{
	"name":"sfn02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins"
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"SFy_3950 putative helicase\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"SFy_6263 type III restriction enzyme, res subunit\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"SFy_6260 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"SFy_6261 Type I restriction enzyme EcoEI M protein\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"SFy_4838 Dam methyltransferase with SUUR\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"SFy_4707 methyltransferase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"SFy_2869 Dcm\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok",
				"children":[
				{
					"name":"SFy_5115 HokA\tK18920 hokA; protein HokA"
				},
				{
					"name":"SFy_0020 regulatory protein mokC\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"SFy_0636 hypothetical protein\tK18922 hokE; protein HokE"
				},
				{
					"name":"SFy_0638 hypothetical protein\tK18922 hokE; protein HokE"
				}
				]
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"SFy_0793 hypothetical protein\tK19048 symE; toxic protein SymE"
				},
				{
					"name":"SFy_6259 hypothetical protein\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl",
				"children":[
				{
					"name":"SFy_1762 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"SFy_5084 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"SFy_5086 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"SFy_5088 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"SFy_5091 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				}
				]
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS",
				"children":[
				{
					"name":"SFy_4882 hypothetical protein\tK18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]"
				},
				{
					"name":"SFy_4881 hypothetical protein\tK18842 chpS; antitoxin ChpS"
				}
				]
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"SFy_2223 hypothetical protein\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN",
				"children":[
				{
					"name":"SFy_0379 YafO\tK19160 yafO; mRNA interferase YafO [EC:3.1.-.-]"
				},
				{
					"name":"SFy_0378 YafN\tK19161 yafN; antitoxin YafN"
				}
				]
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"SFy_1881 Phage shock protein C\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"SFy_1880 PsPB\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"SFy_4461 mRNA interferase HigB\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"SFy_4460 DNA-binding helix-turn-helix protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"SFy_0543 YbaQ\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"SFy_2503 YddM\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"SFy_6084 YjgK\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"SFy_1029 YbiM\tK13650 mcbA; MqsR-controlled colanic acid and biofilm protein A"
				},
				{
					"name":"SFy_1537 biofilm formation regulatory protein BssS\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"SFy_1066 biofilm formation regulatory protein BssR\tK19688 bssR; biofilm regulator BssR"
				},
				{
					"name":"SFy_1606 hypothetical protein\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"SFy_0117 Cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"SFy_4694 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"SFy_4373 DNA topoisomerase IV, A subunit\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"SFy_4382 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"SFy_3496 Glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"SFy_1472 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"SFy_4280 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"SFy_1471 putative antitoxin module of toxin-antitoxin system\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				},
				{
					"name":"SFy_4279 putative structural protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"SFy_4104 hypothetical protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"SFy_4105 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein",
				"children":[
				{
					"name":"SFy_2535 hypothetical protein\tK28274 ortT; orphan toxin OrtT"
				}
				]
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"SFy_0512 Modulator of gene expression, with H-NS\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"SFy_0513 YbaJ\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"SFy_3663 YfhO\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}