{ "name":"pmav01001", "children":[ { "name":"Serine\/threonine kinases: AGC group", "children":[ { "name":"PKA family", "children":[ { "name":"102906259 Prkaca; (RefSeq) cAMP-dependent protein kinase catalytic subunit alpha isoform X1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"102911827 Prkacb; (RefSeq) cAMP-dependent protein kinase catalytic subunit beta isoform X1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"102928504 Prkx; (RefSeq) cAMP-dependent protein kinase catalytic subunit PRKX\tK19584 PRKX; protein kinase X [EC:2.7.11.11]" } ] }, { "name":"PKG family", "children":[ { "name":"102916699 Prkg1; (RefSeq) cGMP-dependent protein kinase 1 isoform X1\tK07376 PRKG1; cGMP-dependent protein kinase 1 [EC:2.7.11.12]" }, { "name":"102905766 Prkg2; (RefSeq) cGMP-dependent protein kinase 2 isoform X1\tK19477 PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12]" } ] }, { "name":"PKC family [OT]", "children":[ { "name":"102912068 Prkca; (RefSeq) protein kinase C alpha type isoform X1\tK02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]" }, { "name":"102903918 Prkcb; (RefSeq) protein kinase C beta type isoform X2\tK19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]" }, { "name":"102916546 Prkcg; (RefSeq) protein kinase C gamma type isoform X1\tK19663 PRKCG; classical protein kinase C gamma type [EC:2.7.11.13]" }, { "name":"102928428 Prkcd; (RefSeq) protein kinase C delta type isoform X2\tK06068 PRKCD; novel protein kinase C delta type [EC:2.7.11.13]" }, { "name":"102925292 Prkce; (RefSeq) protein kinase C epsilon type isoform X1\tK18050 PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]" }, { "name":"102921496 Prkch; (RefSeq) protein kinase C eta type isoform X1\tK18051 PRKCH; novel protein kinase C eta type [EC:2.7.11.13]" }, { "name":"102906646 Prkcq; (RefSeq) protein kinase C theta type isoform X1\tK18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]" }, { "name":"102904904 Prkcz; (RefSeq) protein kinase C zeta type isoform X1\tK18952 PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]" }, { "name":"102914384 Prkci; (RefSeq) protein kinase C iota type isoform X1\tK06069 PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]" } ] }, { "name":"PKN family", "children":[ { "name":"102903263 Pkn1; (RefSeq) serine\/threonine-protein kinase N1 isoform X3\tK06071 PKN1; serine\/threonine-protein kinase N1 [EC:2.7.11.13]" }, { "name":"102911835 Pkn2; (RefSeq) serine\/threonine-protein kinase N2 isoform X2\tK23691 PKN2; serine\/threonine-protein kinase N2 [EC:2.7.11.13]" }, { "name":"102909821 Pkn3; (RefSeq) serine\/threonine-protein kinase N3 isoform X1\tK23692 PKN3; serine\/threonine-protein kinase N3 [EC:2.7.11.13]" } ] }, { "name":"AUR family [OT]", "children":[ { "name":"102906939 Aurka; (RefSeq) aurora kinase A\tK11481 AURKA; aurora kinase A [EC:2.7.11.1]" }, { "name":"102903766 Aurkb; (RefSeq) aurora kinase B isoform X1\tK11479 AURKB; aurora kinase B [EC:2.7.11.1]" }, { "name":"102917553 Aurkc; (RefSeq) aurora kinase C\tK11480 AURKC; aurora kinase C [EC:2.7.11.1]" } ] }, { "name":"PDK1 family", "children":[ { "name":"102908871 Pdpk1; (RefSeq) 3-phosphoinositide-dependent protein kinase 1 isoform X1\tK06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]" } ] }, { "name":"AKT\/PKB family", "children":[ { "name":"102913956 Akt1; (RefSeq) RAC-alpha serine\/threonine-protein kinase\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"102916483 Akt2; (RefSeq) RAC-beta serine\/threonine-protein kinase isoform X1\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"102925608 Akt3; (RefSeq) RAC-gamma serine\/threonine-protein kinase isoform X1\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]" } ] }, { "name":"SGK family [OT]", "children":[ { "name":"102925378 Sgk1; (RefSeq) serine\/threonine-protein kinase Sgk1 isoform X1\tK13302 SGK1; serum\/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]" }, { "name":"102910180 Sgk2; (RefSeq) serine\/threonine-protein kinase Sgk2 isoform X1\tK13303 SGK2; serum\/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]" }, { "name":"102906888 Sgk3; (RefSeq) serine\/threonine-protein kinase Sgk3\tK13304 SGK3; serum\/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]" } ] }, { "name":"RSK family [OT]", "children":[ { "name":"102904189 Rps6ka3; (RefSeq) ribosomal protein S6 kinase alpha-3 isoform X2\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102909259 Rps6ka1; (RefSeq) ribosomal protein S6 kinase alpha-1 isoform X2\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102918449 Rps6ka2; (RefSeq) ribosomal protein S6 kinase alpha-2 isoform X1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102918458 Rps6ka6; (RefSeq) ribosomal protein S6 kinase alpha-6 isoform X1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102904559 Rps6ka4; (RefSeq) ribosomal protein S6 kinase alpha-4 isoform X3\tK16510 RPS6KA4; ribosomal protein S6 kinase alpha-4 [EC:2.7.11.1]" }, { "name":"102913758 Rps6ka5; (RefSeq) ribosomal protein S6 kinase alpha-5 isoform X1\tK04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]" }, { "name":"102910356 Rps6kb2; (RefSeq) ribosomal protein S6 kinase beta-2\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]" }, { "name":"102921049 Rps6kb1; (RefSeq) ribosomal protein S6 kinase beta-1 isoform X2\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]" }, { "name":"102905949 Rps6kc1; (RefSeq) ribosomal protein S6 kinase delta-1 isoform X4\tK20839 RSKL; ribosomal protein S6 kinase-like" }, { "name":"102921456 Rps6kl1; (RefSeq) ribosomal protein S6 kinase-like 1 isoform X1\tK20839 RSKL; ribosomal protein S6 kinase-like" } ] }, { "name":"NDR family", "children":[ { "name":"102916965 Stk38l; (RefSeq) serine\/threonine-protein kinase 38-like isoform X1\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]" }, { "name":"102918694 Stk38; (RefSeq) serine\/threonine-protein kinase 38\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]" }, { "name":"102903535 Lats2; (RefSeq) serine\/threonine-protein kinase LATS2 isoform X1\tK08791 LATS1_2; serine\/threonine-protein kinase LATS1\/2 [EC:2.7.11.1]" }, { "name":"102927135 Lats1; (RefSeq) serine\/threonine-protein kinase LATS1 isoform X1\tK08791 LATS1_2; serine\/threonine-protein kinase LATS1\/2 [EC:2.7.11.1]" } ] }, { "name":"MAST family [OT]", "children":[ { "name":"102906419 Mast4; (RefSeq) microtubule-associated serine\/threonine-protein kinase 4 isoform X1\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"102908058 Mast3; (RefSeq) microtubule-associated serine\/threonine-protein kinase 3 isoform X1\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"102925507 Mast2; (RefSeq) microtubule-associated serine\/threonine-protein kinase 2 isoform X17\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"102928411 Mast1; (RefSeq) microtubule-associated serine\/threonine-protein kinase 1 isoform X1\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]" }, { "name":"102908402 Mastl; (RefSeq) serine\/threonine-protein kinase greatwall isoform X1\tK16309 MASTL; serine\/threonine-protein kinase greatwall [EC:2.7.11.36]" } ] }, { "name":"YANK family", "children":[ { "name":"102906427 Stk32b; (RefSeq) serine\/threonine-protein kinase 32B isoform X1\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" }, { "name":"102912486 Stk32c; (RefSeq) serine\/threonine-protein kinase 32C\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" }, { "name":"102929012 Stk32a; (RefSeq) serine\/threonine-protein kinase 32A isoform X1\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]" } ] }, { "name":"DMPK family [OT]", "children":[ { "name":"102915010 Dmpk; (RefSeq) myotonin-protein kinase isoform X2\tK08788 DMPK; dystrophia myotonica-protein kinase [EC:2.7.11.1]" }, { "name":"102907796 Rock1; (RefSeq) rho-associated protein kinase 1\tK04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.39]" }, { "name":"102925977 Rock2; (RefSeq) rho-associated protein kinase 2\tK17388 ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.39]" }, { "name":"102902828 Cdc42bpb; (RefSeq) serine\/threonine-protein kinase MRCK beta isoform X1\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"102907801 Cdc42bpa; (RefSeq) serine\/threonine-protein kinase MRCK alpha isoform X1\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"102926523 Cdc42bpg; (RefSeq) serine\/threonine-protein kinase MRCK gamma isoform X1\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]" }, { "name":"102913022 Cit; (RefSeq) citron Rho-interacting kinase isoform X10\tK16308 CIT; citron Rho-interacting kinase [EC:2.7.11.35]" } ] }, { "name":"GRK family [OT]", "children":[ { "name":"102912578 Grk1; (RefSeq) rhodopsin kinase GRK1\tK00909 GRK1_7; rhodopsin kinase [EC:2.7.11.14]" }, { "name":"102913819 Grk2; (RefSeq) beta-adrenergic receptor kinase 1\tK00910 ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]" }, { "name":"102921348 Grk3; (RefSeq) G protein-coupled receptor kinase 3\tK00910 ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]" }, { "name":"102906902 Grk6; (RefSeq) G protein-coupled receptor kinase 6 isoform X2\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" }, { "name":"102916192 Grk5; (RefSeq) G protein-coupled receptor kinase 5 isoform X1\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" }, { "name":"102920643 Grk4; (RefSeq) G protein-coupled receptor kinase 4 isoform X1\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]" } ] }, { "name":"Other", "children":[ { "name":"102924421 Rskr; (RefSeq) ribosomal protein S6 kinase-related protein isoform X2\tK17529 SGK494; uncharacterized serine\/threonine-protein kinase SgK494 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CAMK group", "children":[ { "name":"CAMK1 family [OT]", "children":[ { "name":"102913533 Camk1g; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1G\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"102922866 Camk1; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"102924604 Camk1d; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1D isoform X1\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]" }, { "name":"102902995 Camk4; (RefSeq) calcium\/calmodulin-dependent protein kinase type IV isoform X1\tK05869 CAMK4; calcium\/calmodulin-dependent protein kinase IV [EC:2.7.11.17]" }, { "name":"102905948 Pnck; (RefSeq) calcium\/calmodulin-dependent protein kinase type 1B\tK08795 PNCK; pregnancy upregulated non-ubiquitously expressed CaM kinase [EC:2.7.11.17]" }, { "name":"102926716 Camkv; (RefSeq) caM kinase-like vesicle-associated protein isoform X2\tK08812 CAMKV; CaM kinase-like vesicle-associated [EC:2.7.11.