-protein kinase N1 isoform X1\tK06071 PKN1; serine\/threonine-protein kinase N1 [EC:2.7.11.13]" }, { "name":"138166143 PKN2; (RefSeq) serine\/threonine-protein kinase N2 isoform X1\tK23691 PKN2; serine\/threonine-protein kinase N2 [EC:2.7.11.13]" }, { "name":"138147154 PKN3; (RefSeq) serine\/threonine-protein kinase N3 isoform X1\tK23692 PKN3; serine\/threonine-protein kinase N3 [EC:2.7.11.13]" } ] }, { "name":"AUR family [OT]", "children":[ { "name":"138149439 AURKA; (RefSeq) LOW QUALITY PROTEIN: aurora kinase A\tK11481 AURKA; aurora kinase A [EC:2.7.11.1]" }, { "name":"138174003 AURKB; (RefSeq) aurora kinase B\tK11479 AURKB; aurora kinase B [EC:2.7.11.1]" } ] }, { "name":"PDK1 family", "children":[ { "name":"138176766 PDPK1; (RefSeq) 3-phosphoinositide-dependent protein kinase 1\tK06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]" } ] }, { "name":"AKT\/PKB family", "children":[ { "name":"138143237 AKT3; (RefSeq) RAC-gamma serine\/threonine-protein kinase\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"138154252 AKT2; (RefSeq) RAC-beta serine\/threonine-protein kinase\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"138173755 AKT1; (RefSeq) RAC-alpha serine\/threonine-protein kinase isoform X1\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" } ] }, { "name":"SGK family [OT]", "children":[ { "name":"138153201 SGK1; (RefSeq) serine\/threonine-protein kinase Sgk1 isoform X1\tK13302 SGK1; serum\/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]" }, { "name":"138153470 SGK2; (RefSeq) serine\/threonine-protein kinase Sgk2\tK13303 SGK2; serum\/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]" }, { "name":"138170610 SGK3; (RefSeq) serine\/threonine-protein kinase Sgk3 isoform X1\tK13304 SGK3; serum\/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]" } ] }, { "name":"RSK family [OT]", "children":[ { "name":"138142384 RPS6KA3; (RefSeq) ribosomal protein S6 kinase alpha-3 isoform X1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"138145740 RPS6KA6; (RefSeq) ribosomal protein S6 kinase alpha-6\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"138147815 RPS6KA2; (RefSeq) ribosomal protein S6 kinase alpha-2\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"138154501 RPS6KA1; (RefSeq) ribosomal protein S6 kinase alpha-1 isoform X1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"138144813 RPS6KA4; (RefSeq) ribosomal protein S6 kinase alpha-4 isoform X1\tK16510 RPS6KA4; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]" }, { "name":"138159683 RPS6KA5; (RefSeq) ribosomal protein S6 kinase alpha-5 isoform X1\tK04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]" }, { "name":"138153771 RPS6KB1; (RefSeq) ribosomal protein S6 kinase beta-1 isoform X1\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]" }, { "name":"138161665 ribosomal protein S6 kinase beta-2\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]" }, { "name":"138161684 ribosomal protein S6 kinase beta-2\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]" }, { "name":"138164421 RPS6KL1; (RefSeq) ribosomal protein S6 kinase-like 1\tK20839 RSKL; ribosomal protein S6 kinase-like" }, { "name":"138177527 RPS6KC1; (RefSeq) ribosomal protein S6 kinase delta-1 isoform X1\tK20839 RSKL; ribosomal protein S6 kinase-like" } ] }, { "name":"NDR family", "children":[ { "name":"138150132 STK38; (RefSeq) serine\/threonine-protein kinase 38\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]" }, { "name":"138175807 serine\/threonine-protein kinase 38-like\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]" }, { "name":"138176129 serine\/threonine-protein kinase 38-like\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]" }, { "name":"138147296 LATS1; (RefSeq) serine\/threonine-protein kinase LATS1 isoform X1\tK08791 LATS1_2; serine\/threonine-protein kinase LATS1\/2 [EC:2.7.11.1]" }, { "name":"138155219 LATS2; (RefSeq) serine\/threonine-protein kinase LATS2\tK08791 LATS1_2; serine\/threonine-protein kinase LATS1\/2 [EC:2.7.11.1]" } ] }, { "name":"MAST family [OT]", "children":[ { "name":"138143239 microtubule-associated serine\/threonine-protein kinase 3-like\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"138157412 MAST1; (RefSeq) microtubule-associated serine\/threonine-protein kinase 1 isoform X1\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"138165022 microtubule-associated serine\/threonine-protein kinase 2-like\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"138165390 microtubule-associated serine\/threonine-protein kinase 2-like isoform X1\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"138167585 MAST4; (RefSeq) microtubule-associated serine\/threonine-protein kinase 4\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"138159955 MASTL; (RefSeq) serine\/threonine-protein kinase greatwall isoform X1\tK16309 MASTL; serine\/threonine-protein kinase greatwall [EC:2.7.11.36]" } ] }, { "name":"YANK family", "children":[ { "name":"138150604 STK32B; (RefSeq) serine\/threonine-protein kinase 32B\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" }, { "name":"138172110 STK32C; (RefSeq) serine\/threonine-protein kinase 32C\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" }, { "name":"138172789 STK32A; (RefSeq) serine\/threonine-protein kinase 32A isoform X1\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" } ] }, { "name":"DMPK family [OT]", "children":[ { "name":"138161413 DMPK; (RefSeq) myotonin-protein kinase\tK08788 DMPK; dystrophia myotonica-protein kinase [EC:2.7.11.1]" }, { "name":"138170431 ROCK1; (RefSeq) rho-associated protein kinase 1 isoform X1\tK04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.39]" }, { "name":"138146817 ROCK2; (RefSeq) rho-associated protein kinase 2 isoform X1\tK17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.39]" }, { "name":"138144827 CDC42BPG; (RefSeq) serine\/threonine-protein kinase MRCK gamma\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"138146979 CDC42BPA; (RefSeq) serine\/threonine-protein kinase MRCK alpha isoform X1\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"138173720 CDC42BPB; (RefSeq) serine\/threonine-protein kinase MRCK beta\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"138156275 CIT; (RefSeq) citron Rho-interacting kinase isoform X1\tK16308 CIT; citron Rho-interacting kinase [EC:2.7.11.35]" } ] }, { "name":"GRK family [OT]", "children":[ { "name":"138165671 GRK1; (RefSeq) rhodopsin kinase GRK1\tK00909 GRK1_7; rhodopsin kinase [EC:2.7.11.14]" }, { "name":"138174373 GRK7; (RefSeq) rhodopsin kinase GRK7\tK00909 GRK1_7; rhodopsin kinase [EC:2.7.11.14]" }, { "name":"138144911 GRK2; (RefSeq) beta-adrenergic receptor kinase 1\tK00910 ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]" }, { "name":"138156461 GRK3; (RefSeq) G protein-coupled receptor kinase 3 isoform X1\tK00910 ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]" }, { "name":"138148120 GRK4; (RefSeq) G protein-coupled receptor kinase 4 isoform X1\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" }, { "name":"138153559 GRK6; (RefSeq) G protein-coupled receptor kinase 6 isoform X1\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" }, { "name":"138169542 GRK5; (RefSeq) G protein-coupled receptor kinase 5 isoform X1\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" } ] }, { "name":"Other", "children":[ { "name":"138162531 RSKR; (RefSeq) ribosomal protein S6 kinase-related protein\tK17529 SGK494; uncharacterized serine\/threonine-protein kinase SgK494 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CAMK group", "children":[ { "name":"CAMK1 family [OT]", "children":[ { "name":"138151253 CAMK1G; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1G isoform X1\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"138158077 CAMK1; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1 isoform X1\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"138175840 CAMK1D; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1D isoform X1\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"138175992 calcium\/calmodulin-dependent protein kinase type 1D isoform X1\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"138167356 CAMK4; (RefSeq) calcium\/calmodulin-dependent protein kinase type IV\tK05869 CAMK4; calcium\/calmodulin-dependent protein kinase IV [EC:2.7.11.17]" }, { "name":"138177327 PNCK; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1B\tK08795 PNCK; pregnancy upregulated non-ubiquitously expressed CaM kinase [EC:2.7.11.17]" }, { "name":"138166948 CAMKV; (RefSeq) caM kinase-like vesicle-associated protein\tK08812 CAMKV; CaM kinase-like vesicle-associated [EC:2.7.11.