{
	"name":"scyc01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"AB1723_04570 aminoglycoside phosphotransferase family protein\tK18844 aph; spectinomycin phosphotransferase"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"AB1723_06595 MFS transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"AB1723_10900 TonB family protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"AB1723_15835 M56 family metallopeptidase\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"AB1723_10905 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"AB1723_10465 blaL2; (GenBank) L2 family extended-spectrum class A beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"AB1723_01600 M15 family metallopeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"AB1723_17360 M15 family metallopeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"AB1723_09435 mprF; (GenBank) bifunctional lysylphosphatidylglycerol flippase\/synthetase MprF\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"AB1723_16620 sensor histidine kinase\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"AB1723_16615 response regulator transcription factor\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"AB1723_04280 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AB1723_07695 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AB1723_10815 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AB1723_12085 smeD; (GenBank) multidrug efflux RND transporter periplasmic adaptor subunit SmeD\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AB1723_04285 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AB1723_07700 multidrug efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AB1723_10810 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AB1723_12080 smeE; (GenBank) multidrug efflux RND transporter permease subunit SmeE\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AB1723_02580 emrC; (GenBank) multidrug efflux transporter outer membrane subunit EmrC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AB1723_02635 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AB1723_12075 smeF; (GenBank) multidrug efflux RND transporter outer membrane subunit SmeF\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]",
				"children":[
				{
					"name":"AB1723_03935 efflux transporter outer membrane subunit\tK18300 oprN; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"AB1723_11460 TetR\/AcrR family transcriptional regulator\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"AB1723_11455 efflux RND transporter periplasmic adaptor subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AB1723_11450 efflux RND transporter permease subunit\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"AB1723_02580 emrC; (GenBank) multidrug efflux transporter outer membrane subunit EmrC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AB1723_02635 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AB1723_12075 smeF; (GenBank) multidrug efflux RND transporter outer membrane subunit SmeF\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"AB1723_02580 emrC; (GenBank) multidrug efflux transporter outer membrane subunit EmrC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AB1723_02635 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AB1723_12075 smeF; (GenBank) multidrug efflux RND transporter outer membrane subunit SmeF\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"AB1723_07005 heavy metal-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"AB1723_02090 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AB1723_11470 TolC family outer membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"AB1723_02090 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AB1723_11470 TolC family outer membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"AB1723_14705 LysR substrate-binding domain-containing protein\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}