{
	"name":"rpm02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"RSPPHO_01296 cas1; CRISPR-associated protein Cas1, putative\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"RSPPHO_02010 CRISPR-associated protein, Cas1 family\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"RSPPHO_01295 cas2; CRISPR-associated protein Cas2, putative\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"RSPPHO_02009 CRISPR-associated protein, Cas2 family\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"RSPPHO_02015 CRISPR-associated helicase, Cas3 family\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors",
				"children":[
				{
					"name":"RSPPHO_01293 CRISPR-associated protein, CT1972 family\tK19123 casA; CRISPR system Cascade subunit CasA"
				},
				{
					"name":"RSPPHO_02014 CRISPR-associated protein, Cse1 family\tK19123 casA; CRISPR system Cascade subunit CasA"
				},
				{
					"name":"RSPPHO_01292 CRISPR-associated protein, CT1973 family\tK19046 casB; CRISPR system Cascade subunit CasB"
				},
				{
					"name":"RSPPHO_01291 CRISPR-associated protein, CT1975 family\tK19124 casC; CRISPR system Cascade subunit CasC"
				},
				{
					"name":"RSPPHO_02013 CRISPR-associated protein, Cse4 family\tK19124 casC; CRISPR system Cascade subunit CasC"
				},
				{
					"name":"RSPPHO_01290 CRISPR-associated protein, CT1976 family\tK19125 casD; CRISPR system Cascade subunit CasD"
				},
				{
					"name":"RSPPHO_02012 CRISPR-associated protein, Cas5e family\tK19125 casD; CRISPR system Cascade subunit CasD"
				},
				{
					"name":"RSPPHO_01289 CRISPR-associated protein, CT1974 family\tK19126 casE; CRISPR system Cascade subunit CasE"
				},
				{
					"name":"RSPPHO_02011 CRISPR-associated protein, CT1974\tK19126 casE; CRISPR system Cascade subunit CasE"
				}
				]
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"RSPPHO_02905 hsdR_2; Type I restriction-modification system (Restriction subunit)\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"RSPPHO_02907 hsdS; Type I restriction-modification system, S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"RSPPHO_02906 hsdS_2; Type I restriction-modification system (Specificity subunit)\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"RSPPHO_00743 DNA methylase N-4\/N-6\tK13581 ccrM; modification methylase [EC:2.1.1.72]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"RSPPHO_02166 Type III restriction enzyme, res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"RSPPHO_01284 Possible restriction system protein\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"RSPPHO_01754 Transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"ChpB-ChpS",
				"children":[
				{
					"name":"RSPPHO_02507 pemI; PemI protein\tK18842 chpS; antitoxin ChpS"
				}
				]
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"RSPPHO_02045 Putative uncharacterized protein\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"RSPPHO_00424 Plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"RSPPHO_00058 Plasmid maintenance system antidote protein\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"RSPPHO_00425 Plasmid maintenance system antidote protein\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"RSPPHO_01440 Putative plasmid stability-like protein\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"RSPPHO_02972 stbB; Plasmid stability protein StbB, putative\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"RSPPHO_02654 Cell division protein ftsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"RSPPHO_01281 Rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"RSPPHO_02800 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"RSPPHO_01785 Gram negative topoisomerase IV, subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"RSPPHO_00650 gltX1; Glutamyl-tRNA synthetase 1\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"RSPPHO_01185 gltX2; Glutamyl-tRNA synthetase 2\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"RSPPHO_02460 Putative uncharacterized protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"RSPPHO_02102 Cysteine sulfinate desulfinase\/cysteine desulfurase and related enzyme\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"RSPPHO_02567 Aminotransferase, class V\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"RSPPHO_02103 ABC transporter ATP-binding protein\tK19171 dndD; DNA sulfur modification protein DndD"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}