{
	"name":"pxy04121",
	"children":[
	{
		"name":"Ubiquitins and ubiquitin-like proteins",
		"children":[
		{
			"name":"Ubiquitins",
			"children":[
			{
				"name":"105388041 LOC105388041; polyubiquitin-A\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"119693110 LOC119693110; polyubiquitin-C\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"105397135 RpL40; ribosomal protein L40\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"105381543 RpS27A; ribosomal protein S27A\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			}
			]
		},
		{
			"name":"Ubiquitin-like proteins (UBLs)",
			"children":[
			{
				"name":"105385873 Nedd8; nedd8 ubiquitin like modifier\tK12158 NEDD8; ubiquitin-like protein Nedd8"
			},
			{
				"name":"105398215 RpS30; ribosomal protein S30\tK02983 RP-S30e; small subunit ribosomal protein S30e"
			},
			{
				"name":"105396021 Sumo; small ubiquitin like modifier\tK12160 SUMO; small ubiquitin-related modifier"
			},
			{
				"name":"105386445 Atg8; autophagy related protein Atg8\tK08341 GABARAP; GABA(A) receptor-associated protein"
			},
			{
				"name":"105392873 Atg12; autophagy-related 12\tK08336 ATG12; ubiquitin-like protein ATG12"
			},
			{
				"name":"105396087 Urm1; ubiquitin-related modifier 1\tK12161 URM1; ubiquitin related modifier 1"
			},
			{
				"name":"105383506 UBL3; ubiquitin like 3 isoform X1\tK28515 UBL3; membrane-anchored ubiquitin-fold protein"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-activating enzymes (E1)",
		"children":[
		{
			"name":"Ubiquitin activating enzyme",
			"children":[
			{
				"name":"105384339 Uba1; ubiquitin-like activating enzyme 1\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			}
			]
		},
		{
			"name":"UBL-activating enzymes",
			"children":[
			{
				"name":"119690570 Aos1; SUMO1 activating enzyme subunit 1\tK10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]"
			},
			{
				"name":"105398117 Uba2; ubiquitin-like activating enzyme 2\tK10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]"
			},
			{
				"name":"105385156 Uba3; ubiquitin-like activating enzyme 3\tK10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]"
			},
			{
				"name":"105388247 APP-BP1; nedd8-activating enzyme E1 regulatory subunit APP-BP1\tK04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit"
			},
			{
				"name":"105395037 Uba5; ubiquitin-like activating enzyme 5\tK12164 UBA5; ubiquitin-like modifier-activating enzyme 5"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-conjugating enzymes (E2)",
		"children":[
		{
			"name":"Ubiquitin-conjugating enzymes",
			"children":[
			{
				"name":"105383376 Ubc6; ubiquitin conjugating enzyme 6\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
			},
			{
				"name":"105382461 vih; ubiquitin conjugating enzyme vih\tK06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]"
			},
			{
				"name":"105383568 eff; ubiquitin-conjugating enzyme E2 eff\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"105394208 LOC105394208; ubiquitin-conjugating enzyme E2-24 kDa isoform X1\tK20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]"
			},
			{
				"name":"105382837 Ube2g1; ubiquitin-conjugating enzyme E2G 1 isoform X1\tK10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]"
			},
			{
				"name":"105391696 Ubc7; ubiquitin conjugating enzyme 7\tK04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]"
			},
			{
				"name":"105386228 UbcE2H; ubiquitin conjugating enzyme E2H\tK10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]"
			},
			{
				"name":"105391638 LOC105391638; ubiquitin-conjugating enzyme E2 J1\tK10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]"
			},
			{
				"name":"119693130 LOC119693130; ubiquitin-conjugating enzyme E2 J2\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"105385355 Ubc4; ubiquitin conjugating enzyme 4\tK04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]"
			},
			{
				"name":"105394818 Ubc10; ubiquitin conjugating enzyme 10\tK04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]"
			},
			{
				"name":"105382572 Ubc13; ubiquitin conjugating enzyme E2\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
			},
			{
				"name":"105383164 LOC105383164; (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O\tK10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]"
			},
			{
				"name":"105382890 LOC105382890; ubiquitin-conjugating enzyme E2 Q2\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"105385877 LOC105385877; ubiquitin-conjugating enzyme E2Q-like protein 1\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"105382970 LOC105382970; ubiquitin-conjugating enzyme E2 R1\tK02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]"
			},
			{
				"name":"105381511 LOC105381511; ubiquitin-conjugating enzyme E2 T\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
			},
			{
				"name":"105396699 LOC105396699; ubiquitin-conjugating enzyme E2 W\tK10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]"
			}
			]
		},
		{
			"name":"UBL-conjugating enzymes",
			"children":[
			{
				"name":"105385585 lwr; ubiquitin conjugating enzyme lesswright\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"105382212 LOC105382212; NEDD8-conjugating enzyme UBE2F\tK10687 UBE2F; ubiquitin-conjugating enzyme E2 F [EC:2.3.2.34]"
			},
			{
				"name":"105386127 UbcE2M; NEDD8-conjugating enzyme UbcE2M\tK10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]"
			},
			{
				"name":"105386927 Atg3; autophagy-related protein 3\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
			},
			{
