{
	"name":"pyu03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"121027127 ORC1; origin recognition complex subunit 1 isoform X1\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"121030898 ORC2; origin recognition complex subunit 2\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"121029759 ORC3; origin recognition complex subunit 3 isoform X1\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"121030538 ORC4; origin recognition complex subunit 4 isoform X1\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"121028848 ORC5; origin recognition complex subunit 5 isoform X1\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"121045236 ORC6; origin recognition complex subunit 6 isoform X1\tK02608 ORC6; origin recognition complex subunit 6"
				},
				{
					"name":"121009983 CDT1; DNA replication factor Cdt1\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"121044933 CDC6; cell division control protein 6 homolog isoform X1\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"121022291 MCM2; DNA replication licensing factor MCM2\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"121029573 MCM3; DNA replication licensing factor MCM3\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"121038292 MCM4; DNA replication licensing factor MCM4\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"121040432 MCM5; DNA replication licensing factor MCM5\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"121030496 MCM6; DNA replication licensing factor MCM6\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"121017598 MCM7; DNA replication licensing factor MCM7 isoform X1\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)",
				"children":[
				{
					"name":"121012858 CCNA1; cyclin-A1 isoform X1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"121030311 CCNA2; cyclin-A2\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"121011326 CCNE1; G1\/S-specific cyclin-E1\tK06626 CCNE; G1\/S-specific cyclin-E1"
				},
				{
					"name":"121042720 CCNE2; G1\/S-specific cyclin-E2 isoform X1\tK06626 CCNE; G1\/S-specific cyclin-E1"
				},
				{
					"name":"121040954 CDK2; cyclin-dependent kinase 2 isoform X1\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"
				}
				]
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"121027466 CDC7; cell division cycle 7-related protein kinase isoform X1\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				},
				{
					"name":"121028769 DBF4; protein DBF4 homolog A isoform X1\tK06629 DBF4; protein DBF4"
				},
				{
					"name":"121045107 DBF4B; protein DBF4 homolog B\tK06629 DBF4; protein DBF4"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"121012586 GINS1; DNA replication complex GINS protein PSF1 isoform X1\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"121009886 GINS2; DNA replication complex GINS protein PSF2\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"121045382 GINS3; DNA replication complex GINS protein PSF3\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"121014948 GINS4; DNA replication complex GINS protein SLD5\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"121033693 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
				},
				{
					"name":"121043157 RECQL4; ATP-dependent DNA helicase Q4 isoform X1\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
				},
				{
					"name":"121023321 CDC45; cell division control protein 45 homolog\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"121012465 MCM8; DNA helicase MCM8 isoform X1\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
				},
				{
					"name":"121029980 MCM9; DNA helicase MCM9 isoform X1\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
				},
				{
					"name":"121014801 MCM10; protein MCM10 homolog\tK10736 MCM10; minichromosome maintenance protein 10"
				},
				{
					"name":"121037306 mini-chromosome maintenance complex-binding protein isoform X1\tK28390 MCMBP; minichromosome maintenance complex-binding protein"
				},
				{
					"name":"121040797 HELB; DNA helicase B isoform X1\tK15254 HELB; DNA helicase B [EC:5.6.2.3]"
				},
				{
					"name":"121043382 FAM111A; serine protease FAM111A\tK24274 FAM111A; protein FAM111A"
				},
				{
					"name":"121032316 cyclin-dependent kinase 2-interacting protein isoform X1\tK26052 CINP; cyclin-dependent kinase 2-interacting protein"
				},
				{
					"name":"121042914 mdm2-binding protein isoform X1\tK26116 MTBP; Mdm2-binding protein"
				},
				{
					"name":"121042392 TICRR; treslin\tK26117 TICRR; Treslin"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"121026052 POLA1; DNA polymerase alpha catalytic subunit isoform X1\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"121023927 POLA2; DNA polymerase alpha subunit B isoform X1\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"121040904 PRIM1; DNA primase small subunit\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"121029620 PRIM2; DNA primase large subunit isoform X1\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"121022739 POLE; DNA polymerase epsilon catalytic subunit A\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"121031723 POLE2; DNA polymerase epsilon subunit 2 isoform X1\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				},
				{
					"name":"121034863 POLE3; DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
				},
				{
					"name":"121019207 POLE4; DNA polymerase epsilon subunit 4 isoform X1\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"121018920 POLD1; DNA polymerase delta catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"121016939 POLD2; DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"121039275 POLD3; DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
				},
				{
					"name":"121023664 POLD4; DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"121042405 POLG; DNA polymerase subunit gamma-1 isoform X1\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				},
				{
