{
	"name":"scac03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"106081099 activating signal cointegrator 1 complex subunit 3\tK18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]"
				},
				{
					"name":"106080972 deoxyribodipyrimidine photo-lyase isoform X1\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"106080596 single-strand selective monofunctional uracil DNA glycosylase\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"106082626 N-glycosylase\/DNA lyase isoform X1\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"106083395 endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"106089977 DNA polymerase delta catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"106087498 DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"106085836 DNA polymerase delta subunit 3\tK03504 POLD3; DNA polymerase delta subunit 3"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"106085578 DNA polymerase epsilon catalytic subunit 1 isoform X1\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"106090797 DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"106094131 DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						},
						{
							"name":"106080913 DNA polymerase epsilon subunit 4\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"106081394 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"106087297 flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors",
					"children":[
					{
						"name":"106086392 DNA repair protein XRCC1\tK10803 XRCC1; DNA-repair protein XRCC1"
					},
					{
						"name":"106083111 DNA ligase 3\tK10776 LIG3; DNA ligase 3 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"106082439 probable tyrosyl-DNA phosphodiesterase\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"106087202 aprataxin-like protein isoform X1\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"106085581 uncharacterized protein F21D5.5\tK08073 PNKP; bifunctional polynucleotide phosphatase\/kinase [EC:3.1.3.32 2.7.1.78]"
					},
					{
						"name":"106090270 poly [ADP-ribose] polymerase\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"106085040 DNA repair protein complementing XP-C cells homolog isoform X1\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"106082003 UV excision repair protein RAD23 homolog B\tK10839 RAD23; UV excision repair protein RAD23"
						},
						{
							"name":"106082005 UV excision repair protein RAD23 homolog A\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"106096045 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"106091878 cullin-4A\tK10609 CUL4; cullin 4"
						},
						{
							"name":"106089454 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"106080855 DNA-directed RNA polymerase II subunit RPB1\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"106096251 DNA-directed RNA polymerase II subunit RPB2\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"106080900 DNA-directed RNA polymerase II subunit RPB3\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"106080396 transcriptional adapter 2A isoform X1\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"106083854 DNA-directed RNA polymerases I, II, and III subunit RPABC1\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"106085813 DNA-directed RNA polymerases I, II, and III subunit RPABC2\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"106089240 DNA-directed RNA polymerase II subunit RPB7\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"106096153 DNA-directed RNA polymerases I, II, and III subunit RPABC3\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"106092845 DNA-directed RNA polymerase II subunit RPB9\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"106084507 DNA-directed RNA polymerases I, II, and III subunit RPABC5\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"106095557 DNA-directed RNA polymerase II subunit RPB11\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"106082351 DNA-directed RNA polymerases I, II, and III subunit RPABC4\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"106096045 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"106091878 cullin-4A\tK10609 CUL4; cullin 4"
						},
						{
							"name":"106089454 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"106094238 transcription elongation factor 1 homolog\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"106087387 general transcription and DNA repair factor IIH helicase subunit XPB\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"106082338 general transcription and DNA repair factor IIH helicase subunit XPD\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"106082641 general transcription factor IIH subunit 1\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"106089785 general transcription factor IIH subunit 2\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"106087656 general transcription factor IIH subunit 3\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"106094045 general transcription factor IIH subunit 4\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"106082302 general transcription factor IIH subunit 5\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"106087544 cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"131997733 cyclin-H-like\tK06634 CCNH; cyclin H"
					},
					{
						"name":"106080699 CDK-activating kinase assembly factor MAT1\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"106088734 replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"106080585 replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"106089162 uncharacterized protein LOC106089162\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"106086685 DNA repair protein complementing XP-A cells homolog\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"106087642 DNA excision repair protein ERCC-1\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"106091920 DNA repair endonuclease XPF\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"106094214 DNA excision repair protein ERCC-5 homolog isoform X1\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"106081443 MMS19 nucleotide excision repair protein\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"106087641 probable cytosolic iron-sulfur protein assembly protein Ciao1\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"106083498 MIP18 family protein galla-1\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"106086627 MIP18 family protein galla-2\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"106095486 cullin-3 isoform X1\tK03869 CUL3; cullin 3"