				"name":"125489270 Atg10; autophagy-related 10\tK17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10"
			},
			{
				"name":"105391101 Ufc1; ubiquitin-fold modifier conjugating enzyme 1\tK12165 UFC1; ufm1-conjugating enzyme 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin ligases (E3)",
		"children":[
		{
			"name":"HECT type E3",
			"children":[
			{
				"name":"105383691 LOC105383691; ubiquitin-protein ligase E3B\tK10588 UBE3B; ubiquitin-protein ligase E3 B [EC:2.3.2.26]"
			},
			{
				"name":"105397526 LOC105397526; ubiquitin-protein ligase E3C\tK10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]"
			},
			{
				"name":"105386622 Smurf; SMAD specific E3 ubiquitin protein ligase\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"105388335 Su(dx); suppressor of deltex\tK05633 WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]"
			},
			{
				"name":"105384037 Nedd4; E3 ubiquitin-protein ligase Nedd4\tK10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]"
			},
			{
				"name":"105398172 hyd; E3 ubiquitin-protein ligase hyd\tK10593 EDD1; E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]"
			},
			{
				"name":"105380725 LOC105380725; uncharacterized protein LOC105380725\tK22371 G2H3; G2\/M phase-specific E3 ubiquitin-protein ligase [EC:2.3.2.26]"
			},
			{
				"name":"105384485 Herc4; HECT and RLD domain containing E3 ubiquitin ligase 4\tK10615 HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]"
			},
			{
				"name":"105392491 Hecw; hecw ubiquitin protein ligase isoform X1\tK12168 HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]"
			},
			{
				"name":"HECT type E3 associated proteins",
				"children":[
				{
					"name":"105386689 Ndfip; nedd4 family interacting protein isoform X1\tK25839 NDFIP; NEDD4 family-interacting protein"
				}
				]
			}
			]
		},
		{
			"name":"U-box type E3",
			"children":[
			{
				"name":"105393015 Ube4A; ubiquitination factor E4A\tK10596 UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]"
			},
			{
				"name":"105390778 Ube4B; ubiquitination factor E4B\tK10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]"
			},
			{
				"name":"119691459 STUB1; STIP1 homology and U-box containing protein 1\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
			},
			{
				"name":"105394240 LOC105394240; RING-type E3 ubiquitin-protein ligase PPIL2\tK10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]"
			},
			{
				"name":"105387829 Prp19; pre-mRNA processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"Single Ring-finger type E3",
			"children":[
			{
				"name":"BRE1 proteins",
				"children":[
				{
					"name":"105390285 Bre1; E3 ubiquitin-protein ligase Bre1 isoform X1\tK10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"CBL proteins",
				"children":[
				{
					"name":"105391330 Cbl; E3 ubiquitin-protein ligase CBL isoform X2\tK04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"SINA (Seven in absentia) proteins",
				"children":[
				{
					"name":"105382923 LOC105382923; E3 ubiquitin-protein ligase SIAH1A\tK04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]"
				},
				{
					"name":"105387644 LOC105387644; uncharacterized protein LOC105387644 isoform X1\tK04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]"
				},
				{
					"name":"105398123 LOC105398123; E3 ubiquitin-protein ligase siah-1\tK04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Ligand of Numb proteins"
			},
			{
				"name":"March proteins",
				"children":[
				{
					"name":"105397805 LOC105397805; E3 ubiquitin-protein ligase MARCHF8 isoform X1\tK10656 MARCH1_8; E3 ubiquitin-protein ligase MARCH1\/8 [EC:2.3.2.27]"
				},
				{
					"name":"105380980 LOC105380980; uncharacterized protein LOC105380980 isoform X1\tK10657 MARCH2_3; E3 ubiquitin-protein ligase MARCH2\/3 [EC:2.3.2.27]"
				},
				{
					"name":"105391051 LOC105391051; uncharacterized protein LOC105391051 isoform X1\tK10657 MARCH2_3; E3 ubiquitin-protein ligase MARCH2\/3 [EC:2.3.2.27]"
				},
				{
					"name":"105392673 LOC105392673; E3 ubiquitin-protein ligase MARCHF5\tK10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]"
				},
				{
					"name":"105388430 LOC105388430; E3 ubiquitin-protein ligase MARCHF6\tK10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"MDM2\/MDM4 proteins",
				"children":[
				{
					"name":"105381544 LOC105381544; protein Mdm4\tK06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"NFX1 proteins",
				"children":[
				{
					"name":"105390857 LOC105390857; NF-X1-type zinc finger protein NFXL1\tK15683 NFXL1; NF-X1-type zinc finger protein NFXL1"
				}
				]
			},
			{
				"name":"Pellino proteins",
				"children":[
				{
					"name":"105383659 Pli; E3 ubiquitin-protein ligase pellino\tK11964 PELI; pellino [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Peripheral membrane proteins",
				"children":[
				{
					"name":"105393875 Pex10; peroxisomal biogenesis factor 10\tK13346 PEX10; peroxin-10 [EC:2.3.2.27]"
				},
				{
					"name":"105395161 Pex12; peroxisomal biogenesis factor 12\tK13345 PEX12; peroxin-12"
				},
				{
					"name":"105382726 Pex2; peroxisomal biogenesis factor 2\tK06664 PEX2; peroxin-2 [EC:2.3.2.27 2.3.2.36]"
				}
				]
			},
			{
				"name":"RBR proteins",
				"children":[
				{
					"name":"119693166 ari-1; E3 ubiquitin-protein ligase ariadne-1 isoform X1\tK11968 ARIH1; ariadne-1 [EC:2.3.2.31]"
				},
				{
					"name":"105389152 ari-2; E3 ubiquitin-protein ligase ari-2\tK11969 ARIH2; ariadne-2 [EC:2.3.2.31]"
				},
				{
					"name":"105383741 LOC105383741; uncharacterized protein LOC105383741\tK11975 RNF144; E3 ubiquitin-protein ligase RNF144 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"TRAF proteins",
