{
	"name":"rhn02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins"
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"AMJ98_CH01036 hsdR; type I site-specific deoxyribonuclease subunit HsdR\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"AMJ98_CH01034 hsdS; type 1 restriction-modification system protein HsdS\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"AMJ98_CH01035 hsdM; type 1 restriction-modification system protein HsdM\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"AMJ98_CH01010 ccrM; site-specific (adenine-specific) DNA-methyltransferase\tK13581 ccrM; modification methylase [EC:2.1.1.72]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"AMJ98_CH01032 mrr; restriction endonuclease protein Mrr\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"AMJ98_PA00088 hypothetical protein\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"AMJ98_CH00255 plasmid maintenance toxin\/cell growth inhibitor CcdB protein\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"AMJ98_CH00256 post-segregation antitoxin CcdA protein\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"AMJ98_CH01016 toxin-antitoxin system toxin RelE\/ParE family protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"AMJ98_CH02894 toxin-antitoxin system toxin RelE\/ParE family protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"AMJ98_PB00001 toxin-antitoxin system toxin RelE\/ParE family protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"AMJ98_PB00047 hypothetical protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"AMJ98_PE00110 toxin-antitoxin system toxin RelE\/ParE family protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"AMJ98_CH01015 addiction module antidote protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"AMJ98_CH01175 ribbon-helix-helix domain-containing protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"AMJ98_CH02893 ribbon-helix-helix domain-containing protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"AMJ98_PB00046 ribbon-helix-helix domain-containing protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"AMJ98_PE00109 hypothetical protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"AMJ98_PA00078 Fic\/DOC family protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"AMJ98_PE00008 vapC-2; toxin\/antitoxin system endonuclease protein VapC 2\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"AMJ98_PE00009 vapB-2; toxin-antitoxin system antitoxin protein VapB 2\tK18829 mvpT; antitoxin VapB"
				},
				{
					"name":"AMJ98_CH03314 PilT domain-containing protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"AMJ98_PC00192 PilT domain-containing protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"AMJ98_CH03315 type II toxin-antitoxin system antitoxin Phd\/YefM family protein\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"AMJ98_CH00324 antitoxin protein\tK19687 vapB28S; antitoxin VapB28\/30\/34\/36\/42"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"AMJ98_CH00432 toxin\/antitoxin system PilT domain-containing protein\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"AMJ98_PB00223 toxin\/antitoxin system PilT domain-containing protein\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"AMJ98_CH00431 ribbon-helix-helix domain-containing protein\tK21495 fitA; antitoxin FitA"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"AMJ98_CH02783 ftsZ-1; cell division protein FtsZ 1\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"AMJ98_CH03006 ftsZ-2; cell division protein FtsZ 2\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"AMJ98_CH01541 parC; DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"AMJ98_CH02240 gyrB-2; DNA gyrase subunit B 2\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"AMJ98_CH03888 gltX; glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"AMJ98_CH02146 Sdh5 family protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"AMJ98_CH02308 nifS-1; cysteine desulfurase 1\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"AMJ98_PC00273 nifS-2; cysteine desulfurase 2\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}