{ "name":"ray03019", "children":[ { "name":"Eukaryotic type", "children":[ { "name":"mRNA processing factors", "children":[ { "name":"5' end processing", "children":[ { "name":"Capping factors", "children":[ { "name":"107497728 RNMT; mRNA cap guanine-N7 methyltransferase\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]" }, { "name":"107508669 RNGTT; mRNA-capping enzyme isoform X1\tK13917 RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74]" }, { "name":"107498728 CDK7; cyclin-dependent kinase 7 isoform X1\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]" }, { "name":"107514694 CMTR1; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 isoform X1\tK14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57]" }, { "name":"107520520 CMTR2; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2\tK14590 CMTR2; cap2 methyltransferase [EC:2.1.1.296]" }, { "name":"107505335 RAMAC; RNA guanine-N7 methyltransferase activating subunit\tK18708 FAM103A1; RNMT-activating mini protein" } ] }, { "name":"Cap binding complex", "children":[ { "name":"107511680 NCBP1; nuclear cap-binding protein subunit 1 isoform X1\tK12882 NCBP1; nuclear cap-binding protein subunit 1" }, { "name":"107505278 NCBP2; nuclear cap-binding protein subunit 2 isoform X2\tK12883 NCBP2; nuclear cap-binding protein subunit 2" } ] } ] }, { "name":"3' end processing", "children":[ { "name":"Pre-mRNA cleavage factor Im (CFIm)", "children":[ { "name":"107499660 NUDT21; cleavage and polyadenylation specificity factor subunit 5\tK14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5" }, { "name":"107504404 CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7" }, { "name":"107504754 CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7" } ] }, { "name":"Pre-mRNA cleavage factor IIm (CFIIm)", "children":[ { "name":"107518402 CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1\tK14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]" }, { "name":"107518550 PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1\tK14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11" } ] }, { "name":"Cleavage and polyadenylation specificity factor (CPSF) complex", "children":[ { "name":"107503490 CPSF1; cleavage and polyadenylation specificity factor subunit 1 isoform X1\tK14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1" }, { "name":"107511237 CPSF2; cleavage and polyadenylation specificity factor subunit 2 isoform X2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2" }, { "name":"107498265 CPSF3; cleavage and polyadenylation specificity factor subunit 3\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]" }, { "name":"107510266 CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4" }, { "name":"107517856 CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4" }, { "name":"107497595 FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X2\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1" }, { "name":"107516874 WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1\tK15542 PFS2; polyadenylation factor subunit 2" }, { "name":"107498578 WDR82; WD repeat-containing protein 82\tK14962 WDR82; COMPASS component SWD2" }, { "name":"107503728 PPP1CA; serine\/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"107511165 PPP1CB; serine\/threonine-protein phosphatase PP1-beta catalytic subunit\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"107513247 PPP1CC; serine\/threonine-protein phosphatase PP1-gamma catalytic subunit\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"107509714 RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]" }, { "name":"107510696 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]" }, { "name":"107521310 LOW QUALITY PROTEIN: RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]" }, { "name":"118607871 RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]" } ] }, { "name":"Cleavage stimulation factor (CSTF) complex", "children":[ { "name":"107504723 CSTF1; cleavage stimulation factor subunit 1\tK14406 CSTF1; cleavage stimulation factor subunit 1" }, { "name":"107503352 CSTF2; cleavage stimulation factor subunit 2 isoform X1\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"107515479 CSTF2T; cleavage stimulation factor subunit 2 tau variant\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"107512020 CSTF3; cleavage stimulation factor subunit 3\tK14408 CSTF3; cleavage stimulation factor subunit 3" }, { "name":"107515978 SYMPK; symplekin isoform X1\tK06100 SYMPK; symplekin" } ] }, { "name":"U7-dependent histone pre-mRNA processing factors", "children":[ { "name":"107511327 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'" }, { "name":"107500684 SNRPD3; small nuclear ribonucleoprotein Sm D3\tK11088 SNRPD3; small nuclear ribonucleoprotein D3" }, { "name":"107498247 small nuclear ribonucleoprotein E-like\tK11097 SNRPE; small nuclear ribonucleoprotein E" }, { "name":"107508177 SNRPE; small nuclear ribonucleoprotein E\tK11097 SNRPE; small nuclear ribonucleoprotein E" }, { "name":"107518056 SNRPF; small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F" }, { "name":"107519110 SNRPG; small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G" }, { "name":"107512078 LSM10; U7 snRNA-associated Sm-like protein LSm10\tK25591 LSM10; U7 snRNA-associated Sm-like protein LSm10" }, { "name":"107521879 LSM11; U7 snRNA-associated Sm-like protein LSm11 isoform X1\tK25592 LSM11; U7 snRNA-associated Sm-like protein LSm11" }, { "name":"107511237 CPSF2; cleavage and polyadenylation specificity factor subunit 2 isoform X2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2" }, { "name":"107498265 CPSF3; cleavage and polyadenylation specificity factor subunit 3\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]" }, { "name":"107503352 CSTF2; cleavage stimulation factor subunit 2 isoform X1\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"107515479 CSTF2T; cleavage stimulation factor subunit 2 tau variant\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"107515978 SYMPK; symplekin isoform X1\tK06100 SYMPK; symplekin" }, { "name":"107518023 histone RNA hairpin-binding protein isoform X1\tK18710 SLBP; histone RNA hairpin-binding protein" }, { "name":"107518731 oocyte-specific histone RNA stem-loop-binding protein 2\tK18710 SLBP; histone RNA hairpin-binding protein" }, { "name":"107508650 CASP8AP2; CASP8-associated protein 2 isoform X1\tK25593 CASP8AP2; CASP8-associated protein 2" } ] }, { "name":"DRB sensitivity inducing factor (DSIF) complex", "children":[ { "name":"107499169 SUPT4H1; transcription elongation factor SPT4\tK15171 SUPT4H1; transcription elongation factor SPT4" }, { "name":"107521801 SUPT5H; transcription elongation factor SPT5 isoform X1\tK15172 SUPT5H; transcription elongation factor SPT5" } ] }, { "name":"N6-methyltransferase complex", "children":[ { "name":"107521144 METTL3; N6-adenosine-methyltransferase catalytic subunit\tK05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]" }, { "name":"107510887 METTL14; N6-adenosine-methyltransferase non-catalytic subunit isoform X1\tK23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit" }, { "name":"107516755 METTL4; N(6)-adenine-specific methyltransferase METTL4 isoform X1\tK24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]" }, { "name":"107507706 METTL16; RNA N6-adenosine-methyltransferase METTL16 isoform X1\tK11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]" }, { "name":"107514728 pre-mRNA-splicing regulator WTAP isoform X1\tK22824 WTAP; pre-mRNA-splicing regulator WTAP" }, { "name":"107516372 VIRMA; protein virilizer homolog isoform X1\tK22910 VIRMA; protein virilizer" }, { "name":"107504141 RBM15B; putative RNA-binding protein 15B\tK13190 RBM15; RNA-binding protein 15" }, { "name":"107516129 RBM15; RNA-binding protein 15 isoform X1\tK13190 RBM15; RNA-binding protein 15" }, { "name":"107519098 ZC3H13; zinc finger CCCH domain-containing protein 13 isoform X1\tK22909 ZC3H13; zinc finger CCCH domain-containing protein 13" }, { "name":"107501117 CBLL1; E3 ubiquitin-protein ligase Hakai isoform X1\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]" } ] }, { "name":"Poly(A) addition factors", "children":[ { "name":"107502440 PAPOLG; poly(A) polymerase gamma isoform X1\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"107505305 PAPOLB; poly(A) polymerase beta\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"107518322 PAPOLA; poly(A) polymerase alpha isoform X1\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"107497240 TENT2; poly(A) RNA polymerase GLD2 isoform X1\tK14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]" }, { "name":"107501567 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase\tK18709 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase [EC:2.7.7.19 2.7.7.52]" } ] }, { "name":"Negative regulators of mRNA 3' end processing", "children":[ { "name":"107513399 BARD1; BRCA1-associated RING domain protein 1 isoform X1\tK10683 BARD1; BRCA1-associated RING domain protein 1" }, { "name":"107518899 RBM26; RNA-binding protein 26 isoform X1\tK13192 RBM26; RNA-binding protein 26" }, { "name":"107509671 FTO; alpha-ketoglutarate-dependent dioxygenase FTO isoform X2\tK19469 FTO; mRNA N6-methyladenine demethylase [EC:1.14.11.53]" }, { "name":"107511087 ALKBH5; RNA demethylase ALKBH5\tK10767 ALKBH5; mRNA N6-methyladenine demethylase [EC:1.14.11.53]" }, { "name":"107513107 TAR DNA-binding protein 43\tK23600 TARDBP; TAR DNA-binding protein 43" } ] } ] }, { "name":"Other processing factors", "children":[ { "name":"107510142 DHX40; probable ATP-dependent RNA helicase DHX40\tK18711 DHX40; ATP-dependent RNA helicase DHX40 [EC:5.6.2.6]" }, { "name":"107505972 KIN; DNA\/RNA-binding protein KIN17\tK13102 KIN; DNA\/RNA-binding protein KIN17" }, { "name":"107499573 METTL8; mRNA N(3)-methylcytidine methyltransferase METTL8\tK24975 METTL8; mRNA N(3)-methylcytidine methyltransferase METTL8 [EC:2.1.1.