{
	"name":"setc02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"CFSAN001921_02385 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"CFSAN001921_02390 ssRNA endonuclease\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors",
				"children":[
				{
					"name":"CFSAN001921_02360 CRISPR-associated protein CasA\tK19123 casA; CRISPR system Cascade subunit CasA"
				},
				{
					"name":"CFSAN001921_02365 transposase\tK19046 casB; CRISPR system Cascade subunit CasB"
				},
				{
					"name":"CFSAN001921_02370 CRISPR-associated protein Cse4\tK19124 casC; CRISPR system Cascade subunit CasC"
				},
				{
					"name":"CFSAN001921_02375 cytoplasmic protein\tK19125 casD; CRISPR system Cascade subunit CasD"
				},
				{
					"name":"CFSAN001921_02380 CRISPR-associated protein Cas6\tK19126 casE; CRISPR system Cascade subunit CasE"
				}
				]
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"CFSAN001921_17795 hypothetical protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"CFSAN001921_17805 type I restriction endonuclease StySJI subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"CFSAN001921_17800 SAM-dependent methyltransferase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"CFSAN001921_23025 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"CFSAN001921_00055 methyltransferase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"CFSAN001921_07110 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"CFSAN001921_24070 DNA methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"CFSAN001921_03525 type III restriction enzyme, res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"CFSAN001921_15250 type III restriction endonuclease StyLTI\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"CFSAN001921_15255 type III restriction endonuclease StyLTI\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"CFSAN001921_06935 endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"CFSAN001921_17790 restriction endonuclease\tK07448 mrr; restriction system protein"
			},
			{
				"name":"CFSAN001921_17980 restriction endonuclease\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"CFSAN001921_15920 hypothetical protein\tK19048 symE; toxic protein SymE"
				},
				{
					"name":"CFSAN001921_17810 endoribonuclease SymE\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl",
				"children":[
				{
					"name":"CFSAN001921_14975 Toxic polypeptide, small\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"CFSAN001921_22325 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				}
				]
			},
			{
				"name":"TisB-IstR",
				"children":[
				{
					"name":"CFSAN001921_21455 hypothetical protein\tK19148 tisB; small toxic protein TisB"
				}
				]
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"CFSAN001921_09370 RelE toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"CFSAN001921_18165 RelE toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"CFSAN001921_18170 bifunctional antitoxin\/transcriptional repressor RelB\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				},
				{
					"name":"CFSAN001921_09365 plasmid stabilization protein\tK18923 stbD; antitoxin StbD"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"CFSAN001921_22860 antitoxin\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"CFSAN001921_08650 transcriptional regulator\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"CFSAN001921_08645 pspB; phage-shock protein\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"CFSAN001921_02300 plasmid stabilization protein ParE\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"CFSAN001921_02295 hypothetical protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"CFSAN001921_22655 hypothetical protein\tK07341 doc; death on curing protein"
				},
				{
					"name":"CFSAN001921_22650 antitoxin\tK19165 phd; antitoxin Phd"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"CFSAN001921_20285 cytoplasmic protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"CFSAN001921_20290 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"CFSAN001921_01880 pirin\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"CFSAN001921_01875 hypothetical protein\tK18829 mvpT; antitoxin VapB"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"CFSAN001921_18085 Toxin-antitoxin biofilm protein TabA\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"CFSAN001921_11370 bssS; biofilm formation regulatory protein BssS\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"CFSAN001921_12740 biofilm formation regulatory protein BssR\tK19688 bssR; biofilm regulator BssR"
				},
				{
					"name":"CFSAN001921_11105 multiple stress resistance protein BhsA\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"CFSAN001921_16755 peptidase M23\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"CFSAN001921_00115 rod shape-determining protein Mbl\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"CFSAN001921_01140 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"CFSAN001921_01105 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"CFSAN001921_04700 gltX; glutaminyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"CFSAN001921_03445 toxin of the YeeV-YeeU toxin-antitoxin system\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"CFSAN001921_03455 antitoxin YeeU\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"CFSAN001921_01810 membrane protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"CFSAN001921_01805 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein",
				"children":[
				{
					"name":"CFSAN001921_09120 hypothetical protein\tK28274 ortT; orphan toxin OrtT"
				}
				]
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"CFSAN001921_14670 gene expression modulator\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"CFSAN001921_14665 Hha toxicity attenuator\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"CFSAN001921_04055 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"CFSAN001921_24380 phosphoadenosine phosphosulfate reductase\tK19170 dndC; DNA sulfur modification protein DndC"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}