-]" } ] }, { "name":"CAMK2 family", "children":[ { "name":"138146407 CAMK2G; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit gamma isoform X1\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"138148979 CAMK2B; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit beta\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"138166947 CAMK2D; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit delta isoform X1\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"138172775 CAMK2A; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit alpha isoform X1\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" } ] }, { "name":"CAMKL family", "children":[ { "name":"138176551 BRSK2; (RefSeq) serine\/threonine-protein kinase BRSK2 isoform X1\tK08796 BRSK; BR serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"138155438 CHEK1; (RefSeq) serine\/threonine-protein kinase Chk1 isoform X1\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]" }, { "name":"138162614 LOW QUALITY PROTEIN: serine\/threonine-protein kinase Chk1-like\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]" }, { "name":"138143806 hormonally up-regulated neu tumor-associated kinase homolog\tK08797 HUNK; hormonally upregulated Neu-associated kinase [EC:2.7.11.1]" }, { "name":"138151432 HUNK; (RefSeq) hormonally up-regulated neu tumor-associated kinase\tK08797 HUNK; hormonally upregulated Neu-associated kinase [EC:2.7.11.1]" }, { "name":"138144631 MARK1; (RefSeq) serine\/threonine-protein kinase MARK1 isoform X1\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"138144785 MARK2; (RefSeq) serine\/threonine-protein kinase MARK2 isoform X1\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"138161935 MARK4; (RefSeq) MAP\/microtubule affinity-regulating kinase 4 isoform X1\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"138173727 MARK3; (RefSeq) MAP\/microtubule affinity-regulating kinase 3 isoform X1\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"138158914 MELK; (RefSeq) maternal embryonic leucine zipper kinase isoform X1\tK08799 MELK; maternal embryonic leucine zipper kinase [EC:2.7.11.1]" }, { "name":"138166861 NIM1K; (RefSeq) serine\/threonine-protein kinase NIM1\tK16310 NIM1; serine\/threonine-protein kinase NIM1 [EC:2.7.11.1]" }, { "name":"138151161 NUAK2; (RefSeq) NUAK family SNF1-like kinase 2\tK08800 NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]" }, { "name":"138169841 NUAK1; (RefSeq) NUAK family SNF1-like kinase 1 isoform X1\tK08800 NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]" }, { "name":"138157680 PASK; (RefSeq) PAS domain-containing serine\/threonine-protein kinase isoform X1\tK08801 PASK; PAS domain containing serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"138164938 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]" }, { "name":"138165307 5'-AMP-activated protein kinase catalytic subunit alpha-2-like\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]" }, { "name":"138167395 PRKAA1; (RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]" }, { "name":"138151380 SIK1; (RefSeq) serine\/threonine-protein kinase SIK1\tK19008 SIK1; serine\/threonine-protein kinase SIK1 [EC:2.7.11.1]" }, { "name":"138155189 SIK2; (RefSeq) serine\/threonine-protein kinase SIK2\tK16311 SIK2; serine\/threonine-protein kinase SIK2 [EC:2.7.11.1]" }, { "name":"138155198 SIK3; (RefSeq) serine\/threonine-protein kinase SIK3 isoform X1\tK19009 SIK3; serine\/threonine-protein kinase SIK3 [EC:2.7.11.1]" }, { "name":"138161729 SNRK; (RefSeq) SNF-related serine\/threonine-protein kinase\tK08802 SNRK; SNF related kinase [EC:2.7.11.1]" }, { "name":"138172308 STK11; (RefSeq) serine\/threonine-protein kinase STK11 isoform X1\tK07298 STK11; serine\/threonine-protein kinase 11 [EC:2.7.11.1]" } ] }, { "name":"DAPK family", "children":[ { "name":"138160238 DAPK3; (RefSeq) death-associated protein kinase 3 isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"138161143 DAPK1; (RefSeq) death-associated protein kinase 1 isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"138169152 DAPK2; (RefSeq) death-associated protein kinase 2 isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"138176771 death-associated protein kinase 2-like\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"138147605 STK17B; (RefSeq) serine\/threonine-protein kinase 17B\tK08804 STK17; serine\/threonine kinase 17 [EC:2.7.11.1]" }, { "name":"138158264 STK17A; (RefSeq) serine\/threonine-protein kinase 17A\tK08804 STK17; serine\/threonine kinase 17 [EC:2.7.11.1]" } ] }, { "name":"DCAMKL family", "children":[ { "name":"138155250 DCLK1; (RefSeq) serine\/threonine-protein kinase DCLK1 isoform X1\tK08805 DCLK1_2; doublecortin-like kinase 1\/2 [EC:2.7.11.1]" }, { "name":"138175142 DCLK2; (RefSeq) serine\/threonine-protein kinase DCLK2 isoform X1\tK08805 DCLK1_2; doublecortin-like kinase 1\/2 [EC:2.7.11.1]" }, { "name":"138158480 DCLK3; (RefSeq) serine\/threonine-protein kinase DCLK3\tK17530 DCLK3; doublecortin-like kinase 3 [EC:2.7.11.1]" } ] }, { "name":"MAPKAPK family [OT]", "children":[ { "name":"138151254 MAPKAPK2; (RefSeq) MAP kinase-activated protein kinase 2\tK04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]" }, { "name":"138167047 MAPKAPK3; (RefSeq) MAP kinase-activated protein kinase 3\tK04444 MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]" }, { "name":"138156222 MAPKAPK5; (RefSeq) MAP kinase-activated protein kinase 5 isoform X1\tK04442 MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]" }, { "name":"138149858 MKNK2; (RefSeq) MAP kinase-interacting serine\/threonine-protein kinase 2 isoform X1\tK04372 MKNK; MAP kinase interacting serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"138165010 MAP kinase-interacting serine\/threonine-protein kinase 1 isoform X1\tK04372 MKNK; MAP kinase interacting serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"138165376 MAP kinase-interacting serine\/threonine-protein kinase 1 isoform X1\tK04372 MKNK; MAP kinase interacting serine\/threonine kinase [EC:2.7.11.1]" } ] }, { "name":"MLCK family", "children":[ { "name":"138143712 MYLK; (RefSeq) myosin light chain kinase, smooth muscle isoform X1\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"138150449 MYLK2; (RefSeq) myosin light chain kinase 2, skeletal\/cardiac muscle\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"138157095 MYLK3; (RefSeq) myosin light chain kinase 3\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"138173566 MYLK4; (RefSeq) myosin light chain kinase family member 4 isoform X1\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"138146549 TTN; (RefSeq) titin isoform X1\tK12567 TTN; titin [EC:2.7.11.1]" } ] }, { "name":"PHK family", "children":[ { "name":"138158588 PHKG2; (RefSeq) phosphorylase b kinase gamma catalytic chain, liver\/testis isoform\tK00871 PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]" }, { "name":"138162395 PHKG1; (RefSeq) phosphorylase b kinase gamma catalytic chain, skeletal muscle\/heart isoform\tK00871 PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]" } ] }, { "name":"PIM family [OT]", "children":[ { "name":"138150146 PIM1; (RefSeq) serine\/threonine-protein kinase pim-1\tK04702 PIM1; proto-oncogene serine\/threonine-protein kinase Pim-1 [EC:2.7.11.1]" }, { "name":"138177166 PIM2; (RefSeq) serine\/threonine-protein kinase pim-2\tK08806 PIM2; proto-oncogene serine\/threonine-protein kinase Pim-2 [EC:2.7.11.1]" } ] }, { "name":"PKD family", "children":[ { "name":"138161976 PRKD2; (RefSeq) serine\/threonine-protein kinase D2\tK06070 PKD; protein kinase D [EC:2.7.11.13]" }, { "name":"138175532 PRKD1; (RefSeq) serine\/threonine-protein kinase D1\tK06070 PKD; protein kinase D [EC:2.7.11.13]" }, { "name":"138177424 PRKD3; (RefSeq) serine\/threonine-protein kinase D3\tK06070 PKD; protein kinase D [EC:2.7.11.13]" } ] }, { "name":"PSK family", "children":[ { "name":"138159400 PSKH1; (RefSeq) serine\/threonine-protein kinase H1\tK08808 PSKH; protein serine kinase H [EC:2.7.11.1]" }, { "name":"138173569 PSKH2; (RefSeq) serine\/threonine-protein kinase H2\tK08808 PSKH; protein serine kinase H [EC:2.7.11.1]" } ] }, { "name":"RAD53 family", "children":[ { "name":"138156450 CHEK2; (RefSeq) serine\/threonine-protein kinase Chk2 isoform X1\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]" } ] }, { "name":"Trio family [OT]", "children":[ { "name":"138174315 SPEG; (RefSeq) striated muscle preferentially expressed protein kinase\tK08809 SPEG; striated muscle-specific serine\/threonine protein kinase [EC:2.7.11.1]" }, { "name":"138171849 TRIO; (RefSeq) triple functional domain protein isoform X1\tK08810 TRIO; triple functional domain protein [EC:2.7.11.1]" }, { "name":"138143720 KALRN; (RefSeq) kalirin isoform X1\tK15048 KALRN; kalirin [EC:2.7.11.1]" }, { "name":"138167148 OBSCN; (RefSeq) obscurin\tK17531 OBSCN; obscurin-RhoGEF [EC:2.7.11.1]" } ] }, { "name":"TSSK family", "children":[ { "name":"138146316 TSSK3; (RefSeq) testis-specific serine\/threonine-protein kinase 3\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"138160289 TSSK6; (RefSeq) testis-specific serine\/threonine-protein kinase 6\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"138168935 TSSK4; (RefSeq) LOW QUALITY PROTEIN: testis-specific serine\/threonine-protein kinase 4\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"138171327 testis-specific serine\/threonine-protein kinase 1-like\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"138171328 TSSK2; (RefSeq) testis-specific serine\/threonine-protein kinase 2\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" } ] }, { "name":"CDPK family" }, { "name":"CASK family", "children":[ { "name":"138144419 CASK; (RefSeq) peripheral plasma membrane protein CASK isoform X1\tK06103 CASK; calcium\/calmodulin-dependent serine protein kinase [EC:2.7.11.1]" } ] }, { "name":"Trbl family", "children":[ { "name":"138155941 TRIB1; (RefSeq) tribbles homolog 1\tK08814 TRIB1_2; tribbles homolog 1\/2" }, { "name":"138172950 TRIB2; (RefSeq) tribbles homolog 2\tK08814 TRIB1_2; tribbles homolog 1\/2" }, { "name":"138150437 TRIB3; (RefSeq) tribbles homolog 3\tK19518 TRIB3; tribbles homolog 3" } ] }, { "name":"Other", "children":[ { "name":"138163382 STK33; (RefSeq) serine\/threonine-protein kinase 33 isoform X1\tK08813 STK33; serine\/threonine kinase 33 [EC:2.7.11.1]" }, { "name":"138155636 serine\/threonine-protein kinase 40-like\tK16312 STK40; serine\/threonine-protein kinase 40 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CK1 