					"name":"121015286 POLG2; DNA polymerase subunit gamma-2, mitochondrial isoform X1\tK02333 POLG2; DNA polymerase gamma 2"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"121017318 RPA1; replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"121024292 RPA2; replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"121028691 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"121036849 RFC1; replication factor C subunit 1\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"121017751 RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"121034127 RFC4; replication factor C subunit 4 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"121010266 RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"121012843 RFC3; replication factor C subunit 3 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"121044040 RNASEH1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"121014047 ribonuclease H2 subunit A isoform X1\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				},
				{
					"name":"121012927 RNASEH2B; ribonuclease H2 subunit B isoform X1\tK10744 RNASEH2B; ribonuclease H2 subunit B"
				},
				{
					"name":"121023636 RNASEH2C; ribonuclease H2 subunit C\tK10745 RNASEH2C; ribonuclease H2 subunit C"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"121012455 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"121041826 PCLAF; PCNA-associated factor isoform X1\tK28763 PCLAF; PCNA-associated factor"
				},
				{
					"name":"121036706 DNA2; DNA replication ATP-dependent helicase\/nuclease DNA2 isoform X1\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"121043315 FEN1; flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"121015102 EXO1; exonuclease 1 isoform X1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"121030488 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				},
				{
					"name":"121018881 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				},
				{
					"name":"121017156 ATAD5; ATPase family AAA domain-containing protein 5\tK26118 ATAD5; ATPase family AAA domain-containing protein 5"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"121013960 DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"121044206 DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1\tK17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]"
				},
				{
					"name":"121012317 DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1\tK17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"121020616 GMNN; geminin\tK10749 GMNN; geminin"
				},
				{
					"name":"121015937 MCIDAS; multicilin\tK26119 MCIDAS; multicilin"
				},
				{
					"name":"121014916 CCNB1; G2\/mitotic-specific cyclin-B1\tK05868 CCNB1; G2\/mitotic-specific cyclin-B1"
				},
				{
					"name":"121041777 CCNB2; G2\/mitotic-specific cyclin-B2 isoform X1\tK21770 CCNB2; G2\/mitotic-specific cyclin-B2"
				},
				{
					"name":"121025949 CCNB3; G2\/mitotic-specific cyclin-B3 isoform X1\tK21771 CCNB3; G2\/mitotic-specific cyclin-B3"
				},
				{
					"name":"121036668 CDK1; cyclin-dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]"
				}
				]
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex",
					"children":[
					{
						"name":"121028397 POT1; protection of telomeres protein 1\tK11109 POT1; protection of telomeres protein 1"
					},
					{
						"name":"121038123 TERF1; telomeric repeat-binding factor 1 isoform X1\tK11110 TERF1; telomeric repeat-binding factor 1"
					},
					{
						"name":"121009718 TERF2; telomeric repeat-binding factor 2\tK11111 TERF2; telomeric repeat-binding factor 2"
					},
					{
						"name":"121031562 TINF2; TERF1-interacting nuclear factor 2 isoform X1\tK11112 TINF2; TERF1-interacting nuclear factor 2"
					},
					{
						"name":"121009812 telomeric repeat-binding factor 2-interacting protein 1\tK11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1"
					},
					{
						"name":"121045461 ACD; adrenocortical dysplasia protein homolog isoform X1\tK11114 ACD; adrenocortical dysplasia protein"
					}
					]
				},
				{
					"name":"TERB1-TERB2-MAJIN complex",
					"children":[
					{
						"name":"121045416 TERB1; telomere repeats-binding bouquet formation protein 1 isoform X1\tK25749 TERB1; telomere repeats-binding bouquet formation protein 1"
					},
					{
						"name":"121041632 TERB2; telomere repeats-binding bouquet formation protein 2 isoform X1\tK25750 TERB2; telomere repeats-binding bouquet formation protein 2"
					},
					{
						"name":"121023816 MAJIN; membrane-anchored junction protein isoform X1\tK25751 MAJIN; membrane-anchored junction protein"
					}
					]
				},
				{
					"name":"CST complex (animals)",
					"children":[
					{
						"name":"121015944 CTC1; CST complex subunit CTC1\tK23311 CTC1; CST complex subunit CTC1"
					},
					{
						"name":"121037193 STN1; CST complex subunit STN1 isoform X1\tK23312 STN1; CST complex subunit STN1"
					},
					{
						"name":"121017945 TEN1; CST complex subunit TEN1 isoform X1\tK23313 TEN1; CST complex subunit TEN1"
					}
					]
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"121017327 SMG6; telomerase-binding protein EST1A isoform X1\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
				},
				{
					"name":"121015600 SMG5; protein SMG5 isoform X1\tK11125 SMG5; protein SMG5"
				},
				{
