{
	"name":"pco03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"PHACADRAFT_158212 hypothetical protein\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"PHACADRAFT_252061 hypothetical protein\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"PHACADRAFT_203182 hypothetical protein\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"PHACADRAFT_203552 hypothetical protein\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"PHACADRAFT_259229 hypothetical protein\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"PHACADRAFT_266509 hypothetical protein\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"PHACADRAFT_92514 hypothetical protein\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"PHACADRAFT_96257 hypothetical protein\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"PHACADRAFT_162146 hypothetical protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"PHACADRAFT_251498 hypothetical protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"PHACADRAFT_120160 hypothetical protein\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"PHACADRAFT_153651 hypothetical protein\tK10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"PHACADRAFT_104509 hypothetical protein\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"PHACADRAFT_173871 hypothetical protein\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"PHACADRAFT_264153 hypothetical protein\tK03505 POLD4; DNA polymerase delta subunit 4"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"PHACADRAFT_99155 hypothetical protein\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"PHACADRAFT_181204 hypothetical protein\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"PHACADRAFT_262974 hypothetical protein\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"PHACADRAFT_253458 hypothetical protein\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"PHACADRAFT_102664 hypothetical protein\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"PHACADRAFT_204217 hypothetical protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"PHACADRAFT_148739 hypothetical protein\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"PHACADRAFT_246186 hypothetical protein\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"PHACADRAFT_177064 hypothetical protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"PHACADRAFT_258558 hypothetical protein\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"PHACADRAFT_253837 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"PHACADRAFT_167952 hypothetical protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"PHACADRAFT_214459 hypothetical protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"PHACADRAFT_181065 hypothetical protein\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"NER4 complex",
						"children":[
						{
							"name":"PHACADRAFT_259073 hypothetical protein\tK15082 RAD7; DNA repair protein RAD7"
						},
						{
							"name":"PHACADRAFT_114435 hypothetical protein\tK15083 RAD16; DNA repair protein RAD16"
						}
						]
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"PHACADRAFT_246551 hypothetical protein\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"PHACADRAFT_247866 hypothetical protein\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"PHACADRAFT_258319 hypothetical protein\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"PHACADRAFT_105721 hypothetical protein\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"PHACADRAFT_251606 hypothetical protein\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"PHACADRAFT_175251 hypothetical protein\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"PHACADRAFT_152837 hypothetical protein\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"PHACADRAFT_160812 hypothetical protein\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"PHACADRAFT_212353 hypothetical protein\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"PHACADRAFT_251231 hypothetical protein\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"PHACADRAFT_253837 hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"PHACADRAFT_167952 hypothetical protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"PHACADRAFT_214459 hypothetical protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"PHACADRAFT_181065 hypothetical protein\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"PHACADRAFT_71199 hypothetical protein\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"PHACADRAFT_252066 hypothetical protein\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"PHACADRAFT_256068 hypothetical protein\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"PHACADRAFT_185111 hypothetical protein\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"PHACADRAFT_258371 hypothetical protein\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"PHACADRAFT_171015 hypothetical protein\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"PHACADRAFT_210756 hypothetical protein\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"PHACADRAFT_153133 hypothetical protein\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"PHACADRAFT_84769 hypothetical protein\tK06634 CCNH; cyclin H"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"PHACADRAFT_255854 hypothetical protein\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"PHACADRAFT_173451 hypothetical protein\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"PHACADRAFT_246128 hypothetical protein\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"PHACADRAFT_28352 hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"PHACADRAFT_204003 hypothetical protein\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"PHACADRAFT_174878 hypothetical protein\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"PHACADRAFT_149022 hypothetical protein\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"PHACADRAFT_193460 hypothetical protein\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"PHACADRAFT_204217 hypothetical protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"PHACADRAFT_178404 hypothetical protein\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"PHACADRAFT_254576 hypothetical protein\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"PHACADRAFT_256936 hypothetical protein\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"PHACADRAFT_252641 hypothetical protein\tK03869 CUL3; cullin 3"
					},
					{
