{
	"name":"rbu02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"PG1C_07835 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"PG1C_12155 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"PG1C_07830 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"PG1C_12150 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"PG1C_12160 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"PG1C_12160 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"PG1C_12175 hypothetical protein\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"PG1C_12170 hypothetical protein\tK19118 csd2; CRISPR-associated protein Csd2"
				},
				{
					"name":"PG1C_12160 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"PG1C_12160 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins",
				"children":[
				{
					"name":"PG1C_07840 CRISPR-associated protein Csn1\tK09952 csn1; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"PG1C_12160 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"PG1C_03540 restriction endonuclease subunit R\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"PG1C_10450 restriction endonuclease subunit R\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"PG1C_10430 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"PG1C_10720 DNA methyltransferase\tK07317 K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"PG1C_02805 cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"PG1C_00655 restriction endonuclease subunit R\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"PG1C_01030 restriction endonuclease subunit R\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"PG1C_04095 restriction endonuclease\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"PG1C_05565 type III restriction enzyme, res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"PG1C_07920 type III restriction enzyme, res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"PG1C_00660 DNA methyltransferase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			},
			{
				"name":"PG1C_01035 DNA methyltransferase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			},
			{
				"name":"PG1C_04105 DNA methylase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			},
			{
				"name":"PG1C_07915 DNA methylase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"PG1C_02640 restriction endonuclease\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF",
				"children":[
				{
					"name":"PG1C_12385 toxin\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"PG1C_12380 regulator\tK19156 prlF; antitoxin PrlF"
				}
				]
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"PG1C_09185 addiction module antitoxin\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"PG1C_09190 translation repressor RelB\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"PG1C_01070 toxin of toxin-antitoxin system\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"PG1C_11405 toxin YoeB\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"PG1C_01075 antitoxin\tK19159 yefM; antitoxin YefM"
				},
				{
					"name":"PG1C_11410 hypothetical protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"PG1C_05230 phosphatidylinositol kinase\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"PG1C_08870 plasmid stabilization system protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"PG1C_08875 CopG family transcriptional regulator\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"PG1C_02520 hypothetical protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"PG1C_05355 hypothetical protein\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"PG1C_11380 excinuclease ABC subunit A\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"PG1C_05350 virulence factor\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"PG1C_11385 XRE family transcriptional regulator\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"PG1C_12690 twitching motility protein PilT\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"PG1C_00745 hypothetical protein\tK28144 vapB24S; antitoxin VapB24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"PG1C_13075 recombinase\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"PG1C_02605 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"PG1C_00070 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"PG1C_09125 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"PG1C_07395 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"PG1C_07675 hypothetical protein\tK19168 cptA; toxin CptA"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"PG1C_03115 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"PG1C_03120 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}