group", "children":[ { "name":"CK1 family [OT]", "children":[ { "name":"138172786 CSNK1A1; (RefSeq) casein kinase I isoform X1\tK08957 CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]" }, { "name":"138149634 CSNK1G2; (RefSeq) casein kinase I\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"138169146 CSNK1G1; (RefSeq) casein kinase I isoform X1\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"138142902 CSNK1D; (RefSeq) casein kinase I isoform X1\tK08959 CSNK1D; casein kinase 1, delta [EC:2.7.11.1]" }, { "name":"138156682 CSNK1E; (RefSeq) casein kinase I isoform X1\tK08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]" } ] }, { "name":"TTBK family", "children":[ { "name":"138144603 TTBK1; (RefSeq) tau-tubulin kinase 1\tK08815 TTBK; tau tubulin kinase [EC:2.7.11.26]" }, { "name":"138175443 TTBK2; (RefSeq) tau-tubulin kinase 2 isoform X1\tK08815 TTBK; tau tubulin kinase [EC:2.7.11.26]" } ] }, { "name":"VRK family", "children":[ { "name":"138148861 VRK2; (RefSeq) serine\/threonine-protein kinase VRK2 isoform X1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" }, { "name":"138168164 VRK3; (RefSeq) serine\/threonine-protein kinase VRK3 isoform X1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" }, { "name":"138173873 serine\/threonine-protein kinase VRK1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" }, { "name":"138173920 serine\/threonine-protein kinase VRK1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CMGC group", "children":[ { "name":"CDK family", "children":[ { "name":"138154275 cyclin-dependent kinase 11B isoform X1\tK08818 CDC2L; cell division cycle 2-like [EC:2.7.11.22]" }, { "name":"138172180 CDK1; (RefSeq) cyclin-dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]" }, { "name":"138154331 CDK2; (RefSeq) cyclin-dependent kinase 2 isoform X1\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]" }, { "name":"138152495 CDK3; (RefSeq) cyclin-dependent kinase 3 isoform X1\tK02088 CDK3; cyclin-dependent kinase 3 [EC:2.7.11.22]" }, { "name":"138155249 CDK4; (RefSeq) cyclin-dependent kinase 4 isoform X1\tK02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]" }, { "name":"138157944 CDK5; (RefSeq) cyclin-dependent kinase 5 isoform X1\tK02090 CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]" }, { "name":"138159864 CDK6; (RefSeq) cyclin-dependent kinase 6\tK02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]" }, { "name":"138167450 CDK7; (RefSeq) cyclin-dependent kinase 7 isoform X1\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]" }, { "name":"138152959 CDK19; (RefSeq) cyclin-dependent kinase 19 isoform X1\tK02208 CDK8_11; cyclin-dependent kinase 8\/11 [EC:2.7.11.22 2.7.11.23]" }, { "name":"138155243 CDK8; (RefSeq) cyclin-dependent kinase 8 isoform X1\tK02208 CDK8_11; cyclin-dependent kinase 8\/11 [EC:2.7.11.22 2.7.11.23]" }, { "name":"138147189 CDK9; (RefSeq) cyclin-dependent kinase 9\tK02211 CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]" }, { "name":"138159299 CDK10; (RefSeq) cyclin-dependent kinase 10\tK02449 CDK10; cyclin-dependent kinase 10 [EC:2.7.11.22]" }, { "name":"138150826 CDK12; (RefSeq) cyclin-dependent kinase 12 isoform X1\tK08819 CDK12_13; cyclin-dependent kinase 12\/13 [EC:2.7.11.22 2.7.11.23]" }, { "name":"138158516 CDK13; (RefSeq) cyclin-dependent kinase 13\tK08819 CDK12_13; cyclin-dependent kinase 12\/13 [EC:2.7.11.22 2.7.11.23]" }, { "name":"138159884 CDK14; (RefSeq) cyclin-dependent kinase 14 isoform X1\tK08821 CDK14; cyclin-dependent kinase 14 [EC:2.7.11.22]" }, { "name":"138146772 CDK15; (RefSeq) cyclin-dependent kinase 15\tK15594 CDK15; cyclin-dependent kinase 15 [EC:2.7.11.22]" }, { "name":"138177135 CDK16; (RefSeq) cyclin-dependent kinase 16 isoform X1\tK08820 CDK16; cyclin-dependent kinase 16 [EC:2.7.11.22]" }, { "name":"138166712 CDK17; (RefSeq) cyclin-dependent kinase 17\tK15595 CDK17; cyclin-dependent kinase 17 [EC:2.7.11.22]" }, { "name":"138151165 CDK18; (RefSeq) cyclin-dependent kinase 18 isoform X1\tK15596 CDK18; cyclin-dependent kinase 18 [EC:2.7.11.22]" } ] }, { "name":"MAPK family [OT]", "children":[ { "name":"138142603 MAPK3; (RefSeq) mitogen-activated protein kinase 3 isoform X1\tK04371 ERK; mitogen-activated protein kinase 1\/3 [EC:2.7.11.24]" }, { "name":"138171419 MAPK1; (RefSeq) mitogen-activated protein kinase 1\tK04371 ERK; mitogen-activated protein kinase 1\/3 [EC:2.7.11.24]" }, { "name":"138169002 MAPK6; (RefSeq) mitogen-activated protein kinase 6\tK06855 MAPK4_6; mitogen-activated protein kinase 4\/6 [EC:2.7.11.24]" }, { "name":"138174049 MAPK4; (RefSeq) mitogen-activated protein kinase 4 isoform X1\tK06855 MAPK4_6; mitogen-activated protein kinase 4\/6 [EC:2.7.11.24]" }, { "name":"138158890 MAPK7; (RefSeq) mitogen-activated protein kinase 7 isoform X1\tK04464 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]" }, { "name":"138168069 MAPK15; (RefSeq) mitogen-activated protein kinase 15\tK19603 MAPK15; mitogen-activated protein kinase 15 [EC:2.7.11.24]" }, { "name":"138145585 MAPK8; (RefSeq) mitogen-activated protein kinase 8 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"138153422 MAPK9; (RefSeq) mitogen-activated protein kinase 9 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"138165197 MAPK10; (RefSeq) mitogen-activated protein kinase 10 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"138150120 MAPK14; (RefSeq) mitogen-activated protein kinase 14 isoform X1\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"138150124 MAPK13; (RefSeq) mitogen-activated protein kinase 13 isoform X1\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"138173051 MAPK11; (RefSeq) mitogen-activated protein kinase 11\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"138173052 MAPK12; (RefSeq) mitogen-activated protein kinase 12 isoform X1\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"138162554 NLK; (RefSeq) serine\/threonine-protein kinase NLK\tK04468 NLK; nemo like kinase [EC:2.7.11.24]" } ] }, { "name":"GSK family [OT]", "children":[ { "name":"138161893 GSK3A; (RefSeq) LOW QUALITY PROTEIN: glycogen synthase kinase-3 alpha\tK08822 GSK3A; glycogen synthase kinase 3 alpha [EC:2.7.11.26]" }, { "name":"138147461 GSK3B; (RefSeq) glycogen synthase kinase-3 beta isoform X1\tK03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]" } ] }, { "name":"CLK family", "children":[ { "name":"138146676 CLK1; (RefSeq) dual specificity protein kinase CLK1\tK23561 CLK1_4; dual specificity protein kinase CLK1\/4 [EC:2.7.12.1]" }, { "name":"138153529 CLK4; (RefSeq) dual specificity protein kinase CLK4 isoform X1\tK23561 CLK1_4; dual specificity protein kinase CLK1\/4 [EC:2.7.12.1]" }, { "name":"138148486 CLK3; (RefSeq) dual specificity protein kinase CLK3 isoform X1\tK08823 CLK2_3; dual specificity protein kinase CLK2\/3 [EC:2.7.12.1]" } ] }, { "name":"CDKL family", "children":[ { "name":"138164220 CDKL3; (RefSeq) cyclin-dependent kinase-like 3 isoform X1\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"138164232 CDKL2; (RefSeq) cyclin-dependent kinase-like 2\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"138171253 CDKL5; (RefSeq) cyclin-dependent kinase-like 5\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"138176454 CDKL4; (RefSeq) cyclin-dependent kinase-like 4\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" } ] }, { "name":"DYRK family [OT]", "children":[ { "name":"138151491 DYRK1A; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1\tK08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]" }, { "name":"138154075 DYRK1B; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1\tK08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]" }, { "name":"138151198 DYRK3; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"138155779 DYRK2; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"138171871 DYRK4; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 4\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"138154043 HIPK4; (RefSeq) homeodomain-interacting protein kinase 4\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"138160660 HIPK2; (RefSeq) homeodomain-interacting protein kinase 2 isoform X1\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"138162836 HIPK1; (RefSeq) homeodomain-interacting protein kinase 1 isoform X1\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"138163810 HIPK3; (RefSeq) homeodomain-interacting protein kinase 3 isoform X1\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"138173534 PRP4K; (RefSeq) serine\/threonine-protein kinase PRP4 homolog\tK08827 PRPF4B; serine\/threonine-protein kinase PRP4 [EC:2.7.11.1]" } ] }, { "name":"RCK family [OT]", "children":[ { "name":"138148002 CILK1; (RefSeq) serine\/threonine-protein kinase ICK isoform X1\tK08828 ICK; intestinal cell (MAK-like) kinase [EC:2.7.11.22]" }, { "name":"138173490 MAK; (RefSeq) serine\/threonine-protein kinase MAK isoform X1\tK08829 MAK; male germ cell-associated kinase [EC:2.7.11.22]" }, { "name":"138173708 MOK; (RefSeq) MAPK\/MAK\/MRK overlapping kinase isoform X1\tK08830 RAGE; renal tumor antigen [EC:2.7.11.22]" } ] }, { "name":"SRPK family [OT]", "children":[ { "name":"138150119 SRPK1; (RefSeq) SRSF protein kinase 1 isoform X1\tK15409 SRPK1; serine\/threonine-protein kinase SRPK1 [EC:2.7.11.1]" }, { "name":"138175909 SRSF protein kinase 2 isoform X1\tK08831 SRPK2; serine\/threonine-protein kinase SRPK2 [EC:2.7.11.1]" }, { "name":"138176059 SRSF protein kinase 2 isoform X1\tK08831 SRPK2; serine\/threonine-protein kinase SRPK2 [EC:2.7.11.1]" }, { "name":"138177323 SRPK3; (RefSeq) SRSF protein kinase 3 isoform X1\tK08832 