						"name":"PHACADRAFT_167536 hypothetical protein\tK03872 ELOC; elongin-C"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"PHACADRAFT_207767 hypothetical protein\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"PHACADRAFT_96015 hypothetical protein\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"PHACADRAFT_116507 hypothetical protein\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"PHACADRAFT_119030 hypothetical protein\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"PHACADRAFT_260955 hypothetical protein\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"PHACADRAFT_205965 hypothetical protein\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"PHACADRAFT_104509 hypothetical protein\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"PHACADRAFT_173871 hypothetical protein\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"PHACADRAFT_264153 hypothetical protein\tK03505 POLD4; DNA polymerase delta subunit 4"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"PHACADRAFT_255854 hypothetical protein\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"PHACADRAFT_173451 hypothetical protein\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"PHACADRAFT_246128 hypothetical protein\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"PHACADRAFT_28352 hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"PHACADRAFT_157248 hypothetical protein\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"PHACADRAFT_111883 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"PHACADRAFT_144345 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"PHACADRAFT_152803 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"PHACADRAFT_171504 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"PHACADRAFT_253458 hypothetical protein\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"PHACADRAFT_90326 hypothetical protein\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"PHACADRAFT_204217 hypothetical protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"PHACADRAFT_208996 hypothetical protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"PHACADRAFT_207913 hypothetical protein\tK10865 MRE11; double-strand break repair protein MRE11"
					}
					]
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"PHACADRAFT_207913 hypothetical protein\tK10865 MRE11; double-strand break repair protein MRE11"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"PHACADRAFT_248310 hypothetical protein\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"PHACADRAFT_91096 hypothetical protein\tK10871 RAD51L3; RAD51-like protein 3"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"PHACADRAFT_90029 hypothetical protein\tK10873 RAD52; DNA repair and recombination protein RAD52"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"PHACADRAFT_173301 hypothetical protein\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"PHACADRAFT_29344 hypothetical protein\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"PHACADRAFT_27241 hypothetical protein\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"PHACADRAFT_97897 hypothetical protein\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"PHACADRAFT_255854 hypothetical protein\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"PHACADRAFT_173451 hypothetical protein\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"PHACADRAFT_246128 hypothetical protein\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"PHACADRAFT_28352 hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"PHACADRAFT_251005 hypothetical protein\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"PHACADRAFT_184278 hypothetical protein\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"PHACADRAFT_250812 hypothetical protein\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"PHACADRAFT_181841 hypothetical protein\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"PHACADRAFT_102496 hypothetical protein\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"PHACADRAFT_265043 hypothetical protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"PHACADRAFT_32294 hypothetical protein\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"PHACADRAFT_266254 hypothetical protein\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"PHACADRAFT_172822 hypothetical protein\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"PHACADRAFT_149458 hypothetical protein\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"PHACADRAFT_185071 hypothetical protein\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"PHACADRAFT_102885 hypothetical protein\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"PHACADRAFT_249122 hypothetical protein\tK22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"
					},
					{
						"name":"PHACADRAFT_209630 hypothetical protein\tK25770 ZSWIM7; zinc finger SWIM domain-containing protein 7"
					},
					{
						"name":"PHACADRAFT_117246 hypothetical protein\tK22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]"
					},
					{
						"name":"PHACADRAFT_247978 hypothetical protein\tK22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]"
					},
					{
						"name":"PHACADRAFT_125288 hypothetical protein\tK14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"PHACADRAFT_116276 hypothetical protein\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"PHACADRAFT_82428 hypothetical protein\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"PHACADRAFT_207913 hypothetical protein\tK10865 MRE11; double-strand break repair protein MRE11"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"PHACADRAFT_178551 hypothetical protein\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					},
					{
						"name":"PHACADRAFT_178599 hypothetical protein\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"PHACADRAFT_176005 hypothetical protein\tK10981 POL4; DNA polymerase IV [EC:2.7.7.7]"
					},
					{
						"name":"PHACADRAFT_30808 hypothetical protein\tK10981 POL4; DNA polymerase IV [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"PHACADRAFT_54509 hypothetical protein\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					},
					{
						"name":"PHACADRAFT_252530 hypothetical protein\tK19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"PHACADRAFT_97897 hypothetical protein\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					}
					]
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components",
					"children":[
					{
						"name":"PHACADRAFT_248310 hypothetical protein\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					}
					]
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"PHACADRAFT_195070 hypothetical protein\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"PHACADRAFT_121551 hypothetical protein\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"PHACADRAFT_83158 hypothetical protein\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6",
					"children":[
					{