				"children":[
				{
					"name":"105382485 LOC105382485; TNF receptor-associated factor 6\tK03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"TRIM\/RBCC proteins",
				"children":[
				{
					"name":"105381667 LOC105381667; tripartite motif-containing protein 3\tK11997 TRIM2_3; tripartite motif-containing protein 2\/3"
				},
				{
					"name":"105384515 brat; tripartite motif-containing protein brain tumor isoform X1\tK11997 TRIM2_3; tripartite motif-containing protein 2\/3"
				},
				{
					"name":"105384693 Trim9; E3 ubiquitin-protein ligase Trim9\tK10649 TRIM9_67; tripartite motif-containing protein 9\/67"
				},
				{
					"name":"105387205 LOC105387205; E3 ubiquitin-protein ligase TRIM45\tK12021 TRIM45; tripartite motif-containing protein 45"
				},
				{
					"name":"105391994 wech; tripartite motif containing 71 protein wech\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"UBR box proteins",
				"children":[
				{
					"name":"105386572 poe; E3 ubiquitin-protein ligase-like protein poe\tK10691 UBR4; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]"
				},
				{
					"name":"105393499 LOC105393499; putative E3 ubiquitin-protein ligase UBR7\tK11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"ATL proteins"
			},
			{
				"name":"Other single Ring-finger type E3",
				"children":[
				{
					"name":"105385525 Diap2; death-associated inhibitor of apoptosis 2\tK16060 BIRC2_3; baculoviral IAP repeat-containing protein 2\/3"
				},
				{
					"name":"105388385 LOC105388385; BRCA1-associated protein\tK10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]"
				},
				{
					"name":"105385130 LOC105385130; uncharacterized protein LOC105385130\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
				},
				{
					"name":"105381190 Cnot4; CCR4-NOT transcription complex subunit 4\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
				},
				{
					"name":"105381488 Fancl; E3 ubiquitin-protein ligase Fancl\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
				},
				{
					"name":"105397459 Kcmf1; potassium channel modulatory factor 1\tK22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]"
				},
				{
					"name":"105395629 LOC105395629; E3 ubiquitin-protein ligase LRSAM1\tK10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]"
				},
				{
					"name":"119693147 LOC119693147; RNA-binding protein MEX3A\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]"
				},
				{
					"name":"105384093 LOC105384093; E3 ubiquitin-protein ligase mind-bomb\tK10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]"
				},
				{
					"name":"105392164 Mul1; mitochondrial E3 ubiquitin protein ligase 1\tK15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]"
				},
				{
					"name":"105390859 dnr1; E3 ubiquitin-protein ligase defense repressor 1\tK10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]"
				},
				{
					"name":"105383624 neur; E3 ubiquitin-protein ligase neur\tK01931 NEUR; protein neuralized [EC:2.3.2.27]"
				},
				{
					"name":"105390710 Rchy1; ring finger and CHY zinc finger domain containing 1 isoform X1\tK10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"105398569 roq; RING finger and CCCH-type zinc finger domain-containing protein roquin isoform X1\tK15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein"
				},
				{
					"name":"105382059 LOC105382059; E3 ubiquitin-protein ligase COP1\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
				},
				{
					"name":"105395484 LOC105395484; E3 ubiquitin-protein ligase RFWD3\tK15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]"
				},
				{
					"name":"105380400 Sce; E3 ubiquitin-protein ligase Sce\tK10695 RNF1_2; E3 ubiquitin-protein ligase RNF1\/2 [EC:2.3.2.27]"
				},
				{
					"name":"105386366 LOC105386366; uncharacterized protein LOC105386366\tK22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]"
				},
				{
					"name":"105390920 LOC105390920; E3 ubiquitin-protein ligase RNF185\tK10666 RNF5_185; E3 ubiquitin-protein ligase RNF5\/185 [EC:2.3.2.27]"
				},
				{
					"name":"105395626 LOC105395626; uncharacterized protein LOC105395626\tK10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]"
				},
				{
					"name":"105386660 LOC105386660; E3 ubiquitin-protein ligase RNF10\tK26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]"
				},
				{
					"name":"105386770 gzl; godzilla E3 ubiquitin protein ligase\tK15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]"
				},
				{
					"name":"105383770 LOC105383770; E3 ubiquitin-protein ligase RNF25\tK10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]"
				},
				{
					"name":"105383026 elgi; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NRDP1 elgi\tK11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]"
				},
				{
					"name":"105385605 LOC105385605; E3 ubiquitin-protein ligase RNF115 isoform X1\tK11982 RNF115_126; E3 ubiquitin-protein ligase RNF115\/126 [EC:2.3.2.27]"
				},
				{
					"name":"105392099 LOC105392099; E3 ubiquitin ligase Rnf121\tK15698 RNF121_175; RING finger protein 121\/175"
				},
				{
					"name":"105380983 LOC105380983; E3 ubiquitin-protein ligase RNF123 isoform X1\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"105388168 Trc8; TRC8 ring finger protein\tK15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]"
				},
				{
					"name":"105386443 Rnf146; ring finger protein 146\tK15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]"
				},
				{
					"name":"105394031 Mrgn1; mahogunin ring finger 1\tK25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]"