					},
					{
						"name":"106081651 cullin-5\tK10612 CUL5; cullin 5"
					},
					{
						"name":"106087309 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"106090867 elongin-B\tK03873 ELOB; elongin-B"
					},
					{
						"name":"106082802 transcription elongation factor B polypeptide 3\tK15076 ELOA; elongin-A"
					},
					{
						"name":"106091704 protein lingerer isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"106082040 DNA mismatch repair protein spellchecker 1\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"106092423 DNA mismatch repair protein spellchecker 1\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"106095142 probable DNA mismatch repair protein Msh6\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"106090131 DNA mismatch repair protein Mlh1\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"106081916 mismatch repair endonuclease PMS2\tK10858 PMS2; DNA mismatch repair protein PMS2"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"106089977 DNA polymerase delta catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"106087498 DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"106085836 DNA polymerase delta subunit 3\tK03504 POLD3; DNA polymerase delta subunit 3"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"106088734 replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"106080585 replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"106089162 uncharacterized protein LOC106089162\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"106095617 replication factor C subunit 1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"106085540 replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"106088976 replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"106083851 replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"106086886 replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"106081394 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"106090331 exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"106083948 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"106091600 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"106090916 nibrin\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex",
					"children":[
					{
						"name":"106085111 DNA topoisomerase 2-binding protein 1\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
					}
					]
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"106083948 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"106091600 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"106090916 nibrin\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"106086735 DNA repair protein RAD51 homolog A\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"106086735 DNA repair protein RAD51 homolog A\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"106096362 DNA repair protein RAD51 homolog 3\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"106082321 DNA repair protein RAD51 homolog 4\tK10871 RAD51L3; RAD51-like protein 3"
					},
					{
						"name":"106086410 DNA repair protein XRCC3 isoform X1\tK10880 XRCC3; DNA-repair protein XRCC3"
					}
					]
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"106086325 DNA repair and recombination protein RAD54-like\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"106083436 helicase ARIP4\tK10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"106086389 bifunctional 3'-5' exonuclease\/ATP-dependent helicase WRN\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
					},
					{
						"name":"106088667 recQ-like DNA helicase Blm\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"106091083 uncharacterized protein LOC106091083\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
					},
					{
						"name":"106089150 ATP-dependent DNA helicase Q5\tK10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"106088667 recQ-like DNA helicase Blm\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"106083365 DNA topoisomerase 3-alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"106087111 DNA topoisomerase 3-beta\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"106088734 replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"106080585 replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"106089162 uncharacterized protein LOC106089162\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"106084292 serine\/threonine-protein phosphatase 4 catalytic subunit\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"106084221 serine\/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1\tK15425 PPP4R2; serine\/threonine-protein phosphatase 4 regulatory subunit 2"
					},
					{
						"name":"106095794 serine\/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"106091973 structural maintenance of chromosomes protein 5\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"106087659 structural maintenance of chromosomes protein 6\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"106089205 non-structural maintenance of chromosomes element 1 homolog\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"106083585 melanoma-associated antigen D2\tK22823 NSMCE3; non-structural maintenance of chromosomes element 3"
					},
					{
						"name":"106088802 EP300-interacting inhibitor of differentiation 3\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"106081028 uncharacterized protein LOC106081028\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"106081622 exonuclease 3'-5' domain-containing protein 2\tK20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]"