-]" }, { "name":"107515377 METTL22; methyltransferase-like protein 22 isoform X1\tK23040 METTL22; methyltransferase-like protein 22 [EC:2.1.1.-]" }, { "name":"107503604 TENT5B; terminal nucleotidyltransferase 5B\tK23033 TENT5A_B; terminal nucleotidyltransferase 5A\/B [EC:2.7.7.-]" }, { "name":"107513202 TENT5A; terminal nucleotidyltransferase 5A isoform X1\tK23033 TENT5A_B; terminal nucleotidyltransferase 5A\/B [EC:2.7.7.-]" }, { "name":"107518839 TENT5C; terminal nucleotidyltransferase 5C\tK23034 TENT5C; terminal nucleotidyltransferase 5C [EC:2.7.7.19]" }, { "name":"107520763 TENT5D; terminal nucleotidyltransferase 5D\tK23035 TENT5D; terminal nucleotidyltransferase 5D [EC:2.7.7.19]" }, { "name":"107499534 ZC3H14; zinc finger CCCH domain-containing protein 14 isoform X1\tK23038 ZC3H14; zinc finger CCCH domain-containing protein 14" }, { "name":"107500004 SRRT; serrate RNA effector molecule homolog isoform X1\tK27103 SRRT; serrate RNA effector molecule" } ] } ] }, { "name":"mRNA surveillance and transport factors", "children":[ { "name":"Transport factors", "children":[ { "name":"EJC complex", "children":[ { "name":"107509974 RBM8A; RNA-binding protein 8A isoform X1\tK12876 RBM8A; RNA-binding protein 8A" }, { "name":"107497965 MAGOH; protein mago nashi homolog\tK12877 MAGOH; protein mago nashi" }, { "name":"107516571 MAGOHB; protein mago nashi homolog 2 isoform X1\tK12877 MAGOH; protein mago nashi" }, { "name":"107520286 ALYREF; THO complex subunit 4\tK12881 THOC4; THO complex subunit 4" }, { "name":"107498472 DDX39B; spliceosome RNA helicase DDX39B\tK12812 DDX39B; ATP-dependent RNA helicase UAP56\/SUB2 [EC:5.6.2.7]" }, { "name":"107510084 EIF4A3; eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"107498681 CCDC174; coiled-coil domain-containing protein 174\tK25178 CCDC174; coiled-coil domain-containing protein 174" }, { "name":"107520669 CASC3; protein CASC3\tK14323 CASC3; protein CASC3" }, { "name":"107514403 SAP18; histone deacetylase complex subunit SAP18\tK14324 SAP18; histone deacetylase complex subunit SAP18" }, { "name":"107520801 histone deacetylase complex subunit SAP18-like\tK14324 SAP18; histone deacetylase complex subunit SAP18" }, { "name":"107507495 PNN; pinin\tK13114 PNN; pinin" }, { "name":"107497999 ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X4\tK12875 ACIN1; apoptotic chromatin condensation inducer in the nucleus" }, { "name":"107506044 RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1\tK14325 RNPS1; RNA-binding protein with serine-rich domain 1" }, { "name":"107499933 SRRM1; serine\/arginine repetitive matrix protein 1 isoform X1\tK13171 SRRM1; serine\/arginine repetitive matrix protein 1" } ] }, { "name":"TREX complex", "children":[ { "name":"107520582 THOC1; THO complex subunit 1 isoform X1\tK12878 THOC1; THO complex subunit 1" }, { "name":"107497748 THOC2; THO complex subunit 2 isoform X1\tK12879 THOC2; THO complex subunit 2" }, { "name":"107515940 THOC3; THO complex subunit 3\tK12880 THOC3; THO complex subunit 3" }, { "name":"107520286 ALYREF; THO complex subunit 4\tK12881 THOC4; THO complex subunit 4" }, { "name":"107520483 THOC5; THO complex subunit 5 homolog isoform X1\tK13174 THOC5; THO complex subunit 5" }, { "name":"107498773 THOC6; THO complex subunit 6 homolog isoform X2\tK13175 THOC6; THO complex subunit 6" }, { "name":"107513472 THOC7; THO complex subunit 7 homolog\tK13176 THOC7; THO complex subunit 7" }, { "name":"107509053 chromatin target of PRMT1 protein isoform X1\tK28424 CHTOP; chromatin target of PRMT1 protein" } ] }, { "name":"TREX-2 complex", "children":[ { "name":"107514337 PCID2; PCI domain-containing protein 2 isoform X3\tK23801 PCID2; nuclear mRNA export protein PCID2\/THP1" }, { "name":"107504477 SEM1; 26S proteasome complex subunit SEM1\tK10881 SHFM1; 26 proteasome complex subunit DSS1" }, { "name":"107517836 ENY2; transcription and mRNA export factor ENY2 isoform X1\tK11368 ENY2; enhancer of yellow 2 transcription factor" }, { "name":"107520597 CETN2; centrin-2\tK10840 CETN2; centrin-2" }, { "name":"107510993 CETN3; centrin-3 isoform X2\tK16466 CETN3; centrin-3" }, { "name":"107510226 germinal-center associated nuclear protein\tK24317 MCM3AP; germinal-center associated nuclear protein [EC:2.3.1.48]" } ] }, { "name":"Nuclear pore complex", "children":[ { "name":"107521613 TPR; nucleoprotein TPR isoform X1\tK09291 TPR; nucleoprotein TPR" }, { "name":"107500089 RAE1; mRNA export factor\tK14298 RAE1; mRNA export factor" }, { "name":"107498352 SEC13; protein SEC13 homolog isoform X1\tK14004 SEC13; protein transport protein SEC13" }, { "name":"107501178 NUP37; nucleoporin Nup37\tK14302 NUP37; nuclear pore complex protein Nup37" }, { "name":"107503775 NUP85; nuclear pore complex protein Nup85 isoform X1\tK14304 NUP85; nuclear pore complex protein Nup85" }, { "name":"107518461 NUP43; nucleoporin Nup43\tK14305 NUP43; nuclear pore complex protein Nup43" }, { "name":"107505526 NUP50; nuclear pore complex protein Nup50 isoform X1\tK14295 NUP50; nuclear pore complex protein Nup50" }, { "name":"107516363 NUP54; nucleoporin p54 isoform X1\tK14308 NUP54; nuclear pore complex protein Nup54" }, { "name":"107498601 NUP62CL; nucleoporin-62 C-terminal-like protein\tK14306 NUP62; nuclear pore complex protein Nup62" }, { "name":"107500429 NUP62; nuclear pore glycoprotein p62\tK14306 NUP62; nuclear pore complex protein Nup62" }, { "name":"107509448 NUP88; nuclear pore complex protein Nup88 isoform X1\tK14318 NUP88; nuclear pore complex protein Nup88" }, { "name":"107499657 NUP93; nuclear pore complex protein Nup93 isoform X1\tK14309 NUP93; nuclear pore complex protein Nup93" }, { "name":"107517364 NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1\tK14297 NUP98; nuclear pore complex protein Nup98-Nup96" }, { "name":"107512677 NUP107; nuclear pore complex protein Nup107\tK14301 NUP107; nuclear pore complex protein Nup107" }, { "name":"107520058 NUP133; nuclear pore complex protein Nup133\tK14300 NUP133; nuclear pore complex protein Nup133" }, { "name":"107504522 NUP188; nucleoporin NUP188 homolog isoform X1\tK14311 NUP188; nuclear pore complex protein Nup188" }, { "name":"107516274 NUP153; nuclear pore complex protein Nup153 isoform X1\tK14296 NUP153; nuclear pore complex protein Nup153" }, { "name":"107509718 NUP155; nuclear pore complex protein Nup155\tK14312 NUP155; nuclear pore complex protein Nup155" }, { "name":"107511827 NUP160; nuclear pore complex protein Nup160\tK14303 NUP160; nuclear pore complex protein Nup160" }, { "name":"107513281 NUP35; nucleoporin NUP35 isoform X1\tK14313 NUP35; nuclear pore complex protein Nup53" }, { "name":"107498236 NUP205; nuclear pore complex protein Nup205 isoform X2\tK14310 NUP205; nuclear pore complex protein Nup205" }, { "name":"107505419 NUP210; nuclear pore membrane glycoprotein 210 isoform X1\tK14314 NUP210; nuclear pore complex protein Nup210" }, { "name":"107509173 NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1\tK14314 NUP210; nuclear pore complex protein Nup210" }, { "name":"107504554 NUP214; nuclear pore complex protein Nup214 isoform X1\tK14317 NUP214; nuclear pore complex protein Nup214" }, { "name":"107504644 POM121L2; POM121-like protein 2\tK14316 POM121; nuclear pore complex protein Nup121" }, { "name":"107511807 nuclear envelope pore membrane protein POM 121C\tK14316 POM121; nuclear pore complex protein