-]" } ] }, { "name":"CAMK2 family", "children":[ { "name":"102913726 Camk2a; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit alpha isoform X1\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"102914572 Camk2d; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit delta isoform X2\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"102927777 Camk2b; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit beta isoform X1\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" }, { "name":"102928335 Camk2g; (RefSeq) calcium\/calmodulin-dependent protein kinase type II subunit gamma isoform X33\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]" } ] }, { "name":"CAMKL family", "children":[ { "name":"102912185 Brsk1; (RefSeq) serine\/threonine-protein kinase BRSK1 isoform X1\tK08796 BRSK; BR serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"102920304 Brsk2; (RefSeq) serine\/threonine-protein kinase BRSK2 isoform X1\tK08796 BRSK; BR serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"102928359 Chek1; (RefSeq) serine\/threonine-protein kinase Chk1 isoform X1\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]" }, { "name":"102913416 Hunk; (RefSeq) hormonally up-regulated neu tumor-associated kinase\tK08797 HUNK; hormonally upregulated Neu-associated kinase [EC:2.7.11.1]" }, { "name":"102904884 Mark3; (RefSeq) MAP\/microtubule affinity-regulating kinase 3 isoform X12\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"102909215 Mark1; (RefSeq) serine\/threonine-protein kinase MARK1 isoform X8\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"102913931 Mark2; (RefSeq) serine\/threonine-protein kinase MARK2 isoform X6\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"102921909 Mark4; (RefSeq) MAP\/microtubule affinity-regulating kinase 4 isoform X1\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]" }, { "name":"102925813 Melk; (RefSeq) maternal embryonic leucine zipper kinase\tK08799 MELK; maternal embryonic leucine zipper kinase [EC:2.7.11.1]" }, { "name":"102911431 Nim1k; (RefSeq) serine\/threonine-protein kinase NIM1\tK16310 NIM1; serine\/threonine-protein kinase NIM1 [EC:2.7.11.1]" }, { "name":"102916012 Nuak1; (RefSeq) NUAK family SNF1-like kinase 1 isoform X1\tK08800 NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]" }, { "name":"102921568 Nuak2; (RefSeq) NUAK family SNF1-like kinase 2\tK08800 NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]" }, { "name":"102919730 Pask; (RefSeq) PAS domain-containing serine\/threonine-protein kinase\tK08801 PASK; PAS domain containing serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"102912964 Prkaa1; (RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]" }, { "name":"102917053 Prkaa2; (RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]" }, { "name":"102904171 Sik1; (RefSeq) serine\/threonine-protein kinase SIK1\tK19008 SIK1; serine\/threonine-protein kinase SIK1 [EC:2.7.11.1]" }, { "name":"102904509 Sik2; (RefSeq) serine\/threonine-protein kinase SIK2 isoform X1\tK16311 SIK2; serine\/threonine-protein kinase SIK2 [EC:2.7.11.1]" }, { "name":"102925158 Sik3; (RefSeq) serine\/threonine-protein kinase SIK3 isoform X1\tK19009 SIK3; serine\/threonine-protein kinase SIK3 [EC:2.7.11.1]" }, { "name":"102908043 Snrk; (RefSeq) SNF-related serine\/threonine-protein kinase isoform X1\tK08802 SNRK; SNF related kinase [EC:2.7.11.1]" }, { "name":"102907637 Stk11; (RefSeq) serine\/threonine-protein kinase STK11 isoform X1\tK07298 STK11; serine\/threonine-protein kinase 11 [EC:2.7.11.1]" } ] }, { "name":"DAPK family", "children":[ { "name":"102910347 Dapk2; (RefSeq) death-associated protein kinase 2 isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"102919597 Dapk1; (RefSeq) death-associated protein kinase 1 isoform X2\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"121825188 Dapk3; (RefSeq) death-associated protein kinase 3 isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]" }, { "name":"102917214 Stk17b; (RefSeq) serine\/threonine-protein kinase 17B\tK08804 STK17; serine\/threonine kinase 17 [EC:2.7.11.1]" } ] }, { "name":"DCAMKL family", "children":[ { "name":"102904936 Dclk1; (RefSeq) serine\/threonine-protein kinase DCLK1 isoform X1\tK08805 DCLK1_2; doublecortin-like kinase 1\/2 [EC:2.7.11.1]" }, { "name":"102919775 Dclk2; (RefSeq) serine\/threonine-protein kinase DCLK2 isoform X1\tK08805 DCLK1_2; doublecortin-like kinase 1\/2 [EC:2.7.11.1]" }, { "name":"102924724 Dclk3; (RefSeq) serine\/threonine-protein kinase DCLK3\tK17530 DCLK3; doublecortin-like kinase 3 [EC:2.7.11.1]" } ] }, { "name":"MAPKAPK family [OT]", "children":[ { "name":"102919658 Mapkapk2; (RefSeq) MAP kinase-activated protein kinase 2\tK04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]" }, { "name":"102909481 Mapkapk3; (RefSeq) MAP kinase-activated protein kinase 3\tK04444 MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]" }, { "name":"102922416 Mapkapk5; (RefSeq) MAP kinase-activated protein kinase 5 isoform X1\tK04442 MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]" }, { "name":"102904154 Mknk1; (RefSeq) MAP kinase-interacting serine\/threonine-protein kinase 1 isoform X1\tK04372 MKNK; MAP kinase interacting serine\/threonine kinase [EC:2.7.11.1]" }, { "name":"102924007 Mknk2; (RefSeq) MAP kinase-interacting serine\/threonine-protein kinase 2 isoform X1\tK04372 MKNK; MAP kinase interacting serine\/threonine kinase [EC:2.7.11.1]" } ] }, { "name":"MLCK family", "children":[ { "name":"102907697 Mylk3; (RefSeq) myosin light chain kinase 3 isoform X1\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"102914808 Mylk; (RefSeq) myosin light chain kinase, smooth muscle isoform X2\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"102918526 Mylk4; (RefSeq) myosin light chain kinase family member 4 isoform X1\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" }, { "name":"102919413 Mylk2; (RefSeq) myosin light chain kinase 2, skeletal\/cardiac muscle\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]" } ] }, { "name":"PHK family", "children":[ { "name":"102906699 Phkg2; (RefSeq) phosphorylase b kinase gamma catalytic chain, liver\/testis isoform isoform X1\tK00871 PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]" }, { "name":"102912400 Phkg1; (RefSeq) phosphorylase b kinase gamma catalytic chain, skeletal muscle\/heart isoform isoform X1\tK00871 PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]" } ] }, { "name":"PIM family [OT]", "children":[ { "name":"102914859 Pim1; (RefSeq) serine\/threonine-protein kinase pim-1 isoform X1\tK04702 PIM1; proto-oncogene serine\/threonine-protein kinase Pim-1 [EC:2.7.11.1]" }, { "name":"102912869 Pim2; (RefSeq) serine\/threonine-protein kinase pim-2\tK08806 PIM2; proto-oncogene serine\/threonine-protein kinase Pim-2 [EC:2.7.11.1]" }, { "name":"102913165 Pim3; (RefSeq) serine\/threonine-protein kinase pim-3\tK08807 PIM3; proto-oncogene serine\/threonine-protein kinase Pim-3 [EC:2.7.11.1]" } ] }, { "name":"PKD family", "children":[ { "name":"102917722 Prkd1; (RefSeq) serine\/threonine-protein kinase D1 isoform X1\tK06070 PKD; protein kinase D [EC:2.7.11.13]" }, { "name":"102924474 Prkd3; (RefSeq) serine\/threonine-protein kinase D3\tK06070 PKD; protein kinase D [EC:2.7.11.13]" }, { "name":"102928261 Prkd2; (RefSeq) serine\/threonine-protein kinase D2\tK06070 PKD; protein kinase D [EC:2.7.11.13]" } ] }, { "name":"PSK family", "children":[ { "name":"102923419 Pskh1; (RefSeq) serine\/threonine-protein kinase H1\tK08808 PSKH; protein serine kinase H [EC:2.7.11.1]" } ] }, { "name":"RAD53 family", "children":[ { "name":"102917158 Chek2; (RefSeq) serine\/threonine-protein kinase Chk2 isoform X2\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]" } ] }, { "name":"Trio family [OT]", "children":[ { "name":"102915683 Trio; (RefSeq) triple functional domain protein isoform X4\tK08810 TRIO; triple functional domain protein [EC:2.7.11.1]" }, { "name":"102926086 Obscn; (RefSeq) obscurin isoform X1\tK17531 OBSCN; obscurin-RhoGEF [EC:2.7.11.1]" } ] }, { "name":"TSSK family", "children":[ { "name":"102910214 Tssk6; (RefSeq) testis-specific serine\/threonine-protein kinase 6\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"102911123 Tssk4; (RefSeq) testis-specific serine\/threonine-protein kinase 4 isoform X1\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"102920594 Tssk3; (RefSeq) testis-specific serine\/threonine-protein kinase 3\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"102926418 Tssk1b; (RefSeq) testis-specific serine\/threonine-protein kinase 1\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" }, { "name":"102926732 Tssk2; (RefSeq) testis-specific serine\/threonine-protein kinase 2\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]" } ] }, { "name":"CDPK family" }, { "name":"CASK family", "children":[ { "name":"102907921 Cask; (RefSeq) peripheral plasma membrane protein CASK isoform X14\tK06103 CASK; calcium\/calmodulin-dependent serine protein kinase [EC:2.7.11.1]" } ] }, { "name":"Trbl family", "children":[ { "name":"102904168 Trib1; (RefSeq) tribbles homolog 