{
	"name":"rge02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"RGE_33130 phoR; phosphate regulon sensor protein PhoR\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"RGE_33140 phoB; phosphate regulon transcriptional regulatory protein PhoB\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"RGE_18310 sensor protein\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"RGE_26890 ompB; osmolarity sensor protein OmpB\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"RGE_18300 two component transcriptional regulator, winged helix family\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			},
			{
				"name":"RGE_26880 ompR; DNA-binding response regulator OmpR\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)",
			"children":[
			{
				"name":"RGE_05420 creC; sensory histidine kinase CreC\tK07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]"
			},
			{
				"name":"RGE_05430 creB; DNA-binding response regulator CreB\tK07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB"
			}
			]
		},
		{
			"name":"BaeS-BaeR (envelope stress response)",
			"children":[
			{
				"name":"RGE_09040 baeS; putative signal transduction histidine-protein kinase BaeS\tK07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]"
			},
			{
				"name":"RGE_09050 baeR; DNA-binding transcriptional regulator BaeR\tK07664 baeR; two-component system, OmpR family, response regulator BaeR"
			}
			]
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"QseC-QseB (quorum sensing)",
			"children":[
			{
				"name":"RGE_09270 qseC; sensor protein QseC\tK07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]"
			},
			{
				"name":"RGE_30140 qseC; sensor protein QseC\tK07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]"
			},
			{
				"name":"RGE_09260 qseB; transcriptional regulatory protein QseB\tK07666 qseB; two-component system, OmpR family, response regulator QseB"
			},
			{
				"name":"RGE_30130 qseB; two-component system response regulator QseB\tK07666 qseB; two-component system, OmpR family, response regulator QseB"
			}
			]
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"RGE_20680 kdpD; two-component system, sensor kinase protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"RGE_20670 kdpE; two-component system response regulator KdpE\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)"
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR",
			"children":[
			{
				"name":"RGE_29550 sensor protein\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
			},
			{
				"name":"RGE_29540 two component transcriptional regulator, winged helix family\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
			}
			]
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"RGE_07370 sensor protein\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"RGE_07380 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"RGE_17290 two-component response regulatory protein\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"RGE_18450 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"RGE_27080 response regulator receiver protein CheY-like\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"RGE_46610 two component transcriptional regulator, winged helix family\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)",
			"children":[
			{
				"name":"RGE_23360 integral membrane sensor signal transduction histidine kinase\tK07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]"
			},
			{
				"name":"RGE_40500 integral membrane sensor signal transduction histidine kinase\tK07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]"
			},
			{
				"name":"RGE_40700 sensor protein\tK07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)",
			"children":[
			{
				"name":"RGE_10170 two component transcriptional regulator, LuxR family\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			},
			{
				"name":"RGE_23350 two component transcriptional regulator, LuxR family\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			},
			{
				"name":"RGE_39320 two component transcriptional regulator, LuxR family\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			},
			{
				"name":"RGE_40490 gacA; two component transcriptional regulator, LuxR family\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			}
			]
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)",
			"children":[
			{
				"name":"RGE_20130 putative periplasmic sensor hybrid histidine kinase\tK07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)",
			"children":[
			{
				"name":"RGE_19330 integral membrane sensor signal transduction histidine kinase\tK07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]"
			},
			{
				"name":"RGE_19340 two component transcriptional regulator, LuxR family\tK07693 desR; two-component system, NarL family, response regulator DesR"
			}
			]
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)",
			"children":[
			{
				"name":"RGE_23190 citA; sensor kinase CitA\tK07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]"
			},
			{
				"name":"RGE_23200 citB; transcriptional regulator CitB\tK07702 dpiA; two-component system, CitB family, response regulator CitB"
			}
			]
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)",
			"children":[
			{
				"name":"RGE_36500 algZ; two-component system sensor protein, alginate biosynthesis\tK08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]"
			},
			{
				"name":"RGE_36490 algR; two component transcriptional regulator, LytTR family\tK08083 algR; two-component system, LytTR family, response regulator AlgR"
			}
			]
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)",
			"children":[
			{
