{
	"name":"pgg02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"FX982_01587 Phosphate regulon sensor protein PhoR\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"FX982_01588 Phosphate regulon transcriptional regulatory protein PhoB\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)",
			"children":[
			{
				"name":"FX982_00241 Virulence sensor histidine kinase PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00242 Virulence transcriptional regulatory protein PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
			}
			]
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"FX982_01727 Osmolarity sensor protein EnvZ\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"FX982_01726 Transcriptional regulatory protein OmpR\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA",
			"children":[
			{
				"name":"FX982_00246 Sensor protein RstB\tK07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00247 Transcriptional regulatory protein OmpR\tK07661 rstA; two-component system, OmpR family, response regulator RstA"
			}
			]
		},
		{
			"name":"CpxA-CpxR (envelope stress response)",
			"children":[
			{
				"name":"FX982_02768 Transcriptional regulatory protein CpxR\tK07662 cpxR; two-component system, OmpR family, response regulator CpxR"
			}
			]
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)",
			"children":[
			{
				"name":"FX982_02404 Sensor kinase CusS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_04677 Sensor protein CzcS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_02405 Transcriptional activator protein CzcR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"FX982_04676 Transcriptional activator protein CzcR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			}
			]
		},
		{
			"name":"QseC-QseB (quorum sensing)",
			"children":[
			{
				"name":"FX982_00121 Sensor protein QseC\tK07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00122 Transcriptional regulatory protein QseB\tK07666 qseB; two-component system, OmpR family, response regulator QseB"
			}
			]
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"FX982_04361 Sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"FX982_04360 KDP operon transcriptional regulatory protein KdpE\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)",
			"children":[
			{
				"name":"FX982_00437 Swarming motility regulation sensor protein RssA\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00438 Transcriptional regulatory protein tctD\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			}
			]
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)",
			"children":[
			{
				"name":"FX982_00198 Sensor protein PfeS\tK19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00199 Transcriptional regulatory protein CpxR\tK19610 pfeR; two-component system, OmpR family, response regulator PfeR"
			}
			]
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"FX982_02766 Sensor histidine kinase CpxA\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00640 Transcriptional regulatory protein OmpR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"FX982_03002 Transcriptional regulatory protein QseB\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"FX982_04366 Transcriptional regulatory protein OmpR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"FX982_04606 Transcriptional regulatory protein CusR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"FX982_04660 Transcriptional regulatory protein OmpR\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)",
			"children":[
			{
				"name":"FX982_00200 Signal transduction histidine-protein kinase BarA\tK07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]"
			},
			{
				"name":"FX982_03755 Response regulator GacA\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			}
			]
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)",
			"children":[
			{
				"name":"FX982_02501 Virulence sensor protein BvgS\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_03363 Virulence sensor protein BvgS\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00362 Virulence factors putative positive transcription regulator BvgA\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
			},
			{
				"name":"FX982_03364 Virulence factors putative positive transcription regulator BvgA\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
			}
			]
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)",
			"children":[
			{
				"name":"FX982_01663 Sensor histidine kinase BtsS\tK08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]"
			},
			{
				"name":"FX982_01664 Sensory transduction protein LytR\tK08083 algR; two-component system, LytTR family, response regulator AlgR"
			}
			]
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"FX982_01321 Sensory histidine kinase\/phosphatase NtrB\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"FX982_01322 DNA-binding transcriptional regulator NtrC\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)",
			"children":[
			{
				"name":"FX982_00853 Transcriptional regulatory protein ZraR\tK07713 zraR; two-component system, NtrC family, response regulator HydG"
			}
			]
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)",
			"children":[
			{
				"name":"FX982_02169 Sensor protein ZraS\tK02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_02168 Regulatory protein AtoC\tK02667 pilR; two-component system, NtrC family, response regulator PilR"
			}
			]