1\tK08814 TRIB1_2; tribbles homolog 1\/2" }, { "name":"102922859 Trib2; (RefSeq) tribbles homolog 2\tK08814 TRIB1_2; tribbles homolog 1\/2" }, { "name":"102925810 Trib3; (RefSeq) tribbles homolog 3\tK19518 TRIB3; tribbles homolog 3" } ] }, { "name":"Other", "children":[ { "name":"102919273 Stk33; (RefSeq) serine\/threonine-protein kinase 33\tK08813 STK33; serine\/threonine kinase 33 [EC:2.7.11.1]" }, { "name":"102914232 Stk40; (RefSeq) serine\/threonine-protein kinase 40\tK16312 STK40; serine\/threonine-protein kinase 40 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CK1 group", "children":[ { "name":"CK1 family [OT]", "children":[ { "name":"102917663 Csnk1a1; (RefSeq) casein kinase I isoform X1\tK08957 CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]" }, { "name":"102902998 Csnk1g2; (RefSeq) casein kinase I isoform X1\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"102908173 Csnk1g3; (RefSeq) casein kinase I isoform X1\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"102926718 Csnk1g1; (RefSeq) casein kinase I isoform X2\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]" }, { "name":"102907461 Csnk1d; (RefSeq) casein kinase I isoform X1\tK08959 CSNK1D; casein kinase 1, delta [EC:2.7.11.1]" }, { "name":"102921851 Csnk1e; (RefSeq) casein kinase I isoform X2\tK08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]" } ] }, { "name":"TTBK family", "children":[ { "name":"102903711 Ttbk2; (RefSeq) tau-tubulin kinase 2 isoform X1\tK08815 TTBK; tau tubulin kinase [EC:2.7.11.26]" }, { "name":"102914993 Ttbk1; (RefSeq) tau-tubulin kinase 1 isoform X1\tK08815 TTBK; tau tubulin kinase [EC:2.7.11.26]" } ] }, { "name":"VRK family", "children":[ { "name":"102905814 Vrk3; (RefSeq) serine\/threonine-protein kinase VRK3 isoform X1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" }, { "name":"102911341 Vrk1; (RefSeq) serine\/threonine-protein kinase VRK1 isoform X6\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" }, { "name":"102914509 Vrk2; (RefSeq) serine\/threonine-protein kinase VRK2\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: CMGC group", "children":[ { "name":"CDK family", "children":[ { "name":"102903422 Cdk20; (RefSeq) cyclin-dependent kinase 20 isoform X1\tK08817 CDK20; cyclin-dependent kinase 20 [EC:2.7.11.22]" }, { "name":"102909540 Cdk11b; (RefSeq) cyclin-dependent kinase 11B isoform X1\tK08818 CDC2L; cell division cycle 2-like [EC:2.7.11.22]" }, { "name":"102911775 Cdk1; (RefSeq) cyclin-dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102906333 Cdk2; (RefSeq) cyclin-dependent kinase 2 isoform X2\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]" }, { "name":"102920480 Cdk3; (RefSeq) cyclin-dependent kinase 3\tK02088 CDK3; cyclin-dependent kinase 3 [EC:2.7.11.22]" }, { "name":"102904190 Cdk4; (RefSeq) cyclin-dependent kinase 4\tK02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]" }, { "name":"102923482 Cdk5; (RefSeq) cyclin-dependent kinase 5 isoform X1\tK02090 CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]" }, { "name":"102915619 Cdk6; (RefSeq) cyclin-dependent kinase 6\tK02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]" }, { "name":"102903824 Cdk7; (RefSeq) cyclin-dependent kinase 7 isoform X1\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102927533 Cdk19; (RefSeq) cyclin-dependent kinase 19 isoform X1\tK02208 CDK8_11; cyclin-dependent kinase 8\/11 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102928224 Cdk8; (RefSeq) cyclin-dependent kinase 8 isoform X1\tK02208 CDK8_11; cyclin-dependent kinase 8\/11 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102910041 Cdk9; (RefSeq) cyclin-dependent kinase 9\tK02211 CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102905711 Cdk10; (RefSeq) cyclin-dependent kinase 10 isoform X1\tK02449 CDK10; cyclin-dependent kinase 10 [EC:2.7.11.22]" }, { "name":"102911976 Cdk12; (RefSeq) cyclin-dependent kinase 12 isoform X3\tK08819 CDK12_13; cyclin-dependent kinase 12\/13 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102927019 Cdk13; (RefSeq) cyclin-dependent kinase 13 isoform X3\tK08819 CDK12_13; cyclin-dependent kinase 12\/13 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102907362 Cdk14; (RefSeq) cyclin-dependent kinase 14 isoform X5\tK08821 CDK14; cyclin-dependent kinase 14 [EC:2.7.11.22]" }, { "name":"102919557 Cdk15; (RefSeq) cyclin-dependent kinase 15 isoform X1\tK15594 CDK15; cyclin-dependent kinase 15 [EC:2.7.11.22]" }, { "name":"102913326 Cdk17; (RefSeq) cyclin-dependent kinase 17\tK15595 CDK17; cyclin-dependent kinase 17 [EC:2.7.11.22]" }, { "name":"102916866 Cdk18; (RefSeq) cyclin-dependent kinase 18 isoform X2\tK15596 CDK18; cyclin-dependent kinase 18 [EC:2.7.11.22]" } ] }, { "name":"MAPK family [OT]", "children":[ { "name":"102904106 Mapk3; (RefSeq) mitogen-activated protein kinase 3\tK04371 ERK; mitogen-activated protein kinase 1\/3 [EC:2.7.11.24]" }, { "name":"102918009 Mapk1; (RefSeq) mitogen-activated protein kinase 1\tK04371 ERK; mitogen-activated protein kinase 1\/3 [EC:2.7.11.24]" }, { "name":"102914504 Mapk6; (RefSeq) mitogen-activated protein kinase 6\tK06855 MAPK4_6; mitogen-activated protein kinase 4\/6 [EC:2.7.11.24]" }, { "name":"102918415 Mapk4; (RefSeq) mitogen-activated protein kinase 4\tK06855 MAPK4_6; mitogen-activated protein kinase 4\/6 [EC:2.7.11.24]" }, { "name":"102907496 Mapk7; (RefSeq) mitogen-activated protein kinase 7 isoform X1\tK04464 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.11.24]" }, { "name":"102905405 Mapk15; (RefSeq) mitogen-activated protein kinase 15 isoform X8\tK19603 MAPK15; mitogen-activated protein kinase 15 [EC:2.7.11.24]" }, { "name":"102908318 Mapk8; (RefSeq) mitogen-activated protein kinase 8 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"102909110 Mapk9; (RefSeq) mitogen-activated protein kinase 9 isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"102917009 Mapk10; (RefSeq) mitogen-activated protein kinase 10 isoform X2\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]" }, { "name":"102915965 Mapk12; (RefSeq) mitogen-activated protein kinase 12\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"102916291 Mapk11; (RefSeq) mitogen-activated protein kinase 11 isoform X7\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"102920948 Mapk13; (RefSeq) mitogen-activated protein kinase 13\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"102921259 Mapk14; (RefSeq) mitogen-activated protein kinase 14 isoform X2\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]" }, { "name":"102924740 Nlk; (RefSeq) serine\/threonine-protein kinase NLK isoform X1\tK04468 NLK; nemo like kinase [EC:2.7.11.24]" } ] }, { "name":"GSK family [OT]", "children":[ { "name":"102921880 Gsk3a; (RefSeq) glycogen synthase kinase-3 alpha\tK08822 GSK3A; glycogen synthase kinase 3 alpha [EC:2.7.11.26]" }, { "name":"102913056 Gsk3b; (RefSeq) glycogen synthase kinase-3 beta isoform X5\tK03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]" } ] }, { "name":"CLK family", "children":[ { "name":"102912070 Clk4; (RefSeq) dual specificity protein kinase CLK4 isoform X3\tK23561 CLK1_4; dual specificity protein kinase CLK1\/4 [EC:2.7.12.1]" }, { "name":"102925764 Clk1; (RefSeq) dual specificity protein kinase CLK1 isoform X1\tK23561 CLK1_4; dual specificity protein kinase CLK1\/4 [EC:2.7.12.1]" }, { "name":"102906972 Clk3; (RefSeq) dual specificity protein kinase CLK3 isoform X1\tK08823 CLK2_3; dual specificity protein kinase CLK2\/3 [EC:2.7.12.1]" }, { "name":"102921418 Clk2; (RefSeq) dual specificity protein kinase CLK2 isoform X5\tK08823 CLK2_3; dual specificity protein kinase CLK2\/3 [EC:2.7.12.1]" } ] }, { "name":"CDKL family", "children":[ { "name":"102904379 Cdkl4; (RefSeq) cyclin-dependent kinase-like 4 isoform X1\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"102906324 Cdkl1; (RefSeq) cyclin-dependent kinase-like 1 isoform X1\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"102907072 Cdkl3; (RefSeq) cyclin-dependent kinase-like 3 isoform X3\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"102910936 Cdkl2; (RefSeq) cyclin-dependent kinase-like 2\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" }, { "name":"102926976 Cdkl5; (RefSeq) cyclin-dependent kinase-like 5 isoform X2\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]" } ] }, { "name":"DYRK family [OT]", "children":[ { "name":"102914310 Dyrk1b; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2\tK08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]" }, { "name":"102916208 Dyrk1a; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1\tK08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]" }, { "name":"102917821 Dyrk2; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"102918751 Dyrk3; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 3\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"102929157 Dyrk4; (RefSeq) dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X4\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]" }, { "name":"102906212 Hipk1; (RefSeq) homeodomain-interacting protein kinase 1 isoform X1\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"102908536 Hipk3; (RefSeq) homeodomain-interacting protein kinase 3 isoform X4\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"102918242 homeodomain-interacting protein kinase 4\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"102927163 Hipk2; (RefSeq) homeodomain-interacting protein kinase 2 isoform X1\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"143273941 Hipk4; (RefSeq) homeodomain-interacting protein kinase 4\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]" }, { "name":"102924648 Prp4k; (RefSeq) serine\/threonine-protein kinase PRP4 homolog\tK08827 PRPF4B; serine\/threonine-protein kinase PRP4 [EC:2.7.11.1]" } ] }, { "name":"RCK family [OT]", "children":[ { "name":"102903769 