				},
				{
					"name":"105389990 LOC105389990; E3 ubiquitin-protein ligase RNF181\tK22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]"
				},
				{
					"name":"105389527 LOC105389527; E3 ubiquitin-protein ligase RNFT2\tK28516 RNFT2; E3 ubiquitin-protein ligase RNFT2"
				},
				{
					"name":"105393407 LOC105393407; U4\/U6.U5 tri-snRNP-associated protein 1\tK11984 SART1; U4\/U6.U5 tri-snRNP-associated protein 1"
				},
				{
					"name":"105389249 POSH; SH3 domain containing ring finger posh isoform X1\tK12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"
				},
				{
					"name":"119691097 sip3; septin interacting protein 3\tK10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]"
				},
				{
					"name":"105392131 LOC105392131; E3 ubiquitin-protein ligase TM129\tK22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]"
				},
				{
					"name":"105398044 LOC105398044; E3 ubiquitin-protein ligase UHRF1\tK10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Atypical E3",
			"children":[
			{
				"name":"105390662 Nse1; SMC5-SMC6 complex component Non-SMC element 1\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
			},
			{
				"name":"105392331 Pits; protein interacting with Ttk69 and Sin3A\tK22383 IRF2BP; interferon regulatory factor 2-binding protein"
			}
			]
		},
		{
			"name":"UBL E3 ligases",
			"children":[
			{
				"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
			},
			{
				"name":"105390715 Su(var)2-10; E3 SUMO-protein ligase Su(var)2-10\tK04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]"
			},
			{
				"name":"105382099 LOC105382099; E3 SUMO-protein ligase NSE2\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
			},
			{
				"name":"105384725 LOC105384725; E3 ubiquitin-protein ligase RNF212B isoform X1\tK25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]"
			},
			{
				"name":"105386969 Ufl1; UFM1 specific ligase 1\tK22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]"
			},
			{
				"name":"105383665 SCCRO; defective in cullin neddylation 1 domain containing SCCRO\tK17822 DCUN1D1_2; DCN1-like protein 1\/2"
			},
			{
				"name":"105392442 SCCRO3; defective in cullin neddylation 1 domain containing SCCRO3\tK17823 DCUN1D3; DCN1-like protein 3"
			},
			{
				"name":"105392226 SCCRO4; DCN1-like protein SCCRO4\tK17824 DCUN1D4_5; DCN1-like protein 4\/5"
			}
			]
		},
		{
			"name":"Multi subunit type E3",
			"children":[
			{
				"name":"SCF complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"105384376 Cul1; cullin 1\tK03347 CUL1; cullin 1"
					}
					]
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"105397971 SkpA; S-phase kinase associated protein 1 SKP1-related A\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (F-box)",
					"children":[
					{
						"name":"105393673 slmb; beta-transducin repeat containing E3 ubiquitin protein ligase slmb\tK03362 FBXW1_11; F-box and WD-40 domain protein 1\/11"
					},
					{
						"name":"105390568 LOC105390568; F-box\/WD repeat-containing protein 4\tK10262 FBXW4; F-box and WD-40 domain protein 4"
					},
					{
						"name":"105393514 ago; F-box and WD-40 domain protein 7\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"105391422 LOC105391422; S-phase kinase-associated protein 2\tK03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)"
					},
					{
						"name":"105383862 LOC105383862; uncharacterized protein LOC105383862\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"105390394 LOC105390394; uncharacterized protein LOC105390394\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"105397172 LOC105397172; uncharacterized protein LOC105397172\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"105380332 Fbxl4; F box and leucine-rich-repeat gene 4\tK10270 FBXL4; F-box and leucine-rich repeat protein 4"
					},
					{
						"name":"105382605 Fbxl7; F-box and leucine-rich repeat protein 7\tK10273 FBXL7; F-box and leucine-rich repeat protein 7"
					},
					{
						"name":"105385252 LOC105385252; uncharacterized protein LOC105385252\tK10275 FBXL9; F-box and leucine-rich repeat protein 9"
					},
					{
						"name":"105381154 LOC105381154; jmjC domain-containing histone demethylation protein 1 isoform X1\tK10276 FBXL10_11; F-box and leucine-rich repeat protein 10\/11 [EC:1.14.11.27]"
					},
					{
						"name":"105386007 Ppa; F-box and leucine rich repeat protein partner of paired\tK10280 FBXL14; F-box and leucine-rich repeat protein 14"
					},
					{
						"name":"105384942 jet; F-box and leucine rich repeat protein jetlag\tK10281 FBXL15; F-box and leucine-rich repeat protein 15"
					},
					{
						"name":"105386455 LOC105386455; F-box\/LRR-repeat protein 16\tK10282 FBXL16; F-box and leucine-rich repeat protein 16"
					},
					{
						"name":"105389161 LOC105389161; uncharacterized protein LOC105389161\tK10292 FBXO5; F-box protein 5"
					},
					{
						"name":"105384562 LOC105384562; F-box only protein 9 isoform X1\tK10295 FBXO9; F-box protein 9"
					},
					{
						"name":"105380825 FBXO11; F-box protein 11\tK10297 FBXO11; F-box protein 11"
					},
					{
						"name":"105385707 smash; smallish\tK06084 LMO7; F-box protein 20"
					},
					{
						"name":"105385772 LOC105385772; F-box only protein 25\tK10305 FBXO25_32; F-box protein 25\/32"
					},
					{
						"name":"105390173 pall; F-box protein pallbearer isoform X1\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"105391778 dmpd; F-box protein dampened isoform X1\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"125488485 LOC125488485; uncharacterized protein LOC125488485\tK10310 FBXO33; F-box protein 33"