					"name":"121042092 TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"121031397 TEP1; telomerase protein component 1 isoform X1\tK11127 TEP1; telomerase protein component 1"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"121031056 GAR1; H\/ACA ribonucleoprotein complex subunit 1\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"121041845 LOW QUALITY PROTEIN: H\/ACA ribonucleoprotein complex subunit 1-like\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"121026832 H\/ACA ribonucleoprotein complex subunit 2\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"121026835 H\/ACA ribonucleoprotein complex subunit 2\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"121026836 H\/ACA ribonucleoprotein complex subunit 2-like\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"121026838 H\/ACA ribonucleoprotein complex subunit 2-like\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"121033895 H\/ACA ribonucleoprotein complex subunit 3-like\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"121041435 NOP10; H\/ACA ribonucleoprotein complex subunit 3\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"121024829 DKC1; H\/ACA ribonucleoprotein complex subunit DKC1\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"121042092 TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"121012404 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"121033106 SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"121018628 SNRPD2; small nuclear ribonucleoprotein Sm D2\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"121010155 SNRPD3; small nuclear ribonucleoprotein Sm D3\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"121031740 small nuclear ribonucleoprotein Sm D3-like\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"121021701 SNRPE; small nuclear ribonucleoprotein E isoform X1\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"121031299 small nuclear ribonucleoprotein F-like\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"121040584 SNRPF; small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"121011216 small nuclear ribonucleoprotein G-like\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"121018686 small nuclear ribonucleoprotein G-like\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"121019290 SNRPG; small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"121032677 small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"121035837 small nuclear ribonucleoprotein G-like\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"121036797 small nuclear ribonucleoprotein G-like\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"121017751 RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"121034127 RFC4; replication factor C subunit 4 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"121010266 RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"121012843 RFC3; replication factor C subunit 3 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"121039431 MRE11; double-strand break repair protein MRE11 isoform X1\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"121010678 RAD50; DNA repair protein RAD50 isoform X1\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
				},
				{
					"name":"121042673 NBN; nibrin isoform X1\tK10867 NBN; nibrin"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"121035348 ATM; serine-protein kinase ATM isoform X1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"121039799 WRN; Werner syndrome ATP-dependent helicase isoform X1\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
				},
				{
					"name":"121042354 BLM; Bloom syndrome protein isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"121038294 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
				},
				{
					"name":"121019498 ERCC4; DNA repair endonuclease XPF\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"121015149 PARP1; poly [ADP-ribose] polymerase 1 isoform X1\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
				},
				{
					"name":"121031398 PARP2; poly [ADP-ribose] polymerase 2 isoform X1\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
				},
				{
					"name":"121037459 TNKS2; poly [ADP-ribose] polymerase tankyrase-2\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"121039778 TNKS; poly [ADP-ribose] polymerase tankyrase-1 isoform X1\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"121026921 PINX1; PIN2\/TERF1-interacting telomerase inhibitor 1 isoform X1\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"121020046 RTEL1; regulator of telomere elongation helicase 1 isoform X1\tK11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]"
				},
				{
					"name":"121019720 TELO2; telomere length regulation protein TEL2 homolog\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"121014038 TRIR; telomerase RNA component interacting RNase isoform X1\tK01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]"
				},
				{
					"name":"121030556 RIF1; telomere-associated protein RIF1 isoform X1\tK11138 RIF1; telomere-associated protein RIF1"
				},
				{
					"name":"121041835 PIF1; ATP-dependent DNA helicase PIF1 isoform X1\tK15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]"
				},
				{
					"name":"121010799 PURA; transcriptional activator protein Pur-alpha\tK21772 PURA; transcriptional activator protein Pur-alpha"
				},
				{
					"name":"121039798 PURG; purine-rich element-binding protein gamma isoform X1\tK21800 PURG; purine-rich element-binding protein gamma"
				},
				{
					"name":"121015980 WRAP53; telomerase Cajal body protein 1\tK23314 WRAP53; telomerase Cajal body protein 1"
				},
				{
					"name":"121015160 SDE2; replication stress response regulator SDE2\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"121019884 RTF2; replication termination factor 2 isoform X1\tK25186 RTF2; replication termination factor 2"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"121012191 TOP1; DNA topoisomerase 1\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"121033580 TOP2B; DNA topoisomerase 2-beta isoform X1\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"121044941 TOP2A; DNA topoisomerase 2-alpha\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"121015816 TOP3A; DNA topoisomerase 3-alpha isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"121023055 TOP3B; DNA topoisomerase 3-beta-1 isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"121028229 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"121044040 RNASEH1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"121044040 RNASEH1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"121036706 DNA2; DNA replication ATP-dependent helicase\/nuclease DNA2 isoform X1\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"121043315 FEN1; flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"121018881 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	}
	]
}