{
	"name":"sant03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III"
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"QR300_13270 infB; translation initiation factor IF-2\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"QR300_09275 infC; translation initiation factor IF-3\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"QR300_13515 tsf; translation elongation factor Ts\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"QR300_07160 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"QR300_19035 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"QR300_08765 elongation factor G-like protein EF-G2\tK02355 fusA; elongation factor G"
				},
				{
					"name":"QR300_19040 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"QR300_28660 era; GTPase Era\tK03595 era; GTPase"
				},
				{
					"name":"QR300_32760 tyrS; tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"QR300_28485 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"QR300_21490 aspS; aspartate--tRNA ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"QR300_28860 glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"QR300_15000 DALR anticodon-binding domain-containing protein\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"QR300_19670 argS; arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"QR300_39900 argS; arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"QR300_14090 gatA; Asp-tRNA(Asn)\/Glu-tRNA(Gln) amidotransferase subunit GatA\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"QR300_27020 amidase\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"QR300_41180 amidase\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"QR300_14080 gatB; Asp-tRNA(Asn)\/Glu-tRNA(Gln) amidotransferase subunit GatB\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"QR300_14095 gatC; Asp-tRNA(Asn)\/Glu-tRNA(Gln) amidotransferase subunit GatC\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"QR300_22050 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"QR300_28025 single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex"
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"QR300_04980 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"QR300_20900 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"QR300_35530 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"QR300_20895 grpE; nucleotide exchange factor GrpE\tK03687 GRPE; molecular chaperone GrpE"
				},
				{
					"name":"QR300_35535 nucleotide exchange factor GrpE\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"QR300_18600 groL; chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"QR300_24200 groL; chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"QR300_18605 groES; co-chaperone GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"QR300_26625 co-chaperone GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"QR300_20890 dnaJ; molecular chaperone DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				},
				{
					"name":"QR300_28600 dnaJ; molecular chaperone DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"QR300_08765 elongation factor G-like protein EF-G2\tK02355 fusA; elongation factor G"
				},
				{
					"name":"QR300_19040 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"QR300_14160 cysteine desulfurase family protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"QR300_31135 aminotransferase class V-fold PLP-dependent enzyme\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"QR300_04980 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"QR300_20900 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"QR300_35530 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"QR300_16135 Mrp\/NBP35 family ATP-binding protein\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"QR300_32255 heme o synthase\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"QR300_32270 COX15\/CtaA family protein\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"QR300_21935 yidC; membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"QR300_26675 membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"QR300_22370 SCO family protein\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"QR300_40020 htpG; molecular chaperone HtpG\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}