{
	"name":"pyo03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III"
			},
			{
				"name":"Cytochrome c oxidase",
				"children":[
				{
					"name":"PY17X_1015300 cytochrome c oxidase subunit 2, putative\tK02261 COX2; cytochrome c oxidase subunit 2"
				}
				]
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase",
				"children":[
				{
					"name":"PY17X_0925000 DNA-dependent RNA polymerase\tK10908 POLRMT; DNA-directed RNA polymerase, mitochondrial [EC:2.7.7.6]"
				}
				]
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"PY17X_0703900 translation initiation factor IF-2, putative\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"PY17X_1234800 uncharacterized protein\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"PY17X_0405700 elongation factor (EF-TS), putative\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"PY17X_1350400 elongation factor Tu, putative\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"PY17X_0102800 elongation factor G, putative\tK02355 fusA; elongation factor G"
				},
				{
					"name":"PY17X_1450200 elongation factor G, putative\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP",
				"children":[
				{
					"name":"PY17X_1223300 ribonucleases P\/MRP protein subunit POP1, putative\tK01164 POP1; ribonuclease P\/MRP protein subunit POP1 [EC:3.1.26.5]"
				},
				{
					"name":"PY17X_1128100 ribonuclease P protein subunit p29, putative\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"PY17X_0937900 conserved Plasmodium protein, unknown function\tK14530 RPP40; ribonucleases P\/MRP protein subunit RPP40 [EC:3.1.26.5]"
				}
				]
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"PY17X_1309400 uncharacterized protein\tK18156 ATP23; mitochondrial inner membrane protease ATP23 [EC:3.4.24.-]"
				},
				{
					"name":"PY17X_1124000 helicase\tK17675 SUPV3L1; ATP-dependent RNA helicase SUPV3L1\/SUV3 [EC:5.6.2.6]"
				},
				{
					"name":"PY17X_0521300 ADP\/ATP transporter on adenylate translocase, putative\tK05863 SLC25A4S; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4\/5\/6\/31"
				},
				{
					"name":"PY17X_1010600 GTPase Era, putative\tK03595 era; GTPase"
				},
				{
					"name":"PY17X_0932500 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"PY17X_1226000 tyrosine--tRNA ligase, putative\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"PY17X_0702800 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"PY17X_1123100 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"PY17X_1115100 aspartate--tRNA ligase, putative\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"PY17X_1024700 glycine--tRNA ligase, putative\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"PY17X_1436600 arginine--tRNA ligase, putative\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"PY17X_1009900 uncharacterized protein\tK19828 MTG1; mitochondrial GTPase 1"
				},
				{
					"name":"PY17X_0938600 conserved Plasmodium protein, unknown function\tK21970 NSUN4; 5-methylcytosine rRNA methyltransferase NSUN4 [EC:2.1.1.-]"
				},
				{
					"name":"PY17X_1008700 peptide chain release factor 2, putative\tK23498 COXPD7; peptide chain release factor"
				},
				{
					"name":"PY17X_0504100 conserved protein, unknown function\tK23499 RMND1; required for meiotic nuclear division protein 1"
				},
				{
					"name":"PY17X_0517500 uncharacterized protein\tK23499 RMND1; required for meiotic nuclear division protein 1"
				},
				{
					"name":"PY17X_1126900 uncharacterized protein\tK25877 MYG1; MYG1 exonuclease [EC:3.1.-.-]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"PY17X_1109500 uncharacterized protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"PY17X_0807700 AAA family ATPase, putative\tK17681 ATAD3A_B; ATPase family AAA domain-containing protein 3A\/B"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors",
				"children":[
				{
					"name":"PY17X_0613400 uncharacterized protein\tK09503 DNAJA2; DnaJ homolog subfamily A member 2"
				},
				{
					"name":"PY17X_0712100 heat shock protein 70, putative\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
				}
				]
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex",
				"children":[
				{
					"name":"PY17X_1117700 mitochondrial import receptor subunit Tom40 homolog\tK11518 TOM40; mitochondrial import receptor subunit TOM40"
				}
				]
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"PY17X_0108500 sorting assembly machinery 50 kDa subunit, putative\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex",
				"children":[
				{
					"name":"PY17X_1145800 mitochondrial import inner membrane translocase subunit TIM9, putative\tK17777 TIM9; mitochondrial import inner membrane translocase subunit TIM9"
				},
				{
					"name":"PY17X_0609600 uncharacterized protein\tK17778 TIM10; mitochondrial import inner membrane translocase subunit TIM10"
				}
				]
			},
			{
				"name":"TIM8\/13 complex",
				"children":[
				{