					},
					{
						"name":"105395674 Fbxo42; F-box protein 42\tK10317 FBXO42; F-box protein 42"
					},
					{
						"name":"105386154 Fsn; F-box synaptic protein\tK10319 FBXO45; F-box protein 45"
					}
					]
				}
				]
			},
			{
				"name":"Cul2 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"105388639 EloC; transcription elongation factor elongin C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"105383959 EloB; transcription elongation factor elongin B\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"105385408 LOC105385408; leucine-rich repeat protein 1\tK10348 LRR1; LRR-repeat protein 1"
					},
					{
						"name":"105398393 LOC105398393; protein fem-1 homolog CG6966\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"119692185 m-cup; ankyrin repeat protein mann-cup\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"105391976 Fem-1; protein fem-1 homolog B\tK10349 FEM1B; protein fem-1 homolog B"
					},
					{
						"name":"105394978 Pat1; LOW QUALITY PROTEIN: protein interacting with APP tail-1\tK25806 APPBP2; amyloid protein-binding protein 2"
					},
					{
						"name":"105387385 LOC105387385; kelch domain-containing protein 3\tK25808 KLHDC3; kelch domain-containing protein 3"
					},
					{
						"name":"105398200 LOC105398200; protein zer-1 homolog\tK10350 ZYG11; Zyg-11 protein"
					},
					{
						"name":"105384484 LOC105384484; zinc finger SWIM domain-containing protein 8 homolog\tK25207 ZSWIM8; zinc finger SWIM domain-containing protein 8"
					}
					]
				}
				]
			},
			{
				"name":"Cul3 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"105386146 Cul3; cullin 3 isoform X1\tK03869 CUL3; cullin 3"
					}
					]
				},
				{
					"name":"Adoptor and target recognizing subunit (BTB)",
					"children":[
					{
						"name":"105381989 LOC105381989; kelch-like protein 5 isoform X1\tK10442 KLHL1_4_5; kelch-like protein 1\/4\/5"
					},
					{
						"name":"119691977 LOC119691977; kelch-like protein 32\tK10442 KLHL1_4_5; kelch-like protein 1\/4\/5"
					},
					{
						"name":"105387757 kel; kelch protein\tK10443 KLHL2_3; kelch-like protein 2\/3"
					},
					{
						"name":"105392650 LOC105392650; kelch-like protein 10\tK10448 KLHL10; kelch-like protein 10"
					},
					{
						"name":"105397268 klhl10; kelch-like protein 10 isoform X1\tK10448 KLHL10; kelch-like protein 10"
					},
					{
						"name":"105383020 Keap1; kelch like ECH associated protein 1\tK10456 KLHL19; kelch-like protein 19"
					},
					{
						"name":"105395816 dbo; kelch-like protein diablo isoform X3\tK10457 KLHL20; kelch-like protein 20"
					},
					{
						"name":"105386488 LOC105386488; actin-binding protein IPP\tK13956 IPP; actin-binding protein IPP"
					},
					{
						"name":"105387331 LOC105387331; BTB\/POZ domain-containing protein 6-A\tK10477 BTBD1_2; BTB\/POZ domain-containing protein 1\/2"
					},
					{
						"name":"119693228 LOC119693228; BTB\/POZ domain-containing protein 2\tK10477 BTBD1_2; BTB\/POZ domain-containing protein 1\/2"
					},
					{
						"name":"105380387 lute; BTB\/POZ domain containing protein 3 lute\tK10478 BTBD3_6; BTB\/POZ domain-containing protein 3\/6"
					},
					{
						"name":"105382947 BTBD9; BTB (POZ) domain containing 9\tK10481 BTBD9; BTB\/POZ domain-containing protein 9"
					},
					{
						"name":"105379964 mri; BTB\/POZ domain-containing protein mrityu\tK10482 BTBD10; BTB\/POZ domain-containing protein 10"
					},
					{
						"name":"105392852 RhoBTB; LOW QUALITY PROTEIN: rho-related BTB domain containing\tK07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1\/2"
					},
					{
						"name":"105395478 LOC105395478; BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3\tK15074 BACURD; BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein"
					},
					{
						"name":"105380541 twz; BTB\/POZ domain-containing protein twz\tK21754 KCTD1_15; BTB\/POZ domain-containing protein KCTD1\/15"
					},
					{
						"name":"119691556 inc; BTB\/POZ domain-containing protein inc\tK21914 KCTD2_5_17; BTB\/POZ domain-containing protein KCTD2\/5\/17"
					},
					{
						"name":"105380798 LOC105380798; BTB\/POZ domain-containing protein KCTD3\tK21915 KCTD3; BTB\/POZ domain-containing protein KCTD3"
					},
					{
						"name":"105384752 Ktl; BTB\/POZ domain-containing protein Ktl\tK21918 KCTD8_12_16; BTB\/POZ domain-containing protein KCTD8\/12\/16"
					},
					{
						"name":"105387033 LOC105387033; BTB\/POZ domain-containing protein KCTD9\tK21919 KCTD9; BTB\/POZ domain-containing protein KCTD9"
					},
					{
						"name":"105380341 LOC105380341; uncharacterized protein LOC105380341 isoform X1\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"105387018 LOC105387018; speckle-type POZ protein isoform X1\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"105389648 rdx; BTB\/POZ and MATH domain-containing protein rdx isoform X1\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"105392339 LOC105392339; speckle-type POZ protein-like\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"105398641 LOC105398641; TD and POZ domain-containing protein 1\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"105394213 LOC105394213; leucine-zipper-like transcriptional regulator 1\tK23330 LZTR1; leucine-zipper-like transcriptional regulator 1"
					}
					]
				}
				]
			},
			{
				"name":"Cul4 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"105390222 Cul4; cullin 4\tK10609 CUL4; cullin 4"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"105392169 pic; DNA damage-binding protein pic\tK10610 DDB1; DNA damage-binding protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (DCAF)",