SRPK3; serine\/threonine-protein kinase SRPK3 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: STE group", "children":[ { "name":"STE7 family", "children":[ { "name":"138169106 MAP2K1; (RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1\tK04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]" }, { "name":"138160244 MAP2K2; (RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1\tK04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]" }, { "name":"138158622 MAP2K3; (RefSeq) dual specificity mitogen-activated protein kinase kinase 3 isoform X1\tK04432 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]" }, { "name":"138152711 MAP2K4; (RefSeq) dual specificity mitogen-activated protein kinase kinase 4 isoform X1\tK04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]" }, { "name":"138168312 MAP2K5; (RefSeq) dual specificity mitogen-activated protein kinase kinase 5\tK04463 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]" }, { "name":"138152587 MAP2K6; (RefSeq) dual specificity mitogen-activated protein kinase kinase 6 isoform X1\tK04433 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]" }, { "name":"138166847 MAP2K7; (RefSeq) dual specificity mitogen-activated protein kinase kinase 7 isoform X1\tK04431 MAP2K7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]" } ] }, { "name":"STE20 family", "children":[ { "name":"138154073 MAP4K1; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 1\tK04408 MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]" }, { "name":"138144846 MAP4K2; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 2\tK04414 MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]" }, { "name":"138176453 mitogen-activated protein kinase kinase kinase kinase 3 isoform X1\tK04406 MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]" }, { "name":"138171186 MAP4K4; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 4 isoform X1\tK04407 MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]" }, { "name":"138156849 MAP4K5; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 5\tK08833 MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5 [EC:2.7.11.1]" }, { "name":"138142253 MINK1; (RefSeq) misshapen-like kinase 1\tK04413 MINK; misshapen\/NIK-related kinase [EC:2.7.11.1]" }, { "name":"138157777 TNIK; (RefSeq) TRAF2 and NCK-interacting protein kinase isoform X1\tK08840 TNIK; TRAF2 and NCK interacting kinase [EC:2.7.11.1]" }, { "name":"138159777 MYO3A; (RefSeq) myosin-IIIa\tK08834 MYO3; myosin III [EC:2.7.11.1]" }, { "name":"138155434 STK39; (RefSeq) STE20\/SPS1-related proline-alanine-rich protein kinase isoform X1\tK08835 OXSR1; serine\/threonine-protein kinase OSR1\/STK39 [EC:2.7.11.1]" }, { "name":"138158224 OXSR1; (RefSeq) serine\/threonine-protein kinase OSR1 isoform X1\tK08835 OXSR1; serine\/threonine-protein kinase OSR1\/STK39 [EC:2.7.11.1]" }, { "name":"138148300 PAK1; (RefSeq) serine\/threonine-protein kinase PAK 1 isoform X1\tK04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]" }, { "name":"138143756 PAK2; (RefSeq) serine\/threonine-protein kinase PAK 2\tK04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]" }, { "name":"138143912 PAK3; (RefSeq) serine\/threonine-protein kinase PAK 3 isoform X1\tK05733 PAK3; p21-activated kinase 3 [EC:2.7.11.1]" }, { "name":"138154089 PAK4; (RefSeq) serine\/threonine-protein kinase PAK 4 isoform X1\tK05734 PAK4; p21-activated kinase 4 [EC:2.7.11.1]" }, { "name":"138151859 PAK5; (RefSeq) serine\/threonine-protein kinase PAK 5 isoform X1\tK05736 PAK5; p21-activated kinase 5 [EC:2.7.11.1]" }, { "name":"138175255 PAK6; (RefSeq) serine\/threonine-protein kinase PAK 6\tK05735 PAK6; p21-activated kinase 6 [EC:2.7.11.1]" }, { "name":"138169442 SLK; (RefSeq) STE20-like serine\/threonine-protein kinase isoform X1\tK08836 SLK; STE20-like kinase [EC:2.7.11.1]" }, { "name":"138151998 LOW QUALITY PROTEIN: STE20-like serine\/threonine-protein kinase\tK08837 STK10; serine\/threonine kinase 10 [EC:2.7.11.1]" }, { "name":"138172650 STK10; (RefSeq) serine\/threonine-protein kinase 10 isoform X1\tK08837 STK10; serine\/threonine kinase 10 [EC:2.7.11.1]" }, { "name":"138152464 STRADA; (RefSeq) STE20-related kinase adapter protein alpha isoform X1\tK08271 STRADA; STE20-related kinase adapter protein alpha" }, { "name":"138146690 STRADB; (RefSeq) STE20-related kinase adapter protein beta isoform X1\tK17532 STRADB; STE20-related kinase adapter protein beta" }, { "name":"138155725 STK3; (RefSeq) serine\/threonine-protein kinase 3 isoform X1\tK04412 STK3; serine\/threonine kinase 3" }, { "name":"138149024 STK4; (RefSeq) serine\/threonine-protein kinase 4 isoform X1\tK04411 STK4; serine\/threonine kinase 4" }, { "name":"138143015 STK24; (RefSeq) serine\/threonine-protein kinase 24 isoform X1\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"138150667 STK26; (RefSeq) serine\/threonine-protein kinase 26 isoform X1\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"138157677 STK25; (RefSeq) serine\/threonine-protein kinase 25 isoform X1\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"138142478 TAOK2; (RefSeq) serine\/threonine-protein kinase TAO2 isoform X1\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" }, { "name":"138156364 TAOK3; (RefSeq) serine\/threonine-protein kinase TAO3 isoform X1\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" }, { "name":"138162511 TAOK1; (RefSeq) LOW QUALITY PROTEIN: serine\/threonine-protein kinase TAO1\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" } ] }, { "name":"STE11 family", "children":[ { "name":"138167517 MAP3K1; (RefSeq) mitogen-activated protein kinase kinase kinase 1 isoform X1\tK04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]" }, { "name":"138145233 MAP3K2; (RefSeq) mitogen-activated protein kinase kinase kinase 2\tK04420 MAP3K2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]" }, { "name":"138152457 MAP3K3; (RefSeq) mitogen-activated protein kinase kinase kinase 3 isoform X1\tK04421 MAP3K3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]" }, { "name":"138147798 MAP3K4; (RefSeq) mitogen-activated protein kinase kinase kinase 4 isoform X1\tK04428 MAP3K4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]" }, { "name":"138153106 MAP3K5; (RefSeq) mitogen-activated protein kinase kinase kinase 5\tK04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]" }, { "name":"138153991 MAP3K6; (RefSeq) mitogen-activated protein kinase kinase kinase 6 isoform X1\tK04425 MAP3K6; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]" }, { "name":"138142392 MAP3K15; (RefSeq) mitogen-activated protein kinase kinase kinase 15\tK13986 MAP3K15; mitogen-activated protein kinase kinase kinase 15 [EC:2.7.11.25]" }, { "name":"138146112 MAP3K19; (RefSeq) mitogen-activated protein kinase kinase kinase 19\tK17533 MAP3K19; mitogen-activated protein kinase kinase kinase 19 [EC:2.7.11.25]" } ] }, { "name":"Other", "children":[ { "name":"138159977 MAP3K8; (RefSeq) mitogen-activated protein kinase kinase kinase 8\tK04415 MAP3K8; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]" }, { "name":"138152424 MAP3K14; (RefSeq) mitogen-activated protein kinase kinase kinase 14\tK04466 MAP3K14; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]" } ] } ] }, { "name":"Serine\/threonine kinases: TKL group", "children":[ { "name":"IRAK family", "children":[ { "name":"138177309 IRAK1; (RefSeq) interleukin-1 receptor-associated kinase 1 isoform X1\tK04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]" }, { "name":"138158070 IRAK2; (RefSeq) interleukin-1 receptor-associated kinase-like 2 isoform X1\tK04731 IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]" }, { "name":"138155712 IRAK3; (RefSeq) interleukin-1 receptor-associated kinase 3 isoform X1\tK04732 IRAK3; interleukin-1 receptor-associated kinase 3 [EC:2.7.11.1]" }, { "name":"138165861 IRAK4; (RefSeq) interleukin-1 receptor-associated kinase 4\tK04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]" } ] }, { "name":"LISK family [OT]", "children":[ { "name":"138162386 LIMK1; (RefSeq) LIM domain kinase 1\tK05743 LIMK1; LIM domain kinase 1 [EC:2.7.11.1]" }, { "name":"138156366 LIMK2; (RefSeq) LIM domain kinase 2 isoform X1\tK05744 LIMK2; LIM domain kinase 2 [EC:2.7.11.1]" }, { "name":"138161856 TESK1; (RefSeq) dual specificity testis-specific protein kinase 1\tK08841 TESK1; testis-specific kinase 1 [EC:2.7.12.1]" }, { "name":"138165031 dual specificity testis-specific protein kinase 2-like\tK08842 TESK2; testis-specific kinase 2 [EC:2.7.12.1]" }, { "name":"138165398 dual specificity testis-specific protein kinase 2-like\tK08842 TESK2; testis-specific kinase 2 [EC:2.7.12.1]" } ] }, { "name":"LRRK family", "children":[ { "name":"138168325 LRRK1; (RefSeq) leucine-rich repeat serine\/threonine-protein kinase 1\tK08843 LRRK1; leucine-rich repeat kinase 1 [EC:2.7.11.1]" }, { "name":"138169865 LRRK2; (RefSeq) leucine-rich repeat serine\/threonine-protein kinase 2 isoform X1\tK08844 LRRK2; leucine-rich repeat kinase 2 [EC:2.7.11.1]" } ] }, { "name":"MLK family", "children":[ { "name":"138164170 MAP3K9; (RefSeq) mitogen-activated protein kinase kinase kinase 9\tK04417 MAP3K9; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]" }, { "name":"138153996 MAP3K10; (RefSeq) mitogen-activated protein kinase kinase kinase 10\tK04418 MAP3K10; mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]" }, { "name":"138144854 MAP3K11; (RefSeq) mitogen-activated protein kinase kinase kinase 11 isoform X1\tK04419 MAP3K11; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]" }, { "name":"138143622 MAP3K21; (RefSeq) mitogen-activated