{
	"name":"rhor03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P"
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"ONR75_26200 ribonuclease T2\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex"
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"ONR75_19665 gltX; (GenBank) glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"ONR75_19805 proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"ONR75_01455 leuS; (GenBank) leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"ONR75_17685 metG; (GenBank) methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"ONR75_19660 glutamine--tRNA ligase\/YqeY domain fusion protein\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"ONR75_19290 argS; (GenBank) arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"ONR75_20065 aspS; (GenBank) aspartate--tRNA ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"ONR75_12630 alaS; (GenBank) alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"ONR75_19250 serS; (GenBank) serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"ONR75_17500 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"ONR75_26240 hisS; (GenBank) histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"ONR75_01090 pheS; (GenBank) phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"ONR75_01095 pheT; (GenBank) phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"ONR75_16815 tyrS; (GenBank) tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"ONR75_00455 trpS; (GenBank) tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors"
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"ONR75_15045 HIT family protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"ONR75_02305 mtaB; (GenBank) tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"ONR75_00385 tRNA (guanine(46)-N(7))-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"ONR75_05940 truA; (GenBank) tRNA pseudouridine(38-40) synthase TruA\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"ONR75_00350 truB; (GenBank) tRNA pseudouridine(55) synthase TruB\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"ONR75_06175 nifS; (GenBank) cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"ONR75_16845 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex"
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"ONR75_07845 L-threonylcarbamoyladenylate synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"ONR75_24400 miaA; (GenBank) tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"ONR75_01415 mnmE; (GenBank) tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors",
				"children":[
				{
					"name":"ONR75_10460 3'(2'),5'-bisphosphate nucleotidase CysQ\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]"
				}
				]
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"ONR75_27785 rnpB; (GenBank) RNase P RNA component class A\tK01978 rnpB; RNase P catalytic RNA component"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"ONR75_01210 rph; (GenBank) ribonuclease PH\tK00989 rph; ribonuclease PH [EC:2.7.7.56]"
				},
				{
					"name":"ONR75_00925 ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				},
				{
					"name":"ONR75_20080 rnd; (GenBank) ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				},
				{
					"name":"ONR75_26200 ribonuclease T2\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases"
			},
			{
				"name":"tRNA splicing ligases"
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"ONR75_02420 thpR; (GenBank) RNA 2',3'-cyclic phosphodiesterase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"ONR75_28040 ettA; (GenBank) energy-dependent translational throttle protein EttA\tK06020 ettA; energy-dependent translational throttle protein EttA"
				}
				]
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"ONR75_01455 leuS; (GenBank) leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"ONR75_04475 lysine--tRNA ligase\tK04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]"
				},
				{
					"name":"ONR75_19805 proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"ONR75_16815 tyrS; (GenBank) tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"ONR75_00455 trpS; (GenBank) tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"ONR75_12630 alaS; (GenBank) alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"ONR75_17500 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"ONR75_17685 metG; (GenBank) methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"ONR75_19250 serS; (GenBank) serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"ONR75_20065 aspS; (GenBank) aspartate--tRNA ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"ONR75_07130 glycine--tRNA ligase subunit alpha\tK01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]"
				},
				{
					"name":"ONR75_07140 glyS; (GenBank) glycine--tRNA ligase subunit beta\tK01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]"
				},
				{
					"name":"ONR75_19665 gltX; (GenBank) glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"ONR75_19660 glutamine--tRNA ligase\/YqeY domain fusion protein\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"ONR75_19290 argS; (GenBank) arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"ONR75_01090 pheS; (GenBank) phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"ONR75_01095 pheT; (GenBank) phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"ONR75_26240 hisS; (GenBank) histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"ONR75_05465 gluQRS; (GenBank) tRNA glutamyl-Q(34) synthetase GluQRS\tK01894 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"ONR75_25695 ybaK; (GenBank) Cys-tRNA(Pro) deacylase\tK03976 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases",
				"children":[
				{
					"name":"ONR75_26365 nucleoside deaminase\tK11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]"
				}
				]
			},
			{
				"name":"Dihydorouridine synthases",
				"children":[
				{
					"name":"ONR75_21360 dusA; (GenBank) tRNA dihydrouridine(20\/20a) synthase DusA\tK05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]"
				},
				{
					"name":"ONR75_17530 dusB; (GenBank) tRNA dihydrouridine synthase DusB\tK05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]"
				}
				]
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"ONR75_02305 mtaB; (GenBank) tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"ONR75_12665 TrmJ\/YjtD family RNA methyltransferase\tK02533 lasT; tRNA\/rRNA methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"ONR75_19175 trmFO; (GenBank) methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO\tK04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]"
				},
				{
					"name":"ONR75_00385 tRNA (guanine(46)-N(7))-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"ONR75_01415 mnmE; (GenBank) tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"ONR75_29455 tRNA methyltransferase\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"ONR75_05940 truA; (GenBank) tRNA pseudouridine(38-40) synthase TruA\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"ONR75_00350 truB; (GenBank) tRNA pseudouridine(55) synthase TruB\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"ONR75_02320 RNA pseudouridine synthase\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"ONR75_28930 mnmA; (GenBank) tRNA 2-thiouridine(34) synthase MnmA\tK00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]"
				},
				{
					"name":"ONR75_11440 sulfurtransferase TusA family protein\tK04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]"
				},
				{
					"name":"ONR75_16875 iron-sulfur cluster assembly accessory protein\tK13628 iscA; iron-sulfur cluster assembly protein"
				},
				{
					"name":"ONR75_06175 nifS; (GenBank) cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"ONR75_16845 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"ONR75_28820 folate-binding protein\tK06980 ygfZ; tRNA-modifying protein YgfZ"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"ONR75_24400 miaA; (GenBank) tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"ONR75_19065 queA; (GenBank) tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA\tK07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]"
				},
				{
					"name":"ONR75_17575 queC; (GenBank) 7-cyano-7-deazaguanine synthase QueC\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"ONR75_29470 6-carboxytetrahydropterin synthase\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"ONR75_29465 queE; (GenBank) 7-carboxy-7-deazaguanine synthase\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"ONR75_19475 queF; (GenBank) preQ(1) synthase\tK09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]"
				},
				{
					"name":"ONR75_01055 queG; (GenBank) tRNA epoxyqueuosine(34) reductase QueG\tK18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]"
				},
				{
					"name":"ONR75_19060 tgt; (GenBank) tRNA guanosine(34) transglycosylase Tgt\tK00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]"
				},
				{
					"name":"ONR75_26665 tilS; (GenBank) tRNA lysidine(34) synthetase TilS\tK04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]"
				},
				{
					"name":"ONR75_00435 tsaB; (GenBank) tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB\tK14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB"
				},
				{
					"name":"ONR75_07845 L-threonylcarbamoyladenylate synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"ONR75_15120 rnr; (GenBank) ribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
			},
			{
				"name":"ONR75_00335 pnp; (GenBank) polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
			}
			]
		}
		]
	}
	]
}