Nup121" }, { "name":"107521742 LOW QUALITY PROTEIN: nuclear envelope pore membrane protein POM 121C-like\tK14316 POM121; nuclear pore complex protein Nup121" }, { "name":"107520894 NUP58; nucleoporin p58\/p45 isoform X1\tK14307 NUPL1; nucleoporin p58\/p45" }, { "name":"107518147 NUP42; nucleoporin NUP42\tK14321 NUPL2; nucleoporin-like protein 2" }, { "name":"107497948 NDC1; nucleoporin NDC1 isoform X1\tK14315 NDC1; nucleoporin NDC1" }, { "name":"107497711 SEH1L; nucleoporin SEH1 isoform X1\tK14299 SEH1; nucleoporin SEH1" }, { "name":"107519863 RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1\tK12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]" }, { "name":"107518252 SENP2; sentrin-specific protease 2 isoform X1\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"107509852 AAAS; aladin isoform X2\tK14320 AAAS; aladin" }, { "name":"107510993 CETN3; centrin-3 isoform X2\tK16466 CETN3; centrin-3" }, { "name":"107500796 GLE1; nucleoporin GLE1 isoform X1\tK18723 GLE1; nucleoporin GLE1" }, { "name":"107501584 NXF1; nuclear RNA export factor 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"107506262 LOW QUALITY PROTEIN: nuclear RNA export factor 2-like\tK14284 NXF; nuclear RNA export factor" }, { "name":"107519684 NXF3; nuclear RNA export factor 3 isoform X3\tK14284 NXF; nuclear RNA export factor" }, { "name":"118607736 nuclear RNA export factor 2-like\tK14284 NXF; nuclear RNA export factor" }, { "name":"107498637 NXT1; NTF2-related export protein 1\tK14285 NXT1_2; NTF2-related export protein 1\/2" }, { "name":"107519301 NXT2; NTF2-related export protein 2 isoform X3\tK14285 NXT1_2; NTF2-related export protein 1\/2" } ] }, { "name":"Ran-mediated transport factors", "children":[ { "name":"107511541 RAN; GTP-binding nuclear protein Ran\tK07936 RAN; GTP-binding nuclear protein Ran" }, { "name":"118605242 LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran-like\tK07936 RAN; GTP-binding nuclear protein Ran" }, { "name":"107511422 ANP32A; acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1\tK18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A\/C\/D" }, { "name":"107511687 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B\tK18647 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B" }, { "name":"107506405 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1\tK05475 TNFSF13; tumor necrosis factor ligand superfamily member 13" }, { "name":"107519915 ELAVL1; ELAV-like protein 1\tK13088 ELAVL1; ELAV-like protein 1" }, { "name":"107497951 ELAVL4; ELAV-like protein 4 isoform X1\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"107515052 ELAVL3; ELAV-like protein 3 isoform X1\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"107516188 ELAVL2; ELAV-like protein 2 isoform X1\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"107517501 FAF2; FAS-associated factor 2\tK18726 FAF2; FAS-associated factor 2" }, { "name":"107502827 transitional endoplasmic reticulum ATPase\tK13525 VCP; transitional endoplasmic reticulum ATPase" }, { "name":"107511437 VCPKMT; protein-lysine methyltransferase METTL21D isoform X1\tK21806 VCPKMT; protein N-lysine methyltransferase METTL21D [EC:2.1.1.-]" }, { "name":"107519401 TNPO2; transportin-2 isoform X1\tK18727 TNPO2; transportin-2" }, { "name":"107502432 XPO1; exportin-1 isoform X1\tK14290 XPO1; exportin-1" }, { "name":"107509243 XPO7; exportin-7 isoform X1\tK18460 XPO7; exportin-7" }, { "name":"107511018 RANBP17; ran-binding protein 17 isoform X1\tK24115 RANBP17; Ran-binding protein 17" }, { "name":"118613802 RANGAP1; ran GTPase-activating protein 1\tK14319 RANGAP1; Ran GTPase-activating protein 1" }, { "name":"107499350 TAF15; TATA-binding protein-associated factor 2N\tK14651 TAF15; transcription initiation factor TFIID subunit 15" }, { "name":"107520379 NUTF2; nuclear transport factor 2\tK28773 NUTF2; nuclear transport factor 2" } ] }, { "name":"eIF4F and regulatory proteins", "children":[ { "name":"107504414 EIF4E; eukaryotic translation initiation factor 4E isoform X2\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"107504992 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"107517568 EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"107505887 EIF4A2; eukaryotic initiation factor 4A-II\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"107506398 EIF4A1; eukaryotic initiation factor 4A-I\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"107504912 EIF4G1; eukaryotic translation initiation factor 4 gamma 1 isoform X1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"107512124 EIF4G2; eukaryotic translation initiation factor 4 gamma 2 isoform X1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"107513047 EIF4G3; eukaryotic translation initiation factor 4 gamma 3 isoform X1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"107509840 EIF4B; eukaryotic translation initiation factor 4B isoform X1\tK03258 EIF4B; translation initiation factor 4B" }, { "name":"107502825 EIF4H; eukaryotic translation initiation factor 4H isoform X1\tK24086 EIF4H; translation initiation factor 4H" }, { "name":"107515968 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1\tK07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1" }, { "name":"107498218 EIF4EBP2; eukaryotic translation initiation factor 4E-binding protein 2\tK18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2" }, { "name":"107521546 EIF4EBP3; eukaryotic translation initiation factor 4E-binding protein 3\tK18645 EIF4EBP3; eukaryotic translation initiation factor 4E binding protein 3" }, { "name":"107502388 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter isoform X1\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter" }, { "name":"107516677 ANGEL1; protein angel homolog 1 isoform X1\tK18729 ANGEL; protein angel" }, { "name":"107521630 ANGEL2; protein angel homolog 2 isoform X1\tK18729 ANGEL; protein angel" }, { "name":"107506403 FXR2; fragile X mental retardation syndrome-related protein 2 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107507030 FXR1; fragile X mental retardation syndrome-related protein 1 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107520736 FMR1; synaptic functional regulator FMR1 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107505088 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"107521885 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"107521914 GEMIN5; gem-associated protein 5 isoform X1\tK13133 GEMIN5; gem associated protein 5" }, { "name":"107518019 TACC3; transforming acidic coiled-coil-containing protein 3 isoform X3\tK14283 TACC3; transforming acidic coiled-coil-containing protein 3" }, { "name":"107505337 CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107507335 CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107511045 CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107514004 CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107502043 ATP-dependent RNA helicase DDX3X-like isoform X1\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"107516648 DDX3X; ATP-dependent RNA helicase DDX3X isoform X1\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"107500008 GIGYF1; GRB10-interacting GYF protein 1 isoform X1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"107504994 GIGYF2; GRB10-interacting GYF protein 2 isoform X1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"107508063 polyadenylate-binding protein 1-like 2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107508336 PABPC4; polyadenylate-binding protein 4 isoform X6\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107508379 polyadenylate-binding protein 1-like 2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107511902 PABPC5; polyadenylate-binding protein 5\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107512230 PABPC1; polyadenylate-binding protein 1 isoform X2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107514563 PABPC1L; polyadenylate-binding protein 1-like isoform X3\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107516244 PABPC4L; polyadenylate-binding protein 4-like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107518967 PAIP1; polyadenylate-binding protein-interacting protein 1 isoform X1\tK14322 PAIP1; polyadenylate-binding protein-interacting protein 1" }, { "name":"107506230 PAIP2; polyadenylate-binding protein-interacting protein 2\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2" }, { "name":"107516204 PAIP2B; polyadenylate-binding protein-interacting protein 2B\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2" }, { "name":"107498436 SKIV2L; helicase SKI2W isoform X1\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]" }, { "name":"107507153 