{
	"name":"pmeg01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"FNZ07_24430 GNAT family N-acetyltransferase\tK18816 aac6-I; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"FNZ07_17370 APH(6) family putative aminoglycoside O-phosphotransferase\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"FNZ07_11725 TCR\/Tet family MFS transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase",
				"children":[
				{
					"name":"FNZ07_07250 AAA family ATPase\tK18554 cpt; chloramphenicol 3-O phosphotransferase [EC:2.7.1.-]"
				}
				]
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases",
				"children":[
				{
					"name":"FNZ07_10935 dihydrofolate reductase\tK18590 dfrA12; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]"
				}
				]
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"FNZ07_21125 DUF3471 domain-containing protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"FNZ07_21130 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"FNZ07_21845 bla; class A beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"FNZ07_10255 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"FNZ07_11560 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"FNZ07_12665 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"FNZ07_10250 response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"FNZ07_11565 irlR; heavy metal response regulator transcription factor IrlR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"FNZ07_12670 response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"FNZ07_11375 ddpX; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"FNZ07_00970 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_03420 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_09155 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_12680 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_14115 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_16770 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_29890 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_00965 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"FNZ07_03415 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"FNZ07_09150 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"FNZ07_12685 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"FNZ07_14120 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"FNZ07_16765 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"FNZ07_29885 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"FNZ07_00975 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_03425 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_11665 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_14110 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_16775 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_17975 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_21335 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_21360 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_23290 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_26910 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_29880 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_33425 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"FNZ07_24135 efflux RND transporter periplasmic adaptor subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_24140 efflux RND transporter permease subunit\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"FNZ07_00975 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_03425 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_11665 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_14110 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_16775 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_17975 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_21335 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_21360 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_23290 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_26910 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_29880 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_33425 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"FNZ07_00975 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_03425 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_11665 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_14110 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_16775 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_17975 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_21335 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_21360 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_23290 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_26910 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_29880 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_33425 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"FNZ07_07530 LuxR family transcriptional regulator\tK18304 lasR; LuxR family transcriptional regulator, quorum-sensing system regulator LasR"
				},
				{
					"name":"FNZ07_07535 LuxR family transcriptional regulator\tK18304 lasR; LuxR family transcriptional regulator, quorum-sensing system regulator LasR"
				},
				{
					"name":"FNZ07_20025 cueR; Cu(I)-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"FNZ07_25770 MerR family transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"FNZ07_03105 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"FNZ07_11065 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"FNZ07_21535 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"FNZ07_23350 TolC family protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"FNZ07_03105 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"FNZ07_11065 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"FNZ07_21535 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"FNZ07_23350 TolC family protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"FNZ07_01715 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_02305 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_03900 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_09015 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_10220 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_10610 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_16860 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_17460 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"FNZ07_01705 efflux RND transporter periplasmic adaptor subunit\tK18901 bpeE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_01700 efflux RND transporter permease subunit\tK18902 bpeF; multidrug efflux pump"
				},
				{
					"name":"FNZ07_01695 efflux transporter outer membrane subunit\tK18903 oprC; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"FNZ07_12675 efflux transporter outer membrane subunit\tK18903 oprC; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}