{
	"name":"ret03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III",
				"children":[
				{
					"name":"RHE_CH03037 fbcB; ubiquinol-cytochrome-c reductase, cytochrome b subunit protein\tK00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit"
				}
				]
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"RHE_CH00116 infB; translation initiation factor IF-2 protein\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"RHE_CH00260 infC; translation initiation factor IF-3 protein\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"RHE_CH01914 tsf; translation elongation factor Ts protein\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"RHE_CH01658 tufB; elongation factor EF-Tu protein\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"RHE_CH01673 tufA; elongation factor EF-Tu protein\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"RHE_CH01066 fusA1; elongation factor G protein\tK02355 fusA; elongation factor G"
				},
				{
					"name":"RHE_CH01672 fusA2; elongation factor G protein\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"RHE_CH01529 hypothetical conserved protein\tK17662 CBP3; cytochrome b pre-mRNA-processing protein 3"
				},
				{
					"name":"RHE_CH04022 mgpS; ATP-dependent DNA helicase protein\tK17675 SUPV3L1; ATP-dependent RNA helicase SUPV3L1\/SUV3 [EC:5.6.2.6]"
				},
				{
					"name":"RHE_CH01391 era; GTP-binding protein\tK03595 era; GTPase"
				},
				{
					"name":"RHE_CH02258 tyrS; tyrosyl-tRNA synthetase protein\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"RHE_CH04116 leuS; leucyl-tRNA synthetase protein\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"RHE_CH01497 aspS; aspartyl-tRNA synthetase protein\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"RHE_CH01818 argS; arginyl-tRNA synthetase (Arginine--tRNA ligase) protein\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"RHE_CH00218 gatA1; glutamyl-tRNA amidotransferase subunit A protein\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"RHE_CH01855 gatA2; glutamyl-tRNA amidotransferase subunit A protein\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"RHE_PE00322 probable glutamyl-tRNA amidotransferase subunit A protein\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"RHE_CH01862 gatB; glutamyl-tRNA amidotransferase subunit B protein\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"RHE_CH01854 gatC; glutamyl-tRNA amidotransferase subunit C protein\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"RHE_CH02108 ssb; single-strand DNA binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"RHE_CH01920 omp1; outer membrane lipoprotein\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"RHE_CH00145 dnaK; chaperone protein (Heat shock protein 70)\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"RHE_CH00365 grpE; molecular chaperone heat shock protein (hsp-70)\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"RHE_CH00828 groELch1; 60 kDa chaperonin, heat shock protein\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"RHE_CH01239 groELch2; 60 kDa chaperonin, heat shock protein\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"RHE_CH01271 groELch3; 60 kDa chaperonin, heat shock protein\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"RHE_PF00330 groELf; 60 kDa chaperonin, heat shock protein\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"RHE_CH00829 groESch1; 10 kDa chaperonin, heat shock protein\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"RHE_CH01238 groESch2; 10 kDa chaperonin, heat shock protein\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"RHE_CH01270 groESch3; 10 kDa chaperonin, heat shock protein\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"RHE_PF00329 groESf; 10 kDa chaperonin, heat shock protein\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"RHE_CH00144 dnaJ1; molecular chaperone protein, DnaJ family\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"RHE_CH01066 fusA1; elongation factor G protein\tK02355 fusA; elongation factor G"
				},
				{
					"name":"RHE_CH01672 fusA2; elongation factor G protein\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"RHE_CH02254 nifSch; pyridoxal-phosphate-dependent aminotransferase protein (nitrogenase cofactor synthesis protein)\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"RHE_PD00222 pyridoxal-phosphate-dependent aminotransferase protein (nitrogenase cofactor synthesis protein)\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"RHE_CH00145 dnaK; chaperone protein (Heat shock protein 70)\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"RHE_CH02304 grlA; glutaredoxin protein\tK07390 grxD; monothiol glutaredoxin"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"RHE_CH00859 probable ATP-binding protein (Mrp protein-like)\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors",
				"children":[
				{
					"name":"RHE_CH01529 hypothetical conserved protein\tK17662 CBP3; cytochrome b pre-mRNA-processing protein 3"
				}
				]
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"RHE_CH00954 ctaB; protoheme IX farnesyltransferase protein\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"RHE_CH00955 ctaG; cytochrome-c oxidase assembly protein\tK02258 COX11; cytochrome c oxidase assembly protein subunit 11"
				},
				{
					"name":"RHE_CH01565 probable cytochrome-c oxidase protein\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"RHE_CH00437 putative inner membrane transmembrane protein\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"RHE_CH00960 putative cytochrome oxidase complex biogenesis factor transmembrane protein\tK14998 SURF1; surfeit locus 1 family protein"
				},
				{
					"name":"RHE_PE00026 probable cytochrome oxidase complex biogenesis factor protein\tK14998 SURF1; surfeit locus 1 family protein"
				},
				{
					"name":"RHE_CH02829 senC; cytochrome-c oxidase assembly factor protein\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"RHE_PF00122 htpG; heat shock chaperone protein, Hsp90 family\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}