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"FX982_00469 C4-dicarboxylate transport sensor protein DctB\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"FX982_01750 C4-dicarboxylate transport sensor protein DctB\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00470 C4-dicarboxylate transport transcriptional regulatory protein DctD\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			},
			{
				"name":"FX982_01749 C4-dicarboxylate transport transcriptional regulatory protein DctD\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			}
			]
		},
		{
			"name":"KinB-AlgB (alginate production)",
			"children":[
			{
				"name":"FX982_01424 Alginate biosynthesis sensor protein KinB\tK11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]"
			},
			{
				"name":"FX982_01423 Alginate biosynthesis transcriptional regulatory protein AlgB\tK11384 algB; two-component system, NtrC family, response regulator AlgB"
			}
			]
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"FX982_03618 Sensor protein ZraS\tK02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"FX982_03960 Chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"FX982_04776 Chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"FX982_03962 Chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"FX982_04778 Chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"FX982_02819 Chemotaxis response regulator protein-glutamate methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"FX982_03955 Chemotaxis response regulator protein-glutamate methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"FX982_04374 Chemotaxis response regulator protein-glutamate methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"FX982_04775 Chemotaxis response regulator protein-glutamate methylesterase of group 1 operon\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"FX982_02418 Chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			},
			{
				"name":"FX982_04588 Chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			},
			{
				"name":"FX982_04837 Chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)",
			"children":[
			{
				"name":"FX982_01255 Chemotaxis protein CheA\tK06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase\/response regulator)"
			},
			{
				"name":"FX982_01259 Alkaline phosphatase synthesis transcriptional regulatory protein PhoP\tK02657 pilG; twitching motility two-component system response regulator PilG"
			},
			{
				"name":"FX982_01258 Response regulator PleD\tK02658 pilH; twitching motility two-component system response regulator PilH"
			}
			]
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)",
			"children":[
			{
				"name":"FX982_02517 Gliding motility regulatory protein\tK13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE"
			},
			{
				"name":"FX982_02519 Phytochrome-like protein cph2\tK11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]"
			},
			{
				"name":"FX982_02518 Chemotaxis response regulator protein-glutamate methylesterase\tK13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]"
			}
			]
		},
		{
			"name":"Cph1-Rcp1 (light response)",
			"children":[
			{
				"name":"FX982_04297 Phytochrome-like protein cph1\tK11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)",
			"children":[
			{
				"name":"FX982_03466 Response regulator receiver protein CpdR\tK13589 cpdR; two-component system, cell cycle response regulator CpdR"
			}
			]
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)",
			"children":[
			{
				"name":"FX982_04805 Signal transduction histidine-protein kinase AtoS\tK10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]"
			},
			{
				"name":"FX982_04804 Regulatory protein AtoC\tK10943 flrC; two-component system, response regulator FlrC"
			}
			]
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)",
			"children":[
			{
				"name":"FX982_00385 C4-dicarboxylate transport sensor protein DctB\tK17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_00386 C4-dicarboxylate transport transcriptional regulatory protein DctD\tK17061 aauR; two-component system, response regulator AauR"
			}
			]
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)",
			"children":[
			{
				"name":"FX982_02368 Sensor histidine kinase RegB\tK15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]"
			},
			{
				"name":"FX982_02369 Photosynthetic apparatus regulatory protein RegA\tK15012 regA; two-component system, response regulator RegA"
			}
			]
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)",
			"children":[
			{
				"name":"FX982_00071 Signal transduction histidine-protein kinase BarA\tK20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]"
			},
			{
				"name":"FX982_03521 Autoinducer 2 sensor kinase\/phosphatase LuxQ\tK20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]"
			},
			{
				"name":"FX982_04795 hypothetical protein\tK20976 hptB; histidine phosphotransfer protein HptB"
			}
			]
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT",
			"children":[
			{
				"name":"FX982_04475 Nitrate transport protein NrtA\tK22067 nasS; two-component system, oxyanion-binding sensor"
			},
			{
				"name":"FX982_04476 putative transcriptional regulatory protein pdtaR\tK07183 nasT; two-component system, response regulator \/ RNA-binding antiterminator"
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"FX982_00913 Autoinducer 2 sensor kinase\/phosphatase LuxQ\tK20971 ladS; two-component system, sensor histidine kinase LadS"
			},
			{
				"name":"FX982_02103 Signal transduction histidine-protein kinase BarA\tK20972 retS; two-component system, sensor histidine kinase RetS"
			}
			]
		}
		]
	}
	]
}