Cilk1; (RefSeq) serine\/threonine-protein kinase ICK\tK08828 ICK; intestinal cell (MAK-like) kinase [EC:2.7.11.22]" }, { "name":"102923974 Mak; (RefSeq) serine\/threonine-protein kinase MAK isoform X1\tK08829 MAK; male germ cell-associated kinase [EC:2.7.11.22]" }, { "name":"102921692 Mok; (RefSeq) MAPK\/MAK\/MRK overlapping kinase isoform X4\tK08830 RAGE; renal tumor antigen [EC:2.7.11.22]" } ] }, { "name":"SRPK family [OT]", "children":[ { "name":"102922075 Srpk1; (RefSeq) SRSF protein kinase 1 isoform X1\tK15409 SRPK1; serine\/threonine-protein kinase SRPK1 [EC:2.7.11.1]" }, { "name":"102927057 Srpk2; (RefSeq) SRSF protein kinase 2 isoform X5\tK08831 SRPK2; serine\/threonine-protein kinase SRPK2 [EC:2.7.11.1]" }, { "name":"102903360 Srpk3; (RefSeq) SRSF protein kinase 3 isoform X1\tK08832 SRPK3; serine\/threonine-protein kinase SRPK3 [EC:2.7.11.1]" } ] } ] }, { "name":"Serine\/threonine kinases: STE group", "children":[ { "name":"STE7 family", "children":[ { "name":"102908507 Map2k1; (RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1\tK04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]" }, { "name":"102918665 Map2k2; (RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X2\tK04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]" }, { "name":"102910626 Map2k3; (RefSeq) dual specificity mitogen-activated protein kinase kinase 3\tK04432 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]" }, { "name":"102912305 Map2k5; (RefSeq) dual specificity mitogen-activated protein kinase kinase 5 isoform X3\tK04463 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.12.2]" }, { "name":"102908917 Map2k6; (RefSeq) dual specificity mitogen-activated protein kinase kinase 6 isoform X1\tK04433 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]" }, { "name":"102914781 Map2k7; (RefSeq) dual specificity mitogen-activated protein kinase kinase 7 isoform X2\tK04431 MAP2K7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]" } ] }, { "name":"STE20 family", "children":[ { "name":"102928613 Map4k1; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 1 isoform X1\tK04408 MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]" }, { "name":"102927732 Map4k2; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 2\tK04414 MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [EC:2.7.11.1]" }, { "name":"102904690 Map4k3; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 3 isoform X3\tK04406 MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]" }, { "name":"102908240 Map4k4; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 4 isoform X1\tK04407 MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [EC:2.7.11.1]" }, { "name":"102906630 Map4k5; (RefSeq) mitogen-activated protein kinase kinase kinase kinase 5 isoform X1\tK08833 MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5 [EC:2.7.11.1]" }, { "name":"102909984 Mink1; (RefSeq) misshapen-like kinase 1 isoform X1\tK04413 MINK; misshapen\/NIK-related kinase [EC:2.7.11.1]" }, { "name":"102926870 Tnik; (RefSeq) TRAF2 and NCK-interacting protein kinase isoform X2\tK08840 TNIK; TRAF2 and NCK interacting kinase [EC:2.7.11.1]" }, { "name":"102920484 Nrk; (RefSeq) nik-related protein kinase isoform X1\tK16313 NRK; Nik-related protein kinase [EC:2.7.11.1]" }, { "name":"102921776 Myo3a; (RefSeq) myosin-IIIa\tK08834 MYO3; myosin III [EC:2.7.11.1]" }, { "name":"102925953 Myo3b; (RefSeq) myosin-IIIb\tK08834 MYO3; myosin III [EC:2.7.11.1]" }, { "name":"102918836 Stk39; (RefSeq) STE20\/SPS1-related proline-alanine-rich protein kinase isoform X1\tK08835 OXSR1; serine\/threonine-protein kinase OSR1\/STK39 [EC:2.7.11.1]" }, { "name":"102921267 Oxsr1; (RefSeq) serine\/threonine-protein kinase OSR1 isoform X1\tK08835 OXSR1; serine\/threonine-protein kinase OSR1\/STK39 [EC:2.7.11.1]" }, { "name":"102907126 Pak1; (RefSeq) serine\/threonine-protein kinase PAK 1\tK04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]" }, { "name":"102927189 Pak2; (RefSeq) serine\/threonine-protein kinase PAK 2\tK04410 PAK2; p21-activated kinase 2 [EC:2.7.11.1]" }, { "name":"102906039 Pak3; (RefSeq) serine\/threonine-protein kinase PAK 3 isoform X1\tK05733 PAK3; p21-activated kinase 3 [EC:2.7.11.1]" }, { "name":"102926429 Pak4; (RefSeq) serine\/threonine-protein kinase PAK 4\tK05734 PAK4; p21-activated kinase 4 [EC:2.7.11.1]" }, { "name":"102920636 Pak5; (RefSeq) serine\/threonine-protein kinase PAK 5\tK05736 PAK5; p21-activated kinase 5 [EC:2.7.11.1]" }, { "name":"102921140 Pak6; (RefSeq) serine\/threonine-protein kinase PAK 6\tK05735 PAK6; p21-activated kinase 6 [EC:2.7.11.1]" }, { "name":"102908670 Slk; (RefSeq) STE20-like serine\/threonine-protein kinase isoform X2\tK08836 SLK; STE20-like kinase [EC:2.7.11.1]" }, { "name":"102913075 Stk10; (RefSeq) serine\/threonine-protein kinase 10 isoform X2\tK08837 STK10; serine\/threonine kinase 10 [EC:2.7.11.1]" }, { "name":"102925631 Strada; (RefSeq) STE20-related kinase adapter protein alpha isoform X4\tK08271 STRADA; STE20-related kinase adapter protein alpha" }, { "name":"102921713 Stradb; (RefSeq) STE20-related kinase adapter protein beta\tK17532 STRADB; STE20-related kinase adapter protein beta" }, { "name":"102906397 Stk3; (RefSeq) serine\/threonine-protein kinase 3 isoform X4\tK04412 STK3; serine\/threonine kinase 3" }, { "name":"102921684 Stk4; (RefSeq) serine\/threonine-protein kinase 4\tK04411 STK4; serine\/threonine kinase 4" }, { "name":"102903199 Stk24; (RefSeq) serine\/threonine-protein kinase 24 isoform X2\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"102918912 Stk25; (RefSeq) serine\/threonine-protein kinase 25\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"102928289 Stk26; (RefSeq) serine\/threonine-protein kinase 26 isoform X2\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"102910608 Taok3; (RefSeq) serine\/threonine-protein kinase TAO3\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" }, { "name":"102920507 Taok2; (RefSeq) serine\/threonine-protein kinase TAO2 isoform X1\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" }, { "name":"102922239 Taok1; (RefSeq) serine\/threonine-protein kinase TAO1 isoform X1\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]" } ] }, { "name":"STE11 family", "children":[ { "name":"102911400 Map3k1; (RefSeq) mitogen-activated protein kinase kinase kinase 1\tK04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]" }, { "name":"102905155 Map3k2; (RefSeq) mitogen-activated protein kinase kinase kinase 2\tK04420 MAP3K2; mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]" }, { "name":"102926657 Map3k3; (RefSeq) mitogen-activated protein kinase kinase kinase 3 isoform X3\tK04421 MAP3K3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]" }, { "name":"102907635 Map3k4; (RefSeq) mitogen-activated protein kinase kinase kinase 4 isoform X2\tK04428 MAP3K4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]" }, { "name":"102910028 Map3k5; (RefSeq) mitogen-activated protein kinase kinase kinase 5\tK04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]" }, { "name":"102903687 Map3k6; (RefSeq) mitogen-activated protein kinase kinase kinase 6 isoform X1\tK04425 MAP3K6; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]" }, { "name":"102914903 Map3k15; (RefSeq) mitogen-activated protein kinase kinase kinase 15\tK13986 MAP3K15; mitogen-activated protein kinase kinase kinase 15 [EC:2.7.11.25]" }, { "name":"102925845 Map3k19; (RefSeq) mitogen-activated protein kinase kinase kinase 19\tK17533 MAP3K19; mitogen-activated protein kinase kinase kinase 19 [EC:2.7.11.25]" } ] }, { "name":"Other", "children":[ { "name":"102913968 Map3k8; (RefSeq) mitogen-activated protein kinase kinase kinase 8 isoform X2\tK04415 MAP3K8; mitogen-activated protein kinase kinase kinase 8 [EC:2.7.11.25]" }, { "name":"102913338 Map3k14; (RefSeq) mitogen-activated protein kinase kinase kinase 14\tK04466 MAP3K14; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]" } ] } ] }, { "name":"Serine\/threonine kinases: TKL group", "children":[ { "name":"IRAK family", "children":[ { "name":"102925638 Irak1; (RefSeq) interleukin-1 receptor-associated kinase 1 isoform X1\tK04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]" }, { "name":"102927384 Irak2; (RefSeq) interleukin-1 receptor-associated kinase-like 2 isoform X1\tK04731 IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]" }, { "name":"102915944 Irak3; (RefSeq) interleukin-1 receptor-associated kinase 3\tK04732 IRAK3; interleukin-1 receptor-associated kinase 3 [EC:2.7.11.1]" }, { "name":"102922961 Irak4; (RefSeq) interleukin-1 receptor-associated kinase 4\tK04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]" } ] }, { "name":"LISK family [OT]", "children":[ { "name":"102926353 Limk1; (RefSeq) LIM domain kinase 1 isoform X1\tK05743 LIMK1; LIM domain kinase 1 [EC:2.7.11.1]" }, { "name":"102905745 Limk2; (RefSeq) LIM domain kinase 2 isoform X1\tK05744 LIMK2; LIM domain kinase 2 [EC:2.7.11.1]" }, { "name":"102905610 Tesk1; (RefSeq) dual specificity testis-specific protein kinase 1\tK08841 TESK1; testis-specific kinase 1 [EC:2.7.12.1]" }, { "name":"102920252 Tesk2; (RefSeq) dual specificity testis-specific protein kinase 2 isoform X1\tK08842 TESK2; testis-specific kinase 2 [EC:2.7.12.1]" } ] }, { "name":"LRRK family", "children":[ { "name":"102919066 Lrrk1; (RefSeq) leucine-rich repeat serine\/threonine-protein kinase 1 isoform X1\tK08843 LRRK1; leucine-rich repeat kinase 1 [EC:2.7.11.1]" }, { "name":"102922834 Lrrk2; (RefSeq) leucine-rich repeat serine\/threonine-protein kinase 2 isoform X1\tK08844 LRRK2; leucine-rich repeat kinase 2 [EC:2.7.11.1]" } ] }, { "name":"MLK family", "children":[ { "name":"102904529 Map3k7; (RefSeq) mitogen-activated protein kinase kinase kinase 7 isoform X2\tK04427 MAP3K7; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]" }, { "name":"102904188 Map3k9; (RefSeq) mitogen-activated