{
	"name":"send03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors"
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex"
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex"
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors"
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex"
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex"
				},
				{
					"name":"Ran-mediated transport factors"
				},
				{
					"name":"eIF4F and regulatory proteins"
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors"
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex"
				},
				{
					"name":"Protein phosphatase 2A"
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins"
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule"
				},
				{
					"name":"P-body specific factors"
				},
				{
					"name":"Stress granule specific factors"
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex"
				},
				{
					"name":"Lsm complex"
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors"
				},
				{
					"name":"Exosome cofactors"
				},
				{
					"name":"TRAMP complex"
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex"
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"DT104_11641 ams; ribonuclease E\tK08300 rne; ribonuclease E [EC:3.1.26.12]"
					},
					{
						"name":"DT104_33621 rnG; ribonuclease G\tK08301 rng; ribonuclease G [EC:3.1.26.-]"
					},
					{
						"name":"DT104_26321 rnc; Ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"DT104_43561 rnr; ribonuclease R (RNase R)\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
					},
					{
						"name":"DT104_43421 orn; oligoribonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"DT104_39331 rhlB; putative ATP-dependent RNA helicase\tK03732 rhlB; ATP-dependent RNA helicase RhlB [EC:5.6.2.7]"
					},
					{
						"name":"DT104_08361 rhlE; putative ATP-dependent RNA helicase rhlE\tK11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]"
					},
					{
						"name":"DT104_32751 ATP-dependent RNA helicase (dead-box protein)\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
					},
					{
						"name":"DT104_39721 recQ; ATP-dependent DNA helicase\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"DT104_29501 eno; Enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"DT104_32771 pnp; polynucleotide phosphorylase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"DT104_39351 rho; transcription termination factor\tK03628 rho; transcription termination factor Rho"
					},
					{
						"name":"DT104_40711 pfkA; 6-phosphofructokinase\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"DT104_00111 dnaK; DnaK protein (heat shock protein 70)\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"DT104_43231 groEL; GroEL protein\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"DT104_43501 hfQ; host factor-I protein(HF-I)\tK03666 hfq; host factor-I protein"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"DT104_25531 ppk; Polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]"
					},
					{
						"name":"DT104_01891 pcnB; poly(A) polymerase\tK00970 pcnB; poly(A) polymerase [EC:2.7.7.19]"
					},
					{
						"name":"DT104_30001 nudH; dinucleoside polyphosphate hydrolase\tK08311 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]"
					},
					{
						"name":"DT104_28231 csrA; Carbon storage regulator homolog.\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"DT104_33671 yhdA; putative lipoprotein\tK18765 csrD; RNase E specificity factor CsrD"
					},
					{
						"name":"DT104_40981 menG; menaquinone biosynthesis protein\tK02553 rraA; regulator of ribonuclease activity A"
					},
					{
						"name":"DT104_44601 conserved hypothetical protein\tK09893 rraB; regulator of ribonuclease activity B"
					},
					{
						"name":"DT104_33161 conserved hypothetical protein\tK06958 rapZ; RNase adapter protein RapZ"
					},
					{
						"name":"DT104_16121 hrpA; ATP-dependent helicase HrpA\tK03578 hrpA; ATP-dependent RNA helicase HrpA [EC:5.6.2.6]"
					},
					{
						"name":"DT104_01941 hrpB; ATP-dependent helicase HrpB\tK03579 hrpB; ATP-dependent RNA helicase HrpB [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome"
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}