{
	"name":"rnc02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"GO999_07440 phoR; phosphate regulon sensor histidine kinase PhoR\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"GO999_07435 phoB; phosphate regulon transcriptional regulatory protein PhoB\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			},
			{
				"name":"GO999_16620 response regulator\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"GO999_08100 HAMP domain-containing protein\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"GO999_20025 HAMP domain-containing protein\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"GO999_08105 ompR; two-component system response regulator OmpR\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			},
			{
				"name":"GO999_20030 response regulator\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)",
			"children":[
			{
				"name":"GO999_19865 HAMP domain-containing protein\tK07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]"
			},
			{
				"name":"GO999_19860 response regulator\tK07664 baeR; two-component system, OmpR family, response regulator BaeR"
			}
			]
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)",
			"children":[
			{
				"name":"GO999_17330 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"GO999_24345 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"GO999_17335 heavy metal response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"GO999_24350 heavy metal response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			}
			]
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"GO999_00330 DUF4118 domain-containing protein\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"GO999_01440 kdpE; two-component system response regulator KdpE\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)",
			"children":[
			{
				"name":"GO999_00290 sensor histidine kinase\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"GO999_02245 HAMP domain-containing protein\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"GO999_08310 HAMP domain-containing protein\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"GO999_00295 response regulator\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			},
			{
				"name":"GO999_02250 response regulator\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			},
			{
				"name":"GO999_08315 response regulator\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			}
			]
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR",
			"children":[
			{
				"name":"GO999_23525 HAMP domain-containing protein\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
			},
			{
				"name":"GO999_23520 response regulator\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
			}
			]
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"GO999_00240 two-component sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"GO999_01555 two-component sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"GO999_21625 two-component sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"GO999_00235 response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"GO999_01550 response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"GO999_13870 response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"GO999_21630 response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)",
			"children":[
			{
				"name":"GO999_18910 HAMP domain-containing protein\tK07673 narX; two-component system, NarL family, nitrate\/nitrite sensor histidine kinase NarX [EC:2.7.13.3]"
			},
			{
				"name":"GO999_18915 response regulator\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			}
			]
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)",
			"children":[
			{
				"name":"GO999_21995 response regulator\tK07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]"
			},
			{
				"name":"GO999_00315 response regulator\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			},
			{
				"name":"GO999_01490 response regulator\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			},
			{
				"name":"GO999_21990 response regulator\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			}
			]
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)"
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"GO999_05330 PAS domain-containing protein\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"GO999_16600 histidine kinase\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"GO999_10115 PAS domain-containing sensor histidine kinase\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"GO999_10110 ntrC; nitrogen regulation protein NR(I)\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)",
			"children":[
			{
				"name":"GO999_16320 HAMP domain-containing protein\tK13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]"
			},
			{
				"name":"GO999_16315 response regulator\tK13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX"
			}
			]
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)",
			"children":[
			{
				"name":"GO999_02915 PAS domain-containing protein\tK02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]"
			},
			{
				"name":"GO999_02920 response regulator\tK02667 pilR; two-component system, NtrC family, response regulator PilR"
			}
			]
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"GO999_15070 two-component sensor histidine kinase\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"GO999_22290 sensor histidine kinase\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"GO999_15065 response regulator\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			},
			{
				"name":"GO999_22295 response regulator\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			}
			]
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"GO999_20945 cheA; chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"GO999_12860 cheY; chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"GO999_20915 cheY; chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"GO999_20950 response regulator\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"GO999_20920 cheB; chemotaxis-specific protein-glutamate methyltransferase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"GO999_17030 response regulator\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)",
			"children":[
			{
				"name":"GO999_13225 response regulator\tK06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase\/response regulator)"
			},
			{
				"name":"GO999_13245 response regulator\tK02657 pilG; twitching motility two-component system response regulator PilG"
			},
			{
				"name":"GO999_13240 response regulator\tK02658 pilH; twitching motility two-component system response regulator PilH"
			}
			]
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)",
			"children":[
			{
				"name":"GO999_02315 sensor histidine kinase\tK10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase\/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]"
			}
			]
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)",
			"children":[
			{
				"name":"GO999_09710 sensor histidine kinase\tK17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]"
			},
			{
				"name":"GO999_09705 response regulator\tK17061 aauR; two-component system, response regulator AauR"
			}
			]
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)",
			"children":[
			{
				"name":"GO999_16510 sensor histidine kinase\tK15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]"
			},
			{
				"name":"GO999_16505 response regulator\tK15012 regA; two-component system, response regulator RegA"
			}
			]
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ",
			"children":[
			{
				"name":"GO999_03270 GHKL domain-containing protein\tK19621 phcS; two-component system, sensor histidine kinase PhcS [EC:2.7.13.3]"
			},
			{
				"name":"GO999_03265 response regulator\tK19622 phcR; two-component system, response regulator PhcR"
			},
			{
				"name":"GO999_03260 response regulator\tK19623 phcQ; two-component system, probable response regulator PhcQ"
			}
			]
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT",
			"children":[
			{
				"name":"GO999_14770 ANTAR domain-containing protein\tK07183 nasT; two-component system, response regulator \/ RNA-binding antiterminator"
			}
			]
		},
		{
			"name":"Unclassified"
		}
		]
	}
	]
}