{
	"name":"sbp01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]",
				"children":[
				{
					"name":"Sbal223_0838 Beta-lactamase\tK22332 blaOXA-548; beta-lactamase class D OXA-548 [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"Sbal223_1513 Na+\/H+ antiporter NhaC\tK18218 tet35; tetracycline resistance efflux pump"
				},
				{
					"name":"Sbal223_2247 Na+\/H+ antiporter NhaC\tK18218 tet35; tetracycline resistance efflux pump"
				},
				{
					"name":"Sbal223_3955 Na+\/H+ antiporter NhaC\tK18218 tet35; tetracycline resistance efflux pump"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"Sbal223_2780 transferase hexapeptide repeat containing protein\tK18234 vat; virginiamycin A acetyltransferase [EC:2.3.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"Sbal223_4157 Chloramphenicol O-acetyltransferase\tK00638 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"Sbal223_3500 histidine kinase\tK18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"Sbal223_1675 protein of unknown function DUF470\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"Sbal223_1849 histidine kinase\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"Sbal223_4141 histidine kinase\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"Sbal223_1850 two component transcriptional regulator, winged helix family\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				},
				{
					"name":"Sbal223_4140 two component transcriptional regulator, winged helix family\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"Sbal223_0650 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Sbal223_1201 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Sbal223_1584 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Sbal223_1796 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Sbal223_1830 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Sbal223_4212 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Sbal223_0651 acriflavin resistance protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"Sbal223_1200 acriflavin resistance protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"Sbal223_1583 acriflavin resistance protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"Sbal223_1797 acriflavin resistance protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"Sbal223_1829 acriflavin resistance protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"Sbal223_4211 transporter, hydrophobe\/amphiphile efflux-1 (HAE1) family\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"Sbal223_0827 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]",
				"children":[
				{
					"name":"Sbal223_1187 efflux transporter, RND family, MFP subunit\tK18298 mexE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"Sbal223_1188 transporter, hydrophobe\/amphiphile efflux-1 (HAE1) family\tK18299 mexF; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"Sbal223_1391 transcriptional regulator, TetR family\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"Sbal223_0827 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"Sbal223_0827 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"Sbal223_2847 transcriptional regulator, MerR family\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"Sbal223_0530 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"Sbal223_0806 type I secretion outer membrane protein, TolC family\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"Sbal223_0174 two component transcriptional regulator, LuxR family\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"Sbal223_0530 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"Sbal223_0806 type I secretion outer membrane protein, TolC family\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]",
				"children":[
				{
					"name":"Sbal223_2723 porin Gram-negative type\tK09476 ompF; outer membrane pore protein F"
				}
				]
			}
			]
		}
		]
	}
	]
}