protein kinase kinase kinase 9 isoform X2\tK04417 MAP3K9; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]" }, { "name":"102915848 Map3k10; (RefSeq) mitogen-activated protein kinase kinase kinase 10 isoform X2\tK04418 MAP3K10; mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]" }, { "name":"102911706 Map3k11; (RefSeq) mitogen-activated protein kinase kinase kinase 11 isoform X1\tK04419 MAP3K11; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]" }, { "name":"102905912 Map3k21; (RefSeq) mitogen-activated protein kinase kinase kinase 21\tK17534 MLK4; mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]" }, { "name":"102906461 Map3k20; (RefSeq) mitogen-activated protein kinase kinase kinase 20 isoform X2\tK04424 ZAK; sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25]" }, { "name":"102911101 Map3k12; (RefSeq) mitogen-activated protein kinase kinase kinase 12 isoform X4\tK04423 MAP3K12; mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]" }, { "name":"102907969 Map3k13; (RefSeq) mitogen-activated protein kinase kinase kinase 13\tK04422 MAP3K13; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]" }, { "name":"102906070 Tnni3k; (RefSeq) serine\/threonine-protein kinase TNNI3K isoform X1\tK17535 TNNI3K; serine\/threonine-protein kinase TNNI3K [EC:2.7.11.1]" }, { "name":"102911972 Ilk; (RefSeq) scaffold protein ILK\tK06272 ILK; integrin-linked kinase [EC:2.7.11.1]" } ] }, { "name":"RAF family [OT]", "children":[ { "name":"102908602 Araf; (RefSeq) serine\/threonine-protein kinase A-Raf isoform X2\tK08845 ARAF; A-Raf proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"102907686 Braf; (RefSeq) serine\/threonine-protein kinase B-raf isoform X10\tK04365 BRAF; B-Raf proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"102913391 Raf1; (RefSeq) RAF proto-oncogene serine\/threonine-protein kinase\tK04366 RAF1; RAF proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"102911075 Ksr1; (RefSeq) kinase suppressor of Ras 1 isoform X1\tK14958 KSR1; kinase suppressor of Ras 1" }, { "name":"102924578 Ksr2; (RefSeq) kinase suppressor of Ras 2 isoform X2\tK18529 KSR2; kinase suppressor of Ras 2 [EC:2.7.11.1]" } ] }, { "name":"RIPK family [OT]", "children":[ { "name":"102918287 Ripk1; (RefSeq) receptor-interacting serine\/threonine-protein kinase 1\tK02861 RIPK1; receptor-interacting serine\/threonine-protein kinase 1 [EC:2.7.11.1]" }, { "name":"102918587 Ripk2; (RefSeq) receptor-interacting serine\/threonine-protein kinase 2 isoform X1\tK08846 RIPK2; receptor-interacting serine\/threonine-protein kinase 2 [EC:2.7.11.1]" }, { "name":"102918456 Ripk4; (RefSeq) receptor-interacting serine\/threonine-protein kinase 4 isoform X1\tK08848 RIPK4; receptor-interacting serine\/threonine-protein kinase 4 [EC:2.7.11.1]" }, { "name":"102912409 Ankk1; (RefSeq) ankyrin repeat and protein kinase domain-containing protein 1 isoform X2\tK16289 ANKK1; ankyrin repeat and protein kinase domain-containing protein 1 [EC:2.7.11.1]" } ] }, { "name":"Other" } ] }, { "name":"Serine\/threonine kinases: Other", "children":[ { "name":"RGC family [OT]", "children":[ { "name":"102922973 Npr1; (RefSeq) atrial natriuretic peptide receptor 1\tK12323 NPR1; atrial natriuretic peptide receptor 1 [EC:4.6.1.2]" }, { "name":"102920250 Npr2; (RefSeq) atrial natriuretic peptide receptor 2 isoform X1\tK12324 NPR2; atrial natriuretic peptide receptor 2 [EC:4.6.1.2]" }, { "name":"102921015 Gucy2c; (RefSeq) guanylyl cyclase C\tK12320 GUCY2C; heat-stable enterotoxin receptor [EC:4.6.1.2]" }, { "name":"102906219 guanylate cyclase D\tK12321 GUCY2D_E; guanylate cyclase 2D\/E [EC:4.6.1.2]" }, { "name":"102926775 Gucy2d; (RefSeq) retinal guanylyl cyclase 1\tK12321 GUCY2D_E; guanylate cyclase 2D\/E [EC:4.6.1.2]" }, { "name":"102911030 Gucy2f; (RefSeq) retinal guanylyl cyclase 2\tK12322 GUCY2F; guanylate cyclase 2F [EC:4.6.1.2]" } ] }, { "name":"BUB family", "children":[ { "name":"102914886 Bub1; (RefSeq) mitotic checkpoint serine\/threonine-protein kinase BUB1 isoform X1\tK02178 BUB1; checkpoint serine\/threonine-protein kinase [EC:2.7.11.1]" }, { "name":"102921947 Bub1b; (RefSeq) mitotic checkpoint serine\/threonine-protein kinase BUB1 beta isoform X3\tK06637 BUB1B; mitotic checkpoint serine\/threonine-protein kinase BUB1 beta [EC:2.7.11.1]" } ] }, { "name":"Bud32 family", "children":[ { "name":"102924190 EKC\/KEOPS complex subunit Tp53rkb\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]" }, { "name":"143273066 Tp53rk; (RefSeq) EKC\/KEOPS complex subunit TP53RK\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]" } ] }, { "name":"CAMKK family", "children":[ { "name":"102923876 Camkk1; (RefSeq) calcium\/calmodulin-dependent protein kinase kinase 1 isoform X1\tK00908 CAMKK1; calcium\/calmodulin-dependent protein kinase kinase 1 [EC:2.7.11.17]" }, { "name":"102913974 Camkk2; (RefSeq) calcium\/calmodulin-dependent protein kinase kinase 2 isoform X1\tK07359 CAMKK2; calcium\/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]" } ] }, { "name":"CDC7 family", "children":[ { "name":"102914558 Cdc7; (RefSeq) cell division cycle 7-related protein kinase\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]" } ] }, { "name":"CK2 family", "children":[ { "name":"102912870 Csnk2a2; (RefSeq) casein kinase II subunit alpha' isoform X1\tK03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]" }, { "name":"102926740 Csnk2a1; (RefSeq) LOW QUALITY PROTEIN: casein kinase II subunit alpha\tK03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]" } ] }, { "name":"Haspin family" }, { "name":"IKK family [OT]", "children":[ { "name":"102914771 Chuk; (RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1\tK04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]" }, { "name":"102911820 Ikbkb; (RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta\tK07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]" }, { "name":"102918216 Ikbkg; (RefSeq) NF-kappa-B essential modulator isoform X1\tK07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma" }, { "name":"102917403 Ikbke; (RefSeq) inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2\tK07211 IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]" }, { "name":"102913039 Tbk1; (RefSeq) serine\/threonine-protein kinase TBK1\tK05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]" } ] }, { "name":"IRE family", "children":[ { "name":"102922509 Ern1; (RefSeq) serine\/threonine-protein kinase\/endoribonuclease IRE1\tK08852 ERN1; serine\/threonine-protein kinase\/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]" }, { "name":"102919799 Ern2; (RefSeq) serine\/threonine-protein kinase\/endoribonuclease IRE2\tK11715 ERN2; serine\/threonine-protein kinase\/endoribonuclease IRE2 [EC:2.7.11.1 3.1.26.-]" } ] }, { "name":"MOS family", "children":[ { "name":"102917198 Mos; (RefSeq) proto-oncogene serine\/threonine-protein kinase mos\tK04367 MOS; proto-oncogene serine\/threonine-protein kinase mos [EC:2.7.11.1]" } ] }, { "name":"NAK family [OT]", "children":[ { "name":"102918698 Aak1; (RefSeq) AP2-associated protein kinase 1 isoform X9\tK08853 AAK; AP2-associated kinase [EC:2.7.11.1]" }, { "name":"102925150 Bmp2k; (RefSeq) BMP-2-inducible protein kinase isoform X2\tK08854 BMP2K; BMP2 inducible kinase [EC:2.7.11.1]" }, { "name":"102906843 Gak; (RefSeq) cyclin-G-associated kinase isoform X3\tK08855 GAK; cyclin G-associated kinase [EC:2.7.11.1]" }, { "name":"102902955 Stk16; (RefSeq) serine\/threonine-protein kinase 16\tK08856 STK16; serine\/threonine kinase 16 [EC:2.7.11.1]" } ] }, { "name":"NEK family", "children":[ { "name":"102904339 Nek5; (RefSeq) serine\/threonine-protein kinase Nek5 isoform X3\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"102904862 Nek4; (RefSeq) serine\/threonine-protein kinase Nek4\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"102925834 Nek1; (RefSeq) serine\/threonine-protein kinase Nek1 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]" }, { "name":"102903287 Nek2; (RefSeq) serine\/threonine-protein kinase Nek2\tK20872 NEK2; serine\/threonine-protein kinase Nek2 [EC:2.7.11.1]" }, { "name":"102919000 Nek3; (RefSeq) serine\/threonine-protein kinase Nek3 isoform X1\tK20873 NEK3; serine\/threonine-protein kinase Nek3 [EC:2.7.11.1]" }, { "name":"102924906 Nek6; (RefSeq) serine\/threonine-protein kinase Nek6 isoform X1\tK20875 NEK6; serine\/threonine-protein kinase Nek6 [EC:2.7.11.34]" }, { "name":"102906726 Nek7; (RefSeq) serine\/threonine-protein kinase Nek7 isoform X2\tK20876 NEK7; serine\/threonine-protein kinase Nek7 [EC:2.7.11.34]" }, { "name":"102927911 Nek8; (RefSeq) serine\/threonine-protein kinase Nek8 isoform X3\tK20877 NEK8; serine\/threonine-protein kinase Nek8 [EC:2.7.11.1]" }, { "name":"102918892 Nek9; (RefSeq) serine\/threonine-protein kinase Nek9\tK20878 NEK9; serine\/threonine-protein kinase Nek9 [EC:2.7.11.38]" }, { "name":"102923283 Nek10; (RefSeq) serine\/threonine-protein kinase Nek10 isoform X2\tK20879 NEK10; serine\/threonine-protein kinase Nek10 [EC:2.7.11.1]" }, { "name":"102903018 Nek11; (RefSeq) serine\/threonine-protein kinase Nek11 isoform X1\tK20880 NEK11; serine\/threonine-protein kinase Nek11 [EC:2.7.11.1]" } ] }, { "name":"NKF1 family", "children":[ { "name":"102906870 Sbk2; (RefSeq) serine\/threonine-protein kinase SBK2\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" }, { "name":"102910994 Sbk1; (RefSeq) serine\/threonine-protein kinase SBK1\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" }, { "name":"102914578 Sbk3; (RefSeq) putative serine\/threonine-protein kinase SBK3\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]" } ] }, { "name":"NKF2 family", "children":[ { "name":"102904662 Pink1; (RefSeq) serine\/threonine-protein kinase PINK1, mitochondrial\tK05688 PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]" } ] }, { "name":"NKF3 family", "children":[ { "name":"102907401 Prag1; (RefSeq) inactive tyrosine-protein kinase PRAG1 isoform X2\tK17537 SGK223; tyrosine-protein kinase SgK223 [EC:2.7.10.2]" }, { "name":"102916255 Peak1; (RefSeq) inactive tyrosine-protein kinase PEAK1\tK17538 PEAK1; pseudopodium-enriched atypical kinase 1 [EC:2.7.10.2]" } ] }, { "name":"NKF4 family", "children":[ { "name":"102924652 Stk35; (RefSeq) serine\/threonine-protein kinase 35 isoform X1\tK08859 STK35; serine\/threonine kinase 35 [EC:2.7.11.1]" }, { "name":"102912850 Pdik1l; (RefSeq) serine\/threonine-protein kinase PDIK1L\tK17539 PDIK1L; serine\/threonine-protein kinase PDIK1L [EC:2.7.11.1]" } ] }, { "name":"NKF5 family", "children":[ { "name":"102926223 Tex14; (RefSeq) inactive serine\/threonine-protein kinase TEX14 isoform X1\tK17540 TEX14; inactive serine\/threonine-protein kinase TEX14" } ] }, { "name":"NRBP family", "children":[ { "name":"102908372 Nrbp2; (RefSeq) nuclear receptor-binding protein 2 isoform X2\tK08875 NRBP; nuclear receptor-binding protein" }, { "name":"102920907 Nrbp1; (RefSeq) nuclear receptor-binding protein isoform X3\tK08875 NRBP; nuclear receptor-binding protein" } ] }, { "name":"PEK family [OT]", "children":[ { "name":"102909504 Eif2ak1; (RefSeq) eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3\tK16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]" }, { "name":"102904928 Eif2ak3; (RefSeq) eukaryotic translation initiation factor 2-alpha kinase 3\tK08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]" }, { "name":"102922567 Eif2ak4; (RefSeq) eIF-2-alpha kinase GCN2 isoform X1\tK16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]" } ] }, { "name":"PLK family [OT]", "children":[ { "name":"102903310 Plk1; (RefSeq) serine\/threonine-protein kinase PLK1\tK06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]" }, { "name":"102906522 Plk2; (RefSeq) serine\/threonine-protein kinase PLK2\tK08861 PLK2; polo-like kinase 2 [EC:2.7.11.21]" }, { "name":"102903368 Plk3; (RefSeq) serine\/threonine-protein kinase PLK3\tK08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]" }, { "name":"102921977 Plk4; (RefSeq) serine\/threonine-protein kinase PLK4 isoform X1\tK08863 PLK4; polo-like kinase 4 [EC:2.7.11.21]" } ] }, { "name":"SCY1 family [OT]", "children":[ { "name":"102915168 Scyl1; (RefSeq) N-terminal kinase-like protein isoform X1\tK08876 SCYL1; SCY1-like protein 1" }, { "name":"102907649 Scyl2; (RefSeq) SCY1-like protein 2 isoform X1\tK17541 SCYL2; SCY1-like protein 2" }, { "name":"102907198 Scyl3; (RefSeq) protein-associating with the carboxyl-terminal domain of ezrin isoform X1\tK17542 SCYL3; SCY1-like protein 3" } ] }, { "name":"Slob family", "children":[ { "name":"102921109 Pxk; (RefSeq) PX domain-containing protein kinase-like protein isoform X1\tK17543 PXK; PX domain-containing protein kinase-like protein" } ] }, { "name":"TBCK family", "children":[ { "name":"102928645 Tbck; (RefSeq) TBC domain-containing protein kinase-like protein isoform X1\tK17544 TBCK; TBC domain-containing protein kinase-like protein" } ] }, { "name":"TLK family", "children":[ { "name":"102903350 Tlk2; (RefSeq) serine\/threonine-protein kinase tousled-like 2 isoform X1\tK08864 TLK; tousled-like kinase [EC:2.7.11.1]" }, { "name":"102927676 Tlk1; (RefSeq) serine\/threonine-protein kinase tousled-like 1\tK08864 TLK; tousled-like kinase [EC:2.7.11.1]" } ] }, { "name":"TOPK family", "children":[ { "name":"102905403 Pbk; (RefSeq) lymphokine-activated killer T-cell-originated protein kinase\tK08865 PBK; PDZ-binding kinase [EC:2.7.12.2]" } ] }, { "name":"TTK family", "children":[ { "name":"102909411 Ttk; (RefSeq) dual specificity protein kinase TTK isoform X3\tK08866 TTK; serine\/threonine-protein kinase TTK\/MPS1 [EC:2.7.12.1]" } ] }, { "name":"ULK family [OT]", "children":[ { "name":"102910414 Stk36; (RefSeq) serine\/threonine-protein kinase 36 isoform X2\tK06228 FU; fused [EC:2.7.11.1]" }, { "name":"102926323 Ulk1; (RefSeq) serine\/threonine-protein kinase ULK1 isoform X1\tK21357 ULK1; serine\/threonine-protein kinase ULK1 [EC:2.7.11.1]" }, { "name":"102903567 Ulk2; (RefSeq) serine\/threonine-protein kinase ULK2\tK08269 ULK2; serine\/threonine-protein kinase ULK2 [EC:2.7.11.1]" }, { "name":"102909758 Ulk3; (RefSeq) serine\/threonine-protein kinase ULK3 isoform X1\tK21358 ULK3; serine\/threonine-protein kinase ULK3 [EC:2.7.11.1]" }, { "name":"102916843 Ulk4; (RefSeq) serine\/threonine-protein kinase ULK4 isoform X1\tK17545 ULK4; serine\/threonine-protein kinase ULK4 [EC:2.7.11.1]" } ] }, { "name":"VPS15 family", "children":[ { "name":"102903931 Pik3r4; (RefSeq) phosphoinositide 3-kinase regulatory subunit 4\tK08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]" } ] }, { "name":"WEE family", "children":[ { "name":"102910542 Pkmyt1; (RefSeq) membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase\tK06633 PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]" }, { "name":"102924749 Wee1; (RefSeq) wee1-like protein kinase isoform X1\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]" }, { "name":"102927505 Wee2; (RefSeq) wee1-like protein kinase 2 isoform X1\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]" } ] }, { "name":"Wnk family", "children":[ { "name":"102907562 Wnk1; (RefSeq) serine\/threonine-protein kinase WNK1 isoform X14\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" }, { "name":"102909029 Wnk4; (RefSeq) serine\/threonine-protein kinase WNK4 isoform X3\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" }, { "name":"102915748 Wnk3; (RefSeq) serine\/threonine-protein kinase WNK3 isoform X1\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" }, { "name":"102927673 Wnk2; (RefSeq) serine\/threonine-protein kinase WNK2 isoform X1\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]" } ] }, { "name":"ABC1 family", "children":[ { "name":"102907293 Coq8a; (RefSeq) atypical kinase COQ8A, mitochondrial\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"102920655 Adck5; (RefSeq) putative aarF domain-containing protein kinase 5\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"102921516 Coq8b; (RefSeq) atypical kinase COQ8B, mitochondrial\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"102924796 Adck2; (RefSeq) putative aarF domain-containing protein kinase 2 isoform X1\tK08869 ADCK; aarF domain-containing kinase" }, { "name":"102925206 Adck1; (RefSeq) aarF domain-containing protein kinase 1\tK08869 ADCK; aarF domain-containing kinase" } ] }, { "name":"Alpha family [OT]", "children":[ { "name":"102908912 Alpk3; (RefSeq) alpha-protein kinase 3 isoform X1\tK08868 ALPK; alpha-kinase" }, { "name":"102926656 Alpk1; (RefSeq) alpha-protein kinase 1 isoform X1\tK08868 ALPK; alpha-kinase" }, { "name":"102924032 Trpm6; (RefSeq) transient receptor potential cation channel subfamily M member 6 isoform X2\tK04981 TRPM6; transient receptor potential cation channel subfamily M member 6 [EC:2.7.11.1]" }, { "name":"102919927 Trpm7; (RefSeq) transient receptor potential cation channel subfamily M member 7 isoform X1\tK04982 TRPM7; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1]" }, { "name":"102923517 Eef2k; (RefSeq) eukaryotic elongation factor 2 kinase isoform X1\tK08292 EEF2K; elongation factor 2 kinase [EC:2.7.11.20]" } ] }, { "name":"BCR family", "children":[ { "name":"102907645 Bcr; (RefSeq) breakpoint cluster region protein\tK08878 BCR1; breakpoint cluster region protein [EC:2.7.11.1]" } ] }, { "name":"BRD family [OT]", "children":[ { "name":"102914418 Brd2; (RefSeq) bromodomain-containing protein 2 isoform X1\tK08871 BRD2; bromodomain-containing protein 2" }, { "name":"102915739 Brd3; (RefSeq) bromodomain-containing protein 3 isoform X1\tK11721 BRD3; bromodomain-containing protein 3" }, { "name":"102911438 Brd4; (RefSeq) bromodomain-containing protein 4 isoform X3\tK11722 BRD4; bromodomain-containing protein 4" }, { "name":"102913729 Brdt; (RefSeq) bromodomain testis-specific protein isoform X19\tK11724 BRDT; bromodomain testis-specific protein" } ] }, { "name":"FAST family", "children":[ { "name":"102922447 Fastk; (RefSeq) fas-activated serine\/threonine kinase isoform X2\tK08290 FASTK; Fas-activated serine\/threonine kinase [EC:2.7.11.8]" } ] }, { "name":"G11 family", "children":[ { "name":"102910839 Whr1; (RefSeq) winged helix repair factor 1 isoform X2\tK08880 STK19; serine\/threonine kinase 19 [EC:2.7.11.1]" } ] }, { "name":"H11 family", "children":[ { "name":"102911747 Hspb8; (RefSeq) heat shock protein beta-8\tK08879 HSPB8; heat shock protein beta-8" } ] }, { "name":"PDHK family [OT]", "children":[ { "name":"102905642 Pdk1; (RefSeq) pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1\tK12077 PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]" }, { "name":"102909322 Pdk3; (RefSeq) pyruvate dehydrogenase kinase, isozyme 3 isoform X2\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" }, { "name":"102912512 Pdk2; (RefSeq) pyruvate dehydrogenase kinase, isozyme 2 isoform X1\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" }, { "name":"102914054 Pdk4; (RefSeq) pyruvate dehydrogenase kinase, isozyme 4\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]" }, { "name":"102926491 Bckdk; (RefSeq) branched-chain alpha-ketoacid dehydrogenase kinase isoform X1\tK00905 BCKDK; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase [EC:2.7.11.4]" } ] }, { "name":"PIKK family [OT]", "children":[ { "name":"102914177 Atm; (RefSeq) serine-protein kinase ATM isoform X1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]" }, { "name":"102915132 Atr; (RefSeq) serine\/threonine-protein kinase ATR isoform X1\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]" }, { "name":"102909047 Mtor; (RefSeq) serine\/threonine-protein kinase mTOR\tK07203 MTOR; serine\/threonine-protein kinase mTOR [EC:2.7.11.1]" }, { "name":"102914938 Prkdc; (RefSeq) DNA-dependent protein kinase catalytic subunit