					"children":[
					{
						"name":"119693114 abo; de-etiolated protein 1 abo\tK10571 DET1; de-etiolated-1"
					},
					{
						"name":"105382059 LOC105382059; E3 ubiquitin-protein ligase COP1\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
					},
					{
						"name":"105387951 LOC105387951; DET1- and DDB1-associated protein 1\tK11792 DDA1; DET1- and DDB1-associated protein 1"
					},
					{
						"name":"105395588 LOC105395588; protein cereblon\tK11793 CRBN; cereblon"
					},
					{
						"name":"105391949 mahj; lisH and WD40 domain-containing protein mahjong\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]"
					},
					{
						"name":"105380802 LOC105380802; uncharacterized protein LOC105380802\tK11800 DCAF5; DDB1- and CUL4-associated factor 5"
					},
					{
						"name":"105391088 wap; DDB1 and CUL4 associated factor wap\tK11805 DCAF7; DDB1- and CUL4-associated factor 7"
					},
					{
						"name":"105388940 adp; WD and tetratricopeptide repeats 1\tK11807 WDTC1; WD and tetratricopeptide repeats protein 1"
					},
					{
						"name":"105391635 LOC105391635; DDB1- and CUL4-associated factor 10 homolog\tK11802 DCAF10; DDB1- and CUL4-associated factor 10"
					},
					{
						"name":"105381005 DCAF12; DDB1 and CUL4 associated factor 12-like protein\tK11803 DCAF12; DDB1- and CUL4-associated factor 12"
					},
					{
						"name":"105387384 LOC105387384; DDB1- and CUL4-associated factor 13\tK11806 DCAF13; DDB1- and CUL4-associated factor 13"
					},
					{
						"name":"105389836 LOC105389836; uncharacterized protein LOC105389836\tK11791 DCAF15; DDB1- and CUL4-associated factor 15"
					},
					{
						"name":"105393411 LOC105393411; WD repeat-containing protein 26\tK22382 WDR26; WD repeat-containing protein 26"
					},
					{
						"name":"105389796 LOC105389796; gastrulation defective protein 1 homolog\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			},
			{
				"name":"Cul5 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105390694 Roc2; regulator of cullins 2\tK10611 RBX2; RING-box protein 2"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"105381980 Cul5; cullin 5\tK10612 CUL5; cullin 5"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"105388639 EloC; transcription elongation factor elongin C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"105383959 EloB; transcription elongation factor elongin B\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"105385539 SOCS2-12; SOCS2-12 protein isoform X1\tK04695 SOCS2; suppressor of cytokine signaling 2"
					},
					{
						"name":"105396212 SOCS5; LOW QUALITY PROTEIN: suppressor of cytokine signaling 5\tK04698 SOCS5; suppressor of cytokine signaling 5"
					},
					{
						"name":"125491257 LOC125491257; uncharacterized protein LOC125491257 isoform X1\tK10325 ASB3; ankyrin repeat and SOCS box protein 3"
					},
					{
						"name":"105383488 stops; SOCS domain-containing protein stops\tK10339 ASB17; ankyrin repeat and SOCS box protein 17"
					},
					{
						"name":"105380100 gus; splA\/ryanodine receptor domain and SOCS box containing gustavus isoform X1\tK10343 SPSB1_4; SPRY domain-containing SOCS box protein 1\/4"
					},
					{
						"name":"105394180 LOC105394180; SPRY domain-containing SOCS box protein 3 isoform X1\tK10345 SPSB3; SPRY domain-containing SOCS box protein 3"
					},
					{
						"name":"105381719 Rab40; RAS oncogene family member Rab40\tK07928 RAB40; Ras-related protein Rab-40"
					}
					]
				}
				]
			},
			{
				"name":"Cul7 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"105397971 SkpA; S-phase kinase associated protein 1 SKP1-related A\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul8 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein"
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul9 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"105397966 Roc1a; regulator of cullins 1a\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				}
				]
			},
			{
				"name":"APC\/C",
				"children":[
				{
					"name":"Ring finger protein"
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"105392969 morula; anaphase promoting complex subunit morula\tK03349 APC2; anaphase-promoting complex subunit 2"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"105383943 fzy; cell division cycle 20 protein fzy\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"105380719 fzr; fizzy and cell division cycle 20 related\tK03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex"
					}
					]
				},
				{
					"name":"Other subunits",
					"children":[
					{
						"name":"105393793 Cdc27; cell division cycle protein 27\tK03350 APC3; anaphase-promoting complex subunit 3"
					},
					{
						"name":"105385646 APC4; anaphase-promoting complex subunit 4\tK03351 APC4; anaphase-promoting complex subunit 4"
					},
					{
						"name":"105384107 Cdc16; cell division cycle protein 16\tK03353 APC6; anaphase-promoting complex subunit 6"
					},
					{
						"name":"105393759 LOC105393759; uncharacterized protein LOC105393759\tK03355 APC8; anaphase-promoting complex subunit 8"
					},
					{
						"name":"105385238 APC10; anaphase-promoting complex subunit 10\tK03357 APC10; anaphase-promoting complex subunit 10"
					},
					{
						"name":"119690385 LOC119690385; anaphase-promoting complex subunit 13\tK12456 APC13; anaphase-promoting complex subunit 13"
					},
					{
						"name":"105386137 LOC105386137; uncharacterized protein LOC105386137\tK25228 APC15; anaphase-promoting complex subunit 15"
					}
					]
				}
				]
			},
			{
				"name":"BRCC complex",
				"children":[