DEAF1; deformed epidermal autoregulatory factor 1 homolog isoform X1\tK23041 DEAF1; deformed epidermal autoregulatory factor 1" }, { "name":"107501635 malignant T-cell-amplified sequence 1\tK07575 MCTS; malignant T-cell-amplified sequence" }, { "name":"107515219 DENR; density-regulated protein\tK24272 DENR; density-regulated protein" } ] }, { "name":"APOBEC1-ACF complex", "children":[ { "name":"107501654 APOBEC1; C->U-editing enzyme APOBEC-1\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"107515496 A1CF; APOBEC1 complementation factor isoform X1\tK24978 A1CF; APOBEC1 complementation factor" } ] }, { "name":"Other transport factors", "children":[ { "name":"107521252 PYM1; partner of Y14 and mago isoform X1\tK14294 WIBG; partner of Y14 and mago" }, { "name":"107508350 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"107514670 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"107521075 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"107500915 DAZAP1; DAZ-associated protein 1 isoform X1\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"107501261 MSI1; RNA-binding protein Musashi homolog 1 isoform X1\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"107503026 MSI2; RNA-binding protein Musashi homolog 2 isoform X1\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"107516176 HBS1L; HBS1-like protein isoform X1\tK14416 HBS1; elongation factor 1 alpha-like protein" }, { "name":"107509663 PELO; protein pelota homolog\tK06965 PELO; protein pelota" }, { "name":"107497982 PABPN1; polyadenylate-binding protein 2 isoform X1\tK14396 PABPN1; polyadenylate-binding protein 2" }, { "name":"107502356 PABPN1L; embryonic polyadenylate-binding protein 2\tK14396 PABPN1; polyadenylate-binding protein 2" }, { "name":"107520522 DDX19A; ATP-dependent RNA helicase DDX19A\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]" }, { "name":"107520524 ATP-dependent RNA helicase DDX19B isoform X2\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]" }, { "name":"107498951 DDX25; ATP-dependent RNA helicase DDX25 isoform X1\tK18656 DDX25; ATP-dependent RNA helicase DDX25 [EC:5.6.2.7]" }, { "name":"107519922 XAB2; pre-mRNA-splicing factor SYF1\tK12867 SYF1; pre-mRNA-splicing factor SYF1" }, { "name":"107521244 SAP domain-containing ribonucleoprotein isoform X1\tK18732 SARNP; SAP domain-containing ribonucleoprotein" }, { "name":"107503587 RCC1; regulator of chromosome condensation isoform X1\tK11493 RCC1; regulator of chromosome condensation" }, { "name":"107501095 LARP6; la-related protein 6\tK18733 LARP6; la-related protein 6" }, { "name":"107521570 PURA; transcriptional activator protein Pur-alpha\tK21772 PURA; transcriptional activator protein Pur-alpha" }, { "name":"107512398 PURB; transcriptional activator protein Pur-beta\tK21799 PURB; transcriptional activator protein Pur-beta" }, { "name":"107505558 POLDIP3; polymerase delta-interacting protein 3 isoform X1\tK22414 POLDIP3; polymerase delta-interacting protein 3" }, { "name":"107508166 ZC3H11A; zinc finger CCCH domain-containing protein 11A\tK22415 ZC3H11; zinc finger CCCH domain-containing protein 11" }, { "name":"118611431 LENG8; leukocyte receptor cluster member 8 isoform X1\tK23802 LENG8; SAC3 family protein LENG8\/THP3" }, { "name":"107505835 PATL2; protein PAT1 homolog 2\tK24823 PATL2; protein PAT1 homolog 2" }, { "name":"107505255 FYTTD1; UAP56-interacting factor\tK28772 FYTTD1; UAP56-interacting factor" } ] } ] }, { "name":"Surveillance factors", "children":[ { "name":"Surveillance complex", "children":[ { "name":"107518708 ETF1; eukaryotic peptide chain release factor subunit 1 isoform X1\tK03265 ETF1; peptide chain release factor subunit 1" }, { "name":"107509128 GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B\tK03267 ERF3; peptide chain release factor subunit 3" }, { "name":"107516798 GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1\tK03267 ERF3; peptide chain release factor subunit 3" }, { "name":"107503721 UPF1; regulator of nonsense transcripts 1 isoform X1\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"107504852 UPF2; regulator of nonsense transcripts 2 isoform X1\tK14327 UPF2; regulator of nonsense transcripts 2" }, { "name":"107506657 UPF3B; regulator of nonsense transcripts 3B isoform X1\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"107514355 UPF3A; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A\tK14328 UPF3; regulator of nonsense transcripts 3" } ] }, { "name":"Protein phosphatase 2A", "children":[ { "name":"107505807 PPP2CB; serine\/threonine-protein phosphatase 2A catalytic subunit beta isoform\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]" }, { "name":"107506800 PPP2CA; serine\/threonine-protein phosphatase 2A catalytic subunit alpha isoform\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]" }, { "name":"107500417 PPP2R1A; serine\/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A" }, { "name":"107521184 PPP2R1B; serine\/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A" }, { "name":"107500870 PPP2R2B; serine\/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"107515450 PPP2R2A; serine\/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"107519027 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"107505863 PPP2R3B; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"107508495 PPP2R3A; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"107514412 PPP2R3C; serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"107501966 PPP2R5D; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"107509328 PPP2R5E; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"107517041 PPP2R5B; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"107521366 PPP2R5C; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"107521621 PPP2R5A; serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" } ] }, { "name":"Other surveillance factors", "children":[ { "name":"107516811 SMG1; serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"107521495 SMG5; protein SMG5 isoform X1\tK11125 SMG5; protein SMG5" }, { "name":"107507701 SMG6; telomerase-binding protein EST1A isoform X1\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]" }, { "name":"107511294 SMG7; protein SMG7 isoform X1\tK14409 SMG7; protein SMG7" }, { "name":"107499176 SMG8; protein SMG8\tK18734 SMG8; protein SMG8" }, { "name":"107512307 SMG9; protein SMG9 isoform X1\tK18735 SMG9; protein SMG9" }, { "name":"107500008 GIGYF1; GRB10-interacting GYF protein 1 isoform X1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"107504994 GIGYF2; GRB10-interacting GYF protein 2 isoform X1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"107499081 SECISBP2; selenocysteine insertion sequence-binding protein 2 isoform X1\tK19539 SECISBP2; selenocysteine insertion sequence-binding protein 2" }, { "name":"107506552 SECISBP2L; selenocysteine insertion sequence-binding protein 2-like isoform X1\tK19539 SECISBP2; selenocysteine insertion sequence-binding protein 2" }, { "name":"107516016 DHX34; probable ATP-dependent RNA helicase DHX34\tK20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6]" }, { "name":"107519211 GTPBP1; GTP-binding protein 1 isoform X1\tK24887 GTPBP1; GTP-binding protein 1" } ] } ] }, { "name":"Factors involved in mRNA localization", "children":[ { "name":"Cargo complex", "children":[ { "name":"107507282 PUM3; pumilio homolog 3 isoform X2\tK14844 PUF6; pumilio homology domain family member 6" }, { "name":"107515157 MYO5A; unconventional myosin-Va isoform X1\tK10357 MYO5; myosin V" }, { "name":"107519726 MYO5C; unconventional myosin-Vc isoform X1\tK10357 MYO5; myosin V" }, { "name":"107520740 MYO5B; unconventional myosin-Vb isoform X1\tK10357 MYO5; myosin V" }, { "name":"107503285 BICD1; protein bicaudal D homolog 1 isoform X2\tK18739 BICD; protein bicaudal D" }, { "name":"107519005 BICD2; protein bicaudal D homolog 2 isoform X1\tK18739 BICD; protein bicaudal D" }, { "name":"107514492 EXD1; piRNA biogenesis protein EXD1 isoform X1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1" } ] }, { "name":"Factors that have mRNA localization signals", "children":[ { "name":"107515934 ACTB; actin, cytoplasmic 1\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"107520262 ACTG1; actin, cytoplasmic 2\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"107498651 myelin basic protein isoform X1\tK17269 MBP; myelin basic protein" }, { "name":"107513674 VIM; vimentin\tK07606 VIM; vimentin" }, { "name":"107499671 metallothionein-2A\tK14739 MT1_2; metallothionein 1\/2" }, { "name":"107506202 MYC; myc proto-oncogene protein\tK04377 MYC; Myc proto-oncogene