protein kinase kinase kinase 21 isoform X1\tK17534 MLK4; mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]" }, { "name":"138146501 MAP3K20; (RefSeq) mitogen-activated protein kinase kinase kinase 20 isoform X1\tK04424 ZAK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]" }, { "name":"138171651 MAP3K12; (RefSeq) mitogen-activated protein kinase kinase kinase 12\tK04423 MAP3K12; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]" }, { "name":"138162311 MAP3K13; (RefSeq) mitogen-activated protein kinase kinase kinase 13\tK04422 MAP3K13; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]" }, { "name":"138164769 serine\/threonine-protein kinase TNNI3K-like\tK17535 TNNI3K; serine\/threonine-protein kinase TNNI3K [EC:2.7.11.1]" }, { "name":"138165142 serine\/threonine-protein kinase TNNI3K\tK17535 TNNI3K; serine\/threonine-protein kinase TNNI3K [EC:2.7.11.1]" }, { "name":"138176926 ILK; (RefSeq) integrin-linked protein kinase isoform X1\tK06272 ILK; integrin-linked kinase [EC:2.7.11.1]" } ] }, { "name":"RAF family [OT]", "children":[ { "name":"138160673 BRAF; (RefSeq) serine\/threonine-protein kinase B-raf isoform X1\tK04365 BRAF; B-Raf proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"138158036 RAF1; (RefSeq) RAF proto-oncogene serine\/threonine-protein kinase\tK04366 RAF1; RAF proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"138162556 KSR1; (RefSeq) kinase suppressor of Ras 1 isoform X1\tK14958 KSR1; kinase suppressor of Ras 1" }, { "name":"138156188 KSR2; (RefSeq) kinase suppressor of Ras 2\tK18529 KSR2; kinase suppressor of Ras 2 [EC:2.7.11.1]" } ] }, { "name":"RIPK family [OT]", "children":[ { "name":"138173542 RIPK1; (RefSeq) receptor-interacting serine\/threonine-protein kinase 1 isoform X1\tK02861 RIPK1; receptor-interacting serine\/threonine-protein kinase 1 [EC:2.7.11.1]" }, { "name":"138160142 RIPK2; (RefSeq) receptor-interacting serine\/threonine-protein kinase 2 isoform X1\tK08846 RIPK2; receptor-interacting serine\/threonine-protein kinase 2 [EC:2.7.11.1]" }, { "name":"138151417 RIPK4; (RefSeq) receptor-interacting serine\/threonine-protein kinase 4\tK08848 RIPK4; receptor-interacting serine\/threonine-protein kinase 4 [EC:2.7.11.1]" }, { "name":"138155239 ANKK1; (RefSeq) ankyrin repeat and protein kinase domain-containing protein 1\tK16289 ANKK1; ankyrin repeat and protein kinase domain-containing protein 1 [EC:2.7.11.1]" } ] }, { "name":"Other" } ] }, { "name":"Serine\/threonine kinases: Other", "children":[ { "name":"RGC family [OT]", "children":[ { "name":"138153804 NPR1; (RefSeq) atrial natriuretic peptide receptor 1\tK12323 NPR1; atrial natriuretic peptide receptor 1 [EC:4.6.1.2]" }, { "name":"138162055 NPR2; (RefSeq) atrial natriuretic peptide receptor 2 isoform X1\tK12324 NPR2; atrial natriuretic peptide receptor 2 [EC:4.6.1.2]" }, { "name":"138171890 GUCY2C; (RefSeq) guanylyl cyclase C\tK12320 GUCY2C; heat-stable enterotoxin receptor [EC:4.6.1.2]" }, { "name":"138148218 guanylate cyclase D-like\tK12321 GUCY2D_E; guanylate cyclase 2D\/E [EC:4.6.1.2]" }, { "name":"138174024 GUCY2D; (RefSeq) retinal guanylyl cyclase 1\tK12321 GUCY2D_E; guanylate cyclase 2D\/E [EC:4.6.1.2]" } ] }, { "name":"BUB family", "children":[ { "name":"138151968 BUB1; (RefSeq) mitotic checkpoint serine\/threonine-protein kinase BUB1\tK02178 BUB1; checkpoint serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"138175381 BUB1B; (RefSeq) mitotic checkpoint serine\/threonine-protein kinase BUB1 beta\tK06637 BUB1B; mitotic checkpoint serine\/threonine-protein kinase BUB1 beta [EC:2.7.11.1]" } ] }, { "name":"Bud32 family", "children":[ { "name":"138149366 TP53RK; (RefSeq) EKC\/KEOPS complex subunit TP53RK\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]" } ] }, { "name":"CAMKK family", "children":[ { "name":"138157912 CAMKK1; (RefSeq) calcium\/calmodulin-dependent protein kinase kinase 1\tK00908 CAMKK1; calcium\/calmodulin-dependent protein kinase kinase 1 [EC:2.7.11.17]" }, { "name":"138156483 CAMKK2; (RefSeq) calcium\/calmodulin-dependent protein kinase kinase 2 isoform X1\tK07359 CAMKK2; calcium\/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]" } ] }, { "name":"CDC7 family", "children":[ { "name":"138165090 cell division cycle 7-related protein kinase-like isoform X1\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]" }, { "name":"138165481 cell division cycle 7-related protein kinase-like isoform X1\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]" } ] }, { "name":"CK2 family", "children":[ { "name":"138150433 CSNK2A1; (RefSeq) casein kinase II subunit alpha\tK03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]" }, { "name":"138160821 CSNK2A2; (RefSeq) casein kinase II subunit alpha' isoform X1\tK03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]" } ] }, { "name":"Haspin family", "children":[ { "name":"138157612 HASPIN; (RefSeq) serine\/threonine-protein kinase haspin\tK16315 GSG2; serine\/threonine-protein kinase haspin [EC:2.7.11.1]" } ] }, { "name":"IKK family [OT]", "children":[ { "name":"138148571 CHUK; (RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1\tK04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]" }, { "name":"138152084 IKBKB; (RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1\tK07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]" }, { "name":"138142668 IKBKG; (RefSeq) NF-kappa-B essential modulator isoform X1\tK07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma" }, { "name":"138151195 IKBKE; (RefSeq) LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon\tK07211 IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]" }, { "name":"138155514 TBK1; (RefSeq) serine\/threonine-protein kinase TBK1 isoform X1\tK05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]" } ] }, { "name":"IRE family", "children":[ { "name":"138152469 ERN1; (RefSeq) serine\/threonine-protein kinase\/endoribonuclease IRE1 isoform X1\tK08852 ERN1; serine\/threonine-protein kinase\/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]" }, { "name":"138162288 ERN2; (RefSeq) serine\/threonine-protein kinase\/endoribonuclease IRE2\tK11715 ERN2; serine\/threonine-protein kinase\/endoribonuclease IRE2 [EC:2.7.11.1 3.1.26.-]" } ] }, { "name":"MOS family", "children":[ { "name":"138170119 MOS; (RefSeq) proto-oncogene serine\/threonine-protein kinase mos\tK04367 MOS; proto-oncogene serine\/threonine-protein kinase mos [EC:2.7.11.1]" } ] }, { "name":"NAK family [OT]", "children":[ { "name":"138146814 AAK1; (RefSeq) AP2-associated protein kinase 1 isoform X1\tK08853 AAK; AP2-associated kinase [EC:2.7.11.1]" }, { "name":"138164866 BMP2K; (RefSeq) BMP-2-inducible protein kinase isoform X1\tK08854 BMP2K; BMP2 inducible kinase [EC:2.7.11.1]" }, { "name":"138149477 GAK; (RefSeq) cyclin-G-associated kinase isoform X1\tK08855 GAK; cyclin G-associated kinase [EC:2.7.11.1]" }, { "name":"138174308 STK16; (RefSeq) serine\/threonine-protein kinase 16 isoform X1\tK08856 STK16; serine\/threonine kinase 16 [EC:2.7.11.1]" } ] }, { "name":"NEK family", "children":[ { "name":"138143359 NEK5; (RefSeq) serine\/threonine-protein kinase Nek5\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"138166997 NEK4; (RefSeq) serine\/threonine-protein kinase Nek4 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"138168104 NEK1; (RefSeq) serine\/threonine-protein kinase Nek1 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"138177549 NEK2; (RefSeq) serine\/threonine-protein kinase Nek2\tK20872 NEK2; serine\/threonine-protein kinase Nek2 [EC:2.7.11.1]" }, { "name":"138143398 NEK3; (RefSeq) serine\/threonine-protein kinase Nek3\tK20873 NEK3; serine\/threonine-protein kinase Nek3 [EC:2.7.11.1]" }, { "name":"138157203 NEK6; (RefSeq) serine\/threonine-protein kinase Nek6 isoform X1\tK20875 NEK6; serine\/threonine-protein kinase Nek6 [EC:2.7.11.34]" }, { "name":"138151049 NEK7; (RefSeq) serine\/threonine-protein kinase Nek7 isoform X1\tK20876 NEK7; serine\/threonine-protein kinase Nek7 [EC:2.7.11.34]" }, { "name":"138162528 NEK8; (RefSeq) serine\/threonine-protein kinase Nek8\tK20877 NEK8; serine\/threonine-protein kinase Nek8 [EC:2.7.11.1]" }, { "name":"138164427 NEK9; (RefSeq) serine\/threonine-protein kinase Nek9\tK20878 NEK9; serine\/threonine-protein kinase Nek9 [EC:2.7.11.38]" }, { "name":"138161700 NEK10; (RefSeq) serine\/threonine-protein kinase Nek10 isoform X1\tK20879 NEK10; serine\/threonine-protein kinase Nek10 [EC:2.7.11.1]" }, { "name":"138161638 NEK11; (RefSeq) serine\/threonine-protein kinase Nek11\tK20880 NEK11; serine\/threonine-protein kinase Nek11 [EC:2.7.11.1]" } ] }, { "name":"NKF1 family", "children":[ { "name":"138142967 SBK1; (RefSeq) serine\/threonine-protein kinase SBK1\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" }, { "name":"138168253 SBK2; (RefSeq) serine\/threonine-protein kinase SBK2 isoform X1\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" }, { "name":"138168254 SBK3; (RefSeq) uncharacterized serine\/threonine-protein kinase SBK3\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" } ] }, { "name":"NKF2 family", "children":[ { "name":"138154012 PINK1; (RefSeq) serine\/threonine-protein kinase PINK1, mitochondrial\tK05688 PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]" } ] }, { "name":"NKF3 family", "children":[ { "name":"138174633 PRAG1; (RefSeq) inactive tyrosine-protein kinase PRAG1\tK17537 SGK223; tyrosine-protein kinase SgK223 [EC:2.7.10.2]" }, { "name":"138148631 PEAK1; (RefSeq) inactive tyrosine-protein kinase PEAK1\tK17538 PEAK1; pseudopodium-enriched atypical kinase 1 [EC:2.7.10.2]" } ] }, { "name":"NKF4 