				{
					"name":"105385130 LOC105385130; uncharacterized protein LOC105385130\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
				},
				{
					"name":"105395681 LOC105395681; lys-63-specific deubiquitinase BRCC36\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
				},
				{
					"name":"105397228 LOC105397228; BRCA1-associated RING domain protein 1\tK10683 BARD1; BRCA1-associated RING domain protein 1"
				},
				{
					"name":"105397206 LOC105397206; BRISC and BRCA1-A complex member 2\tK12173 BRE; BRCA1-A complex subunit BRE"
				},
				{
					"name":"105392937 spn-A; RAD51 recombinase homolog spn-A\tK04482 RAD51; DNA repair protein RAD51"
				}
				]
			},
			{
				"name":"KPC complex",
				"children":[
				{
					"name":"105380983 LOC105380983; E3 ubiquitin-protein ligase RNF123 isoform X1\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"LUBAC complex"
			},
			{
				"name":"CTLH complex",
				"children":[
				{
					"name":"105386653 Sou; required for meiotic nuclear division 5 protein souji\tK23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]"
				},
				{
					"name":"105390300 RanBPM; ran-binding protein M isoform X1\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				},
				{
					"name":"105392657 LOC105392657; armadillo repeat-containing protein 8\tK23336 ARMC8; armadillo repeat-containing protein 8"
				},
				{
					"name":"105388862 Kaz; E3 ubiquitin-protein transferase Katazuke\tK18624 MAEA; macrophage erythroblast attacher"
				},
				{
					"name":"119691488 LOC119691488; glucose-induced degradation protein 4 homolog\tK23335 GID4; glucose-induced degradation protein 4"
				},
				{
					"name":"105390265 Hou; GID complex subunit 8 homolog protein Houki isoform X1\tK23338 GID8; glucose-induced degradation protein 8"
				},
				{
					"name":"105386288 Yippee; yippee zinc finger protein\tK23339 YPEL5; protein yippee-like 5"
				},
				{
					"name":"105393411 LOC105393411; WD repeat-containing protein 26\tK22382 WDR26; WD repeat-containing protein 26"
				}
				]
			},
			{
				"name":"ERAD complex",
				"children":[
				{
					"name":"105397381 LOC105397381; uncharacterized protein LOC105397381\tK23340 TMUB; transmembrane and ubiquitin-like domain-containing protein"
				},
				{
					"name":"105390788 LOC105390788; erlin-2\tK23341 ERLIN; erlin"
				}
				]
			},
			{
				"name":"LMBR1L-GP78-UBAC2 complex",
				"children":[
				{
					"name":"105382873 lili; LMBR1-like protein lilipod\tK25215 LMBR1L; protein LMBR1L"
				}
				]
			},
			{
				"name":"STUB1-CHIC2  complex",
				"children":[
				{
					"name":"119691459 STUB1; STIP1 homology and U-box containing protein 1\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"105390566 LOC105390566; cysteine-rich hydrophobic domain-containing protein 2\tK28185 CHIC2; cysteine-rich hydrophobic domain-containing protein 2"
				}
				]
			},
			{
				"name":"SLX5-SLX8 complex"
			},
			{
				"name":"Multi subunit type E3 associated proteins",
				"children":[
				{
					"name":"105391299 Cand1; cullin-associated and neddylation-dissociated 1\tK17263 CAND1; cullin-associated NEDD8-dissociated protein 1"
				},
				{
					"name":"105388323 LOC105388323; COMM domain-containing protein 2\tK22558 COMMD2; COMM domain containing 2"
				},
				{
					"name":"105381496 COMMD4; COMM domain containing 4\tK22560 COMMD4; COMM domain containing 4"
				},
				{
					"name":"105385014 LOC105385014; COMM domain-containing protein 5\tK22561 COMMD5; COMM domain containing 5"
				},
				{
					"name":"105385650 LOC105385650; coiled-coil domain-containing protein 22 homolog\tK23343 CCDC22; coiled-coil domain-containing protein 22"
				},
				{
					"name":"105391322 Ddrgk1; DDRGK domain containing 1\tK23344 DDRGK1; DDRGK domain-containing protein 1"
				},
				{
					"name":"105384709 LOC105384709; parkin coregulated gene protein homolog\tK26163 PACRG; parkin coregulated gene protein"
				},
				{
					"name":"105390067 Dlish; dachs ligand with SH3s\tK26546 Dlish; SH3 domain-containing protein Dlish"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Deubiquitinating enzyme (DUB)",
		"children":[
		{
			"name":"Ubiquitin-specific proteases (UBPs)",
			"children":[
			{
				"name":"UCH",
				"children":[
				{
					"name":"105397533 calypso; ubiquitin carboxyl-terminal hydrolase calypso\tK08588 BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]"
				},
				{
					"name":"105385549 Uch; ubiquitin carboxyl-terminal hydrolase\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
				},
				{
					"name":"105386055 Uch-L5; ubiquitin carboxy-terminal hydrolase L5 isoform X1\tK05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"UBP\/USP",
				"children":[
				{
					"name":"105396357 Usp1; ubiquitin specific protease 1 isoform X1\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
				},
				{
					"name":"105395608 LOC105395608; uncharacterized protein LOC105395608\tK11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]"
				},
				{
					"name":"105392779 LOC105392779; ubiquitin carboxyl-terminal hydrolase 3\tK11986 USP3; ubiquitin carboxyl-terminal hydrolase 3 [EC:3.4.19.12]"
				},
				{
					"name":"105383754 Usp5; ubiquitin specific protease 5\tK11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5\/13 [EC:3.4.19.12]"
				},
				{
					"name":"105394659 Usp7; ubiquitin-specific protease 7 isoform X1\tK11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]"
				},
				{
					"name":"105394667 LOC105394667; ubiquitin carboxyl-terminal hydrolase 7\tK11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]"
				},
				{
