{
	"name":"sfd02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"USDA257_c01230 phoR1; alkaline phosphatase synthesis sensor protein PhoR\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c01290 phoB1; phosphate regulon transcriptional regulatory protein PhoB\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			},
			{
				"name":"USDA257_c29560 putative response regulator of two-component system\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			},
			{
				"name":"USDA257_c29570 phoB2; phosphate regulon transcriptional regulatory protein PhoB\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"USDA257_c46660 envZ; osmolarity sensor protein EnvZ\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c46650 petR; protein PetR\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"USDA257_c01150 kdpD1; sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c09580 kdpD2; sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c09590 kdpE; transcriptional regulatory protein KdpE\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)",
			"children":[
			{
				"name":"USDA257_c15270 Two component sensor kinase\tK07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c15280 qseB2; transcriptional regulatory protein QseB\tK07774 tctD; two-component system, OmpR family, response regulator TctD"
			}
			]
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)",
			"children":[
			{
				"name":"USDA257_c26600 Two-component sensor histidine kinase\tK14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c59040 chvG; sensor protein ChvG\tK14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c59060 chvI; transcriptional regulatory protein ChvI\tK14981 chvI; two-component system, OmpR family, response regulator ChvI"
			}
			]
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"USDA257_c03270 ftcR; flagellar transcriptional regulator FtcR\tK21603 ftcR; two-component system, OmpR family, flagellar system response regulator FtcR"
			},
			{
				"name":"USDA257_c07470 qseB1; transcriptional regulatory protein QseB\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c07560 cusR; transcriptional regulatory protein CusR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c11230 putative transcriptional regulatory protein y4xI\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c19990 copR1; transcriptional activator protein CopR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c20610 copR2; transcriptional activator protein CopR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c24130 czcR; transcriptional activator protein CzcR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c26610 resD; transcriptional regulatory protein ResD\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c39530 ompR2; transcriptional regulatory protein OmpR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c60720 ompR3; transcriptional regulatory protein OmpR\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"USDA257_c61300 qseB3; transcriptional regulatory protein QseB\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)",
			"children":[
			{
				"name":"USDA257_c10830 Two component transcriptional regulator, LuxR family\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			},
			{
				"name":"USDA257_c26300 degU; transcriptional regulatory protein DegU\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			},
			{
				"name":"USDA257_c26960 narP; nitrate\/nitrite response regulator protein NarP\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			}
			]
		},
		{
			"name":"NarQ-NarP (nitrate respiration)",
			"children":[
			{
				"name":"USDA257_c22050 sgaR; putative transcriptional regulatory protein SgaR\tK07685 narP; two-component system, NarL family, nitrate\/nitrite response regulator NarP"
			}
			]
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)"
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"USDA257_c34960 ntrB; nitrogen regulation protein NtrB\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c34970 ntrC; nitrogen assimilation regulatory protein\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)",
			"children":[
			{
				"name":"USDA257_c34980 ntrY; nitrogen regulation protein NtrY\tK13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c34990 ntrX; nitrogen assimilation regulatory protein NtrX\tK13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX"
			}
			]
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"USDA257_c11120 dctB1; C4-dicarboxylate transport sensor protein DctB\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c23220 dctB2; C4-dicarboxylate transport sensor protein DctB\tK10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c11100 dctD1; C4-dicarboxylate transport transcriptional regulatory protein DctD\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			},
			{
				"name":"USDA257_c23210 dctD2; C4-dicarboxylate transport transcriptional regulatory protein DctD\tK10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD"
			}
			]
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"USDA257_c02860 cheA; chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c30170 frzE; gliding motility regulatory protein FrzE\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c02850 putative two-component response regulator receiver protein\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"USDA257_c02900 cheY; putative chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"USDA257_c51790 putative two-component response regulator protein\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"USDA257_c02890 cheB1; chemotaxis response regulator protein-glutamate methylesterase of group 1 operon\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"USDA257_c30180 cheB2; chemotaxis response regulator protein-glutamate methylesterase of group 3 operon\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"USDA257_c60160 cheB3; chemotaxis response regulator protein-glutamate methylesterase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)",
			"children":[
			{
				"name":"USDA257_c07590 pleC2; Non-motile and phage-resistance protein PleC\tK07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c41550 pleC3; Non-motile and phage-resistance protein PleC\tK07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c07330 putative sensor-like histidine kinase R01002\tK11357 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c33300 pleD2; response regulator PleD\tK02488 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65]"
			},
			{
				"name":"USDA257_c33290 divK; polar-differentiation response regulator DivK\tK11443 divK; two-component system, cell cycle response regulator DivK"
			}
			]
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)",
			"children":[
			{
				"name":"USDA257_c40760 blue-light-activated protein\tK13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c51780 ctrA2; cell cycle response regulator CtrA\tK13584 ctrA; two-component system, cell cycle response regulator CtrA"
			},
			{
				"name":"USDA257_c52880 single domain response regulator\tK13589 cpdR; two-component system, cell cycle response regulator CpdR"
			}
			]
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)",
			"children":[
			{
				"name":"USDA257_c38920 fixL; sensor protein FixL\tK14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c38930 fixJ; transcriptional regulatory protein FixJ\tK14987 fixJ; two-component system, LuxR family, response regulator FixJ"
			}
			]
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)",
			"children":[
			{
				"name":"USDA257_c59290 regB; sensor histidine kinase RegB\tK15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c59280 actR; acid tolerance regulatory protein ActR\tK15012 regA; two-component system, response regulator RegA"
			}
			]
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)",
			"children":[
			{
				"name":"USDA257_c25980 putative sensor histidine kinase protein\tK20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]"
			},
			{
				"name":"USDA257_c30880 putative two-component response regulator receiver\tK20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"PdtaS-PdtaR",
			"children":[
			{
				"name":"USDA257_c19790 response regulator receiver protein\tK22010 pdtaR; two-component system, response regulator PdtaR"
			}
			]
		},
		{
			"name":"NasS-NasT",
			"children":[
			{
				"name":"USDA257_c30840 nrtC; nitrate transport ATP-binding protein NrtC\tK22067 nasS; two-component system, oxyanion-binding sensor"
			},
			{
				"name":"USDA257_c30850 Two-component response regulator protein\tK07183 nasT; two-component system, response regulator \/ RNA-binding antiterminator"
			}
			]
		},
		{
			"name":"Unclassified"
		}
		]
	}
	]
}