family", "children":[ { "name":"138141831 STK35; (RefSeq) serine\/threonine-protein kinase 35 isoform X1\tK08859 STK35; serine\/threonine kinase 35 [EC:2.7.11.1]" }, { "name":"138154248 PDIK1L; (RefSeq) serine\/threonine-protein kinase PDIK1L isoform X1\tK17539 PDIK1L; serine\/threonine-protein kinase PDIK1L [EC:2.7.11.1]" } ] }, { "name":"NKF5 family", "children":[ { "name":"138153764 TEX14; (RefSeq) inactive serine\/threonine-protein kinase TEX14\tK17540 TEX14; inactive serine\/threonine-protein kinase TEX14" } ] }, { "name":"NRBP family", "children":[ { "name":"138149144 NRBP1; (RefSeq) nuclear receptor-binding protein\tK08875 NRBP; nuclear receptor-binding protein" }, { "name":"138168067 NRBP2; (RefSeq) nuclear receptor-binding protein 2\tK08875 NRBP; nuclear receptor-binding protein" } ] }, { "name":"PEK family [OT]", "children":[ { "name":"138158733 EIF2AK1; (RefSeq) eukaryotic translation initiation factor 2-alpha kinase 1\tK16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]" }, { "name":"138149196 EIF2AK2; (RefSeq) interferon-induced, double-stranded RNA-activated protein kinase isoform X1\tK16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]" }, { "name":"138171525 EIF2AK3; (RefSeq) eukaryotic translation initiation factor 2-alpha kinase 3\tK08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]" }, { "name":"138175376 EIF2AK4; (RefSeq) eIF-2-alpha kinase GCN2 isoform X1\tK16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]" } ] }, { "name":"PLK family [OT]", "children":[ { "name":"138162297 PLK1; (RefSeq) serine\/threonine-protein kinase PLK1\tK06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]" }, { "name":"138167508 PLK2; (RefSeq) serine\/threonine-protein kinase PLK2\tK08861 PLK2; polo-like kinase 2 [EC:2.7.11.21]" }, { "name":"138165046 serine\/threonine-protein kinase PLK3-like\tK08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]" }, { "name":"138165411 serine\/threonine-protein kinase PLK3-like\tK08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]" }, { "name":"138163701 PLK4; (RefSeq) serine\/threonine-protein kinase PLK4 isoform X1\tK08863 PLK4; polo-like kinase 4 [EC:2.7.11.21]" } ] }, { "name":"SCY1 family [OT]", "children":[ { "name":"138144830 SCYL1; (RefSeq) N-terminal kinase-like protein isoform X1\tK08876 SCYL1; SCY1-like protein 1" }, { "name":"138166724 SCYL2; (RefSeq) SCY1-like protein 2 isoform X1\tK17541 SCYL2; SCY1-like protein 2" }, { "name":"138166258 SCYL3; (RefSeq) protein-associating with the carboxyl-terminal domain of ezrin isoform X1\tK17542 SCYL3; SCY1-like protein 3" } ] }, { "name":"Slob family", "children":[ { "name":"138158172 PXK; (RefSeq) PX domain-containing protein kinase-like protein isoform X1\tK17543 PXK; PX domain-containing protein kinase-like protein" } ] }, { "name":"TBCK family", "children":[ { "name":"138166336 TBCK; (RefSeq) TBC domain-containing protein kinase-like protein isoform X1\tK17544 TBCK; TBC domain-containing protein kinase-like protein" } ] }, { "name":"TLK family", "children":[ { "name":"138152447 TLK2; (RefSeq) serine\/threonine-protein kinase tousled-like 2 isoform X1\tK08864 TLK; tousled-like kinase [EC:2.7.11.1]" }, { "name":"138154708 TLK1; (RefSeq) serine\/threonine-protein kinase tousled-like 1 isoform X1\tK08864 TLK; tousled-like kinase [EC:2.7.11.1]" } ] }, { "name":"TOPK family", "children":[ { "name":"138149077 PBK; (RefSeq) lymphokine-activated killer T-cell-originated protein kinase\tK08865 PBK; PDZ-binding kinase [EC:2.7.12.2]" } ] }, { "name":"TTK family", "children":[ { "name":"138145345 TTK; (RefSeq) dual specificity protein kinase TTK isoform X1\tK08866 TTK; serine\/threonine-protein kinase TTK\/MPS1 [EC:2.7.12.1]" } ] }, { "name":"ULK family [OT]", "children":[ { "name":"138151627 STK36; (RefSeq) serine\/threonine-protein kinase 36\tK06228 FU; fused [EC:2.7.11.1]" }, { "name":"138159228 serine\/threonine-protein kinase ULK1-like isoform X1\tK21357 ULK1; serine\/threonine-protein kinase ULK1 [EC:2.7.11.1]" }, { "name":"138176007 serine\/threonine-protein kinase ULK1-like isoform X4\tK21357 ULK1; serine\/threonine-protein kinase ULK1 [EC:2.7.11.1]" }, { "name":"138162441 ULK2; (RefSeq) serine\/threonine-protein kinase ULK2 isoform X1\tK08269 ULK2; serine\/threonine-protein kinase ULK2 [EC:2.7.11.1]" }, { "name":"138148478 ULK3; (RefSeq) serine\/threonine-protein kinase ULK3 isoform X1\tK21358 ULK3; serine\/threonine-protein kinase ULK3 [EC:2.7.11.1]" }, { "name":"138161589 ULK4; (RefSeq) serine\/threonine-protein kinase ULK4 isoform X1\tK17545 ULK4; serine\/threonine-protein kinase ULK4 [EC:2.7.11.1]" } ] }, { "name":"VPS15 family", "children":[ { "name":"138161644 PIK3R4; (RefSeq) phosphoinositide 3-kinase regulatory subunit 4\tK08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]" } ] }, { "name":"WEE family", "children":[ { "name":"138176495 PKMYT1; (RefSeq) membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase\tK06633 PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]" }, { "name":"138160386 WEE2; (RefSeq) wee1-like protein kinase 2\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]" }, { "name":"138163735 WEE1; (RefSeq) wee1-like protein kinase\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]" } ] }, { "name":"Wnk family", "children":[ { "name":"138145934 WNK4; (RefSeq) serine\/threonine-protein kinase WNK4 isoform X1\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" }, { "name":"138157948 WNK2; (RefSeq) serine\/threonine-protein kinase WNK2 isoform X1\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" }, { "name":"138165928 WNK1; (RefSeq) serine\/threonine-protein kinase WNK1 isoform X1\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" }, { "name":"138177190 WNK3; (RefSeq) serine\/threonine-protein kinase WNK3\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" } ] }, { "name":"ABC1 family", "children":[ { "name":"138146978 COQ8A; (RefSeq) atypical kinase COQ8A, mitochondrial isoform X1\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"138154508 COQ8B; (RefSeq) atypical kinase COQ8B, mitochondrial\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"138160674 ADCK2; (RefSeq) uncharacterized aarF domain-containing protein kinase 2 isoform X1\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"138164462 ADCK1; (RefSeq) aarF domain-containing protein kinase 1 isoform X1\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"138168035 ADCK5; (RefSeq) uncharacterized aarF domain-containing protein kinase 5 isoform X1\tK08869 ADCK; aarF domain-containing kinase" } ] }, { "name":"Alpha family [OT]", "children":[ { "name":"138166843 ALPK1; (RefSeq) alpha-protein kinase 1 isoform X1\tK08868 ALPK; alpha-kinase" }, { "name":"138169352 ALPK3; (RefSeq) alpha-protein kinase 3 isoform X1\tK08868 ALPK; alpha-kinase" }, { "name":"138172292 LOW QUALITY PROTEIN: alpha-protein kinase 2-like\tK08868 ALPK; alpha-kinase" }, { "name":"138173541 LOW QUALITY PROTEIN: alpha-protein kinase 2-like\tK08868 ALPK; alpha-kinase" }, { "name":"138158555 TRPM6; (RefSeq) transient receptor potential cation channel subfamily M member 6\tK04981 TRPM6; transient receptor potential cation channel subfamily M member 6 [EC:2.7.11.1]" }, { "name":"138168986 TRPM7; (RefSeq) transient receptor potential cation channel subfamily M member 7\tK04982 TRPM7; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1]" }, { "name":"138158748 EEF2K; (RefSeq) eukaryotic elongation factor 2 kinase isoform X1\tK08292 EEF2K; elongation factor 2 kinase [EC:2.7.11.20]" } ] }, { "name":"BCR family", "children":[ { "name":"138167718 BCR; (RefSeq) LOW QUALITY PROTEIN: breakpoint cluster region protein\tK08878 BCR1; breakpoint cluster region protein [EC:2.7.11.1]" } ] }, { "name":"BRD family [OT]", "children":[ { "name":"138150048 BRD2; (RefSeq) bromodomain-containing protein 2 isoform X1\tK08871 BRD2; bromodomain-containing protein 2" }, { "name":"138147063 BRD3; (RefSeq) bromodomain-containing protein 3\tK11721 BRD3; bromodomain-containing protein 3" }, { "name":"138160305 BRD4; (RefSeq) bromodomain-containing protein 4 isoform X1\tK11722 BRD4; bromodomain-containing protein 4" }, { "name":"138164765 bromodomain testis-specific protein-like\tK11724 BRDT; bromodomain testis-specific protein" }, { "name":"138165469 bromodomain testis-specific protein-like\tK11724 BRDT; bromodomain testis-specific protein" } ] }, { "name":"FAST family" }, { "name":"G11 family", "children":[ { "name":"138150208 STK19; (RefSeq) inactive serine\/threonine-protein kinase 19\tK08880 STK19; serine\/threonine kinase 19 [EC:2.7.11.1]" } ] }, { "name":"H11 family", "children":[ { "name":"138156447 HSPB8; (RefSeq) heat shock protein beta-8\tK08879 HSPB8; heat shock protein beta-8" } ] }, { "name":"PDHK family [OT]", "children":[ { "name":"138155224 PDK1; (RefSeq) pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1\tK12077 PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]" }, { "name":"138143213 PDK2; (RefSeq) pyruvate dehydrogenase kinase, isozyme 2\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" }, { "name":"138144314 PDK3; (RefSeq) pyruvate dehydrogenase kinase, isozyme 3 isoform X1\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" }, { "name":"138166029 PDK4; (RefSeq) pyruvate dehydrogenase kinase, isozyme 4\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" }, { "name":"138158568 BCKDK; (RefSeq) branched-chain alpha-ketoacid dehydrogenase kinase\tK00905 BCKDK; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase [EC:2.7.11.4]" } ] }, { "name":"PIKK family [OT]", "children":[ { "name":"138155317 ATM; (RefSeq) serine-protein kinase ATM\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]" }, { "name":"138174378 ATR; (RefSeq) serine\/threonine-protein kinase ATR isoform X1\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]" }, { "name":"138154328 MTOR; (RefSeq) serine\/threonine-protein kinase mTOR\tK07203 MTOR; serine\/threonine-protein kinase mTOR [EC:2.7.11.1]" }, { "name":"138170510 PRKDC; (RefSeq) DNA-dependent protein kinase catalytic subunit isoform X1\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]" }, { "name":"138167318 SMG1; (RefSeq) serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"138158723 TRRAP; (RefSeq) transformation\/transcription domain-associated protein isoform X1\tK08874 TRRAP; transformation\/transcription domain-associated protein" } ] }, { "name":"RIO family [OT]", "children":[ { "name":"138173514 RIOK1; (RefSeq) serine\/threonine-protein kinase RIO1\tK07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]" }, { "name":"138158863 RIOK2; (RefSeq) serine\/threonine-protein kinase RIO2\tK07179 RIOK2; RIO kinase 2 [EC:2.7.11.1]" }, { "name":"138170449 RIOK3; (RefSeq) serine\/threonine-protein kinase RIO3\tK08872 RIOK3; RIO kinase 3 [EC:2.7.11.1]" } ] }, { "name":"TAF1 family", "children":[ { "name":"138141666 TAF1; (RefSeq) transcription initiation factor TFIID subunit 1 isoform X1\tK03125 TAF1; transcription initiation factor TFIID subunit 1 [EC:2.3.1.48 2.7.11.1]" }, { "name":"138161395 CUNH19orf84; (RefSeq) uncharacterized protein C19orf84 homolog\tK03125 TAF1; transcription initiation factor TFIID subunit 1 [EC:2.3.1.48 2.7.11.1]" }, { "name":"138159504 CIITA; (RefSeq) MHC class II transactivator isoform X1\tK08060 CIITA; MHC class II transactivator [EC:2.7.11.1]" } ] }, { "name":"TIF1 family [OT]", "children":[ { "name":"138160643 TRIM24; (RefSeq) transcription intermediary factor 1-alpha isoform X1\tK08881 TRIM24; tripartite motif-containing protein 24 [EC:2.3.2.27]" }, { "name":"138172938 TRIM28; (RefSeq) transcription intermediary factor 1-beta\tK08882 TRIM28; tripartite motif-containing protein 28 [EC:2.3.2.27]" }, { "name":"138162831 TRIM33; (RefSeq) E3 ubiquitin-protein ligase TRIM33 isoform X1\tK08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]" } ] }, { "name":"Other", "children":[ { "name":"138166202 UHMK1; (RefSeq) serine\/threonine-protein kinase Kist isoform X1\tK08877 UHMK1; serine\/threonine-protein kinase Kist [EC:2.7.11.1]" }, { "name":"138167043 DCAF1; (RefSeq) DDB1- and CUL4-associated factor 1 isoform X1\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"138152072 POMK; (RefSeq) protein O-mannose kinase\tK17547 SGK196; glycoprotein-mannosyl O6-kinase [EC:2.7.1.183]" }, { "name":"138151153 DSTYK; (RefSeq) dual serine\/threonine and tyrosine protein kinase isoform X1\tK16288 DSTYK; dual serine\/threonine and tyrosine protein kinase [EC:2.7.12.1]" }, { "name":"138147073 STKLD1; (RefSeq) serine\/threonine kinase-like domain-containing protein STKLD1\tK17546 STKLD1; serine\/threonine kinase-like domain-containing protein STKLD1" } ] }, { "name":"Bacterial family" } ] }, { "name":"Receptor serine\/threonine kinases (RSTK): TKL group", "children":[ { "name":"TGFBR1 family [OT]", "children":[ { "name":"138155049 ACVR1; (RefSeq) activin receptor type-1 isoform X1\tK04675 ACVR1; activin receptor type-1 [EC:2.7.11.30]" }, { "name":"138164620 ACVRL1; (RefSeq) activin receptor type-1-like\tK13594 ACVRL1; activin receptor-like kinase 1 [EC:2.7.11.30]" }, { "name":"138164619 ACVR1B; (RefSeq) activin receptor type-1B isoform X1\tK13567 ACVR1B; activin receptor type-1B [EC:2.7.11.30]" }, { "name":"138154709 ACVR1C; (RefSeq) activin receptor type-1C isoform X1\tK13568 ACVR1C; activin receptor type-1C [EC:2.7.11.30]" }, { "name":"138148598 BMPR1A; (RefSeq) bone morphogenetic protein receptor type-1A\tK04673 BMPR1A; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]" }, { "name":"138165971 BMPR1B; (RefSeq) bone morphogenetic protein receptor type-1B isoform X1\tK13578 BMPR1B; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]" }, { "name":"138175346 TGFBR1; (RefSeq) TGF-beta receptor type-1 isoform X1\tK04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]" } ] }, { "name":"TGFBR2 family [OT]", "children":[ { "name":"138145086 ACVR2A; (RefSeq) activin receptor type-2A isoform X1\tK04670 ACVR2A; activin receptor type-2A [EC:2.7.11.30]" }, { "name":"138157945 ACVR2B; (RefSeq) activin receptor type-2B isoform X1\tK13596 ACVR2B; activin receptor type-2B [EC:2.7.11.30]" }, { "name":"138171597 AMHR2; (RefSeq) anti-Muellerian hormone type-2 receptor\tK04672 AMHR2; anti-mullerian hormone receptor type-2 [EC:2.7.11.30]" }, { "name":"138151732 BMPR2; (RefSeq) bone morphogenetic protein receptor type-2 isoform X1\tK04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]" }, { "name":"138161713 TGFBR2; (RefSeq) TGF-beta receptor type-2\tK04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]" } ] } ] }, { "name":"Receptor tyrosine kinases (RTK)", "children":[ { "name":"EGFR family [OT]", "children":[ { "name":"138157940 EGFR; (RefSeq) epidermal growth factor receptor\tK04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]" }, { "name":"138150811 ERBB2; (RefSeq) receptor tyrosine-protein kinase erbB-2\tK05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]" }, { "name":"138154367 ERBB3; (RefSeq) receptor tyrosine-protein kinase erbB-3 isoform X1\tK05084 ERBB3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]" }, { "name":"138151668 ERBB4; (RefSeq) receptor tyrosine-protein kinase erbB-4\tK05085 ERBB4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]" } ] }, { "name":"INSR family [OT]", "children":[ { "name":"138176746 INSRR; (RefSeq) insulin receptor-related protein\tK05086 INSRR; insulin receptor-related receptor [EC:2.7.10.1]" }, { "name":"138164361 INSR; (RefSeq) insulin receptor isoform X1\tK04527 INSR; insulin receptor [EC:2.7.10.1]" }, { "name":"138169220 IGF1R; (RefSeq) insulin-like growth factor 1 receptor\tK05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]" } ] }, { "name":"PDGFR family [OT]", "children":[ { "name":"138175015 PDGFRA; (RefSeq) platelet-derived growth factor receptor alpha isoform X1\tK04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]" }, { "name":"138172874 PDGFRB; (RefSeq) platelet-derived growth factor receptor beta\tK05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]" }, { "name":"138172778 CSF1R; (RefSeq) macrophage colony-stimulating factor 1 receptor\tK05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]" }, { "name":"138175016 KIT; (RefSeq) mast\/stem cell growth factor receptor Kit isoform X1\tK05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]" }, { "name":"138154692 FLT3; (RefSeq) receptor-type tyrosine-protein kinase FLT3 isoform X1\tK05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]" } ] }, { "name":"FGFR family [OT]", "children":[ { "name":"138152113 FGFR1; (RefSeq) fibroblast growth factor receptor 1 isoform X1\tK04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]" }, { "name":"138169564 FGFR2; (RefSeq) fibroblast growth factor receptor 2 isoform X1\tK05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]" }, { "name":"138148491 FGFR3; (RefSeq) fibroblast growth factor receptor 3 isoform X1\tK05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]" }, { "name":"138153574 FGFR4; (RefSeq) fibroblast growth factor receptor 4 isoform X1\tK05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]" } ] }, { "name":"VEGFR family [OT]", "children":[ { "name":"138155206 FLT1; (RefSeq) vascular endothelial growth factor receptor 1\tK05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]" }, { "name":"138177215 vascular endothelial growth factor receptor kdr-like isoform X1\tK05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]" }, { "name":"138153564 FLT4; (RefSeq) vascular endothelial growth factor receptor 3\tK05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]" }, { "name":"138175017 KDR; (RefSeq) vascular endothelial growth factor receptor 2 isoform X1\tK05098 KDR; kinase insert domain protein receptor [EC:2.7.10.1]" } ] }, { "name":"MET family", "children":[ { "name":"138176289 MET; (RefSeq) hepatocyte growth factor receptor\tK05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]" }, { "name":"138167077 MST1R; (RefSeq) macrophage-stimulating protein receptor isoform X1\tK05100 MST1R; macrophage-stimulating 1 receptor [EC:2.7.10.1]" } ] }, { "name":"TRK family [OT]", "children":[ { "name":"138176738 NTRK1; (RefSeq) high affinity nerve growth factor receptor\tK03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]" }, { "name":"138174816 NTRK2; (RefSeq) BDNF\/NT-3 growth factors receptor isoform X1\tK04360 NTRK2; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]" }, { "name":"138169252 NTRK3; (RefSeq) NT-3 growth factor receptor isoform X1\tK05101 NTRK3; neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]" } ] }, { "name":"EPH family [OT]", "children":[ { "name":"138160703 EPHA1; (RefSeq) ephrin type-A receptor 1 isoform X1\tK05102 EPHA1; Eph receptor A1 [EC:2.7.10.1]" }, { "name":"138165595 EPHA3; (RefSeq) ephrin type-A receptor 3 isoform X1\tK05104 EPHA3; Eph receptor A3 [EC:2.7.10.1]" }, { "name":"138174323 EPHA4; (RefSeq) ephrin type-A receptor 4 isoform X1\tK05105 EPHA4; Eph receptor A4 [EC:2.7.10.1]" }, { "name":"138175045 EPHA5; (RefSeq) ephrin type-A receptor 5 isoform X1\tK05106 EPHA5; Eph receptor A5 [EC:2.7.10.1]" }, { "name":"138171274 EPHA6; (RefSeq) ephrin type-A receptor 