{
	"name":"sauf01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"X998_0117 tet(38); tetracycline efflux MFS transporter Tet(38)\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"X998_0139 acetyltransferase\tK00638 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]",
				"children":[
				{
					"name":"X998_0036 beta-lactam sensor\/signal transducer MecR1\tK02547 mecR1; methicillin resistance protein"
				},
				{
					"name":"X998_0034 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA\tK02545 mecA; penicillin-binding protein 2 prime [EC:3.4.16.4]"
				}
				]
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]",
				"children":[
				{
					"name":"X998_0735 MarR family transcriptional regulator\tK18906 mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA"
				},
				{
					"name":"X998_0117 tet(38); tetracycline efflux MFS transporter Tet(38)\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				}
				]
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"X998_0707 sensor histidine kinase\tK19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3]"
				},
				{
					"name":"X998_0706 DNA-binding response regulator\tK19078 graR; two-component system, OmpR family, response regulator protein GraR"
				},
				{
					"name":"X998_0910 dltA; D-alanine--poly(phosphoribitol) ligase\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				},
				{
					"name":"X998_0911 dltB; D-alanyl-lipoteichoic acid biosynthesis protein DltB\tK03739 dltB; membrane protein involved in D-alanine export"
				},
				{
					"name":"X998_0912 D-alanine--poly(phosphoribitol) ligase subunit 2\tK14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]"
				},
				{
					"name":"X998_0913 dltD; D-alanyl-lipoteichoic acid biosynthesis protein DltD\tK03740 dltD; D-alanine transfer protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"X998_0707 sensor histidine kinase\tK19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3]"
				},
				{
					"name":"X998_0706 DNA-binding response regulator\tK19078 graR; two-component system, OmpR family, response regulator protein GraR"
				},
				{
					"name":"X998_1368 mprF; phosphatidylglycerol lysyltransferase\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]",
				"children":[
				{
					"name":"X998_0707 sensor histidine kinase\tK19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3]"
				},
				{
					"name":"X998_0706 DNA-binding response regulator\tK19078 graR; two-component system, OmpR family, response regulator protein GraR"
				},
				{
					"name":"X998_0708 ABC transporter ATP-binding protein\tK19079 vraF; cationic antimicrobial peptide transport system ATP-binding protein"
				},
				{
					"name":"X998_0709 ABC transporter permease\tK19080 vraG; cationic antimicrobial peptide transport system permease protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]"
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]"
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]",
				"children":[
				{
					"name":"X998_0735 MarR family transcriptional regulator\tK18906 mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA"
				},
				{
					"name":"X998_0087 PLP-dependent aminotransferase family protein\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				},
				{
					"name":"X998_0691 ABC transporter ATP-binding protein\tK18104 abcA; ATP-binding cassette, subfamily B, bacterial AbcA\/BmrA [EC:7.6.2.2]"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]",
				"children":[
				{
					"name":"X998_0735 MarR family transcriptional regulator\tK18906 mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA"
				},
				{
					"name":"X998_0087 PLP-dependent aminotransferase family protein\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				},
				{
					"name":"X998_0083 MFS transporter\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				},
				{
					"name":"X998_1444 quinolone resistance protein NorB\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				},
				{
					"name":"X998_2429 MFS transporter\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]",
				"children":[
				{
					"name":"X998_0390 multidrug efflux MATE transporter transcriptional repressor MepR\tK18909 mepR; MarR family transcriptional regulator, repressor for mepA"
				},
				{
					"name":"X998_0391 mepA; multidrug efflux MATE transporter MepA\tK18908 mepA; MATE family, multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}