protein" }, { "name":"107503722 GDF1; embryonic growth\/differentiation factor 1\tK05495 GDF1; growth differentiation factor 1" }, { "name":"107515838 TBX6; T-box transcription factor TBX6 isoform X1\tK10180 TBX6; T-box protein 6" }, { "name":"107509751 NANOS1; nanos homolog 1\tK18741 NANOS1; protein nanos 1" } ] }, { "name":"Trans-acting binding proteins", "children":[ { "name":"107504548 FUBP3; far upstream element-binding protein 3 isoform X1\tK13210 FUBP; far upstream element-binding protein" }, { "name":"107511112 far upstream element-binding protein 2 isoform X2\tK13210 FUBP; far upstream element-binding protein" }, { "name":"107513891 FUBP1; far upstream element-binding protein 1 isoform X1\tK13210 FUBP; far upstream element-binding protein" }, { "name":"107501007 LOW QUALITY PROTEIN: elongation factor 1-alpha, somatic form-like\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"107502333 LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"107505781 EEF1A2; elongation factor 1-alpha 2\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"107509282 EEF1A1; elongation factor 1-alpha 1\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"107513406 LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"107501569 EEF1G; elongation factor 1-gamma\tK03233 EEF1G; elongation factor 1-gamma" }, { "name":"107505661 HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2\/B1 isoform X1\tK13158 HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2\/B1" }, { "name":"107509344 HAX1; HCLS1-associated protein X-1 isoform X1\tK16220 HAX1; HCLS1-associated protein X-1" }, { "name":"107497244 AGFG1; arf-GAP domain and FG repeat-containing protein 1 isoform X1\tK15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1" }, { "name":"107510322 STAU1; double-stranded RNA-binding protein Staufen homolog 1 isoform X1\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"107515181 STAU2; double-stranded RNA-binding protein Staufen homolog 2 isoform X2\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"107518143 IGF2BP3; insulin-like growth factor 2 mRNA-binding protein 3 isoform X1\tK13197 IGF2BP3; insulin-like growth factor 2 mRNA-binding protein 3" }, { "name":"107500929 PTBP1; polypyrimidine tract-binding protein 1 isoform X2\tK13218 PTBP1; polypyrimidine tract-binding protein 1" }, { "name":"107505337 CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107507335 CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107511045 CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107514004 CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" } ] }, { "name":"Other mRNA localization factors", "children":[ { "name":"107506403 FXR2; fragile X mental retardation syndrome-related protein 2 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107507030 FXR1; fragile X mental retardation syndrome-related protein 1 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107520736 FMR1; synaptic functional regulator FMR1 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107505088 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"107521885 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"107509859 PCBP2; poly(rC)-binding protein 2 isoform X10\tK13162 PCBP2; poly(rC)-binding protein 2" }, { "name":"107504169 PCBP4; poly(rC)-binding protein 4 isoform X2\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4" }, { "name":"107510220 PCBP3; poly(rC)-binding protein 3 isoform X1\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4" }, { "name":"107512027 CAPRIN1; caprin-1\tK18743 CAPRIN1; caprin-1" }, { "name":"107514395 CAPRIN2; caprin-2 isoform X1\tK18744 CAPRIN2; caprin-2" }, { "name":"107508294 YBX1; Y-box-binding protein 1 isoform X1\tK09276 YBX1; Y-box-binding protein 1" } ] } ] }, { "name":"mRNA cycle factors", "children":[ { "name":"Common to processing body (P body) and stress granule", "children":[ { "name":"107502406 XRN1; 5'-3' exoribonuclease 1 isoform X1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]" }, { "name":"107504409 AGO2; protein argonaute-2 isoform X1\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"107512084 AGO3; protein argonaute-3 isoform X1\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"107512086 AGO1; protein argonaute-1 isoform X1\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"107512087 AGO4; protein argonaute-4\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"107504414 EIF4E; eukaryotic translation initiation factor 4E isoform X2\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"107504992 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"107517568 EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"107503721 UPF1; regulator of nonsense transcripts 1 isoform X1\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"107502043 ATP-dependent RNA helicase DDX3X-like isoform X1\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"107516648 DDX3X; ATP-dependent RNA helicase DDX3X isoform X1\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"107507913 DDX6; probable ATP-dependent RNA helicase DDX6\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]" }, { "name":"107500950 MEX3D; RNA-binding protein MEX3D\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"107505320 MEX3B; RNA-binding protein MEX3B isoform X1\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"107512855 MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"107521534 MEX3A; RNA-binding protein MEX3A\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"107520316 FASTK; fas-activated serine\/threonine kinase isoform X2\tK08290 FASTK; Fas-activated serine\/threonine kinase [EC:2.7.11.8]" }, { "name":"107503667 LSM14B; protein LSM14 homolog B isoform X1\tK18749 LSM14; protein LSM14" }, { "name":"107521409 LSM14A; protein LSM14 homolog A isoform X1\tK18749 LSM14; protein LSM14" }, { "name":"107497739 LOW QUALITY PROTEIN: poly(rC)-binding protein 1-like\tK12889 PCBP1; poly(rC)-binding protein 1" }, { "name":"107519096 PCBP1; poly(rC)-binding protein 1\tK12889 PCBP1; poly(rC)-binding protein 1" }, { "name":"107509859 PCBP2; poly(rC)-binding protein 2 isoform X10\tK13162 PCBP2; poly(rC)-binding protein 2" }, { "name":"107508294 YBX1; Y-box-binding protein 1 isoform X1\tK09276 YBX1; Y-box-binding protein 1" }, { "name":"107498033 AJUBA; LIM domain-containing protein ajuba\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"107509087 LIMD1; LIM domain-containing protein 1 isoform X1\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"107521420 Wilms tumor protein 1-interacting protein isoform X1\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"107501654 APOBEC1; C->U-editing enzyme APOBEC-1\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"107502069 DNA dC->dU-editing enzyme APOBEC-3A\tK18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]" }, { "name":"107519218 DNA dC->dU-editing enzyme APOBEC-3G\tK18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]" }, { "name":"118613791 DNA dC->dU-editing enzyme APOBEC-3F-like isoform X1\tK18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]" }, { "name":"118613792 DNA dC->dU-editing enzyme APOBEC-3C-like isoform X1\tK18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]" }, { "name":"107499799 MOV10; helicase MOV-10 isoform X1\tK18422 MOV10; helicase MOV-10 [EC:5.6.2.5]" }, { "name":"107501027 PNRC2; proline-rich nuclear receptor coactivator 2\tK18751 PNRC2; proline-rich nuclear receptor coactivator 2" }, { "name":"107498698 TNPO1; transportin-1 isoform X1\tK18752 TNPO1; transportin-1" }, { "name":"107516811 SMG1; serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"107521495 SMG5; protein SMG5 isoform X1\tK11125 SMG5; protein SMG5" }, { "name":"107507701 SMG6; telomerase-binding protein EST1A isoform X1\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]" }, { "name":"107511294 SMG7; protein SMG7 isoform X1\tK14409 SMG7; protein SMG7" }, { "name":"107521829 ZFP36; mRNA decay activator protein ZFP36\tK15308 TTP; tristetraprolin" }, { "name":"107503275 ZFP36L1; mRNA decay activator protein ZFP36L1\tK18753 ZFP36L; butyrate response factor" }, { "name":"107509585 ZFP36L2; mRNA decay activator protein ZFP36L2\tK18753 ZFP36L; butyrate response factor" }, { "name":"107500708 LIN28B; protein lin-28 homolog B isoform X2\tK18754 LIN28; protein lin-28" }, { "name":"107503526 LIN28A; protein lin-28 homolog A\tK18754 LIN28; protein lin-28" }, { "name":"107517979 HTT; huntingtin isoform X1\tK04533 HD; huntingtin" }, { "name":"107514396 IPO8; importin-8\tK18755 IPO8; importin-8" }, { "name":"107501460 BICC1; protein bicaudal C homolog 1 isoform X3\tK18756 BICC1; protein bicaudal C" }, { "name":"107508350 