{
	"name":"rme01011",
	"children":[
	{
		"name":"Precursor biosynthesis",
		"children":[
		{
			"name":"Transferase\/Dehydrogenase",
			"children":[
			{
				"name":"Rmet_3250 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase\tK00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]"
			},
			{
				"name":"Rmet_2900 murB; UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding protein\tK00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]"
			}
			]
		},
		{
			"name":"Amino acid ligase",
			"children":[
			{
				"name":"Rmet_3127 murC; UDP-N-acetylmuramate:L-alanine ligase\tK01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]"
			},
			{
				"name":"Rmet_3130 murD; UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase\tK01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]"
			},
			{
				"name":"Rmet_3133 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase\tK01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]"
			},
			{
				"name":"Rmet_3126 ddlB; D-alanine:D-alanine ligase\tK01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]"
			}
			]
		},
		{
			"name":"Racemase",
			"children":[
			{
				"name":"Rmet_1400 dadX; alanine racemase 2, PLP-binding protein\tK01775 alr; alanine racemase [EC:5.1.1.1]"
			},
			{
				"name":"Rmet_2274 murI; glutamate racemase\tK01776 murI; glutamate racemase [EC:5.1.1.3]"
			}
			]
		},
		{
			"name":"Carboxypeptidase",
			"children":[
			{
				"name":"Rmet_1574 ldcA; L,D-carboxypeptidase A\tK01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"Rmet_3131 mraY; phospho-N-acetylmuramoyl-pentapeptide transferase\tK01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]"
			},
			{
				"name":"Rmet_3128 murG; N-acetylglucosaminyl transferase\tK02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]"
			}
			]
		},
		{
			"name":"Diphosphatase",
			"children":[
			{
				"name":"Rmet_2705 bacA; undecaprenyl pyrophosphate phosphatase\tK06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]"
			},
			{
				"name":"Rmet_3000 mmfB; undecaprenyl pyrophosphate phosphatase (Tn6048)\tK19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]"
			},
			{
				"name":"Rmet_4035 mmfB; undecaprenyl pyrophosphate phosphatase (Tn6048)\tK19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]"
			},
			{
				"name":"Rmet_4982 mmfB; undecaprenyl pyrophosphate phosphatase (Tn6048)\tK19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]"
			}
			]
		},
		{
			"name":"Flippase",
			"children":[
			{
				"name":"Rmet_2905 mviN; Integral membrane protein MviN; MviN family of virulence factors\tK03980 murJ; putative peptidoglycan lipid II flippase"
			}
			]
		}
		]
	},
	{
		"name":"Peptidoglycan biosynthesis and degradation",
		"children":[
		{
			"name":"Glycosyltransferase\/DD-Transpeptidase (Class A PBP)",
			"children":[
			{
				"name":"Rmet_2152 mrcA1; transpeptidase\/transglycosylase (peniciline binding)\tK05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]"
			},
			{
				"name":"Rmet_3274 mrcA; Penicillin-binding protein 1A (PBP-1a): murein transglycosylase; murein transpeptidase\tK05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]"
			},
			{
				"name":"Rmet_3992 mrcB; fused peptidoglycan glycosyl transferase; transpeptidase\tK05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]"
			},
			{
				"name":"Rmet_4835 peptidoglycan glycosyl transferase\tK05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]"
			},
			{
				"name":"Rmet_3529 pbpC; fused transglycosylase; transpeptidase; penicillin binding protein\tK05367 pbpC; penicillin-binding protein 1C [EC:2.4.99.28]"
			}
			]
		},
		{
			"name":"DD-Transpeptidase (Class B PBP)",
			"children":[
			{
				"name":"Rmet_0054 mrdA; transpeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2)\tK05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]"
			},
			{
				"name":"Rmet_2151 ftsI1; peptidoglycan glycosyltransferase (penicillin-binding domain)\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]"
			},
			{
				"name":"Rmet_3134 ftsI; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3)\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]"
			}
			]
		},
		{
			"name":"DD-Carboxypeptidase\/DD-Endopeptidase (Low molecular weight PBP)",
			"children":[
			{
				"name":"Rmet_0225 dac; D-alanyl-D-alanine carboxypeptidase\tK07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5\/6) [EC:3.4.16.4]"
			},
			{
				"name":"Rmet_0508 dacB; D-Alanyl-D-alanine carboxypeptidase, S13 family\tK07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase\/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]"
			},
			{
				"name":"Rmet_1204 peptidase S11, D-alanyl-D-alanine carboxypeptidase 1\tK07262 pbpG; serine-type D-Ala-D-Ala endopeptidase (penicillin-binding protein 7) [EC:3.4.21.-]"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"Rmet_3053 mtgA; monofunctional biosynthetic peptidoglycan transglycosylase\tK03814 mtgA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
			},
			{
				"name":"Rmet_3129 ftsW; integral membrane protein involved in stabilizing FstZ ring during cell division\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
			},
			{
				"name":"Rmet_0055 mrdB; cell wall shape-determining protein MrdB\tK05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
			}
			]
		},
		{
			"name":"Transpeptidase",
			"children":[
			{
				"name":"Rmet_3815 conserved hypothetical protein (peptidoglycan-binding domain)\tK21470 ldtD; L,D-transpeptidase"
			}
			]
		},
		{
			"name":"Carboxypeptidase"
		},
		{
			"name":"Endopeptidase"
		},
		{
			"name":"Sortase"
		},
		{
			"name":"Lytic transglycosylase",
			"children":[
			{
				"name":"Rmet_0176 soluble lytic murein transglycosylase\tK08309 slt; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			},
			{
				"name":"Rmet_3173 mltA; Membrane-bound lytic murein transglycosylase\tK08304 mltA; peptidoglycan lytic transglycosylase A [EC:4.2.2.29]"
			},
			{
				"name":"Rmet_0732 mltB; membrane-bound lytic murein transglycosylase B\tK08305 mltB; peptidoglycan lytic transglycosylase B [EC:4.2.2.29]"
			},
			{
				"name":"Rmet_2205 soluble lytic murein transglycosylase or related regulatory protein\tK08307 mltD; peptidoglycan lytic transglycosylase D [EC:4.2.2.29]"
			},
			{
				"name":"Rmet_1829 yceG; conserved hypothetical protein\tK07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29]"
			},
			{
				"name":"Rmet_3432 rare lipoprotein A-family protein\tK03642 rlpA; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			},
			{
				"name":"Rmet_4287 rlpA; rare lipoprotein A\tK03642 rlpA; peptidoglycan lytic transglycosylase [EC:4.2.2.29]"
			}
			]
		},
		{
			"name":"Amidase",
			"children":[
			{
				"name":"Rmet_0526 amiC; N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
			},
			{
				"name":"Rmet_3089 ampD; N-acetyl-anhydromuranmyl-L-alanine amidase\tK03806 ampD; N-acetyl-anhydromuramoyl-L-alanine amidase [EC:3.5.1.28]"
			}
			]
		},
		{
			"name":"Structural protein"
		}
		]
	}
	]
}