isoform X1\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]" }, { "name":"102913215 Smg1; (RefSeq) serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"102912370 Trrap; (RefSeq) transformation\/transcription domain-associated protein isoform X10\tK08874 TRRAP; transformation\/transcription domain-associated protein" } ] }, { "name":"RIO family [OT]", "children":[ { "name":"102918630 Riok1; (RefSeq) serine\/threonine-protein kinase RIO1 isoform X1\tK07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]" }, { "name":"102926794 Riok2; (RefSeq) serine\/threonine-protein kinase RIO2\tK07179 RIOK2; RIO kinase 2 [EC:2.7.11.1]" }, { "name":"102925303 Riok3; (RefSeq) serine\/threonine-protein kinase RIO3 isoform X2\tK08872 RIOK3; RIO kinase 3 [EC:2.7.11.1]" } ] }, { "name":"TAF1 family", "children":[ { "name":"102908039 Taf1; (RefSeq) transcription initiation factor TFIID subunit 1 isoform X1\tK03125 TAF1; transcription initiation factor TFIID subunit 1 [EC:2.3.1.48 2.7.11.1]" }, { "name":"102928331 Ciita; (RefSeq) MHC class II transactivator isoform X1\tK08060 CIITA; MHC class II transactivator [EC:2.7.11.1]" } ] }, { "name":"TIF1 family [OT]", "children":[ { "name":"102907066 Trim24; (RefSeq) transcription intermediary factor 1-alpha isoform X1\tK08881 TRIM24; tripartite motif-containing protein 24 [EC:2.3.2.27]" }, { "name":"143272566 LOW QUALITY PROTEIN: transcription intermediary factor 1-alpha-like\tK08881 TRIM24; tripartite motif-containing protein 24 [EC:2.3.2.27]" }, { "name":"143272753 LOW QUALITY PROTEIN: transcription intermediary factor 1-alpha-like\tK08881 TRIM24; tripartite motif-containing protein 24 [EC:2.3.2.27]" }, { "name":"102923301 Trim28; (RefSeq) transcription intermediary factor 1-beta\tK08882 TRIM28; tripartite motif-containing protein 28 [EC:2.3.2.27]" }, { "name":"102909087 Trim33; (RefSeq) E3 ubiquitin-protein ligase TRIM33 isoform X2\tK08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]" } ] }, { "name":"Other", "children":[ { "name":"102914804 Uhmk1; (RefSeq) serine\/threonine-protein kinase Kist isoform X1\tK08877 UHMK1; serine\/threonine-protein kinase Kist [EC:2.7.11.1]" }, { "name":"102910350 DDB1- and CUL4-associated factor 1-like isoform X1\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"102910979 Dcaf1; (RefSeq) DDB1- and CUL4-associated factor 1 isoform X1\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"102924357 DDB1- and CUL4-associated factor 1-like isoform X1\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"143269686 DDB1- and CUL4-associated factor 1-like isoform X1\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"143269687 LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1-like\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"143269688 DDB1- and CUL4-associated factor 1-like isoform X1\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]" }, { "name":"102903240 Stk31; (RefSeq) serine\/threonine-protein kinase 31 isoform X1\tK16316 STK31; serine\/threonine-protein kinase 31 [EC:2.7.11.1]" }, { "name":"102921860 Pomk; (RefSeq) protein O-mannose kinase isoform X1\tK17547 SGK196; glycoprotein-mannosyl O6-kinase [EC:2.7.1.183]" }, { "name":"102914773 Dstyk; (RefSeq) dual serine\/threonine and tyrosine protein kinase\tK16288 DSTYK; dual serine\/threonine and tyrosine protein kinase [EC:2.7.12.1]" }, { "name":"102919753 Stkld1; (RefSeq) serine\/threonine kinase-like domain-containing protein STKLD1 isoform X1\tK17546 STKLD1; serine\/threonine kinase-like domain-containing protein STKLD1" } ] }, { "name":"Bacterial family" } ] }, { "name":"Receptor serine\/threonine kinases (RSTK): TKL group", "children":[ { "name":"TGFBR1 family [OT]", "children":[ { "name":"102914144 Acvr1; (RefSeq) activin receptor type-1\tK04675 ACVR1; activin receptor type-1 [EC:2.7.11.30]" }, { "name":"102927636 Acvrl1; (RefSeq) activin receptor type-1-like isoform X1\tK13594 ACVRL1; activin receptor-like kinase 1 [EC:2.7.11.30]" }, { "name":"102927129 Acvr1b; (RefSeq) activin receptor type-1B isoform X1\tK13567 ACVR1B; activin receptor type-1B [EC:2.7.11.30]" }, { "name":"102914460 Acvr1c; (RefSeq) activin receptor type-1C\tK13568 ACVR1C; activin receptor type-1C [EC:2.7.11.30]" }, { "name":"102903396 Bmpr1a; (RefSeq) bone morphogenetic protein receptor type-1A\tK04673 BMPR1A; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]" }, { "name":"102908258 Bmpr1b; (RefSeq) bone morphogenetic protein receptor type-1B isoform X1\tK13578 BMPR1B; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]" }, { "name":"102918336 Tgfbr1; (RefSeq) TGF-beta receptor type-1 isoform X1\tK04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]" } ] }, { "name":"TGFBR2 family [OT]", "children":[ { "name":"102907294 Acvr2a; (RefSeq) activin receptor type-2A\tK04670 ACVR2A; activin receptor type-2A [EC:2.7.11.30]" }, { "name":"102925612 Acvr2b; (RefSeq) activin receptor type-2B isoform X1\tK13596 ACVR2B; activin receptor type-2B [EC:2.7.11.30]" }, { "name":"102908881 Amhr2; (RefSeq) anti-Muellerian hormone type-2 receptor isoform X2\tK04672 AMHR2; anti-mullerian hormone receptor type-2 [EC:2.7.11.30]" }, { "name":"102917833 Bmpr2; (RefSeq) bone morphogenetic protein receptor type-2\tK04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]" }, { "name":"102919736 Tgfbr2; (RefSeq) TGF-beta receptor type-2 isoform X1\tK04388 TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]" } ] } ] }, { "name":"Receptor tyrosine kinases (RTK)", "children":[ { "name":"EGFR family [OT]", "children":[ { "name":"102910428 Egfr; (RefSeq) epidermal growth factor receptor isoform X1\tK04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]" }, { "name":"102909538 Erbb2; (RefSeq) receptor tyrosine-protein kinase erbB-2\tK05083 ERBB2; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]" }, { "name":"102907967 Erbb3; (RefSeq) receptor tyrosine-protein kinase erbB-3\tK05084 ERBB3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]" }, { "name":"102906037 Erbb4; (RefSeq) receptor tyrosine-protein kinase erbB-4 isoform X3\tK05085 ERBB4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]" } ] }, { "name":"INSR family [OT]", "children":[ { "name":"102914518 Insrr; (RefSeq) insulin receptor-related protein\tK05086 INSRR; insulin receptor-related receptor [EC:2.7.10.1]" }, { "name":"102928259 Insr; (RefSeq) insulin receptor isoform X1\tK04527 INSR; insulin receptor [EC:2.7.10.1]" }, { "name":"102917869 Igf1r; (RefSeq) insulin-like growth factor 1 receptor isoform X1\tK05087 IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]" } ] }, { "name":"PDGFR family [OT]", "children":[ { "name":"102927320 Pdgfra; (RefSeq) platelet-derived growth factor receptor alpha\tK04363 PDGFRA; platelet-derived growth factor receptor alpha [EC:2.7.10.1]" }, { "name":"102915075 Pdgfrb; (RefSeq) platelet-derived growth factor receptor beta isoform X2\tK05089 PDGFRB; platelet-derived growth factor receptor beta [EC:2.7.10.1]" }, { "name":"102915389 Csf1r; (RefSeq) macrophage colony-stimulating factor 1 receptor isoform X2\tK05090 CSF1R; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]" }, { "name":"102927627 Kit; (RefSeq) mast\/stem cell growth factor receptor Kit isoform X1\tK05091 KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]" }, { "name":"102923705 Flt3; (RefSeq) receptor-type tyrosine-protein kinase FLT3 isoform X1\tK05092 FLT3; fms-related tyrosine kinase 3 [EC:2.7.10.1]" } ] }, { "name":"FGFR family [OT]", "children":[ { "name":"102925907 Fgfr1; (RefSeq) fibroblast growth factor receptor 1 isoform X3\tK04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]" }, { "name":"102917623 Fgfr2; (RefSeq) fibroblast growth factor receptor 2 isoform X2\tK05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]" }, { "name":"102922831 Fgfr3; (RefSeq) fibroblast growth factor receptor 3 isoform X2\tK05094 FGFR3; fibroblast growth factor receptor 3 [EC:2.7.10.1]" }, { "name":"102911071 Fgfr4; (RefSeq) fibroblast growth factor receptor 4\tK05095 FGFR4; fibroblast growth factor receptor 4 [EC:2.7.10.1]" } ] }, { "name":"VEGFR family [OT]", "children":[ { "name":"102922878 Flt1; (RefSeq) vascular endothelial growth factor receptor 1\tK05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]" }, { "name":"102924470 Flt4; (RefSeq) vascular endothelial growth factor receptor 3\tK05097 FLT4; FMS-like tyrosine kinase 4 [EC:2.7.10.1]" }, { "name":"102928719 Kdr; (RefSeq) vascular endothelial growth factor receptor 2 isoform X1\tK05098 KDR; kinase insert domain protein receptor [EC:2.7.10.1]" } ] }, { "name":"MET family", "children":[ { "name":"102921464 Met; (RefSeq) hepatocyte growth factor receptor isoform X1\tK05099 MET; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]" }, { "name":"102927310 Mst1r; (RefSeq) macrophage-stimulating protein receptor isoform X1\tK05100 MST1R; macrophage-stimulating 1 receptor [EC:2.7.10.1]" } ] }, { "name":"TRK family [OT]", "children":[ { "name":"102914200 Ntrk1; (RefSeq) high affinity nerve growth factor receptor isoform X1\tK03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]" }, { "name":"102914134 Ntrk2; (RefSeq) BDNF\/NT-3 growth factors receptor isoform X1\tK04360 NTRK2; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]" }, { "name":"102925829 Ntrk3; (RefSeq) NT-3 growth factor receptor isoform X1\tK05101 NTRK3; neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]" } ] }, { "name":"EPH family [OT]", "children":[ { "name":"102903701 Epha1; (RefSeq) ephrin type-A receptor 1\tK05102 EPHA1; Eph receptor A1 [EC:2.7.10.1]" }, { "name":"102911161 Epha2; (RefSeq) ephrin type-A receptor 2 isoform X2\tK05103 EPHA2; Eph receptor A2 [EC:2.7.10.1]" }, { "name":"102918072 Epha3; (RefSeq) ephrin type-A receptor 3\tK05104 EPHA3; Eph receptor A3 [EC:2.7.10.1]" }, { "name":"102921493 Epha4; (RefSeq) ephrin type-A receptor 4 isoform X1\tK05105 