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"107514670 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"107521075 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"107511590 PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"107519437 PRKACA; cAMP-dependent protein kinase catalytic subunit alpha\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"107512494 LARP1B; la-related protein 1B isoform X1\tK18757 LARP1; la-related protein 1" }, { "name":"107521880 LARP1; la-related protein 1 isoform X1\tK18757 LARP1; la-related protein 1" }, { "name":"107513252 ATXN2; ataxin-2 isoform X9\tK23625 ATXN2; ataxin-2" }, { "name":"107515800 ATXN2L; ataxin-2-like protein isoform X5\tK23625 ATXN2; ataxin-2" } ] }, { "name":"P-body specific factors", "children":[ { "name":"107512107 DCP2; m7GpppN-mRNA hydrolase isoform X1\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]" }, { "name":"107516538 DCP1A; mRNA-decapping enzyme 1A\tK12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]" }, { "name":"107500693 DCP1B; mRNA-decapping enzyme 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]" }, { "name":"107515967 LSM1; U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1" }, { "name":"107498478 LSM2; U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2" }, { "name":"107509406 LSM3; U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"118612442 LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"107503753 LSM4; U6 snRNA-associated Sm-like protein LSm4\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4" }, { "name":"107518524 LSM5; U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5" }, { "name":"107520352 LSM6; U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6" }, { "name":"107520086 LSM7; U6 snRNA-associated Sm-like protein LSm7\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7" }, { "name":"107519977 LSM8; LSM8 homolog, U6 small nuclear RNA associated\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8" }, { "name":"107497533 KLC2; kinesin light chain 2\tK10407 KLC; kinesin light chain" }, { "name":"107498378 KLC1; kinesin light chain 1 isoform X1\tK10407 KLC; kinesin light chain" }, { "name":"107501964 KLC4; kinesin light chain 4 isoform X1\tK10407 KLC; kinesin light chain" }, { "name":"107513627 KLC3; kinesin light chain 3\tK10407 KLC; kinesin light chain" }, { "name":"107515157 MYO5A; unconventional myosin-Va isoform X1\tK10357 MYO5; myosin V" }, { "name":"107519726 MYO5C; unconventional myosin-Vc isoform X1\tK10357 MYO5; myosin V" }, { "name":"107520740 MYO5B; unconventional myosin-Vb isoform X1\tK10357 MYO5; myosin V" }, { "name":"107497847 tubulin alpha-3 chain\tK07374 TUBA; tubulin alpha" }, { "name":"107497857 tubulin alpha-3 chain-like\tK07374 TUBA; tubulin alpha" }, { "name":"107500328 TUBA8; tubulin alpha-8 chain isoform X1\tK07374 TUBA; tubulin alpha" }, { "name":"107514241 tubulin alpha-1B chain\tK07374 TUBA; tubulin alpha" }, { "name":"107514242 tubulin alpha-1A chain\tK07374 TUBA; tubulin alpha" }, { "name":"107514243 tubulin alpha-1C chain\tK07374 TUBA; tubulin alpha" }, { "name":"107516732 tubulin alpha-4A chain isoform X1\tK07374 TUBA; tubulin alpha" }, { "name":"107516782 tubulin alpha-1B chain\tK07374 TUBA; tubulin alpha" }, { "name":"107505337 CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107507335 CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107511045 CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107514004 CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"107521914 GEMIN5; gem-associated protein 5 isoform X1\tK13133 GEMIN5; gem associated protein 5" }, { "name":"107518019 TACC3; transforming acidic coiled-coil-containing protein 3 isoform X3\tK14283 TACC3; transforming acidic coiled-coil-containing protein 3" }, { "name":"107500811 TNRC6B; trinucleotide repeat-containing gene 6B protein isoform X1\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"107508811 TNRC6A; trinucleotide repeat-containing gene 6A protein\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"107510055 TNRC6C; trinucleotide repeat-containing gene 6C protein isoform X1\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"107516341 CNOT1; CCR4-NOT transcription complex subunit 1 isoform X4\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1" }, { "name":"107514512 CNOT2; CCR4-NOT transcription complex subunit 2 isoform X2\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2" }, { "name":"107503039 CNOT3; CCR4-NOT transcription complex subunit 3 isoform X1\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3" }, { "name":"107498230 CNOT4; CCR4-NOT transcription complex subunit 4 isoform X1\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]" }, { "name":"107512331 CNOT6; CCR4-NOT transcription complex subunit 6 isoform X1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"107515522 CNOT6L; CCR4-NOT transcription complex subunit 6-like isoform X1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"107502560 CNOT7; CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"107521916 CNOT8; CCR4-NOT transcription complex subunit 8\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"107521407 GARRE1; granule associated Rac and RHOG effector protein 1\tK26671 GARRE1; granule associated Rac and RHOG effector protein 1" }, { "name":"107504990 DIS3L2; DIS3-like exonuclease 2 isoform X1\tK18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]" }, { "name":"107521229 PAN2; PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]" }, { "name":"107514323 PAN3; PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3" }, { "name":"107504502 TOB1; protein Tob1\tK14443 TOB; protein Tob\/BTG" }, { "name":"107505587 TOB2; protein Tob2\tK14443 TOB; protein Tob\/BTG" }, { "name":"107508130 BTG2; protein BTG2\tK14443 TOB; protein Tob\/BTG" }, { "name":"107512690 BTG3; protein BTG3\tK14443 TOB; protein Tob\/BTG" }, { "name":"107518653 BTG1; protein BTG1\tK14443 TOB; protein Tob\/BTG" }, { "name":"107521181 BTG4; protein BTG4\tK14443 TOB; protein Tob\/BTG" }, { "name":"107502388 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter isoform X1\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter" }, { "name":"107497338 PATL1; protein PAT1 homolog 1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1" }, { "name":"107510536 EDC3; enhancer of mRNA-decapping protein 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3" }, { "name":"107520387 EDC4; enhancer of mRNA-decapping protein 4 isoform X3\tK12616 EDC4; enhancer of mRNA-decapping protein 4" }, { "name":"107515984 NANOS2; nanos homolog 2\tK18760 NANOS2; protein nanos 2" }, { "name":"107519389 NANOS3; nanos homolog 3 isoform X1\tK18761 NANOS3; protein nanos 3" }, { "name":"107504852 UPF2; regulator of nonsense transcripts 2 isoform X1\tK14327 UPF2; regulator of nonsense transcripts 2" }, { "name":"107506657 UPF3B; regulator of nonsense transcripts 3B isoform X1\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"107514355 UPF3A; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"107517372 TRIM21; E3 ubiquitin-protein ligase TRIM21\tK10651 TRIM21; tripartite motif-containing protein 21 [EC:2.3.2.27]" }, { "name":"107508779 TRIM71; E3 ubiquitin-protein ligase TRIM71\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]" }, { "name":"107501562 POLR2G; DNA-directed RNA polymerase II subunit RPB7\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7" }, { "name":"107519635 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase\tK16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]" }, { "name":"107501715 ZAR1; zygote arrest protein 1\tK18762 ZAR1; zygote arrest protein 1" }, { "name":"107504797 ZAR1L; ZAR1-like protein isoform X1\tK18762 ZAR1; zygote arrest protein 1" }, { "name":"107503542 YTHDF2; YTH domain-containing family protein 2 isoform X1\tK20102 YTHDF; YTH domain-containing family protein" }, { "name":"107505777 YTHDF1; YTH domain-containing family protein 1 isoform X1\tK20102 YTHDF; YTH domain-containing family protein" }, { "name":"107521314 YTHDF3; YTH domain-containing family protein 3 isoform X3\tK20102 YTHDF; YTH domain-containing family protein" } ] }, { "name":"Stress granule specific factors", "children":[ { "name":"107509761 TIAL1; nucleolysin TIAR isoform X1\tK13201 TIA1; nucleolysin TIA-1\/TIAR" }, { "name":"107519105 TIA1; nucleolysin TIA-1 isoform X1\tK13201 TIA1; nucleolysin TIA-1\/TIAR" }, { "name":"107508063 polyadenylate-binding protein 1-like 2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107508336 PABPC4; polyadenylate-binding protein 4 isoform X6\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107508379 