					},
					{
						"name":"106092785 crossover junction endonuclease MUS81\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"106093625 DNA repair protein SWI5 homolog\tK10991 SWI5; DNA repair protein Swi5\/Sae3"
					},
					{
						"name":"106094679 structure-specific endonuclease subunit SLX1 homolog\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"106082371 flap endonuclease GEN\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"106084269 uncharacterized protein LOC106084269\tK19026 SPG11; spatacsin"
					},
					{
						"name":"106080412 zinc finger FYVE domain-containing protein 26 homolog\tK19027 ZFYVE26; zinc finger FYVE domain-containing protein 26"
					},
					{
						"name":"106095604 nuA4 complex subunit EAF3 homolog\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"106094231 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1\tK22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"
					},
					{
						"name":"106085855 fidgetin-like protein 1 isoform X1\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"106086048 uncharacterized protein LOC106086048\tK23112 BRAT1; BRCA1-associated ATM activator 1"
					},
					{
						"name":"106087168 myosin-G heavy chain isoform X4\tK23456 CFAP410; cilla- and flagella-associated protein"
					},
					{
						"name":"106084053 serine-rich adhesin for platelets isoform X1\tK25790 EMSY; BRCA2-interacting transcriptional repressor EMSY"
					},
					{
						"name":"106087909 protein MMS22-like\tK26125 MMS22L; protein MMS22-like"
					},
					{
						"name":"106087786 tonsoku-like protein isoform X2\tK09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2"
					},
					{
						"name":"106092201 3'-5' exonuclease\tK22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"106088232 ATP-dependent DNA helicase 2 subunit 1\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"106092749 X-ray repair cross-complementing protein 5\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"106083948 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"106091600 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"106085900 DNA ligase 4\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"106087202 aprataxin-like protein isoform X1\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex",
					"children":[
					{
						"name":"106090856 E3 ubiquitin-protein ligase FANCL\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
					},
					{
						"name":"131994759 E3 ubiquitin-protein ligase FANCL-like\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
					},
					{
						"name":"106083252 uncharacterized protein LOC106083252\tK10896 FANCM; fanconi anemia group M protein"
					}
					]
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"106087724 ubiquitin-conjugating enzyme E2 D2B-like\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"106088667 recQ-like DNA helicase Blm\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"106083365 DNA topoisomerase 3-alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"106087111 DNA topoisomerase 3-beta\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					}
					]
				},
				{
					"name":"FANCD2-I complex",
					"children":[
					{
						"name":"106082973 Fanconi anemia group D2 protein homolog\tK10891 FANCD2; fanconi anemia group D2 protein"
					},
					{
						"name":"106080710 Fanconi anemia group I protein\tK10895 FANCI; fanconi anemia group I protein"
					}
					]
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"106086735 DNA repair protein RAD51 homolog A\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"106096362 DNA repair protein RAD51 homolog 3\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"106092896 serine-rich adhesin for platelets\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
					},
					{
						"name":"106092990 WD repeat-containing protein 48 homolog\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6",
					"children":[
					{
						"name":"106085223 serine\/threonine-protein phosphatase 6 catalytic subunit\tK15498 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"106089050 serine\/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1\tK15501 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3"
					}
					]
				},
				{
					"name":"Ubiquitin ligases",
					"children":[
					{
						"name":"106085523 LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC2\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"106094683 telomerase Cajal body protein 1 homolog\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"106080836 gastrulation defective protein 1 homolog\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"106083586 abasic site processing protein HMCES\tK28434 HMCES; abasic site processing protein HMCES"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"106090745 DNA polymerase eta isoform X1\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"106095803 DNA polymerase iota isoform X1\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"106092125 DNA repair protein Rev1\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"106086681 DNA polymerase zeta catalytic subunit\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"106084799 ubiquitin-conjugating enzyme E2-17 kDa\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"106090484 ubiquitin-conjugating enzyme E2 variant 1 isoform X2\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"106085301 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"106081394 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"106085032 uncharacterized protein LOC106085032\tK24051 SPRTN; SprT-like domain-contaning protein Spartan"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"106090207 cell cycle checkpoint control protein RAD9A\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"106090268 