						"name":"PHACADRAFT_261428 hypothetical protein\tK15498 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"PHACADRAFT_211560 hypothetical protein\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"PHACADRAFT_247107 hypothetical protein\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"PHACADRAFT_208996 hypothetical protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"PHACADRAFT_140428 hypothetical protein\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"PHACADRAFT_145933 hypothetical protein\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				},
				{
					"name":"PHACADRAFT_174265 hypothetical protein\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"PHACADRAFT_204189 hypothetical protein\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"PHACADRAFT_253383 hypothetical protein\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"PHACADRAFT_209467 hypothetical protein\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"PHACADRAFT_111980 hypothetical protein\tK15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]"
				},
				{
					"name":"PHACADRAFT_197015 hypothetical protein\tK15711 SMARCA3; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]"
				},
				{
					"name":"PHACADRAFT_264835 hypothetical protein\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"PHACADRAFT_265741 hypothetical protein\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				},
				{
					"name":"PHACADRAFT_266419 hypothetical protein\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"PHACADRAFT_253458 hypothetical protein\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"PHACADRAFT_203857 hypothetical protein\tK26957 GCNA; germ cell nuclear acidic protein"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"PHACADRAFT_264515 hypothetical protein\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"PHACADRAFT_90692 hypothetical protein\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"PHACADRAFT_209489 hypothetical protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"PHACADRAFT_185902 hypothetical protein\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"PHACADRAFT_111883 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"PHACADRAFT_144345 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"PHACADRAFT_152803 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"PHACADRAFT_171504 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"PHACADRAFT_209489 hypothetical protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"PHACADRAFT_142335 hypothetical protein\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"PHACADRAFT_173471 hypothetical protein\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"PHACADRAFT_121551 hypothetical protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"PHACADRAFT_134689 hypothetical protein\tK20403 TTI1; TELO2-interacting protein 1"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"PHACADRAFT_171018 hypothetical protein\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"PHACADRAFT_181804 hypothetical protein\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"PHACADRAFT_153321 hypothetical protein\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"PHACADRAFT_175408 hypothetical protein\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"PHACADRAFT_256826 hypothetical protein\tK02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]"
				},
				{
					"name":"PHACADRAFT_181760 hypothetical protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"PHACADRAFT_250466 hypothetical protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"PHACADRAFT_259022 hypothetical protein\tK02831 RAD53; ser\/thr\/tyr protein kinase RAD53 [EC:2.7.11.-]"
				},
				{
					"name":"PHACADRAFT_203428 hypothetical protein\tK20780 MDC1; mediator of DNA damage checkpoint protein 1"
				},
				{
					"name":"PHACADRAFT_122634 hypothetical protein\tK03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]"
				},
				{
					"name":"PHACADRAFT_246626 hypothetical protein\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"PHACADRAFT_252831 hypothetical protein\tK25059 SDE2; replication stress response regulator SDE2"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"PHACADRAFT_256841 hypothetical protein\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"PHACADRAFT_166360 hypothetical protein\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"PHACADRAFT_248200 hypothetical protein\tK17815 EXO5; exonuclease V [EC:3.1.-.-]"
				},
				{
					"name":"PHACADRAFT_131239 hypothetical protein\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				},
				{
					"name":"PHACADRAFT_155682 hypothetical protein\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				},
				{
					"name":"PHACADRAFT_183223 hypothetical protein\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"PHACADRAFT_261138 hypothetical protein\tK20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"PHACADRAFT_133570 hypothetical protein\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"PHACADRAFT_28828 hypothetical protein\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"PHACADRAFT_247062 hypothetical protein\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"PHACADRAFT_263049 hypothetical protein\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"PHACADRAFT_187006 hypothetical protein\tK17816 NUDT1; 8-oxo-dGTP diphosphatase \/ 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]"
				},
				{
					"name":"PHACADRAFT_137229 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"PHACADRAFT_202842 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"PHACADRAFT_93367 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"PHACADRAFT_261748 hypothetical protein\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"PHACADRAFT_249824 hypothetical protein\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				},
				{
					"name":"PHACADRAFT_249825 hypothetical protein\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"PHACADRAFT_158212 hypothetical protein\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"PHACADRAFT_252061 hypothetical protein\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"PHACADRAFT_210092 hypothetical protein\tK01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]"
					},
					{
						"name":"PHACADRAFT_92514 hypothetical protein\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"PHACADRAFT_203883 hypothetical protein\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"PHACADRAFT_162146 hypothetical protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"PHACADRAFT_251498 hypothetical protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"PHACADRAFT_193443 hypothetical protein\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"PHACADRAFT_193443 hypothetical protein\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"PHACADRAFT_137229 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"PHACADRAFT_202842 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"PHACADRAFT_93367 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}