					"name":"PY17X_1458800 mitochondrial import inner membrane translocase subunit TIM13, putative\tK17780 TIM8; mitochondrial import inner membrane translocase subunit TIM8"
				},
				{
					"name":"PY17X_1103700 Tim10\/DDP family zinc finger protein, putative\tK17781 TIM13; mitochondrial import inner membrane translocase subunit TIM13"
				}
				]
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex",
				"children":[
				{
					"name":"PY17X_0204800 FAD-linked sulfhydryl oxidase ERV1, putative\tK17783 ERV1; mitochondrial FAD-linked sulfhydryl oxidase [EC:1.8.3.2]"
				}
				]
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex",
				"children":[
				{
					"name":"PY17X_1127600 mitochondrial import inner membrane translocase subunit TIM22, putative\tK17790 TIM22; mitochondrial import inner membrane translocase subunit TIM22"
				}
				]
			},
			{
				"name":"TIM23 complex",
				"children":[
				{
					"name":"PY17X_1134000 mitochondrial import inner membrane translocase subunit TIM23, putative\tK17794 TIM23; mitochondrial import inner membrane translocase subunit TIM23"
				},
				{
					"name":"PY17X_1011700 mitochondrial import inner membrane translocase subunit Tim17\tK17795 TIM17; mitochondrial import inner membrane translocase subunit TIM17"
				},
				{
					"name":"PY17X_0212400 uncharacterized protein\tK17496 TIM50; mitochondrial import inner membrane translocase subunit TIM50"
				}
				]
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors",
				"children":[
				{
					"name":"PY17X_0719400 LETM1-like protein, putative\tK17800 LETM1; mitochondrial proton\/calcium exchanger protein"
				},
				{
					"name":"PY17X_1006100 methyltransferase, putative\tK17803 OMS1; methyltransferase OMS1, mitochondrial [EC:2.1.1.-]"
				},
				{
					"name":"PY17X_1359600 mitochondrial pyruvate carrier protein 1, putative\tK22138 MPC1; mitochondrial pyruvate carrier 1"
				},
				{
					"name":"PY17X_1338300 mitochondrial pyruvate carrier protein 2, putative\tK22139 MPC2; mitochondrial pyruvate carrier 2"
				}
				]
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"PY17X_0924900 uncharacterized protein\tK17804 TIM44; mitochondrial import inner membrane translocase subunit TIM44"
				},
				{
					"name":"PY17X_0915900 heat shock protein hsp70\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"PY17X_0925600 GrpE protein homolog, mitochondrial, putative\tK03687 GRPE; molecular chaperone GrpE"
				},
				{
					"name":"PY17X_0624600 mitochondrial import inner membrane translocase subunit TIM14, putative\tK09539 DNAJC19; DnaJ homolog subfamily C member 19"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"PY17X_1241100 mitochondrial processing peptidase subunit alpha homolog\tK01412 PMPCA; mitochondrial-processing peptidase subunit alpha [EC:3.4.24.64]"
				},
				{
					"name":"PY17X_0837800 mitochondrial-processing peptidase subunit beta, putative\tK17732 PMPCB; mitochondrial-processing peptidase subunit beta [EC:3.4.24.64]"
				},
				{
					"name":"PY17X_1355900 mitochondrial intermediate peptidase, putative\tK01410 MIPEP; mitochondrial intermediate peptidase [EC:3.4.24.59]"
				},
				{
					"name":"PY17X_1217200 heat shock protein 60, putative\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"PY17X_1449300 60 kDa chaperonin, putative\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"PY17X_1433300 10 kDa chaperonin, putative\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"PY17X_1008400 uncharacterized protein\tK03686 dnaJ; molecular chaperone DnaJ"
				},
				{
					"name":"PY17X_1024800 uncharacterized protein\tK17808 ZIM17; mitochondrial protein import protein ZIM17"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"PY17X_0102800 elongation factor G, putative\tK02355 fusA; elongation factor G"
				},
				{
					"name":"PY17X_1450200 elongation factor G, putative\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"PY17X_0212700 cysteine desulfurase, putative\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"PY17X_1322000 uncharacterized protein\tK22068 ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial"
				},
				{
					"name":"PY17X_1411300 protein ISD11, putative\tK22069 LYRM4; LYR motif-containing protein 4"
				},
				{
					"name":"PY17X_1432600 adrenodoxin-type ferredoxin, putative\tK22071 FDX2; ferredoxin-2, mitochondrial"
				},
				{
					"name":"PY17X_0910700 uncharacterized protein\tK18914 FDXR; adrenodoxin-NADP+ reductase [EC:1.18.1.6]"
				},
				{
					"name":"PY17X_0915900 heat shock protein hsp70\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"PY17X_0824300 chaperone, putative\tK04082 hscB; molecular chaperone HscB"
				},
				{
					"name":"PY17X_0405300 1-cys-glutaredoxin protein-1\tK07390 grxD; monothiol glutaredoxin"
				},
				{
					"name":"PY17X_1219200 uncharacterized protein\tK22063 ISCA1; iron-sulfur cluster assembly 1"
				},
				{