polyadenylate-binding protein 1-like 2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107511902 PABPC5; polyadenylate-binding protein 5\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107512230 PABPC1; polyadenylate-binding protein 1 isoform X2\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107514563 PABPC1L; polyadenylate-binding protein 1-like isoform X3\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107516244 PABPC4L; polyadenylate-binding protein 4-like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"107510322 STAU1; double-stranded RNA-binding protein Staufen homolog 1 isoform X1\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"107515181 STAU2; double-stranded RNA-binding protein Staufen homolog 2 isoform X2\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"107506403 FXR2; fragile X mental retardation syndrome-related protein 2 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107507030 FXR1; fragile X mental retardation syndrome-related protein 1 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107520736 FMR1; synaptic functional regulator FMR1 isoform X1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"107519915 ELAVL1; ELAV-like protein 1\tK13088 ELAVL1; ELAV-like protein 1" }, { "name":"107520500 G3BP1; ras GTPase-activating protein-binding protein 1 isoform X1\tK17265 G3BP1; Ras GTPase-activating protein-binding protein 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"107515328 G3BP2; ras GTPase-activating protein-binding protein 2 isoform X1\tK24983 G3BP2; Ras GTPase-activating protein-binding protein 2" }, { "name":"107516601 EIF2A; eukaryotic translation initiation factor 2A isoform X2\tK15026 EIF2A; translation initiation factor 2A" }, { "name":"107497387 EIF3B; eukaryotic translation initiation factor 3 subunit B\tK03253 EIF3B; translation initiation factor 3 subunit B" }, { "name":"107505887 EIF4A2; eukaryotic initiation factor 4A-II\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"107506398 EIF4A1; eukaryotic initiation factor 4A-I\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"107510084 EIF4A3; eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"107509840 EIF4B; eukaryotic translation initiation factor 4B isoform X1\tK03258 EIF4B; translation initiation factor 4B" }, { "name":"107504912 EIF4G1; eukaryotic translation initiation factor 4 gamma 1 isoform X1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"107512124 EIF4G2; eukaryotic translation initiation factor 4 gamma 2 isoform X1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"107513047 EIF4G3; eukaryotic translation initiation factor 4 gamma 3 isoform X1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"107500168 RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X5\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"107501695 RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X3\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"107503561 RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"107519754 RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"107517551 RACK1; receptor of activated protein C kinase 1\tK14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein" }, { "name":"107503081 TRAF2; TNF receptor-associated factor 2 isoform X3\tK03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]" }, { "name":"107501584 NXF1; nuclear RNA export factor 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"107506262 LOW QUALITY PROTEIN: nuclear RNA export factor 2-like\tK14284 NXF; nuclear RNA export factor" }, { "name":"107519684 NXF3; nuclear RNA export factor 3 isoform X3\tK14284 NXF; nuclear RNA export factor" }, { "name":"118607736 nuclear RNA export factor 2-like\tK14284 NXF; nuclear RNA export factor" }, { "name":"107515022 HDAC6; histone deacetylase 6 isoform X1\tK11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]" }, { "name":"107514615 TDRD3; tudor domain-containing protein 3 isoform X1\tK18404 TDRD3; tudor domain-containing protein 3" }, { "name":"107514268 LARP4; la-related protein 4 isoform X1\tK18763 LARP4; la-related protein 4" }, { "name":"107514291 LARP4B; la-related protein 4B isoform X1\tK18763 LARP4; la-related protein 4" } ] } ] } ] }, { "name":"mRNA degradation factors", "children":[ { "name":"5'-3' decay", "children":[ { "name":"Decapping complex", "children":[ { "name":"107516538 DCP1A; mRNA-decapping enzyme 1A\tK12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]" }, { "name":"107500693 DCP1B; mRNA-decapping enzyme 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]" }, { "name":"107512107 DCP2; m7GpppN-mRNA hydrolase isoform X1\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]" }, { "name":"107507913 DDX6; probable ATP-dependent RNA helicase DDX6\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]" }, { "name":"107510536 EDC3; enhancer of mRNA-decapping protein 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3" }, { "name":"107520387 EDC4; enhancer of mRNA-decapping protein 4 isoform X3\tK12616 EDC4; enhancer of mRNA-decapping protein 4" }, { "name":"107497338 PATL1; protein PAT1 homolog 1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1" } ] }, { "name":"Lsm complex", "children":[ { "name":"107515967 LSM1; U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1" }, { "name":"107498478 LSM2; U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2" }, { "name":"107509406 LSM3; U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"118612442 LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"107503753 LSM4; U6 snRNA-associated Sm-like protein LSm4\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4" }, { "name":"107518524 LSM5; U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5" }, { "name":"107520352 LSM6; U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6" }, { "name":"107520086 LSM7; U6 snRNA-associated Sm-like protein LSm7\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7" }, { "name":"107519977 LSM8; LSM8 homolog, U6 small nuclear RNA associated\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8" } ] }, { "name":"5' exonucleases", "children":[ { "name":"107502406 XRN1; 5'-3' exoribonuclease 1 isoform X1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]" }, { "name":"107500776 XRN2; 5'-3' exoribonuclease 2 isoform X1\tK12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]" }, { "name":"107508467 NUDT16; U8 snoRNA-decapping enzyme\tK16855 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]" } ] }, { "name":"Other 5'-3' decay factors", "children":[ { "name":"107507803 DCPS; m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]" }, { "name":"107502181 HELZ; probable helicase with zinc finger domain isoform X1\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]" } ] } ] }, { "name":"3'-5' decay", "children":[ { "name":"Core exosome factors", "children":[ { "name":"107497050 exosome complex component CSL4-like\tK07573 CSL4; exosome complex component CSL4" }, { "name":"107520422 EXOSC1; exosome complex component CSL4 isoform X1\tK07573 CSL4; exosome complex component CSL4" }, { "name":"107504549 EXOSC2; exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4" }, { "name":"107511671 EXOSC3; exosome complex component RRP40\tK03681 RRP40; exosome complex component RRP40" }, { "name":"107503508 EXOSC4; exosome complex component RRP41\tK11600 RRP41; exosome complex component RRP41" }, { "name":"107505483 EXOSC5; exosome complex component RRP46\tK12590 RRP46; exosome complex component RRP46" }, { "name":"107520525 EXOSC6; exosome complex component MTR3\tK12587 MTR3; exosome complex component MTR3" }, { "name":"107509081 EXOSC7; exosome complex component RRP42 isoform X2\tK12589 RRP42; exosome complex component RRP42" }, { "name":"107503944 EXOSC8; exosome complex component RRP43\tK12586 RRP43; exosome complex component RRP43" }, { "name":"107521164 EXOSC9; exosome complex component RRP45 isoform X1\tK03678 RRP45; exosome complex component RRP45" } ] }, { "name":"Exosome cofactors", "children":[ { "name":"107504282 DIS3; exosome complex exonuclease RRP44 isoform X1\tK12585 DIS3; exosome complex exonuclease DIS3\/RRP44 [EC:3.1.13.-]" }, { "name":"107508944 DIS3L; DIS3-like exonuclease 1 isoform X1\tK18681 DIS3L; DIS3-like exonuclease 1 [EC:3.1.13.