6\tK05107 EPHA6; Eph receptor A6 [EC:2.7.10.1]" }, { "name":"138153067 EPHA7; (RefSeq) ephrin type-A receptor 7 isoform X1\tK05108 EPHA7; EphA7 [EC:2.7.10.1]" }, { "name":"138153858 EPHA8; (RefSeq) ephrin type-A receptor 8\tK05109 EPHA8; Eph receptor A8 [EC:2.7.10.1]" }, { "name":"138146228 EPHA10; (RefSeq) ephrin type-A receptor 10\tK08897 EPHA10; Eph receptor A10 [EC:2.7.10.1]" }, { "name":"138177506 EPHB1; (RefSeq) ephrin type-B receptor 1 isoform X1\tK05110 EPHB1; Eph receptor B1 [EC:2.7.10.1]" }, { "name":"138154045 EPHB2; (RefSeq) ephrin type-B receptor 2 isoform X1\tK05111 EPHB2; Eph receptor B2 [EC:2.7.10.1]" }, { "name":"138162306 EPHB3; (RefSeq) ephrin type-B receptor 3 isoform X1\tK05112 EPHB3; Eph receptor B3 [EC:2.7.10.1]" }, { "name":"138142219 EPHB4; (RefSeq) ephrin type-B receptor 4\tK05113 EPHB4; Eph receptor B4 [EC:2.7.10.1]" }, { "name":"138160693 EPHB6; (RefSeq) ephrin type-B receptor 6 isoform X1\tK05114 EPHB6; Eph receptor B6 [EC:2.7.10.1]" } ] }, { "name":"AXL family", "children":[ { "name":"138154436 AXL; (RefSeq) tyrosine-protein kinase receptor UFO isoform X1\tK05115 AXL; AXL receptor tyrosine kinase [EC:2.7.10.1]" }, { "name":"138175423 TYRO3; (RefSeq) tyrosine-protein kinase receptor TYRO3\tK05116 TYRO3; TYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]" }, { "name":"138151961 MERTK; (RefSeq) tyrosine-protein kinase Mer\tK05117 MERTK; c-mer proto-oncogene tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"ALK family", "children":[ { "name":"138149165 ALK; (RefSeq) ALK tyrosine kinase receptor\tK05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]" }, { "name":"138175304 LTK; (RefSeq) leukocyte tyrosine kinase receptor\tK05118 LTK; leukocyte tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"TIE family", "children":[ { "name":"138164761 tyrosine-protein kinase receptor Tie-1-like\tK05120 TIE1; tyrosine kinase receptor 1 [EC:2.7.10.1]" }, { "name":"138165229 tyrosine-protein kinase receptor Tie-1-like\tK05120 TIE1; tyrosine kinase receptor 1 [EC:2.7.10.1]" }, { "name":"138162908 TEK; (RefSeq) angiopoietin-1 receptor\tK05121 TEK; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"ROR family", "children":[ { "name":"138164898 inactive tyrosine-protein kinase transmembrane receptor ROR1\tK05122 ROR1; receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1]" }, { "name":"138165268 inactive tyrosine-protein kinase transmembrane receptor ROR1\tK05122 ROR1; receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1]" }, { "name":"138160655 ROR2; (RefSeq) tyrosine-protein kinase transmembrane receptor ROR2 isoform X1\tK05123 ROR2; receptor tyrosine kinase-like orphan receptor 2 [EC:2.7.10.1]" } ] }, { "name":"DDR family", "children":[ { "name":"138149952 DDR1; (RefSeq) epithelial discoidin domain-containing receptor 1 isoform X1\tK05124 DDR1; discoidin domain receptor family member 1 [EC:2.7.10.1]" }, { "name":"138166205 DDR2; (RefSeq) discoidin domain-containing receptor 2 isoform X1\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]" } ] }, { "name":"RET family", "children":[ { "name":"138146448 RET; (RefSeq) LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret\tK05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]" } ] }, { "name":"ROS family" }, { "name":"CCK family", "children":[ { "name":"138144578 PTK7; (RefSeq) inactive tyrosine-protein kinase 7\tK05127 PTK7; PTK7 protein tyrosine kinase 7 [EC:2.7.10.1]" } ] }, { "name":"RYK family", "children":[ { "name":"138177515 RYK; (RefSeq) tyrosine-protein kinase RYK isoform X1\tK05128 RYK; RYK receptor-like tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"MUSK family", "children":[ { "name":"138160107 MUSK; (RefSeq) muscle, skeletal receptor tyrosine-protein kinase\tK05129 MUSK; muscle, skeletal, receptor tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"LMR family [OT]", "children":[ { "name":"138142954 AATK; (RefSeq) serine\/threonine-protein kinase LMTK1 isoform X1\tK17480 AATK; lemur tyrosine kinase 1 [EC:2.7.10.1]" }, { "name":"138158730 LMTK2; (RefSeq) serine\/threonine-protein kinase LMTK2\tK08898 LMTK2; lemur tyrosine kinase 2 [EC:2.7.10.1]" }, { "name":"138176390 serine\/threonine-protein kinase LMTK3-like\tK08899 LMTK3; lemur tyrosine kinase 3 [EC:2.7.10.1]" } ] } ] }, { "name":"Non-receptor tyrosine kinases", "children":[ { "name":"ABL family", "children":[ { "name":"138147109 ABL1; (RefSeq) tyrosine-protein kinase ABL1 isoform X1\tK06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]" }, { "name":"138144175 ABL2; (RefSeq) tyrosine-protein kinase ABL2 isoform X1\tK08887 ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]" } ] }, { "name":"ACK family", "children":[ { "name":"138143743 TNK2; (RefSeq) activated CDC42 kinase 1 isoform X1\tK08886 TNK2; activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]" } ] }, { "name":"CSK family", "children":[ { "name":"138148482 CSK; (RefSeq) tyrosine-protein kinase CSK\tK05728 CSK; C-terminal Src kinase [EC:2.7.10.4]" }, { "name":"138160250 MATK; (RefSeq) megakaryocyte-associated tyrosine-protein kinase\tK08888 MATK; megakaryocyte-associated tyrosine kinase [EC:2.7.10.2]" } ] }, { "name":"FAK family", "children":[ { "name":"138155932 PTK2; (RefSeq) focal adhesion kinase 1 isoform X1\tK05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]" }, { "name":"138149084 PTK2B; (RefSeq) protein-tyrosine kinase 2-beta\tK05871 PTK2B; focal adhesion kinase 2 [EC:2.7.10.2]" } ] }, { "name":"FES family", "children":[ { "name":"138169304 FES; (RefSeq) tyrosine-protein kinase Fes\/Fps\tK07527 FES; tyrosine-protein kinase Fes\/Fps [EC:2.7.10.2]" }, { "name":"138161332 FER; (RefSeq) tyrosine-protein kinase Fer isoform X1\tK08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]" } ] }, { "name":"JAK family [OT]", "children":[ { "name":"138164896 tyrosine-protein kinase JAK1-like isoform X1\tK11217 JAK1; Janus kinase 1 [EC:2.7.10.2]" }, { "name":"138165128 tyrosine-protein kinase JAK1-like\tK11217 JAK1; Janus kinase 1 [EC:2.7.10.2]" }, { "name":"138163233 JAK2; (RefSeq) tyrosine-protein kinase JAK2 isoform X1\tK04447 JAK2; Janus kinase 2 [EC:2.7.10.2]" }, { "name":"138174549 JAK3; (RefSeq) tyrosine-protein kinase JAK3\tK11218 JAK3; Janus kinase 3 [EC:2.7.10.2]" }, { "name":"138157483 TYK2; (RefSeq) non-receptor tyrosine-protein kinase TYK2\tK11219 TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]" } ] }, { "name":"SRC family", "children":[ { "name":"138141883 BLK; (RefSeq) tyrosine-protein kinase Blk\tK08890 BLK; B lymphoid tyrosine kinase [EC:2.7.10.2]" }, { "name":"138154485 FGR; (RefSeq) tyrosine-protein kinase Fgr\tK08891 FGR; tyrosine-protein kinase Fgr [EC:2.7.10.2]" }, { "name":"138152918 FRK; (RefSeq) tyrosine-protein kinase FRK\tK08892 FRK; fyn-related kinase [EC:2.7.10.2]" }, { "name":"138152936 FYN; (RefSeq) tyrosine-protein kinase Fyn isoform X1\tK05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]" }, { "name":"138150458 HCK; (RefSeq) tyrosine-protein kinase HCK isoform X1\tK08893 HCK; hemopoietic cell kinase [EC:2.7.10.2]" }, { "name":"138170554 LYN; (RefSeq) tyrosine-protein kinase Lyn isoform X1\tK05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]" }, { "name":"138146308 LCK; (RefSeq) tyrosine-protein kinase Lck\tK05856 LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]" }, { "name":"138149510 PTK6; (RefSeq) protein-tyrosine kinase 6\tK08894 PTK6; protein tyrosine kinase 6 [EC:2.7.10.2]" }, { "name":"138142500 SRC; (RefSeq) proto-oncogene tyrosine-protein kinase Src isoform X1\tK05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]" }, { "name":"138149515 SRMS; (RefSeq) tyrosine-protein kinase Srms\tK08895 SRMS; tyrosine-protein kinase Srms [EC:2.7.10.2]" }, { "name":"138170419 YES1; (RefSeq) tyrosine-protein kinase Yes\tK05705 YES1; tyrosine-protein kinase Yes [EC:2.7.10.2]" } ] }, { "name":"TEC family", "children":[ { "name":"138171221 BMX; (RefSeq) cytoplasmic tyrosine-protein kinase BMX isoform X1\tK08896 BMX; cytoplasmic tyrosine-protein kinase BMX [EC:2.7.10.2]" }, { "name":"138143941 BTK; (RefSeq) tyrosine-protein kinase BTK\tK07370 BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]" }, { "name":"138172553 ITK; (RefSeq) tyrosine-protein kinase ITK\/TSK\tK07363 ITK; IL2-inducible T-cell kinase [EC:2.7.10.2]" }, { "name":"138174984 TEC; (RefSeq) tyrosine-protein kinase Tec isoform X1\tK07364 TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]" }, { "name":"138174983 TXK; (RefSeq) tyrosine-protein kinase TXK\tK08016 TXK; tyrosine-protein kinase TXK [EC:2.7.10.2]" } ] }, { "name":"SYK family", "children":[ { "name":"138160624 SYK; (RefSeq) tyrosine-protein kinase SYK isoform X1\tK05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]" }, { "name":"138175743 ZAP70; (RefSeq) tyrosine-protein kinase ZAP-70\tK07360 ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]" } ] }, { "name":"Other", "children":[ { "name":"138171935 STYK1; (RefSeq) tyrosine-protein kinase STYK1\tK17510 STYK1; tyrosine-protein kinase STYK1 [EC:2.7.10.2]" }, { "name":"138148761 PKDCC; (RefSeq) extracellular tyrosine-protein kinase PKDCC\tK17548 PKDCC; extracellular tyrosine-protein kinase PKDCC  [EC:2.7.10.2]" } ] }, { "name":"Bacterial" } ] }, { "name":"Histidine kinases", "children":[ { "name":"OmpR family" }, { "name":"NarL family" }, { "name":"Spo family [OT]" }, { "name":"CitB family [OT]" }, { "name":"LytTR family [OT]" }, { "name":"NtrC family" }, { "name":"CheA family [OT]" }, { "name":"Cell cycle family [OT]" }, { "name":"Lux family [OT]" }, { "name":"LuxR family [OT]" }, { "name":"Other" } ] } ] }