{
	"name":"rfr02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"Rfer_3907 CRISPR-associated protein, Cas1 family\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Rfer_4348 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Rfer_3908 CRISPR-associated protein, Cas2 family\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"Rfer_3901 CRISPR-associated helicase, Cas3 family\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"Rfer_3906 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"Rfer_3906 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"Rfer_3903 CRISPR-associated protein, Csd1 family\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"Rfer_3904 CRISPR-associated protein, Csd2 family\tK19118 csd2; CRISPR-associated protein Csd2"
				},
				{
					"name":"Rfer_3906 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Rfer_3902 CRISPR-associated protein, Csd5d family\tK19119 cas5d; CRISPR-associated protein Cas5d"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"Rfer_3906 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-E factors",
				"children":[
				{
					"name":"Rfer_4349 hypothetical protein\tK19126 casE; CRISPR system Cascade subunit CasE"
				}
				]
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"Rfer_3906 CRISPR-associated exonuclease, Cas4 family\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"Rfer_0028 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_1062 type III restriction enzyme, res subunit\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_1367 type III restriction enzyme, res subunit\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_4010 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_0030 restriction modification system DNA specificity domain\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_1060 restriction modification system DNA specificity domain\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_1366 putative type I site-specific restriction-modification system, S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_4007 Restriction endonuclease S subunits-like\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Rfer_0032 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Rfer_1059 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Rfer_1365 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Rfer_4006 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases",
				"children":[
				{
					"name":"Rfer_4209 hypothetical protein\tK01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]"
				}
				]
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"Rfer_1822 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"Rfer_3077 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"Rfer_1819 restriction endonuclease\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"Rfer_1750 conserved hypothetical protein\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Rfer_1749 RelB antitoxin\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"Rfer_2987 CcdB-like toxin protein\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"Rfer_2988 potential post-segregation antitoxin\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"Rfer_3404 Death-on-curing protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"Rfer_4450 plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"Rfer_4449 plasmid maintenance system antidote protein, XRE family\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"Rfer_0624 PilT protein-like\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"Rfer_3052 Twin-arginine translocation pathway signal\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Rfer_3420 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Rfer_3923 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Rfer_2641 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"Rfer_2642 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"Rfer_2681 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"Rfer_1797 protein of unknown function DUF339\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"Rfer_2177 cysteine desulfurase IscS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"Rfer_4334 conserved hypothetical protein\tK19170 dndC; DNA sulfur modification protein DndC"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}