{
	"name":"sft03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors"
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex"
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex"
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors"
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex"
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex"
				},
				{
					"name":"Ran-mediated transport factors"
				},
				{
					"name":"eIF4F and regulatory proteins"
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors"
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex"
				},
				{
					"name":"Protein phosphatase 2A"
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins"
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule"
				},
				{
					"name":"P-body specific factors"
				},
				{
					"name":"Stress granule specific factors"
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex"
				},
				{
					"name":"Lsm complex"
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors"
				},
				{
					"name":"Exosome cofactors"
				},
				{
					"name":"TRAMP complex"
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex"
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"NCTC1_01141 rne; RNase E,Ribonuclease E,ribonuclease E,Ribonucleases G and E,ribonuclease, Rne\/Rng family,Ribonuclease E\/G family\tK08300 rne; ribonuclease E [EC:3.1.26.12]"
					},
					{
						"name":"NCTC1_03562 cafA; ribonuclease G,Ribonuclease G,ribonuclease G,Ribonucleases G and E,ribonuclease, Rne\/Rng family,Ribonuclease E\/G family\tK08301 rng; ribonuclease G [EC:3.1.26.-]"
					},
					{
						"name":"NCTC1_04709 rnr; exoribonuclease R,Ribonuclease R,exoribonuclease R,Exoribonuclease II,VacB and RNase II family 3'-5' exoribonucleases,RNB domain\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
					},
					{
						"name":"NCTC1_04691 orn; oligoribonuclease,Oligoribonuclease, oligoribonuclease,Exonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"NCTC1_04166 rhlB; ATP-dependent RNA helicase RhlB,ATP-dependent RNA helicase rhlB,ATP-dependent RNA helicase RhlB,Predicted transporter component,ATP-dependent DNA helicase RecQ,DEAD\/DEAH box helicase\tK03732 rhlB; ATP-dependent RNA helicase RhlB [EC:5.6.2.7]"
					},
					{
						"name":"NCTC1_00754 rhlE; ATP-dependent RNA helicase RhlE,ATP-dependent RNA helicase rhlE,ATP-dependent RNA helicase RhlE,Predicted transporter component,ATP-dependent DNA helicase RecQ,DEAD\/DEAH box helicase\tK11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]"
					},
					{
						"name":"NCTC1_03474 deaD; ATP-dependent RNA helicase DeaD,Cold-shock DEAD box protein A,ATP-dependent RNA helicase DeaD,Predicted transporter component,ATP-dependent DNA helicase RecQ,DEAD\/DEAH box helicase\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
					},
					{
						"name":"NCTC1_04217 recQ; ATP-dependent DNA helicase RecQ,ATP-dependent DNA helicase recQ,ATP-dependent DNA helicase RecQ,Lhr-like helicases,ATP-dependent DNA helicase RecQ,RQC domain\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"NCTC1_03073 eno; phosphopyruvate hydratase,Enolase,enolase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,phosphopyruvate hydratase,Enolase, C-terminal TIM barrel domain\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"NCTC1_03476 pnp; polynucleotide phosphorylase\/polyadenylase,Polyribonucleotide nucleotidyltransferase,polynucleotide phosphorylase\/polyadenylase,Lipoprotein NlpI, contains TPR repeats,polyribonucleotide nucleotidyltransferase,3' exoribonuclease family, domain 1\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"NCTC1_04168 rho; Transcription termination factor rho,Transcription termination factor Rho,transcription termination factor Rho,transcription termination factor Rho,ATP synthase alpha\/beta family, nucleotide-binding domain\tK03628 rho; transcription termination factor Rho"
					},
					{
						"name":"NCTC1_04324 pfkA; 6-phosphofructokinase,6-phosphofructokinase isozyme 1,6-phosphofructokinase,P pilus assembly\/Cpx signaling pathway, periplasmic inhibitor\/zinc-resistance associated protein,6-phosphofructokinase,Phosphofructokinase\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"NCTC1_00014 dnaK_1; molecular chaperone DnaK,Heat shock protein 70,molecular chaperone DnaK,Ethanolamine utilization protein, possible chaperonin,chaperone protein DnaK,Hsp70 protein\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"NCTC1_04666 groEL; chaperonin GroEL,hypothetical protein,chaperonin GroEL,chaperonin GroL,TCP-1\/cpn60 chaperonin family\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"NCTC1_04702 hfq; RNA-binding protein Hfq,Host factor-I protein,RNA-binding protein Hfq,RNA chaperone Hfq,LSM domain\tK03666 hfq; host factor-I protein"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"NCTC1_02798 ppk; polyphosphate kinase,Polyphosphate kinase,polyphosphate kinase,polyphosphate kinase 1,Polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]"
					},
					{
						"name":"NCTC1_00138 pcnB; poly(A) polymerase I,Poly(A) polymerase precursor,poly(A) polymerase I,poly(A) polymerase,Polymerase A arginine-rich C-terminus\tK00970 pcnB; poly(A) polymerase [EC:2.7.7.19]"
					},
					{
						"name":"NCTC1_03125 nudH; dinucleoside polyphosphate hydrolase,RNA pyrophosphohydrolase,RNA pyrophosphohydrolase,Predicted NTP pyrophosphohydrolase,mutator mutT protein,NUDIX domain\tK08311 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]"
					},
					{
						"name":"NCTC1_02994 csrA; carbon storage regulator,Carbon storage regulator,carbon storage regulator,carbon storage regulator,Global regulator protein family\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"NCTC1_03567 csrD; regulatory protein CsrD,Regulator of CsrB and CsrC decay CsrD,regulatory protein CsrD,MHYT domain (predicted integral membrane sensor domain),diguanylate cyclase (GGDEF) domain,EAL domain\tK18765 csrD; RNase E specificity factor CsrD"
					},
					{
						"name":"NCTC1_04337 rraA; ribonuclease activity regulator protein RraA,Regulator of ribonuclease activity A,ribonuclease activity regulator protein RraA,ATP-dependent protease HslVU (ClpYQ), peptidase subunit,regulator of ribonuclease activity A,Demethylmenaquinone methyltransferase\tK02553 rraA; regulator of ribonuclease activity A"
					},
					{
						"name":"NCTC1_04602 yjgD; RNase E inhibitor protein,Regulator of ribonuclease activity B,RNase E inhibitor protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1260)\tK09893 rraB; regulator of ribonuclease activity B"
					},
					{
						"name":"NCTC1_03521 yhbJ; glmZ(sRNA)-inactivating NTPase,hypothetical protein,glmZ(sRNA)-inactivating NTPase,Predicted P-loop-containing kinase,P-loop ATPase protein family\tK06958 rapZ; RNase adapter protein RapZ"
					},
					{
						"name":"NCTC1_01939 hrpA; ATP-dependent RNA helicase HrpA,ATP-dependent RNA helicase HrpA,ATP-dependent helicase HrpA,Domain of unknown function (DUF3418)\tK03578 hrpA; ATP-dependent RNA helicase HrpA [EC:5.6.2.6]"
					},
					{
						"name":"NCTC1_00143 hrpB; ATP-dependent RNA helicase HrpB,ATP-dependent RNA helicase HrpB,Superfamily II DNA\/RNA helicase required for DNA uptake (late competence protein),ATP-dependent helicase HrpB,ATP-dependent helicase C-terminal\tK03579 hrpB; ATP-dependent RNA helicase HrpB [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome"
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}