-]" }, { "name":"107513110 EXOSC10; exosome component 10 isoform X1\tK12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]" }, { "name":"107506936 C1D; nuclear nucleic acid-binding protein C1D\tK12592 C1D; exosome complex protein LRP1" }, { "name":"107521351 MPHOSPH6; M-phase phosphoprotein 6\tK12593 MPHOSPH6; M-phase phosphoprotein 6, animal type" }, { "name":"107512535 probable ATP-dependent RNA helicase DDX60 isoform X1\tK20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]" }, { "name":"107512537 probable ATP-dependent RNA helicase DDX60 isoform X2\tK20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]" } ] }, { "name":"TRAMP complex", "children":[ { "name":"107512251 TENT4B; terminal nucleotidyltransferase 4B isoform X1\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]" }, { "name":"107518891 TENT4A; terminal nucleotidyltransferase 4A isoform X3\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]" }, { "name":"107511663 ZCCHC7; zinc finger CCHC domain-containing protein 7 isoform X2\tK12597 AIR1_2; protein AIR1\/2" }, { "name":"107509644 MTREX; exosome RNA helicase MTR4\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]" } ] }, { "name":"Ski complex", "children":[ { "name":"107498436 SKIV2L; helicase SKI2W isoform X1\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]" }, { "name":"107518283 TTC37; tetratricopeptide repeat protein 37 isoform X1\tK12600 SKI3; superkiller protein 3" }, { "name":"107500511 WDR61; WD repeat-containing protein 61\tK12602 WDR61; WD repeat-containing protein 61" } ] }, { "name":"Ccr4-NOT complex", "children":[ { "name":"107512331 CNOT6; CCR4-NOT transcription complex subunit 6 isoform X1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"107515522 CNOT6L; CCR4-NOT transcription complex subunit 6-like isoform X1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"107516341 CNOT1; CCR4-NOT transcription complex subunit 1 isoform X4\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1" }, { "name":"107514512 CNOT2; CCR4-NOT transcription complex subunit 2 isoform X2\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2" }, { "name":"107503039 CNOT3; CCR4-NOT transcription complex subunit 3 isoform X1\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3" }, { "name":"107498230 CNOT4; CCR4-NOT transcription complex subunit 4 isoform X1\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]" }, { "name":"107502560 CNOT7; CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"107521916 CNOT8; CCR4-NOT transcription complex subunit 8\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"107516706 CNOT9; CCR4-NOT transcription complex subunit 9 isoform X1\tK12606 RCD1; CCR4-NOT transcription complex subunit 9" }, { "name":"107508780 CNOT10; CCR4-NOT transcription complex subunit 10 isoform X1\tK12607 CNOT10; CCR4-NOT transcription complex subunit 10" } ] }, { "name":"Pan complex", "children":[ { "name":"107521229 PAN2; PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]" }, { "name":"107514323 PAN3; PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3" } ] }, { "name":"Other 3'-5' decay factors", "children":[ { "name":"107502512 PARN; poly(A)-specific ribonuclease PARN isoform X1\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]" }, { "name":"107514732 PNLDC1; poly(A)-specific ribonuclease PNLDC1 isoform X1\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]" }, { "name":"107507596 DHX36; ATP-dependent DNA\/RNA helicase DHX36\tK14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]" }, { "name":"107504502 TOB1; protein Tob1\tK14443 TOB; protein Tob\/BTG" }, { "name":"107505587 TOB2; protein Tob2\tK14443 TOB; protein Tob\/BTG" }, { "name":"107508130 BTG2; protein BTG2\tK14443 TOB; protein Tob\/BTG" }, { "name":"107512690 BTG3; protein BTG3\tK14443 TOB; protein Tob\/BTG" }, { "name":"107518653 BTG1; protein BTG1\tK14443 TOB; protein Tob\/BTG" }, { "name":"107521181 BTG4; protein BTG4\tK14443 TOB; protein Tob\/BTG" }, { "name":"107497048 CSF2; granulocyte-macrophage colony-stimulating factor\tK05427 CSF2; granulocyte-macrophage colony-stimulating factor" }, { "name":"107515347 NOCT; nocturnin isoform X1\tK18764 NOCT; nocturnin [EC:3.1.3.108]" }, { "name":"107504165 ERI1; 3'-5' exoribonuclease 1 isoform X1\tK18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-]" }, { "name":"107516068 ERI2; ERI1 exoribonuclease 2 isoform X1\tK18417 ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-]" }, { "name":"107507803 DCPS; m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]" }, { "name":"107503409 PDE12; 2',5'-phosphodiesterase 12\tK19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]" }, { "name":"107500518 IREB2; iron-responsive element-binding protein 2\tK22416 IREB2; iron-responsive element-binding protein 2" }, { "name":"107502181 HELZ; probable helicase with zinc finger domain isoform X1\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]" }, { "name":"107511877 HELZ2; helicase with zinc finger domain 2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]" }, { "name":"107515462 NRDE2; nuclear exosome regulator NRDE2\tK26109 NRDE2; nuclear exosome regulator NRDE2" }, { "name":"107503954 SAMD4A; protein Smaug homolog 1 isoform X1\tK27396 SMG; protein Smaug" }, { "name":"107521779 SAMD4B; protein Smaug homolog 2 isoform X1\tK27396 SMG; protein Smaug" }, { "name":"107518594 FOCAD; focadhesin isoform X1\tK27498 FOCAD; focadhesin" } ] } ] }, { "name":"Other degradation factors", "children":[ { "name":"RNases", "children":[ { "name":"107521167 RNASE1; ribonuclease pancreatic\tK01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]" }, { "name":"107521168 RNASE2; non-secretory ribonuclease\tK01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]" }, { "name":"107521162 RNASE4; ribonuclease 4\tK16632 RNASE4; ribonuclease 4 [EC:3.1.27.-]" }, { "name":"107521112 RNASE6; ribonuclease K6\tK01172 RNASE6_7_8; ribonuclease 6\/7\/8 [EC:3.1.27.-]" }, { "name":"107521153 ribonuclease 7-like\tK01172 RNASE6_7_8; ribonuclease 6\/7\/8 [EC:3.1.27.-]" }, { "name":"107521134 RNASE11; probable ribonuclease 11\tK16633 RNASE11; ribonuclease 11 [EC:3.1.27.-]" }, { "name":"107498252 ZC3H12C; probable ribonuclease ZC3H12C isoform X1\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"107499326 ZC3H12B; probable ribonuclease ZC3H12B\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"107517066 ZC3H12A; endoribonuclease ZC3H12A\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"107518446 ZC3H12D; probable ribonuclease ZC3H12D isoform X1\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" } ] } ] } ] } ] }, { "name":"Prokaryotic type", "children":[ { "name":"Bacterial mRNA degradation factors", "children":[ { "name":"RNA degradosome components", "children":[ { "name":"Ribonucreases", "children":[ { "name":"107507258 DROSHA; ribonuclease 3 isoform X1\tK03685 rnc; ribonuclease III [EC:3.1.26.3]" }, { "name":"107505070 REXO2; oligoribonuclease, mitochondrial isoform X1\tK13288 orn; oligoribonuclease [EC:3.1.-.-]" } ] }, { "name":"Helicases" }, { "name":"Other RNA degradosome components", "children":[ { "name":"107509478 ENO3; beta-enolase isoform X1\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"107519838 ENO2; gamma-enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"107520165 ENO1; alpha-enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"107519673 PNPT1; polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]" }, { "name":"107499890 PFKM; ATP-dependent 6-phosphofructokinase, muscle type\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" }, { "name":"107510162 PFKL; ATP-dependent 6-phosphofructokinase, liver type\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" }, { "name":"107519463 ATP-dependent 6-phosphofructokinase, platelet type isoform X2\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" } ] } ] }, { "name":"Other RNA degradation factors", "children":[ { "name":"Chaperones", "children":[ { "name":"107518704 HSPA9; stress-70 protein, mitochondrial\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"107503140 HSPD1; 60 kDa heat shock protein, mitochondrial\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" } ] }, { "name":"Others" }, { "name":"Bacterial Small RNA Regulators" } ] } ] }, { "name":"Archeal mRNA degradation factors", "children":[ { "name":"Exosome components", "children":[ { "name":"Core exosome", "children":[ { "name":"107504549 EXOSC2; exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4" }, { "name":"107497050 exosome complex component CSL4-like\tK07573 CSL4; exosome complex component CSL4" }, { "name":"107520422 EXOSC1; exosome complex component CSL4 isoform X1\tK07573 CSL4; exosome complex component CSL4" } ] }, { "name":"Cofactors", "children":[ { "name":"107503508 EXOSC4; exosome complex component RRP41\tK11600 RRP41; exosome complex component RRP41" }, { "name":"107509081 EXOSC7; exosome complex component RRP42 isoform X2\tK12589 RRP42; exosome complex component RRP42" } ] }, { "name":"Others" } ] } ] } ] } ] }