{
	"name":"sfd03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P"
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"USDA257_c08970 putative ribonuclease T2 family protein\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				},
				{
					"name":"USDA257_c45260 putative ribonuclease\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex"
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"USDA257_c53750 gltX; glutamate--tRNA ligase GltX\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"USDA257_c33170 proS; proline--tRNA ligase ProS\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"USDA257_c05130 ileS; isoleucine--tRNA ligase IleS\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"USDA257_c58490 leuS; leucine--tRNA ligase LeuS\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"USDA257_c40380 metG; methionine--tRNA ligase MetG\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"USDA257_c35620 argS; arginine--tRNA ligase ArgS\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"USDA257_c53760 lysS; lysine--tRNA ligase LysS\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"USDA257_c09140 aspS; aspartate--tRNA ligase AspS\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"USDA257_c40720 alaS; alanine--tRNA ligase AlaS\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"USDA257_c34600 thrS; threonine--tRNA ligase ThrS\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"USDA257_c35710 serS; serine--tRNA ligase SerS\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"USDA257_c08350 cysS; cysteine--tRNA ligase CysS\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"USDA257_c35550 valS; valine--tRNA ligase ValS\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"USDA257_c05010 hisS; histidine--tRNA ligase HisS\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"USDA257_c61340 pheS; phenylalanine--tRNA ligase alpha chain\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"USDA257_c61350 pheT; phenylalanine--tRNA ligase beta chain\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"USDA257_c37960 tyrS; tyrosine--tRNA ligase TyrS\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"USDA257_c00350 trpS; tryptophan--tRNA ligase TrpS\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"USDA257_c37130 alaXM; alanyl-tRNA editing protein AlaX-M\tK07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]"
				}
				]
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"USDA257_c35300 HIT family protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"USDA257_c00410 miaB; (dimethylallyl)adenosine tRNA methylthiotransferase MiaB\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				},
				{
					"name":"USDA257_c57620 putative methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"USDA257_c00500 trmB; tRNA (guanine-N(7)-)-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"USDA257_c00590 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"USDA257_c60810 truB; tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"USDA257_c38000 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex"
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"USDA257_c05820 ywlC; putative tRNA threonylcarbamoyladenosine biosynthesis protein YwlC\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"USDA257_c58560 mnmE; tRNA modification GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"USDA257_c58550 mnmG; tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors",
				"children":[
				{
					"name":"USDA257_c31910 cysQ1; 3'(2'),5'-bisphosphate nucleotidase CysQ\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]"
				},
				{
					"name":"USDA257_c49500 cysQ2; 3'(2'),5'-bisphosphate nucleotidase CysQ\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]"
				}
				]
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"USDA257_c00790 rnpA; ribonuclease P protein componentRnpA\tK03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"USDA257_c00110 rph; ribonuclease PH\tK00989 rph; ribonuclease PH [EC:2.7.7.56]"
				},
				{
					"name":"USDA257_c09110 rnd; ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				},
				{
					"name":"USDA257_c61060 3'-5' exonuclease\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				},
				{
					"name":"USDA257_c08970 putative ribonuclease T2 family protein\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				},
				{
					"name":"USDA257_c45260 putative ribonuclease\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases"
			},
			{
				"name":"tRNA splicing ligases"
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"USDA257_c57430 2'-5' RNA ligase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"USDA257_c45250 putative ABC transporter ATP-binding protein\tK06020 ettA; energy-dependent translational throttle protein EttA"
				}
				]
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"USDA257_c58490 leuS; leucine--tRNA ligase LeuS\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"USDA257_c33170 proS; proline--tRNA ligase ProS\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"USDA257_c37960 tyrS; tyrosine--tRNA ligase TyrS\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"USDA257_c00350 trpS; tryptophan--tRNA ligase TrpS\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"USDA257_c34600 thrS; threonine--tRNA ligase ThrS\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"USDA257_c05130 ileS; isoleucine--tRNA ligase IleS\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"USDA257_c53760 lysS; lysine--tRNA ligase LysS\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"USDA257_c40720 alaS; alanine--tRNA ligase AlaS\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"USDA257_c35550 valS; valine--tRNA ligase ValS\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"USDA257_c40380 metG; methionine--tRNA ligase MetG\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"USDA257_c35710 serS; serine--tRNA ligase SerS\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"USDA257_c09140 aspS; aspartate--tRNA ligase AspS\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"USDA257_c05610 glyQ; glycine--tRNA ligase alpha subunit GlyQ\tK01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]"
				},
				{
