{
	"name":"sauq01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"SAI4T8_1006320 Nucleotidyltransferase domain protein\tK19279 ant9; aminoglycoside 9-adenylyltransferase [EC:2.7.7.-]"
				},
				{
					"name":"SAI4T8_1012010 Nucleotidyltransferase domain protein\tK19279 ant9; aminoglycoside 9-adenylyltransferase [EC:2.7.7.-]"
				},
				{
					"name":"SAI4T8_1015860 Nucleotidyltransferase domain protein\tK19279 ant9; aminoglycoside 9-adenylyltransferase [EC:2.7.7.-]"
				},
				{
					"name":"SAI4T8_1019360 Nucleotidyltransferase domain protein\tK19279 ant9; aminoglycoside 9-adenylyltransferase [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"SAI4T8_1000920 Probable membrane transport protein\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases",
				"children":[
				{
					"name":"SAI4T8_1006330 ermA; rRNA adenine N-6-methyltransferase\tK00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]"
				},
				{
					"name":"SAI4T8_1012000 ermA; rRNA adenine N-6-methyltransferase\tK00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]"
				},
				{
					"name":"SAI4T8_1015850 ermA; rRNA adenine N-6-methyltransferase\tK00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]"
				},
				{
					"name":"SAI4T8_1019350 ermA; rRNA adenine N-6-methyltransferase\tK00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]"
				}
				]
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"SAI4T8_1001110 capH; Capsular polysaccharide synthesis enzyme O-acetyl transferase Cap5H\tK00638 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"SAI4T8_20080 qacA; Antiseptic resistance protein\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]",
				"children":[
				{
					"name":"SAI4T8_1000280 mecR1; Methicillin-resistance regulatory protein MecR1\tK02547 mecR1; methicillin resistance protein"
				},
				{
					"name":"SAI4T8_1000270 mecA; Penicillin-binding protein 2 prime\tK02545 mecA; penicillin-binding protein 2 prime [EC:3.4.16.4]"
				}
				]
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"SAI4T8_20040 blaR1; Beta-lactamase regulatory protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"SAI4T8_20030 Beta-lactamase\tK18766 blaZ; beta-lactamase class A BlaZ [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]",
				"children":[
				{
					"name":"SAI4T8_1000920 Probable membrane transport protein\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				}
				]
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"SAI4T8_1005100 graS; Sensor histidine kinase graS\tK19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3]"
				},
				{
					"name":"SAI4T8_1005090 DNA-binding response regulator\tK19078 graR; two-component system, OmpR family, response regulator protein GraR"
				},
				{
					"name":"SAI4T8_1006540 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				},
				{
					"name":"SAI4T8_1006550 dltB; DltB membrane protein\tK03739 dltB; membrane protein involved in D-alanine export"
				},
				{
					"name":"SAI4T8_1006560 dltD; D-alanine lipoteichoic acid and wall teichoic acid esterification secreted protein\tK03740 dltD; D-alanine transfer protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"SAI4T8_1005100 graS; Sensor histidine kinase graS\tK19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3]"
				},
				{
					"name":"SAI4T8_1005090 DNA-binding response regulator\tK19078 graR; two-component system, OmpR family, response regulator protein GraR"
				},
				{
					"name":"SAI4T8_1009770 Putative uncharacterized protein\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]",
				"children":[
				{
					"name":"SAI4T8_1005100 graS; Sensor histidine kinase graS\tK19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3]"
				},
				{
					"name":"SAI4T8_1005090 DNA-binding response regulator\tK19078 graR; two-component system, OmpR family, response regulator protein GraR"
				},
				{
					"name":"SAI4T8_1005110 ABC transporter, ATP-binding protein\tK19079 vraF; cationic antimicrobial peptide transport system ATP-binding protein"
				},
				{
					"name":"SAI4T8_1005120 vraG; ABC transporter permease\tK19080 vraG; cationic antimicrobial peptide transport system permease protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]"
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]"
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]",
				"children":[
				{
					"name":"SAI4T8_1000640 GntR family transcriptional regulator\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				},
				{
					"name":"SAI4T8_1004960 abcA; ABC superfamily ATP binding cassette transporter,ABC protein\tK18104 abcA; ATP-binding cassette, subfamily B, bacterial AbcA\/BmrA [EC:7.6.2.2]"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]",
				"children":[
				{
					"name":"SAI4T8_1000640 GntR family transcriptional regulator\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				},
				{
					"name":"SAI4T8_1000600 Similar to Blt-like protein\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				},
				{
					"name":"SAI4T8_1010370 Major Facilitator Superfamily protein\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				},
				{
					"name":"SAI4T8_1018180 Integral membrane efflux protein\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"SAI4T8_20070 qacR; HTH-type transcriptional regulator QacR\tK18938 qacR; TetR\/AcrR family transcriptional regulator, repressor for qacA"
				},
				{
					"name":"SAI4T8_20080 qacA; Antiseptic resistance protein\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]",
				"children":[
				{
					"name":"SAI4T8_1002560 MATE efflux family protein\tK18908 mepA; MATE family, multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}