{
	"name":"pdk01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]",
				"children":[
				{
					"name":"PADK2_29310 putative beta-lactamase\tK18973 blaOXA-50; beta-lactamase class D OXA-50 [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class C [MT]",
				"children":[
				{
					"name":"PADK2_03765 ampC; beta-lactamase\/D-alanine carboxypeptidase\tK20320 blaPDC; beta-lactamase class C PDC [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"PADK2_16365 streptomycin 3''-phosphotransferase\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"PADK2_20015 major facilitator superfamily (MFS) transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"PADK2_02355 putative streptogramin lyase\tK18235 vgb; virginiamycin B lyase [EC:4.2.99.-]"
				},
				{
					"name":"PADK2_01640 hypothetical protein\tK18234 vat; virginiamycin A acetyltransferase [EC:2.3.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"PADK2_07590 major facilitator superfamily (MFS) transporter\tK18553 cmlR; MFS transporter, DHA1 family, chloramphenicol resistance protein"
				}
				]
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"PADK2_05050 putative acetyltransferase\tK00638 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28]"
				},
				{
					"name":"PADK2_22105 chloramphenicol acetyltransferase\tK00638 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28]"
				},
				{
					"name":"PADK2_22120 acetyltransferase\tK00638 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"PADK2_19235 major facilitator superfamily (MFS) transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases",
				"children":[
				{
					"name":"PADK2_20025 putative fosfomycin resistance protein\tK21253 fosA; glutathione S-transferase fosA [EC:2.5.1.18]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"PADK2_16675 putative two-component sensor\tK18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]"
				},
				{
					"name":"PADK2_16670 putative two-component response regulator\tK18073 parR; two-component system, OmpR family, response regulator ParR"
				},
				{
					"name":"PADK2_10365 two-component sensor, CopS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"PADK2_11850 sensor kinase CusS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"PADK2_12625 two-component sensor\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"PADK2_18535 putative two-component sensor\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"PADK2_25920 putative two-component sensor\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"PADK2_10370 two-component response regulator, CopR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"PADK2_11845 transcriptional activator protein IrlR 2\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"PADK2_12630 putative two-component response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"PADK2_18540 putative two-component response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"PADK2_25915 two-component response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"PADK2_12785 transcriptional regulator MexT\tK18297 mexT; LysR family transcriptional regulator, mexEF-oprN operon transcriptional activator"
				},
				{
					"name":"PADK2_00950 putative porin\tK18093 oprD; imipenem\/basic amino acid-specific outer membrane pore [EC:3.4.21.-]"
				},
				{
					"name":"PADK2_11150 proline porin OpdB\tK18093 oprD; imipenem\/basic amino acid-specific outer membrane pore [EC:3.4.21.-]"
				},
				{
					"name":"PADK2_20900 Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor\tK18093 oprD; imipenem\/basic amino acid-specific outer membrane pore [EC:3.4.21.-]"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"PADK2_21955 hypothetical protein\tK18346 vanW; vancomycin resistance protein VanW"
				},
				{
					"name":"PADK2_05420 peptidase M15D, VanX D-ala-D-ala dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"PADK2_21105 hypothetical protein\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"PADK2_19745 two-component sensor PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"PADK2_19750 two-component response regulator PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"PADK2_02135 multidrug resistance operon repressor MexR\tK18131 mexR; MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon"
				},
				{
					"name":"PADK2_22790 putative Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"PADK2_02150 RND multidrug efflux transporter MexB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"PADK2_22795 multidrug efflux protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"PADK2_02155 Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_04855 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_12615 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_13310 outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_27295 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]",
				"children":[
				{
					"name":"PADK2_24435 transcriptional regulator NfxB\tK18294 nfxB; TetR\/AcrR family transcriptional regulator, mexCD-oprJ operon repressor"
				},
				{
					"name":"PADK2_24430 Resistance-Nodulation-cell Division (RND) multidrug efflux membrane fusion protein MexC precursor\tK18295 mexC; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"PADK2_24425 Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexD\tK18296 mexD; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]",
				"children":[
				{
					"name":"PADK2_12785 transcriptional regulator MexT\tK18297 mexT; LysR family transcriptional regulator, mexEF-oprN operon transcriptional activator"
				},
				{
					"name":"PADK2_12780 Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexE precursor\tK18298 mexE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"PADK2_12775 RND multidrug efflux transporter MexF\tK18299 mexF; multidrug efflux pump"
				},
				{
					"name":"PADK2_12770 Multidrug efflux outer membrane protein OprN precursor\tK18300 oprN; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"PADK2_05950 TetR family transcriptional regulator\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"PADK2_05955 Resistance-Nodulation-cell Division (RND) efflux membrane fusion protein precursor\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"PADK2_05960 Resistance-Nodulation-cell Division (RND) efflux transporter\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"PADK2_02155 Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_04855 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_12615 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_13310 outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_27295 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"PADK2_15545 transcriptional regulator\tK18129 mexZ; TetR\/AcrR family transcriptional regulator, mexXY operon repressor"
				},
				{
					"name":"PADK2_15550 periplasmic multidrug efflux lipoprotein precursor\tK18094 mexX; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"PADK2_15555 multidrug efflux protein\tK18095 mexY; multidrug efflux pump"
				},
				{
					"name":"PADK2_02155 Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_04855 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_12615 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_13310 outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"PADK2_27295 putative outer membrane protein precursor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"PADK2_25360 putative transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"PADK2_06750 putative RND efflux membrane fusion protein precursor\tK19595 gesA; membrane fusion protein, gold\/copper resistance efflux system"
				},
				{
					"name":"PADK2_06755 putative RND efflux transporter\tK19594 gesB; gold\/copper resistance efflux pump"
				},
				{
					"name":"PADK2_06760 putative outer membrane protein precursor\tK19593 opmE; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"PADK2_24390 outer membrane protein precursor\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"PADK2_26360 putative outer membrane protein precursor\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"PADK2_00175 putative two-component response regulator\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"PADK2_04585 putative two-component response regulator\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"PADK2_09120 putative two-component response regulator\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"PADK2_24390 outer membrane protein precursor\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"PADK2_26360 putative outer membrane protein precursor\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"PADK2_12570 putative transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"PADK2_19235 major facilitator superfamily (MFS) transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}