checkpoint protein HUS1 isoform X1\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"106084986 cell cycle checkpoint protein RAD1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"106086893 cell cycle checkpoint protein RAD17\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"106085540 replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106088976 replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"106083851 replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"106086886 replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"106084986 cell cycle checkpoint protein RAD1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"106082285 protein timeless homolog\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"106092079 protein TIPIN homolog\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"106094777 claspin\tK25773 CLSPN; claspin"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"106085574 TELO2-interacting protein 1 homolog\tK20403 TTI1; TELO2-interacting protein 1"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"106082518 large proline-rich protein bag6-A isoform X1\tK23390 BAG6; large proline-rich protein BAG6"
				},
				{
					"name":"106091006 ubiquitin-like protein 4A\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"106087180 Golgi to ER traffic protein 4 homolog\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex",
				"children":[
				{
					"name":"106080902 integrator complex subunit 3 homolog\tK13140 INTS3; integrator complex subunit 3 (SOSS complex subunit A)"
				},
				{
					"name":"106088625 SOSS complex subunit B homolog\tK28889 NABP; SOSS complex subunit B"
				},
				{
					"name":"131994083 SOSS complex subunit C homolog isoform X1\tK28890 INIP; SOSS complex subunit C"
				}
				]
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"106086305 serine\/threonine-protein kinase ATM\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"106082767 serine\/threonine-protein kinase grp\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"106083079 ovarian-specific serine\/threonine-protein kinase Lok isoform X1\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"106080611 M-phase inducer phosphatase isoform X2\tK05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]"
				},
				{
					"name":"106085393 14-3-3 protein zeta isoform X1\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"106089236 14-3-3 protein epsilon\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"106088247 protein sickie isoform X1\tK19483 NAV2; neuron navigator 2 [EC:5.6.2.4]"
				},
				{
					"name":"106083542 wee1-like protein kinase\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"106082624 period circadian protein isoform X1\tK02633 PER2; period circadian protein 2"
				},
				{
					"name":"106095892 plastin-3 isoform X1\tK17336 PLS3; plastin-3"
				},
				{
					"name":"106085809 protein downstream neighbor of son homolog isoform X1\tK22422 DONSON; protein downstream neighbor of Son"
				},
				{
					"name":"106083656 KN motif and ankyrin repeat domain-containing protein 2 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"106088796 vacuolar protein sorting-associated protein 4\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"106086813 abscission\/NoCut checkpoint regulator\tK24778 ZFYVE19; abscission\/NoCut checkpoint regulator"
				},
				{
					"name":"106089313 splicing regulator SDE2\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"106089877 bladder cancer-associated protein\tK29062 BLCAP; apoptosis inducing factor BLCAP"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"106093117 myb-binding protein 1A\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"106082054 uncharacterized protein LOC106082054 isoform X1\tK10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]"
				},
				{
					"name":"106086324 uncharacterized protein LOC106086324\tK10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]"
				},
				{
					"name":"106088477 three prime repair exonuclease 2\tK10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]"
				},
				{
					"name":"106085850 uncharacterized protein LOC106085850\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"106085541 uncharacterized protein LOC106085541\tK21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"106086472 helicase POLQ-like\tK19178 HELQ; POLQ-like helicase [EC:5.6.2.4]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"106092806 pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"106086628 cell division cycle 5-like protein\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"106095014 pre-mRNA-splicing factor SPF27\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"106095341 pleiotropic regulator 1\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"106081600 8-oxo-dGDP phosphatase NUDT18\tK17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]"
				},
				{
					"name":"106085852 deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"106087103 uncharacterized protein LOC106087103\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"106091606 ribonucleoside-diphosphate reductase large subunit\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"106085380 ribonucleoside-diphosphate reductase subunit M2\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"106080972 deoxyribodipyrimidine photo-lyase isoform X1\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"106080596 single-strand selective monofunctional uracil DNA glycosylase\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"106083395 endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors"
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"106081589 single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"106081589 single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"106085852 deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"106087103 uncharacterized protein LOC106087103\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}