{
	"name":"pox01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]",
				"children":[
				{
					"name":"MB84_23690 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase\tK19211 blaOXA-62; beta-lactamase class D OXA-62 [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"MB84_23135 aminoglycoside 6'-acetyltransferase\tK18816 aac6-I; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"MB84_13965 hypothetical protein\tK08160 mdfA; MFS transporter, DHA1 family, multidrug\/chloramphenicol efflux transport protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"MB84_00680 MFS transporter\tK18553 cmlR; MFS transporter, DHA1 family, chloramphenicol resistance protein"
				}
				]
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"MB84_09645 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"MB84_16230 two-component sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"MB84_16235 DNA-binding response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"MB84_03395 hypothetical protein\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"MB84_16245 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MB84_22735 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MB84_16250 RND transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MB84_22730 multidrug efflux RND transporter permease\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"MB84_11600 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_14985 MarR family transcriptional regulator\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_22725 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_23390 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_23740 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"MB84_17890 efflux transporter periplasmic adaptor subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MB84_17895 multidrug transporter AcrB\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"MB84_11600 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_14985 MarR family transcriptional regulator\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_22725 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_23390 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_23740 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"MB84_23400 efflux transporter periplasmic adaptor subunit\tK18094 mexX; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MB84_23395 multidrug efflux RND transporter permease\tK18095 mexY; multidrug efflux pump"
				},
				{
					"name":"MB84_11600 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_14985 MarR family transcriptional regulator\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_22725 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_23390 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_23740 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"MB84_07185 hypothetical protein\tK18304 lasR; LuxR family transcriptional regulator, quorum-sensing system regulator LasR"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"MB84_00745 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MB84_06005 hypothetical protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"MB84_00745 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"MB84_06005 hypothetical protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"MB84_18560 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"MB84_24985 hypothetical protein\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"MB84_18570 efflux transporter periplasmic adaptor subunit\tK18901 bpeE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"MB84_18575 multidrug efflux RND transporter permease subunit\tK18902 bpeF; multidrug efflux pump"
				},
				{
					"name":"MB84_16240 RND transporter\tK18903 oprC; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"MB84_18580 RND transporter\tK18903 oprC; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"MB84_09645 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}