				"name":"RGE_17570 lytS; two-component system, LytT family, sensor histidine kinase LytS\tK27882 btsS; two-component system, LytTR family, low-concentration pyruvate sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"RGE_07120 two component transcriptional regulator, LytTR family\tK27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator"
			},
			{
				"name":"RGE_17560 lytT; two component transcriptional regulator, LytTR family\tK27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator"
			}
			]
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"RGE_14390 ntrB; signal transduction histidine kinase, nitrogen specific, NtrB\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"RGE_14400 ntrC; nitrogen metabolism transcriptional regulator NtrC\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)",
			"children":[
			{
				"name":"RGE_44620 ntrY; nitrogen regulation protein NtrY\tK13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]"
			},
			{
				"name":"RGE_44610 two component transcriptional regulator, Fis family\tK13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX"
			}
			]
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)",
			"children":[
			{
				"name":"RGE_09900 atoS; signal transduction histidine-protein kinase AtoS\tK07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]"
			},
			{
				"name":"RGE_09890 atoC; acetoacetate metabolism regulatory protein AtoC\tK07714 atoC; two-component system, NtrC family, response regulator AtoC"
			}
			]
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)",
			"children":[
			{
				"name":"RGE_42350 pilS; two-component system sensor kinase PilS\tK02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]"
			},
			{
				"name":"RGE_42340 pilR; two-component system response regulator PilR\tK02667 pilR; two-component system, NtrC family, response regulator PilR"
			}
			]
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)"
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)",
			"children":[
			{
				"name":"RGE_36080 PAS\/PAC sensor hybrid histidine kinase\tK19661 hupT; two-component system, NtrC family, sensor histidine kinase HupT\/HoxJ [EC:2.7.13.3]"
			},
			{
				"name":"RGE_35940 hupR; hydrogenase transcriptional regulator HupR\tK19641 hupR; two-component system, NtrC family, response regulator HupR\/HoxA"
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"RGE_04050 two component, sigma54 specific, transcriptional regulator, Fis family\tK02481 flgR; two-component system, NtrC family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"RGE_37450 cheA; chemotaxis sensor histidine kinase CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"RGE_39360 cheA; chemotaxis sensor histidine kinase CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"RGE_05050 response regulator receiver protein CheY-like\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"RGE_07060 response regulator receiver protein CheY-like\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"RGE_17080 cheY; chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"RGE_37470 response regulator receiver protein CheY-like\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"RGE_39350 cheY; chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"RGE_35440 cheB; protein-glutamate methylesterase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"RGE_37400 cheB; protein-glutamate methylesterase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"RGE_36420 methyltransferase\/methylesterase, CheR\/CheB with PAS\/PAC sensor\tK13924 cheBR; two-component system, chemotaxis family, CheB\/CheR fusion protein [EC:2.1.1.80 3.1.1.61]"
			},
			{
				"name":"RGE_46370 methyltransferase\/methylesterase, CheR\/CheB with PAS\/PAC sensor\tK13924 cheBR; two-component system, chemotaxis family, CheB\/CheR fusion protein [EC:2.1.1.80 3.1.1.61]"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)",
			"children":[
			{
				"name":"RGE_42070 pilL; PilL protein\tK06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase\/response regulator)"
			},
			{
				"name":"RGE_42110 pilG; twitching motility, CheY-like protein PilG\tK02657 pilG; twitching motility two-component system response regulator PilG"
			},
			{
				"name":"RGE_42100 pilH; twitching motility protein PilH\tK02658 pilH; twitching motility two-component system response regulator PilH"
			}
			]
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"RGE_45240 PAS\/PAC sensor hybrid histidine kinase\tK11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)",
			"children":[
			{
				"name":"RGE_28830 histidine kinase\tK13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)",
			"children":[
			{
				"name":"RGE_28820 two component transcriptional regulator, LuxR family\tK14987 fixJ; two-component system, LuxR family, response regulator FixJ"
			}
			]
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)"
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)",
			"children":[
			{
				"name":"RGE_14770 sensor protein\tK20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]"
			},
			{
				"name":"RGE_22740 PAS\/PAC sensor hybrid histidine kinase\tK20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]"
			},
			{
				"name":"RGE_17410 Hpt domain protein\tK20976 hptB; histidine phosphotransfer protein HptB"
			}
			]
		},
		{
			"name":"PdtaS-PdtaR",
			"children":[
			{
				"name":"RGE_17390 response regulator receiver protein CheY-like\tK22010 pdtaR; two-component system, response regulator PdtaR"
			}
			]
		},
		{
			"name":"NasS-NasT"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"RGE_42940 PAS\/PAC sensor hybrid histidine kinase\tK11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]"
			}
			]
		}
		]
	}
	]
}