EPHA4; Eph receptor A4 [EC:2.7.10.1]" }, { "name":"102925600 Epha5; (RefSeq) ephrin type-A receptor 5 isoform X1\tK05106 EPHA5; Eph receptor A5 [EC:2.7.10.1]" }, { "name":"102916211 Epha6; (RefSeq) ephrin type-A receptor 6\tK05107 EPHA6; Eph receptor A6 [EC:2.7.10.1]" }, { "name":"102910082 Epha7; (RefSeq) ephrin type-A receptor 7 isoform X1\tK05108 EPHA7; EphA7 [EC:2.7.10.1]" }, { "name":"102917763 Epha8; (RefSeq) ephrin type-A receptor 8 isoform X1\tK05109 EPHA8; Eph receptor A8 [EC:2.7.10.1]" }, { "name":"102919590 Epha10; (RefSeq) ephrin type-A receptor 10\tK08897 EPHA10; Eph receptor A10 [EC:2.7.10.1]" }, { "name":"102927721 Ephb1; (RefSeq) ephrin type-B receptor 1\tK05110 EPHB1; Eph receptor B1 [EC:2.7.10.1]" }, { "name":"102919800 Ephb2; (RefSeq) ephrin type-B receptor 2 isoform X1\tK05111 EPHB2; Eph receptor B2 [EC:2.7.10.1]" }, { "name":"102910384 Ephb3; (RefSeq) ephrin type-B receptor 3\tK05112 EPHB3; Eph receptor B3 [EC:2.7.10.1]" }, { "name":"102903357 Ephb4; (RefSeq) ephrin type-B receptor 4\tK05113 EPHB4; Eph receptor B4 [EC:2.7.10.1]" }, { "name":"102924535 Ephb6; (RefSeq) ephrin type-B receptor 6 isoform X1\tK05114 EPHB6; Eph receptor B6 [EC:2.7.10.1]" } ] }, { "name":"AXL family", "children":[ { "name":"102927856 Axl; (RefSeq) tyrosine-protein kinase receptor UFO isoform X1\tK05115 AXL; AXL receptor tyrosine kinase [EC:2.7.10.1]" }, { "name":"102904173 Tyro3; (RefSeq) tyrosine-protein kinase receptor TYRO3 isoform X1\tK05116 TYRO3; TYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]" }, { "name":"102912192 Mertk; (RefSeq) tyrosine-protein kinase Mer\tK05117 MERTK; c-mer proto-oncogene tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"ALK family", "children":[ { "name":"102918821 Alk; (RefSeq) ALK tyrosine kinase receptor isoform X1\tK05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]" }, { "name":"102909122 Ltk; (RefSeq) leukocyte tyrosine kinase receptor isoform X3\tK05118 LTK; leukocyte tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"TIE family", "children":[ { "name":"102923580 Tie1; (RefSeq) tyrosine-protein kinase receptor Tie-1\tK05120 TIE1; tyrosine kinase receptor 1 [EC:2.7.10.1]" }, { "name":"102927080 Tek; (RefSeq) angiopoietin-1 receptor isoform X1\tK05121 TEK; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"ROR family", "children":[ { "name":"102910525 Ror1; (RefSeq) inactive tyrosine-protein kinase transmembrane receptor ROR1\tK05122 ROR1; receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1]" }, { "name":"102920504 Ror2; (RefSeq) tyrosine-protein kinase transmembrane receptor ROR2\tK05123 ROR2; receptor tyrosine kinase-like orphan receptor 2 [EC:2.7.10.1]" } ] }, { "name":"DDR family", "children":[ { "name":"102927406 Ddr1; (RefSeq) epithelial discoidin domain-containing receptor 1 isoform X1\tK05124 DDR1; discoidin domain receptor family member 1 [EC:2.7.10.1]" }, { "name":"102915122 Ddr2; (RefSeq) discoidin domain-containing receptor 2 isoform X2\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]" } ] }, { "name":"RET family", "children":[ { "name":"102928076 Ret; (RefSeq) proto-oncogene tyrosine-protein kinase receptor Ret isoform X2\tK05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]" } ] }, { "name":"ROS family", "children":[ { "name":"102922135 Ros1; (RefSeq) proto-oncogene tyrosine-protein kinase ROS isoform X3\tK05088 ROS1; proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1]" } ] }, { "name":"CCK family", "children":[ { "name":"102915927 Ptk7; (RefSeq) inactive tyrosine-protein kinase 7 isoform X2\tK05127 PTK7; PTK7 protein tyrosine kinase 7 [EC:2.7.10.1]" } ] }, { "name":"RYK family", "children":[ { "name":"102922996 Ryk; (RefSeq) tyrosine-protein kinase RYK isoform X2\tK05128 RYK; RYK receptor-like tyrosine kinase [EC:2.7.10.1]" } ] }, { "name":"MUSK family" }, { "name":"LMR family [OT]", "children":[ { "name":"102924882 Aatk; (RefSeq) serine\/threonine-protein kinase LMTK1 isoform X1\tK17480 AATK; lemur tyrosine kinase 1 [EC:2.7.10.1]" }, { "name":"102920844 Lmtk2; (RefSeq) serine\/threonine-protein kinase LMTK2 isoform X1\tK08898 LMTK2; lemur tyrosine kinase 2 [EC:2.7.10.1]" }, { "name":"102915998 Lmtk3; (RefSeq) serine\/threonine-protein kinase LMTK3 isoform X1\tK08899 LMTK3; lemur tyrosine kinase 3 [EC:2.7.10.1]" } ] } ] }, { "name":"Non-receptor tyrosine kinases", "children":[ { "name":"ABL family", "children":[ { "name":"102923329 Abl1; (RefSeq) tyrosine-protein kinase ABL1 isoform X1\tK06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]" }, { "name":"102929093 Abl2; (RefSeq) tyrosine-protein kinase ABL2 isoform X1\tK08887 ABL2; abelson tyrosine-protein kinase 2 [EC:2.7.10.2]" } ] }, { "name":"ACK family", "children":[ { "name":"102914394 Tnk1; (RefSeq) non-receptor tyrosine-protein kinase TNK1 isoform X1\tK08885 TNK1; non-receptor tyrosine-protein kinase TNK1 [EC:2.7.10.2]" }, { "name":"102905234 Tnk2; (RefSeq) activated CDC42 kinase 1 isoform X1\tK08886 TNK2; activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]" } ] }, { "name":"CSK family", "children":[ { "name":"102908605 Csk; (RefSeq) tyrosine-protein kinase CSK\tK05728 CSK; C-terminal Src kinase [EC:2.7.10.4]" }, { "name":"102915668 Matk; (RefSeq) megakaryocyte-associated tyrosine-protein kinase isoform X2\tK08888 MATK; megakaryocyte-associated tyrosine kinase [EC:2.7.10.2]" } ] }, { "name":"FAK family", "children":[ { "name":"102925932 Ptk2; (RefSeq) focal adhesion kinase 1 isoform X4\tK05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]" }, { "name":"102928849 Ptk2b; (RefSeq) protein-tyrosine kinase 2-beta isoform X2\tK05871 PTK2B; focal adhesion kinase 2 [EC:2.7.10.2]" } ] }, { "name":"FES family", "children":[ { "name":"102912390 Fes; (RefSeq) tyrosine-protein kinase Fes\/Fps isoform X1\tK07527 FES; tyrosine-protein kinase Fes\/Fps [EC:2.7.10.2]" }, { "name":"102927469 Fer; (RefSeq) tyrosine-protein kinase Fer isoform X2\tK08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]" } ] }, { "name":"JAK family [OT]", "children":[ { "name":"102911463 Jak1; (RefSeq) tyrosine-protein kinase JAK1\tK11217 JAK1; Janus kinase 1 [EC:2.7.10.2]" }, { "name":"102921378 Jak2; (RefSeq) tyrosine-protein kinase JAK2\tK04447 JAK2; Janus kinase 2 [EC:2.7.10.2]" }, { "name":"102905717 Jak3; (RefSeq) tyrosine-protein kinase JAK3\tK11218 JAK3; Janus kinase 3 [EC:2.7.10.2]" }, { "name":"102908684 Tyk2; (RefSeq) non-receptor tyrosine-protein kinase TYK2\tK11219 TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]" } ] }, { "name":"SRC family", "children":[ { "name":"102922232 Blk; (RefSeq) tyrosine-protein kinase Blk\tK08890 BLK; B lymphoid tyrosine kinase [EC:2.7.10.2]" }, { "name":"102927900 Fgr; (RefSeq) tyrosine-protein kinase Fgr\tK08891 FGR; tyrosine-protein kinase Fgr [EC:2.7.10.2]" }, { "name":"102909302 Frk; (RefSeq) tyrosine-protein kinase FRK\tK08892 FRK; fyn-related kinase [EC:2.7.10.2]" }, { "name":"102905501 Fyn; (RefSeq) tyrosine-protein kinase Fyn isoform X1\tK05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]" }, { "name":"102917664 Hck; (RefSeq) tyrosine-protein kinase HCK\tK08893 HCK; hemopoietic cell kinase [EC:2.7.10.2]" }, { "name":"102916368 Lyn; (RefSeq) tyrosine-protein kinase Lyn isoform X1\tK05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]" }, { "name":"102921821 Lck; (RefSeq) tyrosine-protein kinase Lck\tK05856 LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]" }, { "name":"102926981 Ptk6; (RefSeq) protein-tyrosine kinase 6 isoform X1\tK08894 PTK6; protein tyrosine kinase 6 [EC:2.7.10.2]" }, { "name":"102903223 Src; (RefSeq) proto-oncogene tyrosine-protein kinase Src isoform X1\tK05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]" }, { "name":"102926689 Srms; (RefSeq) tyrosine-protein kinase Srms isoform X1\tK08895 SRMS; tyrosine-protein kinase Srms [EC:2.7.10.2]" }, { "name":"102925295 LOW QUALITY PROTEIN: tyrosine-protein kinase Yes-like\tK05705 YES1; tyrosine-protein kinase Yes [EC:2.7.10.2]" }, { "name":"102928757 Yes1; (RefSeq) tyrosine-protein kinase Yes\tK05705 YES1; tyrosine-protein kinase Yes [EC:2.7.10.2]" } ] }, { "name":"TEC family", "children":[ { "name":"102919048 Bmx; (RefSeq) cytoplasmic tyrosine-protein kinase BMX isoform X1\tK08896 BMX; cytoplasmic tyrosine-protein kinase BMX [EC:2.7.10.2]" }, { "name":"102926843 Btk; (RefSeq) tyrosine-protein kinase BTK\tK07370 BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]" }, { "name":"102911797 Itk; (RefSeq) tyrosine-protein kinase ITK\/TSK isoform X1\tK07363 ITK; IL2-inducible T-cell kinase [EC:2.7.10.2]" }, { "name":"102919095 Tec; (RefSeq) tyrosine-protein kinase Tec isoform X1\tK07364 TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]" }, { "name":"102918572 Txk; (RefSeq) tyrosine-protein kinase TXK\tK08016 TXK; tyrosine-protein kinase TXK [EC:2.7.10.2]" } ] }, { "name":"SYK family", "children":[ { "name":"102921615 Syk; (RefSeq) tyrosine-protein kinase SYK isoform X1\tK05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]" }, { "name":"102923421 Zap70; (RefSeq) tyrosine-protein kinase ZAP-70 isoform X1\tK07360 ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]" } ] }, { "name":"Other", "children":[ { "name":"102921007 Styk1; (RefSeq) tyrosine-protein kinase STYK1 isoform X2\tK17510 STYK1; tyrosine-protein kinase STYK1 [EC:2.7.10.2]" }, { "name":"102909119 Pkdcc; (RefSeq) extracellular tyrosine-protein kinase PKDCC\tK17548 PKDCC; extracellular tyrosine-protein kinase PKDCC  [EC:2.7.10.2]" } ] }, { "name":"Bacterial" } ] }, { "name":"Histidine kinases", "children":[ { "name":"OmpR family" }, { "name":"NarL family" }, { "name":"Spo family [OT]" }, { "name":"CitB family [OT]" }, { "name":"LytTR family [OT]" }, { "name":"NtrC family" }, { "name":"CheA family [OT]" }, { "name":"Cell cycle family [OT]" }, { "name":"Lux family [OT]" }, { "name":"LuxR family [OT]" }, { "name":"Other" } ] } ] }