{
	"name":"pym02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"AK972_6038 Phosphate regulon sensor protein PhoR (SphS)\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"AK972_6039 Phosphate regulon transcriptional regulatory protein PhoB (SphR)\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)",
			"children":[
			{
				"name":"AK972_1329 Sensor protein PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1328 Transcriptional regulatory protein PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
			}
			]
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"AK972_5688 Osmolarity sensory histidine kinase EnvZ\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"AK972_5689 Two-component system response regulator OmpR\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA",
			"children":[
			{
				"name":"AK972_1325 Sensor protein\tK07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1324 Transcriptional regulatory protein RstA\tK07661 rstA; two-component system, OmpR family, response regulator RstA"
			}
			]
		},
		{
			"name":"CpxA-CpxR (envelope stress response)",
			"children":[
			{
				"name":"AK972_1152 DNA-binding response regulator\tK07662 cpxR; two-component system, OmpR family, response regulator CpxR"
			}
			]
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)",
			"children":[
			{
				"name":"AK972_0293 Two-component response regulator CreC\tK07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]"
			},
			{
				"name":"AK972_0292 Two-component response regulator CreB\tK07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB"
			}
			]
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)",
			"children":[
			{
				"name":"AK972_0813 Heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_3837 Heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_4220 Osmosensitive K+ channel histidine kinase KdpD\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_5087 Heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_0812 DNA-binding heavy metal response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"AK972_3836 DNA-binding heavy metal response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"AK972_4219 Copper-sensing two-component system response regulator CusR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"AK972_5086 DNA-binding heavy metal response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"AK972_5091 DNA-binding heavy metal response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"AK972_5746 DNA-binding heavy metal response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			}
			]
		},
		{
			"name":"QseC-QseB (quorum sensing)",
			"children":[
			{
				"name":"AK972_1704 Sensor histidine kinase\tK07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]"
			},
			{
				"name":"AK972_4876 Sensory histidine kinase QseC\tK07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1703 Two-component system response regulator QseB\tK07666 qseB; two-component system, OmpR family, response regulator QseB"
			},
			{
				"name":"AK972_4877 Two-component system response regulator QseB\tK07666 qseB; two-component system, OmpR family, response regulator QseB"
			}
			]
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"AK972_1654 Osmosensitive K+ channel histidine kinase KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"AK972_4145 Osmosensitive K+ channel histidine kinase KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1653 sensor histidine kinase\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			},
			{
				"name":"AK972_4144 sensor histidine kinase\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)",
			"children":[
			{
				"name":"AK972_4528 Tricarboxylate transport sensor protein TctE\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"AK972_4529 Tricarboxylate transport transcriptional regulator TctD\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			}
			]
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)",
			"children":[
			{
				"name":"AK972_2784 Sensory histidine kinase in two-component regulatory system with RstA\tK18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_2783 Transcriptional regulatory protein RstA\tK18073 parR; two-component system, OmpR family, response regulator ParR"
			}
			]
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)",
			"children":[
			{
				"name":"AK972_1348 Two-component sensor histidine kinase PfeS, enterobactin\tK19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1347 Two-component response regulator PfeR, enterobactin\tK19610 pfeR; two-component system, OmpR family, response regulator PfeR"
			}
			]
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"AK972_2507 Sensory histidine kinase QseC\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"AK972_3849 hypothetical protein\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1062 DNA-binding response regulator GltR, controls specific porins for the entry of glucose\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_1612 DNA-binding response regulator GltR, controls specific porins for the entry of glucose\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_2039 Transcriptional regulatory protein ompR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_2506 Transcriptional regulatory protein RstA\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_3567 DNA-binding response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_3671 Two-component system response regulator QseB\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_3848 Two-component system response regulator QseB\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_4666 Phosphate regulon transcriptional regulatory protein PhoB (SphR)\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"AK972_4897 DNA-binding response regulator GltR, controls specific porins for the entry of glucose\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)",
			"children":[
			{
				"name":"AK972_3960 sensor histidine kinase\/response regulator\tK07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]"
			},
			{
				"name":"AK972_3962 Signal transduction histidine kinase\tK07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]"
			},
			{
				"name":"AK972_0869 two component transcriptional regulator, LuxR family\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			},
			{
				"name":"AK972_2112 Two-component response regulator\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			},
			{
				"name":"AK972_3963 two component transcriptional regulator, LuxR family\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			},
			{
				"name":"AK972_4791 DNA-binding response regulator, LuxR family\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			}
			]
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)",
			"children":[
			{
				"name":"AK972_1346 BarA sensory histidine kinase\tK07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]"
			},
			{
				"name":"AK972_2107 BarA-associated response regulator UvrY\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			}
			]
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)",
			"children":[
			{
				"name":"AK972_2885 Hybrid sensory histidine kinase in two-component regulatory system with EvgA\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_2915 Hybrid sensory histidine kinase in two-component regulatory system with EvgA\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_3493 Hybrid sensory histidine kinase in two-component regulatory system with EvgA\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_4084 Hybrid sensory histidine kinase in two-component regulatory system with EvgA\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_4793 Signal transduction histidine kinase\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_0962 DNA-binding response regulator, LuxR family\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
