{
	"name":"serf02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins"
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"L085_04925 type I site-specific deoxyribonuclease, HsdR family protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"L085_04910 type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"L085_03045 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"L085_01560 hypothetical protein\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok",
				"children":[
				{
					"name":"L085_11775 Hok\/gef cell toxic protein\tK18920 hokA; protein HokA"
				},
				{
					"name":"L085_08080 hypothetical protein\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"L085_08100 hypothetical protein\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"L085_24065 hypothetical protein\tK18919 hokC_D; protein HokC\/D"
				}
				]
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"L085_07610 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"L085_11095 transcriptional regulatory protein\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"L085_15655 DNA-binding transcriptional activator PspC\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"L085_15650 pspB; phage shock protein B\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"L085_20805 toxin of gyrase inhibiting toxin-antitoxin system\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"L085_20810 post-segregation antitoxin CcdA\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"L085_10765 phage\/plasmid maintenance toxin\/antidote system protein (toxin)\tK07341 doc; death on curing protein"
				},
				{
					"name":"L085_10760 phage\/plasmid maintenance toxin\/antidote system protein (antidote)\tK19165 phd; antitoxin Phd"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"L085_06840 plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"L085_06835 putative DNA-binding transcriptional regulator\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"L085_10265 PilT domain-containing protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"L085_10260 SpoVT\/AbrB domain-containing protein\tK18829 mvpT; antitoxin VapB"
				},
				{
					"name":"L085_23585 PilT domain-containing protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"L085_23590 prevent-host-death family protein\tK28280 vapB22; antitoxin VapB22"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"L085_03130 PilT domain-containing protein\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"L085_03125 putative plasmid stability-like protein\tK21495 fitA; antitoxin FitA"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"L085_19255 bssS; biofilm formation regulatory protein BssS\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"L085_21595 hypothetical protein\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"L085_21600 hypothetical protein\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"L085_00495 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"L085_06360 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"L085_07080 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"L085_07060 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"L085_10990 gltX; glutamyl-tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"L085_04970 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"L085_22760 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"L085_04965 hypothetical protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				},
				{
					"name":"L085_22765 hypothetical protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"L085_08480 hypothetical protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"L085_08475 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein",
				"children":[
				{
					"name":"L085_15070 hypothetical protein\tK28274 ortT; orphan toxin OrtT"
				}
				]
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"L085_23265 gene expression modulator\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"L085_23260 Hha toxicity attenuator\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"L085_09960 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}