{
	"name":"sfl03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors"
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex"
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex"
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors"
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex"
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex"
				},
				{
					"name":"Ran-mediated transport factors"
				},
				{
					"name":"eIF4F and regulatory proteins"
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors"
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex"
				},
				{
					"name":"Protein phosphatase 2A"
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins"
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule"
				},
				{
					"name":"P-body specific factors"
				},
				{
					"name":"Stress granule specific factors"
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex"
				},
				{
					"name":"Lsm complex"
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors"
				},
				{
					"name":"Exosome cofactors"
				},
				{
					"name":"TRAMP complex"
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex"
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"SF1088 rne; RNase E\tK08300 rne; ribonuclease E [EC:3.1.26.12]"
					},
					{
						"name":"SF3285 cafA; ribonuclease G\tK08301 rng; ribonuclease G [EC:3.1.26.-]"
					},
					{
						"name":"SF2629 rnc; ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"SF4334 vacB; hypothetical protein\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
					},
					{
						"name":"SF4319 yjeR; hypothetical protein\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"SF3853 rhlB; ATP-dependent RNA helicase RhlB\tK03732 rhlB; ATP-dependent RNA helicase RhlB [EC:5.6.2.7]"
					},
					{
						"name":"SF0747 rhlE; ATP-dependent RNA helicase RhlE\tK11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]"
					},
					{
						"name":"SF3203 deaD; inducible ATP-independent RNA helicase\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
					},
					{
						"name":"SF3900 recQ; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"SF2794 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"SF3205 pnp; polynucleotide phosphorylase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"SF3856 rho; transcription termination factor Rho\tK03628 rho; transcription termination factor Rho"
					},
					{
						"name":"SF3994 pfkA; 6-phosphofructokinase\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"SF0014 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"SF4297 groEL; molecular chaperone GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"SF4327 hfq; RNA-binding protein Hfq\tK03666 hfq; host factor-I protein"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"SF2545 ppk; polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]"
					},
					{
						"name":"SF0135 pcnB; poly(A) polymerase\tK00970 pcnB; poly(A) polymerase [EC:2.7.7.19]"
					},
					{
						"name":"SF2840 ygdP; RNA pyrophosphohydrolase\tK08311 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]"
					},
					{
						"name":"SF2719 csrA; carbon storage regulator\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"SF3290 yhdA; regulatory protein CsrD\tK18765 csrD; RNase E specificity factor CsrD"
					},
					{
						"name":"SF4007 menG; ribonuclease activity regulator protein RraA\tK02553 rraA; regulator of ribonuclease activity A"
					},
					{
						"name":"SF4234 yjgD; RNase E inhibitor protein\tK09893 rraB; regulator of ribonuclease activity B"
					},
					{
						"name":"SF3245 yhbJ; glmZ(sRNA)-inactivating NTPase\tK06958 rapZ; RNase adapter protein RapZ"
					},
					{
						"name":"SF1802 hrpA; ATP-dependent RNA helicase HrpA\tK03578 hrpA; ATP-dependent RNA helicase HrpA [EC:5.6.2.6]"
					},
					{
						"name":"SF0140 hrpB; ATP-dependent RNA helicase HrpB\tK03579 hrpB; ATP-dependent RNA helicase HrpB [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Bacterial Small RNA Regulators",
					"children":[
					{
						"name":"SF4555 dsrA; anti-sense RNA silencer of rcsA gene\tK18502 dsrA; small regulatory RNA DsrA"
					},
					{
						"name":"SF4556 micF; MicF RNA; inhibitor of OpmF\tK18513 micF; small regulatory RNA MicF"
					},
					{
						"name":"SF4558 csrB; CsrB RNA; inhibitor of CsrA\tK18515 csrB; small regulatory RNA CsrB"
					},
					{
						"name":"SF4559 gcvB; gcvB RNA; regulator\tK18521 gcvB; small regulatory RNA GcvB"
					},
					{
						"name":"SF4562 spf; spot 42 RNA\tK18527 spf; small regulatory RNA Spot 42"
					},
					{
						"name":"SF4563 oxyS; OxyS RNA\tK18528 oxyS; small regulatory RNA OxyS"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome"
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}