			},
			{
				"name":"AK972_2886 DNA-binding response regulator, LuxR family\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
			},
			{
				"name":"AK972_2916 DNA-binding response regulator, LuxR family\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
			},
			{
				"name":"AK972_3494 DNA-binding response regulator, LuxR family\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
			},
			{
				"name":"AK972_4083 DNA-binding response regulator, LuxR family\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
			}
			]
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)",
			"children":[
			{
				"name":"AK972_5273 Sensory box histidine kinase\tK27076 pprA; two-component system, NarL family, sensor histidine kinase PprA [EC:2.7.13.3]"
			},
			{
				"name":"AK972_5270 DNA-binding response regulator, LuxR family\tK27077 pprB; two-component system, NarL family, response regulator PprB"
			}
			]
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)",
			"children":[
			{
				"name":"AK972_6142 Autolysis response regulater LytR\tK08083 algR; two-component system, LytTR family, response regulator AlgR"
			}
			]
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"AK972_5575 Nitrogen regulation protein NtrB\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"AK972_5576 Nitrogen regulation protein NR(I)\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)",
			"children":[
			{
				"name":"AK972_5132 Two-component sensor CbrB: intrcellular carbon:nitrogen balance\tK07713 zraR; two-component system, NtrC family, response regulator HydG"
			}
			]
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"AK972_1071 C4-dicarboxylate transport sensor protein\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"AK972_5662 Signal transduction histidine kinase regulating C4-dicarboxylate transport system\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1070 Nitrogen regulation protein NR(I)\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			},
			{
				"name":"AK972_5663 C4-dicarboxylate transport transcriptional regulatory protein\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			}
			]
		},
		{
			"name":"KinB-AlgB (alginate production)",
			"children":[
			{
				"name":"AK972_5844 Sensory box histidine kinase\tK11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]"
			},
			{
				"name":"AK972_5843 Alginate biosynthesis transcriptional regulatory protein algB\tK11384 algB; two-component system, NtrC family, response regulator AlgB"
			}
			]
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"AK972_0920 Signal transduction histidine kinase\tK02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"AK972_1503 Signal transduction histidine kinase CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1501 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"AK972_1504 Chemotaxis response regulator protein-glutamate methylesterase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"AK972_2807 Protein-glutamate methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"AK972_0804 Chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			},
			{
				"name":"AK972_1315 Chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			},
			{
				"name":"AK972_1684 Chemotaxis protein CheV\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)",
			"children":[
			{
				"name":"AK972_0179 Signal transduction histidine kinase CheA\tK06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase\/response regulator)"
			},
			{
				"name":"AK972_0175 twitching motility protein PilG\tK02657 pilG; twitching motility two-component system response regulator PilG"
			},
			{
				"name":"AK972_0176 twitching motility protein PilH\tK02658 pilH; twitching motility two-component system response regulator PilH"
			}
			]
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)",
			"children":[
			{
				"name":"AK972_4764 Sensor histidine kinase\/response regulator\tK13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE"
			},
			{
				"name":"AK972_4762 diguanylate cyclase (GGDEF domain) with PAS\/PAC sensor\tK11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]"
			},
			{
				"name":"AK972_4763 Chemotaxis response regulator protein-glutamate methylesterase CheB\tK13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]"
			}
			]
		},
		{
			"name":"Cph1-Rcp1 (light response)",
			"children":[
			{
				"name":"AK972_1779 Phytochrome, two-component sensor histidine kinase\tK11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]"
			},
			{
				"name":"AK972_4895 Phytochrome, two-component sensor histidine kinase\tK11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)",
			"children":[
			{
				"name":"AK972_2931 Signal transduction response regulator\tK11443 divK; two-component system, cell cycle response regulator DivK"
			}
			]
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)",
			"children":[
			{
				"name":"AK972_2809 Response regulator\tK13589 cpdR; two-component system, cell cycle response regulator CpdR"
			}
			]
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)",
			"children":[
			{
				"name":"AK972_1476 Flagellar sensor histidine kinase FleS\tK10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1477 Flagellar regulatory protein FleQ\tK10943 flrC; two-component system, response regulator FlrC"
			}
			]
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)",
			"children":[
			{
				"name":"AK972_0939 Signal transduction histidine kinase regulating C4-dicarboxylate transport system\tK17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_0938 Two component, Sigma-54 Specific, central transcriptional regulator of acidic amino acid uptake\tK17061 aauR; two-component system, response regulator AauR"
			}
			]
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)",
			"children":[
			{
				"name":"AK972_0680 Sensor histidine kinase PrrB (RegB)\tK15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]"
			},
			{
				"name":"AK972_0681 Dna binding response regulator PrrA (RegA)\tK15012 regA; two-component system, response regulator RegA"
			}
			]
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)",
			"children":[
			{
				"name":"AK972_4087 sensor histidine kinase\/response regulator\tK20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1598 Sensor histidine kinase\/response regulator\tK20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]"
			},
			{
				"name":"AK972_1486 Hpt domain protein\tK20976 hptB; histidine phosphotransfer protein HptB"
			},
			{
				"name":"AK972_1485 Serine phosphatase RsbU, regulator of sigma subunit\tK20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator"
			}
			]
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT",
			"children":[
			{
				"name":"AK972_4311 Nitrate ABC transporter, nitrate-binding protein\tK22067 nasS; two-component system, oxyanion-binding sensor"
			},
			{
				"name":"AK972_4312 Response regulator NasT\tK07183 nasT; two-component system, response regulator \/ RNA-binding antiterminator"
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"AK972_0530 Sensor histidine kinase\tK20971 ladS; two-component system, sensor histidine kinase LadS"
			},
			{
				"name":"AK972_5300 Sensor histidine kinase\/response regulator\tK20972 retS; two-component system, sensor histidine kinase RetS"
			}
			]
		}
		]
	}
	]
}