{
	"name":"pir03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors"
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex"
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex"
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors"
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex"
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex"
				},
				{
					"name":"Ran-mediated transport factors"
				},
				{
					"name":"eIF4F and regulatory proteins"
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors"
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex"
				},
				{
					"name":"Protein phosphatase 2A"
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins"
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule"
				},
				{
					"name":"P-body specific factors"
				},
				{
					"name":"Stress granule specific factors"
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex"
				},
				{
					"name":"Lsm complex"
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors"
				},
				{
					"name":"Exosome cofactors"
				},
				{
					"name":"TRAMP complex"
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex"
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"VN12_10745 rne; Ribonuclease E\tK08300 rne; ribonuclease E [EC:3.1.26.12]"
					},
					{
						"name":"VN12_14925 rnc; Ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"VN12_17535 rny; Ribonuclease Y\tK18682 rny; ribonucrease Y [EC:3.1.-.-]"
					},
					{
						"name":"VN12_08805 rnr; Ribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
					},
					{
						"name":"VN12_10425 yhaM; 3'-5' exoribonuclease YhaM\tK03698 cbf; 3'-5' exoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"VN12_05045 rhlE_2; ATP-dependent RNA helicase RhlE\tK11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]"
					},
					{
						"name":"VN12_19950 cshA; DEAD-box ATP-dependent RNA helicase CshA\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
					},
					{
						"name":"VN12_25485 deaD; ATP-dependent RNA helicase DeaD\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
					},
					{
						"name":"VN12_00320 recQ_1; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"VN12_05055 recQ_2; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"VN12_16400 recQ_3; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"VN12_00505 eno; Enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"VN12_23210 pnp; Polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"VN12_07670 hypothetical protein\tK03628 rho; transcription termination factor Rho"
					},
					{
						"name":"VN12_10795 hypothetical protein\tK03628 rho; transcription termination factor Rho"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"VN12_21975 dnaK_3; Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"VN12_18275 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"VN12_19110 groL5_1; 60 kDa chaperonin 5\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"VN12_19120 groL5_2; 60 kDa chaperonin 5\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"VN12_10195 ppk; Polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]"
					},
					{
						"name":"VN12_10090 Polyphosphate kinase 2 (PPK2)\tK22468 ppk2; polyphosphate kinase [EC:2.7.4.34]"
					},
					{
						"name":"VN12_01955 hypothetical protein\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_04095 hypothetical protein\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_05130 hypothetical protein\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_07200 hypothetical protein\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_07900 csrA_1; Carbon storage regulator\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_10610 csrA_2; Carbon storage regulator\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_12140 hypothetical protein\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_19835 hypothetical protein\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"VN12_13775 hrpB_2; ATP-dependent RNA helicase HrpB\tK03578 hrpA; ATP-dependent RNA helicase HrpA [EC:5.6.2.6]"
					},
					{
						"name":"VN12_02540 hrpB_1; ATP-dependent RNA helicase HrpB\tK03579 hrpB; ATP-dependent RNA helicase HrpB [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome"
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}