					"name":"PY17X_1240700 iron-sulfur assembly protein, putative\tK22063 ISCA1; iron-sulfur cluster assembly 1"
				},
				{
					"name":"PY17X_0305200 iron-sulfur assembly protein, putative\tK22072 ISCA2; iron-sulfur cluster assembly 2"
				},
				{
					"name":"PY17X_0835100 NifU-like protein, putative\tK22074 NFU1; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis",
				"children":[
				{
					"name":"PY17X_1030200 ATP-dependent protease, putative\tK08675 LONP1; ATP-dependent Lon protease [EC:3.4.21.53]"
				},
				{
					"name":"PY17X_0941900 prefoldin, putative\tK26537 UXT; protein UXT"
				},
				{
					"name":"PY17X_1218400 conserved protein, unknown function\tK28271 C2ORF69; mitochondrial protein C2orf69"
				},
				{
					"name":"PY17X_0315600 ATP-dependent RNA helicase DDX47, putative\tK14777 DDX47; ATP-dependent RNA helicase DDX47\/RRP3 [EC:5.6.2.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors"
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors",
				"children":[
				{
					"name":"PY17X_0103600 uncharacterized protein\tK08900 BCS1; mitochondrial chaperone BCS1"
				}
				]
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"PY17X_0215100 conserved Plasmodium protein, unknown function\tK18171 CMC1; COX assembly mitochondrial protein 1"
				},
				{
					"name":"PY17X_0806500 conserved protein, unknown function\tK18177 COA4; cytochrome c oxidase assembly factor 4"
				},
				{
					"name":"PY17X_0705300 cytochrome c oxidase assembly factor 5, putative\tK18178 COA5; cytochrome c oxidase assembly factor 5"
				},
				{
					"name":"PY17X_1237500 protoheme IX farnesyltransferase, putative\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"PY17X_1304500 uncharacterized protein\tK02258 COX11; cytochrome c oxidase assembly protein subunit 11"
				},
				{
					"name":"PY17X_1011400 cytochrome c oxidase assembly protein COX15, putative\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"PY17X_0510900 cytochrome c oxidase copper chaperone, putative\tK02260 COX17; cytochrome c oxidase assembly protein subunit 17"
				},
				{
					"name":"PY17X_0603400 uncharacterized protein\tK18183 COX19; cytochrome c oxidase assembly protein subunit 19"
				},
				{
					"name":"PY17X_1325600 protein PET117, putative\tK18188 PET117; protein PET117"
				},
				{
					"name":"PY17X_0702600 mitochondrial inner membrane protein OXA1, putative\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"PY17X_1222600 uncharacterized protein\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors",
				"children":[
				{
					"name":"PY17X_0610700 ATP synthase mitochondrial F1 complex assembly factor 1, putative\tK07555 ATPeAF1; ATP synthase mitochondrial F1 complex assembly factor 1"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors",
				"children":[
				{
					"name":"PY17X_1326700 uncharacterized protein\tK23166 OPA3; optic atrophy 3 protein"
				},
				{
					"name":"PY17X_0203300 conserved protein, unknown function\tK17968 TRIAP1; TRIAP1\/MDM35 family protein"
				},
				{
					"name":"PY17X_0521500 uncharacterized protein\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]"
				},
				{
					"name":"PY17X_1345400 mitochondrial fission 1 protein, putative\tK17969 FIS1; mitochondrial fission 1 protein"
				}
				]
			},
			{
				"name":"Actin cytoskeleton organization",
				"children":[
				{
					"name":"PY17X_0205500 uncharacterized protein\tK17972 NAA20; N-terminal acetyltransferase B complex catalytic subunit [EC:2.3.1.254]"
				}
				]
			},
			{
				"name":"Mitochondrial movement",
				"children":[
				{
					"name":"PY17X_0701800 prohibitin 1, putative\tK17080 PHB1; prohibitin 1"
				},
				{
					"name":"PY17X_1216300 uncharacterized protein\tK17081 PHB2; prohibitin 2"
				}
				]
			},
			{
				"name":"Retention of mitochondria",
				"children":[
				{
					"name":"PY17X_0521500 uncharacterized protein\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]"
				}
				]
			},
			{
				"name":"Morphogenesis factors",
				"children":[
				{
					"name":"PY17X_1312900 mitochondrial ribosomal protein S29 precursor, putative\tK17408 DAP3; small subunit ribosomal protein S29"
				}
				]
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins",
				"children":[
				{
					"name":"PY17X_0418500 autophagy-related protein 3, putative\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
				},
				{
					"name":"PY17X_0505200 uncharacterized protein\tK08341 GABARAP; GABA(A) receptor-associated protein"
				},
				{
					"name":"PY17X_1337900 autophagy-related protein 12, putative\tK08336 ATG12; ubiquitin-like protein ATG12"
				}
				]
			},
			{
				"name":"Parkin-dependent mechanism factors",
				"children":[
				{
					"name":"PY17X_1119300 conserved protein, unknown function\tK19513 CLEC16A; protein CLEC16A"
				}
				]
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"PY17X_0808800 heat shock protein 90, putative\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}