					"name":"USDA257_c05650 glyS; glycine--tRNA ligase beta subunit GlyS\tK01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]"
				},
				{
					"name":"USDA257_c08350 cysS; cysteine--tRNA ligase CysS\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"USDA257_c53750 gltX; glutamate--tRNA ligase GltX\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"USDA257_c35620 argS; arginine--tRNA ligase ArgS\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"USDA257_c61340 pheS; phenylalanine--tRNA ligase alpha chain\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"USDA257_c61350 pheT; phenylalanine--tRNA ligase beta chain\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"USDA257_c05010 hisS; histidine--tRNA ligase HisS\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"USDA257_c50460 gluQ; glutamyl-Q tRNA(Asp) synthetase GluQ\tK01894 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"USDA257_c61540 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase YbaK\tK03976 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]"
				},
				{
					"name":"USDA257_c00880 YbaK\/aminoacyl-tRNA synthetase associated region\tK19055 prdX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]"
				},
				{
					"name":"USDA257_c56960 hypothetical protein\tK19055 prdX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]"
				},
				{
					"name":"USDA257_c37130 alaXM; alanyl-tRNA editing protein AlaX-M\tK07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases",
				"children":[
				{
					"name":"USDA257_c41740 dusA; tRNA-dihydrouridine synthase A\tK05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]"
				},
				{
					"name":"USDA257_c34950 dus; putative tRNA-dihydrouridine synthase Dus\tK05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]"
				}
				]
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"USDA257_c00410 miaB; (dimethylallyl)adenosine tRNA methylthiotransferase MiaB\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				},
				{
					"name":"USDA257_c57620 putative methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"USDA257_c51140 3-demethylubiquinone-9 3-O-methyltransferase\tK15257 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"USDA257_c40670 trmJ; tRNA (cytidine\/uridine-2'-O-)-methyltransferase TrmJ\tK02533 lasT; tRNA\/rRNA methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"USDA257_c35830 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO\tK04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]"
				},
				{
					"name":"USDA257_c00500 trmB; tRNA (guanine-N(7)-)-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"USDA257_c57700 trmD; tRNA (guanine-N(1)-)-methyltransferase TrmD\tK00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"USDA257_c58560 mnmE; tRNA modification GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"USDA257_c40990 trmL; tRNA (cytidine(34)-2'-O)-methyltransferase TrmL\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]"
				},
				{
					"name":"USDA257_c00270 ysgA; putative tRNA\/rRNA methyltransferase YsgA\tK03437 spoU; RNA methyltransferase, TrmH family"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"USDA257_c00590 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"USDA257_c60810 truB; tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"USDA257_c40600 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA\tK14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA"
				},
				{
					"name":"USDA257_c50900 hypothetical protein\tK04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]"
				},
				{
					"name":"USDA257_c38060 uncharacterized protein\tK13628 iscA; iron-sulfur cluster assembly protein"
				},
				{
					"name":"USDA257_c38000 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"USDA257_c08260 putative aminomethyltransferase protein\tK06980 ygfZ; tRNA-modifying protein YgfZ"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"USDA257_c58550 mnmG; tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"USDA257_c40160 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase QueA\tK07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]"
				},
				{
					"name":"USDA257_c04420 queC1; 7-cyano-7-deazaguanine synthase QueC\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"USDA257_c13710 queC2; 7-cyano-7-deazaguanine synthase QueC\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"USDA257_c04430 queD; 6-carboxy-5,6,7,8-tetrahydropterin synthase\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"USDA257_c13700 exsC; ExsC protein ExsC\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"USDA257_c04440 hypothetical protein\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"USDA257_c13690 queE; 7-carboxy-7-deazaguanine synthase QueE\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"USDA257_c47140 queF; NADPH-dependent 7-cyano-7-deazaguanine reductase QueF\tK09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]"
				},
				{
					"name":"USDA257_c61720 yjeS; putative electron transport protein YjeS\tK18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]"
				},
				{
					"name":"USDA257_c40170 tgt; queuine tRNA-ribosyltransferase Tgt\tK00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]"
				},
				{
					"name":"USDA257_c51960 tilS; tRNA(Ile)-lysidine synthase TilS\tK04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]"
				},
				{
					"name":"USDA257_c00380 putative peptidase M22, glycoprotease\tK14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB"
				},
				{
					"name":"USDA257_c05820 ywlC; putative tRNA threonylcarbamoyladenosine biosynthesis protein YwlC\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"USDA257_c55930 gcp; putative tRNA threonylcarbamoyladenosine biosynthesis protein Gcp\tK25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"USDA257_c33350 rnr; ribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
			},
			{
				"name":"USDA257_c60840 pnp; polyribonucleotide nucleotidyltransferase Pnp\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
			},
			{
				"name":"USDA257_c28360 ntrR; NtrR2 PIN domain protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
			},
			{
				"name":"USDA257_c29360 vapC; tRNA(fMet)-specific endonuclease VapC\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
			}
			]
		}
		]
	}
	]
}