					"name":"105390491 faf; ubiquitin carboxyl-terminal hydrolase-like faf\tK11840 USP9_24; ubiquitin carboxyl-terminal hydrolase 9\/24 [EC:3.4.19.12]"
				},
				{
					"name":"105385222 Usp12-46; ubiquitin-specific protease 12\/46\tK11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12\/46 [EC:3.4.19.12]"
				},
				{
					"name":"105391984 Usp14; ubiquitin specific protease 14\tK11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]"
				},
				{
					"name":"105381081 Usp16-45; ubiquitin specific protease 16\/45 isoform X1\tK11844 USP16_45; ubiquitin carboxyl-terminal hydrolase 16\/45 [EC:3.4.19.12]"
				},
				{
					"name":"105384676 Usp20-33; ubiquitin specific protease 20\/33\tK11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20\/33 [EC:3.4.19.12]"
				},
				{
					"name":"105386625 not; ubiquitin carboxyl-terminal hydrolase nonstop\tK11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22\/27\/51 [EC:3.4.19.12]"
				},
				{
					"name":"105393339 Usp30; ubiquitin specific protease 30\tK11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]"
				},
				{
					"name":"105380450 puf; ubiquitinyl hydrolase 1 puf\tK11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]"
				},
				{
					"name":"105388148 DUBAI; deubiquitinating apoptotic inhibitor isoform X1\tK11854 USP35_38; ubiquitin carboxyl-terminal hydrolase 35\/38 [EC:3.4.19.12]"
				},
				{
					"name":"105389135 ec; ubiquitin specific peptidase echinus\tK27920 USP54; ubiquitin carboxyl-terminal hydrolase 54 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"OTU",
				"children":[
				{
					"name":"105393498 LOC105393498; ubiquitin thioesterase otubain-like\tK09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]"
				},
				{
					"name":"105391805 LOC105391805; deubiquitinase OTUD6B\tK18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]"
				},
				{
					"name":"105382790 LOC105382790; OTU domain-containing protein 7B\tK11860 OTUD7A_B; OTU domain-containing protein 7 [EC:3.4.19.12]"
				},
				{
					"name":"105395474 trbd; ubiquitin thioesterase trabid\tK11862 ZRANB1; ubiquitin thioesterase ZRANB1 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MJD",
				"children":[
				{
					"name":"105391029 Josd; josephin domain containing\tK15235 JOSD; josephin [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MINDY",
				"children":[
				{
					"name":"105383422 LOC105383422; inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				},
				{
					"name":"105387338 LOC105387338; ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"JAMM",
				"children":[
				{
					"name":"105395681 LOC105395681; lys-63-specific deubiquitinase BRCC36\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
				},
				{
					"name":"105380298 LOC105380298; uncharacterized protein LOC105380298\tK24173 MPND; MPN domain-containing protein"
				},
				{
					"name":"105380111 Rpn11; regulatory particle non-ATPase 11\tK03030 PSMD14; 26S proteasome regulatory subunit N11"
				},
				{
					"name":"105389137 LOC105389137; STAM-binding protein-like A\tK11866 STAMBP; STAM-binding protein [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"PPPDE",
				"children":[
				{
					"name":"105398068 LOC105398068; deubiquitinase DESI2 isoform X1\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"ZUFSP"
			},
			{
				"name":"BRISC complex",
				"children":[
				{
					"name":"105397302 LOC105397302; BRISC and BRCA1-A complex member 1\tK20776 BABAM; BRISC and BRCA1-A complex member 1"
				},
				{
					"name":"105395681 LOC105395681; lys-63-specific deubiquitinase BRCC36\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
				},
				{
					"name":"105397206 LOC105397206; BRISC and BRCA1-A complex member 2\tK12173 BRE; BRCA1-A complex subunit BRE"
				}
				]
			}
			]
		},
		{
			"name":"UBL-specific proteases (ULPs)",
			"children":[
			{
				"name":"105384781 LOC105384781; uncharacterized protein LOC105384781 isoform X1\tK08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]"
			},
			{
				"name":"105380154 LOC105380154; sentrin-specific protease 8\tK08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]"
			},
			{
				"name":"105385549 Uch; ubiquitin carboxyl-terminal hydrolase\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
			},
			{
				"name":"105390281 LOC105390281; uncharacterized protein LOC105390281\tK22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]"
			},
			{
				"name":"COP9 signalosome (CSN) complex",
				"children":[
				{
					"name":"105393487 CSN1b; COP9 signalosome subunit 1b\tK12175 GPS1; COP9 signalosome complex subunit 1"
				},
				{
					"name":"105382586 alien; COP9 signalosome complex subunit 2 alien\tK12176 COPS2; COP9 signalosome complex subunit 2"
				},
				{
					"name":"105392520 CSN3; COP9 signalosome subunit 3\tK12177 COPS3; COP9 signalosome complex subunit 3"
				},
				{
					"name":"125488473 CSN4; COP9 signalosome subunit 4\tK12178 COPS4; COP9 signalosome complex subunit 4"
				},
				{
					"name":"105394292 CSN5; COP9 signalosome subunit 5\tK09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]"
				},
				{
					"name":"105382458 CSN6; COP9 signalosome subunit 6\tK12179 COPS6; COP9 signalosome complex subunit 6"
				},
				{
					"name":"105381331 CSN7; COP9 signalosome subunit 7\tK12180 COPS7; COP9 signalosome complex subunit 7"
				},
				{
					"name":"105380295 CSN8; COP9 signalosome subunit 8\tK12181 COPS8; COP9 signalosome complex subunit 8"
				},
				{
					"name":"145931740 LOC145931740; COP9 signalosome complex subunit 9\tK28062 COPS9; COP9 signalosome complex subunit 9"
				}
				]
			}
			]
		}
		]
	}
	]
}